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K Rajkumar, P Mukhopadhyay, Ramen Sinha
PURPOSE: The study assessed the efficacy of orthopedic suture anchor as a modified suture anchor for disc repositioning in case of a closed lock of TMJ. PATIENT AND METHODS: Disc repositioning was undertaken via a mini preauricular approach. The disc was repositioned on the surface of the condyle and stabilized using an orthopedic suture anchor. Postoperatively functional outcomes were assessed in terms of reduction in pain, joint movement and absence of joint noise and clicking sounds...
September 2016: Journal of Maxillofacial and Oral Surgery
Bhaskar Sen, Sanjoy Kumar Sheet, Romita Thounaojam, Ramen Jamatia, Amarta Kumar Pal, Kripamoy Aguan, Snehadrinarayan Khatua
A new coumarin based Schiff base compound, CSB-1 has been synthesized to detect metal ion based on the chelation enhanced fluorescence (CHEF). The cation binding properties of CSB-1 was thoroughly examined in UV-vis and fluorescence spectroscopy. In fluorescence spectroscopy the compound showed high selectivity toward Al(3+) ion and the Al(3+) can be quantified in mixed aqueous buffer solution (MeOH: 0.01M HEPES Buffer; 9:1; v/v) at pH7.4 as well as in BSA media. The fluorescence intensity of CSB-1 was enhanced by ~24 fold after addition of only five equivalents of Al(3+)...
October 11, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Jee-Young Yeon, Soon-Kyu Lee
BACKGROUND/OBJECTIVES: The aim of this study was to investigate the perception of sugar reduction, nutrition education, and frequency of snacking in children according to the self-perceived dietary preferences for sweet taste by mothers in Busan. SUBJECTS/METHODS: A total of 277 mothers were surveyed, and their perceptions of sugar reduction and the frequency of snacking in children were assessed using a questionnaire. The subjects were classified into either a sweet (n = 91) or an unsweet (n = 186) group according to their self-perceived preferences for a sweet taste...
October 2016: Nutrition Research and Practice
Ramen H Chmait, Eftichia V Kontopoulos, Andrew H Chon, Lisa M Korst, Arlyn Llanes, Rubén A Quintero
OBJECTIVES: Amniopatch is a proposed treatment of iatrogenic preterm premature rupture of membranes (iPPROM). We studied characteristics associated with successful amniopatch treatment of iPPROM after fetoscopic laser surgery for twin-twin transfusion syndrome. METHODS: Patients with iPPROM within 15 days of laser surgery treated with an amniopatch were studied. Factors associated with amniopatch success (i.e. cessation of leakage with normalization of amniotic fluid volume) were tested univariately and in multivariate logistic regression models...
August 10, 2016: Journal of Maternal-fetal & Neonatal Medicine
Andrew H Chon, Gustavo H de Oliveira, Kevin V Lemley, Lisa M Korst, Ryan D Assaf, Ramen H Chmait
INTRODUCTION: Although mortality has decreased for fetuses with lower urinary tract obstruction treated with vesicoamniotic shunt (VAS) placement, survivors remain at risk for long-term renal impairment. We tested the association of fetal serum β2-microglobulin (fsβ2M) with postnatal renal function in these patients, hypothesizing that fsβ2M may predict such renal impairment. MATERIALS AND METHODS: fsβ2M was obtained in patients undergoing VAS placement. The primary outcome was renal function at 3-12 months of life, as assessed by a pediatric nephrologist using medical records...
September 8, 2016: Fetal Diagnosis and Therapy
Jennifer R King, Charlotte L Conturie, Joseph G Ouzounian, Lisa M Korst, Arlyn Llanes, Ramen H Chmait
INTRODUCTION: Umbilical cord occlusion (UCO) utilizing laser photocoagulation is often not considered an option for selective termination after 20 weeks of gestation due to reported limitations of the procedure because of umbilical cord size. We compared outcomes after laser umbilical cord occlusion (L-UCO) before and after 20 weeks of gestation. MATERIALS AND METHODS: We examined all patients with monochorionic- diamniotic twins and higher-order multiples (monoamniotic excluded) that underwent L-UCO at our facility between 2006 and 2014...
August 31, 2016: Fetal Diagnosis and Therapy
Ashwant Kumar Vadepally, Brig Ramen Sinha, A V S S Subramanya, Anmol Agarwal
PURPOSE: The optimal route of intubation that may be planned for different oral and maxillofacial surgical manoeuvres. MATERIALS AND METHODS: A study was performed on patients who underwent nasal, oral or submental route of intubation for elective oral and maxillofacial surgery under general anaesthesia. The study variables were the anaesthetic and surgeon factors that should be taken into consideration before intubation and during surgery, and also algorithms for uneventful surgical procedures...
June 2016: Journal of Maxillofacial and Oral Surgery
D A L Pedreira, E A Reece, R H Chmait, E V Kontopoulos, R A Quintero
No abstract text is available yet for this article.
August 2016: Ultrasound in Obstetrics & Gynecology
Rubén A Quintero, Eftichia Kontopoulos, Ramen H Chmait
OBJECTIVE: Laser ablation of all placental vascular anastomoses is the optimal treatment for twin-twin transfusion syndrome (TTTS). However, two important controversies are apparent in the literature: (a) a gap between concept and performance, and (b) controversy regarding whether all the anastomoses can be identified endoscopically and whether blind lasering of healthy placenta is justified. The purpose of this article is: (a) to address the potential source of the gap between concept and performance by analyzing the fundamental steps needed to successfully accomplish the surgery, and (b) to discuss the resulting competency benchmarks reported with the different surgical techniques...
June 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
Eftichia Kontopoulos, Ramen H Chmait, Ruben A Quintero
OBJECTIVE: The purpose of this article is to review the definition of twin-to-twin transfusion syndrome (TTTS) and the sonographic diagnostic assessment of these cases prior to therapy. MATERIALS AND METHODS: The article addresses the terminology used to refer to the condition and describes the systematic ultrasound assessment of the condition, including the ultrasound diagnosis, the staging of the disease, cervical assessment and pre-operative mapping. RESULTS: From an etymologic and medical point of view, the term 'fetofetal transfusion' is more appropriate than 'TTTS'...
June 2016: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
Li Zhou, Adriana Nicholson Vest, Raymond A Peck, Jonathan P Sredl, Xuechen Huang, Yaniv Bar-Cohen, Michael J Silka, Jay D Pruetz, Ramen H Chmait, Gerald E Loeb
This paper discusses the technical and safety requirements for cardiac pacing of a human fetus with heart failure and hydrops fetalis secondary to complete heart block. Engineering strategies to meet specific technical requirements were integrated into a systematic design and implementation consisting of a novel fetal micropacemaker, a percutaneous implantation system, and a sterile package that enables device storage and recharging maintenance in a clinical setting. We further analyzed observed problems on myocardial fixation and pacing lead fatigue previously reported in earlier preclinical trials...
March 28, 2016: Medical & Biological Engineering & Computing
Jodie K Votava-Smith, Pisit Pitukcheewanont, Linda M Randolph, Ramen H Chmait
Recipients of the twin-twin transfusion syndrome (TTTS) often develop cardiac manifestations, but arterial calcification has rarely been reported. Generalized arterial calcification of infancy (GACI) is a genetic disorder with high infantile mortality. We report the case of a TTTS recipient with moderate cardiomyopathy at diagnosis who developed progressive calcification of the pulmonary arteries and aorta after successful in utero laser therapy. Postnatally, both twins were diagnosed with a heterozygous ABCC6 gene mutation associated with GACI...
March 17, 2016: Fetal Diagnosis and Therapy
K Rajkumar, P Mukhopadhyay, Ramen Sinha, T K Bandyopadhyay
PURPOSE: The purpose of this study was to clinically and radiologically evaluate reduction and fixation of isolated zygomatic complex (ZMC) fractures treated by Y modification of the transconjunctival approach. PATIENTS AND METHODS: A prospective evaluation of ten patients was undertaken for a period of 6 months using this modified approach from Jan 2012 to Jun 2013. Patients were examined preoperatively and post operatively at the end of 6 months for symmetry discrepancies involving A-P globe projection, lateral canthal level, malar projection and diplopia in direct and extreme gazes...
March 2016: Journal of Maxillofacial and Oral Surgery
Kristi R Van Winden, Rubén A Quintero, Eftichia V Kontopoulos, Lisa M Korst, Arlyn Llanes, Ramen H Chmait
INTRODUCTION: We examined placental weight characteristics associated with donor selective intrauterine growth restriction (SIUGR) among patients with twin-twin transfusion syndrome (TTTS) who underwent laser surgery. MATERIALS AND METHODS: Fresh placental specimens were studied. Pregnancies with higher-order multiples, fetal demise, or disrupted or nonsubmitted placental specimens were excluded. Placental characteristics prospectively collected included total placental weight, individual placental weight, and placental share...
2016: Fetal Diagnosis and Therapy
S Revanth Kumar, Ramen Sinha, Uday Kiran Uppada, B V Ramakrishna Reddy, Dushyanth Paul
PURPOSE: The aim of this study was to assess the influence of position of mandibular 3rd molar on angle and condylar fractures. MATERIALS AND METHODS: Panoramic radiographs were used to determine the mandibular fracture patterns based on the presence or absence of the third molar. RESULTS: Of the 64 patients with mandibular fractures, condyle and angle fractures were found to be 67 and 33 % respectively. The greatest percentage (75 %) of condylar fractures were associated with erupted third molar teeth, and 25 % had impacted teeth...
December 2015: Journal of Maxillofacial and Oral Surgery
Lakshi Prasad Bhuyan, Paban Borah, Santanu Sabhapondit, Ramen Gogoi, Pradip Bhattacharyya
The spatial distribution of theaflavin and thearubigin fractions and their impact on black tea quality were investigated using multivariate and geostatistics techniques. Black tea samples were collected from tea gardens of six geographical regions of Assam and West Bengal, India. Total theaflavin (TF) and its four fractions of upper Assam, south bank and North Bank teas were higher than the other regions. Simple theaflavin showed highest significant correlation with tasters' quality. Low molecular weight thearubigins of south bank and North Bank were significantly higher than other regions...
December 2015: Journal of Food Science and Technology
Gemma Mazzuoli-Weber, Michael Schemann
For long it was believed that a particular population of enteric neurons, referred to as intrinsic primary afferent neuron (IPAN)s, encodes mechanical stimulation. We recently proposed a new concept suggesting that there are in addition mechanosensitive enteric neurons (MEN) that are multifunctional. Based on firing pattern MEN behaved as rapidly, slowly, or ultra-slowly adapting RAMEN, SAMEN, or USAMEN, respectively. We aimed to validate this concept in the myenteric plexus of the gastric corpus, a region where IPANs were not identified and existence of enteric sensory neurons was even questioned...
2015: Frontiers in Cellular Neuroscience
Eva M Kugler, Klaus Michel, Florian Zeller, Ihsan E Demir, Güralp O Ceyhan, Michael Schemann, Gemma Mazzuoli-Weber
The particular location of myenteric neurons, sandwiched between the 2 muscle layers of the gut, implies that their somata and neurites undergo mechanical stress during gastrointestinal motility. Existence of mechanosensitive enteric neurons (MEN) is undoubted but many of their basic features remain to be studied. In this study, we used ultra-fast neuroimaging to record activity of primary cultured myenteric neurons of guinea pig and human intestine after von Frey hair evoked deformation of neurites and somata...
2015: Frontiers in Cellular Neuroscience
Denise A L Pedreira, Nelci Zanon, Koshiro Nishikuni, Renato A Moreira de Sá, Gregório L Acacio, Ramen H Chmait, Eftichia V Kontopoulos, Rubén A Quintero
BACKGROUND: A recent randomized clinical trial named Management of Myelomeningocele Study (MOMS trial) showed that prenatal correction of open spina bifida (OSB) via open fetal surgery was associated with improved infant neurological outcomes relative to postnatal repair, but at the expense of increased maternal morbidity. OBJECTIVE: We sought to report the final results of our phase I trial (Cirurgia Endoscópica para Correção Antenatal da Meningomielocele [CECAM]) on the feasibility, safety, potential benefits, and side effects of the fetoscopic treatment of OSB using our unique surgical technique...
January 2016: American Journal of Obstetrics and Gynecology
Ramen H Chmait, Andrew H Chon, Sheree M Schrager, Eftichia V Kontopoulos, Rubén A Quintero, Douglas L Vanderbilt
OBJECTIVE: To assess fetal growth after laser surgery for TTTS at the time of prenatal diagnosis, birth, and at 2years of age. DESIGN/METHODS: Growth data were collected from surviving children treated between 2007 and 2010 as part of a study to assess neurodevelopment at 24months (±6weeks) corrected age. Fetal weights were obtained via ultrasound using Hadlock's formula at the time of preoperative assessment for laser surgery. Birth weights were recorded by the staff at the delivering institutions...
December 2015: Early Human Development
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