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https://www.readbyqxmd.com/read/29218624/motivation-for-launching-a-cancer-metastasis-inhibition-cmi-program
#1
REVIEW
Jill M Pulley, Rebecca N Jerome, Martin L Ogletree, Gordon R Bernard, Robert R Lavieri, Nicole M Zaleski, Charles C Hong, Jana K Shirey-Rice, Carlos L Arteaga, Ingrid A Mayer, Kenneth J Holroyd, Rebecca S Cook
Metastatic cancers impose significant burdens on patients, affecting quality of life, morbidity, and mortality. Even during remission, microscopic metastases can lurk, but few therapies directly target tumor cell metastasis. Agents that interfere with this process would represent a new paradigm in cancer management, changing the 'waiting game' into a time of active prevention. These therapies could take multiple forms based on the pathways involved in the metastatic process. For example, a phenome-wide association study showed that a single nucleotide polymorphism in the gene TBXA2R is associated with increased metastasis in multiple primary cancers (P = 0...
December 7, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/29218244/exosomal-tgf-%C3%AE-1-is-correlated-with-lymphatic-metastasis-of-gastric-cancers
#2
Er-Yen Yen, Shi-Chuen Miaw, Jhang-Sian Yu, I-Rue Lai
Exosomes are nano-vesicles transporting bioactive material between cells. This study explored the prognostic association of exosomal TGF-β1 with lymph node (LN) metastasis of gastric cancer (GC). TGF-β1 expressions in the exosomes isolated from the gastroepiploic veins of 61 GC patients analyzed by ELISA. The regulatory T (Treg) cells in celiac LNs of gastric cancer analyzed by immunohistochemistry. Exosomal TGF-β1 expression and the ratio of Treg cells in draining LNs were both significantly associated with pathological stages and LN metastasis of gastric cancer...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29218108/the-synergistic-effect-of-esophageal-squamous-cell-carcinoma-kyse150-cells-and-m2-macrophages-on-lymphatic-endothelial-cells
#3
Miao-Miao Sun, Lu-Lu He, Hong-Xin Zhang, Na Wei, Wei-Wei Wang, Guo-Zhong Jiang, Zheng-Yang Wang, Dong-Mei Zhao, Kui-Sheng Chen
Objective: This study aimed to investigate whether tumor-associated macrophages (TAMs) and esophageal squamous cell carcinoma (ESCC) cells could synergistically influence the generation of lymphatic vessels via the VEGF-C/VEGFR-3 signaling pathway and to address its mechanism. Methods: M2 macrophages were sorted with immunomagnetic beads and induced in vitro. VEGF-C siRNA plasmids were constructed and transfected into M2 macrophages and the ESCC cell line KYSE150. Different conditioned culture media before and after transfection were collected and classified into different groups for culturing ESCC-associated lymphatic endothelial cells (ESCC-LECs)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29218079/vegf-c-mediated-enhancement-of-lymphatic-drainage-reduces-intestinal-inflammation-by-regulating-il-9-il-17-balance-and-improving-gut-microbiota-in-experimental-chronic-colitis
#4
Xiaolei Wang, Jin Zhao, Li Qin
BACKGROUND: Inflammation-associated lymphangiogenesis (IAL) induced by vascular endothelial growth factor (VEGF)-C/VEGF receptor-3 (VEGFR-3) pathway plays a crucial role in chronic intestinal inflammation. This study aimed to investigate the effects of VEGF-C mediated enhancement of lymphatic drainage on the intestinal inflammation in experimental chronic colitis (CC) and the potential mechanism was explored. METHODS: Mouse CC model was established by three cycles of 2% DSS administration for 5 days following water administration for 5 days...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217440/endolymphatic-balloon-occluded-retrograde-abdominal-lymphangiography-boral-and-embolization-borale-for-the-diagnosis-and-treatment-of-chylous-ascites-technique-and-experience-in-three-patients
#5
Ravi N Srinivasa, Joseph J Gemmete, Matthew L Osher, Jeffrey Forris Beecham Chick
PURPOSE: To describe endolymphatic balloon-occluded retrograde abdominal lymphangiography (BORAL) and embolization (BORALE) for diagnosis and treatment of chylous ascites in patients with previously unidentifiable leakage site or failed lymphatic embolization. MATERIALS AND METHODS: Two (66%) men and one (33%) woman with mean age of 52 years (range: range: 14-79 years) presented with chylous ascites and underwent BORAL or BORALE between March 2016 and February 2017...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29217436/endolymphatic-thoracic-duct-stent-graft-reconstruction-for-chylothorax-approach-technical-success-safety-and-short-term-outcomes
#6
Rajiv Srinivasa, Jeffrey Forris Beecham Chick, Anthony Hage, Joseph J Gemmete, Douglas C Murrey, Ravi N Srinivasa
PURPOSE: To report approach, technical success, safety, and short-term outcomes of thoracic duct stent-graft reconstruction for the treatment of chylothorax. MATERIALS AND METHODS: Two patients, one (50%) male and one (50%) female, with mean age of 38 years (range: 16-59 years) underwent endolymphatic thoracic duct stent-grafting between September 2016 and July 2017. Patients had radiographic left-sided chylothoraces (n=2) from idiopathic causes (n=1) and heart transplantation (n=1)...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29217071/psychosocial-impact-of-vascular-anomalies-on-children-and-their-families
#7
REVIEW
Alexandra G Espinel, Nancy M Bauman
Vascular anomalies are divided into tumors and malformations based on their clinical and cytologic attributes. Vascular malformations are further subcategorized as low-flow lymphatic, venous, capillary, or mixed lesions and as high-flow arteriovenous malformations. Treatment is reserved for vascular anomalies that are symptomatic or cosmetically disfiguring, and surgical and nonsurgical treatment options are widely varied with variable outcomes.
February 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29217060/multidisciplinary-approach-to-the-management-of-lymphatic-malformations-of-the-head-and-neck
#8
REVIEW
Milton Waner, Teresa M O
Lymphatic malformations (LMs) occur in 2.8 to 5 per 100,000 live births. Most involve the head and neck and they are equally common in men and women. They are developmental anomalies of unknown cause, although recent evidence suggests that an upregulation of the mammalian target of rapamycin (mTOR) pathway may be a causal factor leading to the overproduction of abnormal lymph vessels. These vessels are likely dilated lymphatic sacs sequestered from the lymphatic and venous systems. This overproduction results in the accumulation of lymph in dilated cystic spaces, which in turn results in the clinical features of an LM...
February 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29217059/new-frontiers-in-our-understanding-of-lymphatic-malformations-of-the-head-and-neck-natural-history-and-basic-research
#9
REVIEW
Jonathan A Perkins
The future of head and neck lymphatic malformation (HNLM) evaluation and treatment is changing because of 2 decades of clinical research and recent basic science investigation. Basic science investigation using cellular biology and molecular genetics has revealed the genetic cause of some HNLMs, which has created the possibility of medical treatment specific to HNLM. This article summarizes the clinical and basic science research that will likely influence the future of HNLM assessment and treatment.
February 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29217055/outcome-measurement-for-vascular-malformations-of-the-head-and-neck
#10
REVIEW
Sophie E R Horbach, Amber P M Rongen, Teresa M O, Milton Waner, Chantal M A M van der Horst
Vascular malformations are congenital anomalies of the vascular and/or lymphatic system that affect the head and neck region. The most common treatment options are sclerotherapy, laser therapy, surgery, and embolization. Because vascular malformations are variable in type, size, extent, and location, it is a challenge to select methods for evaluation of treatment outcome. Without standardized outcome reporting, it is difficult to compare and combine scientific evidence to support therapeutic decision making...
February 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29216739/lymphatic-drainage-efficiency-a-new-parameter-of-lymphatic-function
#11
Georgia Keramida, Emma Wroe, Nicola Winterman, Mark Aplin, A Michael Peters
Background Following convection from blood capillaries, plasma proteins are transported to loco-regional lymph nodes in two stages: first, uptake into peripheral lymphatics, and second, transport to nodes. Purpose To introduce a new parameter of lymphatic function that quantifies stage 2 - lymphatic drainage efficiency (LDE). Material and Methods Percentage injected activity (IIQ) in ilio-inguinal nodes 150 min following subcutaneous foot web-space injection of Tc-99 m-nanocolloid was measured in 102 patients undergoing lymphoscintigraphy using a method in which a standard is placed by image guidance over the nodes...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29215294/structure-reconstruction-of-lyp-1-lc-lyp-1-coupling-by-amide-bond-inspires-the-brain-metastatic-tumor-targeted-drug-delivery
#12
Xiaoyu Zhang, Fei Wang, Qing Shen, Cao Xie, Yu Liu, Jun Pan, Weiyue Lu
The stability and binding affinity of targeting ligands play important roles in active targeting drug delivery. Herein LyP-1 peptide was used as a model peptide to investigate chemical-biology-based strategies in the design of peptide ligands for active targeting. LyP-1, a short peptide cyclized with a disulfide bond, can specifically bind to tumor cells and tumor lymphatics through the interaction with cell-surface protein p32/gC1qR. Lc(LyP-1), with the same sequence of LyP-1 by amide coupling, showed better cellular uptake and stability in blood in our previous research...
December 7, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29213225/role-of-blue-dye-for-sentinel-lymph-node-detection-in-early-endometrial-cancer
#13
Stefano Restaino, Carlo Ronsini, Angelo Finelli, Emanuele Perrone, Giovanni Scambia, Francesco Fanfani
Background: Sentinel Lymphonode analysis has become a barely new and innovative way to treat early stages of endometrial cancer (Ballester et al., Lancet Oncol 469-476, 2011; Buda et al., Ann Surg Oncol 2975-81, 2016). Indocyanine green cervical injection is considered gold standard for mapping nodes' drainage. Blue dye is used as a valid alternative in many centers, due to the lower cost of execution. The objective of this video is to prove that methylene blue dye's cervical injection is a valid and "low-cost" method to obtain mapping of lymphatic drainage in patient with early endometrial cancer...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/29213129/deep-tissue-analysis-of-distal-aqueous-drainage-structures-and-contractile-features
#14
Jose M Gonzalez, Minhee K Ko, Young-Kwon Hong, Robert Weigert, James C H Tan
Outflow resistance in the aqueous drainage tract distal to trabecular meshwork is potentially an important determinant of intraocular pressure and success of trabecular bypass glaucoma surgeries. It is unclear how distal resistance is modulated. We sought to establish: (a) multimodal 2-photon deep tissue imaging and 3-dimensional analysis of the distal aqueous drainage tract (DT) in transgenic mice in vivo and ex vivo; (b) criteria for distinguishing the DT from blood and lymphatic vessels; and (c) presence of a DT wall organization capable of contractility...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29211746/review-of-the-factors-influencing-the-motivation-of-community-drug-distributors-towards-the-control-and-elimination-of-neglected-tropical-diseases-ntds
#15
Alison Krentel, Margaret Gyapong, Shruti Mallya, Nana Yaa Boadu, Mary Amuyunzu-Nyamongo, Mariana Stephens, Deborah A McFarland
BACKGROUND: Community drug distributors or neglected tropical disease (NTD) volunteers have played a crucial role in ensuring the success of mass drug administration (MDA) programs using preventive chemotherapy (PC) for lymphatic filariasis, onchocerciasis, schistosomiasis, trachoma and soil transmitted helminths. In recent years however, a noticeable decline in motivation of some of these volunteers has been perceived, potentially negatively impacting the success of these programs. Potential hypotheses for this change in motivation include the long duration of many MDA programs, the change in sociocultural environments as well as the changes to the programs over time...
December 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29211371/-primary-lymphedema
#16
Michèle Depairon, Claudia Lessert, Didier Tomson, Lucia Mazzolai
Characterized by an aplasia, hypoplasia or dysplasia of the lymphatic network, the primary lymphedema takes part of rare diseases. If 10 % of cases are congenital, the majority of them are detected before 35 years, most of the time due to an intercurrent event suh as a sprain or an infection. Although rarer, some primaries lymphedemas are family forms such the syndromes of Milroy and Meige. The primary lymphedema can also be a part of more complex malformative diseases such as Klinefelter, Turner or Noonan syndromes...
December 6, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29211304/risk-of-recurrence-prognosis-and-follow-up-for-danish-women-with-cervical-cancer-in-2005-2013-a-national-cohort-study
#17
Gry Assam Taarnhøj, Ib Jarle Christensen, Henrik Lajer, Katrine Fuglsang, Mette Moustgaard Jeppesen, Henriette Strøm Kahr, Claus Høgdall
BACKGROUND: In developed countries, women attend follow-up after treatment for cervical cancer to detect recurrence. The aim of this study was to describe the Danish population of women with early-stage cervical cancer at risk for recurrence and death due to recurrence. METHODS: Data were extracted from 3 nationwide databases to find women diagnosed with stage 1A1 to 1B1 cervical cancer in 2005-2013. Recurrences were determined from data on oncological or surgical treatment more than 3 months after the initial diagnosis and were cross-checked with patient journals...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29211219/incidence-and-treatment-of-chylothorax-in-children-undergoing-corrective-surgery-for-congenital-heart-diseases
#18
Nicolle Martin Christofe, Cristiane Felix Ximenes Pessotti, Laércio Paiva, Ieda Biscegli Jatene
INTRODUCTION: Chylothorax is a lymphatic extravasation into pleural cavity and its incidence is 0.25%-5.3% in children undergoing cardiac surgery. OBJECTIVE: To evaluate the incidence of chylothorax in pediatrics patients operated, linking it in each surgical intervention. Evaluate treatment types and efficiency. METHODS: Retrospective study using medical records of children undergoing cardiac surgery in the Hospital do Coração between 2004 and 2014...
September 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29209988/lncrna-egot-promotes-tumorigenesis-via-hedgehog-pathway-in-gastric-cancer
#19
Wei Peng, Jianzhong Wu, Hong Fan, Jianwei Lu, Jifeng Feng
Gastric cancer (GC) is one of the mostly terminal malignancies with poor prognosis. Long noncoding RNA EGOT (EGOT) acts as a crucial regulator in the breast cancer. However, the function of EGOT in GC remains unknown. This work was to explore the clinical value and biological significance of EGOT in GC. EGOT levels in GC tissue and cell were analyzed by qRT-PCR. After knockdown of EGOT, GC cell growth and cycle progression were detected. The expression of EGOT was observably elevated in GC. Upregulation of EGOT was related with lymphatic metastasis and TNM stage...
December 5, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29209625/prediction-and-validation-of-hub-genes-associated-with-colorectal-cancer-by-integrating-ppi-network-and-gene-expression-data
#20
Yongfu Xiong, Wenxian You, Rong Wang, Linglong Peng, Zhongxue Fu
Although hundreds of colorectal cancer- (CRC-) related genes have been screened, the significant hub genes still need to be further identified. The aim of this study was to identify the hub genes based on protein-protein interaction network and uncover their clinical value. Firstly, 645 CRC patients' data from the Tumor Cancer Genome Atlas were downloaded and analyzed to screen the differential expression genes (DEGs). And then, the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis was performed, and PPI network of the DEGs was constructed by Cytoscape software...
2017: BioMed Research International
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