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Tao Zhang, Yue-Qiao Hu, Tian Han, Yuan-Qi Zhai, Yan-Zhen Zheng
We report herein a new cobalt(II/III) mixed-valence metal-organic framework formulated as [CoII Co2 III (μ3 -O)(bdc)3 (tpt)]·guest 1, where bdc = benzene-1,4-dicarboxylate and tpt = 2,4,6-tri(4-pyridinyl)-1,3,5-triazine, which can be used as a redox-active heterogeneous catalyst for selective oxidation of cyclohexene on the allylic position without destroying the adjacent double bond. Two oxidants were chosen to demonstrate this result. For using tert-butyl hydroperoxide, the conversion rate is 63% and only allylic oxidation products ( tert-butyl-2-cyclohexenyl-1-peroxide, 86%; 2-cyclohexen-1-one, 14%) are found, whereas if using O2 as oxidant, a total conversion of 38% is achieved and also only the allylic oxidation products (cyclohexenyl hydroperoxide, 72%; 2-cyclohexen-1-one, 20%; and cyclohex-2-en-1-ol, 8%) are found...
May 9, 2018: ACS Applied Materials & Interfaces
Takehisa Hanawa, Yayoi Kawano, Mitsutoshi Satoh
 Anticancer drug-induced stomatitis develops in 30% to 40% of cancer patients undergoing chemotherapy. However, medications for this condition are not commercially available in Japan. The "hospital formulation" is a customized medicine which hospital pharmacists prepare when doctors cannot carry out the medical therapy most suitable for a patient using commercial medicines. However, as the duties of pharmacists increase, use of the "hospital fomulation" decreases. Therefore, development of "hospital fomulations" based on individual evidence has a limit...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Saeed Ghanbarzadeh, Hadi Valizadeh, Shadi Yaqoubi, Arash Asdagh, Hamed Hamishehkar
BACKGROUND: Tablets and capsules are the most accepted and widely used solid dosage forms in the medical therapy. Flow property of the powders is playing a key role in the various pharmaceutical fields especially in the fomulation of tablets and capsules. The high hygroscopic crystalline structure of anhydrous Divalproex sodium (DVX) makes it to be appear as waxy white flakes with almost no powder flowability which cause serious problems during the tabletting and capsule filling procedures...
March 2018: Drug Research
Francesco Marras, Paolo Tranquilli Leali
Painful symptomatology in the skeletal system can be found in various pathological conditions and can be either localised or diffused. Bone tenderness is common in those who are of an elderly age. TREATMENT STRATEGY: Patients should be informed of the possible causes of their pain and the different therapies that could alleviate it; furthermore they should be encouraged to have an active role in their therapy. It is necessary to prevent the onset of the pain (by the clock) by considering the biological half-life, the bioavailability and the duration of action of the therapy...
May 2016: Clinical Cases in Mineral and Bone Metabolism
Xiaofeng Xu, Yan Shen, Wei Wang, Chunmeng Sun, Chang Li, Yerong Xiong, Jiasheng Tu
The aim of the present work was to develop a nasal delivery system of phenylephrine hydrochloride (PE) in spray form to make prolonged remedy of nasal congestion. The formulations contain the thermosensitive hydrogel, i.e., Poloxamer 407 (P407) and Poloxamer 188 (P188) mixtures, and mucoadhesives, i.e., ε-polylysine (ε-PL) and low molecular weight sodium hyaluronate (MW 11,000Da). The in vitro characterizations of formulations including rheology studies, texture profiles and in vitro mucoadhesion potential were investigated after gelation temperatures measurements...
November 2014: European Journal of Pharmaceutics and Biopharmaceutics
Lihua Tan, Shuanglin Zeng, Cong Ma, Shunke Zhou, Fan Kuang
OBJECTIVE: To diagnoze active ankylosing spondylitis (AAS) by magnetic resonance imaging (MRI). METHODS: MRI of the sacroiliac joint (SIJ) was performed on 48 patients who were clinically diagnosed as probable AS without radiologic evidence of sacroiliitis. Among them 21 were diagnozed as active sacroiliitis with MRI, whose examination was terminated; 27 whose MRI of SIJ did not diagnoze as active sacroiliitis were performed MRI in the thoracic spine. The diagnostic criteria of MRI for AAS of SIJ and/or the thoracic spine were fomulated by consulting documents...
March 2013: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
S Li, Y Q Qiu, S H Zhang, Y H Gao
The aim of this study was to develop a novel topical liposomal system entrapping 18β-glycyrrhetic acid (GA) for the treatment of chronic allergic dermatitis. A novel liposomal system with molar ratios of GA to lysine from 1:1 to 1:3 was prepared by high-pressure homogenization. The liposomes at the optimized molar ratio of GA to lysine of 1:2 significantly improved GA loading (1.2%) and penetration in vitro. Liposomal gels containing GA 0.3, 0.6 and 0.9% were prepared to investigate the dosage effect on transdermal delivery and anti-inflammatory activity...
2012: Skin Pharmacology and Physiology
Ping-Ping Liu, Yan-Li Shi, Yun-Xia Yang, Jin-Ming Liu, Jiao-Jiao Lin, Ya-Mei Jin
OBJECTIVE: To analyze the function of Sj34.9 gene, so as to provide the reference for future studies. METHODS: The Sj34.9 gene was knocked down in Schistosoma japonicum by RNA interference (RNAi), and the microarray was used to analyze the genes'expression of S. japonicum after Sj34.9 knocked down. RESULTS: A total of 378 genes expressed differently including 202 up-regulated genes and 176 down-regulated genes. The pathway analysis indicated that the genes expressed differently were mainly related to organelles, metabolism and signal transduction...
April 2012: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Shin-Hee Kim, Yoo-Sin Park, Jung Mogg Kim, Hae-Jeong Park, Min-Ho Lee, Hoon-Ki Park, Young-Jae Kim, Sam Hyun Cho, Leslie M Shaw, Juâ Seop Kang
AIM: Mosapride is a gastroprokinetic agent, a 5-HT4 receptor agonist and 5-HT3 receptor antagonist exhibiting no activity at dopamine D2, 5-HT1 and 5-HT2 receptors. This study was performed to compare basic pharmacokinetic (PK) characteristics of mosapride for Korean young adults and to evaluate the bioequivalence (BE) of two formulations of drugs mosapride. VOLUNTEERS AND METHODS: For pharmacokinetic and bioavailability of 5 mg mosapride tablets in healthy Korean adults, a randomized, two way, crossover bioequivalence study in 23 healthy Korean volunteers (M : F = 16 : 7) was conducted to compare bioavailability of two formulation of 5 mg mosapride citrate tablets, Moprid® (Chung Kun Dang Pharm Co...
July 2012: International Journal of Clinical Pharmacology and Therapeutics
S Negahdaripour, B K Horn
In this correspondence, we show how to recover the motion of an observer relative to a planar surface from image brightness derivatives. We do not compute the optical flow as an intermediate step, only the spatial and temporal brightness gradients (at a minimum of eight points). We first present two iterative schemes for solving nine nonlinear equations in terms of the motion and surface parameters that are derived from a least-squares fomulation. An initial pass over the relevant image region is used to accumulate a number of moments of the image brightness derivatives...
January 1987: IEEE Transactions on Pattern Analysis and Machine Intelligence
Javier Barboza, Luko Hilje, Julio Durón, Víctor Cartín, Marco A Calvo
A key neotropical pest of mahoganies (Swietenia spp.) and cedars (Cedrela spp.), the larva of Hypsipyla grandella (Zeller) commonly bores into the main shoot of these valuable timber species, causing forking of the stems. Therefore, it would be desirable to count upon a phagodeterrent and systemic product which could readily protect young tissues. Since crude extracts of common rue foliage (Ruta chalepensis L.) have phagodeterrent activity on H. grandella larva, a product was formulated by combining such an extract with a number of coadjuvants, and was assessed on 75-100 cm tall Spanish cedar (Cedrela odorata L...
March 2010: Revista de Biología Tropical
Michael Bur, Hanno Huwer, Leon Muys, Claus-Michael Lehr
BACKGROUND: Pulmonary cell cultures are increasingly used to predict in vivo drug absorption after inhalation, similar to intestinal cell culture models that have already been well established to predict oral drug absorption. In contrast to the intestinal barrier, however, the so-called air-blood barrier of the lung is covered only with a thin film of liquid, on which the aerosol particles are deposited. The aim of this study was to investigate the relevance of this apical liquid film on the drug absorption rate when deposited as a dry powder formulation on pulmonary epithelial cells in vitro...
June 2010: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Da-cheng Jiang, Jing-lei Xiao
OBJECTIVE: To compare eighteen samples of Forest frog's oviduct from different regions of northeast China, in order to fomulate the quality evaluation standard. METHODS: According to the documents, comparing the target constituent of Forest frog's oviduct, including the mositure, ash, protein, lipid and expansibility were analysed. RESULTS: It was similar to the chemical constituent in Forest frog's oviduct from different habitiat of northeast China...
October 2007: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
Busie B Maziya-Dixon, Isaac O Akinyele, Rasaki A Sanusi, Tunde E Oguntona, Sagary K Nokoe, Ellen W Harris
Vitamin A deficiency (VAD) is a serious and widespread public health problem in developing countries. We conducted a nationwide food consumption and nutrition survey in Nigeria to help fomulate strategies to address VAD, among other deficiencies. One objectives was to assess the vitamin A status of children <5 y old. A total of 6480 households with a mother and child <5 y old were randomly sampled. Blood samples were collected by venipuncture and processed to obtain serum for measurement of retinol concentration by HPLC...
August 2006: Journal of Nutrition
R P Radermecker, A J Scheen
FIELD ("Fenofibrate Intervention and Events Lowering in Diabetes") study compared the incidence of coronary and cardiovascular events in 4895 patients with type 2 diabetes treated with fenofibrate (micronized fomulation, 200 mg/day) and in 4900 patients treated with placebo. After a mean 5-year follow-up, the fenofibrate group did not have less coronary events (primary endpoint), neither present a significant reduction in cardiovascular or total mortality as compared to the placebo group. However, it had significantly less non-fatal myocardial infarctions and cardiovascular events in general as well as less coronary and total revascularization procedures (secondary endpoints)...
December 2005: Revue Médicale de Liège
Jan Möschwitzer, Rainer H Müller
High pressure homogenization can be employed to produce drug nanocrystals with a number of advantages, like improved solubility behaviors, better drug targeting or even increased mucoadhesiveness. To obtain a controlled drug delivery system it is necessary to transform the resulting nanosuspension into a solid dosage form. The present study shows the feasibility to use a mucoadhesive nanosuspension of poorly soluble hydrocortisone acetate produced by high pressure homogenization as layering dispersion in a fluidized bed process, followed by the application of an enteric coating to achieve a controlled drug release...
April 2006: European Journal of Pharmaceutics and Biopharmaceutics
C P Batra, K Raghavendra, T Adak, O P Singh, S P Singh, P K Mittal, M S Malhotra, R S Sharma, S K Subbarao
BACKGROUND AND OBJECTIVES: The main rural malaria vector Anopheles culicifacies has developed resistance to dichloro diphenyl trichloroethane (DDT), hexachloro cyclo hexane (HCH) and malathion in the state of Haryana in northern India. An alternative synthetic pyrethroid insecticide bifenthrin was therefore evaluated on mosquito nets against anopheline and culicine mosquitoes, in two villages Jagdishpur and Garh Mirakpur of Community Health Center (CHC) Badhkhalsa in district Sonipat, Haryana state...
January 2005: Indian Journal of Medical Research
Carlo Rossi, Giuseppe Fardella, Ione Chiappini, Luana Perioli, Claudia Vescovi, Maurizio Ricci, Stefano Giovagnoli, Stefania Scuota
Capreomycin (CS) is an antitubercular drug active against several Mycobacterium strains, in particular, against M. Avium. In spite of its activity, it is considered a second line drug because it can induce severe renal and hepatic damages when administered as free drug. However, it is possible to employ drug delivery systems, such as liposomes, to reduce the toxicity of the peptide without loss of its biological activity. For this purpose, appropriately validated time and money saving analytical methods are needed for a careful capreomycin dosage...
October 29, 2004: Journal of Pharmaceutical and Biomedical Analysis
Mark S Putt, Duncan Yu, Bruce E Kohut
PURPOSE: To examine the effect of three essential oil-containing dentifrice formulations with different zinc salts and concentrations on dental calculus formation in rats. MATERIALS AND METHODS: A total of 150 rats were randomly distributed into five litter and sex-matched groups of 30. They were maintained on a calculogenic diet and topically treated twice daily with undiluted dentifrices. Each experimental dentifrice formulation contained a zinc salt, a fixed combination of essential oils (i...
October 2002: American Journal of Dentistry
E Florence, C Dreezen, P Desmet, E Smets, K Fransen, B Vandercam, J Pelgrom, N Clumeck, R Colebunder
OBJECTIVES: To compare the efficacy, tolerability and safety of a ritonavir 400 mg/saquinavir hard gel fomulation 400 mg twice daily versus an indinavir 800 mg once every 8 h containing first-line protease inhibitor (PI) treatment regimen. METHODS: Open, randomized, multicentre clinical trial. PI-naive patients received either ritonavir/saquinavir and one nucleoside reverse transcriptase inhibitor (NRTI) or indinavir and two NRTIs. Intention-to-treat (ITT) and on-treatment (OT) analyses were performed...
December 2001: Antiviral Therapy
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