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Dermal filler

Ching Soong Khoo, Hui Jan Tan, Syazarina Sharis Osman
BACKGROUND Dermal fillers are increasingly used for medical and aesthetic purposes in clinical practice. Common complications following filler injections include bruising, itching, infections, allergic reactions, and tissue necrosis. This case is the first report of Herpes simplex virus type 1 (HSV-1) encephalitis as a possible complication of dermal filler injection. CASE REPORT A 27-year-old woman with no past medical history presented with altered mental state, headaches, and seizures. She had a nasal dermal filler injection for aesthetic purpose five weeks before her acute presentation...
July 13, 2018: American Journal of Case Reports
Jennifer L Herrmann, Rachel K Hoffmann, Chloe E Ward, Joshua M Schulman, Roy C Grekin
BACKGROUND: Injectable dermal fillers are becoming increasingly popular for soft tissue augmentation and rejuvenation. Most contemporary biodegradable products are derived from hyaluronic acid, calcium hydroxylapatite, or poly-L-lactic acid. Achievement of desired cosmetic outcomes is largely dependent on selection of the optimal injectable product based on the chemical composition, the physiologic interactions with surrounding tissue, product longevity, and a thorough understanding of potential adverse reactions...
July 9, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Peter H J Keizers, Celine Vanhee, Eef M W van den Elzen, Wim H de Jong, Bastiaan J Venhuis, Hennie M Hodemaekers, Paul Schwillens, Daan G W Lensen
Facial treatments with dermal fillers for medical or esthetic purposes occasionally give rise to adverse effects, ranging from temporary effects such as reddening of the skin, to long term effects such as hardening of tissue. There appears to be a relationship between the lifetime of the filler product and the risk for adverse effects. The lifetime of hyaluronic acid-based fillers is dependent on the presence and amount of crosslinking agents such as 1,4-butanediol diglycidyl ether (BDDE). It would therefore make sense to establish methodology to analyze the crosslinking grade of HA-based filler products on a routine basis...
July 2, 2018: Journal of Pharmaceutical and Biomedical Analysis
Barend Andre Stander, Fiona A van Vollenstee, Karlien Kallmeyer, Marnie Potgieter, Annie Joubert, Andri Swanepoel, Lara Kotze, Sean Moolman, Michael S Pepper
The field of dermal fillers is evolving rapidly and numerous products are currently on the market. Biodegradable polymers such as polycaprolactone (PCL) have been found to be compatible with several body tissues, and this makes them an ideal material for dermal filling purposes. Hollow PCL spheres were developed by the Council for Scientific and Industrial Research (CSIR) to serve both as an anchor point and a "tissue harbour" for cells. Particles were tested for cytotoxicity and cell adherence using mouse embryo fibroblasts (MEF)...
2018: PloS One
Dagmar Scharschmidt, Ursula Mirastschijski, Simone Preiss, Elmar Brähler, Tanja Fischer, A Borkenhagen
BACKGROUND: The demand for minimally invasive cosmetic procedures has continued to rise, especially in Germany, yet few studies have examined this patient population. The literature in Germany has repeatedly voiced the speculation that users of minimally invasive, skin-rejuvenating procedures displayed a higher tendency toward dysmorphic behavior patterns or, respectively, other abnormal personality traits. OBJECTIVES: The aim of this study was to investigate body image, personality traits, quality of life, and socioeconomic parameters in users of botulinum toxin and/or facial fillers...
June 11, 2018: Aesthetic Plastic Surgery
Ali Sahan, Tamer Funda
INTRODUCTION: Lip augmentation procedures with hyaluronic acid dermal fillers have become increasingly popular worldwide because full lips are often considered beautiful and youthful. The goal of a lip augmentation procedure is to create smooth lips with adequate volume and a natural appearance. Various techniques for lip augmentation have been utilized and described. METHODS: In the four-point injection technique, the lips were divided equally into right side and left side...
June 2018: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
Martha Fang, Eqram Rahman, Krishan Mohan Kapoor
Hyaluronic acid dermal fillers are becoming popular all over the world, but due to the presence of many blood vessels in the face, there is always a small possibility of vascular complications. We present a case with the ischemic involvement of chin and neck skin after accidental submental artery involvement after hyaluronic acid filler injection for chin region. Impending skin necrosis on the chin and upper neck on the right side was diagnosed quickly by observing the skin changes in the immediate postfiller phase...
May 2018: Plastic and Reconstructive Surgery. Global Open
Michele Pascali, Davide Quarato, Francesco Carinci
The ideal perioral and lip rejuvenation technique provides the longest period of efficacy, lowest complication rate, and best aesthetic results. Genetics, intrinsic aging, sun exposure and repetitive muscle twitching of the orbicularis oris produce angular, radial, and vertical lines of the perioral lines and, for this reason, the needs of patients in the treatment of this anatomical area can range from simple lip enhancement to a broader and more comprehensive treatment with simultaneous correction of perioral wrinkles...
June 18, 2018: Rejuvenation Research
U Wollina, C Wiegand, U-C Hipler
Soft tissue fillers are used in aesthetic medicine for volumizing and for contouring. Calcium hydroxylapatite (CaHA) is a fully biodegradable biostimulatory filler. The study presents results of in vitro biocompatibility and cytotoxicity investigations performed on CaHA and illustrates its clinical effects. We used a human cell culture model for in vitro studies with HaCaT keratinocytes and human dermal fibroblasts, known to be a sensitive cell type for biocompatibility and cytotoxicity. Cells were exposed to different concentrations of CaHA (Radiesse®)...
May 2018: Georgian Medical News
Gabriela Casabona, Paula Barreto Marchese, José Raúl Montes, Carl S Hornfeldt
BACKGROUND: Hyaluronic acid (HA) dermal fillers are commonly used in cosmetic dermatology. Due to differences in their physical characteristics, HA fillers demonstrate different sensitivity to degradation by hyaluronidase (Hase) because of HA concentration and differences in cross-linking. Similarly, there are differences in the activity of Hase products depending on source and concentration. OBJECTIVE: The primary objective was to demonstrate the differences in potency and activity of 5 Hase products when used to degrade 5 different HA products using a human in vivo model...
June 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Hong-San Kim, Kyu-Lim Lee, Young-Chun Gil, Kyung-Seok Hu, Tanvaa Tansatit, Hee-Jin Kim
[BACKGROUND]: Understanding the topography of the blood vessels distributed around the nasolabial fold (NLF) region is essential for ensuring the safety of dermal filler injections into the NLF. The purpose of this study was to provide anatomical information on the IOA distribution and its relationship with the FA for use in clinical procedures involving filler injection during NLF augmentation. [METHODS]: Seventy-two embalmed hemifaces (42 males and 30 females) from Thai and Korean cadavers were used in this study...
June 4, 2018: Plastic and Reconstructive Surgery
Gabriel F Santiago, Jordan Terner, Amir Wolff, Jeffrey Teixeira, Henry Brem, Judy Huang, Chad R Gordon
INTRODUCTION: An irregular craniofacial contour along the temporal fossa, known commonly as 'temporal hollowing deformity,' (THD) can arise from multiple etiologies. In fact, up to half of all patients who undergo neurosurgical pterional dissections develop some form of temporal contour deformities. Unfortunately, temporal hollowing correction remains surgically challenging with many techniques resulting in high rates of failure and/or morbidity. METHODS: Herein, we describe anatomy contributing to postsurgical temporal deformity as well as time-tested prevention and surgical correction techniques...
May 31, 2018: Journal of Craniofacial Surgery
Mariel Angelou A Parulan, Gangadhara Sundar, Jeffrey Hy Lum, Umashankar Ramachandran
We report a case of a 49-year old East-Asian female who presented with delayed onset granuloma formation at the right medial lower eyelid area. The clinical and radiologic presentation with pathologic correlation following synthetic hyaluronic acid filler injection and its management are described along with a review of literature following dermal-filler injections types. Dermal-filler-related granuloma formation should be included in the differential diagnoses of periorbital inflammatory and mass lesions. It is recommended that clinicians who perform this procedure should discuss these risks and possible late complications with patients and provide them with the relevant product information of the injected filler for appropriate management should such early or late complications occur...
May 29, 2018: Orbit
Francisca Teixeira-Lopes, Ana Dias, Rita Luís, Leonardo Ferreira
No abstract text is available yet for this article.
May 19, 2018: Archivos de Bronconeumología
Peeyush P Sharma, Dave Krishan Sharma, Andrew Carr
INTRODUCTION: The emergence of hyaluronic acid dermal fillers with lidocaine has transformed the minimally invasive treatment of wrinkles, lines and folds of the face. Patients can be treated quickly, painlessly and without the need for large doses of lidocaine. Therefore, it is important to scientifically evaluate the merits of lidocaine-containing products over those without. METHODS: The two products, with (UJU) and without lidocaine (UJ), were randomly injected into nasolabial folds of 75 healthy volunteers with varying skin types in a split face study, age ranging 26-60 years...
May 14, 2018: Aesthetic Plastic Surgery
Ewa Skrzypek, Barbara Górnicka, Daisy Miriam Skrzypek, Mlosek Robert Krzysztof
In aesthetic medicine, there has been an ongoing search for an ideal dermal filler to offer zero complication rate. Polycaprolactone-based dermal filler (PCL) has been available since 2009. The purpose of the paper was to present a case of granuloma as a complication of PCL injection, which has not been reported so far by other researchers. A 68-year-old female was injected with PCL. One year later, nodules accompanied by bluish skin discoloration developed within the injection site. Ultrasound and histopathology studies were performed...
May 14, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Leonie W Schelke, Tom S Decates, Claudia I M van der Lugt, Levi Pelzer, Gabrielle de Mey, Peter J Velthuis
BACKGROUND: For complications caused by filler treatments, in general, two treatment regimens are advised: systemic drugs and surgical removal of the material. Another possible treatment option would be removal of the material by intralesional laser treatment. METHODS: Two hundred forty-two patients with complications caused by fillers were treated with intralesional laser treatment. RESULTS: In the majority of patients, an improvement was achieved (92 percent), in 9 percent the complication was resolved, and in 3 percent it was not improved (unknown in the rest)...
June 2018: Plastic and Reconstructive Surgery
Chenglong Wang, Sisi Luan, Adriana C Panayi, Minqiang Xin, Bobin Mi, Jie Luan
BACKGROUND: Hyaluronic acid (HA) gel is a widely used dermal filler for the correction facial volume loss. The incorporation of lidocaine with HA provides a pain-relieving alternative for individuals considering facial rejuvenation. The aim of this systematic review and meta-analysis is to compare the effectiveness and safety of HA with lidocaine (HAL) with that of HA without lidocaine for the treatment of nasolabial folds (NLFs). METHODS: Studies were identified using the electronic databases PubMed, Embase, Cochrane Central Register of Controlled Trials and Web of Science from inception up to January 2018...
May 8, 2018: Aesthetic Plastic Surgery
Alejandro Ismael Lorenzo-Pouso, Abel García-García, Mario Pérez-Sayáns
OBJECTIVE: To report conservative treatment based on the use of dermal fillers for a case of recurrent angular cheilitis. CASE REPORT: An 80-year-old patient with a history of recurrent angular cheilitis that was not resolved with a conventional approach sought treatment. Complete remission of the pathology was achieved with the injection of hyaluronic acid fillers. CONCLUSION: This case illustrates the potential of nonsurgical facial aesthetics (NSFA) for treating this common pathology among elderly people...
June 2018: Gerodontology
Gary Monheit, Kenneth Beer, Bhushan Hardas, Pearl E Grimes, Barry M Weichman, Vince Lin, Diane K Murphy
BACKGROUND: Juvéderm Vollure XC (VYC-17.5L) belongs to a family of nonanimal hyaluronic acid (HA) gels based on the Vycross technology platform. OBJECTIVE: To evaluate the safety and effectiveness of VYC-17.5L for correction of moderate to severe nasolabial folds (NLFs) compared with a control HA dermal filler. METHODS: In this double-blind study, 123 adults with 2 moderate or severe NLFs as measured on the 5-point photonumeric NLF severity scale (NLFSS) were randomized to VYC-17...
May 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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