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https://www.readbyqxmd.com/read/28432332/involvement-of-gonadotropin-inhibitory-hormone-in-pubertal-disorders-induced-by-thyroid-status
#1
Mika Kiyohara, You Lee Son, Kazuyoshi Tsutsui
Thyroid disorders cause abnormal puberty, indicating interactions between the hypothalamus-pituitary-thyroid (HPT) and hypothalamus-pituitary-gonadal (HPG) axes, which are important in pubertal development. The hypothalamic gonadotropin-inhibitory hormone (GnIH) was shown to be decreased in the early prepubertal stage, suggesting the role of GnIH on pubertal onset. Here, we investigated whether thyroid dysfunction affects pubertal onset in female mice via GnIH regulation. Hypothyroidism showed delayed pubertal onset with increased GnIH expression and reduced pituitary-gonadal activity...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28427900/molecular-cloning-and-characterization-of-kiss1-in-brandt-s-voles-lasiopodomys-brandtii
#2
Yan Chen, Lan Liu, Zhengguang Li, Dawei Wang, Ning Li, Ying Song, Cong Guo, Xiaohui Liu
Kisspeptin, encoded by kiss1, has been regarded as a major modulator of mammalian puberty and fertility due to its stimulation on GnRH. Brandt's vole is one of the main pest species on the Inner Mongolian steppes for its striking reproductive capacity and kiss1 is a key candidate gene related to reproductive regulatory cascades. In this study, kiss1 cDNA was cloned from the hypothalamus of Brandt's voles and kiss1 mRNA levels were investigated in different tissues, and at different developmental stages, using high-throughput real-time PCR...
April 18, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28410519/in-utero-exposure-to-atrazine-analytes-and-early-menarche-in-the-avon-longitudinal-study-of-parents-and-children-cohort
#3
Gonza Namulanda, Ethel Taylor, Mildred Maisonet, Dana Boyd Barr, W Dana Flanders, David Olson, Judith R Qualters, John Vena, Kate Northstone, Luke Naeher
BACKGROUND: Evidence from experimental studies suggests that atrazine and its analytes alter the timing of puberty in laboratory animals. Such associations have not been investigated in humans. OBJECTIVE: To determine the association between in utero exposure to atrazine analytes and earlier menarche attainment in a nested case-control study of the population-based Avon Longitudinal Study of Parents and Children. METHODS: Cases were girls who reported menarche before 11...
April 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/28409310/asymmetries-and-symmetries-in-the-mouse-oocyte-and-zygote
#4
Agathe Chaigne, Marie-Emilie Terret, Marie-Hélène Verlhac
Mammalian oocytes grow periodically after puberty thanks to the dialogue with their niche in the follicle. This communication between somatic and germ cells promotes the accumulation, inside the oocyte, of maternal RNAs, proteins and other molecules that will sustain the two gamete divisions and early embryo development up to its implantation. In order to preserve their stock of maternal products, oocytes from all species divide twice minimizing the volume of their daughter cells to their own benefit. For this, they undergo asymmetric divisions in size where one main objective is to locate the division spindle with its chromosomes off-centred...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28408413/distinct-physiological-maturation-of-parvalbumin-positive-neuron-subtypes-in-mouse-prefrontal-cortex
#5
Takeaki Miyamae, Kehui Chen, David A Lewis, Guillermo Gonzalez Burgos
Parvalbumin-positive (PV(+)) neurons control the timing of pyramidal cell output in cortical neuron networks. In the prefrontal cortex (PFC), PV(+) neuron activity is involved in cognitive function, suggesting that PV(+) neuron maturation is critical for cognitive development. The two major PV(+) neuron subtypes found in the PFC, chandelier (ChCs) and basket cells (BCs), are thought to play different roles in cortical circuits, but the trajectories of their physiological maturation have not been compared. Using two separate mouse lines, we found that in the mature PFC both ChCs and BCs are abundant in the superficial layer 2, but only BCs are present in deeper laminar locations...
April 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28407861/influence-of-different-types-of-lamps-on-the-reproductive-development-of-male-japanese-quail-coturnix-coturnix-japonica
#6
Pâmela L Retes, Marcelo Espósito, Danusa G das Neves, Arabela G A Viana, Louise M Coelho, Manuel F Bobadilla-Mendez, Renata R Alvarenga, Edison J Fassani, Juliano V Peixoto, Márcio G Zangeronimo
Reproductive tract development during puberty is critical to reproductive performance, and the light is crucial in this process in birds. However, in male quail, there is little information on the effects of types of lamps, more specifically the wavelength emitted. Thus, the objective was to evaluate the effects of types of lamps on the reproductive performance of male Japanese quail (Coturnix coturnix japonica). Two hundred and forty male quail were exposed to six different types of lamp (incandescent, white fluorescent, or blue, white, red or green LED)...
May 2017: Theriogenology
https://www.readbyqxmd.com/read/28400459/investigating-the-relationship-between-precocious-puberty-and-obesity-a-cross-sectional-study-in-shanghai-china
#7
Chang Chen, Yunting Zhang, Wanqi Sun, Yao Chen, Yanrui Jiang, Yuanjin Song, Qinmin Lin, Lixia Zhu, Qi Zhu, Xiumin Wang, Shijian Liu, Fan Jiang
OBJECTIVES: Obesity is reported to be closely relevant to early sexual development but the relationship between sexual precocity and obesity or central obesity is still inconsistent, especially in boys. We aimed to investigate the relationship between precocious puberty and obesity as well as central obesity. DESIGN: A large population-based cross-sectional study using multistage, stratified cluster random sampling. SETTING: Data from the Shanghai Children's Health, Education and Lifestyle Evaluation (SCHEDULE) study in June 2014...
April 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28397629/the-impact-of-life-stress-on-adult-depression-and-anxiety-is-dependent-on-gender-and-timing-of-exposure
#8
Carly E Herbison, Karina Allen, Monique Robinson, John Newnham, Craig Pennell
There is debate about the relative importance of timing of stressful events prenatally and over the life course and risk for subsequent depressive/anxious illness. The aim of this study was to examine the relative roles of prenatal stress and postnatal stress trajectories in predicting depression and anxiety in early adulthood in males and females. Exposure to life stress events was examined in the Western Australian Pregnancy Cohort (Raine) Study during pregnancy and ages 1, 2, 3, 5, 8, 10, 14, and 17 years...
April 11, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28397355/sex-differences-in-athletic-performance-emerge-coinciding-with-the-onset-of-male-puberty
#9
David J Handelsman
BACKGROUND: Male performance in athletic events begins to exceed that of age-matched females during early adolescence but the timing of this divergence relative to the onset of male puberty and the rise of circulating testosterone remains poorly defined. DESIGN: This study is a secondary quantitative analysis of four published sources which aimed to define the timing of the gender divergence in athletic performance and relating it to the rise in circulating testosterone due to male puberty...
April 11, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28390864/an-acute-social-defeat-stressor-in-early-puberty-increases-susceptibility-to-social-defeat-in-adulthood
#10
Anna M Rosenhauer, Katharine E McCann, Alisa Norvelle, Kim L Huhman
Syrian hamsters readily display territorial aggression; if they lose even a single agonistic encounter, however, hamsters show striking reductions in aggressive behavior and increases in submissive behavior, a distinct behavioral change that we have previously termed conditioned defeat. This acute social defeat stressor is primarily psychological and is effective in both males and females. Therefore, we maintain that this procedure presents an ideal model for studying behavioral and physiological responses to social stress...
April 5, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28383228/classic-congenital-adrenal-hyperplasia
#11
Ingrid Nermoen, Eystein S Husebye, Anne Grethe Myhre, Kristian Løvås
Congenital adrenal hyperplasia is attributed to inherited enzyme defects in the adrenal cortex. The classical form results in reduced production of cortisol and aldosterone, accompanied by an increase in production of adrenal cortical androgens. This causes virilisation in girls, adrenocortical failure and early puberty in both sexes. This article describes the genetics, clinical picture, diagnostics and treatment.
April 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/28378787/from-lark-to-owl-developmental-changes-in-morningness-eveningness-from-new-borns-to-early-adulthood
#12
Christoph Randler, Corina Faßl, Nadine Kalb
Morningness-eveningness or chronotype changes significantly throughout the life span. This has been reported for the transition during adolescence in some studies, and to a lesser extent in early adulthood. Primary and pre-school children have been under investigation in fewer studies. This is the first comprehensive study covering the age range from very young children until early adulthood (0-30 years) based on the same measurement instrument. Here, we show that the turn towards eveningness starts at an early age in German children...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28372865/left-ventricular-morphology-and-function-in-adolescents-relations-to-fitness-and-fatness
#13
Katrin A Dias, Angela L Spence, Satyam Sarma, David Oxborough, Anita S Timilsina, Peter S W Davies, Peter A Cain, Gary M Leong, Charlotte B Ingul, Jeff S Coombes
BACKGROUND: Obesity in childhood predisposes individuals to cardiovascular disease and increased risk of premature all-cause mortality. The aim of this study was to determine differences in LV morphology and function in obese and normal-weight adolescents. Furthermore, relationships between LV outcomes, cardiorespiratory fitness (CRF) and adiposity were explored. METHODS: LV morphology was assessed using magnetic resonance imaging (MRI) in 20 adolescents (11 normal-weight [BMI equivalent to 18kg/m(2)-25kg/m(2)] and 9 obese [BMI equivalent to ≥30kg/m(2)]); 13...
March 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28364296/juvenile-onset-myasthenia-gravis-autoantibody-status-clinical-characteristics-and-genetic-polymorphisms
#14
Yu Hong, Geir Olve Skeie, Paraskevi Zisimopoulou, Katerina Karagiorgou, Socrates J Tzartos, Xiang Gao, Yao-Xian Yue, Fredrik Romi, Xu Zhang, Hai-Feng Li, Nils Erik Gilhus
Myasthenia gravis (MG) is an autoimmune disorder mediated by antibodies against proteins at the neuromuscular junction. Juvenile-onset MG (JMG) has been reported to have special characteristics. It is still unclear whether there are any pathogenic and genetic differences between juvenile and adult MG. In this study, we evaluated the clinical characteristics, autoantibody status (antibodies against AChR, MuSK, LRP4, titin and RyR) and genetic susceptibility (CHRNA1, CTLA4 and AIRE) in 114 Chinese JMG patients, and compared with 207 young adult MG patients (onset age 18-40 years)...
March 31, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28364286/adult-height-after-spontaneous-pubertal-growth-or-gnrh-analog-treatment-in-girls-with-early-puberty-a-meta-analysis
#15
Silvano Bertelloni, Francesco Massart, Mario Miccoli, Giampiero I Baroncelli
Early puberty (EP) has been defined as the onset of puberty in the low-normal range; it may be a cause for concern regarding a possible impairment of adult height (AH). This paper meta-analysed data on AH after spontaneous growth or after gonadotropin-releasing hormone (GnRH) analog treatment in girls with EP. A computerized literature search was conducted from 1980 to June 30, 2016. Only published studies in English were considered. Eight papers were selected (483 cases). In untreated girls (n = 300), predicted adult height (PAH) at start of follow-up (-0...
April 1, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28364254/characterisation-of-rapid-progressors-to-type-1-diabetes-among-children-with-hla-conferred-disease-susceptibility
#16
Petra M Pöllänen, Johanna Lempainen, Antti-Pekka Laine, Jorma Toppari, Riitta Veijola, Paula Vähäsalo, Jorma Ilonen, Heli Siljander, Mikael Knip
AIMS/HYPOTHESIS: In this study, we aimed to characterise rapid progressors to type 1 diabetes among children recruited from the general population, on the basis of HLA-conferred disease susceptibility. METHODS: We monitored 7410 HLA-predisposed children participating in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study for the development of beta cell autoimmunity and type 1 diabetes from birth over a median follow-up time of 16.2 years (range 0...
March 31, 2017: Diabetologia
https://www.readbyqxmd.com/read/28351649/frequency-of-gonadal-tumours-in-complete-androgen-insensitivity-syndrome-cais-a-retrospective-case-series-analysis
#17
S Chaudhry, R Tadokoro-Cuccaro, S E Hannema, C L Acerini, I A Hughes
BACKGROUND: Complete androgen insensitivity syndrome (CAIS) is an X-linked recessive disorder of sex development (DSD) where affected individuals are phenotypically female, but have an XY karyotype and testes. The risk of gonadal tumour development in CAIS may increase with age; incidence rates have been reported to be 0.8-22% in patients who have retained their gonads into adulthood. Consequently, gonadectomy has been recommended either during childhood or after puberty is complete, although there is no consensus on the optimal timing for this procedure...
March 14, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28348072/the-follicle-stimulating-hormone-fsh-and-luteinizing-hormone-lh-response-to-a-gonadotropin-releasing-hormone-analogue-test-in-healthy-prepubertal-girls-aged-10-months-to-6-years
#18
Esben Thyssen Vestergaard, Mia Elbek Schjørring, Konstantinos Kamperis, Karin Kastberg Petersen, Søren Rittig, Anders Juul, Kurt Kritstensen, Niels Birkebæk
OBJECTIVE: Premature thelarche and precocious puberty are frequently diagnosed in girls even below 6 years of age and may be difficult to differentiate in the early stages. A GnRH test is often included in the diagnostic work-up, although interpretation of the GnRH test in girls below 6 years of age is challenging, as no reference interval exists for this age group. The objective is to determine the normal FSH and LH response to a GnRH test in healthy prepubertal girls below 6 years of age...
March 27, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28346917/endocrine-long-term-follow-up-of-children-with-neurofibromatosis-type-1-and-optic-pathway-glioma%C3%A2
#19
Ilaria Sani, Assunta Albanese
BACKGROUND/AIMS: Children with optic pathway glioma (OPG) face sequelae related to tumour location and treatment modalities. We aimed to assess the prevalence of hypothalamic-pituitary dysfunctions in children with neurofibromatosis type 1 (NF1) and OPG who did not receive radiotherapy or surgical resection. The causative role of tumour location on endocrinopathy development is investigated. METHODS: A retrospective follow-up study of 40 children with NF1 and OPG evaluated between August 1996 and May 2015 was undertaken...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28344041/stat5-signaling-in-kisspeptin-cells-regulates-the-timing-of-puberty
#20
Marina Augusto Silveira, Isadora C Furigo, Thais T Zampieri, Tabata M Bohlen, Daniella G de Paula, Celso Rodrigues Franci, Jose Donato, Renata Frazao
Previous studies have shown that kisspeptin neurons are important mediators of prolactin's effects on reproduction. However, the cellular mechanisms recruited by prolactin to affect kisspeptin neurons remain unknown. Using whole-cell patch-clamp recordings of brain slices from kisspeptin reporter mice, we observed that 20% of kisspeptin neurons in the anteroventral periventricular nucleus was indirectly depolarized by prolactin via an unknown population of prolactin responsive neurons. This effect required the phosphatidylinositol 3-kinase signaling pathway...
March 23, 2017: Molecular and Cellular Endocrinology
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