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D3 vitamin growth

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https://www.readbyqxmd.com/read/28216083/maternal-vitamin-d-sufficiency-and-reduced-placental-gene-expression-in-angiogenic-biomarkers-related-to-comorbidities-of-pregnancy
#1
Elizabeth V Schulz, Lori Cruze, Wei Wei, John Gehris, Carol L Wagner
INTRODUCTION: Maternal circulating 25-hydroxyvitamin D [25(OH)D] has been shown to optimize production of 1,25-dihydroxyvitamin D [1,25(OH)2D] during pregnancy at approximately 100nmoles/L, which has pronounced effects on fetal health outcomes. Additionally, associations are noted between low maternal 25(OH)D concentrations and vascular pregnancy complications, such as preeclampsia. To further elucidate the effects of vitamin D activity in pregnancy, we investigated the role of maternal 25(OH)D, the nutritional indicator of vitamin D status, in relation to placental maintenance and, specifically, expression of placental gene targets related to angiogenesis and vitamin D metabolism...
February 12, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28167299/1-25-oh-2d3-and-calcipotriol-its-hypocalcemic-analog-exert-a-long-lasting-anti-inflammatory-and-anti-proliferative-effect-in-synoviocytes-cultured-from-patients-with-rheumatoid-arthritis-and-osteoarthritis
#2
Johanna A Huhtakangas, Johanna Veijola, Sanna Turunen, Anna Karjalainen, Maarit Valkealahti, Tomi Nousiainen, Susanna Yli-Luukko, Olli Vuolteenaho, Petri Lehenkari
OBJECTIVES: We investigated the effects of 1,25-dihydroxy vitamin D3 (1,25(OH)2D3), i.e. biologically active vitamin D and calcipotriol, a vitamin D analogue, on growth and secretion of inflammatory mediators in synovial stromal cells (SSC) of patients with rheumatoid arthritis (RA) or osteoarthritis (OA). METHODS: Synovial stromal cells (SSC) isolated during knee prosthesis surgery from four patients with RA and four with OA were exposed to 1,25(OH)2D3 or calcipotriol with or without stimulation of cells with IL-1β or TNF-α...
February 3, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28166978/growth-performance-parameters-bone-calcification-and-immune-response-of-in-ovo-injection-of-25-hydroxycholecalciferol-and-vitamin-k3-in-male-ross-308-broilers
#3
Tahereh Abbasi, Malak Shakeri, Mojtaba Zaghari, Hamid Kohram
This experiment aimed to evaluate the effects of in ovo injection of 25-hydroxycholecalciferol (25-OH-D3) and Vitamin K3 on growth performance, bone calcification and immune system responses in male Ross 308 broilers. Twelve treatment groups with a total number of 768 experimental hatching eggs, four replications and 16 eggs in each replication were selected to form a completely randomized design of factorial arrangement. Treatments included: (1) distilled water, (2) 0.4 μg D3, (3) 0.4 μg D3 + 2 μg K3, (4) 0...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28159673/ripk1-binds-to-vitamin-d-receptor-and-decreases-vitamin-d-induced-growth-suppression
#4
Waise Quarni, Panida Lungchukiet, Anfernee Tse, Pei Wang, Yuefeng Sun, Ravi Kasiappan, Jheng-Yu Wu, Xiaohong Zhang, Wenlong Bai
Receptor interacting protein kinase 1 (RIPK1) is an enzyme acting downstream of tumor necrosis factor alpha to control cell survival and death. RIPK1 expression has been reported to cause drug resistance in cancer cells, but so far, no published studies have investigated the role of RIPK1 in vitamin D signaling. In the present study, we investigated whether RIPK1 plays any roles in 1,25-dihydroxyvitamin D3 (1,25D3)-induced growth suppression. In our studies, RIPK1 decreased the transcriptional activity of vitamin D receptor (VDR) in luciferase reporter assays independent of its kinase activity, suggesting a negative role of RIPK1 in 1,25D3 action...
February 1, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28133513/effect-of-vitamin-d3-on-biosynthesis-of-estrogen-in-porcine-granulosa-cells-via-modulation-of-steroidogenic-enzymes
#5
So-Hye Hong, Jae-Eon Lee, Sung-Min An, Ye Young Shin, Dae Youn Hwang, Seung Yun Yang, Seong-Keun Cho, Beum-Soo An
Vitamin D3 is a fat-soluble secosteroid responsible for enhancing intestinal absorption of calcium, iron, and other materials. Vitamin D3 deficiency, therefore, can cause health problems such as metabolic diseases, and bone disorder. Female sex hormones including estrogen and progesterone are biosynthesized mainly in the granulosa cells of ovary. In this study, we isolated granulosa cells from porcine ovary and cultured for the experiments. In order to examine the effect of vitamin D3 on the ovarian granulosa cells, the mRNA and protein levels of genes were analyzed by real-time PCR and Western blot assay...
January 2017: Toxicological Research
https://www.readbyqxmd.com/read/28127747/crosstalk-between-sphingolipids-and-vitamin-d3-potential-role-in-the-nervous-system
#6
REVIEW
Mercedes Garcia-Gil, Federica Pierucci, Ambra Vestri, Elisabetta Meacci
Sphingolipids are both structural and bioactive compounds. In particular ceramide and sphingosine 1-phosphate regulate cell fate, inflammation, and excitability. 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2 D3 ), is known to play an important physiological role on growth and differentiation in a variety of cell types, including neural cells, through genomic actions, mediated by its specific receptor, and non-genomic actions resulting in the activation of specific signalling pathways. 1,25(OH)2 D3 and sphingolipids, in particular sphingosine-1-phosphate, share many common effectors, including calcium regulation, growth factors and inflammatory cytokines, but whether they could act synergistically is still unknown...
January 27, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28116596/effects-of-the-supplementation-of-vitamin-d3-on-the-growth-and-vitamin-d-metabolites-in-juvenile-siberian-sturgeon-acipenser-baerii
#7
Liansheng Wang, Hong Xu, Yang Wang, Chang'an Wang, Jinnan Li, Zhigang Zhao, Liang Luo, Xue Du, Qiyou Xu
The objective of this study was to evaluate the effects of the supplementation of vitamin D3 on the growth, vitamin D metabolites, and osteocalcin secretion in juvenile Siberian sturgeon (Acipenser baerii). A 90-day growth trial was conducted with juvenile Siberian sturgeon (initial body weight 3.47 ± 0.14 g) fed seven isonitrogenous and isoenergetic practical diets (45% CP and 13% lipid) containing 60 (basal diet), 240, 450, 880, 1670, 3300, or 1.0 × 10(5) IU/kg feed (D60~D 1.0 × 10(5)) vitamin D3...
January 23, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28115977/efficacy-of-a-novel-formulation-of-l-carnitine-creatine-and-leucine-on-lean-body-mass-and-functional-muscle-strength-in-healthy-older-adults-a-randomized-double-blind-placebo-controlled-study
#8
Malkanthi Evans, Najla Guthrie, John Pezzullo, Toran Sanli, Roger A Fielding, Aouatef Bellamine
BACKGROUND: Progressive decline in skeletal muscle mass and function are growing concerns in an aging population. Diet and physical activity are important for muscle maintenance but these requirements are not always met. This highlights the potential for nutritional supplementation. As a primary objective, we sought to assess the effect of a novel combination of L-Carnitine, creatine and leucine on muscle mass and performance in older subjects. METHOD: Forty-two healthy older adults aged 55-70 years were randomized to receive either a novel L-Carnitine (1500 mg), L-leucine (2000 mg), creatine (3000 mg), Vitamin D3 (10 μg) (L-Carnitine-combination) product (n = 14), L-Carnitine (1500 mg) (n = 14), or a placebo (n = 14) for eight weeks...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28114957/effects-of-calcitriol-1-25-dihydroxy-vitamin-d3-on-the-inflammatory-response-induced-by-h9n2-influenza-virus-infection-in-human-lung-a549-epithelial-cells-and-in-mice
#9
Boxiang Gui, Qin Chen, Chuanxia Hu, Caihui Zhu, Guimei He
BACKGROUND: H9N2 influenza viruses circulate globally and are considered to have pandemic potential. The hyper-inflammatory response elicited by these viruses is thought to contribute to disease severity. Calcitriol plays an important role in modulating the immune response to viral infections. However, its unknown whether calcitriol can attenuate the inflammatory response elicited by H9N2 influenza virus infection. METHODS: Human lung A549 epithelial cells were treated with calcitriol (100 nM) and then infected with an H9N2 influenza virus, or infected and then treated with calcitriol (30 nM)...
January 23, 2017: Virology Journal
https://www.readbyqxmd.com/read/28105733/vitamin-d-supplementation-for-sickle-cell-disease
#10
REVIEW
Htoo Htoo Kyaw Soe, Adinegara Bl Abas, Nan Nitra Than, Han Ni, Jaspal Singh, Abdul Razzak Bin Mohd Said, Ifeyinwa Osunkwo
BACKGROUND: Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis)...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28096966/microrna-297a-regulates-vascular-calcification-by-targeting-fibroblast-growth-factor-23
#11
Shouhua Zheng, Shuijun Zhang, Yan Song, Wenzhi Guo, Wenlong Zhai, Xinguang Qiu, Jianhua Li
OBJECTIVES: Vascular calcification is one the major characteristics in patients with various types of chronic inflammatory disorders. MiRNAs have been shown to be involved in many normal biological functions as well as diseases; however, their role in vascular calcification has not received much attention. MATERIALS AND METHODS: In the current study, we built a vascular calcification rat model using vitamin D3 plus nicotine and analyzed miRNA expression profile by miRNA chip assay...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28068581/vitamin-profiles-in-two-free-living-passerine-birds-under-a-metal-pollution-gradient-a-calcium-supplementation-experiment
#12
Sandra R Ruiz, Silvia Espín, Pablo Sánchez-Virosta, Juha-Pekka Salminen, Thomas M Lilley, Tapio Eeva
Vitamin and carotenoid deficiency may impair development in free-living vertebrates, because of the importance of these micronutrients to growth, antioxidant defense and calcium regulation. Micronutrient and calcium insufficiency can be intensified by metal pollution which can interfere with nutrient homeostasis or indirectly reduce food availability. Furthermore, absorption of dietary heavy metals is dependent on food calcium and vitamin levels. We investigated the effect of calcium on plasma vitamin and carotenoid profiles and how these affected growth and survival in two passerine birds with different calcium turnover living along a metal pollution gradient...
April 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28056993/effect-of-active-vitamin-d3-on-vegf-induced-adam33-expression-and-proliferation-in-human-airway-smooth-muscle-cells-implications-for-asthma-treatment
#13
Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Min Yang, Xue-Jiao Qian, Jiang-Bo Liu
BACKGROUND: Asthma is a chronic respiratory disease characterized by reversible airway obstruction with persistent airway inflammation and airway remodeling, which is associated with increased airway smooth muscle (ASM) mass. Vascular endothelial growth factor (VEGF) has been implicated in inflammatory and airway blood vessel remodeling in asthma. Recent evidence indicates that a deficiency of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) may influence asthma pathogenesis. A disintegrin and metalloproteinase (ADAM)33 has been identified as playing a role in the pathophysiology of asthma...
January 5, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28054069/challenge-and-perspective-the-relevance-of-ultraviolet-uv-radiation-and-the-vitamin-d-endocrine-system-vdes-for-psoriasis-and-other-inflammatory-skin-diseases
#14
Jörg Reichrath, Roman Saternus, Thomas Vogt
During evolution, the ability of many organisms to synthesize vitamin D photochemically represented, and still represents, a major driving factor for the development of life on earth. In humans because not more than 10-20% of the requirement of vitamin D can be satisfied by the diet (under most living conditions in the US and Europe), the remaining 80-90% need to be photochemically synthesized in the skin through the action of solar or artificial ultraviolet-B (UV-B) radiation. The skin is a key organ of the human body's vitamin D endocrine system (VDES), representing both the site of vitamin D synthesis and a target tissue for biologically active vitamin D metabolites...
January 5, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28049234/chronic-kidney-disease-mineral-bone-disorder-in-korean-patients-a-report-from-the-korean-cohort-study-for-outcomes-in-patients-with-chronic-kidney-disease-know-ckd
#15
Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Seung Hyeok Han, Kyu Beck Lee, Joongyub Lee, Kook Hwan Oh, Dong Wan Chae, Soo Wan Kim
This study examined the characteristics of biochemical parameters, bone diseases, and vascular calcification in Korean patients with chronic kidney disease (CKD) not yet on dialysis. Serum levels of fibroblast growth factor 23 (FGF23), intact parathyroid hormone (iPTH), 25-hydroxyvitamin D3 (25D), and 1,25-dihydroxyvitamin D3 (1,25D); lumbar spine, total hip, and femur neck bone mineral densities; and brachial-to-ankle pulse wave velocity (baPWV) representing vascular calcification were measured at baseline for 2,238 CKD patients in the KoreaN Cohort Study for Outcomes in Patients With CKD (KNOW-CKD)...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28040129/efficacies-of-vitamin-d-and-omega-3-polyunsaturated-fatty-acids-on-experimental-endometriosis
#16
Alpaslan Akyol, Memet Şimşek, Raşit İlhan, Behzat Can, Melike Baspinar, Hadice Akyol, H Fatih Gül, Ferit Gürsu, Burçin Kavak, Mustafa Akın
OBJECTIVE: The aim of this study was to investigate the effects of 1,25-dihydroxyvitamin-D3 (vitamin D) and omega-3 polyunsaturated fatty acids (omega-3 PUFA) on experimentally induced endometriosis in a rat model. MATERIALS AND METHODS: A prospective, single-blind, randomized, controlled experimental study was performed on 30 Wistar female rats. Endometriosis was surgically induced by implanting endometrial tissue on the abdominal peritoneum. Four weeks later, a second laparotomy was performed to assess pre-treatment implant volumes and cytokine levels...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28039464/noncalcemic-20-hydroxyvitamin-d3-inhibits-human-melanoma-growth-in-in-vitro-and-in-vivo-models
#17
Cezary Skobowiat, Allen S W Oak, Tae-Kang Kim, Chuan He Yang, Lawrence M Pfeffer, Robert C Tuckey, Andrzej T Slominski
A novel pathway of vitamin D3 (D3) metabolism, initiated by C20-hydroxylation of D3 by CYP11A1, has been confirmed to operate in vivo. Its major product, 20(OH)D3, exhibits antiproliferative activity in vitro comparable to that of 1,25(OH)2D3, but is noncalcemic in mice and rats. To further characterize the antimelanoma activity of 20(OH)D3, we tested its effect on colony formation of human melanoma cells in monolayer culture and anchorage-independent growth in soft agar. The migratory capabilities of the cells and cell-cell and cell-extracellular matrix interactions were also evaluated using transwell cell migration and spheroid toxicity assays...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28025137/nongenomic-effects-of-1%C3%AE-25-dihydroxyvitamin-d3-on-cartilage-formation-deduced-from-comparisons-between-cyp27b1-and-vdr-knockout-mice
#18
Yoshihisa Hirota, Kimie Nakagawa, Shino Mimatsu, Natsumi Sawada, Toshiyuki Sakaki, Noboru Kubodera, Maya Kamao, Naoko Tsugawa, Yoshitomo Suhara, Toshio Okano
The active form of vitamin D, 1α,25-dihydroxyvitamin D3 (1α,25D3), plays an important role in the maintenance of calcium (Ca) homeostasis, bone formation, and cell proliferation and differentiation via nuclear vitamin D receptor (VDR). It is formed by the hydroxylation of vitamin D at the 1α position by 25-hydroxyvitamin D 1α-hydroxylase (CYP27B1) in the kidney. However, Cyp27b1(-/-) mice, deficient in CYP27B1, and VDR-deficient mice (Vdr(-/-)) have not been extensively examined, particularly in a comparative framework...
January 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28008815/in-silico-analysis-of-lanostanoids-characterized-in-ganoderma-mushrooms-agaricomycetes-as-potential-ligands-of-the-vitamin-d-receptor
#19
Jorge Suarez-Medellin, Thuluz Meza-Menchaca, Joaquin Antonio Quiroz Carranza, Angel Trigos, Abraham M Vidal-Limon
The metabolism of vitamin D is a very important pathway involved in the regulation of sterols and maintenance of cell health. The physiological activity of the human hormone 1α,25-dihydroxyvitamin D3, or calcitriol, is mediated by the vitamin D receptor (VDR), an endocrine member of the nuclear receptor superfamily that inhibits cell growth and stimulates cell differentiation, suggesting a potential application in cancer chemoprevention. Since nonpolar extracts obtained from Ganoderma mushrooms have also been shown to exert an antiproliferative effect on several cancer cell lines, it was suggested that at least part of its activity might be mediated by VDR...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28001444/vitamin-d-receptor-expression-in-plasmablastic-lymphoma-and-myeloma-cells-confers-susceptibility-to-vitamin-d
#20
Duncan M Gascoyne, Linden Lyne, Hayley Spearman, Francesca M Buffa, Elizabeth J Soilleux, Alison H Banham
Plasmablastic B-cell malignancies include plasmablastic lymphoma and subsets of multiple myeloma and diffuse large B-cell lymphoma (DLBCL). These diseases can be difficult to diagnose and treat, and lack well-characterised cell line models. Here, immunophenotyping and FOXP1 expression profiling identified plasmablastic characteristics in DLBCL cell lines HLY-1 and SU-DHL-9, associated with CTNNAL1, HPGD, RORα, IGF1 and/or vitamin D receptor (VDR) transcription. We demonstrated VDR protein expression in primary plasmablastic tumour cells, and confirmed in cell lines expression of both VDR and the metabolic enzyme CYP27B1, which catalyses active vitamin D3 production...
December 21, 2016: Endocrinology
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