keyword
https://read.qxmd.com/read/38536434/the-analysis-of-boric-acid-effect-on-epithelial-mesenchymal-transition-of-cd133%C3%A2-%C3%A2-cd117%C3%A2-%C3%A2-lung-cancer-stem-cells
#1
JOURNAL ARTICLE
Tuğba Semerci Sevimli, Murat Sevimli, Aynaz Ghorbani, Varol Şahintürk, Emilia Qomi Ekenel, Tuğba Ertem, Bahar Demir Cevizlidere, Burcugül Altuğ, Özlem Tomsuk, Onur Uysal, Sibel Güneş Bağış, Hüseyin Avci, Fatih Çemrek, Zarifa Ahmadova
Targeting lung cancer stem cells (LC-SCs) for metastasis may be an effective strategy against lung cancer. This study is the first on epithelial-mesenchymal transition (EMT) properties of boric acid (BA) in LC-SCs. LC-SCs were isolated using the magnetic cell sorting (MACS) method. Tumor-sphere formation and flow cytometry confirmed CSC phenotype. The cytotoxic effect of BA was measured by MTT analysis, and the effect of BA on EMT was examined by migration analysis. The expression levels of ZEB1, SNAIL1, ITGA5, CDH1, ITGB1, VIM, COL1A1, and LAMA5 genes were analyzed by RT-qPCR...
March 27, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38534924/modeling-5-fu-induced-chemotherapy-selection-of-a-drug-resistant-cancer-stem-cell-subpopulation
#2
JOURNAL ARTICLE
Amra Ramović Hamzagić, Danijela Cvetković, Marina Gazdić Janković, Nevena Milivojević Dimitrijević, Dalibor Nikolić, Marko Živanović, Nikolina Kastratović, Ivica Petrović, Sandra Nikolić, Milena Jovanović, Dragana Šeklić, Nenad Filipović, Biljana Ljujić
(1) Background: Cancer stem cells (CSCs) are a subpopulation of cells in a tumor that can self-regenerate and produce different types of cells with the ability to initiate tumor growth and dissemination. Chemotherapy resistance, caused by numerous mechanisms by which tumor tissue manages to overcome the effects of drugs, remains the main problem in cancer treatment. The identification of markers on the cell surface specific to CSCs is important for understanding this phenomenon. (2) Methods: The expression of markers CD24, CD44, ALDH1, and ABCG2 was analyzed on the surface of CSCs in two cancer cell lines, MDA-MB-231 and HCT-116, after treatment with 5-fluorouracil (5-FU) using flow cytometry analysis...
February 25, 2024: Current Oncology
https://read.qxmd.com/read/38534757/to-repair-a-broken-heart-stem-cells-in-ischemic-heart-disease
#3
REVIEW
Theodora M Stougiannou, Konstantinos C Christodoulou, Ioannis Dimarakis, Dimitrios Mikroulis, Dimos Karangelis
Despite improvements in contemporary medical and surgical therapies, cardiovascular disease (CVD) remains a significant cause of worldwide morbidity and mortality; more specifically, ischemic heart disease (IHD) may affect individuals as young as 20 years old. Typically managed with guideline-directed medical therapy, interventional or surgical methods, the incurred cardiomyocyte loss is not always completely reversible; however, recent research into various stem cell (SC) populations has highlighted their potential for the treatment and perhaps regeneration of injured cardiac tissue, either directly through cellular replacement or indirectly through local paracrine effects...
March 8, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533413/mnemonic-utilization-in-stroke-education-fast-and-befast-adoption-by-certified-comprehensive-stroke-centers
#4
JOURNAL ARTICLE
Christopher Hogge, Larry B Goldstein, Sushanth R Aroor
INTRODUCTION: Symptom recognition and timely access to treatment are critical components of acute stroke care systems. Two mnemonics widely used in public educational campaigns for recognizing stroke symptoms include FAST (Face-Arm-Speech-Time) and BEFAST (Balance-Eyes-Face-Arm Speech-Time). The FAST mnemonic can miss up to 14% of strokes. BEFAST includes common posterior circulation stroke symptoms and has been implemented by several Comprehensive Stroke Centers (CSCs). METHODS: We sought to analyze the pattern of public educational materials available on the websites of US CSCs...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38532691/reimbursement-for-a-broader-array-of-services-in-coordinated-specialty-care-for-early-psychosis
#5
JOURNAL ARTICLE
Matthew E Hirschtritt, Brandon Staglin, Stuart Buttlaire, Kerry Ahearn, Sarada Oglesby, Lisa B Dixon, David Shern, Toby Ewing, Tara A Niendam
Despite the growing evidence supporting the benefits of coordinated specialty care (CSC) for early psychosis, access to this multimodal, evidence-based program in the United States has been hindered by a lack of funding for core CSC services and activities. The recent approval of team-based reimbursement codes by the Centers for Medicare and Medicaid Services has the potential to fund substantially more CSC services for clients with insurance coverage that accepts the new team-based billing codes. This streamlined and more inclusive billing strategy may reduce administrative burden and support the financial viability of CSC programs...
March 27, 2024: Psychiatric Services: a Journal of the American Psychiatric Association
https://read.qxmd.com/read/38531681/central-serous-chorioretinopathy-a-review
#6
REVIEW
Manethová Myslík, Kateřina
Central serous chorioretinopathy (CSC) is a disease characterized by serous detachment of the neuroretina, especially in the posterior pole of the eye. It is often accompanied by serous detachment of the retinal pigment epithelium (RPE) and associated with the leakage of fluid into the subretinal space through the defective RPE. CSC most often affects men of working age. The exact pathophysiology of the disease is not completely known. Based on indocyanine green angiography (ICG), which revealed increased permeability of choroidal vessels, and optical coherence tomography (OCT) showing increased choroidal thickness, choroidal vasculopathy is assumed to be the primary cause of CSC...
2024: Ceská a Slovenská Oftalmologie
https://read.qxmd.com/read/38530784/retraction-long-non-coding-rna-hotair-regulates-the-proliferation-self-renewal-capacity-tumor-formation-and-migration-of-the-cancer-stem-like-cell-csc-subpopulation-enriched-from-breast-cancer-cells
#7
https://read.qxmd.com/read/38529362/efficacy-and-predictive-factors-of-oral-spironolactone-treatment-in-chronic-central-serous-chorioretinopathy
#8
JOURNAL ARTICLE
Sheng Gao, Yun Zhang, Meixia Zhang
PURPOSE: To evaluate the efficacy of spironolactone in the treatment of chronic central serous chorioretinopathy (CSC) and identify imaging characteristics that can predict the benefit of spironolactone treatment. METHODS: Patients with chronic CSC were treated with spironolactone (20 mg/tid) and followed for 6 months. The primary outcome measure was complete resolution of the subretinal fluid (SRF), and the best-corrected visual acuity (BCVA), the SRF area, the central macular thickness (CMT), the subfoveal choroidal thickness (SFCT), and the density of the choriocapillaris vessel and adverse events were secondary outcome measures...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38528654/cd44-and-cd133-protein-expression-might-serve-as-a-prognostic-factor-for-early-occurrence-castration-resistant-prostate-cancer
#9
JOURNAL ARTICLE
Yayi Dwina, Litta Septina Mahmelia Zaid, Meilania Saraswati, Lisnawati Rachmadi, Aria Kekalih, Nur Rahadiani, Melva Louisa, Hasrayati Agustina, Chaidir Arif Mochtar, Agus Rizal Ardy Hariandy Hamid
BACKGROUND: The occurrence of castration-resistant prostate cancer (CRPC) varies in patients with advanced prostate cancer (PCa) undergoing androgen deprivation therapy (ADT). The rate of occurrence of CRPC may be related to the presence of prostate cancer stem cells (CSC). Thus, this study aims to evaluate the presence of CSC markers (CD44 and CD133) in histopathology tissue at the time of diagnosis and their correlation with the occurrence of CRPC in patients with advanced PCa within 2 years of ADT...
March 25, 2024: Prostate
https://read.qxmd.com/read/38522013/epidermal-growth-factor-receptor-inhibition-potentiates-chemotherapeutics-mediated-sensitization-of-metastatic-breast-cancer-stem-cells
#10
JOURNAL ARTICLE
Trisha Kar, Prachi Dugam, Surbhi Shivhare, Swathi R Shetty, Subholakshmi Choudhury, Debanjan Sen, Barnali Deb, Swapan Majumdar, Sudhan Debnath, Amitava Das
BACKGROUND: Metastasis has been a cause of the poor prognosis and cancer relapse of triple-negative breast cancer (TNBC) patients. The metastatic nature of TNBC is contributed by the breast cancer stem cells (CSCs) which have been implicated in tumorigenesis. Higher expression of epidermal growth factor receptor (EGFR) in breast CSCs has been used as a molecular target for breast cancer therapeutics. Thus, it necessitates the design and generation of efficacious EGFR inhibitors to target the downstream signaling associated with the cellular proliferation and tumorigenesis of breast cancer...
March 2024: Cancer reports
https://read.qxmd.com/read/38521868/single-cell-and-spatial-analyses-revealed-the-co-location-of-cancer-stem-cells-and-spp1-macrophage-in-hypoxic-region-that-determines-the-poor-prognosis-in-hepatocellular-carcinoma
#11
JOURNAL ARTICLE
Guangyu Fan, Tongji Xie, Lin Li, Le Tang, Xiaohong Han, Yuankai Shi
In hepatocellular carcinoma (HCC), classical cancer stem cells (CSC) markers were shared by normal stem cells, targeting which may hinder hepatic regeneration and cause liver failure. Additionally, the spatial structure of CSC still remained elusive. To address these limitations, we undertook a comprehensive study combining single-cell data (56,022 cells from 20 samples) and spatial data (38,191 spots from eight samples) to obtain CSC signature and uncover its spatial structure. Utilizing the CytoTRACE algorithm, we discretely identified CSC, which displayed upregulated proliferation pathways regulated by HIF1A...
March 23, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38521148/edi-oct-as-an-auxiliary-examination-for-the-differential-diagnosis-of-bullous-csc-and-vogt-koyanagi-harada-a-case-report
#12
Yuanyuan Zhang, Chenwei Gui, Tianyu Wang, Jianhao Bai, Zhongqi Wan, Lei Gao, Qing Peng
A 46-year-old male patient visited our clinic with a complaint of blurred vision in the right eye accompanied by headache and insomnia. The fundus examination showed three bullous retinal detachments in the right eye. Considering the prodromal symptoms and other fundus characteristics such as vitreous cells in the posterior pole and multifocal fluorescence leakages on fundus fluorescein angiography (FFA), initial diagnosis was considered as Vogt-Koyanagi-Harada (VKH). However, oral glucocorticoids didn't improve patient's vision...
March 21, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38517618/dynamic-interplay-of-nuclear-receptors-in-tumor-cell-plasticity-and-drug-resistance-shifting-gears-in-malignant-transformations-and-applications-in-cancer-therapeutics
#13
REVIEW
Bandari BharathwajChetty, Anjana Sajeev, Ravichandran Vishwa, Babu Santha Aswani, Mohammed S Alqahtani, Mohamed Abbas, Ajaikumar B Kunnumakkara
Recent advances have brought forth the complex interplay between tumor cell plasticity and its consequential impact on drug resistance and tumor recurrence, both of which are critical determinants of neoplastic progression and therapeutic efficacy. Various forms of tumor cell plasticity, instrumental in facilitating neoplastic cells to develop drug resistance, include epithelial-mesenchymal transition (EMT) alternatively termed epithelial-mesenchymal plasticity, the acquisition of cancer stem cell (CSC) attributes, and transdifferentiation into diverse cell lineages...
March 22, 2024: Cancer Metastasis Reviews
https://read.qxmd.com/read/38514830/involvement-of-tgfbi-tagln-axis-in-cancer-stem-cell-property-of-head-and-neck-squamous-cell-carcinoma
#14
JOURNAL ARTICLE
Motoharu Sarubo, Yasuhiro Mouri, Akira Moromizato, Azusa Yamada, Shengjan Jin, Wenhua Shao, Hiroko Hagita, Keiko Miyoshi, Yasusei Kudo
Head and neck squamous cell carcinoma (HNSCC) is a significant healthcare burden globally. Previous research using single-cell transcriptome analysis identified TGFBI as a crucial marker for the partial-epithelial-mesenchymal transition (partial-EMT) program. However, the precise role of TGFBI in HNSCC progression remains unclear. Therefore, our study aimed to clarify the impact of TGFBI on the malignant behavior of HNSCC cells. Through RNA-sequencing data from the TCGA database, we validated that increased TGFBI expression correlates with a higher occurrence of lymph node metastasis and unfavorable prognosis in HNSCC cases...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38509504/transgelin-2-a-novel-cancer-stem-cell-related-biomarker-is-a-diagnostic-and-therapeutic-target-for-biliary-tract-cancer
#15
JOURNAL ARTICLE
Jung Hyun Jo, Soo Been Park, Joowon Chung, Taeyun Oh, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Dawoon E Jung, Si Young Song
BACKGROUND: Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for the low response to anti-cancer treatment and the high recurrence rate. This study investigated the role of Transgelin-2 (TAGLN2), overexpressed in CSC in BTC cells, and analyzed its expression in patient tissues and serum to identify potential new targets for BTC. METHODS: TAGLN2 expression was suppressed by small-interfering or short hairpin RNAs, and its effects on tumor biology were assessed in several BTC cell lines...
March 20, 2024: BMC Cancer
https://read.qxmd.com/read/38505168/anti-tumor-efficacy-of-oleuropein-loaded-zno-au-mesoporous-silica-nanoparticle-in-5-fu-resistant-colorectal-cancer-cells
#16
JOURNAL ARTICLE
Sang Mi Park, Da Yeon Kim, Kyeong Hyeon Lee, Yong-Il Shin, Sang-Cheol Han, Sang-Mo Kwon
PURPOSE: 5-fluorouracil (5-FU) is a first-line chemotherapeutic agent used to treat colorectal cancer (CRC). However, 5-FU induces drug resistance and activation of cancer stem cells (CSCs). In the present study, we designed a novel biocompatible nanomedicine system with high efficacy and biocompatibility by synthesizing mesoporous silica nanoparticle (MSN)-structured ZnO and gold ions. Oleuropein (OLP) is a phenolic compound derived from olive leaves that exerts anti-cancer effects. Therefore, we synthesized OLP-loaded ZnO/Au MSNs (ZnO/Au/OLP MSNs) and examined their anti-cancer effects on 5-FU-resistant CRC cells...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38504385/linc00909-up-regulates-pluripotency-factors-and-promotes-cancer-stemness-and-metastasis-in-pancreatic-ductal-adenocarcinoma-by-targeting-smad4
#17
JOURNAL ARTICLE
Zhenchong Li, Zuyi Ma, Shujie Wang, Qian Yan, Hongkai Zhuang, Zixuan Zhou, Chunsheng Liu, Yubin Chen, Mingqian Han, Zelong Wu, Shanzhou Huang, Qi Zhou, Baohua Hou, Chuanzhao Zhang
BACKGROUND: Pancreatic cancer stem cells are crucial for tumorigenesis and cancer metastasis. Presently, long non-coding RNAs were found to be associated with Pancreatic Ductal Adenocarcinoma stemness characteristics but the underlying mechanism is largely known. Here, we aim to explore the function of LINC00909 in regulating pancreatic cancer stemness and cancer metastasis. METHODS: The expression level and clinical characteristics of LINC00909 were verified in 80-paired normal pancreas and Pancreatic Ductal Adenocarcinoma tissues from Guangdong Provincial People's Hospital cohort by in situ hybridization...
March 19, 2024: Biology Direct
https://read.qxmd.com/read/38504374/tmem120b-strengthens-breast-cancer-cell-stemness-and-accelerates-chemotherapy-resistance-via-%C3%AE-1-integrin-fak-taz-mtor-signaling-axis-by-binding-to-myh9
#18
JOURNAL ARTICLE
Ran Hu, Yu Cao, Yuanyuan Wang, Tingting Zhao, Kaibo Yang, Mingwei Fan, Mengyao Guan, Yuekang Hou, Jiao Ying, Xiaowen Ma, Ning Deng, Xun Sun, Yong Zhang, Xiupeng Zhang
BACKGROUND: Breast cancer stem cell (CSC) expansion results in tumor progression and chemoresistance; however, the modulation of CSC pluripotency remains unexplored. Transmembrane protein 120B (TMEM120B) is a newly discovered protein expressed in human tissues, especially in malignant tissues; however, its role in CSC expansion has not been studied. This study aimed to determine the role of TMEM120B in transcriptional coactivator with PDZ-binding motif (TAZ)-mediated CSC expansion and chemotherapy resistance...
March 19, 2024: Breast Cancer Research: BCR
https://read.qxmd.com/read/38503478/evaluation-and-model-to-achieve-sex-parity-in-cataract-surgical-coverage-in-theni-district-india
#19
JOURNAL ARTICLE
Sachin Gupta, Ravilla D Ravindran, Ashok Vardhan, Thulasiraj D Ravilla
BACKGROUND/AIMS: To propose an approach to determine the target ratio of cataract surgical rates (CSRs) of female to male subpopulations to increase sex parity in cataract surgical coverage (CSC), based on the sex gap in cataract burden and incidence, and demonstrate its application to Theni district, India. METHODS: A population-based longitudinal study between January 2016 and April 2018. We recruited 24 327 participants using random cluster sampling. We conducted detailed eye examinations of 7087 participants aged ≥40 years (4098 females, 2989 males)...
March 19, 2024: British Journal of Ophthalmology
https://read.qxmd.com/read/38503384/exploiting-transcription-factors-to-target-emt-and-cancer-stem-cells-for-tumor-modulation-and-therapy
#20
REVIEW
Abdul Q Khan, Adria Hasan, Snober S Mir, Khalid Rashid, Shahab Uddin, Martin Stienhoff
Transcription factors (TFs) are essential in controlling gene regulatory networks that determine cellular fate during embryogenesis and tumor development. TFs are the major players in promoting cancer stemness by regulating the function of cancer stem cells (CSCs). Understanding how TFs interact with their downstream targets for determining cell fate during embryogenesis and tumor development is a critical area of research. CSCs are increasingly recognized for their significance in tumorigenesis and patient prognosis, as they play a significant role in cancer initiation, progression, metastasis, and treatment resistance...
March 17, 2024: Seminars in Cancer Biology
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