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https://www.readbyqxmd.com/read/27894286/the-family-experiences-of-in-hospital-care-questionnaire-in-severe-traumatic-brain-injury-fecq-tbi-a-validation-study
#1
Audny Anke, Unn Sollid Manskow, Oddgeir Friborg, Cecilie Røe, Cathrine Arntzen
BACKGROUND: Family members are important for support and care of their close relative after severe traumas, and their experiences are vital health care quality indicators. The objective was to describe the development of the Family Experiences of in-hospital Care Questionnaire for family members of patients with severe Traumatic Brain Injury (FECQ-TBI), and to evaluate its psychometric properties and validity. METHODS: The design of the study is a Norwegian multicentre study inviting 171 family members...
November 28, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27889718/parents-evaluation-of-developmental-status-peds-in-screening-for-developmental-delay-in-thai-children-aged-18-30-months
#2
Pornchanok Wantanakorn, Khemsuang Sawangworachart, Rawiwan Roongpraiwan, Jariya Chuthapisith
The PEDS-Thai is a developmental screening tool. We studied its diagnostic performance among 137 Thai children (48.9%) aged 18-30 month. It had a sensitivity of 92.8% and a specificity of 49.2%. The positive and negative likelihood ratios were 1.82 and 0.14 when compared with clinical diagnosis and diagnostic tool, the Mullen Scales of Early Learning (Mullen, 1995).
November 5, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27884602/a-data-driven-weighting-scheme-for-multivariate-phenotypic-endpoints-recapitulates-zebrafish-developmental-cascades
#3
Guozhu Zhang, Kyle R Roell, Lisa Truong, Robert L Tanguay, David M Reif
Zebrafish have become a key alternative model for studying health effects of environmental stressors, partly due to their genetic similarity to humans, fast generation time, and the efficiency of generating high-dimensional systematic data. Studies aiming to characterize adverse health effects in zebrafish typically include several phenotypic measurements (endpoints). While there is a solid biomedical basis for capturing a comprehensive set of endpoints, making summary judgments regarding health effects requires thoughtful integration across endpoints...
November 21, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27884203/a-system-dynamics-model-of-clinical-decision-thresholds-for-the-detection-of-developmental-behavioral-disorders
#4
R Christopher Sheldrick, Dominic J Breuer, Razan Hassan, Kee Chan, Deborah E Polk, James Benneyan
BACKGROUND: Clinical decision-making has been conceptualized as a sequence of two separate processes: assessment of patients' functioning and application of a decision threshold to determine whether the evidence is sufficient to justify a given decision. A range of factors, including use of evidence-based screening instruments, has the potential to influence either or both processes. However, implementation studies seldom specify or assess the mechanism by which screening is hypothesized to influence clinical decision-making, thus limiting their ability to address unexpected findings regarding clinicians' behavior...
November 25, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27883195/the-use-of-cardiac-orienting-responses-as-an-early-and-scalable-biomarker-of-alcohol-related-neurodevelopmental-impairment
#5
Diego A Mesa, Julie A Kable, Claire D Coles, Kenneth Lyons Jones, Lyubov Yevtushok, Yaroslav Kulikovsky, Wladimir Wertelecki, Todd P Coleman, Christina D Chambers
BACKGROUND: Considered the leading cause of developmental disabilities worldwide, fetal alcohol spectrum disorders (FASD) are a global health problem. To take advantage of neural plasticity, early identification of affected infants is critical. The cardiac orienting response (COR) has been shown to be sensitive to the effects of prenatal alcohol exposure and is an inexpensive, easy to administer assessment tool. The purpose of this study was to evaluate the COR effectiveness in assessing individual risk of developmental delay...
November 24, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27881449/primary-cilia-and-mammalian-hedgehog-signaling
#6
Fiona Bangs, Kathryn V Anderson
It has been a decade since it was discovered that primary cilia have an essential role in Hedgehog (Hh) signaling in mammals. This discovery came from screens in the mouse that identified a set of genes that are required for both normal Hh signaling and for the formation of primary cilia. Since then, dozens of mouse mutations have been identified that disrupt cilia in a variety of ways and have complex effects on Hedgehog signaling. Here, we summarize the genetic and developmental studies used to deduce how Hedgehog signal transduction is linked to cilia and the complex effects that perturbation of cilia structure can have on Hh signaling...
November 23, 2016: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/27879346/the-zebrafish-frozen-mutant-is-a-model-for-human-myopathy-associated-with-mutation-of-the-unconventional-myosin-myo18b
#7
Ritika Gurung, Yosuke Ono, Sarah Baxendale, Samantha Lin Chiou Lee, Steven Moore, Meredith Calvert, Philip W Ingham
MYOSIN 18B is an unconventional myosin that has been implicated in tumour progression in humans. In addition, loss-of-function mutations of the MYO18B gene have recently been identified in several patients exhibiting symptoms of nemaline myopathy. In mouse, mutation of Myo18B results in early developmental arrest associated with cardiomyopathy, precluding analysis of its effects on skeletal muscle development. The zebrafish, frozen (fro) mutant was identified as one of a group of immotile mutants in the 1996 Tübingen genetic screen...
November 22, 2016: Genetics
https://www.readbyqxmd.com/read/27876705/genome-wide-gain-of-function-screen-for-genes-that-induce-epithelial-to-mesenchymal-transition-in-breast-cancer
#8
Dubravka Škalamera, Mareike Dahmer-Heath, Alexander J Stevenson, Cletus Pinto, Esha T Shah, Sheena M Daignault, Nur Akmarina B M Said, Melissa Davis, Nikolas K Haass, Elizabeth D Williams, Brett G Hollier, Erik W Thompson, Brian Gabrielli, Thomas J Gonda
Epithelial to mesenchymal transition (EMT) is a developmental program that has been implicated in progression, metastasis and therapeutic resistance of some carcinomas. To identify genes whose overexpression drives EMT, we screened a lentiviral expression library of 17000 human open reading frames (ORFs) using high-content imaging to quantitate cytoplasmic vimentin. Hits capable of increasing vimentin in the mammary carcinoma-derived cell line MDA-MB-468 were confirmed in the non-tumorigenic breast-epithelial cell line MCF10A...
August 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27876688/online-concerns-of-parents-suspecting-autism-spectrum-disorder-in-their-child-content-analysis-of-signs-and-automated-prediction-of-risk
#9
Ayelet Ben-Sasson, Elad Yom-Tov
BACKGROUND: Online communities are used as platforms by parents to verify developmental and health concerns related to their child. The increasing public awareness of autism spectrum disorders (ASD) leads more parents to suspect ASD in their child. Early identification of ASD is important for early intervention. OBJECTIVE: To characterize the symptoms mentioned in online queries posed by parents who suspect that their child might have ASD and determine whether they are age-specific...
November 22, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27876249/synthesis-anti-proliferative-activity-sar-study-and-preliminary-in-vivo-toxicity-study-of-substituted-n-n-bis-arylmethyl-benzimidazolium-salts-against-a-panel-of-non-small-cell-lung-cancer-cell-lines
#10
Kerri L Shelton, Michael A DeBord, Patrick O Wagers, Marie R Southerland, Travis M Williams, Nikki K Robishaw, Leah P Shriver, Claire A Tessier, Matthew J Panzner, Wiley J Youngs
A series of N,N'-bis(arylmethyl)benzimidazolium salts have been synthesized and evaluated for their in vitro anti-cancer activity against select non-small cell lung cancer cell lines to create a structure activity relationship profile. The results indicate that hydrophobic substituents on the salts increase the overall anti-proliferative activity. Our data confirms that naphthylmethyl substituents at the nitrogen atoms (N(1)(N(3))) and highly lipophilic substituents at the carbon atoms (C(2) and C(5)(C(6))) can generate benzimidazolium salts with anti-proliferative activity that is comparable to that of cisplatin...
November 5, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27876079/copenhagen-infant-mental-health-project-study-protocol-for-a-randomized-controlled-trial-comparing-circle-of-security-parenting-and-care-as-usual-as-interventions-targeting-infant-mental-health-risks
#11
Mette Skovgaard Væver, Johanne Smith-Nielsen, Theis Lange
BACKGROUND: Infant mental health is a significant public health issue as early adversity and exposure to early childhood stress are significant risk factors that may have detrimental long-term developmental consequences for the affected children. Negative outcomes are seen on a range of areas such as physical and mental health, educational and labor market success, social network and establishing of family. Secure attachment is associated with optimal outcomes in all developmental domains in childhood, and both insecure and disorganized attachment are associated with a range of later problems and psychopathologies...
November 22, 2016: BMC Psychology
https://www.readbyqxmd.com/read/27875746/de-novo-and-inherited-scn8a-epilepsy-mutations-detected-by-gene-panel-analysis
#12
Kameryn M Butler, Cristina da Silva, Yuval Shafir, James D Weisfeld-Adams, John J Alexander, Madhuri Hegde, Andrew Escayg
OBJECTIVES: To determine the incidence of pathogenic SCN8A variants in a cohort of epilepsy patients referred for clinical genetic testing. We also investigated the contribution of SCN8A to autism spectrum disorder, intellectual disability, and neuromuscular disorders in individuals referred for clinical genetic testing at the same testing laboratory. METHODS: Sequence data from 275 epilepsy panels screened by Emory Genetics Laboratory were reviewed for variants in SCN8A...
November 6, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27875541/new-perspective-on-impact-of-folic-acid-supplementation-during-pregnancy-on-neurodevelopment-autism-in-the-offspring-children-a-systematic-review
#13
Yunfei Gao, Chao Sheng, Ri-Hua Xie, Wen Sun, Elizabeth Asztalos, Diane Moddemann, Lonnie Zwaigenbaum, Mark Walker, Shi Wu Wen
It has been conclusively established that folic acid supplementation prior to and during early pregnancy (up to 12 weeks of gestation) can prevent neural tube defects (NTDs). We hypothesized that folate effects may extend from neuro-structural defects to alterations in neuro-behavioural and emotional skills including autism spectrum disorders (ASDs) and other developmental disorders. The objective of this review was to comprehensively evaluate evidence on the impact of folic acid on neurodevelopment other than NTDs...
2016: PloS One
https://www.readbyqxmd.com/read/27874270/neurodevelopmental-disorders-are-highly-over-represented-in-children-with-obesity-a-cross-sectional-study
#14
Elisabet Wentz, Anna Björk, Jovanna Dahlgren
OBJECTIVE: To investigate prevalence of neurodevelopmental disorders in children with obesity and to compare body mass index (BMI) and metabolic profile in the children. METHODS: Seventy-six children (37 girls, 39 boys) were consecutively recruited from a university outpatient clinic specialized in severe obesity. Neurodevelopmental disorders including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and developmental coordination disorder (DCD) were assessed using interviews and questionnaires...
November 22, 2016: Obesity
https://www.readbyqxmd.com/read/27872628/proteomics-and-ssh-analyses-of-ala-promoted-fruit-coloration-and-evidence-for-the-involvement-of-a-mads-box-gene-mdmads1
#15
Xinxin Feng, Yuyan An, Jie Zheng, Miao Sun, Liangju Wang
Skin color is a key quality attribute of fruits and how to improve fruit coloration has long been a major concern. 5-Aminolevulinic acid (ALA), a natural plant growth regulator, can significantly increase anthocyanin accumulation in fruit skin and therefore effectively improve coloration of many fruits, including apple. However, the molecular mechanism how ALA stimulates anthocyanin accumulation in fruit skin remains unknown. Here, we investigated the impact of ALA on apple skin at the protein and mRNA levels...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27869673/3d-visualization-of-developmental-toxicity-of-2-4-6-trinitrotoluene-in-zebrafish-embryogenesis-using-light-sheet-microscopy
#16
Juneyong Eum, Jina Kwak, Hee Joung Kim, Seoyoung Ki, Kooyeon Lee, Ahmed A Raslan, Ok Kyu Park, Md Ashraf Uddin Chowdhury, Song Her, Yun Kee, Seung-Hae Kwon, Byung Joon Hwang
Environmental contamination by trinitrotoluene is of global concern due to its widespread use in military ordnance and commercial explosives. Despite known long-term persistence in groundwater and soil, the toxicological profile of trinitrotoluene and other explosive wastes have not been systematically measured using in vivo biological assays. Zebrafish embryos are ideal model vertebrates for high-throughput toxicity screening and live in vivo imaging due to their small size and transparency during embryogenesis...
November 17, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27867005/temporal-expression-of-cd184-cxcr4-and-cd171-l1cam-identifies-distinct-early-developmental-stages-of-human-retinal-ganglion-cells-in-embryonic-stem-cell-derived-retina
#17
J G Aparicio, H Hopp, A Choi, J Mandayam Comar, V C Liao, N Harutyunyan, T C Lee
Human retinal ganglion cells (RGCs) derived from pluripotent stem cells (PSCs) have anticipated value for human disease study, drug screening, and therapeutic applications; however, their full potential remains underdeveloped. To characterize RGCs in human embryonic stem cell (hESC) derived retinal organoids we examined RGC markers and surface antigen expression and made comparisons to human fetal retina. RGCs in both tissues exhibited CD184 and CD171 expression and distinct expression patterns of the RGC markers BRN3 and RBPMS...
November 17, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27866823/relative-risk-and-incidence-for-developmental-dysplasia-of-the-hip
#18
Virginie Pollet, Vanessa Percy, Heather J Prior
OBJECTIVE: To determine the incidence and associated risk factors of developmental dysplasia of the hip (DDH) in a modern population without universal screening. STUDY DESIGN: Children with DDH were identified from the Manitoba Centre for Health Policy's Data Repository by the use of International Classification of Diseases diagnosis codes as well as physician billing tariffs for surgical procedures for DDH for all children born between 1995 and 2012. To identify the outpatient-treated patients, ultrasound scans and radiographic imaging for DDH were reviewed for 2004-2012...
November 18, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27866316/epidemiology-of-developmental-dysplasia-of-the-hip-within-the-uk-refining-the-risk-factors
#19
Timothy Woodacre, Thomas Ball, Peter Cox
PURPOSE: The epidemiology and risk factors for developmental dysplasia of the hip (DDH) are still being refined. We investigated the local epidemiology of DDH in order to define incidence, identify risk factors, and refine our policy on selective ultrasound screening. METHODS: With a cohort study design, data were prospectively recorded on all live births in our region from January 1998 to December 2008. We compared data on babies treated for DDH with data for all other children...
November 19, 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27863382/an-early-screening-biomarker-of-endometrial-carcinoma-ngal-is-associated-with-epithelio-mesenchymal-transition
#20
Ting Li, Li Yu, Jia Wen, Qinping Liao, Zhaohui Liu
neutrophilgelatinase-associated lipocalin is currently one of the most interesting and enigmatic proteins involved in the development of malignancies. In this study, we found that the expression of neutrophilgelatinase-associated lipocalin was up-regulated in endometrial cancer tissues and cell lines, significantly increased in early-grade ones, suggesting it may serve as a biomarker for early-stage screening for endometrial carcinoma. Moreover, neutrophilgelatinase-associated lipocalin was up-regulated in Ishikawa cells under going epithelio-mesenchymal transition induced by epidermal growth factor (5 ng/ml)...
November 14, 2016: Oncotarget
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