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D3 vitamin growth

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https://www.readbyqxmd.com/read/29682582/vitamin-d-3-protects-against-diabetic-retinopathy-by-inhibiting-high-glucose-induced-activation-of-the-ros-txnip-nlrp3-inflammasome-pathway
#1
Li Lu, Qianyi Lu, Wei Chen, Jingwen Li, Chunxia Li, Zhi Zheng
Purpose: This study aimed to evaluate the mechanisms underlying the effects of 1,25-dihydroxyvitamin D (vitamin D3 ) on diabetes-induced retinal vascular damage and retinal vascular endothelial cell apoptosis. Methods: Diabetic and control rats were randomly assigned to receive vitamin D3 or vehicle for 6 months. Additionally, human retinal microvascular endothelial cells (HRMECs) were incubated in normal or high-glucose medium with or without vitamin D3 . Morphological changes in retinal tissues and retinal vascular permeability were examined, and cellular apoptosis was detected by fluorescence staining...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29655559/associations-between-bone-and-energy-metabolism-in-cows-fed-diets-differing-in-level-of-dietary-cation-anion-difference-and-supplemented-with-cholecalciferol-or-calcidiol
#2
R M Rodney, N P Martinez, P Celi, E Block, P C Thomson, G Wijffels, D R Fraser, J E P Santos, I J Lean
Bone-derived hormones play an important role in metabolism. This study examined the hypothesis that interactions between bone and energy metabolism, particularly those involving osteocalcin, are present in dairy cattle and have feedback mechanisms over time. Associations between metabolites in blood were examined in 32 Holstein cows blocked by parity and milk yield and randomly allocated to diets containing either 0.27 mg/kg dry matter (DM) calcidiol or cholecalciferol for an anticipated intake of 3 mg/d (120,000 IU/d) at 11 kg of DM, and positive (+130 mEq/kg DM) or negative (-130 mEq/kg DM) dietary cation-anion difference (DCAD) from 252 d of gestation to calving...
April 11, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29617899/in-ovo-applications-in-poultry-a-review
#3
E D Peebles
The various methods employed for the in ovo administration of different materials for promoting the health and productivity of poultry are discussed in this review article. The amnion has proven to be an effective site for injection and the timing of in ovo injection has commonly occurred at transfer. However, the volumes and dosages or concentrations of the materials administered vary depending on bird type, egg size, timing and site of injection, incubation system and regimen, and the type of material. Both manual and automated injections have been shown to be effective...
March 28, 2018: Poultry Science
https://www.readbyqxmd.com/read/29604361/the-vitamin-d-receptor-regulates-mir-140-5p-and-targets-the-mapk-pathway-in-bone-development
#4
Wenting Luo, Lingli Liu, Liping Yang, Yaping Dong, Tianjing Liu, Xiaowei Wei, Dan Liu, Gu Hui, Juan Kong, Zhengwei Yuan, Qun Zhao
BACKGROUND: Skeletal development is a complicated process. The status of vitamin D (VD) is closely related to fetal bone development in the embryonic period. Recently, miRNAs have been found to participate in the regulation of skeletal growth and development in several species. However, the mechanisms underlying the interactions among vitamin D, its receptor (VDR), and miRNAs during the process of bone development remain unclear. The aim of this study was to identify miRNAs that are regulated by 1,25(OH)2 D3 in murine osteoblasts and to analyze the relationship and the effects of VD/VDR and miRNAs in vitro and in vivo...
March 28, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29602956/effects-of-vitamin-d-supplementation-on-fgf23-a-randomized-controlled-trial
#5
Christian Trummer, Verena Schwetz, Marlene Pandis, Martin R Grübler, Nicolas Verheyen, Martin Gaksch, Armin Zittermann, Winfried März, Felix Aberer, Julia Steinkellner, Claudia Friedl, Vincent Brandenburg, Jakob Voelkl, Ioana Alesutan, Barbara Obermayer-Pietsch, Thomas R Pieber, Andreas Tomaschitz, Stefan Pilz
PURPOSE: Fibroblast growth factor-23 (FGF23) is critical for phosphate homeostasis. Considering the high prevalence of vitamin D deficiency and the association of FGF23 with adverse outcomes, we investigated effects of vitamin D3 supplementation on FGF23 concentrations. METHODS: This is a post-hoc analysis of the Styrian Vitamin D Hypertension trial, a single-center, double-blind, randomized, placebo-controlled trial, conducted from 2011 to 2014 at the Medical University of Graz, Austria...
March 30, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29581858/depleting-ovarian-cancer-stem-cells-with-calcitriol
#6
Amit Kumar Srivastava, Asim Rizvi, Tiantian Cui, Chunhua Han, Ananya Banerjee, Imrana Naseem, Yanfang Zheng, Altaf A Wani, Qi-En Wang
Cancer stem cells (CSCs) represent the root of many solid tumors including ovarian cancer. Eradication of CSCs represents a novel cancer therapeutic strategy. Calcitriol, also known as 1,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ], is an active metabolite of vitamin D, functioning as a potent steroid hormone. Calcitriol has shown anti-tumor effects in various cancers by regulating multiple signaling pathways. It has been reported that calcitriol can regulate the properties of normal and CSCs. However, the effect of calcitriol on the ovarian cancer growth and ovarian CSCs is still unclear...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29556928/identification-of-vitamin-d3-oxidation-products-using-high-resolution-and-tandem-mass-spectrometry
#7
Fatemeh Mahmoodani, Conrad O Perera, Grant Abernethy, Bruno Fedrizzi, David Greenwood, Hong Chen
In a successful fortification program, the stability of micronutrients added to the food is one of the most important factors. The added vitamin D3 is known to sometimes decline during storage of fortified milks, and oxidation through fatty acid lipoxidation could be suspected as the likely cause. Identification of vitamin D3 oxidation products (VDOPs) in natural foods is a challenge due to the low amount of their contents and their possible transformation to other compounds during analysis. The main objective of this study was to find a method to extract VDOPs in simulated whole milk powder and to identify these products using LTQ-ion trap, Q-Exactive Orbitrap and triple quadrupole mass spectrometry...
March 19, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29535889/effects-of-1-25-dihydroxyvitamin-d-3-on-the-differentiation-of-mc3t3-e1-osteoblast-like-cells
#8
Hyun-Soo Kim, Mingzhen Zheng, Do-Kyung Kim, Won-Pyo Lee, Sang-Joun Yu, Byung-Ock Kim
Purpose: The purpose of this study was to evaluate the effects of 1,25-dihydroxyvitamin D3 on the proliferation, differentiation, and matrix mineralization of MC3T3-E1 osteoblast-like cells in vitro. Methods: MC3T3-E1 osteoblastic cells and 1,25-dihydroxyvitamin D3 were prepared. Cytotoxic effects and osteogenic differentiation were evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, alkaline phosphatase (ALP) activity assay, ALP staining, alizarin red S staining, and reverse transcription-polymerase chain reaction (RT-PCR) for osteogenic differentiation markers such as ALP, collagen type I (Col-I), osteocalcin (OCN), vitamin D receptor (VDR), and glyceraldehyde 3-phosphate dehydrogenase...
February 2018: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29527916/the-influence-of-testosterone-on-the-expression-and-function-of-vitamin-d3-receptor-vdr-protein-in-the-porcine-ovarian-follicle
#9
M Herian, M R Luck, M Grzesiak
Recently it has been shown that vitamin D(3) acting via its cognate receptor (VDR) regulates the growth, differentiation and function of female reproductive tissues including ovary. The aim of the study was to examine the effect of testosterone (T) and its antagonist 2-hydroxyflutamide (HF) on VDR protein expression and function in porcine ovarian follicles. Medium size antral follicles expressing great amount of androgen receptors and represent high steroidogenic activity were used in this research. After 6 h incubation of whole follicles with T, HF or T+HF, immunohistochemical analysis of VDR revealed its nuclear localization in granulosa and theca interna cells in control and experimental groups...
March 12, 2018: Physiological Research
https://www.readbyqxmd.com/read/29518319/further-developments-of-the-phenyl-pyrrolyl-pentane-series-of-non-steroidal-vitamin-d-receptor-modulators-as-anticancer-agents
#10
Meixi Hao, Siyuan Hou, Lingjing Xue, Haoliang Yuan, Lulu Zhu, Cong Wang, Bin Wang, Chunming Tang, Can Zhang
Vitamin D3 receptor (VDR), belonging to the nuclear receptor superfamily, is a potential molecular target for anticancer drug discovery. In this study, a series of non-steroidal vitamin D analogs with phenyl-pyrrolyl pentane skeleton were synthesized with therapeutic potential for cancer treatment. Among them, 11b and 11g were identified as the most effective agents in reducing the viability of four cancer cell lines, particularly breast cancer cells, with IC50 values in the submicromolar concentration range...
March 8, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29483386/protection-effect-of-exogenous-fibroblast-growth-factor-21-on-the-kidney-injury-in-vascular-calcification-rats
#11
Yu-Chen Shi, Wei-Wei Lu, Yue-Long Hou, Kun Fu, Feng Gan, Shu-Juan Cheng, Shao-Ping Wang, Yong-Fen Qi, Jing-Hua Liu
Background: Chronic kidney disease (CKD) is closely related to the cardiovascular events in vascular calcification (VC). However, little has known about the characteristics of kidney injury caused by VC. Fibroblast growth factor 21 (FGF21) is an endocrine factor, which takes part in various metabolic actions with the potential to alleviate metabolic disorder diseases. Even FGF21 has been regarded as a biomarker in CKD, the role of FGF21 in CKD remains unclear. Therefore, in this study, we evaluate the FGF21 on the kidney injury in VC rats...
March 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29480024/dose-escalation-of-vitamin-d-3-yields-similar-cryosurgical-outcome-to-single-dose-exposure-in-a-prostate-cancer-model
#12
Kimberly L Santucci, John M Baust, Kristi K Snyder, Robert G Van Buskirk, John G Baust
Vitamin D3 (VD3 ) is an effective adjunctive agent, enhancing the destructive effects of freezing in prostate cancer cryoablation studies. We investigated whether dose escalation of VD3 over several weeks, to model the increase in physiological VD3 levels if an oral supplement were prescribed, would be as or more effective than a single treatment 1 to 2 days prior to freezing. PC-3 cells in log phase growth to model aggressive, highly metabolically active prostate cancer were exposed to a gradually increasing dose of VD3 to a final dose of 80 nM over a 4-week period, maintained for 2 weeks at 80 nM, and then exposed to mild sublethal freezing temperatures...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29465564/dental-caries-and-vitamin-d3-in-children-with-growth-hormone-deficiency-a-strobe-compliant-study
#13
Dorota Wójcik, Aleksandra Krzewska, Leszek Szalewski, Elżbieta Pietryka-Michałowska, Magdalena Szalewska, Szymon Krzewski, Elżbieta Pels, Iwona Beń-Skowronek
Vitamin D may prevent dental caries. To date, no attempts have been made to examine the correlation between the incidence of caries and the concentrations of vitamin D in children with pituitary growth hormone deficiency.The study observed patients of the Department of Endocrinology and Diabetology of the University Paediatric Hospital of the Medical University of Lublin treated with human recombinant growth hormone for pituitary growth hormone deficiency (GHD). The study was conducted between October 2014 and June 2015...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29452375/1%C3%AE-hydroxycholecalciferol-improves-the-growth-performance-and-up-regulates-the-mrna-expression-of-vitamin-d-receptor-in-the-small-intestine-and-kidney-of-broiler-chickens
#14
J C Han, J G Wang, G H Chen, J L Zhang, N Zhang, H X Qu, Y Guo, Y F Yan, X J Yang
1α-Hydroxycholecalciferol (1α-OH-D3) is a vitamin D derivative. The objective of this study was to evaluate the effects of 1α-OH-D3 on the growth and the mRNA expression of vitamin D receptor (VDR) in the small intestine and kidney of chickens. A total of 240 males of one-day-old Ross 308 broilers was randomly assigned to 4 treatments with 5 replicates of 12 birds per replicate. Three levels of 1α-OH-D3 (1.25, 2.5, and 5 μg/kg) were added to a basal diet containing 0.50% calcium (Ca), 0.25% non-phytate phosphorus (NPP), and without supplemental cholecalciferol (vitamin D3)...
February 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29421032/producing-functional-recombinant-human-keratinocyte-growth-factor-in-pichia-pastoris-and-investigating-its-protective-role-against-irradiation
#15
Zahra Bahadori, Hamid Reza Kalhor, Seyed Javad Mowla
Keratinocyte Growth Factor (KGF) is a paracrine-acting, epithelial mitogen that plays a prominent role in the regeneration of damaged epithelial tissues. In spite of different attempts to produce recombinant human KGF in many organisms, including bacteria, mammalian cells, plant cells and insect cells; production of recombinant form suffers from lower yields and recovery relative to other recombinant proteins of similar size and properties. Due to many advantages of Pichia pastoris expression systems for producing industrial enzymes and pharmaceutical proteins, in this study P...
April 2018: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/29401596/prostaglandin-e-2-suppresses-hcap18-ll-37-expression-in-human-macrophages-via-ep2-ep4-implications-for-treatment-of-mycobacterium-tuberculosis-infection
#16
Min Wan, Xiao Tang, Rokeya Sultana Rekha, S S V Jagadeeswara Rao Muvva, Susanna Brighenti, Birgitta Agerberth, Jesper Z Haeggström
Prostaglandin (PG)E2 is an arachidonic acid-derived lipid mediator that plays an important role in inflammation and immunity. In this study, we demonstrate that PGE2 suppresses basal and 1,25-dihydroxy vitamin D3 (VD3 )-induced expression of hCAP18/LL-37 via E prostanoid (EP)2 and EP4 receptors. In humans, VD3 up-regulates vitamin D receptor (VDR) expression and promotes transcription of the cathelicidin hCAP18/LL-37 gene, whereas PGE2 counteracts this effect. We find that PGE2 induces the cAMP/PKA-signaling pathway and enhances the expression of the inhibitory transcription factor cAMP-responsive modulator/inducible cAMP early repressor, which prevents VDR expression and induction of hCAP18/LL-37 in human macrophages...
January 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29375203/antifibrogenic-effects-of-vitamin-d-derivatives-on-mouse-pancreatic-stellate-cells
#17
Peter Wallbaum, Sarah Rohde, Luise Ehlers, Falko Lange, Alexander Hohn, Carina Bergner, Sarah Marie Schwarzenböck, Bernd Joachim Krause, Robert Jaster
AIM: To study the molecular effects of three different D-vitamins, vitamin D2, vitamin D3 and calcipotriol, in pancreatic stellate cells (PSCs). METHODS: Quiescent PSCs were isolated from mouse pancreas and activated in vitro by seeding on plastic surfaces. The cells were exposed to D-vitamins as primary cultures (early-activated PSCs) and upon re-culturing (fully-activated cells). Exhibition of vitamin A-containing lipid droplets was visualized by oil-red staining...
January 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29342138/%C3%AE-klotho-is-a-non-enzymatic-molecular-scaffold-for-fgf23-hormone-signalling
#18
Gaozhi Chen, Yang Liu, Regina Goetz, Lili Fu, Seetharaman Jayaraman, Ming-Chang Hu, Orson W Moe, Guang Liang, Xiaokun Li, Moosa Mohammadi
The ageing suppressor α-klotho binds to the fibroblast growth factor receptor (FGFR). This commits FGFR to respond to FGF23, a key hormone in the regulation of mineral ion and vitamin D homeostasis. The role and mechanism of this co-receptor are unknown. Here we present the atomic structure of a 1:1:1 ternary complex that consists of the shed extracellular domain of α-klotho, the FGFR1c ligand-binding domain, and FGF23. In this complex, α-klotho simultaneously tethers FGFR1c by its D3 domain and FGF23 by its C-terminal tail, thus implementing FGF23-FGFR1c proximity and conferring stability...
January 17, 2018: Nature
https://www.readbyqxmd.com/read/29273504/fibroblast-growth-factor-21-ameliorates-vascular-calcification-by-inhibiting-osteogenic-transition-in-vitamin-d3-plus-nicotine-treated-rats
#19
Yuchen Shi, Weiwei Lu, Yuelong Hou, Kun Fu, Feng Gan, Jinghua Liu
FGF21, a special member of FGF superfamily, has been proven to have pleiotropic metabolic effects and many potential therapeutic action in various metabolic disorders. Vascular calcification (VC), a perplexing clinical issue, is a major risk factor for many cardiovascular diseases, especially for patients with some metabolic diseases. However, the role of FGF21 on VC in vivo remains unclear. Thus, in this study, we observed the effect and mechanism of FGF21 on VC induced by vitamin D3 plus nicotine (VDN) treated rats...
January 22, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29233620/regulation-of-extracellular-matrix-vesicles-via-rapid-responses-to-steroid-hormones-during-endochondral-bone-formation
#20
REVIEW
Niels Asmussen, Zhao Lin, Michael J McClure, Zvi Schwartz, Barbara D Boyan
Endochondral bone formation is a precise and highly ordered process whose exact regulatory framework is still being elucidated. Multiple regulatory pathways are known to be involved. In some cases, regulation impacts gene expression, resulting in changes in chondrocyte phenotypic expression and extracellular matrix synthesis. Rapid regulatory mechanisms are also involved, resulting in release of enzymes, factors and micro RNAs stored in extracellular matrisomes called matrix vesicles. Vitamin D metabolites modulate endochondral development via both genomic and rapid membrane-associated signaling pathways...
December 9, 2017: Steroids
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