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https://www.readbyqxmd.com/read/28092774/the-lonely-road-to-paranoia-a-path-analytic-investigation-of-loneliness-and-paranoia
#1
Fabian Lamster, Tania M Lincoln, Clara M Nittel, Winfried Rief, Stephanie Mehl
Loneliness and paranoia are related, but the mechanisms that link them to each other remain unclear. Systematic reviews on loneliness propose a social-cognitive model in which loneliness leads to negative evaluations of other persons and a lack of interpersonal trust. However, the data discussed in these reviews are based on healthy individuals. Building on this model, the present study investigated 1) whether negative interpersonal schemata mediate the association between loneliness and paranoia and 2) whether a low level of perceived social support and less frequent social contact are related to loneliness...
January 2, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28092762/a-novel-approach-for-exposure-assessment-in-air-pollution-epidemiological-studies-using-neuro-fuzzy-inference-systems-comparison-of-exposure-estimates-and-exposure-health-associations
#2
Victoria Blanes-Vidal, Manuella Lech Cantuaria, Esmaeil S Nadimi
Many epidemiological studies have used proximity to sources as air pollution exposure assessment method. However, proximity measures are not generally good surrogates because of their complex non-linear relationship with exposures. Neuro-fuzzy inference systems (NFIS) can be used to map complex non-linear systems, but its usefulness in exposure assessment has not been extensively explored. We present a novel approach for exposure assessment using NFIS, where the inputs of the model were easily-obtainable proximity measures, and the output was residential exposure to an air pollutant...
January 13, 2017: Environmental Research
https://www.readbyqxmd.com/read/28092392/the-in-silico-identification-of-human-bile-salt-export-pump-abcb11-inhibitors-associated-with-cholestatic-drug-induced-liver-injury
#3
Lili Xi, Jia Yao, Yuhui Wei, Xin'an Wu, Xiaojun Yao, Huanxiang Liu, Shuyan Li
Drug-induced liver injury (DILI) is one of the major causes of drug attrition and failure. Currently, there is increasing evidence that direct inhibition of the human bile salt export pump (BSEP/ABCB11) by drugs and/or metabolites is one of the most important mechanisms of cholestatic DILI. In the present study, we employ two in silico methods, random forest (RF) and the pharmacophore method, to recognize potential BSEP inhibitors that could cause cholestatic DILI, with the aim of mitigating the risk of cholestatic DILI to some extent...
January 16, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28092260/-down-syndrome-and-heart-block-secondary-to-neonatal-lupus
#4
Carla Lucila Illana-Bravo, Socorro Méndez-Martínez, María Enriqueta Juan-Martínez
In Down syndrome, so far, has not been reported it's association with congenital heart block, this entity is rare and occurred in only 1% of mothers who have systemic lupus erythematosus, the presence of anti-Ro antibodies cross the placenta presenting neonatal lupus with skin lesions and congenital heart block, bradycardia, which is why we describe the following case. This is a new male end product of asymptomatic young mother, but serological birth with stigmata of Down syndrome, birth presents congenital bradycardia rare manifestation abnormalities, but common in children of mothers with lupus are initiated study protocol, realizing you including laboratory tests and immunological studies cabinet as electrocardiogram and echocardiogram, which gave tone to take the mother immunological studies, being positive antiRo...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28092235/hospital-cost-and-length-of-stay-in-idiopathic-pulmonary-fibrosis
#5
Joshua J Mooney, Karina Raimundo, Eunice Chang, Michael S Broder
OBJECTIVE: To provide a detailed picture of the economic impact of hospitalization in idiopathic pulmonary fibrosis (IPF) and to identify factors associated with cost and length of stay (LOS). METHODS: In this retrospective cross-sectional study using the Nationwide Inpatient Sample (NIS), we included hospitalizations for IPF (ICD-9-CM 516.3) with a principal diagnosis of respiratory disease (ICD-9-CM 460-519) from 2009-2011; lung transplant admissions were excluded...
January 16, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28091870/perspectives-using-polymer-modeling-to-understand-the-formation-and-function-of-nuclear-compartments
#6
REVIEW
N Haddad, D Jost, C Vaillant
Compartmentalization is a ubiquitous feature of cellular function. In the nucleus, early observations revealed a non-random spatial organization of the genome with a large-scale segregation between transcriptionally active-euchromatin-and silenced-heterochromatin-parts of the genome. Recent advances in genome-wide mapping and imaging techniques have strikingly improved the resolution at which nuclear genome folding can be analyzed and have revealed a multiscale spatial compartmentalization with increasing evidences that such compartment may indeed result from and participate to genome function...
January 14, 2017: Chromosome Research
https://www.readbyqxmd.com/read/28091847/using-the-newly-developed-floor-sitting-movement-analysis-proforma-to-study-the-effect-of-age-and-activity-on-floor-sitting-in-indian-adults
#7
Anjana Nagrajan, Sebestina A D'Souza
Floor-sitting is culturally relevant to the Indian context. The present study aimed to examine the effect of age and activity on the movement patterns used and time taken to perform floor-sitting in Indian adults. Video-recordings of 30 young (23.30 ± 2.53 years) and 30 older (69.67 ± 6.45 years) adults performing floor-sitting without and with an activity (simulated feeding) were analyzed using the Floor-sitting Movement Analysis Proforma (FMAP) developed for the study. For inter-rater reliability of the FMAP, two raters analyzed the performance of a random sample of 20 participants...
January 16, 2017: Journal of Cross-cultural Gerontology
https://www.readbyqxmd.com/read/28091677/model-cheese-aroma-perception-is-explained-not-only-by-in-vivo-aroma-release-but-also-by-salivary-composition-and-oral-processing-parameters
#8
E Guichard, M Repoux, E M Qannari, H Laboure, G Feron
The aim of the present paper was to determine, from four model cheeses differing in fat content and firmness and consumed by fourteen well characterised subjects, the respective impacts of in vivo aroma release, bolus rheology, chewing activity, mouth coating and salivary composition on dynamic aroma perception. The originality of the approach is that it considers all the parameters together and is able to evaluate their relative contribution using multi-block partial least square (MB-PLS) regression. The fruity aroma perception of the more hydrophilic compound (ethyl propanoate) was related to its dynamic release parameters before swallowing whereas the blue cheese aroma perception of the more hydrophobic compound (nonan-2-one) was related to its dynamic release parameters after swallowing and was highly impacted by mouth coating...
January 16, 2017: Food & Function
https://www.readbyqxmd.com/read/28091593/economic-development-and-forest-cover-evidence-from-satellite-data
#9
Jesús Crespo Cuaresma, Olha Danylo, Steffen Fritz, Ian McCallum, Michael Obersteiner, Linda See, Brian Walsh
Ongoing deforestation is a pressing, global environmental issue with direct impacts on climate change, carbon emissions, and biodiversity. There is an intuitive link between economic development and overexploitation of natural resources including forests, but this relationship has proven difficult to establish empirically due to both inadequate data and convoluting geo-climactic factors. In this analysis, we use satellite data on forest cover along national borders in order to study the determinants of deforestation differences across countries...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091585/microrna-19b-is-a-potential-biomarker-of-increased-myocardial-collagen-cross-linking-in-patients-with-aortic-stenosis-and-heart-failure
#10
Javier Beaumont, Begoña López, Susana Ravassa, Nerea Hermida, Gorka San José, Idoia Gallego, Félix Valencia, Juan José Gómez-Doblas, Eduardo de Teresa, Javier Díez, Arantxa González
This study analyzed the potential associations of 7 myocardial fibrosis-related microRNAs with the quality of the collagen network (e.g., the degree of collagen fibril cross-linking or CCL) and the enzyme lysyl oxidase (LOX) responsible for CCL in 28 patients with severe aortic stenosis (AS) of whom 46% had a diagnosis of chronic heart failure (HF). MicroRNA expression was analyzed in myocardial and blood samples. From the studied microRNAs only miR-19b presented a direct correlation (p < 0.05) between serum and myocardium...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091568/identification-of-misexpressed-genetic-elements-in-hybrids-between-drosophila-related-species
#11
Hélène Lopez-Maestre, Elias A G Carnelossi, Vincent Lacroix, Nelly Burlet, Bruno Mugat, Séverine Chambeyron, Claudia M A Carareto, Cristina Vieira
Crosses between close species can lead to genomic disorders, often considered to be the cause of hybrid incompatibility, one of the initial steps in the speciation process. How these incompatibilities are established and what are their causes remain unclear. To understand the initiation of hybrid incompatibility, we performed reciprocal crosses between two species of Drosophila (D. mojavensis and D. arizonae) that diverged less than 1 Mya. We performed a genome-wide transcriptomic analysis on ovaries from parental lines and on hybrids from reciprocal crosses...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091562/unravelling-a-simple-method-for-the-low-temperature-synthesis-of-silicon-nanocrystals-and-monolithic-nanocrystalline-thin-films
#12
Ka-Hyun Kim, Erik V Johnson, Andrey G Kazanskii, Mark V Khenkin, Pere Roca I Cabarrocas
In this work, we present new results on the plasma processing and structure of hydrogenated polymorphous silicon (pm-Si:H) thin films. pm-Si:H thin films consist of a low volume fraction of silicon nanocrystals embedded in a silicon matrix with medium range order, and they possess this morphology as a significant contribution to their growth comes from the impact on the substrate of silicon clusters and nanocrystals synthesized in the plasma. Quadrupole mass spectrometry, ion flux measurements, and material characterization by transmission electron microscopy (TEM) and atomic force microscopy all provide insight on the contribution to the growth by silicon nanocrystals during PECVD deposition...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091349/intranasal-oxytocin-increases-facial-expressivity-but-not-ratings-of-trustworthiness-in-patients-with-schizophrenia-and-healthy-controls
#13
J D Woolley, B Chuang, C Fussell, S Scherer, B Biagianti, D Fulford, D H Mathalon, S Vinogradov
BACKGROUND: Blunted facial affect is a common negative symptom of schizophrenia. Additionally, assessing the trustworthiness of faces is a social cognitive ability that is impaired in schizophrenia. Currently available pharmacological agents are ineffective at improving either of these symptoms, despite their clinical significance. The hypothalamic neuropeptide oxytocin has multiple prosocial effects when administered intranasally to healthy individuals and shows promise in decreasing negative symptoms and enhancing social cognition in schizophrenia...
January 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28090808/biomaterial-encapsulation-is-enhanced-in-the-early-stages-of-the-foreign-body-reaction-during-conditional-macrophage-depletion-in-transgenic-mafia-mice
#14
Ruud A Bank, Jurjen Zandstra, Hilde Room, Arjen H Petersen, Sander Maarten van Putten
Macrophages are pivotal cells during the foreign body reaction, as they orchestrate the pro-inflammatory microenvironment inside and around biomaterials by secretion of inflammatory mediators. Furthermore they are responsible for the degradation of biomaterials and are thought to instruct the fibroblasts that generate a fibrous capsule around implanted biomaterials. In this study we investigated the events during the FBR when macrophages are not present. Hexamethylenediisocyanate cross-linked collagen scaffolds were implanted in "Macrophage Fas-Induced Apoptosis" (MaFIA) mice, which allow "on demand" macrophage depletion...
January 15, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28090699/modelling-irf8-deficient-human-hematopoiesis-and-dendritic-cell-development-with-engineered-ips-cells
#15
Stephanie Sontag, Malrun Förster, Jie Qin, Paul Wanek, Saskia Mitzka, Herdit M Schüler, Steffen Koschmieder, Stefan Rose-John, Kristin Seré, Martin Zenke
Human induced pluripotent stem (iPS) cells can differentiate into cells of all three germ layers, including hematopoietic stem cells and their progeny. Interferon regulatory factor 8 (IRF8) is a transcription factor, which acts in hematopoiesis as lineage determining factor for myeloid cells, including dendritic cells (DC). Autosomal recessive or dominant IRF8 mutations occurring in patients cause severe monocytic and DC immunodeficiency. To study IRF8 in human hematopoiesis we generated human IRF8-/- iPS cells and IRF8-/- embryonic stem (ES) cells using RNA guided CRISPR/Cas9n genome editing...
January 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28090445/population-reference-range-for-developmental-lumbar-spinal-canal-size
#16
James F Griffith, Junbin Huang, Sheung-Wai Law, Fan Xiao, Jason Chi Shun Leung, Defeng Wang, Lin Shi
BACKGROUND: Considerable variability exists in normal developmental lumbar spinal canal size. This impacts the likelihood of neural compromise. Spinal canal development is complete by 17 years. As diseases incurred thereafter do not knowingly affect the developmental size of the spinal canal, it is reasonable to use a selected population undergoing abdominopelvic computed tomography (CT) examination to determine developmental lumbar spinal canal size. METHODS: Study approval was granted by the Clinical Research Ethics Committee...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28090336/medical-feminism-working-mothers-and-the-limits-of-home-finding-a-balance-between-self-care-and-other-care-in-cross-cultural-debates-about-health-and-lifestyle-1952-1956
#17
Frederick Cooper
Post-war medical debates about the psychiatric consequences of married women's economic behaviour witnessed far more divergence and collision between perspectives than has often been acknowledged. Practitioners who approached women primarily as facilitators of family health-as wives and mothers-were mistrustful of the competing demands presented by paid employment. They were faced by a growing spectrum of opinion, however, which represented women as atrophying in the confines of domestic life, and which positioned work as a therapeutic act...
July 12, 2016: Palgrave Communications
https://www.readbyqxmd.com/read/28090319/the-role-of-liver-sinusoidal-cells-in-local-hepatic-immune-surveillance
#18
REVIEW
Dirk Wohlleber, Percy A Knolle
Although the liver's function as unique immune organ regulating immunity has received a lot of attention over the last years, the mechanisms determining hepatic immune surveillance against infected hepatocytes remain less well defined. Liver sinusoidal cells, in particular, liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs), serve as physical platform for recruitment and anchoring of blood-borne immune cells in the liver. Liver sinusoidal cells also function as portal of entry for infectious microorganisms targeting the liver such as hepatotropic viruses, bacteria or parasites...
December 2016: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28090147/regression-shrinkage-and-neural-models-in-predicting-the-results-of-400-metres-hurdles-races
#19
K Przednowek, J Iskra, A Maszczyk, M Nawrocka
This study presents the application of regression shrinkage and artificial neural networks in predicting the results of 400-metres hurdles races. The regression models predict the results for suggested training loads in the selected three-month training period. The material of the research was based on training data of 21 Polish hurdlers from the Polish National Athletics Team Association. The athletes were characterized by a high level of performance. To assess the predictive ability of the constructed models a method of leave-one-out cross-validation was used...
December 2016: Biology of Sport
https://www.readbyqxmd.com/read/28089902/olmesartan-with-azelnidipine-versus-with-trichlormethiazide-on-home-blood-pressure-variability-in-patients-with-type-ii-diabetes-mellitus
#20
Emi Ushigome, Shinobu Matsumoto, Chikako Oyabu, Hidetaka Ushigome, Isao Yokota, Goji Hasegawa, Naoto Nakamura, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui
The aim of the present study was to compare the effects of olmesartan combined with azelnidipine versus olmesartan combined with trichlormethiazide, on home blood pressure (BP) and pressure variability in type II diabetes mellitus patients using home BP telemonitoring system. We performed an open-label cross-over pilot study of 28 patients with type II diabetes mellitus. Patients received combination treatment with either olmesartan 20 mg plus azelnidipine 16 mg or olmesartan 20 mg plus trichlormethiazide 1 mg for more than 6 weeks each in a cross-over method...
December 22, 2016: Journal of the American Society of Hypertension: JASH
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