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https://www.readbyqxmd.com/read/27926974/pregnant-patient-knowledge-and-behavior-regarding-perinatal-oral-health
#1
Bernard Gonik, Eline Wilson, Melanie Mayberry, Bushra Yuki Joarder
Objective Perinatal oral health is important to obstetric practice, with significant implications for maternal, fetal, and infant health. This study sought to describe and compare knowledge and behavior related to perinatal oral health in two distinct populations of pregnant women. Methods An anonymous 13-question survey was distributed at two patient centers (urban teaching clinics and suburban referral center), examining patient knowledge and behaviors pertaining to oral health. Descriptive statistics were tabulated...
December 7, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27926855/temporally-programmed-cd8%C3%AE-dc-activation-enhances-combination-cancer-immunotherapy
#2
Alice Tzeng, Monique J Kauke, Eric F Zhu, Kelly D Moynihan, Cary F Opel, Nicole J Yang, Naveen Mehta, Ryan L Kelly, Gregory L Szeto, Willem W Overwijk, Darrell J Irvine, K Dane Wittrup
Numerous synergistic cancer immunotherapy combinations have been identified, but the effects of relative dose timing are rarely considered. In established syngeneic mouse tumor models, we found that staggering interferon-α (IFNα) administration after, rather than before or simultaneously with, serum-persistent interleukin-2 (IL-2) and tumor-specific antibody significantly increased long-term survival. Successful combination therapy required IFNα-induced activation of cross-presenting CD8α(+) dendritic cells (DCs) following the release of antigenic tumor debris by the IL-2- and antibody-mediated immune response...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27926536/a-minimal-titration-model-of-the-mammalian-dynamical-heat-shock-response
#3
Aude Sivéry, Emmanuel Courtade, Quentin Thommen
Environmental stress, such as oxidative or heat stress, induces the activation of the heat shock response (HSR) and leads to an increase in the heat shock proteins (HSPs) level. These HSPs act as molecular chaperones to maintain cellular proteostasis. Controlled by highly intricate regulatory mechanisms, having stress-induced activation and feedback regulations with multiple partners, the HSR is still incompletely understood. In this context, we propose a minimal molecular model for the gene regulatory network of the HSR that reproduces quantitatively different heat shock experiments both on heat shock factor 1 (HSF1) and HSPs activities...
December 7, 2016: Physical Biology
https://www.readbyqxmd.com/read/27926492/the-cross-talk-between-autophagy-and-endocytoplasmic-reticulum-stress-in-blood-spinal-cord-barrier-disruption-after-spinal-cord-injury
#4
Yulong Zhou, Yanqing Wu, Yanlong Liu, Zili He, Shuang Zou, Qingqing Wang, Jiawei Li, Zengming Zheng, Jian Chen, Fenzan Wu, Fanhua Gong, Hongyu Zhang, Huazi Xu, Jian Xiao
Spinal cord injury induces the disruption of blood-spinal cord barrier and triggers a complex array of tissue responses, including endocytoplasmic reticulum (ER) stress and autophagy. However, the roles of ER stress and autophagy in blood-spinal cord barrier disruption have not been discussed in acute spinal cord trauma. In the present study, we respectively detected the roles of ER stress and autophagy in blood-spinal cord barrier disruption after spinal cord injury. Besides, we also detected the cross-talking between autophagy and ER stress both in vivo and in vitro...
December 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925695/integrated-biomarker-profiling-of-smokers-with-periodontitis
#5
Radhakrishnan Nagarajan, Mohanad Al-Sabbagh, Dolph Dawson, Jeffrey Ebersole
: In the context of precision medicine, understanding patient-specific variation is an important step in developing targeted and patient-tailored treatment regimens for periodontitis. While several studies have successfully demonstrated the usefulness of molecular expression profiling in conjunction with single classifier systems in discerning distinct disease groups, the majority of these studies do not provide sufficient insights into potential variations within the disease groups. AIM: The goal of the present study is to discern biological response profiles of periodontitis and non-periodontitis smoking subjects using an informed panel of biomarkers across multiple scales (salivary, oral microbiome, pathogens and other markers)...
December 7, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27925451/improving-access-and-systems-of-care-for-evidence-based-childhood-obesity-treatment-conference-key-findings-and-next-steps
#6
REVIEW
Denise E Wilfley, Amanda E Staiano, Myra Altman, Jeanne Lindros, Angela Lima, Sandra G Hassink, William H Dietz, Stephen Cook
OBJECTIVE: To improve systems of care to advance implementation of the U.S. Preventive Services Task Force recommendations for childhood obesity treatment (i.e., clinicians offer/refer children with obesity to intensive, multicomponent behavioral interventions of >25 h over 6 to 12 months to improve weight status) and to expand payment for these services. METHODS: In July 2015, 43 cross-sector stakeholders attended a conference supported by the Agency for Healthcare Research and Quality, American Academy of Pediatrics Institute for Healthy Childhood Weight, and The Obesity Society...
December 7, 2016: Obesity
https://www.readbyqxmd.com/read/27925430/pulmonary-hypertension-as-estimated-by-doppler-echocardiography-in-adolescent-and-adult-patients-with-cystic-fibrosis-and-their-relationship-with-clinical-lung-function-and-sleep-findings
#7
Bruna Ziegler, Christiano Perin, Fernanda Cano Casarotto, Simone Chaves Fagondes, Sérgio Saldanha Menna-Barreto, Paulo de Tarso Roth Dalcin
BACKGROUND: In cystic fibrosis (CF) patients, end stage of pulmonary disease is characterized by pulmonary hypertension (PH), hypoxemia, decrease in exercise tolerance and sleep quality. OBJECTIVE: To evaluate the association between clinical, lung function, sleep quality and polysomnographic variables with PH in CF patients aged 16 years or older. METHODS: In a cross-sectional study, 51 clinically stable CF patients underwent a clinical evaluation, an overnight polysomnography and answered sleep questionnaires (Pittsburgh Sleep Quality Index - PSQI and Epworth sleepiness scale - ESS)...
December 7, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27925350/a-kidney-transplant-recipient-with-renal-medullary-viral-cytopathic-changes
#8
Poornima Ramanan, Elizabeth A Timmerman, Mary E Fidler, Hatem Amer, Bobbi S Pritt, Dale A Schwab, Hollis J Batterman, Matthew J Binnicker
We present a case of JC polyomavirus (JCV)-associated nephropathy (PyVAN) in an asymptomatic deceased-donor kidney transplant recipient. Despite the presence of viral cytopathic effect in the kidney biopsy and positive BK polyomavirus (BKV) in situ hybridization (ISH), BKV real-time polymerase chain reaction (PCR) results of plasma and urine were negative. JCV ISH was performed and was found to be positive. JCV real-time PCR on urine, plasma, and the kidney biopsy tissue was positive. Reduction in immunosuppression resulted in resolution of JCV viremia...
December 7, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27925096/socio-environmental-approach-in-nursing-focusing-on-rural-labor-and-the-use-of-pesticides
#9
Marta Regina Cezar-Vaz, Clarice Alves Bonow, Marlise Capa Verde Almeida de Mello, Mara Regina Santos da Silva
Objective: to apply a socio-environmental approach to the relationship between human health and rural labor through a link verification/association between health disorders and the use of pesticides. Method: this is a quantitative, cross-sectional, observational and exploratory study with 331 inhabitants of two cities in the state of Rio Grande do Sul, Brazil. Data analysis was conducted by Poisson regression. Results: reported health disorders included: mental (62...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27925045/interest-in-research-among-medical-students-challenges-for-the-undergraduate-education
#10
David William Moraes, Maitê Jotz, Willian Roberto Menegazzo, Michele Sabrina Menegazzo, Steffi Veloso, Mayara Christ Machry, Monise Costanzi, Lucia Campos Pellanda
Introduction: In recent decades, there has been a reduction in the number of graduates from medical schools who choose to pursue a career in scientific research. That has an impact on the profile of graduates, since medical education depends on understanding the formation of scientific evidence. The construction of new knowledge is also hampered by the reduction of medical scientists, whose clinical experience with patients provides an essential step towards medical Science evolution...
October 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27925020/susceptibility-of-phytomonas-serpens-to-calpain-inhibitors-in-vitro-interference-on-the-proliferation-ultrastructure-cysteine-peptidase-expression-and-interaction-with-the-invertebrate-host
#11
Simone Santiago Carvalho de Oliveira, Diego de Souza Gonçalves, Aline Dos Santos Garcia-Gomes, Inês Correa Gonçalves, Sergio Henrique Seabra, Rubem Figueiredo Menna-Barreto, Angela Hampshire de Carvalho Santos Lopes, Claudia Masini D'Avila-Levy, André Luis Souza Dos Santos, Marta Helena Branquinha
A pleiotropic response to the calpain inhibitor MDL28170 was detected in the tomato parasite Phytomonas serpens. Ultrastructural studies revealed that MDL28170 caused mitochondrial swelling, shortening of flagellum and disruption of trans Golgi network. This effect was correlated to the inhibition in processing of cruzipain-like molecules, which presented an increase in expression paralleled by decreased proteolytic activity. Concomitantly, a calcium-dependent cysteine peptidase was detected in the parasite extract, the activity of which was repressed by pre-incubation of parasites with MDL28170...
December 1, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27925016/association-between-neurological-injury-and-the-severity-of-oropharyngeal-dysphagia-after-stroke
#12
Danielle Martins Otto, Marlise de Castro Ribeiro, Liselotte Menke Barea, Renata Mancopes, Sheila Tamanini de Almeida
Purpose: To associate the degree of biomechanical impairment in the swallowing process with the severity (National Institute of Health Stroke Scale - NIHSS) and type of neurological injury in patients post stroke. Methods: A cross-sectional, descriptive study conducted with 42 patients (22 females), aged 65.7 years on average diagnosed with stroke. All patients underwent clinical neurological evaluation and application of the NIHSS in the first 48 hours after stroke...
December 1, 2016: CoDAS
https://www.readbyqxmd.com/read/27924688/susceptibility-to-vaccine-preventable-diseases-and-vaccination-adherence-among-healthcare-workers-in-italy-a-cross-sectional-survey-at-a-regional-acute-care-university-hospital-and-a-systematic-review
#13
Umberto Leone Roberti Maggiore, Carolina Scala, Alessandra Toletone, Nicoletta Debarbieri, Mauro Perria, Beatrice D'Amico, Alfredo Montecucco, Mariano Martini, Guglielmo Dini, Paolo Durando
Healthcare Workers (HCWs) have an increased risk both to acquire and to spread vaccine preventable diseases (VPDs) both to their colleagues and, especially, to vulnerable patients. The prevention of occupational hazards among HCWs is based on proper adoption of the standard and additional precautions, immunizations, and secondary preventive measures, such as post-exposure prophylaxis. Moreover, HCWs are often referred to as the most trusted source of vaccine-related information for their patients. In the present article, we report the findings of a cross-sectional study investigating the compliance to vaccinations among HCWs employed at the Obstetric Unit of a regional acute-care University Hospital in Northern Italy...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27924408/tackling-longitudinal-round-robin-data-a-social-relations-growth-model
#14
Steffen Nestler, Katharina Geukes, Roos Hutteman, Mitja D Back
The social relations model (SRM) is commonly used in the analysis of interpersonal judgments and behaviors that arise in groups. The SRM was developed only for use with cross-sectional data. Here, we introduce an extension of the SRM to longitudinal data. The social relations growth model represents a person's repeated SRM judgments of another person as a function of time. We show how the model's parameters can be estimated using restricted maximum likelihood, and how the effects of covariates on interindividual and interdyad variability in growth can be computed...
December 6, 2016: Psychometrika
https://www.readbyqxmd.com/read/27924347/preprocessing-structured-clinical-data-for-predictive-modeling-and-decision-support-a-roadmap-to-tackle-the-challenges
#15
José Carlos Ferrão, Mónica Duarte Oliveira, Filipe Janela, Henrique M G Martins
BACKGROUND: EHR systems have high potential to improve healthcare delivery and management. Although structured EHR data generates information in machine-readable formats, their use for decision support still poses technical challenges for researchers due to the need to preprocess and convert data into a matrix format. During our research, we observed that clinical informatics literature does not provide guidance for researchers on how to build this matrix while avoiding potential pitfalls...
December 7, 2016: Applied Clinical Informatics
https://www.readbyqxmd.com/read/27924296/data-in-support-of-covalent-attachment-of-tyrosinase-onto-cyanuric-chloride-crosslinked-magnetic-nanoparticles
#16
Kourosh Abdollahi, Farshad Yazdani, Reza Panahi
Preparation and characterization of cross linked amine-functionalized magnetic nanoparticles as an appropriate support for covalent immobilization on tyrosinase was presented in the study "Covalent immobilization of tyrosinase onto cyanuric chloride crosslinked amine-functionalized superparamagnetic nanoparticles: synthesis and characterization of the recyclable nanobiocatalyst" (Abdollahi et al., 2016 ) [1]. Herein, complementary data regarding X-ray powder diffraction (XRD) to characterize the synthesized magnetic nanoparticles, and transmission electron microscopy (TEM) to determine the size and morphology of tyrosinase immobilized magnetic nanoparticles (tyrosinase-MNPs) were reported...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27924281/causality-analysis-detects-the-regulatory-role-of-maternal-effect-genes-in-the-early-drosophila-embryo
#17
Zara Ghodsi, Xu Huang, Hossein Hassani
In developmental studies, inferring regulatory interactions of segmentation genetic network play a vital role in unveiling the mechanism of pattern formation. As such, there exists an opportune demand for theoretical developments and new mathematical models which can result in a more accurate illustration of this genetic network. Accordingly, this paper seeks to extract the meaningful regulatory role of the maternal effect genes using a variety of causality detection techniques and to explore whether these methods can suggest a new analytical view to the gene regulatory networks...
March 2017: Genomics Data
https://www.readbyqxmd.com/read/27924277/model-simulation-of-the-spoc-wave-in-a-bundle-of-striated-myofibrils
#18
Koutaro Nakagome, Katsuhiko Sato, Seine A Shintani, Shin'ichi Ishiwata
SPOC (spontaneous oscillatory contraction) is a phenomenon observed in striated muscle under intermediate activation conditions. Recently, we constructed a theoretical model of SPOC for a sarcomere, a unit sarcomere model, which explains the behavior of SPOC at each sarcomere level. We also constructed a single myofibril model, which visco-elastically connects the unit model in series, and explains the behaviors of SPOC at the myofibril level. In the present study, to understand the SPOC properties in a bundle of myofibrils, we extended the single myofibril model to a two-dimensional (2D) model and a three-dimensional (3D) model, in which myofibrils were elastically connected side-by-side through cross-linkers between the Z-lines and M-lines...
2016: Biophysics and Physicobiology
https://www.readbyqxmd.com/read/27923972/lifestyle-behaviors-subjective-health-and-quality-of-life-among-chinese-men-living-with-type-2-diabetes
#19
Ghose Bishwajit, Shangfeng Tang, Sanni Yaya, Zhifei He, Zhanchun Feng
The aim of the present study was to investigate the association between self-reported health (SRH) and quality of life (QoL) with five lifestyle-related behaviors including tobacco smoking, drinking alcohol, physical activity status, consumption of fruits, and consumption of vegetables among men diagnosed with type 2 diabetes. Participants were 786 Chinese men older than 40 years and living in urban households. Cross-sectional data on self-rated health, associated sociodemographics, and health-related behaviors were collected from the Study on Global AGEing and Health (Wave 1) of World Health Organization...
December 5, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27923810/durability-of-three-different-types-of-hyaluronic-acid-fillers-in-skin-are-there-differences-among-biphasic-monophasic-monodensified-and-monophasic-polydensified-products
#20
Adilson da Costa, Danilo Guerreiro Zeolo Biccigo, Ellem Tatiani de Souza Weimann, Larissa Mondadori Mercadante, Paulo Roberto Grimaldi Oliveira, Stefânia Bazanelli Prebianchi, Beatrice Martinez Zugaib Abdalla
BACKGROUND: Hyaluronic acid fillers are used for facial rejuvenation and are classified as non-cross-linked or cross-linked (monophasic mono- or polydensified). OBJECTIVES: To histologically assess the intradermal durability of three types of fillers (biphasic, monophasic monodensified, and monophasic polydensified), to compare the durability of the products over 6 months, and to evaluate the structural changes after application. METHODS: In all, 25 volunteers received injections of three different fillers in the dermis of the right lumbar region (in one line), and equal amounts of the fillers were injected into three different sites (in the same column), yielding nine points of application in each patient...
December 6, 2016: Aesthetic Surgery Journal
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