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https://www.readbyqxmd.com/read/28214888/analysis-of-long-non-coding-rna-expression-of-lymphatic-endothelial-cells-in-response-to-type-2-diabetes
#1
Min Qi, Qiuhong Zhou, Weiqi Zeng, Minxue Shen, Xiaomin Liu, Chang Luo, Jing Long, Wangqing Chen, Jianglin Zhang, Siyu Yan
BACKGROUND: Recent evidence has indicated that long non-coding RNA (lncRNA) is involved in the pathogenesis of type 2 diabetes, but nothing is known about lncRNA expression changes of lymphatic endothelial cells in response to type 2 diabetes. METHODS: The GSE38396 dataset was downloaded from the Gene Expression Omnibus database and the probe sets of Human Gnome U133 Plus2.0 microarray were annotated for lncRNA. Differentially expressed lncRNAs between diabetic and non-diabetic lymphatic endothelial cells were calculated...
January 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214496/new-diagnostic-modalities-in-the-evaluation-of-lymphedema
#2
REVIEW
Thomas F O'Donnell, John C Rasmussen, Eva M Sevick-Muraca
OBJECTIVE: Currently, lymphedema (LED) is typically diagnosed clinically on the basis of a patient's history and characteristic physical findings. Whereas the diagnosis of LED is sometimes confirmed by lymphoscintigraphy (LSG), the technique is limited in both its ability to identify disease and to guide therapy. Recent advancements provide opportunities for new imaging techniques not only to assist in the diagnosis of LED, based on anatomic changes, but also to assess contractile function and to guide therapeutic intervention...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28214320/indocyanine-green-assisted-sentinel-lymph-node-biopsy-in-melanoma-using-the-fovis-system
#3
Daniela Göppner, Stephan Nekwasil, Anne Jellestad, Alexander Sachse, Karl-Heinz Schönborn, Harald Gollnick
BACKGROUND: Metastatic involvement of the sentinel lymph node (SLN) represents a key prognostic factor in melanoma. The combined use of a radiocolloid (technetium-99m) and blue dye is the gold standard in sentinel lymph node biopsy (SLNB). In this context, near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) has been suggested as an alternative. The objective of the present study was to examine the potential advantages of fluorescence-guided SLNB - compared to the conventional method - with respect to the visualization of lymphatic drainage pathways and the SLN...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28214211/expression-of-bmp-4-in-papillary-thyroid-carcinoma-and-its-correlation-with-tumor-invasion-and-progression
#4
Xiaomei Meng, Peng Zhu, Ning Li, Jinchen Hu, Shaoguang Wang, Shuguang Pang, Jiahui Wang
Bone morphogenetic protein 4 (BMP-4) is a member of the BMP protein family. BMP-4 was reported to induce epithelial-mesenchymal transition (EMT) and promote tumor cell immigration and invasion. This study aimed to investigate the expression of BMP-4 in papillary thyroid carcinoma (PTC) and its correlation with the patients' clinicophathological features and with tumor invasion and metastasis. Surgically resected PTC specimens from 82 patients admitted to the Department of Thyroid Surgery of Yantai Yuhuangding Hospital between Feb 1st and May 31st, 2016 were collected...
January 17, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28213790/optical-see-through-cancer-vision-goggles-enable-direct-patient-visualization-and-real-time-fluorescence-guided-oncologic-surgery
#5
Suman B Mondal, Shengkui Gao, Nan Zhu, LeMoyne Habimana-Griffin, Walter J Akers, Rongguang Liang, Viktor Gruev, Julie Margenthaler, Samuel Achilefu
BACKGROUND: The inability to visualize the patient and surgical site directly, limits the use of current near infrared fluorescence-guided surgery systems for real-time sentinel lymph node biopsy and tumor margin assessment. METHODS: We evaluated an optical see-through goggle augmented imaging and navigation system (GAINS) for near-infrared, fluorescence-guided surgery. Tumor-bearing mice injected with a near infrared cancer-targeting agent underwent fluorescence-guided, tumor resection...
February 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28213627/real-time-mri-guided-percutaneous-sclerotherapy-of-low-flow-head-and-neck-lymphatic-malformations-in-the-pediatric-population-a-stepwise-approach
#6
Sasan Partovi, Lorenna Vidal, Ziang Lu, Dean A Nakamoto, Ji Buethe, Mark Clampitt, Michael Coffey, Indravadan J Patel
Real-time MRI-guided percutaneous sclerotherapy is a novel and evolving treatment for congenital lymphatic malformations in the head and neck. We elaborate on the specific steps necessary to perform an MRI-guided percutaneous sclerotherapy of lymphatic malformations including pre-procedure patient work-up and preparation, stepwise intraprocedural interventional techniques and post-procedure management. Based on our institutional experience, MRI-guided sclerotherapy with a doxycycline-gadolinium-based mixture as a sclerosant for lymphatic malformations of the head and neck region in children is well tolerated and effective...
February 17, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28213094/aspirin-triggered-resolvin-d1-modified-materials-promote-the-accumulation-of-pro-regenerative-immune-cell-subsets-and-enhance-vascular-remodeling
#7
Mary Caitlin P Sok, Maxianne C Tria, Claire E Olingy, Cheryl L San Emeterio, Edward A Botchwey
: Many goals in tissue engineering rely on modulating cellular localization and polarization of cell signaling, including the inhibition of inflammatory infiltrate, facilitation of inflammatory cell egress, and clearance of apoptotic cells. Omega-3 polyunsaturated fatty acid-derived resolvins are gaining increasing recognition for their essential roles in inhibition of neutrophil invasion into inflamed tissue and promotion of macrophage phagocytosis of cellular debris as well as their egress to the lymphatics...
February 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28212666/classical-hodgkin-lymphoma-masquerading-as-chronic-recurrent-multifocal-osteomyelitis-a-case-report
#8
Michael Pham, Steven Ressler, Allison Rosenthal, Katalin Kelemen
BACKGROUND: Hodgkin lymphoma is a hematologic malignancy usually confined to lymphatic structures and commonly associated with constitutional symptoms. Bony involvement and musculoskeletal symptoms are uncommon and typically seen in advanced disease. In this case, we report an unusual presentation of classical Hodgkin lymphoma and highlight diagnostic challenges leading to the misdiagnosis and treatment as chronic recurrent multifocal osteomyelitis. CASE PRESENTATION: A 38-year-old white man presented with lower extremity musculoskeletal pain...
February 18, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28211296/recommendations-for-the-medical-management-of-chronic-venous-disease-the-role-of-micronized-purified-flavanoid-fraction-mpff
#9
Ronald Bush, Anthony Comerota, Mark Meissner, Joseph D Raffetto, Steven R Hahn, Katherine Freeman
Scope A systematic review of the clinical literature concerning medical management of chronic venous disease with the venoactive therapy Micronized Purified Flavonoid Fraction was conducted in addition to an investigation of the hemodynamics and mechanism of chronic venous disease. Methods The systematic review of the literature focused on the use of Micronized Purified Flavonoid Fraction (diosmin) which has recently become available in the US, in the management of chronic venous disease. The primary goal was to assess the level of evidence of the role of Micronized Purified Flavonoid Fraction in the healing of ulcers, and secondarily on the improvement of the symptoms of chronic venous disease such as edema...
April 2017: Phlebology
https://www.readbyqxmd.com/read/28211204/evaluation-of-the-enhanced-permeability-and-retention-effect-in-the-early-stages-of-lymph-node-metastasis
#10
Mamoru Mikada, Ariunbuyan Sukhbaatar, Yoshinobu Miura, Sachiko Horie, Maya Sakamoto, Shiro Mori, Tetsuya Kodama
Most solid cancers spread to new sites via the lymphatics before hematogenous dissemination. However, only a small fraction of an intravenously administered anti-cancer drug enters the lymphatic system to reach metastatic lymph nodes (LNs). Here, we show that the enhanced permeability and retention (EPR) effect is not induced during the early stages of LN metastasis. Luciferase-expressing tumor cells were injected into the subiliac LN of the MXH10/Mo-lpr/lpr mouse to induce metastasis to the proper axillary LN (PALN)...
February 17, 2017: Cancer Science
https://www.readbyqxmd.com/read/28210768/the-lymphatic-circulation-in-adaptations-to-the-fontan-circulation
#11
REVIEW
Sabarinath Menon, Murthy Chennapragada, Shinya Ugaki, Gary F Sholler, Julian Ayer, David S Winlaw
Failing Fontan continues to be major problem for patients on the univentricular pathway. Failing Fontan is often complicated by chylothorax, plastic bronchitis and protein loosing enteropathy. The role of lymphatic circulation in Fontan circulation is still being researched. Newer imaging modalities give insight into the role of abnormal dilatation and retrograde flow in lymphatic channels post Fontan. Interventional strategies targeting abnormal lymphatic channels, provides an alternative management strategy for patients with failing Fontan...
February 16, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28209511/heparanase-1-induced-shedding-of-heparan-sulfate-from-syndecan-1-in-hepatocarcinoma-cell-facilitates-lymphatic-endothelial-cell-proliferation-via-vegf-c-erk-pathway
#12
Shengjin Yu, Huiming Lv, He Zhang, Yu Jiang, Yu Hong, Rongjun Xia, Qifang Zhang, Weiwei Ju, Lili Jiang, Geng Ou, Jinhui Zhang, Shujing Wang, Jianing Zhang
Heparanase-1/syndecan-1 axis plays critical roles in tumorigenesis and development. The main mechanism includes heparanase-1 (HPA-1) degrades the heparan sulfate chain of syndecan-1 (SDC-1), and the following shedding of heparan sulfate from tumor cell releases and activates SDC-1 sequestered growth factors. However, the significance of Heparanase-1/syndecan-1 axis and its effects on the microenvironment of lymphatic metastasis in hepatocellular carcinogenesis (HCC) procession have not been reported. Herein, we found that HPA-1 could degrade the heparan sulfate on hepatocarcinoma cell surface...
February 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28208928/pulsatile-clavicular-swelling-as-the-sole-presentation-of-asymptomatic-renal-cell-carcinoma-with-an-isolated-metastasis-to-the-clavicle-a-case-report
#13
Ashwani Kumar, Nitish Arora, Paras Kumar Pandove, Garima Anand, Bharti Arora
Renal Cell Carcinoma (RCC) is notorious for its unpredictable dissemination patterns involving both lymphatic and haematogenous route without a clear-cut preponderance for any. Unlike other intra-abdominal malignancies like colorectal carcinoma, renal cell carcinoma is often known to metastasize to distant sites even after a confident and unsuspecting curative resection or often as the primary presentation constantly adding and agitating our presentation patterns for this sneaky tumour. Presented below is a case of such an unsuspecting female patient...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207940/structural-and-functional-changes-to-lymph-nodes-in-ageing-mice
#14
Vivian M Turner, Neil A Mabbott
Lymph nodes (LN) are secondary lymphoid organs spread throughout the lymphatic system. They function to filter pathogenic material from the lymphatic fluid to maintain the health of the organism. Subcapsular sinus macrophages (SCSM) are amongst the first-responders within the LN due to their strategic location within the subcapsular sinus region. These macrophages aid the delivery of immune complexes to B cells and follicular dendritic cells (FDC) within the LN. Here we show an increase in SCSM and other macrophage populations within aged LN...
February 16, 2017: Immunology
https://www.readbyqxmd.com/read/28207792/partnering-for-impact-integrated-transmission-assessment-surveys-for-lymphatic-filariasis-soil-transmitted-helminths-and-malaria-in-haiti
#15
Alaine Kathryn Knipes, Jean Frantz Lemoine, Franck Monestime, Carl R Fayette, Abdel N Direny, Luccene Desir, Valery E Beau de Rochars, Thomas G Streit, Kristen Renneker, Brian K Chu, Michelle A Chang, Kimberly E Mace, Kimberly Y Won, Patrick J Lammie
BACKGROUND: Since 2001, Haiti's National Program for the Elimination of Lymphatic Filariasis (NPELF) has worked to reduce the transmission of LF through annual mass drug administration with diethylcarbamazine and albendazole. The NPELF reached full national coverage with MDA for LF in 2012, and by 2014, a total of 14 evaluation units (48 communes) had met WHO eligibility criteria to conduct LF transmission assessment surveys (TAS) to determine whether prevalence had been reduced to below a threshold, such that transmission is assumed to be no longer sustainable...
February 16, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28205389/growth-inhibition-of-formed-corneal-neovascularization-following-fosaprepitant-treatment
#16
Fabio Bignami, Anna Lorusso, Paolo Rama, Giulio Ferrari
PURPOSE: The aim of this study was to test the efficacy of Neurokinin-1 Receptor (NK-1R) antagonist -Fosaprepitant- in inducing regression of established corneal neovascularization (CNV). METHODS: Twenty C57BL/6 mice underwent alkali burn. Seven days later, when corneal neovessels had developed, they received Fosaprepitant 10 mg/ml, administered topically six times a day in the right eye for 10 days. In parallel, a group of 20 causticated mice was treated with normal saline, as control...
February 15, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28203421/clinical-significance-of-preoperative-carcinoembryonic-antigen-level-in-patients-with-clinical-stage-ia-non-small-cell-lung-cancer
#17
Ryo Maeda, Takashi Suda, Ayumi Hachimaru, Daisuke Tochii, Sachiko Tochii, Yasushi Takagi
BACKGROUND: The objective of this study was to assess the preoperative serum carcinoembryonic antigen (CEA) level in patients with clinical stage IA non-small cell lung cancer (NSCLC) and to evaluate its clinical significance. METHODS: Between January 2005 and December 2014, a total of 378 patients with clinical stage IA NSCLC underwent complete resection with systematic node dissection. The survival rate was estimated starting from the date of surgery to the date of either death or the last follow-up by the Kaplan-Meier method...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28203117/peritumoral-lymphatic-vessel-density-and-invasion-detected-with-immunohistochemical-marker-d240-is-strongly-associated-with-distant-metastasis-in-breast-carcinoma
#18
Nur Fatiha Norhisham, Choi Yen Chong, Sabreena Safuan
BACKGROUND: Detection of vascular invasion by hematoxylin and eosin staining is the current pathological assessment practice to diagnose breast carcinoma. However, conventional hematoxylin and eosin staining failed to distinguish between blood vessel invasion and lymphatic vessel invasion. Both are important prognostic criteria however with different outcomes. The aim of this study is to distinguish between blood vessel invasion and lymphatic vessel invasion using conventional assessment and immunohistochemical markers...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/28202188/rate-of-regional-nodal-metastases-of-cutaneous-squamous-cell-carcinoma-in-the-immunosuppressed-patient
#19
Eamon J McLaughlin, Lauren Miller, Thuzar M Shin, Joseph F Sobanko, Steven B Cannady, Christopher J Miller, Jason G Newman
PURPOSE: Immunosuppressed solid organ transplant recipients (SOTRs) have an increased risk of developing cutaneous squamous cell carcinomas (cSCCs) with metastatic potential. This study sought to determine the rate of regional lymph node involvement in a large cohort of solid organ transplant patients with cutaneous head and neck squamous cell carcinoma. MATERIALS AND METHODS: A retrospective chart review was performed on solid organ transplant patients with head and neck cutaneous squamous cell carcinoma treated at a tertiary academic medical center from 2005 to 2015...
February 4, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28199317/colorimetric-tests-for-diagnosis-of-filarial-infection-and-vector-surveillance-using-non-instrumented-nucleic-acid-loop-mediated-isothermal-amplification-nina-lamp
#20
Catherine B Poole, Zhiru Li, Andy Alhassan, Dylan Guelig, Steven Diesburg, Nathan A Tanner, Yinhua Zhang, Thomas C Evans, Paul LaBarre, Samuel Wanji, Robert A Burton, Clotilde K S Carlow
Accurate detection of filarial parasites in humans is essential for the implementation and evaluation of mass drug administration programs to control onchocerciasis and lymphatic filariasis. Determining the infection levels in vector populations is also important for assessing transmission, deciding when drug treatments may be terminated and for monitoring recrudescence. Immunological methods to detect infection in humans are available, however, cross-reactivity issues have been reported. Nucleic acid-based molecular assays offer high levels of specificity and sensitivity, and can be used to detect infection in both humans and vectors...
2017: PloS One
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