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https://www.readbyqxmd.com/read/29050381/space-based-bias-of-covert-visual-attention-in-complex-regional-pain-syndrome
#1
Janet H Bultitude, Ian Walker, Charles Spence
See Legrain (doi:10.1093/awx188) for a scientific commentary on this article. Some patients with complex regional pain syndrome report that movements of the affected limb are slow, more effortful, and lack automaticity. These symptoms have been likened to the syndrome that sometimes follows brain injury called hemispatial neglect, in which patients exhibit attentional impairments and problems with movements affecting the contralesional side of the body and space. Psychophysical testing of patients with complex regional pain syndrome has found evidence for spatial biases when judging visual targets distanced at 2 m, but not in directions that indicate reduced attention to the affected side...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29050321/interaction-among-cyp2c8-gpiiia-and-p2y12-variants-increase-susceptibility-to-ischemic-stroke-in-chinese-population
#2
Xingyang Yi, Jing Lin, Yanfen Wang, Ju Zhou, Qiang Zhou
PURPOSE: Genetic variants in cytochrome P450 (CYP), platelet membrane receptor (P2Y12, P2Y1), and glycoprotein IIIa (GPIIIa) genes are associated with the efficacy of clopidogrel and adverse clinical events on ischemic stroke (IS) patients. However, few studies have assessed whether gene-gene interactions among these genes influence the risk of IS. The aim of the present study was to investigate the association of fifteen variants with IS and to determine whether these gene-gene interactions increase the risk of IS...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050316/pharmacokinetics-and-drug-drug-interaction-between-enalapril-enalaprilat-and-felodipine-extended-release-er-in-healthy-subjects
#3
Dai Li, Sumei Xu, Yulu Wang, Dan Li, Xiaomin Li, Jing Pan, Pingsheng Xu
Since angiotensin-converting enzyme (ACE) inhibitors and calcium antagonists have complimentary mechanisms of action, enalapril, an ACE inhibitor, is used in combination with felodipine, a vascular selective dihydropyridine calcium antagonist, for the treatment of hypertension. The present study was designed to investigate the possible drug-drug interaction between these two agents in Chinese healthy subjects. A randomized, open-label, multiple-dose, 3-treatment, 3-period, 6-sequence cross-over study enrolling 12 healthy subjects (six male and six female subjects) was performed...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050232/progressive-modulation-of-the-human-olfactory-bulb-transcriptome-during-alzheimer%C3%A2-s-disease-evolution-novel-insights-into-the-olfactory-signaling-across-proteinopathies
#4
Mercedes Lachen-Montes, María Victoria Zelaya, Víctor Segura, Joaquín Fernández-Irigoyen, Enrique Santamaría
Alzheimer´s disease (AD) is characterized by progressive dementia, initially presenting olfactory dysfunction. Despite the olfactory bulb (OB) is the first central structure of the olfactory pathway, we lack a complete molecular characterization of the transcriptional events that occurs in this olfactory area during AD progression. To address this gap in knowledge, we have assessed the genome-wide expression in postmortem OBs from subjects with varying degree of AD pathology. A stage-dependent deregulation of specific pathways was observed, revealing transmembrane transport, and neuroinflammation as part of the functional modules that are disrupted across AD grading...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050226/cross-talk-mechanism-between-endothelial-cells-and-hepatocellular-carcinoma-cells-via-growth-factors-and-integrin-pathway-promotes-tumor-angiogenesis-and-cell-migration
#5
Tang Feng, Hongchi Yu, Qing Xia, Yunlong Ma, Hongmei Yin, Yang Shen, Xiaoheng Liu
Tumor angiogenesis plays a central role in the development and metastasis of hepatocellular carcinoma. Cancer cells secrete angiogenic factors to recruit vascular endothelial cells and sustain tumor vascular networks, which facilitate the migration and invasion of cancer cells. Therefore, the cross-talk between vascular endothelial cells and cancer cells is vitally necessary, however, little is known about the cross-talk mechanism of these cells interaction. In the present study, the proliferation, migration, invasion and tube formation of vascular endothelial EA...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050185/-optical-coherence-tomography-angiography-of-acute-vogt-koyanagi-harada-disease
#6
S S Jia, C Zhao, D Gong, Z Chen, M F Zhang
Objective: To measure vascular density in retinal and choroidal capillary layers by optical coherence tomography angiography (OCTA) and to explore their potential clinical values in Vogt-Koyanagi-Harada disease (VKH). Methods: This is a cross-sectional case-control study. Twenty-one acute VKH cases presented to Peking Union Medical College Hospital between April 2015 and July 2015 and 49 healthy controls were enrolled in this study. OCTA was performed with a split-spectrum amplitude-decorrelation angiography-optical coherence tomography (SSADA-OCT) system borrowed from Optovue Inc...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29050073/-clinicopathologic-features-of-three-cases-of-erythropoietic-protoporphyria-with-liver-involvement
#7
J Shi, X Q Li, Z H Lu
Objective: To investigate the clinicopathologic features of the erythropoietic protoporphyria (EPP) with liver involvement. Methods: The clinical findings and hepatic biopsy of 3 cases of EPP diagnosed between July, 2011 to August, 2014 with liver involvement were reviewed, with relevant literature review. Results: All patients presented with persistent and refractory abdominal pain, with obvious jaundice and deranged liver function. Imaging showed homogeneous hepatomegaly in all patients. Histologically, the hepatocytes were edematous, and contained numerous cytoplasmic globular brown pigments and bile pigments, which were also found in Kupffer cells, in the bile canaliculi and in some of dilated sinusoid...
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29049867/ion-pair-and-solvation-dynamics-of-bmim-bf4-water-system
#8
João Cascão, Wagner Silva, Ana S D Ferreira, Eurico J Cabrita
In this work, [Bmim][BF4 ]/water mixtures were analysed over the whole water composition (xw ) in order to study the rotational and translational behaviour of the ions. We employed a multinuclear NMR approach to determine anion/cation/water diffusion coefficients and longitudinal relaxation rates at different water content. In neat IL the cation diffuses faster than the anion and at low xw anions and cations share almost the same diffusion coefficient, but above a critical water concentration the anion begins to diffuse faster than the cation...
October 19, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29049690/surgical-treatment-of-postinfarction-ventricular-septal-defect-risk-factors-and-outcome-analysis
#9
Marek Pojar, Jan Harrer, Nedal Omran, Zdenek Turek, Jana Striteska, Jan Vojacek
OBJECTIVES: Postinfarction ventricular septal defect is a serious mechanical complication of acute myocardial infarction associated with high postoperative mortality. The aim of this study was to review our experience with surgical repair of postinfarction ventricular septal defect and to identify predictors of early and late outcomes. METHODS: Thirty-nine patients (19 men and 20 women, mean age 68.4 ± 9.9 years) with postinfarction ventricular septal defect who underwent surgical repair at our institution between 1996 and 2016 were retrospectively evaluated...
August 24, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049291/a-deep-convolutional-neural-network-for-classification-of-red-blood-cells-in-sickle-cell-anemia
#10
Mengjia Xu, Dimitrios P Papageorgiou, Sabia Z Abidi, Ming Dao, Hong Zhao, George Em Karniadakis
Sickle cell disease (SCD) is a hematological disorder leading to blood vessel occlusion accompanied by painful episodes and even death. Red blood cells (RBCs) of SCD patients have diverse shapes that reveal important biomechanical and bio-rheological characteristics, e.g. their density, fragility, adhesive properties, etc. Hence, having an objective and effective way of RBC shape quantification and classification will lead to better insights and eventual better prognosis of the disease. To this end, we have developed an automated, high-throughput, ex-vivo RBC shape classification framework that consists of three stages...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29049200/subclinical-atherosclerosis-and-history-of-cardiovascular-events-in-italian-patients-with-rheumatoid-arthritis-results-from-a-cross-sectional-multicenter-girrcs-gruppo-italiano-di-ricerca-in-reumatologia-clinica-e-sperimentale-study
#11
Piero Ruscitti, Domenico Paolo Emanuele Margiotta, Federica Macaluso, Daniela Iacono, Francesca D'Onofrio, Giacomo Emmi, Fabiola Atzeni, Marcella Prete, Federico Perosa, Piercarlo Sarzi-Puttini, Lorenzo Emmi, Francesco Paolo Cantatore, Giovanni Triolo, Antonella Afeltra, Roberto Giacomelli, Gabriele Valentini
Several studies have pointed out a significant association between rheumatoid arthritis (RA) and accelerated atherosclerosis. At the best of our knowledge, no such study has been carried out in a large Italian series and, in this study, we aimed to investigate the prevalence of both subclinical atherosclerosis and history of cardiovascular events (CVEs), in patients consecutively admitted from January 1, 2015 to December 31, 2015 to Rheumatology Units throughout the whole Italy.Centers members of GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) were invited to enrol patients consecutively admitted from January 1, 2015 to December 31, 2015 and satisfying American College of Rheumatology/ European League Against Rheumatism criteria for RA and to investigate each of them for: traditional cardiovascular risk factors: sex, age, smoking habit, total cholesterol, triglycerides, glycaemia, high blood pressure, metabolic syndrome (MS), type 2 diabetes (T2D); RA features: disease duration as assessed from the first symptom, disease activity as evaluated by DAS28, radiographic damage as assessed by hands and feet x-ray, and previous joint surgery; prevalence of both subclinical atherosclerosis and history of CVEs...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048923/protocol-design-for-large-scale-cross-sectional-studies-of-surveillance-of-risk-factors-of-non-communicable-diseases-in-iran-steps-2016
#12
Shirin Djalalinia, Mitra Modirian, Ali Sheidaei, Moein Yoosefi, Hossein Zokaiee, Bahman Damirchilu, Zohreh Mahmoudi, Negar Mahmoudi, Mohammad Javad Hajipour, Niloofar Peykari, Nazila Rezaei, Rosa Haghshenas, Mohammad Hossein Mohammadi, Alireza Delavari, Mohammad Mehdi Gouya, Shohreh Naderimagham, Ahmad Kousha, Alireza Moghisi, Alireza Mahdavihezaveh, Kambiz Abachizadeh, Reza Majdzadeh, Ali Akbar Sayyari, Reza Malekzadeh, Bagher Larijani, Farshad Farzadfar
INTRODUCTION: The rise in non-communicable diseases (NCDs) has gained increasing attention. There is a great need for reliable data to address such problems. Here, we describe the development of a comprehensive set of executive and scientific protocols and instructions of STEPs 2016. METHODS/DESIGN: This is a large-scale cross-sectional study of Surveillance of Risk Factors of NCDs in Iran. Through systematic proportional to size cluster random sampling, 31,050 participants enrolled in three sequential processes, of completing questionnaires; physical measurements, and lab assessment...
September 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29048518/disease-related-predictors-of-health-related-quality-of-life-in-youth-with-eosinophilic-esophagitis
#13
Mary K Lynch, Margaux J Barnes, Reed A Dimmitt, Lisa Martin, Marc E Rothenberg, Burel R Goodin
Objective: To evaluate relations between health-related quality of life (HRQoL) and clinical symptom presentation in youth with eosinophilic esophagitis (EoE). We hypothesized that presence of dysphagia, reflux, nausea/vomiting, and epigastric pain would be related to poorer HRQoL. In predictive models, it was hypothesized that dysphagia, reflux, nausea/vomiting, and epigastric pain would each significantly and uniquely predict poorer HRQoL. Methods: This cross-sectional, two-study design included 91 dyads comprised children with EoE and their respective caregivers across two tertiary children's hospitals, Site 1 in the Midwest (N = 47) and Site 2 in the Deep South (N = 44)...
October 12, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29048448/exposure-to-individual-and-multiple-carcinogenic-metals-during-paediatric-age-an-experience-from-an-italian-urban-scenario
#14
C Protano, M L Astolfi, S Canepari, R Andreoli, A Mutti, F Valeriani, V Romano Spica, A Antonucci, V Mattei, S Martellucci, M Vitali
BACKGROUND: Exposure to single and multiple carcinogenic metals and/or semimetals represents a major environmental risk factor for public health. In particular, children are more susceptible to environmental pollutants than adults, but specific studies are still limited. The aims of the present study were: 1) to trace the exposure and co-exposure profiles to eight known or suspected carcinogenic metals and semimetals (As, Be, Cd, Co, Cr, Ni, Pb, and Sb); and: 2) to evaluate the influence of some possible interfering/confounding factors on the exposure to these elements during childhood...
November 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29048373/individual-and-environmental-correlates-to-quality-of-life-in-park-users-in-colombia
#15
Diana Marina Camargo, Paula Camila Ramírez, Rogério César Fermino
Purpose: To explore individual and environmental correlates to quality of life (QoL) in park users in Colombia. Methods: A cross-sectional study with face-to-face interviews was conducted with 1392 park users from ten parks in Colombia. The survey included sociodemographic questions, health condition assessed with EuroQuol-5-Dimensions-5-Levels; in addition, questions about accessibility to the parks and perceptions about quality of infrastructure and green areas were asked. The Spanish version of the questionnaire EUROHIS-QOL-8 items was applied to assess QoL...
October 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29048302/pre-symptomatic-testing-for-neurodegenerative-disorders-middle-to-long-term-psychopathological-impact
#16
Susana Lêdo, Ângela Leite, Teresa Souto, Maria A Pimenta Dinis, Jorge Sequeiros
BACKGROUND: Over the past 20 years, studies have revealed that the communication of a pre-symptomatic test (PST) result for late-onset diseases, such as Huntington’s disease (HD), doesn’t cause psychological disturbance. This cross-sectional study investigated the middle- (4 years) to long-term (7 and 10 years) psychological impact of PST for 3 autosomal dominant late-onset diseases: HD, Machado-Joseph disease (DMJ) and familial amyloid polyneuropathy (FAP). METHOD: The study included 203 subjects: 170 (84%) agreed to make the PST for FAP, 29 (14%) for HD and 4 (2%) for MJD...
November 2017: Psicothema
https://www.readbyqxmd.com/read/29048200/automated-quantification-of-the-landing-error-scoring-system-with-a-markerless-motion-capture-system
#17
Timothy C Mauntel, Darin A Padua, Laura E Stanley, Barnett S Frank, Lindsay J DiStefano, Karen Y Peck, Kenneth L Cameron, Stephen W Marshall
CONTEXT:   The Landing Error Scoring System (LESS) can be used to identify individuals with an elevated risk of lower extremity injury. The limitation of the LESS is that raters identify movement errors from video replay, which is time-consuming and, therefore, may limit its use by clinicians. A markerless motion-capture system may be capable of automating LESS scoring, thereby removing this obstacle. OBJECTIVE:   To determine the reliability of an automated markerless motion-capture system for scoring the LESS...
October 19, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/29048189/sex-related-marijuana-expectancies-as-predictors-of-sexual-risk-behavior-following-smoked-marijuana-challenge
#18
Linda M Skalski, Rachel L Gunn, Amy Caswell, Stephen Maisto, Jane Metrik
Marijuana use has been associated with sexual risk behavior, but the mechanisms that underlie this relationship are not well understood. The present study examined whether marijuana acutely increased sexual risk on a behavioral decision-making task and whether sex-related marijuana outcome expectancies influenced sexual risk decisions after marijuana administration. Participants were heterosexual marijuana users (n = 126) who were randomly assigned to 1 of 4 study conditions using a 2 × 2 factorial design crossing drug administration (received 2...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29048166/an-atomistic-explanation-for-interlayer-charge-transfer-in-metal-semiconductor-nanocomposites-the-case-of-silver-and-anatase
#19
Giovanni DI Liberto, Valentina Pifferi, Leonardo Lo Presti, Michele Ceotto, Luigi Falciola
A concerted theoretical and experimental investigation of the silver/anatase hybrid nanocomposite, a very promising material for advanced sensing applications, is presented. We measure its exceptional electrochemical virtues in terms of current densities and reproducibility, providing their explanation at the atomic-scale level, and demonstrating how and why silver acts as a positive electrode. Using periodic plane-wave DFT calculations, we estimate the overall amount of electron transfer toward the semiconductor side of the interface at equilibrium...
October 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29048100/circadian-gene-hclock-contributes-to-progression-of-colorectal-carcinoma-and-is-directly-regulated-by-tumor%C3%A2-suppressive-microrna%C3%A2-124
#20
Jia-Zi Yu, Ning Sun, Yi-Bing Bei, Xiao-Bo Li, Chao Lu, Lu-Chun Hua
An abundance of studies has demonstrated that disruption of circadian rhythms is one of the factors that may contribute to the initiation and development of human colorectal carcinomas (CRCs). Recently, microRNA‑124 has been demonstrated to suppress tumor growth or metastasis of CRCs. However, the mechanisms of cross‑talk between microRNA‑124 (miR‑124) and circadian rhythms in the regulation of CRCs are poorly understood. The present study demonstrated that the protein expression levels of human circadian locomoter output cycles protein kaput (hCLOCK) is significantly increased, while miR‑124 is attenuated in high‑grade human CRC tissues and in the more invasive colorectal cancer cell lines SW620 and LOVO...
September 25, 2017: Molecular Medicine Reports
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