keyword
MENU ▼
Read by QxMD icon Read
search

DCX

keyword
https://www.readbyqxmd.com/read/29663136/memory-retrieval-induced-activation-of-adult-born-neurons-generated-in-response-to-damage-to-the-dentate-gyrus
#1
Andrea Aguilar-Arredondo, Angélica Zepeda
The dentate gyrus (DG) is a neurogenic structure that exhibits functional and structural reorganization after injury. Neurogenesis and functional recovery occur after brain damage, and the possible relation between both processes is a matter of study. We explored whether neurogenesis and the activation of new neurons correlated with DG recovery over time. We induced a DG lesion in young adult rats through the intrahippocampal injection of kainic acid and analyzed functional recovery and the activation of new neurons after animals performed a contextual fear memory task (CFM) or a control spatial exploratory task...
April 16, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29625115/administration-of-placenta-derived-mesenchymal-stem-cells-counteracts-a-delayed-anergic-state-following-a-transient-induction-of-endogenous-neurogenesis-activity-after-global-cerebral-ischemia
#2
A Ra Kho, Ok Joon Kim, Jeong Hyun Jeong, Ji Min Yu, Hye Sun Kim, Bo Young Choi, Sang Won Suh, Tae Nyoung Chung
BACKGROUND: Global cerebral ischemia (GCI) is a major obstacle for cardiac arrest survival. Recent studies have suggested the possibility of mesenchymal stem cell (MSC) as a novel therapeutic option for GCI, but these results were limited to the neuroprotective effects of MSCs. Therefore, we aimed to investigate specific characteristics of neurogenesis after transient GCI, and to assess the effect of MSC on these characteristics. METHODS: Adult male Sprague-Dawley rats were subjected to 7 minutes of transient GCI and randomized into 7 groups: baseline, MSC, and control administered groups, to be analyzed at 2, 3, and 4 weeks after GCI, respectively...
April 3, 2018: Brain Research
https://www.readbyqxmd.com/read/29621303/time-dependent-regulation-of-morphological-changes-and-cartilage-differentiation-markers-in-the-mouse-pubic-symphysis-during-pregnancy-and-postpartum-recovery
#3
Bianca Gazieri Castelucci, Sílvio Roberto Consonni, Viviane Souza Rosa, Lucimara Aparecida Sensiate, Paula Cristina Rugno Delatti, Lúcia Elvira Alvares, Paulo Pinto Joazeiro
Animal models commonly serve as a bridge between in vitro experiments and clinical applications; however, few physiological processes in adult animals are sufficient to serve as proof-of-concept models for cartilage regeneration. Intriguingly, some rodents, such as young adult mice, undergo physiological connective tissue modifications to birth canal elements such as the pubic symphysis during pregnancy; therefore, we investigated whether the differential expression of cartilage differentiation markers is associated with cartilaginous tissue morphological modifications during these changes...
2018: PloS One
https://www.readbyqxmd.com/read/29614674/optical-depolarization-of-dcx-expressing-cells-promoted-cognitive-recovery-and-maturation-of-newborn-neurons-via-the-wnt-%C3%AE-catenin-pathway
#4
Ming-Liang Zhao, Shi-Jin Chen, Xiao-Hong Li, Li-Na Wang, Feng Chen, Shi-Jiang Zhong, Cheng Yang, Sheng-Kai Sun, Jian-Jun Li, Hua-Jiang Dong, Yue-Qing Dong, Yi Wang, Chong Chen
Electrical excitability by membrane depolarization is crucial for survival and maturation of newborn cells in the dentate gyrus of the hippocampus. However, traditional technology for membrane depolarization lacks temporal and spatial precision. Optogenetics can be used to activate channelrhodopsin-2 (ChR2), allowing cationic current to depolarize genetically targeted cells. In this study, we used ChR2-EGFP driven by doublecortin (DCX) to promote survival and maturation of newborn cells in the dentate gyrus after traumatic brain injury (TBI)...
March 28, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29610167/-hla-a-31-01-and-oxcarbazepine-induced-dress-in-a-patient-with-seizures-and-complete-dcx-deletion
#5
Hyun Kim, Laura Chadwick, Yasir Alzaidi, Jonathan Picker, Annapurna Poduri, Shannon Manzi
Oxcarbazepine is an antiepileptic drug (AED) commonly used as a first-line treatment option for focal epilepsy. Several AEDs, including carbamazepine, oxcarbazepine, and phenytoin are associated with various delayed-hypersensitivity reactions such as drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome, or toxic epidermal necrolysis. The Food and Drug Administration-approved label for oxcarbazepine currently presents information regarding a pharmacogenomic association with the HLA antigen allele HLA-B*15:02 and hypersensitivity reactions in certain ancestry groups with a high incidence of this allele...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29578075/the-effects-of-maternal-diabetes-and-insulin-treatment-on-neurogenesis-in-the-developing-hippocampus-of-male-rats
#6
Akram Sadeghi, Ebrahim Esfandiary, Javad Hami, Hossein Khanahmad, Zahra Hejazi, Mohammad Mardani, Shahnaz Razavi
Diabetes in pregnancy is associated with an increasing risk of congenital malformations and central nervous system disorders (CNS) especially hippocampal neuronal circuitry disruption as a discreet region involved in neurogenesis phenomenon. This study aimed to investigate the effect of maternal diabetes and insulin treatment on the expression and distribution pattern of NeuN and DCX as two important markers of neurogenesis paradigm in developing rat hippocampus. All animals were randomly divided into three groups as follows: Control group, Diabetic (STZ-D), Diabetic treated with insulin (STZ-INS)...
March 22, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29571823/dexmedetomidine-promotes-the-recovery-of-neurogenesis-in-aged-mouse-with-postoperative-cognitive-dysfunction
#7
Wen-Xiang Wang, Qiong Wu, Si-Si Liang, Xue-Kang Zhang, Qian Hu, Qiu-Hong Chen, Hai-Jin Huang, Lin Xu, Fo-Quan Lou
Recently, growing evidence has demonstrated Dexmedetomidine (Dex) a promising intervene preventing postoperative cognitive decline (POCD) following surgery, which is associated with neuroinflammation leading to neuronal apoptosis and deregulated neurogenesis. Previous studies suggested the anti-inflammation and anti-neuroapoptosis action of Dex. Therefore we hypothesize the promoting neurogenesis of Dex linked to stimulating BDNF and subsequent p-MPAK production in a rat model of POCD. In the present study, the POCD animal model was established by performing an exploratory laparotomy under isoflurane anaesthesia in old rats, utilizing which Dex response is confirmed by behavioural tests...
March 20, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29560627/-effect-of-moxibustion-on-delayed-memory-and-expression-of-hippocampal-nestin-and-doublecortin-proteins-in-dementia-rats
#8
Yin-Qiu Fan, Jing-Cheng Cui, Jun Yang, Pin Wang
OBJECTIVE: To observe the effect of "Huayu Tongluo"(Blood-stasis Dispersing and Meridian-collateral Dredging) moxibustion on the delayed memory and expression of Nestin and Doublecortin (DCX) proteins in the hippocampus in vascular dementia (VD) rats in the view of neurogenesis produced by intracerebral transplantation of neural stem cells (NSCs) and endothelial progenitor cells (EPCs). METHODS: Healthy male Wistar rats were randomized into control group, VD model group,NSCs+EPCs group and NSCs+EPCs moxibustion group...
March 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29554741/elimination-of-isoxazolyl-penicillins-antibiotics-in-waters-by-the-ligninolytic-native-colombian-strain-leptosphaerulina-sp-considerations-on-biodegradation-process-and-antimicrobial-activity-removal
#9
Ledys S Copete-Pertuz, Jersson Plácido, Efraím A Serna-Galvis, Ricardo A Torres-Palma, Amanda Mora
In this work, Leptosphaerulina sp. (a Colombian native fungus) significantly removed three Isoxazolyl-Penicillin antibiotics (IP): oxacillin (OXA, 16000 μg L-1 ), cloxacillin (CLX, 17500 μg L-1 ) and dicloxacillin (DCX, 19000 μg L-1 ) from water. The biological treatment was performed at pH 5.6, 28 °C, and 160 rpm for 15 days. The biotransformation process and lack of toxicity of the final solutions (antibacterial activity (AA) and cytotoxicity) were tested. The role of enzymes in IP removal was analysed through in vitro studies with enzymatic extracts (crude and pre-purified) from Leptosphaerulina sp...
March 2, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29548728/rufinamide-an-antiepileptic-drug-improves-cognition-and-increases-neurogenesis-in-the-aged-gerbil-hippocampal-dentate-gyrus-via-increasing-expressions-of-igf-1-igf-1r-and-p-creb
#10
Bai Hui Chen, Ji Hyeon Ahn, Joon Ha Park, Minah Song, Hyunjung Kim, Tae-Kyeong Lee, Jae Chul Lee, Young-Myeong Kim, In Koo Hwang, Dae Won Kim, Choong-Hyun Lee, Bing Chun Yan, Il Jun Kang, Moo-Ho Won
Rufinamide is a novel antiepileptic drug and commonly used in the treatment of Lennox-Gastaut syndrome. In the present study, we investigated effects of rufinamide on cognitive function using passive avoidance test and neurogenesis in the hippocampal dentate gyrus using Ki-67 (a marker for cell proliferation), doublecortin (DCX, a marker for neuroblast) and BrdU/NeuN (markers for newly generated mature neurons) immunohistochemistry in aged gerbils. Aged gerbils (24-month old) were treated with 1 mg/kg and 3 mg/kg rufinamide for 4 weeks...
March 13, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29521292/-glehnia-littoralis-extract-promotes-neurogenesis-in-the-hippocampal-dentate-gyrus-of-the-adult-mouse-through-increasing-expressions-of-brain-derived-neurotrophic-factor-and-tropomyosin-related-kinase-b
#11
Joon Ha Park, Bich Na Shin, Ji Hyeon Ahn, Jeong Hwi Cho, Tae-Kyeong Lee, Jae-Chul Lee, Yong Hwan Jeon, Il Jun Kang, Ki-Yeon Yoo, In Koo Hwang, Choong Hyun Lee, Yoo Hun Noh, Sung-Su Kim, Moo-Ho Won, Jong Dai Kim
Background: Glehnia littoralis has been used for traditional Asian medicine, which has diverse therapeutic activities. However, studies regarding neurogenic effects of G. littoralis have not yet been considered. Therefore, in this study, we examined effects of G. littoralis extract on cell proliferation, neuroblast differentiation, and the maturation of newborn neurons in the hippocampus of adult mice. Methods: A total of 39 male ICR mice (12 weeks old) were randomly assigned to vehicle-treated and 100 and 200 mg/kg G...
March 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29520167/toll-like-receptor-2-promotes-neurogenesis-from-the-dentate-gyrus-after-photothrombotic-cerebral-ischemia-in-mice
#12
Kyung-Joo Seong, Hyeong-Jun Kim, Bangrong Cai, Min-Suk Kook, Ji-Yeon Jung, Won-Jae Kim
The subgranular zone (SGZ) of hippocampal dentate gyrus (HDG) is a primary site of adult neurogenesis. Toll-like receptors (TLRs), are involved in neural system development of Drosophila and innate immune response of mammals. TLR2 is expressed abundantly in neurogenic niches such as adult mammalian hippocampus. It regulates adult hippocampal neurogenesis. However, the role of TLR2 in adult neurogenesis is not well studied in global or focal cerebral ischemia. Therefore, this study aimed to investigate the role of TLR2 in adult neurogenesis after photochemically induced cerebral ischemia...
March 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29512704/intravenous-administration-of-dpscs-and-bdnf-improves-neurological-performance-in-rats-with-focal-cerebral-ischemia
#13
Xuemei Zhang, Yinglian Zhou, Hulun Li, Rui Wang, Dan Yang, Bing Li, Jin Fu
Dental pulp stem cells (DPSCs) are considered as an ideal stem cell source for the treatment of neurological diseases. In this study, we evaluated the therapeutic potency of DPSCs and brain-derived neurotrophic factor (BDNF) in focal cerebral ischemia using animal models. Following middle cerebral artery occlusion (MCAO), rats were randomized into four groups: the BDNF, DPSCs, DPSCs+BDNF and the controls injected with saline. DPSCs were transplanted and BDNF was injected into the DPSCs+BDNF group via the tail vein...
February 28, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29512697/ephrin%C3%A2-b3-modulates-hippocampal-neurogenesis-and-the-reelin-signaling-pathway-in-a-pilocarpine%C3%A2-induced-model-of-epilepsy
#14
Tian-Tian Liu, Yi Li, Yi Shu, Bo Xiao, Li Feng
Ephrin‑B3 is important in the regulation of cell proliferation, differentiation and migration via cell‑cell contact, and can activate the reelin pathway during brain development. However, the effect of ephrin‑B3 on hippocampal neurogenesis and the reelin pathway in epilepsy remains to be fully elucidated. In the present study, the expression of ephrin‑B3 in pilocarpine‑induced status epilepticus (SE) rats was investigated. SYBR Green‑based reverse transcription‑quantitative polymerase chain reaction analysis, immunohistochemical labeling and western blot analysis were used to detect the gene and protein expression levels of ephrin‑B3 and reelin pathway proteins...
March 7, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29487507/putative-adult-neurogenesis-in-old-world-parrots-the-congo-african-grey-parrot-psittacus-erithacus-and-timneh-grey-parrot-psittacus-timneh
#15
Pedzisai Mazengenya, Adhil Bhagwandin, Paul R Manger, Amadi O Ihunwo
In the current study, we examined for the first time, the potential for adult neurogenesis throughout the brain of the Congo African grey parrot ( Psittacus erithacus ) and Timneh grey parrot ( Psittacus timneh ) using immunohistochemistry for the endogenous markers proliferating cell nuclear antigen (PCNA), which labels proliferating cells, and doublecortin (DCX), which stains immature and migrating neurons. A similar distribution of PCNA and DCX immunoreactivity was found throughout the brain of the Congo African grey and Timneh grey parrots, but minor differences were also observed...
2018: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29486219/environmentally-relevant-manganese-overexposure-alters-neural-cell-morphology-and-differentiation-in-vitro
#16
Amy B Parsons-White, Nadja Spitzer
Manganese (Mn) is a trace metal and micronutrient that is necessary for neurological function. Because of its ability to cross the blood brain barrier, excessive amounts of Mn are neurotoxic and can lead to a neurological disorder, manganism. Environmental overexposure to Mn correlates with impaired cognitive development in children. Though symptoms of manganism and overexposure are well defined, the changes in cellular mechanisms underlying these symptoms are not fully understood. We used cultured adult neural stem cells (NSCs) from young adult rats as an accessible model to investigate the effect of Mn on cellular mechanisms underlying neural differentiation...
February 24, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29471869/type-2-diabetes-impairs-odour-detection-olfactory-memory-and-olfactory-neuroplasticity-effects-partly-reversed-by-the-dpp-4-inhibitor-linagliptin
#17
Grazyna Lietzau, William Davidsson, Claes-Göran Östenson, Fausto Chiazza, David Nathanson, Hiranya Pintana, Josefin Skogsberg, Thomas Klein, Thomas Nyström, Vladimer Darsalia, Cesare Patrone
Recent data suggest that olfactory deficits could represent an early marker and a pathogenic mechanism at the basis of cognitive decline in type 2 diabetes (T2D). However, research is needed to further characterize olfactory deficits in diabetes, their relation to cognitive decline and underlying mechanisms.The aim of this study was to determine whether T2D impairs odour detection, olfactory memory as well as neuroplasticity in two major brain areas responsible for olfaction and odour coding: the main olfactory bulb (MOB) and the piriform cortex (PC), respectively...
February 23, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29451906/brain-changes-due-to-hypoxia-during-light-anaesthesia-can-be-prevented-by-deepening-anaesthesia-a-study-in-rats
#18
Setayesh R Tasbihgou, Mina Netkova, Alain F Kalmar, Janine Doorduin, Michel M R F Struys, Regien G Schoemaker, Anthony R Absalom
In anaesthetic practice the risk of cerebral ischemic/hypoxic damage is thought to be attenuated by deep anaesthesia. The rationale is that deeper anaesthesia reduces cerebral oxygen demand more than light anaesthesia, thereby increasing the tolerance to ischemia or hypoxia. However, evidence to support this is scarce. We thus investigated the influence of light versus deep anaesthesia on the responses of rat brains to a period of hypoxia. In the first experiment we exposed adult male Wistar rats to deep or light propofol anaesthesia and then performed [18F]- Fludeoxyglucose (FDG) Positron Emission Tomography (PET) scans to verify the extent of cerebral metabolic suppression...
2018: PloS One
https://www.readbyqxmd.com/read/29449593/hemopexin-is-required-for-adult-neurogenesis-in-the-subventricular-zone-olfactory-bulb-pathway
#19
Yanling Zhu, Yang Qiu, Mengjia Chen, Yi Zhang, Li Cao, Zhida Su, Yimin Yuan, Aijun Huang, Yinyan Pu, Cheng He
The neural stem cells (NSCs) of the subventricular zone (SVZ) reside within a specialized niche critical for neurogenesis. Hemopexin, a plasma glycoprotein, has been extensively studied as a heme scavenger at the systemic level. However, little is known about its function in the central nervous system, especially in neurogenesis. In the present study, we demonstrate that deletion of hemopexin leads to neurogenic abnormalities in the SVZ/olfactory bulb (OB) pathway. The lateral ventricle is enlarged in hemopexin-deficient mice, and more apoptosis was observed in Dcx+ cells...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29417597/acute-ethanol-inhibition-of-adult-hippocampal-neurogenesis-involves-cb1-cannabinoid-receptor-signaling
#20
Dal Khatri, Genevieve Laroche, Marion L Grant, Victoria M Jones, Ryan P Vetreno, Fulton T Crews, Somnath Mukhopadhyay
BACKGROUND: Chronic ethanol exposure has been found to inhibit adult hippocampal neurogenesis in multiple models of alcohol addiction. However, acute ethanol inhibition of adult neurogenesis is not well studied. Although many abused drugs have been found to inhibit adult neurogenesis, few have studied cannabinoids or cannabinoids with ethanol, although human use of both together is becoming more common. We used an acute binge alcohol drinking model in combination with select cannabinoid receptor agonists and antagonists to investigate the actions of each alone and together on hippocampal neurogenesis...
February 8, 2018: Alcoholism, Clinical and Experimental Research
keyword
keyword
32717
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"