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D3 vitamin growth

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https://www.readbyqxmd.com/read/29233620/regulation-of-extracellular-matrix-vesicles-via-rapid-responses-to-steroid-hormones-during-endochondral-bone-formation
#1
REVIEW
Niels Asmussen, Zhao Lin, Michael J McClure, Zvi Schwartz, Barbara D Boyan
Endochondral bone formation is a precise and highly ordered process whose exact regulatory framework is still being elucidated. Multiple regulatory pathways are known to be involved. In some cases, regulation impacts gene expression, resulting in changes in chondrocyte phenotypic expression and extracellular matrix synthesis. Rapid regulatory mechanisms are also involved, resulting in release of enzymes, factors and micro RNAs stored in extracellular matrisomes called matrix vesicles. Vitamin D metabolites modulate endochondral development via both genomic and rapid membrane-associated signaling pathways...
December 9, 2017: Steroids
https://www.readbyqxmd.com/read/29216499/vitamin-d3-decreases-glycolysis-and-invasiveness-and-increases-cellular-stiffness-in-breast-cancer-cells
#2
Julianna Maria Santos, Zeina Shereen Khan, Maliha Tabassum Munir, Kaiser Tarafdar, Shaikh Mizanoor Rahman, Fazle Hussain
Breast cancer is one of the major causes of death in the USA. Cancer cells, including breast, have high glycolysis rates to meet their energy demands for survival and growth. Vitamin D3 (VD3) is important for many important physiological processes such as bone mineralization, but its anticancer role is yet to be proven. We find that VD3 treatment significantly down-regulates glycolytic enzymes and genes and decreases glucose uptake - for both lowly metastatic MCF-7 and highly metastatic MDA-MB-231 (MB231) breast cancer cells...
November 2, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29203197/safety-evaluation-of-dietary-levels-of-25-hydroxyvitamin-d3-in-growing-calves
#3
Pietro Celi, Scot Williams, Mark Engstrom, Joe McGrath, James La Marta
The objective of this study was to evaluate the safety of 25-OH-D3 addition to the diet of bovine calves. The investigation was conducted as a feeding experiment for 90 days. 40 calves were allotted to four groups: T1 - control group which received 30 IU vitamin D3/kg feed, and three experimental groups, which received 25-OH-D3 in increasing dosages: T2 - 25-OH-D3 at 1.7 μg/kg, T3 - 25-OH-D3 at 5.1 μg/kg and T4 - 25-OH-D3 at 8.5 μg/kg. All calves in the four groups gained weight continually: no growth depression was observed...
December 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29201067/hereditary-vitamin-d-resistant-rickets-clinical-laboratory-and-genetic-characteristics-of-2-iranian-siblings
#4
Ali A Ghazi, Azita Zadeh-Vakili, Marjan Zarif Yeganeh, Shahram Alamdari, Atieh Amouzegar, Ali Akbar Khorsandi, Alireza Amirbaigloo, Fereidoun Azizi
Purpose and Methods: Hereditary vitamin D resistant rickets (HVDRR) is a rare disease that presents with signs and symptoms of rickets, alopecia, and growth retardation during the early years of life. The disease is caused by mutations in the vitamin D receptor (VDR) gene, which leads to unresponsiveness of the mutant receptor to 1-25(OH) 2 D3. The disease is transmitted as an autosomal recessive disorder and is found with equal frequency in males and females. The disease is rarely encountered and only about 100 cases are reported so far...
July 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29187432/paclitaxel-carboplatin-and-1-25-d3-inhibit-proliferation-of-endometrial-cancer-cells-in-vitro
#5
Tea Kuittinen, Päivi Rovio, Synnöve Staff, Tiina Luukkaala, Anne Kallioniemi, Seija Grénman, Marita Laurila, Johanna Mäenpää
BACKGROUND/AIM: Endometrial cancer cells are known to be sensitive to carboplatin and paclitaxel. Furthermore, vitamin D (1,25-D3) has been reported to inhibit endometrial cancer cell growth both as a single agent and combined with carboplatin. However, there are no studies comparing the effect of paclitaxel and carboplatin as single agents vs. in combination in endometrial cancer cell lines. Neither has the effect of 1,25-D3 been studied with paclitaxel. The present study investigated the effect of paclitaxel, carboplatin and 1,25-D3 on the growth of endometrial cancer cells in vitro...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29182680/differential-activity-of-2-methylene-19-nor-vitamin-d-analogs-on-growth-factor-gene-expression-in-rhino-mouse-skin-and-comparison-to-all-trans-retinoic-acid
#6
Jamie M Ahrens, James D Jones, Nirca J Nieves, Ann M Mitzey, Hector F DeLuca, Margaret Clagett-Dame
While all 2-methylene-19-nor analogs of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) tested produce an increase in epidermal thickness in the rhino mouse, only a subset reduce utricle size (comedolysis). All-trans retinoic acid (atRA) also causes epidermal thickening and a reduction in utricle size in the rhino mouse. We now report that 2-methylene-19-nor-(20S)-1α-hydroxybishomopregnacalciferol (2MbisP), a comedolytic analog, increases epidermal thickening more rapidly than does atRA, while both reduce utricle area at an equal rate...
2017: PloS One
https://www.readbyqxmd.com/read/29141476/comparison-of-sun-exposure-versus-vitamin-d-supplementation-for-pregnant-women-with-vitamin-d-deficiency
#7
Maryam Hajhashemi, Azadeh Khorsandi, Fedyeh Haghollahi
INTRODUCTION: Maternal vitamin D deficiency is widespread health problem which is more important in pregnant women which affects fetus growth and bone development. The aim of this study was to evaluate the effect of sun exposure versus vitamin D supplementation for pregnant women with vitamin D deficiency. MATERIALS AND METHODS: This prospective clinical trial was performed on 87 pregnant women with vitamin D deficiency. Group A was treated with vitamin D 4000 IU per day for 10 weeks, while group B was recommended for sun exposure for 30 minutes daily (30% body surface area) for 10 weeks in summer and between 10 am-4 pm in direct sunlight...
November 15, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29112142/igfbp-3-interacts-with-the-vitamin-d-receptor-in-insulin-signaling-associated-with-obesity-in-visceral-adipose-tissue
#8
Inmaculada Moreno-Santos, Daniel Castellano-Castillo, María Fernanda Lara, Jose Carlos Fernandez-Garcia, Francisco Jose Tinahones, Manuel Macias-Gonzalez
Adipose tissue has traditionally only been considered as an energy storage organ. Nevertheless, the importance of this tissue in systemic physiology and, especially, in systemic inflammation has been highlighted in recent years. Adipose tissue expresses proteins related to vitamin D (VD) metabolism, and it has been proposed that it can act as a VD storage tissue. The active form of VD, 1,25-dihydroxyvitamin D3 (1,25(OH)₂D₃), is able to modify adipocyte and adipose tissue physiology via the VD receptor (VDR), decreasing the expression of pro-inflammatory cytokines in adipose tissue...
November 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29096022/current-recommended-vitamin-d-prenatal-supplementation-and-fetal-growth-results-from-china-anhui-birth-cohort-study
#9
Rui-Xue Tao, Deng-Hon Meng, Jing-Jing Li, Shi-Lu Tong, Jia-Hu Hao, Kun Huang, Fang-Biao Tao, Peng Zhu
Context: Maternal vitamin D insufficiency have been associated with fetal growth restriction. However, the effect ofmaternal vitamin D supplementation on fetal growth has not been confirmed. Objective: To assess the effect of maternal vitamin D supplementation recommended byIOMduring pregnancy on the neonatal vitamin D status and the risk of small for gestational age (SGA). Design and Participants: As part of the China-Anhui Birth Cohort study, maternal sociodemographic characteristics, food intake, lifestyle, information of vitamin D supplementation and birth outcomes were prospectively collected...
October 31, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29075077/bone-histo-morphology-in-chronic-kidney-disease-mineral-bone-disorder
#10
Khuraijam Bembem, Tejinder Singh, Narinder Pal Singh, Alpana Saxena, Shyama Lata Jain
Chronic Kidney Disease-Mineral Bone Disorder(CKD-MBD) is a systemic disorder of the mineral and bone metabolism seen in patients with Chronic Kidney Disease(CKD). It is manifested by either one or a combination of the following: (a) Abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism. (b) Abnormalities in bone turnover, mineralization, volume, linear growth, or strength. (c) Vascular or other soft- tissue calcification. Renal osteodystrophy measures the skeletal component of CKD-MBD. To study the histomorphology of bone marrow biopsy in patients with CKD-MBD and correlate the histological features of bone biopsy with the clinicobiochemical parameters...
December 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29074843/a-quantitative-point-of-need-assay-for-the-assessment-of-vitamin-d3-deficiency
#11
S Vemulapati, E Rey, D O'Dell, S Mehta, D Erickson
Vitamin D is necessary for the healthy growth and development of bone and muscle. Vitamin D deficiency, which is present in 42% of the US population, is often undiagnosed as symptoms may not manifest for several years and long-term deficiency has been linked to osteoporosis, diabetes and cancer. Currently the majority of vitamin D testing is performed in large-scale commercial laboratories which have high operational costs and long times-to-result. Development of a low-cost point-of-need assay could be transformative to deficiency analysis in limited-resource settings...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29074825/-update-on-recent-progress-in-vitamin-d-research-vitamin-d-receptor-and-the-nuclear-receptor-superfamily
#12
Makoto Makishima
The vitamin D receptor(VDR)is a ligand-dependent transcription factor of the nuclear receptor superfamily. VDR belongs to the NR1I subfamily along with other nuclear receptors involved in xenobiotic metabolism, such as pregnane X receptor. The oxysterol receptors liver X receptors α/β and the bile acid receptor farnesoid X receptor belong to the NR1H subfamily, which are closely related to the NR1I subfamily. NR1I and NR1H nuclear receptors form heterodimers with retinoid X receptor. The active form of vitamin D, 1α,25-dihydroxyvitamin D3[1,25(OH)2D3], acts as a physiological VDR ligand, and regulates various physiological processes, including calcium and bone metabolism, cellular growth and differentiation, immunity, and cardiovascular function...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29072386/-genetic-disorders-of-renal-phosphate-handling
#13
REVIEW
Daniella Magen
Hereditary disorders of renal phosphate handling comprise a diverse group of genetic diseases, usually characterized by excessive urinary phosphate wasting and a negative phosphate balance. In the minority of cases, perturbations of renal phosphate handling are associated with excessive urinary phosphate reabsorption, leading to pathological hyperphosphatemia. Inorganic phosphate is an essential mineral in the human body, playing a crucial role in cellular metabolism and skeletal mineralization. Whole body phosphate balance is maintained by a highly controlled equilibrium between intestinal uptake, skeletal deposition and renal excretion...
October 2017: Harefuah
https://www.readbyqxmd.com/read/29061804/1%C3%AE-25-oh-2d3-analog-mart-10-inhibits-neuroendocrine-tumor-cell-metastasis-after-vegf-a-stimulation
#14
Kun-Chun Chiang, Chun-Nan Yeh, Jong-Hwei S Pang, Jun-Te Hsu, Ta-Sen Yeh, Li-Wei Chen, Sheng-Fong Kuo, Masashi Takano, Tai C Chen, Atsushi Kittaka, Po-Jen Hsieh, Horng-Heng Juang
AIMS: Pancreatic neuroendocrine tumors (PanNETs) are usually diagnosed in an advanced stage. Most patients with PanNETs die of metastasis. Vascular endothelial growth factor-A (VEGF-A) is a strong stimulator of angiogenesis and tumor metastasis. We aimed to investigate the effect of MART-10 [19-nor-2α-(3-hydroxypropyl)-1α,25(OH)2D3], a 1α,25-dihydroxy-vitamin D3 (1α,25(OH)2D3) analog, on PanNET cell metastasis after VEGF-A stimulation. MATERIALS AND METHODS: Migration and invasion assays, western blot, and immunofluorescent staining were applied in this study...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29026610/selective-blood-sampling-for-fgf-23-in-tumor-induced-osteomalacia
#15
Hans-Christof Schober, Christian Kneitz, Franziska Fieber, Kathrin Hesse, Henry Schroeder
Tumor-induced osteomalacia (TIO) is caused by the hormone fibroblast growth factor 23 (FGF-23). It is mainly produced in the tissue of mesenchymal tumors. Patients with TIO frequently suffer from a chronic decompensated pain syndrome and/or muscle weakness with postural deformity. Despite the severity of the disease, the diagnosis is frequently established late. In some cases, it takes several years to establish the condition. This case report concerning a 68-year old woman demonstrates the selective blood sampling for FGF-23 as path-breaking diagnostics to confirm the diagnosis of a neuroendocrine tumor...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29016653/randomized-trial-of-two-doses-of-vitamin-d3-in-preterm-infants-32-weeks-dose-impact-on-achieving-desired-serum-25-oh-d3-in-a-nicu-population
#16
RANDOMIZED CONTROLLED TRIAL
Ann Anderson-Berry, Melissa Thoene, Julie Wagner, Elizabeth Lyden, Glenville Jones, Martin Kaufmann, Matthew Van Ormer, Corrine Hanson
BACKGROUND: Recommendations for vitamin D supplementation for preterm infants span a wide range of doses. Response to vitamin D supplementation and impact on outcomes in preterm infants is not well understood. OBJECTIVE: Evaluate serum 25(OH)D3 concentration changes after 4 weeks in response to two different doses of vitamin D3 supplementation in a population of premature infants and quantify the impact on NICU outcomes. DESIGN: 32 infants born at 24-32 weeks gestation were prospectively randomized to receive 400 or 800 IU/day vitamin D3 supplementation...
2017: PloS One
https://www.readbyqxmd.com/read/28938396/transgenic-expression-of-the-vitamin-d-receptor-restricted-to-the-ileum-cecum-and-colon-of-vitamin-d-receptor-knockout-mice-rescues-vitamin-d-receptor-dependent-rickets
#17
Puneet Dhawan, Vaishali Veldurthy, Ghassan Yehia, Connie Hsaio, Angela Porta, Ki-In Kim, Nishant Patel, Liesbet Lieben, Lieve Verlinden, Geert Carmeliet, Sylvia Christakos
Although the intestine plays the major role in 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] action on calcium homeostasis, the mechanisms involved remain incompletely understood. The established model of 1,25(OH)2D3-regulated intestinal calcium absorption postulates a critical role for the duodenum. However, the distal intestine is where 70% to 80% of ingested calcium is absorbed. To test directly the role of 1,25(OH)2D3 and the vitamin D receptor (VDR) in the distal intestine, three independent knockout (KO)/transgenic (TG) lines expressing VDR exclusively in the ileum, cecum, and colon were generated by breeding VDR KO mice with TG mice expressing human VDR (hVDR) under the control of the 9...
November 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28882103/low-serum-vitamin-d-levels-in-type-2-diabetes-patients-are-associated-with-decreased-mycobacterial-activity
#18
María Teresa Herrera, Yolanda Gonzalez, Fernando Hernández-Sánchez, Guadalupe Fabián-San Miguel, Martha Torres
BACKGROUND: Concurrent diabetes mellitus and tuberculosis represent a significant health problem worldwide. Patients with diabetes mellitus have a high risk of tuberculosis, which may be mediated by an abnormal innate immune response due to hyperglycaemia or low vitamin D levels. METHODS: In the present study, we evaluated inactive vitamin D serum levels and the monocyte response to infection with M. tuberculosis, including phagocytosis of M. tuberculosis, antimycobacterial activity, LL-37, human β defensin-2 and IL-10 gene expression and nitric oxide production, between type 2 diabetes mellitus patients (n = 51) and healthy volunteers (n = 38)...
September 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28878195/1-945-25-dihydroxyvitamin-d3-attenuates-tgf-946-induced-pro-fibrotic-effects-in-human-lung-epithelial-cells-through-inhibition-of-epithelial-mesenchymal-transition
#19
Fei Jiang, Yong Yang, Lian Xue, Bingyan Li, Zengli Zhang
Pulmonary fibrosis is a progressive fibrotic lung disease of persisting lung injury and ineffective wound repair, with poor prognosis. Epithelial-mesenchymal transition (EMT) of alveolar epithelia cells is an early event in the development of pulmonary fibrosis, and transforming growth factor β (TGF-β) is an acknowledged inducer of EMT. Epidemiological studies demonstrated that serum levels of 25-hydroxy-vitamin D were associated with the presence of fibrosis diseases. We investigated whether vitamin D attenuated TGF-β-induced pro-fibrotic effects through inhibiting EMT in human alveolar epithelia A549 cells...
September 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28870263/effect-of-maternal-vitamin-d3-supplementation-on-maternal-health-birth-outcomes-and-infant-growth-among-hiv-infected-tanzanian-pregnant-women-study-protocol-for-a-randomized-controlled-trial
#20
Christopher R Sudfeld, Karim P Manji, Christopher P Duggan, Said Aboud, Alfa Muhihi, David M Sando, Fadhlun M Alwy Al-Beity, Molin Wang, Wafaie W Fawzi
BACKGROUND: Vitamin D has significant immunomodulatory effects on both adaptive and innate immune responses. Observational studies indicate that adults infected with HIV with low vitamin D status may be at increased risk of mortality, pulmonary tuberculosis, and HIV disease progression. Growing observational evidence also suggests that low vitamin D status in pregnancy may increase the risk of adverse birth and infant health outcomes. As a result, antiretroviral therapy (ART) adjunct vitamin D3 supplementation may improve the health of HIV-infected pregnant women and their children...
September 4, 2017: Trials
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