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Zarqa Ali, Charlotte Suppli Ulrik, Tove Agner, Simon Francis Thomsen
Obesity has been associated with atopic dermatitis (AD), however the results have been conflicting. Our aim was to provide an update on current knowledge from observational studies addressing the possible association between obesity and AD. Systematic literature review was performed by identifying studies addressing a possible link between AD and overweight/obesity from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)-guidelines...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Elvin J Lauron, Liping Yang, Jabari I Elliott, Maria D Gainey, Daved H Fremont, Wayne M Yokoyama
Viruses have evolved mechanisms of MHCI inhibition in order to evade recognition by cytotoxic CD8+ T cells (CTLs), which is well-illustrated by our prior studies on cowpox virus (CPXV) that encodes potent MHCI inhibitors. Deletion of CPXV viral MHCI inhibitors markedly attenuated in vivo infection due to effects on CTL effector function, not priming. However, the CTL response to CPXV in C57BL/6 mice is dominated by a single peptide antigen presented by H-2Kb. Here we evaluated the effect of viral MHCI inhibition on immunodominant (IDE) and subdominant epitopes (SDE) as this has not been thoroughly examined...
February 2018: PLoS Pathogens
Raji Ramachandran Pillai, Anand Babu Wilson, Nancy R Premkumar, Shivanand Kattimani, Haritha Sagili, Soundravally Rajendiran
Postpartum depression (PPD) is a psychiatric complication of childbirth affecting 10-20% of new mothers and has negative impact on both mother and infant. Serum lipid levels have been related to depressive disorders, but very limited literatures are available regarding the lipid levels in women with postpartum depression. The present study is aimed to examine the association of serum lipids with the development of postpartum depressive symptoms. This is a cross sectional study conducted at a tertiary care hospital in South India...
2018: PloS One
Jennifer Erskine, Duncan England, Connor Kupchak, Benjamin Sussman
Photon pair sources have wide ranging applications in a variety of quantum photonic experiments and protocols. Many of these protocols require well controlled spectral correlations between the two output photons. However, due to low cross-sections, measuring the joint spectral properties of photon pair sources has historically been a challenging and time-consuming task. Here, we present an approach for the real-time measurement of the joint spectral properties of a fiber-based four wave mixing source. We seed the four wave mixing process using a broadband chirped pulse, studying the stimulated process to extract information regarding the spontaneous process...
February 15, 2018: Optics Letters
Hao Yu, Zheng Qian, Huayi Liu, Jiaqi Qu
This paper analyzes the measurement error, caused by the position of the current-carrying conductor, of a circular array of magnetic sensors for current measurement. The circular array of magnetic sensors is an effective approach for AC or DC non-contact measurement, as it is low-cost, light-weight, has a large linear range, wide bandwidth, and low noise. Especially, it has been claimed that such structure has excellent reduction ability for errors caused by the position of the current-carrying conductor, crosstalk current interference, shape of the conduction cross-section, and the Earth's magnetic field...
February 14, 2018: Sensors
Tanya L Zakrison, Rishi Rattan, Davel Milian Valdés, Xiomara Ruiz, Rondi Gelbard, John Cline, David Turay, Xian Luo-Owen, Nicholas Namias, Jessica George, Dante Yeh, Daniel Pust, Brian H Williams
INTRODUCTION: A recent EAST-supported, multicenter trial demonstrated a similar rate of intimate partner and sexual violence (IPSV) between male and female trauma patients, regardless of mechanism. Our objective was to perform a subgroup analysis of our affected male cohort as this remains an understudied group in the trauma literature. METHODS: We conducted a recent EAST-supported, cross-sectional, multicenter trial over one year (03/15-04/16) involving four Level I trauma centers throughout the United States...
February 14, 2018: Journal of Trauma and Acute Care Surgery
Eric J Cotter, Charles P Hannon, David Christian, Rachel M Frank, Bernard R Bach
CONTEXT: Shoulder pain and dysfunction are common, with patients presenting complaints to both primary and orthopaedic physicians. History and physical examination remain essential to creating a differential diagnosis, even as noninvasive imaging has improved. EVIDENCE ACQUISITION: Literature was obtained through keyword searches based on the pathology in question (eg, rotator cuff) and the keywords physical examination using PubMed from January 1, 1980, through September 20, 2017...
February 1, 2018: Sports Health
Nidhi Sinha, Paresh Modak, Suvam Singh, Bobby Antony
The well-known spherical complex optical potential (SCOP) and complex scattering potential-ionisation contribution (CSP-ic) methods with appropriate modifications are applied to the $CH_3X$ (X=F, Cl, Br and I) molecules to compute positron scattering cross sections, which rather is the first theoretical attempt to report the same. Besides, various inelastic cross sections are also predicted for the first time in this article. We have utilized the multi-scattering spherical complex optical potential (MSCOP) approach to derive these cross sections...
February 14, 2018: Journal of Physical Chemistry. A
W Stovall, H R Taylor, M Black, S Grosser, K Rutherford, N J Gemmell
Establishing the sex of individuals in wild systems can be challenging and often requires genetic testing. Genotyping-by-sequencing (GBS) and other reduced-representation DNA sequencing (RRS) protocols (e.g., RADseq, ddRAD) have enabled the analysis of genetic data on an unprecedented scale. Here, we present a novel approach for the discovery and statistical validation of sex-specific loci in GBS datasets. We used GBS to genotype 166 New Zealand fur seals (NZFS, Arctocephalus forsteri) of known sex. We retained monomorphic loci as potential sex-specific markers in the locus discovery phase...
February 14, 2018: Molecular Ecology Resources
Roy Beigel, Israel Mazin, Edward Koifman, Michael Shechter, Hanna Pres, Nir Shlomo, Nurit Rosenberg, Elad Asher, Shlomi Matetzky
BACKGROUND: Recent studies have shown that the thromboxaneA 2 -dependent pathway is dependent upon the adenosine diphosphate (ADP)-P2Y 12 pathway and that strong P2Y 12 receptor blockade alone causes inhibition of platelet aggregation that is minimally enhanced by aspirin. Data from the PLATO trial suggested that among ticagrelor-treated patients, high compared with low dose (<100mg\day) aspirin is associated with increased risk for ischemic events. OBJECTIVES: In the current prospective, randomized, placebo-controlled, double-blind, cross-over study, we sought to evaluate the impact of aspirin withdrawal on platelet reactivity in acute coronary syndrome (ACS) patients treated with a potent P2Y 12 blocker...
February 14, 2018: Journal of Thrombosis and Haemostasis: JTH
Paul Tan, Émilie Pepin, Julie L Lavoie
Compared to other tissues, white adipose tissue has a considerably less RNA and protein content for downstream applications such as real-time PCR and Western Blot, since it mostly contains lipids. RNA isolation from adipose tissue samples is also challenging as extra steps are required to avoid these lipids. Here, we present a procedure to collect three anatomically different white adipose tissues from mice, to process these samples and perform RNA isolation. We further describe the synthesis of cDNA and gene expression experiments using real-time PCR...
January 31, 2018: Journal of Visualized Experiments: JoVE
Marianna Triantou, Nadia Todorova, Tatiana Giannakopoulou, Tiverios Vaimakis, Christos Trapalis
In the present research, graphene nanoplatelets/polypropylene (GNP/PP) nanocomposites were prepared by melt mixing and were subjected to accelerated ageing. The effect of graphene on the morphology and physical properties of aged GNP/PP nanocomposites was investigated. The incorporation of graphene to non-aged PP matrix led to changes in its crystal conformation, decreased the ultraviolet-visible (UV-Vis) transmittance and tensile strain and increased the elastic modulus. The ageing of non-reinforced PP increased the β-phase of PP and caused the formation of cracks on its surface, while voids were observed in its cross-section...
July 1, 2018: Journal of Nanoscience and Nanotechnology
Yoshifumi Fukunishi, Yasunobu Yamashita, Tadaaki Mashimo, Haruki Nakamura
We used protein-compound docking simulations to develop a structure-based quantitative structure-activity relationship (QSAR) model. The prediction model used docking scores as descriptors. The binding free energy was approximated by a weighted average of docking scores for multiple proteins. This approximation was based on a pharmacophore model of receptor pockets and compounds. The weights of the docking scores were restricted to small values to avoid unrealistic weights by a regularization term. Additional outlier elimination improved the results...
February 14, 2018: Molecular Informatics
Oliver Reuthebuch, Luca Koechlin, Ulrich Schurr, Martin Grapow, Jens Fassl, Friedrich S Eckstein
OBJECTIVE: To assess the clinical implementation and report preliminary results of a novel technique called the Ozaki procedure for stentless aortic valve replacement through reconstruction of the valve leaflets from autologous pericardium. METHOD: Between September 2015 and May 2017 30 patients (20 males, mean ± standard deviation age 66.83 ± 10.55 years) suffering from aortic stenosis (AS, n = 7), aortic regurgitation (AR, n = 12), or a combination of both (AS/AR, n = 11) were assigned for an Ozaki procedure...
February 14, 2018: Swiss Medical Weekly
Roshan Shetty, Vijaya Hegde, Pooja J Shetty
Background and Objectives: Dental caries and malocclusion are common dental public health problems. Surveys provide us with an insight into the oral health status and treatment needs and also help in proper treatment planning. Hence, the objective of this study was to assess the malocclusion status, dentition status, and treatment needs of 15-year-old school children of Mangalore. Methodology: A cross-sectional study of 1001 school children aged 15-year-old was conducted in Mangalore...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
B Tubić, B Marković, S Vladimirov, S Savić, J Poljarević, T Sabo
Fourteen compounds representing ester derivatives of (S,S)-1,2-ethanediamine-N,N'-di-2-(3-cyclohexyl) propanoic and (S,S)-1,3-propanediamine-N,N'-di-2-(3-cyclohexyl)propanoic acids, expressing antiproliferative activity in vitro were examined. The objective of this study was to determinate their lipophilicity data, and also to ensure a mathematical model for prediction lipophilicity data of potential in vivo metabolites and new derivatives of (S,S)-1,2-ethanediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid, based on chromatographic parameters...
June 1, 2017: Die Pharmazie
Ahmet Talha Uzumcu, Orhan Guney, Oguz Okay
We present mechanically strong and self-healable clay hydrogels containing 2 to 8 w/v% ds-DNA together with a synthetic biocompatible polymer, poly(N,N-dimethylacrylamide). Clay nanoparticles in the hydrogels act like a chemical cross-linker and promote their elastic behavior while DNA contributes to their viscoelastic energy dissipation. The extent of mechanical hysteresis during cyclic tensile tests reveals that the strength of intermolecular bonds in DNA/clay hydrogels is in the range of the strength of hydrogen bonds...
February 14, 2018: ACS Applied Materials & Interfaces
Mina S Makary, Edward L Gayou, Douglas Kyrouac, Zarine K Shah
A pancreatic-portal vein fistula (PPVF) is an extremely rare complication of pancreatitis. In this report, we present a patient with a PPVF in the setting of recurrent pancreatitis and portal vein thrombosis diagnosed by cross-sectional imaging and endoscopic retrograde cholangio-pancreatography, who responded to medical management and anticoagulation. A critical review of this disease process is explored to highlight pathology, imaging characteristics, and essential alternative diagnostic considerations. We also discuss potential complications and current treatment strategies...
2018: Journal of Clinical Imaging Science
Liv Wergeland Sørbye, Sidsel Sverdrup, Birgit Brunborg Pay
Aim: Home-based nursing care is relatively easy to access in Norway compared to the rest of Europe, and the threshold for applying for assistance is relatively low. The aim of the present study was to analyze factors that enable frail older adults to live in their own homes, with a low level of care burden stress. Methodology: In 2015 and 2016, eight municipalities from different parts of Norway participated in a cross-sectional study. The quantitative part of the project consisted of assessing care of 71 older adults, aged ≥80 years, using a geriatric comprehensive assessment...
2018: Journal of Multidisciplinary Healthcare
Mugove Gerald Madziyire, Chelsea B Polis, Taylor Riley, Elizabeth A Sully, Onikepe Owolabi, Tsungai Chipato
OBJECTIVES: Abortion complications cause significant morbidity and mortality. We aimed to assess the severity and factors associated with abortion complications (induced or spontaneous), and the management of postabortion care (PAC) in Zimbabwe. DESIGN: Prospective, facility-based 28 day survey among women seeking PAC and their providers. SETTING: 127 facilities in Zimbabwe with the capacity to provide PAC, including all central and provincial hospitals, and a sample of primary health centres (30%), district/general/mission hospitals (52%), private (77%) and non-governmental organisation (NGO) (68%) facilities...
February 10, 2018: BMJ Open
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