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Cassandra B Jabara, Fengyu Hu, Katie R Mollan, Sara E Williford, Prema Menezes, Yan Yang, Joseph J Eron, Michael W Fried, Michael G Hudgens, Corbin D Jones, Ronald Swanstrom, Stanley M Lemon
HIV coinfection accelerates disease progression in chronic hepatitis C and reduces sustained antiviral responses (SVR) to interferon-based therapy. New direct-acting antivirals (DAAs) promise higher SVR rates, but the selection of preexisting resistance-associated variants (RAVs) may lead to virologic breakthrough or relapse. Thus, pretreatment frequencies of RAVs are likely determinants of treatment outcome but typically are below levels at which the viral sequence can be accurately resolved. Moreover, it is not known how HIV coinfection influences RAV frequency...
October 2014: Antimicrobial Agents and Chemotherapy
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