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https://www.readbyqxmd.com/read/28646794/dexibuprofen-prevents-neurodegeneration-and-cognitive-decline-in-appswe-ps1de9-through-multiple-signaling-pathways
#1
Miren Ettcheto, Elena Sánchez-López, Laura Pons, Oriol Busquets, Jordi Olloquequi, Carlos Beas-Zarate, Merce Pallas, Maria Luisa García, Carme Auladell, Jaume Folch, Antoni Camins
The aim of the present study is to elucidate the neuronal pathways associated to NSAIDs causing a reduction of the risk and progression of Alzheimer's disease. The research was developed administering the active enantiomer of ibuprofen, dexibuprofen (DXI), in order to reduce associated gastric toxicity. DXI was administered from three to six-month-old female APPswe/PS1dE9 mice as a model of familial Alzheimer's disease. DXI treatment reduced the activation of glial cells and the cytokine release involved in the neurodegenerative process, especially TNFα...
June 15, 2017: Redox Biology
https://www.readbyqxmd.com/read/28645869/real-time-changes-in-brain-activity-during-sacral-neuromodulation-for-overactive-bladder
#2
Bradley C Gill, Javier Pizarro Berdichevsky, Pallab K Bhattacharyya, Thaddeus S Brink, Brian K Marks, Adrienne Quirouet, Sandip P Vasavada, Stephen E Jones, Howard B Goldman
PURPOSE: To use functional magnetic resonance imaging(fMRI) for identifying changes in brain activity during sacral neuromodulation(SNM) in women with overactive bladder(OAB) who were responsive to therapy. MATERIALS AND METHODS: Women with non-neurogenic refractory OAB who responded to SNM, had a stable program for at least 3 months, with no subsequent OAB treatment were recruited. Enrolled patients completed pre-fMRI validated symptom and quality of life instruments...
June 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28645478/a-tspo-ligand-prevents-mitochondrial-sterol-accumulation-and-dysfunction-during-myocardial-ischemia-reperfusion-in-hypercholesterolemic-rats
#3
Julien Musman, Stéphanie Paradis, Mathieu Panel, Sandrine Pons, Caroline Barau, Claudio Caccia, Valerio Leoni, Bijan Ghaleh, Didier Morin
A major cause of cell death during myocardial ischemia-reperfusion is mitochondrial dysfunction. We previously showed that the reperfusion of an ischemic myocardium was associated with an accumulation of cholesterol into mitochondria and a concomitant strong generation of auto-oxidized oxysterols. The inhibition of mitochondrial accumulation of cholesterol abolished the formation of oxysterols and prevented mitochondrial injury at reperfusion. The aim of this study was to investigate the impact of hypercholesterolemia on sterol and oxysterol accumulation in rat cardiac cytosols and mitochondria and to analyse the effect of the translocator protein ligand 4'-chlorodiazepam on this accumulation and mitochondrial function...
June 20, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28645434/is-there-room-for-theophylline-in-copd
#4
Núria Toledo-Pons, Borja G Cosío
No abstract text is available yet for this article.
June 20, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28644542/the-conservation-significance-of-natural-hybridisation-in-mediterranean-plants-from-a-case-study-on-cyclamen-primulaceae-to-a-general-perspective
#5
John D Thompson, Perrine Gauthier, Guillaume Papuga, Virginie Pons, Max Debussche, Emmanuele Farris
Hybridisation plays a prominent role in plant evolution due to its influence on genetic diversity, fitness and adaptive potential We identify a case of on-going hybrid evolution of floral phenotypes in disjunct populations of Cyclamen balearicum and C. repandum subsp. repandum on Corsica and Sardinia. Hybrid populations on the two islands contain similar patterns of variation in flower colour and size but are probably at different stages in the evolutionary process of hybridisation and differences in the frequency of floral types and flower size suggest hybrid vigour that may contribute to the dynamics and maintenance of hybrid forms...
June 23, 2017: Plant Biology
https://www.readbyqxmd.com/read/28642266/t1-signal-measurements-in-pediatric-brain-findings-after-multiple-exposures-to-gadobenate-dimeglumine-for-imaging-of-nonneurologic-disease
#6
G K Schneider, J Stroeder, G Roditi, C Colosimo, P Armstrong, M Martucci, A Buecker, P Raczeck
BACKGROUND AND PURPOSE: Signal intensity increases possibly suggestive of gadolinium retention have recently been reported on unenhanced T1-weighted images of the pediatric brain following multiple exposures to gadolinium-based MR contrast agents. Our aim was to determine whether T1 signal changes suggestive of gadolinium deposition occur in the brains of pediatric nonneurologic patients after multiple exposures to gadobenate dimeglumine. MATERIALS AND METHODS: Thirty-four nonneurologic patients (group 1; 17 males/17 females; mean age, 7...
June 22, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28642018/clinical-study-of-27-patients-with-medial-medullary-infarction
#7
Takayoshi Akimoto, Katsuhiko Ogawa, Akihiko Morita, Yutaka Suzuki, Satoshi Kamei
BACKGROUND: Medial medullary infarction (MMI) is a rare ischemic stroke. Frequency of each neurological finding in MMI was different in each study. METHODS: We retrospectively evaluated the medical records of patients with cerebral infarction who were admitted between March 1998 and October 2015. Patients in our study were diagnosed as having MMI by magnetic resonance image examination. RESULTS: Of 2727 patients with ischemic stroke, 27 patients (20 males and 7 females) had MMI...
June 20, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28641987/food-deprivation-in-f0-generation-and-hypercaloric-diet-in-f1-generation-reduce-f2-generation-astrogliosis-in-several-brain-areas-after-immune-challenge
#8
T B Ogassawara, A Joaquim, C P Coelho, M M Bernardi, E Teodorov, M F M Martins, T B Kirsten, L V Bonamin, P D Dossa, L B Viebig, E F Bondan
AIMS: The effects of maternal food restriction during gestation in F0 generation followed by hypercaloric diet (HD) during puberty in F1 generation (F1HD) were investigated on astrocyte behavior of F2 generation. Also, the astrocyte behavior, after an immune challenge, was examined by the immunohistochemical expression of glial fibrillary acidic protein (GFAP) in several brain areas. METHODS: The body weight gain (BW) during development and in postnatal day (PND) 90-95, the retroperitoneal fat weight (RPF), and the size of larger and smaller adipocytes in the F1 generation were assessed to observe the effects of HD in female rats...
June 19, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28641894/carbon-assimilation-and-losses-during-an-ocean-acidification-mesocosm-experiment-with-special-reference-to-algal-blooms
#9
Nana Liu, Shanying Tong, Xiangqi Yi, Yan Li, Zhenzhen Li, Hangbin Miao, Tifeng Wang, Futian Li, Dong Yan, Ruiping Huang, Yaping Wu, David A Hutchins, John Beardall, Minhan Dai, Kunshan Gao
A mesocosm experiment was conducted in Wuyuan Bay (Xiamen), China, to investigate the effects of elevated pCO2 on bloom formation by phytoplankton species previously studied in laboratory-based ocean acidification experiments, to determine if the indoor-grown species performed similarly in mesocosms under more realistic environmental conditions. We measured biomass, primary productivity and particulate organic carbon (POC) as well as particulate organic nitrogen (PON). Phaeodactylum tricornutum outcompeted Thalassiosira weissflogii and Emiliania huxleyi, comprising more than 99% of the final biomass...
May 27, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28641180/potential-chemotherapeutic-effects-of-diosgenin-zoledronic-acid-and-epigallocatechin-3-gallate-on-pe-ca-pj15-oral-squamous-cancer-cell-line
#10
Eduardo Pons-Fuster López, Qin-Tong Wang, Wei Wei, Pia López Jornet
OBJECTIVE: To study the potential chemotherapeutic effects of Diosgenin, zoledronic acid and Epigallocatechin-3-gallate on oral squamous cell cancer (OSCC). MATERIALS AND METHODS: Cell viability, migration, apoptosis and cell cycle evaluation assays were performed in order to assess the effects of different doses of Diosgenin, zoledronic acid and Epigallocatechin-3-gallate on the PE/CA-PJ15 cell line. RESULTS: Doses of 100μM of diosgenin or zoledronic acid reduced cell viability significantly after 72h (p<0...
June 19, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28640695/gadolinium-brain-deposition-after-macrocyclic-gadolinium-administration-a-pediatric-case-control-study
#11
Daniel Tibussek, Christin Rademacher, Julian Caspers, Bernd Turowski, Jörg Schaper, Gerald Antoch, Dirk Klee
Purpose To determine whether signal intensity (SI) in T1 sequences as a potential indicator of gadolinium deposition increases after repeated administration of the macrocyclic gadolinium-based contrast agents (GBCAs) gadoteridol and gadoterate meglumine in a pediatric cohort. Materials and Methods This retrospective case-control study of children with brain tumors who underwent nine or more contrast material-enhanced brain magnetic resonance (MR) imaging studies from 2008 to 2015 was approved by the local ethics board...
June 21, 2017: Radiology
https://www.readbyqxmd.com/read/28637935/a-case-of-chronic-lymphocytic-inflammation-with-pontine-perivascular-enhancement-responsive-to-steroids-clippers-with-the-largest-lesion-in-the-temporal-lobe
#12
Hiraku Matsuura, Naoki Makita, Ryotaro Ishii, Yasuko Fujita, Yuichi Furuno, Toshiki Mizuno
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disease of the central nervous system with a predilection for the hindbrain. Generally, lesions decrease in size with increasing distance from the hindbrain. We herein describe a case of CLIPPERS in a patient showing the largest lesions in the temporal lobe. A 49-year-old man consulted to our hospital with a 22-day history of a high fever and an abnormal visual field involving the left eye...
June 21, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28636186/views-of-general-practice-staff-about-the-use-of-a-patient-oriented-treatment-decision-aid-in-shared-decision-making-for-patients-with-type-2-diabetes-a-mixed-methods-study
#13
Anita Wildeboer, Esther du Pon, Jan Schuling, Flora M Haaijer-Ruskamp, Petra Denig
BACKGROUND: Decision aids can be used to support shared decision making (SDM). A patient-oriented treatment decision aid (DA) was developed for type 2 diabetes but its use by general practice staff appeared to be limited. OBJECTIVES: To explore views of practice staff towards SDM and the DA. DESIGN: A mixed-methods study within the Dutch PORTDA-diab trial. SETTING AND PARTICIPANTS: Included were 17 practices with staff members who were responsible for routine diabetes care and had worked with the DA, and 209 of their patients...
June 21, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28631142/parametric-imaging-of-11-c-flumazenil-binding-in-the-rat-brain
#14
Isadora Lopes Alves, David Vállez Vállez García, Andrea Parente, Janine Doorduin, Ana Maria Marques da Silva, Michel Koole, Rudi Dierckx, Antoon Willemsen, Ronald Boellaard
PURPOSE: This study evaluates the performance of several parametric methods for assessing [(11)C]flumazenil binding distribution in the rat brain. PROCEDURES: Dynamic (60 min) positron emission tomography data with metabolite-corrected plasma input function were retrospectively analyzed (male Wistar rats, n = 10). Distribution volume (V T) images were generated from basis function method (BFM), Logan graphical analysis (Logan), and spectral analysis (SA). Using the pons as pseudo-reference tissue, binding potential (BP ND and DVR-1) images were obtained from receptor parametric imaging algorithms (RPM and SRTM2) and reference Logan (RLogan)...
June 19, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28629563/positron-emission-tomography-computed-tomography-in-patients-with-hepatocellular-carcinoma-undergoing-liver-transplantation-useful-necessary-or-irrelevant
#15
REVIEW
Pedro Antonio Cascales-Campos, Pablo Ramírez Romero, Marcel André Schneider, Victor Lopez-Lopez, José Luis Navarro, Laura Frutos, Jose Antonio Pons Miñano, Pascual Parrilla Paricio
Hepatocellular Carcinoma (HCC) is an aggressive tumor entity, with the only curative options being surgical resection or orthotopic liver transplantation (OLT). The presence of one single tumor nodule of less than 5 centimeters diameter or a maximum of 3 nodules, with the largest of these not exceeding 3 centimeters (Milan criteria) constitute the clinical situation in which the best results for OLT in patients with HCC have been achieved. The survival of patients fulfilling the Milan criteria after transplantation is comparable to patients with similar tumor stages without cirrhosis, undergoing hepatic resection...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28628613/immunosuppressive-and-angiogenic-cytokine-profile-associated-with-bartonella-bacilliformis-infection-in-post-outbreak-and-endemic-areas-of-carrion-s-disease-in-peru
#16
Maria J Pons, Cláudia Gomes, Ruth Aguilar, Diana Barrios, Miguel Angel Aguilar-Luis, Joaquim Ruiz, Carlota Dobaño, Juana Del Valle-Mendoza, Gemma Moncunill
Analysis of immune responses in Bartonella bacilliformis carriers are needed to understand acquisition of immunity to Carrion's disease and may allow identifying biomarkers associated with bacterial infection and disease phases. Serum samples from 144 healthy subjects from 5 villages in the North of Peru collected in 2014 were analyzed. Four villages had a Carrion's disease outbreak in 2013, and the other is a traditionally endemic area. Thirty cytokines, chemokines and growth factors were determined in sera by fluorescent bead-based quantitative suspension array technology, and analyzed in relation to available data on bacteremia quantified by RT-PCR, and IgM and IgG levels measured by ELISA against B...
June 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28626626/television-viewing-time-among-statin-users-and-non-users-the-polish-norwegian-study-pons
#17
Georgeta D Vaidean, Sandeep S Vansal, Marta Manczuk
Sedentary behavior has emerged as an independent cardiovascular disease risk factor. Uncertainty exists about the behaviors of statin users, who may exhibit either a healthy adherer or a false reassurance effect. We conducted this study in order to assess and compare TV viewing among statin users and nonusers. We used data from a cross-sectional study of 12,754 participants, from south-east Poland, age 45 to 64 years in 2010-11. Statin use during last 30 days was recorded by trained nurses. Participants reported time spent viewing TV/week...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28623707/the-role-of-pon-1-gr-il-18-and-oxldl-in-depression-with-and-without-posttraumatic-stress-disorder
#18
Ewa A Ogłodek
BACKGROUND: Both oxidative stress markers and inflammatory markers are important when diagnosing depression. Oxidative stress occurs due to an imbalance between free radical generation and antioxidant potential. Both adenosine triphosphate and reactive oxygen/nitrogen species are released during oxidative phosphorylation. When neuroinflammation and free radical production are increased, oxidative stress occurs and causes damage to all major cellular macromolecules. The aim of the study was to compare the concentrations of paraoxonase-1 (PON-1), glutathione reductase (GR), interleukin-18 (IL-18), and oxidized low-density lipoproteins (OxLDL) in depressed patients with and without posttraumatic stress disorder (PTSD), and PTSD alone...
March 27, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28620261/single-nucleotide-polymorphism-based-genetic-diversity-analysis-of-the-kilakarsal-and-vembur-sheep-breeds
#19
Rathinasamy Selvam, Nagarajan Murali, A Kannan Thiruvenkadan, Ramesh Saravanakumar, Gurusamy Ponnudurai, Thilak Pon Jawahar
AIM: The present study was thus undertaken to analyze the genetic diversity of Kilakarsal and Vembur sheep breeds using single-nucleotide polymorphism (SNP) markers within Toll-like receptor (TLR) 3, 5, 6, 9, and 10 genes. MATERIALS AND METHODS: Competitive allele-specific polymerase chain reaction (PCR)-based end-point genotyping was performed using real-time PCR to type the SNPs. Allele discrimination module implemented in real-time PCR was utilized to call the genotypes based on fluorescence intensity recorded for each of the two alleles...
May 2017: Veterinary World
https://www.readbyqxmd.com/read/28619845/the-prohibitin-binding-compound-fluorizoline-induces-apoptosis-in-chronic-lymphocytic-leukemia-cells-through-the-upregulation-of-noxa-and-synergizes-with-ibrutinib-aicar-or-venetoclax
#20
Ana M Cosialls, Helena Pomares, Daniel Iglesias-Serret, José Saura-Esteller, Sonia Núñez-Vázquez, Diana M González-Gironès, Esmeralda de la Banda, Sara Preciado, Fernando Albericio, Rodolfo Lavilla, Gabriel Pons, Eva M González-Barca, Joan Gil
Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In this study, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia. Fluorizoline induced apoptosis in chronic lymphocytic leukemia cells at concentrations in the low micromolar range. All primary samples were sensitive to fluorizoline irrespectively of patients' clinical or genetic features, whereas normal T lymphocytes were less sensitive...
June 15, 2017: Haematologica
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