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https://www.readbyqxmd.com/read/29024734/clinical-and-dermoscopic-characterization-of-pediatric-and-childhood-melanomas-multicenter-study-of-52-cases
#1
Cristina Carrera, Alon Scope, Stephen W Dusza, Giuseppe Argenziano, Gianluca Nazzaro, Alice Phan, Isabelle Tromme, Pietro Rubegni, Josep Malvehy, Susana Puig, Ashfaq A Marghoob
BACKGROUND: Knowledge regarding the morphologic spectrum of pediatric melanoma (PM) is sparse and this may in part contribute to delay in detection and thicker tumors. OBJECTIVE: to analyze the clinical-dermoscopic characteristics of PM. METHODS: retrospective study of 52 melanomas diagnosed before age of 20. RESULTS: Based on clinical, dermoscopic and histopathological characteristics, PM can be classified as Spitzoid and Non-Spitzoid Non-Spitzoid (37, 72...
October 9, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28976087/noninvasive-diagnosis-in-dermatology
#2
Julia Welzel, Sandra Schuh
In addition to dermoscopy, there are other imaging and biophysical methods for the noninvasive diagnosis of skin lesions. Confocal laser microscopy allows for high-resolution imaging of the epidermis and upper dermis. It is particularly suitable in the differential diagnosis of melanocytic lesions. Optical coherence tomography (OCT) has a lower resolution compared to confocal laser microscopy but a greater depth of penetration. It is primarily used for imaging epithelial skin cancer, especially in the context of monitoring the effectiveness of nonsurgical therapies...
October 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28969863/results-of-the-2016-international-skin-imaging-collaboration-international-symposium-on-biomedical-imaging-challenge-comparison-of-the-accuracy-of-computer-algorithms-to-dermatologists-for-the-diagnosis-of-melanoma-from-dermoscopic-images
#3
Michael A Marchetti, Noel C F Codella, Stephen W Dusza, David A Gutman, Brian Helba, Aadi Kalloo, Nabin Mishra, Cristina Carrera, M Emre Celebi, Jennifer L DeFazio, Natalia Jaimes, Ashfaq A Marghoob, Elizabeth Quigley, Alon Scope, Oriol Yélamos, Allan C Halpern
BACKGROUND: Computer vision may aid in melanoma detection. OBJECTIVE: We sought to compare melanoma diagnostic accuracy of computer algorithms to dermatologists using dermoscopic images. METHODS: We conducted a cross-sectional study using 100 randomly selected dermoscopic images (50 melanomas, 44 nevi, and 6 lentigines) from an international computer vision melanoma challenge dataset (n = 379), along with individual algorithm results from 25 teams...
September 29, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28961304/videodermoscopy-as-a-novel-tool-for-dermatologic-education
#4
Sarah L Sheu, Hyunje G Cho, Kristin M Nord
Dermoscopy is used as an adjunct to clinical examination in the diagnosis of skin lesions, including melanoma. Videodermoscopy, which allows for the concurrent examination of dermoscopic features at high magnification by instructors and trainees, may serve as a useful educational tool during bedside instruction. This article presents images of common cutaneous lesions taken with a standard optical dermatoscope and a videodermatoscope to highlight the potential educational advantages conferred by videodermoscopy...
August 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28915278/differential-diagnosis-of-seborrheic-keratosis-clinical-and-dermoscopic-features
#5
Ralph P Braun, Sabine Ludwig, Ashfaq A Marghoob
<p>Seborrheic keratosis (SK) is a benign epidermal keratinocytic tumor that is extremely common, particularly in individuals over the age of 50. Most individuals with SK will have more than one lesion and the presence of over 10 lesions in the same person is not uncommon. Although the clinical morphology of most SK with their stuck-on, symmetric, keratotic, and waxy appearance makes them easy to identify, many manifest a morphology resembling melanoma or squamous cell carcinoma. One can argue that such cases will ultimately not prove to be problematic since a simple biopsy will easily reveal their benign nature and eliminate any concerns...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28886799/mole-mapping-for-management-of-pigmented-skin-lesions
#6
REVIEW
Juliana Berk-Krauss, David Polsky, Jennifer A Stein
Identifying new or changing melanocytic lesions, particularly in patients with numerous or atypical nevi, can be challenging. Total-body photography and sequential digital dermoscopy imaging, together known as digital follow-up, are 2 prominent forms of noninvasive imaging technology used in mole mapping that have been found to improve diagnostic accuracy, detect earlier-stage melanomas, and reduce costs. Digital follow-up, in combination with direct-to-consumer applications and teledermatology, is already revolutionizing the ways in which physicians and patients participate in melanoma surveillance and will likely continue to enhance early detection efforts...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28886798/enhancing-skin-cancer-diagnosis-with-dermoscopy
#7
REVIEW
Zachary J Wolner, Oriol Yélamos, Konstantinos Liopyris, Tova Rogers, Michael A Marchetti, Ashfaq A Marghoob
Dermoscopy increases the sensitivity for skin cancer detection, decreases the number of benign lesions biopsied for each malignant diagnosis, and enables the diagnosis of thinner melanomas compared with naked eye examination. Multiple meta-analyses have identified that dermoscopy improves the diagnostic accuracy for melanoma when compared with naked eye examination. In addition, studies have established that dermoscopy can aid in the detection of keratinocyte carcinomas. Dermoscopy triage algorithms have been developed to help novices decide when a biopsy or a referral is most appropriate...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28846171/dermoscopy-and-the-diagnosis-of-primary-cutaneous-b-cell-lymphoma
#8
S Geller, A A Marghoob, A Scope, R P Braun, P L Myskowski
BACKGROUND: Primary cutaneous B-cell lymphomas (PCBCLs) are frequently misdiagnosed, and a biopsy is needed to attain the correct diagnosis. OBJECTIVE: To characterize the dermoscopic features of PCBCL. METHODS: In this retrospective observational study, we analysed the pathology reports of 172 newly diagnosed PCBCL for the initial clinical differential diagnosis. The dermoscopic images of 58 PCBCL were evaluated for dermoscopic features. Two dermoscopy experts, who were blinded to the diagnosis and the study objective, evaluated images from 17 cases for a dermoscopic differential diagnosis...
August 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28832952/optical-transfer-diagnosis-differentiating-benign-and-malignant-pigmented-lesions-in-a-simulated-primary-care-practice
#9
D L Swanson, R V Venneugues, S Q Vicencio, J Garioch, M Biryulina, G Ryzhikov, B Hamre, L Zhao, F S Castellana, K Stamnes, J J Stamnes
BACKGROUND: The detection of melanoma poses a substantial challenge, particularly for primary care providers (PCPs) who may have limited training in discriminating between suspicious and benign melanocytic lesions. The noninvasive optical transfer diagnosis (OTD) method was designed to be used by PCPs in their decision-making process. OBJECTIVES: The aim of this clinical study was to assess the potential of the OTD method by developing, training, and validating an OTD indication algorithm for automated discrimination between benign melanocytic lesions and malignant lesions, based on a set of 712 lesions...
August 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28676883/dermoscopy-confocal-microscopy-and-other-non-invasive-tools-for-the-diagnosis-of-non-melanoma-skin-cancers-and-other-skin-conditions
#10
Josep Malvehy, Giovanni Pellacani
Non-melanoma skin cancer (NMSC), including basal cell and squamous cell carcinomas, is the most common form of neoplasm. The incidence of NMSC is increasing worldwide. The cure rate is high with early detection and appropriate treatment. Visual examination is the first screening tool used by clinicians, but it is sometimes not sufficient to discriminate benign from malignant lesions. Skin biopsy with histopathology is the gold standard for differential diagnosis; however, this procedure is invasive and occasionally painful...
July 5, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28676882/dermoscopy-digital-dermoscopy-and-other-diagnostic-tools-in-the-early-detection-of-melanoma-and-follow-up-of-high-risk-skin-cancer-patients
#11
Luc Thomas, Susana Puig
Early detection is a key strategy for reducing the mortality and economic burden associated with melanoma. Dermoscopy is a non-invasive and cost-effective tool for melanoma diagnosis, which has been shown to be a reliable and sensitive method for detecting early-stage skin cancer and reducing the number of unnecessary excisions. Patients at high risk of developing melanoma require long-term surveillance. Use of digital dermoscopy follow-up of these patients has led to improved outcomes. Combined follow-up programmes using total-body photography and digital dermoscopy have led to further improvements in early diagnosis and diagnostic accuracy...
July 5, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28676880/innovations-and-developments-in-dermatologic-non-invasive-optical-imaging-and-potential-clinical-applications
#12
Eric Tkaczyk
Most dermatologists are aware of the benefits of dermoscopy, and a few are familiar with laser-scanning confocal microscopy. Beyond confocal, there are fully 11 different categories of optical techniques that have been applied to clinical dermatology. This article first provides a comprehensive tabular overview of all these optical diagnostic technologies and then details 4 of the lesser known innovations that are already available or still in development (laser Doppler and speckle imaging, Raman spectroscopy, multiphoton microscopy, photoacoustic tomography), with some potential applications in clinical dermatology (blood flow monitoring, skin cancer diagnosis, composition measurements in atopic dermatitis, skin rejuvenation measurement, and noninvasive sentinel lymph node assessment in melanoma)...
July 5, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28662904/corrigendum-to-cost-effectiveness-analysis-in-melanoma-detection-a-transition-model-applied-to-dermoscopy-eur-j-cancer-67-2016-38-45
#13
Isabelle Tromme, Catherine Legrand, Brecht Devleesschauwer, Ulrike Leiter, Stefan Suciu, Alexander Eggermont, Laurine Sacré, Jean-François Baurain, Luc Thomas, Philippe Beutels, Niko Speybroeck
No abstract text is available yet for this article.
June 26, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28658677/similar-but-different-how-reflectance-confocal-microscopy-may-help-in-the-diagnosis-of-pink-lesions
#14
Federica Ferrari, Sara Bassoli, Giovanni Pellacani, Giuseppe Argenziano, Anna Maria Cesinaro, Caterina Longo
BACKGROUND: Among skin neoplasms, solitary pink tumors represent challenging lesions in clinical practice since they can mimic melanocytic and nonmelanocytic lesions or even inflammatory ones. OBJECTIVE: In this case series we described dermoscopic and confocal features of 2 couples of similar lesions in order to achieve the correct diagnosis and the best therapeutic approach. METHODS: During clinical routine practice, 2 couples of clinically and dermoscopically similar lesions were examined by means of confocal microscopy...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28632887/pushing-the-edge-of-dermoscopy-in-new-directions-entomodermoscopy-of-trombicula-autumnalis
#15
Nicola di Meo, Mattia Fadel, Giusto Trevisan
Dermatologists are often faced with the challenge of patients presenting with non specific symptoms such as itching and or erythema. These symptoms may be attributed to a number of diseases, many of which are trivial, and others even life-threatening. In order to establish the correct diagnosis, dermatologists must rely on good diagnostic tools and knowledge. Dermoscopy was introduced mainly for inspection of pigmented lesions, but its use has now also spread to non-melanoma skin cancer, inflammatory diseases, and almost any skin disease...
June 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28573666/detection-of-desmoplastic-melanoma-with-dermoscopy-and-reflectance-confocal-microscopy
#16
N G Maher, A Solinas, R A Scolyer, S Puig, G Pellacani, P Guitera
BACKGROUND: Desmoplastic melanoma (DM) is frequently misdiagnosed clinically and often associated with melanoma in situ (MIS). OBJECTIVE: To improve the detection of DM using dermoscopy and reflectance confocal microscopy (RCM). METHODS: A descriptive analysis of DM dermoscopy features and a case-control study within a melanoma population for RCM feature evaluation was performed blindly, using data obtained between 2005 and 2015. After retrospectively identifying all DM cases with RCM data over the study period (n = 16), a control group of non-DM melanoma patients with RCM data, in a ratio of at least 3 : 1, was selected...
June 2, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28565919/age-and-anatomical-location-related-dermoscopic-patterns-of-210-acral-melanocytic-nevi-in-a-turkish-population
#17
Nazan Emiroglu, Fatma Pelin Cengiz, Nahide Onsun
BACKGROUND: Dermoscopy is a useful tool for earlier diagnosis and differentiating benign lesions from melanoma. OBJECTIVES: We aim to investigate dermoscopic features of acral nevi, age, and localisation-related findings of these lesions. METHODS: This was an observational, descriptive study. Patients were retrospectively collected from the Department of Dermatology. The patients with acral nevi were included in the study. Inclusion criteria were Turkish nationality and the presence of at least 1 acral nevus diagnosed both clinically and dermoscopically...
May 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28564685/histopathologic-and-immunohistochemical-correlates-of-confocal-descriptors-in-pigmented-facial-macules-on-photodamaged-skin
#18
Ignacio Gómez-Martín, Sara Moreno, Evelyn Andrades-López, Inma Hernández-Muñoz, Fernando Gallardo, Carlos Barranco, Ramon M Pujol, Sonia Segura
Importance: Pigmented facial macules on photodamaged skin are a clinical, dermoscopic, and histopathologic challenge. Objectives: To clinically and dermoscopically characterize, by means of reflectance confocal microscopy (RCM), ambiguous pigmented facial macules and establish a correlation between RCM, histopathologic, and immunohistochemical findings. Design, Setting, and Participants: A prospective study of ambiguous pigmented facial macules on photodamaged skin was conducted in a tertiary referral center for dermatology between January 1, 2009, and December 31, 2015...
August 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28543606/reflectance-confocal-microscopy-analysis-of-equivocal-melanocytic-lesions-with-severe-regression
#19
M Agozzino, A Ferrari, C Cota, C Franceschini, P Buccini, L Eibenshutz, M Ardigò
BACKGROUND: The differential diagnosis between regressing nevi and melanoma might be challenging; regressing areas can represent a confounding factor for the diagnosis and the histology still remain mandatory to rule out melanoma. Reflectance confocal microscopy may add valuable information by revealing features suggestive of the nature of the melanocytic proliferation. OBJECTIVE: To assess the impact of confocal microscopy in the management of regressive melanocytic lesions...
May 21, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/28541884/an-incomplete-picture-challenges-of-partial-biopsies-in-large-diameter-atypical-melanocytic-lesions
#20
Lauren C Strazzulla, Hong Wu, Marissa Heller, Caroline C Kim
Large diameter atypical pigmented lesions (LDAPL) can be challenging to diagnose accurately using partial biopsies because of pathologic heterogeneity, while at the same time large excisions of these lesions confer significant morbidity to patients. Consequently, clinicians are often challenged by the management of these lesions. In this case, we describe an elderly patient with a history of multiple basal cell carcinomas, prior melanomas, and a family history of melanoma who presented with an irregularly pigmented brown and dark brown patch on his upper back...
April 15, 2017: Dermatology Online Journal
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