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https://www.readbyqxmd.com/read/29033962/unveiling-chloroplast-rna-editing-events-using-next-generation-small-rna-sequencing-data
#1
Nureyev F Rodrigues, Ana P Christoff, Guilherme C da Fonseca, Franceli R Kulcheski, Rogerio Margis
Organellar RNA editing involves the modification of nucleotide sequences to maintain conserved protein functions, mainly by reverting non-neutral codon mutations. The loss of plastid editing events, resulting from mutations in RNA editing factors or through stress interference, leads to developmental, physiological and photosynthetic alterations. Recently, next generation sequencing technology has generated the massive discovery of sRNA sequences and expanded the number of sRNA data. Here, we present a method to screen chloroplast RNA editing using public sRNA libraries from Arabidopsis, soybean and rice...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29027449/-soluble-expression-purification-and-structural-analysis-of-the-bhlh-transcription-factor-bmsage-of-bombyx-mori
#2
Huawei He, Shuguang Wei, Yejing Wang, Lina Liu, Zhenzhen Li, Peng Zhao, Huaipu Chang, Ping Zhao
Basic helix loop helix (bHLH) transcription factor plays an important role in biological processes. Bmsage is a class of bHLH transcription factor highly expressed in the silk gland of Bombyx mori, which is not only involved in the developmental regulation of the silk gland cells at the embryonic period, but also plays a crucial regulatory role during the synthesis of silk protein. However, currently, much of the property and structure of Bmsage is still remained unknown. To study the property, structure and biological role of Bmsage, we constructed several prokaryotic expression vectors of Bmsage fused with NusA, MBP, SUMO, Trx and His tags, respectively, then screened and determined the best soluble expression vector and condition of Bmsage in Escherichia coli combining with the induction temperature and IPTG concentration, and further purified the recombinant Bmsage by Ni-column affinity chromatography according to the established expression condition and characterized its secondary structure using circular dichroism spectra...
October 25, 2016: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29026837/binding-site-analysis-of-the-caenorhabditis-elegans-nr4a-nuclear-receptor-nhr-6-during-development
#3
Brandon Praslicka, Jeremy S Harmson, Joohyun Kim, Vittobai Rashika Rangaraj, Aikseng Ooi, Chris R Gissendanner
Members of the NR4A subfamily of nuclear receptors make up a highly conserved, functionally diverse group of transcription factors implicated in a multitude of cellular processes such as proliferation, differentiation, apoptosis, metabolism and DNA repair. The gene nhr-6, which encodes the sole C. elegans NR4A nuclear receptor homolog, has a critical role in organogenesis and regulates the development of the spermatheca organ system. Our previous work revealed that nhr-6 is required for spermatheca cell divisions in late L3 and early L4 and spermatheca cell differentiation during the mid L4 stage...
2017: Nuclear Receptor Research
https://www.readbyqxmd.com/read/29026377/developmental-screening-predictors-of-follow-up-adherence-in-primary-health-care
#4
Joanné Christine Schoeman, De Wet Swanepoel, Jeannie van der Linde
BACKGROUND: The importance of early identification for infants and young children with developmental delays is well established. Poor follow-up on referrals, however, undermines the effectiveness of early intervention programmes. OBJECTIVES: To identify factors, including text message reminders, that influence follow-up adherence for early intervention after developmental screening in primary health care. A secondary objective surveyed reasons for follow-up default...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29026089/a-large-scale-hearing-loss-screen-reveals-an-extensive-unexplored-genetic-landscape-for-auditory-dysfunction
#5
Michael R Bowl, Michelle M Simon, Neil J Ingham, Simon Greenaway, Luis Santos, Heather Cater, Sarah Taylor, Jeremy Mason, Natalja Kurbatova, Selina Pearson, Lynette R Bower, Dave A Clary, Hamid Meziane, Patrick Reilly, Osamu Minowa, Lois Kelsey, Glauco P Tocchini-Valentini, Xiang Gao, Allan Bradley, William C Skarnes, Mark Moore, Arthur L Beaudet, Monica J Justice, John Seavitt, Mary E Dickinson, Wolfgang Wurst, Martin Hrabe de Angelis, Yann Herault, Shigeharu Wakana, Lauryl M J Nutter, Ann M Flenniken, Colin McKerlie, Stephen A Murray, Karen L Svenson, Robert E Braun, David B West, K C Kent Lloyd, David J Adams, Jacqui White, Natasha Karp, Paul Flicek, Damian Smedley, Terrence F Meehan, Helen E Parkinson, Lydia M Teboul, Sara Wells, Karen P Steel, Ann-Marie Mallon, Steve D M Brown
The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains...
October 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29025854/how-to-use%C3%A2-hip-examination-and-ultrasound-in-newborns
#6
Yoshua Colyn Collins-Sawaragi, Kapila Jain
Developmental dysplasia of the hip (DDH) ranges from a clinically detectable dislocation of the hip to radiologically diagnosed hip abnormalities. It is caused by both antenatal and postnatal factors. The Neonatal and Infant Physical Examination Screening Programme recommends that newborns should undergo a hip ultrasound (USS) when risk factor or clinical features suggestive of DDH are present. The aim of hip ultrasonography is to detect DDH early and prevent late complications through early treatment. Here, we discuss how to use hip examination and USS in newborns...
October 12, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29022183/in-search-of-a-comprehensible-set-of-endpoints-for-the-routine-monitoring-of-neurotoxicity-in-vertebrates-sensory-perception-and-nerve-transmission-in-zebrafish-danio-rerio-embryos
#7
Daniel Stengel, Sarah Wahby, Thomas Braunbeck
In order to develop a test battery based on a variety of neurological systems in fish, three sensory systems (vision, olfaction, and lateral line) as well as nerve transmission (acetylcholine esterase) were analyzed in zebrafish (Danio rerio) embryos with respect to their suitability as a model for the screening of neurotoxic trace substances in aquatic ecosystems. As a selection of known or putative neurotoxic compounds, amidotrizoic acid, caffeine, cypermethrin, dichlorvos, 2,4-dinitrotoluene, 2,4-dichlorophenol, 4-nonylphenol, perfluorooctanoic acid, and perfluorooctane sulfonic acid were tested in the fish embryo test (OECD test guideline 236) to determine EC10 values, which were then used as maximum test concentration in subsequent neurotoxicity tests...
October 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29021281/survival-of-brca2-deficient-cells-is-promoted-by-gipc3-a-novel-genetic-interactor-of%C3%A2-brca2
#8
Xia Ding, Subha Philip, Betty K Martin, Yan Pang, Sandra Burkett, Deborah A Swing, Chinmayi Pamala, Daniel A Ritt, Ming Zhou, Deborah K Morrison, Xinhua Ji, Shyam K Sharan
BRCA2 loss-of-heterozygosity (LOH) is frequently observed in BRCA2-mutated tumors, but its bi-allelic loss causes embryonic lethality in mice and inhibits proliferation of normal somatic cells. Therefore, it remains unclear how loss of BRCA2 contributes to tumorigenesis. One possibility is that mutation in potential genetic interactors of BRCA2, such as TRP53, is required for cell survival/proliferation in the absence of BRCA2. In this study, using an insertional mutagenesis screen in mouse embryonic stem cells (mESC), we have identified GIPC3 (GAIP-interacting protein C-terminus 3) as a BRCA2 genetic interactor that contributes to survival of Brca2-null mESC...
October 11, 2017: Genetics
https://www.readbyqxmd.com/read/29018962/the-fetal-lung-to-liver-signal-intensity-ratio-on-magnetic-resonance-imaging-as-a-predictor-of-outcomes-from-isolated-congenital-diaphragmatic-hernia
#9
Masaya Yamoto, Teruo Iwazaki, Kasumi Takeuchi, Kyouhei Sano, Koji Fukumoto, Toshiaki Takahashi, Akiyoshi Nomura, Kei Ooyama, Akinori Sekioka, Yutaka Yamada, Naoto Urushihara
PURPOSE: We investigated the developmental changes in the unaffected contralateral lungs of patients with isolated left-sided congenital diaphragmatic hernia (CDH) using signal intensity ratios on prenatal magnetic resonance imaging (MRI) and determined whether these changes correlated with clinical outcomes. METHODS: We performed 47 fetal MRI screens on 30 patients with isolated left-sided CDH. A cohort of 88 fetuses was selected as the control. We calculated the lung-to-liver signal intensity ratio (LLSIR) using region of interest analysis and compared LLSIR between the groups and between those in the CDH group with good and poor prognoses...
October 10, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29016901/the-roles-of-the-sole-activator-type-auxin-response-factor-in-pattern-formation-of-marchantia-polymorpha
#10
Hirotaka Kato, Masaru Kouno, Mayuko Takeda, Hidemasa Suzuki, Kimitsune Ishizaki, Ryuichi Nishihama, Takayuki Kohchi
Cell division patterning is important to determine body shape in plants. Nuclear auxin signaling mediated by AUXIN RESPONSE FACTOR (ARF) transcription factors affects plant growth and development through regulation of cell division, elongation and differentiation. The evolutionary origin of the ARF-mediated pathway dates back to at least the common ancestor of bryophytes and other land plants. The liverwort Marchantia polymorpha has three phylogenetically distinct ARFs: MpARF1, the sole 'activator' ARF; and MpARF2 and MpARF3, two 'repressor' ARFs...
July 20, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28993268/nanotoxicological-and-teratogenic-effects-a-linkage-between-dendrimer-surface-charge-and-zebrafish-developmental-stages
#11
Maria Natalia Calienni, Daniela Agustina Feas, Daniela Edith Igartúa, Nadia Silvia Chiaramoni, Silvia Del Valle Alonso, Maria Jimena Prieto
This article reports novel results about nanotoxicological and teratogenic effects of the PAMAM dendrimers DG4 and DG4.5 in zebrafish (Danio rerio). Zebrafish embryos and larvae were used as a rapid, high-throughput, cost-effective whole-animal model. The objective was to provide a more comprehensive and predictive developmental toxicity screening of DG4 and DG4.5 and test the influence of their surface charge. Nanotoxicological and teratogenic effects were assessed at developmental, morphological, cardiac, neurological and hepatic level...
October 6, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28992658/-the-pl%C3%A3-ner-model-for-the-school-entry-screening-is-a-role-model-for-the-future
#12
Josef Weigl
Background The Plöner Model is a stepwise-selective model, similar to the one practised in all of Bavaria since 2008. It was already developed in 2002/2003 for the school entry screening and has been in use since then. Such models are intermittently criticized since not each child is seen by a doctor. Methods The procedure and data of the Plöner Model are analyzed and put into a wider context within Germany and beyond. The current programs in place are therefore categorized into 3 groups and compared with regard to public heath ethics criteria...
October 9, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28992657/-competing-validity-of-developmental-diagnostic-in-school-entry-examination-results-of-a-census-in-an-upper-bavarian-district
#13
Heribert Stich, Kristin Maria Schlinkmann, Rafael Mikolajczyk
Aim of the study Evaluation of the concurrent validity of a modified Bavarian model (BM) compared to the social-paediatric screening of developmental status for school entry (SOPESS) as a reference tool. Methods A total of 407 preschoolers to be enrolled for the school year 2015 in an Upper Bavarian District were examined by BM and SOPESS. As a measure of the concurrent validity, the Kappa by Cohen (ĸ) was used. Results The agreement of both instruments was moderate and was less pronounced for single dimensions than globally...
October 9, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28991358/an-expanded-view-of-joint-attention-skill-engagement-and-language-in-typical-development-and-autism
#14
Lauren B Adamson, Roger Bakeman, Katharine Suma, Diana L Robins
This study provides an expanded view of joint attention and its relation to expressive language development. A total of 144 toddlers (40 typically developing, 58 with autism spectrum disorder [ASD], 46 with developmental delay [DD]) participated at 24 and 31 months. Toddlers who screened positive for ASD risk, especially those subsequently diagnosed with ASD, had poorer joint attention skills, joint engagement during parent-toddler interaction, and expressive language. Findings highlight the dynamic relation between joint attention and language development...
October 9, 2017: Child Development
https://www.readbyqxmd.com/read/28990963/terrible-twos-or-early-signs-of-psychopathology-developmental-patterns-in-early-identified-preschoolers-with-cochlear-implants-compared-with-hearing-controls
#15
Anouk P Netten, Carolien Rieffe, Lizet Ketelaar, Wim Soede, Kenneth D Gadow, Johan H M Frijns
OBJECTIVE: Cochlear implants (CIs) have dramatically improved the lives of children who are deaf or hard of hearing; however, little is known about its implications for preventing the development of psychiatric symptoms in this at-risk population. This is the first longitudinal study to examine the early manifestation of emotional and behavioral disorders and associated risk and protective factors in early identified preschoolers with CIs compared with hearing peers. DESIGN: Participants were 74 children with CIs and 190 hearing controls between ages 1 and 5 years (mean age, 3...
October 4, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28990447/psychotic-like-experiences-in-help-seeking-adolescents-dimensional-exploration-and-association-with-different-forms-of-bullying-victimization-a-developmental-social-psychiatry-perspective
#16
Gennaro Catone, Roberta Marotta, Simone Pisano, Belinda Lennox, Marco Carotenuto, Antonella Gritti, Antonio Pascotto, Matthew R Broome
BACKGROUND: Psychotic-like experiences (PLEs) are common in the general population and increase the risk of psychotic disorders. Adolescents are a high-risk group of this condition. Stressful events, such as bullying, have a role in the onset of PLEs. This study has several aims: (1) to assess PLEs in adolescents seeking help from a Child and Adolescent Mental Health Service, (2) to assess the association of PLEs with specific bullying victimization and (3) to assess difference in PLEs and victimizations by sex and age...
October 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28982961/mechanisms-in-endocrinology-maternal-thyroid-dysfunction-during-pregnancy-and-behavioural-and-psychiatric-disorders-of-children-a-systematic-review
#17
REVIEW
Dagnachew Muluye Fetene, Kim S Betts, Rosa Alati
BACKGROUND: Maternal thyroid dysfunction during pregnancy may lead to persistent neurodevelopmental disorders in the offspring appearing in later life. This study aimed to review the available evidence concerning the relationship between maternal thyroid status during pregnancy and offspring behavioural and psychiatric disorders. METHODS: Systematic electronic database searches were conducted using PubMed, Embase, PsycNET, Scopus, Google Scholar and Cochrane library...
November 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28982529/implementation-of-early-diagnosis-and-intervention-guidelines-for-cerebral-palsy-in-a-high-risk-infant-follow-up-clinic
#18
Rachel Byrne, Garey Noritz, Nathalie L Maitre
BACKGROUND: Cerebral palsy is the most common physical disability in childhood, and is mostly diagnosed after age 2 years. Delays in diagnosis can have negative long-term consequences for children and parents. New guidelines for early cerebral palsy diagnosis and intervention were recently published, after systematic review of the evidence by international multidisciplinary experts aiming to decrease age at diagnosis. The current study tested the feasibility of implementing these guidelines in an American clinical setting...
August 30, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28979165/validation-of-autism-spectrum-disorder-diagnoses-recorded-in-the-clinical-practice-research-datalink-1990-2014
#19
Katrina Wilcox Hagberg, Susan S Jick
BACKGROUND: Prior studies have reported that the validity of autism spectrum disorder (ASD) diagnoses recorded in the Clinical Practice Research Datalink (CPRD) was high; however, diagnostic criteria and screening practices have changed since the last study was published in 2004. OBJECTIVES: 1) To calculate the positive predictive value (PPV) of ASD diagnoses recorded in the CPRD compared to original medical records and 2) to describe characteristics of cases and use of clinical codes that support the ASD diagnosis as recorded in the electronic data by general practitioners over time...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28975691/gut-feelings-studying-enteric-nervous-system-development-function-and-disease-in-the-zebrafish-model-system
#20
REVIEW
Julia Ganz
The enteric nervous system (ENS) is the largest part of the peripheral nervous system and is entirely neural crest derived. It provides the intrinsic innervation of the gut controlling different aspects of gut function, such as motility. In this review, we will discuss key points of zebrafish ENS development, genes and signaling pathways regulating ENS development as well as contributions of the zebrafish model system to better understand ENS disorders. During their migration, enteric progenitor cells display a gradient of developmental states based on their proliferative and migratory characteristics and show spatio-temporal heterogeneity based on gene expression patterns...
October 4, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
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