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https://www.readbyqxmd.com/read/27612392/a-mixed-treatment-meta-analysis-of-antibiotic-treatment-options-for-bovine-respiratory-disease-an-update
#1
REVIEW
A M O'Connor, C Yuan, J N Cullen, J F Coetzee, N da Silva, C Wang
Bovine respiratory disease is the most economically important disease of feedlot cattle in North America. Choice of antibiotic is a critical factor for producers and veterinarians. We previously published a mixed-treatment comparison meta-analysis that combined evidence from published trials and published estimates of comparative efficacy for 12 antibiotics registered for use in the USA. Some of the comparative efficacy estimates were based only on indirect evidence. Since the original review was published, new studies that provide direct evidence of comparative efficacy have been published...
September 15, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27527782/observations-on-macrolide-resistance-and-susceptibility-testing-performance-in-field-isolates-collected-from-clinical-bovine-respiratory-disease-cases
#2
Keith D DeDonder, Dayna M Harhay, Michael D Apley, Brian V Lubbers, Michael L Clawson, Gennie Schuller, Gregory P Harhay, Brad J White, Robert L Larson, Sarah F Capik, Jim E Riviere, Ted Kalbfleisch, Ronald K Tessman
The objectives of this study were; first, to describe gamithromycin susceptibility of Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni isolated from cattle diagnosed with bovine respiratory disease (BRD) and previously treated with either gamithromycin for control of BRD (mass medication=MM) or sham-saline injected (control=CON); second, to describe the macrolide resistance genes present in genetically typed M. haemolytica isolates; third, use whole-genome sequencing (WGS) to correlate the phenotypic resistance and genetic determinants for resistance among M...
August 30, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27171615/efficacy-of-gamithromycin-against-ornithobacterium-rhinotracheale-in-turkey-poults-pre-infected-with-avian-metapneumovirus
#3
Anneleen Watteyn, Mathias Devreese, Elke Plessers, Heidi Wyns, An Garmyn, Vishwanatha R A P Reddy, Frank Pasmans, An Martel, Freddy Haesebrouck, Patrick De Backer, Siska Croubels
Ornithobacterium rhinotracheale is an avian respiratory pathogen that affects turkeys. The objective of this study was to evaluate the clinical efficacy of gamithromycin (GAM) against O. rhinotracheale in turkeys. The birds were inoculated oculonasally with 10(8) colony-forming units (cfu) of O. rhinotracheale, preceded by infection with avian metapneumovirus. In addition to a negative (CONTR-) and a positive control group (CONTR+) there were two treated groups administered GAM (6 mg/kg) either subcutaneously (GAM SC) or orally (GAM PO) by administration as a single bolus at one-day post-bacterial infection (p...
October 2016: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/26964715/immunomodulatory-properties-of-gamithromycin-and-ketoprofen-in-lipopolysaccharide-challenged-calves-with-emphasis-on-the-acute-phase-response
#4
Elke Plessers, Heidi Wyns, Anneleen Watteyn, Bart Pardon, Siegrid De Baere, Stanislas U Sys, Patrick De Backer, Siska Croubels
Macrolide antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to be modulators of the innate immune response, irrespectively of their antimicrobial and anti-inflammatory actions. Therefore, it was our objective to evaluate whether the macrolide gamithromycin (GAM) and the NSAID ketoprofen (KETO) attenuate the acute-phase response in calves, and whether their combined administration is beneficial due to synergistic and/or additive effects. To this end, both drugs, as well as their combination, were studied in a previously developed inflammation model, i...
March 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/26679821/study-of-the-immunomodulatory-properties-of-gamithromycin-and-dexamethasone-in-a-lipopolysaccharide-inflammation-model-in-calves
#5
E Plessers, A Watteyn, H Wyns, B Pardon, P De Backer, S Croubels
The aim of this study was to define the in vivo immunomodulatory properties of the macrolide antibiotic gamithromycin in calves, with respect to the acute phase response. Additionally, the corticosteroid dexamethasone was included as a positive control immunomodulatory drug. Both drugs, as well as their combination,were studied in a previously developed inflammation model,which was initiated by an intravenous lipopolysaccharide (LPS) challenge (0.5 μg/kg body weight). Twenty-four 4-week-old male Holstein Friesian calves were randomized into four groups: no pharmacological treatment (n = 6) or a pharmacological treatment with gamithromycin (n= 6), dexamethasone (n= 6) or their combination (n= 6) 1 h prior to LPS administration...
December 2015: Research in Veterinary Science
https://www.readbyqxmd.com/read/26547885/modulation-by-gamithromycin-and-ketoprofen-of-in-vitro-and-in-vivo-porcine-lipopolysaccharide-induced-inflammation
#6
Heidi Wyns, Evelyne Meyer, Elke Plessers, Anneleen Watteyn, Thomas van Bergen, Stijn Schauvliege, Siegrid De Baere, Mathias Devreese, Patrick De Backer, Siska Croubels
The immunomodulatory properties of gamithromycin (GAM), ketoprofen (KETO) and their combination (GAM-KETO) were investigated after both in vitro and in vivo lipopolysaccharide (LPS)-induced inflammation. The influence of these drugs was measured on the production of prostaglandin E2 (PGE2) and the pro-inflammatory cytokines tumour necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β in both LPS-stimulated porcine peripheral blood mononuclear cells (PBMCs) and LPS-challenged pigs. Additionally, effects on the production of acute phase proteins (APPs), including pig major acute phase protein (pig-MAP) and C-reactive protein (CRP), as well as on the development of fever, pulmonary symptoms and sickness behaviour were investigated...
December 15, 2015: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/26441021/pharmacokinetics-and-pharmacodynamics-of-gamithromycin-in-pulmonary-epithelial-lining-fluid-in-naturally-occurring-bovine-respiratory-disease-in-multisource-commingled-feedlot-cattle
#7
K D DeDonder, M D Apley, M Li, R Gehring, D M Harhay, B V Lubbers, B J White, S F Capik, B KuKanich, J E Riviere, R K Tessman
The objectives of this study were to determine (i) whether an association exists between individual pharmacokinetic parameters and treatment outcome when feeder cattle were diagnosed with bovine respiratory disease (BRD) and treated with gamithromycin (Zactran(®) ) at the label dose and (ii) whether there was a stronger association between treatment outcome and gamithromycin concentration in plasma or in the pulmonary epithelial lining fluid (PELF) effect compartment. The study design was a prospective, blinded, randomized clinical trial utilizing three groups of 60 (362-592 lb) steers/bulls randomly allocated within origin to sham injection or gamithromycin mass medication...
April 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/26195808/pharmacokinetic-and-pharmacodynamic-properties-of-gamithromycin-in-turkey-poults-with-respect-to-ornithobacterium-rhinotracheale
#8
Anneleen Watteyn, Mathias Devreese, Siegrid De Baere, Heidi Wyns, Elke Plessers, Filip Boyen, Freddy Haesebrouck, Patrick De Backer, Siska Croubels
The macrolide gamithromycin (GAM) has the ability to accumulate in tissues of the respiratory tract. Consequently, GAM might be a suitable antibiotic to treat bacterial respiratory infections in poultry, such as Ornithobacterium rhinotracheale. As O. rhinotracheale infections are common in turkey flocks, the aim of this study was to determine the pharmacokinetic (PK) parameters of GAM in plasma, lung tissue, and pulmonary epithelial lining fluid (PELF) of turkeys and to correlate them with pharmacodynamic (PD) characteristics (PK/PD)...
September 2015: Poultry Science
https://www.readbyqxmd.com/read/25937131/development-and-validation-of-a-liquid-chromatography-tandem-mass-spectrometry-method-for-the-quantitative-determination-of-gamithromycin-in-animal-plasma-lung-tissue-and-pulmonary-epithelial-lining-fluid
#9
Siegrid De Baere, Mathias Devreese, Anneleen Watteyn, Heidi Wyns, Elke Plessers, Patrick De Backer, Siska Croubels
A sensitive and specific method for the quantitative determination of gamithromycin in animal plasma, lung tissue and pulmonary epithelial lining fluid (PELF) using liquid chromatography combined with heated electrospray ionization tandem mass spectrometry (LC-MS/MS) was developed. The sample preparation was rapid, straightforward and consisted of a deproteinization and phospholipid removal step using an Oasis(®) Ostro™ 96-well plate (chicken, turkey and calf plasma) or HybridSPE(®)-Phospholipid SPE cartridges (pig plasma and turkey lung tissue), while a liquid-liquid extraction with diethyl ether in alkaline medium was used for PELF of turkey poults...
June 12, 2015: Journal of Chromatography. A
https://www.readbyqxmd.com/read/25886555/synovial-fluid-pharmacokinetics-of-tulathromycin-gamithromycin-and-florfenicol-after-a-single-subcutaneous-dose-in-cattle
#10
Meredyth L Jones, Kevin E Washburn, Virginia R Fajt, Somchai Rice, Johann F Coetzee
BACKGROUND: Deep digital septic conditions represent some of the most refractory causes of severe lameness in cattle. The objective of this study was to determine the distribution of tulathromycin, gamithromycin and florfenicol into the synovial fluid of the metatarsophalangeal (MTP) joint of cattle after single subcutaneous administration of drug to evaluate the potential usefulness of these single-dose, long-acting antimicrobials for treating bacterial infections of the joints in cattle...
2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/25779793/synovial-fluid-pharmacokinetics-of-tulathromycin-gamithromycin-and-florfenicol-after-a-single-subcutaneous-dose-in-cattle
#11
Meredyth L Jones, Kevin E Washburn, Virginia R Fajt, Somchai Rice, Johann F Coetzee
BACKGROUND: Deep digital septic conditions represent some of the most refractory causes of severe lameness in cattle. The objective of this study was to determine the distribution of tulathromycin, gamithromycin and florfenicol into the synovial fluid of the metatarsophalangeal (MTP) joint of cattle after single subcutaneous administration of drug to evaluate the potential usefulness of these single-dose, long-acting antimicrobials for treating bacterial infections of the joints in cattle...
December 2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/25619521/efficacy-of-gamithromycin-for-the-treatment-of-foals-with-mild-to-moderate-bronchopneumonia
#12
RANDOMIZED CONTROLLED TRIAL
F Hildebrand, M Venner, S Giguère
BACKGROUND: Gamithromycin is active in vitro against the bacterial agents most commonly associated with bronchopneumonia in older foals. However, the clinical efficacy and safety of this drug have not been investigated. HYPOTHESIS: Gamithromycin is effective for the treatment of bronchopneumonia in foals. ANIMALS: One hundred and twenty-one foals on a farm endemic for infections caused by Rhodococcus equi. METHODS: In a controlled, randomized, and double blinded clinical trial, foals with ultrasonographic evidence of pulmonary abscesses (abscess score 8...
January 2015: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/25261417/macrolide-resistance-conferred-by-rrna-mutations-in-field-isolates-of-mannheimia-haemolytica-and-pasteurella-multocida
#13
Anders S Olsen, Ralf Warrass, Stephen Douthwaite
OBJECTIVES: To determine how resistance to macrolides is conferred in field isolates of Pasteurella multocida and Mannheimia haemolytica that lack previously identified resistance determinants for rRNA methylation, efflux and macrolide-modifying enzymes. METHODS: Isolates of P. multocida and M. haemolytica identified as being highly resistant (MICs >64 mg/L) to the macrolides erythromycin, gamithromycin, tilmicosin, tildipirosin and tulathromycin were screened by multiplex PCR for the previously identified resistance genes erm(42), msr(E) and mph(E)...
February 2015: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/25241389/gamithromycin-plasma-and-skin-pharmacokinetics-in-sheep
#14
COMPARATIVE STUDY
Michael Kellermann, Rose A Huang, Andrew B Forbes, Steffen Rehbein
This study assessed the plasma kinetics and skin/plasma concentration ratio of the azalide antibiotic gamithromycin (ZACTRAN(®), Merial) in sheep after a single subcutaneous administration at 6 mg/kg bodyweight. Gamithromycin concentrations in plasma samples collected at various intervals up to 21 days following treatment and metacarpal skin obtained from animals at two, five and ten days after treatment were determined by liquid chromatography-tandem mass spectrometry methods. After administration, gamithromycin was rapidly absorbed, and individual maximum plasma concentrations were observed within 6 hours post-dose...
October 2014: Research in Veterinary Science
https://www.readbyqxmd.com/read/25125397/performance-characterization-of-a-quantitative-liquid-chromatography-tandem-mass-spectrometric-method-for-12-macrolide-and-lincosamide-antibiotics-in-salmon-shrimp-and-tilapia
#15
Leslie C Dickson
This paper describes an extension and performance characterization of a quantitative confirmatory multi-residue liquid chromatography-tandem mass spectrometric method for residues of macrolide and lincosamide antibiotics, originally validated for application to bovine kidney tissues, to tissues of salmon, shrimp and tilapia. The 12 analytes include clindamycin, erythromycin A, gamithromycin, josamycin, lincomycin, neospiramycin 1, oleandomycin, pirlimycin, spiramycin 1, tildipirosin, tilmicosin and tylosin A...
September 15, 2014: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/24503775/overall-decrease-in-the-susceptibility-of-mycoplasma-bovis-to-antimicrobials-over-the-past-30-years-in-france
#16
Anne V Gautier-Bouchardon, Séverine Ferré, Dominique Le Grand, Agnès Paoli, Emilie Gay, François Poumarat
Mycoplasma (M.) bovis is frequently implicated in respiratory diseases of young cattle worldwide. Today, to combat M. bovis in Europe, only antimicrobial therapy is available, but often fails, leading to important economical losses. The antimicrobial susceptibility of M. bovis is not covered by antimicrobial resistance surveillance networks. The objectives of this study were to identify resistances that were acquired over the last 30 years in France and to determine their prevalence within contemporary strains...
2014: PloS One
https://www.readbyqxmd.com/read/24477473/field-studies-on-the-elimination-of-footrot-in-sheep-through-whole-flock-treatments-with-gamithromycin
#17
A B Forbes, H Strobel, I Stamphoj
No abstract text is available yet for this article.
February 8, 2014: Veterinary Record
https://www.readbyqxmd.com/read/24362004/targeted-antibiotic-treatment-of-lame-sheep-with-footrot-using-either-oxytetracycline-or-gamithromycin
#18
H Strobel, M Lauseker, A B Forbes
A study on parenteral antibiotic treatment in sheep footrot was conducted on 10 farms in southern Germany to obtain information on the efficacy of gamithromycin under practical use conditions compared with a positive control. On each farm, 20 (10 on one farm) lame sheep were clinically evaluated and divided into two groups. On day 1, sheep were treated once according to group with either long-acting oxytetracycline (OTC) at 20 mg/kg bodyweight or gamithromycin at 6 mg/kg; clinical responses were assessed 21 days later...
January 11, 2014: Veterinary Record
https://www.readbyqxmd.com/read/24331716/pharmacokinetics-of-gamithromycin-after-intravenous-and-subcutaneous-administration-in-pigs
#19
H Wyns, E Meyer, E Plessers, A Watteyn, S De Baere, P De Backer, S Croubels
The aim of this study was to investigate the pharmacokinetic properties of gamithromycin in pigs after an intravenous (i.v.) or subcutaneous (s.c.) bolus injection of 6 mg/kg body weight. The plasma concentrations of gamithromycin were determined using a validated high-performance liquid chromatography-tandem mass spectrometry method, and the pharmacokinetics were noncompartmentally analysed. Following i.v. administration, the mean area under the plasma concentration-time curve extrapolated to infinity (AUCinf) and the mean elimination half-life (t1/2λz) were 3...
February 2014: Research in Veterinary Science
https://www.readbyqxmd.com/read/23810743/in-vitro-pharmacodynamics-of-gamithromycin-against-mycoplasma-mycoides-subspecies-mycoides-small-colony
#20
John D Mitchell, Shan Goh, Quintin A McKellar, Declan J McKeever
Mycoplasma mycoides mycoides Small Colony (MmmSC) is the causative agent of contagious bovine pleuropneumonia (CBPP), which is responsible for major economic losses in sub-Saharan Africa. Current control relies on live attenuated vaccines, which are of limited efficacy, and antimicrobials are now being assessed as an alternative or adjunct to vaccination. The objective of this study was to determine the in vitro effector kinetics of the macrolide antimicrobial, gamithromycin, against MmmSC in artificial medium and adult bovine serum...
September 2013: Veterinary Journal
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