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Rumi Hisakata, Daisuke Hayashi, Ikuya Murakami
The static envelope of a Gabor patch with a moving sinusoidal carrier appears shifted in the direction of the carrier motion (De Valois & De Valois, 1991). This phenomenon is called motion-induced position shift. Although several motion-processing stages, ranging from low- to high-level processes, may contribute to position estimation, it is unknown whether a binocular matching stage or an even earlier stage exerts an influence. To elucidate this matter, we investigated the disparity tuning of this illusion by manipulating the binocular disparities of the carrier and the envelope...
October 1, 2016: Journal of Vision
J R Griswold, D G Medvedev, J W Engle, R Copping, J M Fitzsimmons, V Radchenko, J C Cooley, M E Fassbender, D L Denton, K E Murphy, A C Owens, E R Birnbaum, K D John, F M Nortier, D W Stracener, L H Heilbronn, L F Mausner, S Mirzadeh
Actinium-225 and (213)Bi have been used successfully in targeted alpha therapy (TAT) in preclinical and clinical research. This paper is a continuation of research activities aiming to expand the availability of (225)Ac. The high-energy proton spallation reaction on natural thorium metal targets has been utilized to produce millicurie quantities of (225)Ac. The results of sixteen irradiation experiments of thorium metal at beam energies between 78 and 192MeV are summarized in this work. Irradiations have been conducted at Brookhaven National Laboratory (BNL) and Los Alamos National Laboratory (LANL), while target dissolution and processing was carried out at Oak Ridge National Laboratory (ORNL)...
September 28, 2016: Applied Radiation and Isotopes
Lionel Tortolano, Senda Hammami, Katia Manerlax, Bernard Do, Najet Yagoubi
Acrylic copolymers are useful in medical therapeutics. As in dental implants or intraocular lenses, acrylics are present in many medical devices or drug adjuvants. Industrial using of acrylics is still important in painting or textile manufacturing. Scientific research background has proved that acrylic suffer for depolymerized and cross-linking mechanisms under heating and photo-oxidative conditions. Those aging processes could lead to release of unreacted monomers and degradation products. We developed a new RP-HPLC method with good resolution, recovery, linearity, detection and quantification limits that is efficient for acrylic monomers quantification in in vitro and in vivo saline solution matrices...
October 18, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Gregory S Antonarakis, Bryan D Tompson, David M Fisher
OBJECTIVE:   Maxillary growth in patients with cleft lip and palate is highly variable. The authors' aim was to investigate associations between preoperative cleft lip measurements and maxillary growth determined cephalometrically in patients with complete unilateral cleft lip and palate (cUCLP). DESIGN:   Retrospective cross-sectional study. PATIENTS:   Children with cUCLP. METHODS:   Preoperative cleft lip measurements were made at the time of primary cheiloplasty and available for each patient...
November 2016: Cleft Palate-craniofacial Journal
Peter de Jonge, Annelieke M Roest, Carmen C W Lim, Silvia E Florescu, Evelyn J Bromet, Dan J Stein, Meredith Harris, Vladimir Nakov, Jose Miguel Caldas-de-Almeida, Daphna Levinson, Ali O Al-Hamzawi, Josep Maria Haro, Maria Carmen Viana, Guilherme Borges, Siobhan O'Neill, Giovanni de Girolamo, Koen Demyttenaere, Oye Gureje, Noboru Iwata, Sing Lee, Chiyi Hu, Aimee Karam, Jacek Moskalewicz, Viviane Kovess-Masfety, Fernando Navarro-Mateu, Mark Oakley Browne, Marina Piazza, José Posada-Villa, Yolanda Torres, Margreet L Ten Have, Ronald C Kessler, Kate M Scott
CONTEXT: The scarcity of cross-national reports and the changes in Diagnostic and Statistical Manual version 5 (DSM-5) regarding panic disorder (PD) and panic attacks (PAs) call for new epidemiological data on PD and PAs and its subtypes in the general population. OBJECTIVE: To present representative data about the cross-national epidemiology of PD and PAs in accordance with DSM-5 definitions. DESIGN AND SETTING: Nationally representative cross-sectional surveys using the World Health Organization Composite International Diagnostic Interview version 3...
October 24, 2016: Depression and Anxiety
Peter R Wiecha, Arnaud Arbouet, Christian Girard, Aurélie Lecestre, Guilhem Larrieu, Vincent Paillard
The rational design of photonic nanostructures consists of anticipating their optical response from systematic variations of simple models. This strategy, however, has limited success when multiple objectives are simultaneously targeted, because it requires demanding computational schemes. To this end, evolutionary algorithms can drive the morphology of a nano-object towards an optimum through several cycles of selection, mutation and cross-over, mimicking the process of natural selection. Here, we present a numerical technique that can allow the design of photonic nanostructures with optical properties optimized along several arbitrary objectives...
October 24, 2016: Nature Nanotechnology
Kelly D Moynihan, Cary F Opel, Gregory L Szeto, Alice Tzeng, Eric F Zhu, Jesse M Engreitz, Robert T Williams, Kavya Rakhra, Michael H Zhang, Adrienne M Rothschilds, Sudha Kumari, Ryan L Kelly, Byron H Kwan, Wuhbet Abraham, Kevin Hu, Naveen K Mehta, Monique J Kauke, Heikyung Suh, Jennifer R Cochran, Douglas A Lauffenburger, K Dane Wittrup, Darrell J Irvine
Checkpoint blockade with antibodies specific for cytotoxic T lymphocyte-associated protein (CTLA)-4 or programmed cell death 1 (PDCD1; also known as PD-1) elicits durable tumor regression in metastatic cancer, but these dramatic responses are confined to a minority of patients. This suboptimal outcome is probably due in part to the complex network of immunosuppressive pathways present in advanced tumors, which are unlikely to be overcome by intervention at a single signaling checkpoint. Here we describe a combination immunotherapy that recruits a variety of innate and adaptive immune cells to eliminate large tumor burdens in syngeneic tumor models and a genetically engineered mouse model of melanoma; to our knowledge tumors of this size have not previously been curable by treatments relying on endogenous immunity...
October 24, 2016: Nature Medicine
Verónica Rubio González, Susana Redondo Martín, Gema Ruíz López Del Prado, Mª Fe Muñoz Moreno, Alexander Velázquez Miranda
OBJECTIVE: Household Survey on Alcohol and Other Drugs shows the progressive increase in the consumption of hypnotics, alone or in combination with other substances. The aim of the research was to obtain information about the consumption of hypnotics and sedatives in population of Castilla y León treated in emergency medical services of four monitored hospitals between 2009-2013, describing clinical and epidemiological characteristics of the emergencies and what drugs were consumed, to provide information for future interventions...
October 24, 2016: Revista Española de Salud Pública
Daniele Giordan, Paolo Allasia, Niccolò Dematteis, Federico Dell'Anese, Marco Vagliasindi, Elena Motta
In this work, we present the results of a low-cost optical monitoring station designed for monitoring the kinematics of glaciers in an Alpine environment. We developed a complete hardware/software data acquisition and processing chain that automatically acquires, stores and co-registers images. The system was installed in September 2013 to monitor the evolution of the Planpincieux glacier, within the open-air laboratory of the Grandes Jorasses, Mont Blanc massif (NW Italy), and collected data with an hourly frequency...
October 21, 2016: Sensors
Dan Liu, Qisong Wang, Xin Liu, Ruixin Niu, Yan Zhang, Jinwei Sun
Accurately measuring the oil content and salt content of crude oil is very important for both estimating oil reserves and predicting the lifetime of an oil well. There are some problems with the current methods such as high cost, low precision, and difficulties in operation. To solve these problems, we present a multifunctional sensor, which applies, respectively, conductivity method and ultrasound method to measure the contents of oil, water, and salt. Based on cross sensitivity theory, these two transducers are ideally integrated for simplifying the structure...
October 21, 2016: Sensors
Alfred Chikweto, Ravindra N Sharma, Keshaw P Tiwari, Shiv K Verma, Rafael Calero-Bernal, Tiantian Jiang, Chunlei Su, Oliver C Kwok, Jitender P Dubey
The objectives of the present cross sectional study were to isolate and genotype Toxoplasma gondii in free-range chickens from Grenada, West Indies. Using the modified agglutination test, antibodies to T. gondii were found in 39 (26.9%) of 145 free-range chickens with titers of 25 in 7chickens; 50 in 6 chickens; 100 in 2 chickens; 200 or higher in 24 chickens. The hearts of the 39 seropositive chickens were bioassayed in mice; viable T. gondii was isolated from 20 and further propagated in cell culture. Genotyping of T...
October 24, 2016: Journal of Parasitology
S Cacanyiova, A Berenyiova, F Kristek
Cardiovascular studies have confirmed that hydrogen sulphide (H(2)S) is involved in various signaling pathways in both physiological and pathological conditions, including hypertension. In contrast to nitric oxide (NO), which has a clear vasorelaxant action, H(2)S has both vasorelaxing and vasoconstricting effects on the cardiovascular system. H(2)S is an important antihypertensive agent, and the reduced production of H(2)S and the alterations in its functions are involved in the initiation of spontaneous hypertension...
October 24, 2016: Physiological Research
Antonio Cataldo, Elisa Raffaella Ferrè, Giuseppe di Pellegrino, Patrick Haggard
When warm thermal stimulators are placed on the ring and index fingers of one hand, and a neutral-temperature stimulator on the middle finger, all three fingers feel warm. This illusion is known as thermal referral (TR). On one interpretation, the heterogenous thermal signals are overridden by homogenous tactile signals. This cross-modal thermo-tactile interaction could reflect a process of object recognition, based on the prior that many objects are thermally homogenous. Interestingly, the illusion was reported to disappear when the middle digit was lifted off the thermal stimulator, suggesting that tactile stimulation is necessary...
October 24, 2016: Scientific Reports
Meriem Attaf, Stephan J Holland, Istvan Bartok, Julian Dyson
αβ T cells respond to peptide epitopes presented by major histocompatibility complex (MHC) molecules. The role of T cell receptor (TCR) germline complementarity determining regions (CDR1 and 2) in MHC restriction is not well understood. Here, we examine T cell development, MHC restriction and antigen recognition where germline CDR loop structure has been modified by multiple glycine/alanine substitutions. Surprisingly, loss of germline structure increases TCR engagement with MHC ligands leading to excessive loss of immature thymocytes...
October 24, 2016: Scientific Reports
Ž L Jelić, M V Milošević, A V Silhanek
An experimental determination of the mean vortex velocity in superconductors mostly relies on the measurement of flux-flow resistance with magnetic field, temperature, or driving current. In the present work we introduce a method combining conventional transport measurements and a frequency-tuned flashing pinning potential to obtain reliable estimates of the vortex velocity. The proposed device is characterized using the time-dependent Ginzburg-Landau formalism, where the velocimetry method exploits the resonances in mean vortex dissipation when temporal commensuration occurs between the vortex crossings and the flashing potential...
October 24, 2016: Scientific Reports
Mineko Wada, William Bennett Mortenson, Laura Hurd Clarke
This study examined how relevant Rowe and Kahn's three criteria of successful aging were to older adults' self-portrayals in online dating profiles: low probability of disease and disability, high functioning, and active life engagement. In this cross-sectional study, 320 online dating profiles of older adults were randomly selected and coded based on the criteria. Logistic regression analyses determined whether age, gender, and race/ethnicity predicted self-presentation. Few profiles were indicative of successful aging due to the low prevalence of the first two criteria; the third criterion, however, was identified in many profiles...
October 24, 2016: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
Tamara Thomsen, Cathleen Kappes, Laura Schwerdt, Johanna Sander, Charlotte Poller
In two experiments, we investigated observational learning in social relationships as one possible pathway to the development of goal adjustment processes. In the first experiment, 56 children (M = 9.29 years) observed their parent as a model; in the second, 50 adults (M = 32.27 years) observed their romantic partner. Subjects were randomly assigned to three groups: goal engagement (GE), goal disengagement (GD), or control group (CO) and were asked to solve (unsolvable) puzzles. Before trying to solve the puzzles by themselves, subjects observed the instructed model, who was told to continue with the same puzzle (GE) or to switch to the next puzzle (GD)...
October 23, 2016: British Journal of Developmental Psychology
Amin Maghari
Melanocytic nevi, including dysplastic or atypical nevi (DN), can recur or persist following shave removal procedures, and recurrence may resemble melanoma, both clinically and histologically (pseudomelanoma). Recurrence may originate from proliferation of the remaining neoplastic melanocytes following incomplete removal. The present study determines the rate and etiology of this event. A cross-sectional analysis of 110 excision specimens showing histological recurrence was performed, and these specimens were compared to the slides of the original shave specimens showing mildly atypical DN...
2016: Dermatology Research and Practice
Camilla Kristoffersen, Rasmus B Jensen, Ekaterina Avershina, Dag Austbø, Anne-Helene Tauson, Knut Rudi
Knowledge on dynamic interactions in microbiota is pivotal for understanding the role of bacteria in the gut. We herein present comprehensive dynamic models of the horse cecal microbiota, which include short-chained fatty acids, carbohydrate metabolic networks, and taxonomy. Dynamic models were derived from time-series data in a crossover experiment in which four cecum-cannulated horses were fed a starch-rich diet of hay supplemented with barley (starch intake 2 g kg(-1) body weight per day) and a fiber-rich diet of only hay...
October 21, 2016: Microbes and Environments
Sophie Peeters, Caitlin Blaine, Iv Vycheth, Sam Nang, Din Vuthy, Kee B Park
BACKGROUND: Traumatic brain injury (TBI) is a critical public health problem worldwide with a significant socioeconomic burden. While improved safety regulations in high-income countries have resulted in a decline in traffic-related TBI, the incidence of TBI in low-income countries is on the rise. We illustrate the trends and factors involved in TBI in a large Cambodian governmental hospital in Phnom Penh. Additionally, suggestions for improvement of the country's road traffic safety are discussed...
October 20, 2016: World Neurosurgery
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