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central serous chorioretinopathy

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https://www.readbyqxmd.com/read/28426624/a-randomized-double-blind-placebo-control-pilot-study-of-eplerenone-for-the-treatment-of-central-serous-chorioretinopathy-ecselsior
#1
Ehsan Rahimy, John D Pitcher, Jason Hsu, Murtaza K Adam, Abtin Shahlaee, Wasim A Samara, James F Vander, Richard S Kaiser, Allen Chiang, Marc J Spirn, Mitchell S Fineman
PURPOSE: To evaluate the safety and effects of oral eplerenone in chronic central serous chorioretinopathy. METHODS: Prospective, randomized, double-blind, placebo-control study at a tertiary referral academic private practice. For a diagnosis of chronic central serous chorioretinopathy, patients must have had at least 3 months clinical follow-up demonstrating persistent symptoms, subfoveal fluid on spectral-domain optical coherence tomography, and <50% reduction in fluid thickness...
April 19, 2017: Retina
https://www.readbyqxmd.com/read/28424788/fully-automated-robust-system-to-detect-retinal-edema-central-serous-chorioretinopathy-and-age-related-macular-degeneration-from-optical-coherence-tomography-images
#2
Samina Khalid, M Usman Akram, Taimur Hassan, Ammara Nasim, Amina Jameel
Maculopathy is the excessive damage to macula that leads to blindness. It mostly occurs due to retinal edema (RE), central serous chorioretinopathy (CSCR), or age related macular degeneration (ARMD). Optical coherence tomography (OCT) imaging is the latest eye testing technique that can detect these syndromes in early stages. Many researchers have used OCT images to detect retinal abnormalities. However, to the best of our knowledge, no research that presents a fully automated system to detect all of these macular syndromes is reported...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28421342/selective-retina-therapy-with-automatic-real-time-feedback-controlled-dosimetry-for-chronic-central-serous-chorioretinopathy-in-korean-patients
#3
Young Gun Park, Seungbum Kang, Minhee Kim, Nari Yoo, Young Jung Roh
PURPOSE: To evaluate the safety and efficacy of selective retina therapy (SRT) with real-time feedback-controlled dosimetry (RFD) in the treatment of chronic central serous chorioretinopathy (CSC). METHODS: In this retrospective case series study, 50 eyes of 49 patients with chronic CSC demonstrating focal or diffuse foveal leakages on fundus fluorescein angiography (FFA) were included. Following evaluation of test spots at temporal arcades, SRT (wavelength 527 nm, pulse repetition rate 100 Hz, pulse energy ramp with maximal 15 pulses) with retinal spot diameter of 200 μm was applied to the areas of each leakage observed on fluorescein angiography...
April 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28419399/low-fluence-photodynamic-therapy-versus-graded-subthreshold-transpupillary-thermotherapy-for-chronic-central-serous-chorioretinopathy-results-from-a-prospective-study
#4
George J Manayath, Smita S Karandikar, Siddharth Narendran, Karan A Kumarswamy, V R Saravanan, Rodney J Morris, Narendran Venkatapathy
BACKGROUND AND OBJECTIVE: The authors compare low fluence photodynamic therapy (PDT) against graded subthreshold transpupillary thermotherapy (TTT) for chronic central serous chorioretinopathy (CSC). PATIENTS AND METHODS: Forty-two eyes of 42 patients with chronic CSC were included in this prospective, nonrandomized, interventional trial. All patients were offered PDT as an initial intervention. If they declined PDT, TTT was offered. RESULTS: Twenty patients underwent PDT and 22 underwent TTT...
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28419395/choriocapillaris-changes-imaged-by-oct-angiography-after-half-dose-photodynamic-therapy-for-chronic-central-serous-chorioretinopathy
#5
Kyoko Fujita, Akiyuki Kawamura, Mitsuko Yuzawa
BACKGROUND AND OBJECTIVE: To evaluate the choriocapillaris using optical coherence tomographic angiography (OCTA) after half-dose verteporfin photodynamic therapy (hd-PDT) for chronic central serous chorioretinopathy (CSC). PATIENTS AND METHODS: We studied six eyes (six patients) with chronic CSC treated by hd-PDT. OCTA was performed before, 1 week after, and 1 month after hd-PDT. The area of flow abnormality at the choriocapillaris level within the PDT spot after hd-PDT was compared with that before hd-PDT...
April 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28386700/clinical-efficacy-of-anti-vegf-medications-for-central-serous-chorioretinopathy-a-meta-analysis
#6
Shangli Ji, Yemei Wei, Jiansu Chen, Shibo Tang
Background Central serous chorioretinopathy (CSC) is a widespread retinal disorder, and 30-50% of patients eventually result in retinal pigment epithelium atrophy and irreversible vision loss. Aim of the review To evaluate the effectiveness of medications based on anti-vascular endothelial growth factor (anti-VEGF) on central serous chorioretinopathy (CSC). Method A systematic search on anti-VEGF medication treatments for CSC was performed in Pubmed, Embase, and the Cochrane Library prior to May 2016. The main outcome variables were best-corrected visual acuity (BCVA) and central macular thickness (CMT)...
April 6, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28384721/choroidal-vascular-flow-area-in-central-serous-chorioretinopathy-using-swept-source-optical-coherence-tomography-angiography
#7
Massimo Nicolò, Raffaella Rosa, Donatella Musetti, Maria Musolino, Michela Saccheggiani, Carlo Enrico Traverso
Purpose: To report the choroidal vascular flow area in eyes with central serous chorioretinopathy (CSC) compared with healthy subjects and unaffected fellow eyes using swept-source (SS) optical coherence tomography (OCT) angiography. Methods: Prospective case series of 19 eyes of 19 consecutive patients affected by CSC, compared with 15 unaffected fellow eyes and 20 eyes of 10 healthy subjects. Patients underwent SS-OCT angiography in order to evaluate the choroidal vascular flow area of choriocapillaris (CC) and deeper choroidal layers...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28380092/frequency-of-fibromyalgia-syndrome-in-patients-with-central-serous-chorioretinopathy
#8
Ayse Balkarli, Muhammet Kazim Erol, Ozgur Yucel, Yusuf Akar
Purpose: To ınvestigate frequency of fibromyalgia syndrome (FMS) among patients with central serous chorioretinopathy (CSCR). Methods: The study included 83 patients with CSCR and 201 age- and sex-matched healthy controls; the mean age was 47.5 ± 11.3 years in the CSCR group (18 women; 21.7%) and 47.2 ± 11.2 years in the control group (44 women; 21.9%). All participants were assessed for FMS based on 2010 American College of Rheumatology diagnostic criteria and for depression and anxiety with the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI)...
January 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28375788/real-world-experience-with-half-time-versus-half-dose-photodynamic-therapy-in-chronic-central-serous-chorioretinopathy
#9
Shu-Yen Peng, Chi-Chun Lai, Nan-Kai Wang, Wei-Chi Wu, Yih-Shiou Hwang, Kuan-Jen Chen, Lee-Jen Chen, Shawn Tsai, Wei-Chun Chan, Laura Liu, Ling Yeung
PURPOSE: To evaluate the real-world experience with half-time photodynamic therapy (PDT) versus half-dose PDT for chronic central serous chorioretinopathy (CSC). METHODS: This multicenter retrospective study enrolled patients who received half-time PDT (with irradiation time shortened to 42 s) or half-dose PDT (with the dosage of verteporfin reduced to 3 mg/m(2)) for chronic CSC and who were followed up for ≧12 months. The success rate, central subfield retinal thickness (CST), and best-corrected visual acuity (BCVA) were documented in each group of patients...
April 4, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28367162/factors-affecting-the-visual-outcome-in-acute-central-serous-chorioretinopathy
#10
Qamar Ul Islam, Muhammad Asad Farooq, Mohammad Asim Mehboob
OBJECTIVE: To determine the visual outcome in patients with acute Central serous chorioretinopathy (CSCR) and to analyze the association of clinical, angiographic and tomographic factors with final visual outcome in Pakistani population. METHODS: This study was conducted at AFIO Rawalpindi and PNS Shifa Naval hospital Karachi from November 2011 to August 2016. Fifty five eyes of 53 patients with acute CSCR were included. All patients underwent a detailed ophthalmic examination including SD OCT imaging at baseline, One month and three month and FFA was performed at baseline...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28351043/central-serous-chorioretinopathy
#11
Alejandra Daruich, Alexandre Matet, Francine Behar-Cohen
Central serous is an atypical form of macular edema with mostly accumulation of fluid under the retina. It contitutes a pure phenotype of retinal pigment epithelium barrier breakdown. Another particularity is the good visual preservation despite important fluid volume increase in the macula.
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28345567/retina-and-the-tubercle-bacillus-four-decades-of-our-journey-and-current-understanding
#12
Pradeep Venkatesh
Tuberculosis continues to be a major pandemic with enormous public health implication. Involvement of ocular tissues in the form of tubercles, tuberculomas, panophthalmitis, and iris granulomas are well recognized as definitive manifestations of tuberculosis. For these lesions, confirmatory evidence is available in the form of demonstration of acid-fast Bacillus on Ziehl-Neelsen staining. For other retinochoroidal disorders such as central serous chorioretinopathy, retinal vasculitis, and presumed ocular tuberculosis, hard evidence about the role of Mycobacterium tuberculosis is lacking...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28334414/association-of-a-haplotype-in-the-nr3c2-gene-encoding-the-mineralocorticoid-receptor-with-chronic-central-serous-chorioretinopathy
#13
Elon H C van Dijk, Rosa L Schellevis, Maaike G J M van Bergen, Myrte B Breukink, Lebriz Altay, Paula Scholz, Sascha Fauser, Onno C Meijer, Carel B Hoyng, Anneke I den Hollander, Camiel J F Boon, Eiko K de Jong
Importance: Chronic central serous chorioretinopathy (cCSC) is a chorioretinal disease with unknown disease etiology. The glucocorticoid receptor and the mineralocorticoid receptor, 2 glucocorticoid-binding receptors, might be involved in the pathogenesis of cCSC. Objective: To assess the association of functional variants and haplotypes in the glucocorticoid receptor (NR3C1) and mineralocorticoid receptor (NR3C2) genes with cCSC. Design, Setting, and Participants: In this case-control genetic association study, 336 patients with cCSC and 1314 unaffected controls, collected at 3 university medical centers from September 1, 2009, to May 1, 2016, underwent KASP genotyping for selected variants in NR3C1 (rs56149945, rs41423247, and rs6198) and NR3C2 (rs2070951 and rs5522)...
March 23, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28328626/central-serous-chorioretinopathy-in-a-patient-with-ulcerative-colitis-with-pouchitis-on-budesonide-ec
#14
Samantha Zullow, Ahad Fazelat, Francis A Farraye
No abstract text is available yet for this article.
May 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28328282/frequency-of-erectile-dysfunction-in-males-with-central-serous-chorioretinopathy
#15
Ayse Balkarli, Muhammet Kazim Erol, Soner Yalcinkaya, Rumeysa Selvinaz Erol
OBJECTIVES: To evaluate the frequency of sexual dysfunction and associated factors in patients with central serous chorioretinopathy (CSCR). MATERIAL AND METHODS: Fifty-eight CSCR patients who met the inclusion criteria and 99 age- and sex-matched healthy controls were prospectively investigated for sexual dysfunction and associated factors. All participants were investigated using the Beck Depression Inventory (BDI), Beck Anxiety Scale (BAS), and the15-question Index of Erectile Function-15 (IIEF-15) and by extensive examination of CSCR, associated factors, and confounding factors...
March 22, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28323591/treatment-and-monitoring-of-central-serous-chorioretinopathy-in-pilots
#16
Ari Shinojima, Ryusaburo Mori, Kyoko Fujita, Mitsuko Yuzawa
BACKGROUND: Central serous chorioretinopathy (CSC), which has the characteristics of a serous retinal detachment (SRD) in the macular area, affects mostly men in the 30- to 50-yr age range. Some patients have persistent SRD, which may cause retinal thinning and photoreceptor impairment. CSC symptoms are gradual vision loss and/or metamorphopsia. Some commercial airline pilots are concerned about CSC symptoms, which can disqualify them from flying for months and can also reoccur. Thus, careful monitoring and treatment of CSC are critical for pilots, especially those with chronic or recurrent CSC...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28306346/risk-factors-for-central-serous-chorioretinopathy-multivariate-approach-in-a-case-control-study
#17
Irini Chatziralli, Stamatina A Kabanarou, Efstratios Parikakis, Alexandros Chatzirallis, Tina Xirou, Panagiotis Mitropoulos
PURPOSE: The purpose of this prospective study was to investigate the potential risk factors associated independently with central serous retinopathy (CSR) in a Greek population, using multivariate approach. MATERIALS AND METHODS: Participants in the study were 183 consecutive patients diagnosed with CSR and 183 controls, matched for age. All participants underwent complete ophthalmological examination and information regarding their sociodemographic, clinical, medical and ophthalmological history were recorded, so as to assess potential risk factors for CSR...
March 17, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28283732/comparison-of-half-dose-photodynamic-therapy-and-689-nm-laser-treatment-in-eyes-with-chronic-central-serous-chorioretinopathy
#18
Andrea Russo, Raffaele Turano, Francesco Morescalchi, Elena Gambicorti, Anna Cancarini, Sarah Duse, Ciro Costagliola, Francesco Semeraro
PURPOSE: To compare visual and anatomical outcomes between half-dose photodynamic therapy (hd-PDT) and 689 nm laser therapy (689-LT) in chronic central serous chorioretinopathy (CSC). METHODS: Forty eyes of 40 patients with symptomatic chronic CSC were randomized in a 1:1 ratio to receive either hd-PDT or 689-LT delivering 95 J/cm(2) via an intensity application of 805 mW/cm(2) over 118 s. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography findings were compared between the two treatment groups...
March 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28277988/therapy-rationale-for-mineralocorticoid-receptor-antagonists-acetazolamide-and-a-switch-of-therapy-in-nonresponders-in-central-serous-chorioretinopathy
#19
Anne Rübsam, Claudia E Thieme, Juliane Schlomberg, Sibylle Winterhalter, Bert Müller, Antonia M Joussen, Nicole Stübiger
PURPOSE: To evaluate the efficacy of mineralocorticoid-receptor antagonists in comparison to acetazolamide and observation in the treatment of central serous chorioretinopathy. METHODS: Retrospective, interventional cohort study on 93 patients with acute or chronic central serous chorioretinopathy (37 patients: acetazolamide group, 20 patients: mineralocorticoid-receptor antagonist group, 8 patients: observation group, and 27 patients with a therapy switch between both medications)...
April 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28267114/optical-coherence-tomography-angiography-of-flat-irregular-pigment-epithelium-detachment-in-chronic-central-serous-chorioretinopathy
#20
Elodie Bousquet, Sophie Bonnin, Sarah Mrejen, Valérie Krivosic, Ramin Tadayoni, Alain Gaudric
PURPOSE: To assess the rate of choroidal neovascularization (CNV) detected by optical coherence tomography angiography (OCTA) in flat irregular pigment epithelium detachment (PED) in chronic central serous chorioretinopathy. METHODS: Data on all consecutive patients with chronic central serous chorioretinopathy who underwent OCTA over a 1-year period were reviewed. The presence of flat irregular PED, which was defined as an irregular elevation of the retinal pigment epithelium allowing the visualization of a distinct Bruch's membrane was assessed on high-resolution OCT B-scan...
March 3, 2017: Retina
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