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https://www.readbyqxmd.com/read/28065683/cutaneous-features-of-myotonic-dystrophy-types-1-and-2-implication-of-premature-aging-and-vitamin-d-homeostasis
#1
Elena Campione, Annalisa Botta, Monia Di Prete, Emanuele Rastelli, Manuela Gibellini, Antonio Petrucci, Sergio Bernardini, Giuseppe Novelli, Luca Bianchi, Augusto Orlandi, Roberto Massa, Chiara Terracciano
Skin changes have been described in myotonic dystrophy type 1 (DM1). However, whether and in which way skin is a target of specific disease alterations in DM1 and DM2 has not been yet clarified. This study aims to explore cutaneous features of DM1 and DM2 patients. Skin examination was performed in 60 DM1, 15 DM2, and 103 control, unselected patients by means of dermoscopy. It revealed quantitative and qualitative abnormalities of nevi and typical signs of premature aging in both DM1 and DM2 patients, with a significantly higher frequency of dysplastic nevi, alopecia, xerosis and seborrheic dermatitis...
November 16, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28052277/unknown-primary-melanoma-worldwide-survey-on-clinical-management
#2
Simone Ribero, Riccardo Pampena, Veronique Bataille, Elvira Moscarella, Luc Thomas, Pietro Quaglino, Concetta Potenza, Alexander C J Van Akkooi, Alessandro Testori, Paul Nathan, Susana Puig, Iris Zalaudek, Giuseppe Argenziano, Caterina Longo
BACKGROUND: How to deal with melanoma of unknown primary (MUP) origin is a debated topic in the literature. OBJECTIVE: We performed a worldwide survey to inquire what clinical and investigational workup is performed as well as the physicians' perception of this disease. METHODS: A questionnaire was sent via mail to clinicians involved in melanoma care from December 2015 to April 2016 using the International Dermoscopy Society website. RESULTS: 119 physicians from 47 different countries answered the questionnaire...
January 5, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28035218/melanoma-awareness-and-prevalence-of-dermoscopic-examination-among-internet-users-a-cross-sectional-survey
#3
Grazyna Kaminska-Winciorek, Jerzy Wydmanski, Maksymilian Gajda, Andrzej Tukiendorf
INTRODUCTION: Melanoma presents the greater threat to health the later the disease is detected and treated, although treatment results can be improved by the widespread use of dermoscopy. However, scarce data are available concerning the awareness of dermoscopy and the frequency of its performance in the non-patient population. AIM: To assess the awareness of melanoma detection by dermoscopic examination among the audience of a scientific website. MATERIAL AND METHODS: Respondents were invited to participate in an online cross-sectional survey...
December 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28030717/pathologic-evaluation-of-skin-tumors-with-ex-vivo-dermoscopy-with-derm-dotting
#4
Marc Haspeslagh, Isabelle Hoorens, Nele Degryse, Ine De Wispelaere, Annemarie Degroote, Sarah Van Belle, Jan Verboven, Katrien Vossaert, Fabio Facchetti, Jo Van Dorpe, Sofie De Schepper, Lieve Brochez
Importance: Ex vivo dermoscopy (EVD) with derm dotting (DD) improves clinicopathologic correlation and the quality of diagnosis in skin tumors. Objective: To compare the diagnostic performance of the standard method of skin biopsy processing with the practice of EVD with DD. Design, Setting, and Participants: This retrospective study compares the diagnostic performance in 6526 skin biopsy specimens examined from 2008 to 2010 with a standard method of processing with 8584 biopsy specimens examined in 2015 with EVD and DD...
December 28, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/28026754/automated-melanoma-recognition-in-dermoscopy-images-via-very-deep-residual-networks
#5
Lequan Yu, Hao Chen, Qi Dou, Jing Qin, Pheng Ann Heng
Automated melanoma recognition in dermoscopy images is a very challenging task due to the low contrast of skin lesions, the huge intraclass variation of melanomas, the high degree of visual similarity between melanoma and non-melanoma lesions, and the existence of many artifacts in the image. In order to meet these challenges, we propose a novel method for melanoma recognition by leveraging very deep convolutional neural networks (CNNs). Compared with existing methods employing either low-level hand-crafted features or CNNs with shallower architectures, our substantially deeper networks (more than 50 layers) can acquire richer and more discriminative features for more accurate recognition...
December 21, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27996145/integrating-clinical-information-dermoscopy-and-reflectance-confocal-microscopy-to-improve-the-diagnostic-accuracy-and-confidence-of-amelanotic-and-lightly-pigmented-melanomas
#6
https://www.readbyqxmd.com/read/27913337/melanoma-classification-on-dermoscopy-images-using-a-neural-network-ensemble-model
#7
Feng-Ying Xie, Haidi Fan, Li Yang, Zhi-Guo Jiang, Ru-Song Meng, Alan Bovik
We develop a novel method for classifying melanocytic tumors as benign or malignant by the analysis of digital dermoscopy images. The algorithm follows three steps: first, lesions are extracted using a self-generating neural network (SGNN); second, features descriptive of tumor color, texture and border are extracted; and third, lesion objects are classified using a classifier based on a neural network ensemble model. In clinical situations, lesions occur that are too large to be entirely contained within the dermoscopy image...
December 1, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27892649/thresholding-methods-for-lesion-segmentation-of-basal-cell-carcinoma-in-dermoscopy-images
#8
R Kaur, R LeAnder, N K Mishra, J R Hagerty, R Kasmi, R J Stanley, M E Celebi, W V Stoecker
PURPOSE: Algorithms employed for pigmented lesion segmentation perform poorly on dermoscopy images of basal cell carcinoma (BCC), the most common skin cancer. The main objective was to develop better methods for BCC segmentation. METHODS: Fifteen thresholding methods were implemented for BCC lesion segmentation. We propose two error metrics that better measure the type II error: Relative XOR Error and Lesion Capture Ratio. RESULTS: On training/test sets of 305 and 34 BCC images, respectively, five new techniques outperform two state-of-the-art methods used in segmentation of melanomas, based on the new error metrics...
November 28, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27878858/non-invasive-tools-for-the-diagnosis-of-cutaneous-melanoma
#9
REVIEW
C Fink, H A Haenssle
BACKGROUND: While the excisional biopsy and histological examination of suspicious lesions remains the current gold standard for diagnosing cutaneous melanoma (CM), there is a demand for more objective and non-invasive examination methods that may support clinicians in their decision when to biopsy or not. METHODS: This review is based on publications and guidelines retrieved by a selective search in PubMed and MEDLINE and focused on non-invasive diagnostic strategies for detecting melanoma...
November 22, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27867748/pigmented-bowen-s-disease-presenting-with-a-starburst-pattern
#10
Vincenzo Maione, Enzo Errichetti, Sara Laurent Roussel, Celeste Lebbé
Pigmented Bowen's disease (pBD) is an uncommon in situ squamous cell carcinoma of the skin usually presenting as a dark scaly plaque involving chronically exposed sites, which is not uncommonly mistaken for other similar pigmented lesions, such as melanoma, pigmented basal cell carcinoma or seborrheic keratosis [1,2]. Dermoscopy has been proven to improve its diagnosis by showing several findings, i.e., gray/brownish dots in linear arrangement, scales, coiled vessels, focal/multifocal amorphous hypopigmentation and bluish structureless areas [1,2]...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27867742/dermoscopic-appearance-of-an-amelanotic-mucosal-melanoma
#11
Andreas Blum, Ulrike Beck-Zoul, Laura Held, Sylvie Haase
BACKGROUND: Hypomelanotic or amelanotic melanomas are challenging to identify, especially at mucosal sites. The dermoscopic clues to the diagnosis of mucosal melanomas have been reported to be structureless zones with the presence of blue, gray, or white colors. CASE: A female in her seventies noted a new lesion on the inside of her right labia that first appeared two months prior. Her past medical history was significant for rheumatoid arthritis requiring ongoing treatment with methotrexate for 20 years and adalimumab for 10 years...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27867738/evaluation-of-electrical-impedance-spectroscopy-as-an-adjunct-to-dermoscopy-in-short-term-monitoring-of-atypical-melanocytic-lesions
#12
Hannah Ceder, Alexandra Sjöholm Hylén, Ann-Marie Wennberg Larkö, John Paoli
BACKGROUND: Early detection of melanoma is vital for treatment outcome and survival. Short-term sequential digital dermoscopic monitoring (ST-SDDM) involves the capture and assessment of dermoscopic images of one or more atypical melanocytic lesions (AMLs), at baseline and after four months, in order to detect early morphologic changes. Electrical impedance spectroscopy (EIS) is a diagnostic tool with high sensitivity for the detection of malignant melanocytic lesions. OBJECTIVES: The aim of this study was to assess whether EIS, in addition to ST-SDDM, could improve the selection of AMLs requiring surgery...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27860083/dermoscopic-monitoring-of-efficacy-of-ingenol-mebutate-in-the-treatment-of-pigmented-and-non-pigmented-basal-cell-carcinomas
#13
Laura Diluvio, Mauro Bavetta, Monia Di Prete, Augusto Orlandi, Luca Bianchi, Elena Campione
Basal cell carcinoma is the most common non-melanoma skin cancer, and its incidence continues to raise. Although surgery can be considered the mainstay of therapy, new current pharmacological options are available and focus on tumor eradication, maximizing cosmetic results, and functional capacity. Several studies have recently reported on safety and efficacy of topical ingenol mebutate gel, a derivative of the plant Euphorbia Peplus, used to treat actinic keratosis and superficial basal cell carcinoma. In our knowledge, we report for the first time the dermoscopic evaluation of outcome and monitoring of superficial pigmented and non-pigmented basal cell carcinomas in four patients treated by this novel non-ablative agent...
November 12, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27793452/dermoscopic-patterns-of-fungal-melanonychia-a-comparative-study-with-other-causes-of-melanonychia
#14
Jungyoon Ohn, Yun Seon Choe, Jin Park, Je-Ho Mun
BACKGROUND: Diagnosing fungal melanonychia (FM) is often difficult because it mimics melanonychia caused by other factors. Dermoscopy is helpful in the setting of nail pigmentation. However, the diagnostic characteristics of FM on dermoscopy are not fully elucidated. OBJECTIVE: We sought to determine the dermoscopic characteristics of FM. METHODS: We evaluated the dermoscopic patterns of FM diagnosed at 2 university hospitals from January 2010 to February 2016...
October 25, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27790766/association-between-dermoscopic-and-reflectance-confocal-microscopy-features-of-cutaneous-melanoma-with-braf-mutational-status
#15
C Bombonato, S Ribero, F C Pozzobon, J A Puig-Butille, C Badenas, C Carrera, J Malvehy, E Moscarella, A Lallas, S Piana, S Puig, G Argenziano, C Longo
BACKGROUND: Melanomas harbouring common genetic mutations might share certain morphological features detectable with dermoscopy and reflectance confocal microscopy. BRAF mutational status is crucial for the management of metastatic melanoma. OBJECTIVES: To correlate the dermoscopic characteristics of primary cutaneous melanomas with BRAF mutational status. Furthermore, a subset of tumours has also been analysed for the presence of possible confocal features that might be linked with BRAF status...
October 28, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27790747/two-cases-of-seborrheic-keratosis-with-basal-clear-cells
#16
Takashi Anan, Takaya Fukumoto, Tetsunori Kimura
Seborrheic keratosis with basal clear cells (SKBCC) is an extremely rare histopathological variant of seborrheic keratosis that has histological similarities to melanoma in situ. We herein report two cases of SKBCC and provide the first description of the dermoscopic features of this condition, in addition to the histopathological findings. Both of the two lesions showed typical histological architectures of seborrheic keratosis with rows or focal clusters of monomorphic clear cells with abundant pale cytoplasm and small round nucleus in the basal layer...
October 28, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27785832/tumor-regrowth-and-development-of-keratinocytic-neoplasms-in-patients-under-smoothened-inhibition-in-vivo-assessment-with-reflectance-confocal-microscopy
#17
I Alarcon, P Pasquali, J Malvehy, S Puig
BACKGROUND: The regrowth of a tumor after complete clinical response and the development of keratinocytic neoplasms while patients are still undergoing continuous vismodegib have stressed the importance of the accurate monitoring to detect recurrences earlier and ensure the best possible outcome. OBJECTIVE: The objective of this study was to determine the role of reflectance confocal microscopy (RCM) in monitoring the response of locally advanced basal cell carcinoma (laBCC) to vismodegib and to discard secondary resistance...
October 27, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27783441/digital-imaging-biomarkers-feed-machine-learning-for-melanoma-screening
#18
LETTER
Daniel S Gareau, Joel Correa da Rosa, Sarah Yagerman, John A Carucci, Nicholas Gulati, Ferran Hueto, Jennifer L DeFazio, Mayte Suárez-Fariñas, Ashfaq Marghoob, James G Krueger
We developed an automated approach for generating quantitative image analysis metrics (imaging biomarkers) that are then analysed with a set of 13 machine learning algorithms to generate an overall risk score that is called a Q-score. These methods were applied to a set of 120 "difficult" dermoscopy images of dysplastic nevi and melanomas that were subsequently excised/classified. This approach yielded 98% sensitivity and 36% specificity for melanoma detection, approaching sensitivity/specificity of expert lesion evaluation...
October 26, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27774454/computer-based-melanocytic-and-nevus-image-enhancement-and-segmentation
#19
Uzma Jamil, M Usman Akram, Shehzad Khalid, Sarmad Abbas, Kashif Saleem
Digital dermoscopy aids dermatologists in monitoring potentially cancerous skin lesions. Melanoma is the 5th common form of skin cancer that is rare but the most dangerous. Melanoma is curable if it is detected at an early stage. Automated segmentation of cancerous lesion from normal skin is the most critical yet tricky part in computerized lesion detection and classification. The effectiveness and accuracy of lesion classification are critically dependent on the quality of lesion segmentation. In this paper, we have proposed a novel approach that can automatically preprocess the image and then segment the lesion...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27766942/abrupt-skin-lesion-border-cutoff-measurement-for-malignancy-detection-in-dermoscopy-images
#20
Sertan Kaya, Mustafa Bayraktar, Sinan Kockara, Mutlu Mete, Tansel Halic, Halle E Field, Henry K Wong
BACKGROUND: Automated skin lesion border examination and analysis techniques have become an important field of research for distinguishing malignant pigmented lesions from benign lesions. An abrupt pigment pattern cutoff at the periphery of a skin lesion is one of the most important dermoscopic features for detection of neoplastic behavior. In current clinical setting, the lesion is divided into a virtual pie with eight sections. Each section is examined by a dermatologist for abrupt cutoff and scored accordingly, which can be tedious and subjective...
October 6, 2016: BMC Bioinformatics
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