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G Mazziotti, F Maffezzoni, S Frara, A Giustina
Acromegalic osteopathy is an emerging complication of acromegaly characterized by increase in bone turnover, deterioration in bone microarchitecture and high risk of vertebral fractures. Vertebral fractures, as diagnosed by a radiological and morphometric approach, occur in about one-third of acromegaly patients in close relationship with duration of active disease. However, the prediction of vertebral fractures in this clinical setting is still a matter of uncertainty, since the pathogenesis of acromegalic osteopathy is multifactorial and fractures may occur even in presence of normal bone mineral density...
October 5, 2016: Pituitary
M Sillem, I Juhasz-Böss, I Klausmeier, S Mechsner, F Siedentopf, E Solomayer
Introduction: Pelvic pain is a common problem in gynaecological practice. It is often unclear whether definite causality exists between reported symptoms and objective clinical findings of the female genital tract, and medical or operative treatments do not always achieve long-term resolution of symptoms. Methods: This pilot study investigated 28 patients (age 20-65, median 36.5 years) from a gynaecology practice whose only clinical finding was painful pelvic floor muscle tightness. Following standardised gynaecological and physiotherapist examination, all patients received osteopathic treatment...
September 2016: Geburtshilfe und Frauenheilkunde
Kannikar Wongdee, Nateetip Krishnamra, Narattaphol Charoenphandhu
Both types 1 and 2 diabetes mellitus (T1DM and T2DM) are associated with profound deterioration of calcium and bone metabolism, partly from impaired intestinal calcium absorption, leading to a reduction in calcium uptake into the body. T1DM is associated with low bone mineral density (BMD) and osteoporosis, whereas the skeletal changes in T2DM are variable, ranging from normal to increased and to decreased BMD. However, both types of DM eventually compromise bone quality through production of advanced glycation end products and misalignment of collagen fibrils (so-called matrix failure), thereby culminating in a reduction of bone strength...
September 26, 2016: Journal of Physiological Sciences: JPS
Helen Hall, Holger Cramer, Tobias Sundberg, Lesley Ward, Jon Adams, Craig Moore, David Sibbritt, Romy Lauche
BACKGROUND: Low back pain and pelvic girth pain are common in pregnancy and women commonly utilize complementary manual therapies such as massage, spinal manipulation, chiropractic, and osteopathy to manage their symptoms. OBJECTIVE: The aim of this systematically review was to critically appraise and synthesize the best available evidence regarding the effectiveness of manual therapies for managing pregnancy-related low back and pelvic pain. METHODS: Seven databases were searched from their inception until April 2015 for randomized controlled trials...
September 2016: Medicine (Baltimore)
Gail C Hanson, Bruce Jones, Catherine J Bacon, Robert W Moran
To explore clinical changes following a novel manual mobilisation technique, 24 participants who experienced 'moderate' to 'severe' chronic low back pain were recruited from new patients attending a suburban osteopathy clinic. The intervention was a previously undescribed side-lying mobilisation technique targeting the lumbosacral spine (median of 6 treatment sessions). After 8 weeks reductions were shown in Oswestry Disability Index of 15 points (95% CI: 9.3, 22.7; p < 0.0001 for overall ANOVA); Quadruple Visual Analogue Scale of 2...
July 2016: Journal of Bodywork and Movement Therapies
Yue Guo, Chen-Yi Tang, Xiao-Fei Man, Hao-Neng Tang, Jun Tang, Fang Wang, Ci-La Zhou, Shu-Wen Tan, Yun-Zhi Feng, Hou-De Zhou
Insulin promotes bone formation via a well-studied canonical signaling pathway. An adapter in this pathway, insulin-receptor substrate (IRS)-1, has been implicated in the diabetic osteopathy provoked by impaired insulin signaling. To further investigate IRS-1's role in the bone metabolism, we generated Irs-1-deficient mice (Irs-1(smla/smla)). These null mice developed a spontaneous mutation that led to an increase in trabecular thickness (Tb.Th) in 12-mo-old, but not in 2-mo-old mice. Analyses of the bone marrow stromal cells (BMSCs) from these mice revealed their differential expression of osteogenesis-related genes and miRNAs...
September 13, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Noa Safra, Peta L Hitchens, Emanual Maverakis, Anupam Mitra, Courtney Korff, Eric Johnson, Amir Kol, Michael J Bannasch, Niels C Pedersen, Danika L Bannasch
Metaphyseal osteopathy (MO) (hypertrophic osteodystrophy) is a developmental disorder of unexplained etiology affecting dogs during rapid growth. Affected dogs experience relapsing episodes of lytic/sclerotic metaphyseal lesions and systemic inflammation. MO is rare in the general dog population; however, some breeds (Weimaraner, Great Dane and Irish Setter) have a much higher incidence, supporting a hereditary etiology. Autoinflammatory childhood disorders of parallel presentation such as chronic recurrent multifocal osteomyelitis (CRMO), and deficiency of interleukin-1 receptor antagonist (DIRA), involve impaired innate immunity pathways and aberrant cytokine production...
October 15, 2016: Veterinary Immunology and Immunopathology
Francesco Cerritelli, Marco Verzella, Luca Cicchitti, Giandomenico D'Alessandro, Nicola Vanacore
BACKGROUND: Placebo, defined as "false treatment," is a common gold-standard method to assess the validity of a therapy both in pharmacological trials and manual medicine research where placebo is also referred to as "sham therapy." In the medical literature, guidelines have been proposed on how to conduct robust placebo-controlled trials, but mainly in a drug-based scenario. In contrast, there are not precise guidelines on how to conduct a placebo-controlled in manual medicine trials (particularly osteopathy)...
August 2016: Medicine (Baltimore)
Katharina Blatt, Harald Herrmann, Gabriele Stefanzl, Wolfgang R Sperr, Peter Valent
Multiple myeloma (MM) is a malignancy characterized by monoclonal paraproteinemia and tissue plasmocytosis. In advanced MM cytopenia and osteopathy may occur. Although several effective treatment strategies have been developed in recent years, there is still a need to identify new drug targets and to develop more effective therapies for patients with advanced MM. We examined the effects of 15 targeted drugs on growth and survival of primary MM cells and 5 MM cell lines (MM.1S, NCI-H929, OPM-2, RPMI-8226, U-266)...
August 25, 2016: Oncotarget
Brett Vaughan, Jane Mulcahy, Kylie Fitzgerald
Adequate levels of health literacy (HL) are required for patients to access appropriate health services and develop an understanding of the options for managing their healthcare needs. There is limited literature on HL of patients seeking care for a musculoskeletal complaint. The present study sought to screen the HL of patients presenting to an Australian osteopathy student-led clinic using a single screening question 'Are you confident completing medical forms?'. Less than 10% of patients attending the clinic were considered to have below adequate levels of HL using this question, consistent with other work in Australian populations...
August 2016: Complementary Therapies in Clinical Practice
Eléonore Aveni, Brent Bauer, Anne-Sylvie Ramelet, Yolande Kottelat, Isabelle Decosterd, Guillaume Finti, Pierluigi Ballabeni, Eric Bonvin, Pierre-Yves Rodondi
OBJECTIVE: To assess the attitudes of physicians, nurses, physical therapists, and midwives toward complementary medicine (CM) at a Swiss academic hospital and toward its use for treating chronic pain. DESIGN: The cross-sectional survey took place from October to December 2013. SETTING: An e-mail sent to 4925 healthcare professionals (1969 physicians, 2372 nurses, 145 physical therapists, and 111 midwives) working at Lausanne University Hospital, Switzerland, invited them to answer a web-based questionnaire...
September 2016: Explore: the Journal of Science and Healing
Samuel Morris, James Booth, James Hegarty
PURPOSE: The study reports the feasibility of implementing routine registry data collection and sustaining a high rate of data capture within a secondary care spinal osteopathy service, using the Spine Tango Conservative registry data collection tool (STC) with multiple patient-reported outcome measures (PROMs): Oswestry Disability Index (ODI), Neck Disability Index (NDI), COMI Low Back Conservative, COMI Neck Conservative and EQ-5D-3L. METHODS: Data collection rates were studied during the implementation of a registry data collection project from October 2011 to June 2015...
September 2016: European Spine Journal
Gilad Segev, Hagar Meltzer, Anna Shipov
Secondary renal hyperparathyroidism is an inevitable consequence of chronic kidney disease. In human patients, the disease is associated with decreased bone quality and increased fracture risk. Recent evidence suggests that bone quality is also decreased in companion animals, more pronouncedly in cats compared with dogs, likely because of a longer disease course. The clinical significance of these findings is yet to be determined. However, clinicians should keep in mind that animals with chronic kidney disease have decreased bone quality and increased fracture risk...
November 2016: Veterinary Clinics of North America. Small Animal Practice
Brett Vaughan, Sandra Grace
BACKGROUND: Peer physical examination (PPE) is an efficient and practical educational approach whereby students can practise their examination skills on each other before commencing clinical practice with actual patients. Little is known about the use of PPE in osteopathy education. METHODS: Students in Year 1 of the osteopathy programs at Victoria University (Melbourne, Australia) and Southern Cross University (Lismore, Australia) completed the Examining Fellow Students and the Peer Physical Examination questionnaires prior to, and at the completion of, their first 12-week teaching session...
2016: Chiropractic & Manual Therapies
Patrick McLaughlin, Brett Vaughan, James Shanahan, Jake Martin, Gabriel Linger
The Foot Posture Index (FPI-6) is a reliable (experienced examiners) assessment tool used in clinical practice to classify foot posture. No work has been completed to determine the reliability of the FPI-6 between novice examiners. Therefore, the aim was to determine the inter-examiner reliability of the FPI-6 using two novice examiners (graduate level osteopathy students). The FPI-6 was used to classify the feet of 83 students recruited as part of a larger study. Data were collected simultaneously by both examiners, but there was no communication between them...
June 21, 2016: Manual Therapy
Diana Crego-Vita, Daniel Aedo-Martín, Coral Sánchez-Pérez
Paget's disease of bone is a localised chronic osteopathy which produces bone deformities, bone hypervascularity, structural weakness and altered joint biomechanics. Although radiological diagnosis of Paget's disease of bone is usually straightforward, monostotic cases may potentially raise specific problems which require invasive and expensive procedures such as bone biopsies. The pelvis and upper femur are frequently affected, resulting in disabling hip disease that may require total hip arthroplasty. We report a case of Paget disease of bone in an 84-year-old woman, which was initially identified as avascular necrosis of the hip, reason for which she underwent total hip arthroplasty...
2016: International Journal of Surgery Case Reports
Stefano Piaserico, Paolo Gisondi, Paolo Amerio, Giuseppe Amoruso, Anna Campanati, Andrea Conti, Clara De Simone, Giulio Gualdi, Claudio Guarneri, Anna Mazzotta, Maria L Musumeci, Damiano Abeni
Psoriatic arthritis (PsA) is a potentially severe inflammatory condition (entheso-arthro-osteopathy), and early diagnosis is important to guide treatment choices in patients with psoriasis. The objective of this study is to further validate the PsA Screening and Evaluation (PASE) questionnaire, and to assess its field performance. Data were collected in 10 Italian centres, and the PASE was administered at baseline, after 3 days and after 3 months. The Skindex-29 was also administered. To determine the best cut-off value to identify patients with PsA we produced receiver operating characteristic (ROC) curves using the rheumatologist's diagnosis as outcome...
August 23, 2016: Acta Dermato-venereologica
Katherine Bradbury, Miznah Al-Abbadey, Dawn Carnes, Borislav D Dimitrov, Susan Eardley, Carol Fawkes, Jo Foster, Maddy Greville-Harris, J Matthew Harvey, Janine Leach, George Lewith, Hugh MacPherson, Lisa Roberts, Laura Parry, Lucy Yardley, Felicity L Bishop
INTRODUCTION: Components other than the active ingredients of treatment can have substantial effects on pain and disability. Such 'non-specific' components include: the therapeutic relationship, the healthcare environment, incidental treatment characteristics, patients' beliefs and practitioners' beliefs. This study aims to: identify the most powerful non-specific treatment components for low back pain (LBP), compare their effects on patient outcomes across orthodox (physiotherapy) and complementary (osteopathy, acupuncture) therapies, test which theoretically derived mechanistic pathways explain the effects of non-specific components and identify similarities and differences between the therapies on patient-practitioner interactions...
2016: BMJ Open
Ahmed Rashid
No abstract text is available yet for this article.
June 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Kwang Sik Suh, Suk Chon, Eun Mi Choi
Methylglyoxal (MG), a reactive sugar-derived metabolite, exerts harmful effects by inducing oxidative stress, which aggravates a series of diabetic complications, including osteoporosis. The present study was performed to examine the effects of luteolin, a dietary polyphenolic flavonoid, on MG-induced cytotoxicity in MC3T3-E1 osteoblastic cells. Pretreatment of MC3T3-E1 osteoblastic cells with luteolin prevented MG-induced cell death and production of tumor necrosis factor-alpha, intracellular reactive oxygen species, mitochondrial superoxide, and cardiolipin peroxidation...
May 24, 2016: Cytotechnology
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