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https://www.readbyqxmd.com/read/29456952/clinicopathological-significance-of-tumor-lymphatic-vessel-density-in-head-and-neck-squamous-cell-carcinoma
#1
Padam Parmar, Nisha Marwah, Sanjeev Parshad, Taruna Yadav, Ashima Batra, Rajeev Sen
Various studies have demonstrated that the lymphatic system is the additional route for solid tumor metastasis. Lymph nodes metastasis in Head and neck squamous cell carcinoma (HNSCC) is a major prognostic indicator for disease progression and a guide for therapeutic strategies. We conducted a study to compare intratumoral (IT) and peritumoral (PT) lymphatic vessel density (LVD) in HNSCC using lymphatic marker D2-40 and its correlation with lymph node metastasis, histological grading and other clinicopathological parameters...
March 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29456131/high-expression-of-cc-chemokine-receptor-5-ccr5-promotes-disease-progression-in-patients-with-b-cell-non-hodgkin-lymphomas
#2
Aleksandra Butrym, Ilona Kryczek, Dorota Dlubek, Emilia Jaskula, Andrzej Lange, Artur Jurczyszyn, Grzegorz Mazur
Chemokines are small proteins, that regulate cell migration in many physiological and pathologic processes in human body. They are also responsible for cancer progression. CC chemokine receptor 5 (CCR5) is responsible for cell recruitment in inflammation and may be involved in antitumor immune response controlling. Aberrant CCR5 can be found in different kind of cancers, not only hematological, but also solid tumors. Non-Hodgkin lymphomas consist of many lymphoma subtypes. They predominantly derive from B cells and can have very heterogenous clinical course...
January 10, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29455957/the-elusive-and-ungrateful-lymphatic-circulation-may-be-a-key-determinant-of-fontan-failure
#3
EDITORIAL
Yves d'Udekem, Marc de Leval
No abstract text is available yet for this article.
February 1, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29455067/gap-enhanced-raman-tags-for-high-contrast-sentinel-lymph-node-imaging
#4
Zhouzhou Bao, Yuqing Zhang, Ziyang Tan, Xia Yin, Wen Di, Jian Ye
The sentinel lymph node (SLN) biopsy is gaining in popularity as a procedure to investigate the lymphatic metastasis of malignant tumors. The commonly used techniques to identify the SLNs in clinical practice are blue dyes-guided visualization, radioisotope-based detection and near-infrared fluorescence imaging. However, all these methods have not been found to perfectly fit the clinical criteria with issues such as short retention time in SLN, poor spatial resolution, autofluorescence, low photostability and high cost...
February 10, 2018: Biomaterials
https://www.readbyqxmd.com/read/29454741/exploiting-or-overcoming-the-dome-trap-for-enhanced-oral-immunization-and-drug-delivery
#5
REVIEW
Jianping Qi, Jie Zhuang, Yongjiu Lv, Yi Lu, Wei Wu
The microfold cells (M cells) residing in the outmost follicle-associated epithelia (FAE) of Peyer's patches capture foreign particles and hand over to sub-FAE lymphatics, where the particles are retained and disposed subsequently. A concept of "dome trap" is proposed to highlight the significance of this mechanism. For oral immunization, it is better to exploit the entrapment capacity to maximize immune response, whereas for drug delivery it is better to overcome the dome trap to transport drugs into the systemic circulation...
February 15, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29450591/occurrence-of-pneumonitis-following-radiotherapy-of-breast-cancer-a-prospective-study
#6
Danijela Vasiljevic, Christoph Arnold, David Neuman, Katharina Fink, Marina Popovscaia, Irma Kvitsaridze, Meinhard Nevinny-Stickel, Markus Glatzer, Peter Lukas, Thomas Seppi
AIM: of this study is to determine the temporal resolution of therapy-induced pneumonitis, and to assess promoting factors in adjuvant treated patients with unilateral mammacarcinoma. PATIENTS AND METHODS: A total of 100 post-surgery patients were recruited. The cohort was treated by 2 field radiotherapy (2FRT; breast and chest wall, N = 75), 3 field radiotherapy (3FRT; + supraclavicular lymphatic region, N = 8), or with 4 field radiotherapy (4FRT; + parasternal lymphatic region, N = 17)...
February 15, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29448312/prognostic-significance-of-poorly-differentiated-clusters-and-tumor-budding-in-colorectal-liver-metastases
#7
Gilton M Fonseca, Evandro S de Mello, Sheila F Faraj, Jaime A P Kruger, Fabricio F Coelho, Vagner B Jeismann, Renato M Lupinacci, Ivan Cecconello, Venancio A F Alves, Timothy M Pawlik, Paulo Herman
BACKGROUND: Histomorphological features have been described as prognostic factors after resection of colorectal liver metastases (CLM). The objectives of this study were to assess the prognostic significance of tumor budding (TB) and poorly differentiated clusters (PDC) among CLM, and their association with other prognostic factors. METHODS: We evaluated 229 patients who underwent a first resection of CLM. Slides stained by HE were assessed for TB, PDC, tumor border pattern, peritumoral pseudocapsule, peritumoral, and intratumoral inflammatory infiltrate...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29448250/overexpression-of-lymphocyte-antigen-6-complex-locus-e-in-gastric-cancer-promotes-cancer-cell-growth-and-metastasis
#8
Yan Lv, Yu Song, Chen Ni, Shaokai Wang, Zhipeng Chen, Xiaojing Shi, Qin Jiang, Cong Cao, Yun Zuo
BACKGROUND/AIMS: Lymphocyte antigen 6 complex, locus E (LY6E) is a member of the lymphostromal cell membrane Ly6 superfamily protein. The present study investigated the clinical significance and potential biological function of LY6E in gastric cancer (GC). METHODS: LY6E mRNA and protein expressions in human GC tissues and GC cells were tested. Relationship between LY6E expression and the GC patients' clinicopathologic characteristics was analyzed. LY6E was silenced by siRNA in the cultured GC cells...
February 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29447908/primary-lymphedema-and-other-lymphatic-anomalies-are-associated-with-22q11-2-deletion-syndrome
#9
Marta Unolt, Jessica Barry, Maria Cristina Digilio, Bruno Marino, Anne Bassett, Erwin Oechslin, David W Low, Jean B Belasco, Staci Kallish, Kathleen Sullivan, Elaine H Zackai, Donna M McDonald-McGinn
BACKGROUND: Lymphedema is an abnormal accumulation of interstitial fluid within the tissues. Primary lymphedema is caused by aberrant lymphangiogenesis and it has been historically classified based on age at presentation. Although most cases are sporadic, primary lymphedema may be familial or present in association with chromosomal abnormalities and syndromic disorders. To the best of our knowledge, primary lymphedema has never been described in patients with 22q11.2 deletion syndrome...
February 12, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29447887/thirty-day-perioperative-outcomes-in-resection-of-cervical-lymphatic-malformations
#10
Ashoke Khanwalkar, John Carter, Bharat Bhushan, Jeff Rastatter, John Maddalozzo
INTRODUCTION: Limited information exists regarding short-term morbidity in the resection of lymphatic malformations. In order to make informed collaborative medical decisions, clinicians and families would benefit from information on 30-day outcomes and the expected course associated with surgical excision of lymphatic malformations. METHODS: A retrospective chart review was conducted to develop a case series of patients who underwent resection of lymphatic malformation at a pediatric tertiary care center between June 1, 2007 and September 30, 2016...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29446767/clapo-syndrome-identification-of-somatic-activating-pik3ca-mutations-and-delineation-of-the-natural-history-and-phenotype
#11
Lara Rodriguez-Laguna, Kristina Ibañez, Gema Gordo, Sixto Garcia-Minaur, Fernando Santos-Simarro, Noelia Agra, Elena Vallespín, Victoria E Fernández-Montaño, Rubén Martín-Arenas, Ángela Del Pozo, Héctor González-Pecellín, Rocío Mena, Inmaculada Rueda-Arenas, María V Gomez, Cristina Villaverde, Ana Bustamante, Carmen Ayuso, Víctor L Ruiz-Perez, Julián Nevado, Pablo Lapunzina, Juan C Lopez-Gutierrez, Victor Martinez-Glez
PurposeCLAPO syndrome is a rare vascular disorder characterized by capillary malformation of the lower lip, lymphatic malformation predominant on the face and neck, asymmetry, and partial/generalized overgrowth. Here we tested the hypothesis that, although the genetic cause is not known, the tissue distribution of the clinical manifestations in CLAPO seems to follow a pattern of somatic mosaicism.MethodsWe clinically evaluated a cohort of 13 patients with CLAPO and screened 20 DNA blood/tissue samples from 9 patients using high-throughput, deep sequencing...
February 15, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29446253/elevated-trim44-promotes-intrahepatic-cholangiocarcinoma-progression-by-inducing-cell-emt-via-mapk-signaling
#12
Rui Peng, Peng-Fei Zhang, Chi Zhang, Xiao-Yong Huang, Yan-Bing Ding, Bin Deng, Dou-Sheng Bai, Ya-Ping Xu
Surgical results for intrahepatic cholangiocarcinoma (ICC) remain unsatisfactory due to the high rate of recurrence. Here, we investigated that the expression and roles of tripartite motif-containing protein 44 (TRIM44) in human ICCs. Firstly, TRIM44 expression was analyzed in several kinds of cancers by referring to public Oncomine database, and the expressions of TRIM44 mRNA and protein were tested in ICC and corresponding paratumorous tissues. Secondly, functions and mechanisms of TRIM44 in ICC cells were further evaluated by TRIM44 interference and cDNA transfection...
February 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29445855/-treatment-strategy-for-early-stage-rectal-cancer-t1-carcinoma
#13
REVIEW
G Liebig-Hörl, C Puchner, M Gerken, M Klinkhammer-Schalke, A Fürst
BACKROUND: A common consensus for the definition for early rectal cancer does not exist. This item is used in cases of histological findings including pTis, pT1 or pT2 tumors. The term early rectal cancer is not mentioned in the German S3 guidelines on colorectal cancer. The pTis tumors are located at the mucosa level of the intestinal wall and they have nearly no tendency to develop metastases but pT2 tumors have a high risk of local metastases; therefore, the term early rectal cancer is not adequate for pT2 tumors...
February 14, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29445289/expression-of-nemo-like-kinase-in-cervical-squamous-cell-carcinoma-a-clinicopathological-study
#14
Weina Yang, Lina Gu, Chang Yang, Tianbo Liu
Objective: Nemo-like kinase (NLK) has been reported to play different roles in tumors. However, the role of NLK in cervical squamous cell carcinoma (CSCC) remains unknown. In this study, we explored the clinical significance including survival of NLK protein expression in CSCCs. Patients and methods: Immunohistochemical method was performed using tissues from 130 patients with CSCC. The associations between NLK expression and the clinicopathological factors and prognosis of CSCCs were evaluated...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29444743/tumor-suppressive-microrna-708-targets-notch1-to-suppress-cell-proliferation-and-invasion-in-gastric-cancer
#15
Xuyan Li, Xuanfang Zhong, Xiuhua Pan, Yan Ji
Growing evidence demonstrated that numerous microRNAs (miRNAs) may participate in the regulation of gastric carcinogenesis and progression. This phenomenon suggests that gastric cancer-related miRNAs can be identified as effective therapeutic targets for this disease. MiRNA-708 (miR-708) has recently been reported to be aberrantly expressed in several types of cancer and contribute to carcinogenesis and progression. However, the expression level, biological roles and underlying mechanisms of miR-708 in gastric cancer are poorly understood...
February 14, 2018: Oncology Research
https://www.readbyqxmd.com/read/29444715/porcine-wharton-s-jelly-cells-distribute-throughout-the-body-after-intraperitoneal-injection
#16
Kreeson Packthongsuk, Theresa Rathbun, Deryl Troyer, Duane L Davis
BACKGROUND: Wharton's jelly cells (WJCs) have multiple differentiation potentials and are easily harvested in large numbers. WJCs are well tolerated in allogeneic environments and there is a growing list of their therapeutic effects. Most therapies require administering large numbers of cells and this is generally accomplished by intravenous injection. Here, we studied the locations of porcine WJCs in immune-competent, allogeneic hosts after intraperitoneal (IP) injection. METHODS: Male porcine WJCs were administered to female neonatal piglets by IP injection...
February 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29444078/multiplex-serology-for-impact-evaluation-of-bed-net-distribution-on-burden-of-lymphatic-filariasis-and-four-species-of-human-malaria-in-northern-mozambique
#17
Mateusz M Plucinski, Baltazar Candrinho, Geraldo Chambe, João Muchanga, Olinda Muguande, Graça Matsinhe, Guidion Mathe, Eric Rogier, Timothy Doyle, Rose Zulliger, James Colborn, Abu Saifodine, Patrick Lammie, Jeffrey W Priest
BACKGROUND: Universal coverage with long-lasting insecticidal nets (LLINs) is a primary control strategy against Plasmodium falciparum malaria. However, its impact on the three other main species of human malaria and lymphatic filariasis (LF), which share the same vectors in many co-endemic areas, is not as well characterized. The recent development of multiplex antibody detection provides the opportunity for simultaneous evaluation of the impact of control measures on the burden of multiple diseases...
February 14, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29442477/role-of-thyroid-ultrasound-combined-with-thyroglobulin-in-the-diagnosis-of-postoperative-recurrence-of-thyroid-cancer
#18
Li Zhang, Guilan Zou
BACKGROUND: To study the application value of thyroid ultrasound combined with thyroglobulin (Tg) in the diagnosis of postoperative recurrence of thyroid cancer, so as to provide a reference for clinical practice. METHODS: 80 patients with thyroid cancer who underwent operative treatment for more than 2 times in our hospital from January 2014 to December 2016 were selected as the objects of study. After operation, residual thyroid tissues were removed via131 iodine (131 I)treatment, the serum Tg and thyroid globulin antibody (TgAb) were detected, and the cervical ultrasound was performed...
February 13, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29440731/microarray-profile-of-circular-rnas-identifies-hsa_circ_0014130-as-a-new-circular-rna-biomarker-in-non-small-cell-lung-cancer
#19
Shaoyan Zhang, Xiaoli Zeng, Ting Ding, Lin Guo, Yulong Li, Songlei Ou, Hui Yuan
Accumulating evidence has revealed that aberrant Circular RNAs (circRNAs) expression plays important roles in carcinogenesis and tumor progression. However, their role in non-small cell lung cancer (NSCLC) remains unclear. In this study, we first used circRNA microarrays to screen for tumour-specific circRNA candidates in between NSCLC (n = 3) and adjacent lung (n = 3) tissue. Among the circRNA expression profile, two circRNAs (hsa_circ_0014130 and hsa_circ_0016760) were selected for validation in ten pairs of NSCLC and adjacent non-cancerous tissues by real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR)...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440349/genetic-tests-in-lymphatic-vascular-malformations-and-lymphedema
#20
Sandro Michelini, Stefano Paolacci, Elena Manara, Costantino Eretta, Raul Mattassi, Byung-Boong Lee, Matteo Bertelli
Syndromes with lymphatic malformations show phenotypic variability within the same entity, clinical features that overlap between different conditions and allelic as well as locus heterogeneity. The aim of this review is to provide a comprehensive clinical genetic description of lymphatic malformations and the techniques used for their diagnosis, and to propose a flowchart for genetic testing. Literature and database searches were performed to find conditions characterised by lymphatic malformations or the predisposition to lymphedema after surgery, to identify the associated genes and to find the guidelines and genetic tests currently used for the molecular diagnosis of these disorders...
February 9, 2018: Journal of Medical Genetics
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