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https://www.readbyqxmd.com/read/29909342/fak-and-bmp-9-synergistically-trigger-osteogenic-differentiation-and-bone-formation-of-adipose-derived-stem-cells-through-enhancing-wnt-%C3%AE-catenin-signaling
#1
Cheng Yuan, Xiaoli Gou, Jiang Deng, Zhijun Dong, Peng Ye, Zhenming Hu
BACKGROUNDS: Adipose derived stem cells (ADSCs) could undergo osteogenesis via focal adhesion kinase (FAK) and bone morphogenetic protein (BMP) 9 signals, both of which could affect Wnt-β-catenin signal, a signal pathway closely related to ADSCs osteogenesis. It's still enigma whether FAK and BMP-9 contribute to osteogenesis. Here, we examined the effect of FAK on BMP9-inducedosteogenic differentiation, unveiled the possible molecular mechanism underling this process. METHODS: In the present study, ADSCs were isolated and purified, and cells of passage 3 underwent virus mediated transfection to prepare ADSCs with stable FAK shRNA expression...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29909303/quality-of-life-in-stabilized-outpatients-with-bipolar-i-disorder-associations-with-resilience-internalized-stigma-and-residual-symptoms
#2
Fabienne Post, Silvia Pardeller, Beatrice Frajo-Apor, Georg Kemmler, Catherine Sondermann, Armand Hausmann, W Wolfgang Fleischhacker, Yuya Mizuno, Hiroyuki Uchida, Alex Hofer
OBJECTIVES: Improving Quality of Life (QoL) is an important objective in the treatment of bipolar disorder. The aim of the current study was to examine to which extent resilience, internalized stigma, and psychopathology are correlated to QoL. METHODS: We recruited 60 outpatients diagnosed with bipolar I disorder according to DSM-IV criteria and 77 healthy control subjects from the general community. In patients, symptoms were quantified by the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Young Mania Rating Scale (YMRS) and internalized stigma by the Internalized Stigma of Mental Illness (ISMI) scale...
May 29, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29909231/effects-of-unstable-shoes-on-trunk-muscle-activity-in-patients-with-chronic-low-back-pain
#3
P Salvador-Coloma, M D Arguisuelas, J Doménech-Fernández, D Sánchez-Zuriaga, J J Amer-Cuenca, J Martínez-Gramage, F J Montañez-Aguilera, J F Lisón
INTRODUCTION: Unstable shoes were developed as a walking device to strengthen the lower extremity muscles and reduce joint loading. Many studies have reported increased muscle activity throughout the gait cycle in most of the lower limb muscles in healthy adults using these shoes. However, no previous studies have explored the effects of wearing unstable shoes on trunk muscle activity in patients with chronic low back pain (CLBP). Therefore, the aim of the present study was to compare the activity of selected trunk muscles in patients with CLBP during a gait test while walking wearing unstable shoes or conventional flat shoes (control)...
June 11, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29909190/pediatric-robotic-assisted-laparoscopic-pyeloplasty-does-age-matter
#4
T Kawal, A K Srinivasan, D Shrivastava, J Van Batavia, D Weiss, C Long, A R Shukla
BACKGROUND: Although shown to be safe in infancy, robotic-assisted laparoscopic pyeloplasty (RALP) for ureteropelvic junction obstruction (UPJO) is most commonly performed in older children and adolescents. OBJECTIVE: This study examined a contemporary RALP experience at a single tertiary pediatric center and compared outcomes in infants aged ≤1 year with an older cohort. METHODS AND DESIGN: All RALP procedures were entered into an Institutional Review Board-approved data registry from 2012 to 2016...
June 1, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29909081/-13-c-%C3%A2-1-h-transfer-of-light-induced-hyperpolarization-allows-for-selective-detection-of-protons-in-frozen-photosynthetic-reaction-center
#5
Pavlo Bielytskyi, Daniel Gräsing, Kaustubh R Mote, Karthick Babu Sai Sankar Gupta, Shimon Vega, P K Madhu, A Alia, Jörg Matysik
In the present study, we exploit the light-induced hyperpolarization occurring on 13 C nuclei due to the solid-state photochemically induced dynamic nuclear polarization (photo-CIDNP) effect to boost the NMR signal intensity of selected protons via inverse cross-polarization. Such hyperpolarization transfer is implemented into 1 H-detected two-dimensional 13 C-1 H correlation magic-angle-spinning (MAS) NMR experiment to study protons in frozen photosynthetic reaction centers (RCs). As a first trial, the performance of such an experiment is tested on selectively 13 C labeled RCs from the purple bacteria of Rhodobacter sphaeroides...
June 8, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29908893/post-pegylated-and-crosslinked-polymeric-ssrna-nanocomplexes-as-adjuvants-targeting-lymph-nodes-with-increased-cytolytic-t-cell-inducing-properties
#6
Bo Lou, Ans De Beuckelaer, George R Dakwar, Katrien Remaut, Johan Grooten, Kevin Braeckmans, Bruno G De Geest, Enrico Mastrobattista, Stefaan De Koker, Wim E Hennink
Potent adjuvants are highly demanded for most protein and peptides based vaccine candidates in clinical development. Recognition of viral single stranded (ss)RNA by innate toll-like receptors 7/8 in dendritic cells results in a cytokine environment supportive to the establishment of long lasting antibody responses and Th1 oriented T cell immunity. To fully exploit the immunestimulatory properties of ssRNA, it needs to be adequately formulated to ensure its optimal delivery to dendritic cells in the vaccine draining lymph nodes...
June 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29908694/arterial-stiffness-in-ckd-a-review
#7
REVIEW
Raymond R Townsend
This narrative review summarizes a decade of experience examining the cross-sectional and longitudinal relationships of arterial stiffness, as assessed using carotid-femoral pulse wave velocity, with outcomes in patients with chronic kidney disease enrolled in the Chronic Renal Insufficiency Cohort. Our goal is to review the importance of the pulse wave contour and pulse wave velocity and present data on the reproducibility of pulse wave velocity measurements, determinants of pulse wave velocity, and the relationship that velocity measurements have with longitudinal kidney and cardiovascular outcomes...
June 13, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29908680/interactions-between-dietary-inflammatory-index-nutritional-state-and-multiple-sclerosis-clinical-condition
#8
Bruna Yhang Da Costa Silva, Helena Alves De Carvalho Sampaio, Nitin Shivappa, James Hébert, Larissa Da Silva Albuquerque, Antônio Augusto Ferreira Carioca, José Artur Costa D'Almeida, Carla Soraya Costa Maia, Maria Luisa Pereira De Melo
BACKGROUND & AIMS: The Dietary Inflammatory Index (DII) consists of a tool that assesses dietary inflammatory potential based on the assignment of an inflammatory score to a variety of nutrients, seasonings and bioactive compounds. Pro-inflammatory diets are associated to weight and abdominal fat excess. High Body Mass Index (BMI) and Waist Circumference (WC) seem to contribute to a worse prognosis in Multiple Sclerosis (MS) patients. Therefore, this study seeks to investigate the relation between anthropometric indexes and body adiposity with the clinical condition and the Dietary Inflammatory Index of MS individuals...
August 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29908514/sdvsrm-a-new-ssrm-based-technique-featuring-dynamically-adjusted-scanner-synchronized-sample-voltages-for-measurement-of-actively-operated-devices
#9
Stefan Doering, Andre Wachowiak, Hagen Roetz, Stefan Eckl, Thomas Mikolajick
Scanning spreading resistance microscopy (SSRM) with its high spatial resolution and high dynamic signal range is a powerful tool for two-dimensional characterization of semiconductor dopant areas. However, the application of the method is limited to devices in equilibrium condition, as the investigation of actively operated devices would imply potential differences within the device, whereas SSRM relies on a constant voltage difference between sample surface and probe tip. Furthermore, the standard preparation includes short circuiting of all device components, limiting applications to devices in equilibrium condition...
June 1, 2018: Ultramicroscopy
https://www.readbyqxmd.com/read/29908467/a-french-hernia-in-dubai-a-case-report
#10
Yousif H Al Abboudi, Hajer A Busharar, Labib S Alozaibi, Asnin Shah, Rafya Ahmed
INTRODUCTION: De Garengeot hernia was first described in 1731. It is rare type of hernia and there is no established mode of treatment for it to date. This work has been reported in line with the SCARE criteria (Agha et al., 2016). PRESENTATION OF CASE: We present a case of a 72 years old male with a non-reducible right inguinal swelling diagnosed to be a femoral hernia with congested appendix within. There are less than 100 cases like this reported to date in the literature...
May 31, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29908458/body-burden-of-toxic-metals-and-rare-earth-elements-in-non-smokers-cigarette-smokers-and-electronic-cigarette-users
#11
Mihaela Badea, Octavio P Luzardo, Ana González-Antuña, Manuel Zumbado, Liliana Rogozea, Laura Floroian, Dana Alexandrescu, Marius Moga, Laura Gaman, Mariana Radoi, Luis D Boada, Luis Alberto Henríquez-Hernández
Smoking is considered an important source for inorganic elements, most of them toxic for human health. During the last years, there has been a significant increase in the use of e-cigarettes, although the role of them as source of inorganic elements has not been well established. A cross-sectional study including a total of 150 subjects from Brasov (Romania), divided into three groups (non-smokers, cigarette smokers and electronic cigarettes smokers) were recruited to disclose the role of smoking on the human exposure to inorganic elements...
June 13, 2018: Environmental Research
https://www.readbyqxmd.com/read/29908457/sleep-disorders-among-yusho-patients-highly-intoxicated-with-dioxin-related-compounds-a-140-case-series
#12
Hideaki Kondo, Keiko Tanio, Yuki Nagaura, Mako Nagayoshi, Chikage Mitoma, Masutaka Furue, Takahiro Maeda
PURPOSE: Patients with Yusho, a condition caused by exposure to dioxins and dioxin-like compounds, have diverse mental and physical complaints. However, the relationship between dioxins and sleep disorders has not yet been examined. This cross-sectional study was designed to investigate problems associated with sleep among patients with Yusho. METHODS: A total of 140 participants (52.9% men, average age: 67.1 ± 12.2 years) were examined using questionnaires and medical interviews by an expert on sleep medicine...
June 13, 2018: Environmental Research
https://www.readbyqxmd.com/read/29908355/medial-acetabular-wall-breach-in-total-hip-arthroplasty-is-full-weight-bearing-possible
#13
Filippo Mandelli, Simon Tiziani, Jürgen Schmitt, Clément M L Werner, Hans-Peter Simmen, Georg Osterhoff
BACKGROUND: A breach of the medial acetabular wall is a phenomenon seen frequently due to over-reaming during total hip arthroplasty (THA). The consequences of this issue are not fully understood particularly in cementless THA. A retrospective study was performed to answer whether: 1) immediate postoperative full-weight bearing in the presence of a medial acetabular wall breach after THA results in more short-term revisions of the acetabular component, 2) increases the risk for migration of the acetabular component? HYPOTHESIS: Immediate full-weight bearing in the presence of a medial breach is not associated with an increased likelihood for acetabular-related revision surgery or migration of the cup...
June 13, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29908227/hypogastric-preservation-using-retrograde-endovascular-bypass
#14
Mathew Wooster, Paul Armstrong, Martin Back
OBJECTIVE: Maintenance of pelvic circulation has been connected to reduced risks of ischemic colitis, buttock claudication, erectile dysfunction, and spinal cord ischemia during the treatment of extensive aorto-iliac aneurysmal disease. We evaluate the mid to late follow up of a cohort of patients treated using one preservation technique, the endovascular external (EIA) to internal (IIA) iliac artery bypass. METHODS: All patients undergoing elective retrograde EIA-IIA endovascular bypass at a single institution were retrospectively reviewed over a ten-year period from 2006-2016...
June 13, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29908130/designed-macrocyclic-peptides-as-nanomolar-amyloid-inhibitors-based-on-minimal-recognition-elements
#15
Anna Spanopoulou, Luzia Heidrich, Hong-Ru Chen, Christina Frost, Dean Hrle, Eleni Malideli, Kathleen Hille, Alexandros Grammatikopoulos, Jürgen Bernhagen, Martin Zacharias, Gerhard Rammes, Aphrodite Kapurniotu
Amyloid self-assembly is linked to the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes (T2D), but so far none of the anti-amyloid molecules has reached the clinic. Macrocyclic peptides belong to the most attractive drug candidates. Here we present macrocyclic peptides (MCIPs) designed using minimal IAPP-derived recognition elements as a novel class of nanomolar amyloid inhibitors of both Abeta40(42) and IAPP or Abeta40(42) alone and show that chirality controls inhibitor selectivity. Sequence optimization led to the discovery of an Abeta40(42)-selective MCIP exhibiting high proteolytic stability in human plasma and human blood-brain-barrier (BBB) crossing ability in a cell model, two highly desirable properties for anti-amyloid drugs in AD...
June 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29908056/probabilistic-discrete-event-systems-modeling-of-nonlinear-transitions-between-electronic-and-combustible-cigarette-smoking-with-the-2014-national-youth-tobacco-survey-data
#16
Xinguang Chen, Bin Yu, Ding-Geng Chen
A growing number of young people smoke electronic (e-) cigarettes, presenting an emerging challenge to tobacco control. Analyses are needed to better understand the dynamics of mutual transitions between e-cigarette and conventional combustible (c-) cigarette smoking to advance evidence-based tobacco control. In this study we modeled the nonlinear dynamics of c- and e-cigarette smoking behavior transitions using the 2014 National Youth Tobacco Survey (NYTS) data. A model with five Markov-Chain transition stages linked by 21 transitional paths/probabilities was constructed, guided by the probabilistic discrete event systems (PDES) theory...
July 2018: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/29907924/heat-acclimation-increases-inflammatory-and-apoptotic-responses-to-subsequent-lps-challenge-in-c2c12-myotubes
#17
Meghan G Patton, Trevor L Gillum, Mandy C Szymanski, Lacey M Gould, Claire J Lauterbach, Roger A Vaughan, Matthew R Kuennen
This work investigated the ability of a 6-day heat acclimation protocol to impart heat acclimation-mediated cross-tolerance (HACT) in C2C12 myotubes, as indicated by changes in inflammatory and apoptotic responses to subsequent lipopolysaccharide (LPS) challenge. Myotubes were incubated at 40 °C for 2 h/day over 6 days (HA) or maintained for 6 days at 37 °C (C). Following 24 h recovery, myotubes from each group received either no stimulation or 500 ng/ml LPS for 2 h (HA + LPS and C + LPS, respectively)...
June 16, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29907890/impact-of-mast-cells-in-depression-disorder-inhibitory-effect-of-il-37-new-frontiers
#18
REVIEW
Pio Conti, Alessandro Caraffa, Gianpaolo Ronconi, Chiara M Conti, Spiros K Kritas, Filiberto Mastrangelo, Lucia Tettamanti, Theoharis C Theoharides
The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and thoughts is a major risk factor for several metabolic diseases and may influence the physiology of the body leading to depression. Depression, present in mastocytosis, is an important endogenous process that promotes the activation of meningeal cell receptors through a low-grade neurogenic chronic inflammation, and MCs...
June 16, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29907654/nadph-oxidase-5-is-a-pro-contractile-nox-isoform-and-a-point-of-cross-talk-for-calcium-and-redox-signaling-implications-in-vascular-function
#19
Augusto C Montezano, Livia De Lucca Camargo, Patrik Persson, Francisco J Rios, Adam P Harvey, Aikaterini Anagnostopoulou, Roberto Palacios, Ana Caroline P Gandara, Rheure Alves-Lopes, Karla B Neves, Maria Dulak-Lis, Chet E Holterman, Pedro Lagerblad de Oliveira, Delyth Graham, Christopher Kennedy, Rhian M Touyz
BACKGROUND: NADPH Oxidase 5 (Nox5) is a calcium-sensitive superoxide-generating Nox. It is present in lower forms and higher mammals, but not in rodents. Nox5 is expressed in vascular cells, but the functional significance remains elusive. Given that contraction is controlled by calcium and reactive oxygen species, both associated with Nox5, we questioned the role of Nox5 in pro-contractile signaling and vascular function. METHODS AND RESULTS: Transgenic mice expressing human Nox5 in a vascular smooth muscle cell-specific manner (Nox5 mice) and Rhodnius prolixus , an arthropod model that expresses Nox5 endogenoulsy, were studied...
June 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29907526/invasive-eeg-electrodes-in-presurgical-evaluation-of-epilepsies-systematic-analysis-of-implantation-video-eeg-monitoring-and-explantation-related-complications-and-review-of-literature
#20
Laurent M Willems, Philipp S Reif, Andrea Spyrantis, Adriano Cattani, Thomas M Freiman, Volker Seifert, Marlies Wagner, Se-Jong You, Susanne Schubert-Bast, Sebastian Bauer, Karl Martin Klein, Felix Rosenow, Adam Strzelczyk
INTRODUCTION: Stereoelectroencephalography (sEEG) is a diagnostic procedure for patients with refractory focal epilepsies that is performed to localize and define the epileptogenic zone. In contrast to grid electrodes, sEEG electrodes are implanted using minimal invasive operation techniques without large craniotomies. Previous studies provided good evidence that sEEG implantation is a safe and effective procedure; however, complications in asymptomatic patients after explantation may be underreported...
June 13, 2018: Epilepsy & Behavior: E&B
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