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Micro DNA carcinoma of the pancreas

Makoto Sunamura, Liviu P Lefter, Dan G Duda, Rina Morita, Hiroko Inoue, Tadaaki Yokoyama, Toshimasa Yatsuoka, Tadayoshi Abe, Shinichi Egawa, Toru Furukawa, Shinichi Fukushige, Mitsuo Oshimura, Akira Horii, Seiki Matsuno
To date, the events that mediate tumor progression in pancreatic cancer are still poorly understood. Cytogenetic, allelotype, and somatic cell hybrid studies in human pancreatic adenocarcinoma have suggested that chromosome 18 may carry tumor suppressor genes (TSGs), including SMAD4. We previously identified that LOH of 18q at the SMAD4 locus, along with LOHs on 17p and 12q, positively associated with poor prognoses of pancreatic cancer patients. However, restoration of the SMAD4 gene did not suppress in vitro proliferation of pancreatic cancer cells that harbored homozygous deletion of this gene...
April 2004: Pancreas
Maximilian Bockhorn, Yoshikazu Tsuzuki, Lei Xu, Andreja Frilling, Christoph E Broelsch, Dai Fukumura
PURPOSE: The objectives of this study were to investigate the effects of anti-vascular endothelial growth factor (VEGF) treatment on various vascular functions, gene expression, and growth of orthotopic human pancreatic cancer xenografts and thus to provide useful preclinical data for novel cancer treatments. EXPERIMENTAL DESIGN: Small pieces of a human pancreatic carcinoma, PANC-1, were implanted into the pancreas of male severe combined immunodeficient mice. The animals were treated with anti-human VEGF antibody A...
September 15, 2003: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
E E McGuinness, R G Morgan, K G Wormsley
The effect of trypsin inhibitor-containing diets was studied in rats, mice, and hamsters for 30 weeks. In rats, pancreatic weight, DNA, RNA, and protein increased in response to a diet of raw soya flour (containing trypsin inhibitor). In mice, pancreatic weight, DNA, RNA and protein content increased with the same diet. Only rats developed micro- and macro-nodules. In rats, longer treatment with raw soya flour resulted in further growth in the pancreas, with ultimate development of adenomas and carcinomas of the acinar pancreas...
1985: Scandinavian Journal of Gastroenterology. Supplement
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