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https://www.readbyqxmd.com/read/29783244/some-features-of-the-behavior-of-alcohol-dependent-persons
#1
Ihor М Karpinets, Oksana V Marusyn
OBJECTIVE: Introduction: Alcoholism is characterized by psychological dependence and changes in human behavior, which affects the person's relationship with the social environment. The aim: to determine the behavior of alcohol dependent persons basing on the retrospective study. PATIENTS AND METHODS: Materials and methods: On the basis of narcological offices of healthcare establishments and narcological clinic in Ivano-Frankivsk oblast, 552 people being in follow-up by a narcologist as addicted or abused have been examined for a specially developed extended program based on a standardized AUDIT screening test...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782552/role-of-kinesins-in-directed-adenovirus-transport-and-cytoplasmic-exploration
#2
Jie Zhou, Julian Scherer, Julie Yi, Richard B Vallee
Many viruses, including adenovirus, exhibit bidirectional transport along microtubules following cell entry. Cytoplasmic dynein is responsible for microtubule minus end transport of adenovirus capsids after endosomal escape. However, the identity and roles of the opposing plus end-directed motor(s) remain unknown. We performed an RNAi screen of 38 kinesins, which implicated Kif5B (kinesin-1 family) and additional minor kinesins in adenovirus 5 (Ad5) capsid translocation. Kif5B RNAi markedly increased centrosome accumulation of incoming Ad5 capsids in human A549 pulmonary epithelial cells within the first 30 min post infection, an effect dramatically enhanced by blocking Ad5 nuclear pore targeting using leptomycin B...
May 21, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29779720/search-engines-news-wires-and-digital-epidemiology-presumptions-and-facts
#3
Fatemeh Kaveh-Yazdy, Ali-Mohammad Zareh-Bidoki
BACKGROUND: Digital epidemiology tries to identify diseases dynamics and spread behaviors using digital traces collected via search engines logs and social media posts. However, the impacts of news on information-seeking behaviors have been remained unknown. METHODS: Data employed in this research provided from two sources, (1) Parsijoo search engine query logs of 48 months, and (2) a set of documents of 28 months of Parsijoo's news service. Two classes of topics, i...
July 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29779553/social-work-student-and-practitioner-roles-in-integrated-care-settings
#4
Erin P Fraher, Erica Lynn Richman, Lisa de Saxe Zerden, Brianna Lombardi
INTRODUCTION: Social workers are increasingly being deployed in integrated medical and behavioral healthcare settings but information about the roles they fill in these settings is not well understood. This study sought to identify the functions that social workers perform in integrated settings and identify where they acquired the necessary skills to perform them. METHODS: Master of social work students (n=21) and their field supervisors (n=21) who were part of a Health Resources and Services Administration-funded program to train and expand the behavioral health workforce in integrated settings were asked how often they engaged in 28 functions, where they learned to perform those functions, and the degree to which their roles overlapped with others on the healthcare team...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29779513/common-sexually-transmitted-infections-in-women
#5
REVIEW
Ashley L Hodges, Aimee Chism Holland
The spread of sexually transmitted infections (STIs) remains a significant public health issue in the United States. Social, economic, and behavioral implications affecting the spread of STIs have been identified. The most important social factor in the United States is the stigma associated with discussing sex and STI screening. In this article, specific recommendations for women are included regarding screening, diagnosing, and treating common vaginal and cervical infections. Screening women for infections of the vagina and cervix is essential because untreated infections may result in complications that have current and long-term health consequences and impact quality of life...
June 2018: Nursing Clinics of North America
https://www.readbyqxmd.com/read/29779198/redeveloping-substance-abuse-treatment-for-military-personnel
#6
REVIEW
Christian Schrader, Antoinette Lenton, Peter Gertonson, Alexander Rahimi
PURPOSE OF REVIEW: We review the prevailing evidence surrounding treatment of substance use disorder (SUD), with specific focus on alcohol, tobacco, and prescription opiates, and how it informs guidelines for treating active duty military. We survey the evidence regarding preventive screening, treatment, and relapse prevention in substance misuse as it pertains to patient-centered care of the service member. RECENT FINDINGS: Holistic, patient-centered care with an emphasis on identifying maladaptive use or dependence prior to progression to chronic disease is now recognized as the evidenced approach to treating substance use disorders...
May 19, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29779146/food-addiction-orthorexia-and-food-related-stress-among-dietetics-students
#7
Maria G Grammatikopoulou, Konstantinos Gkiouras, Anastasia Markaki, Xenophon Theodoridis, Vasiliki Tsakiri, Pantelis Mavridis, Theodore Dardavessis, Michael Chourdakis
PURPOSE: Health sciences, and in particular Nutrition and Dietetics students, have been shown to exhibit an increased prevalence of disordered eating. The aim of the present cross-sectional study was to evaluate other specified feeding and eating disorders (OSFEDs), including stress-related eating, food addiction, and orthorexia, in relation to the dietary intake, among nutrition/dietetics students. METHODS: A total of 176 undergraduate students from a Department of Nutrition and Dietetics, in Greece, participated in the study...
May 19, 2018: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29777781/screen-related-parenting-practices-in-low-income-mexican-american-families
#8
Darcy A Thompson, Sarah J Schmiege, Susan L Johnson, Elizabeth A Vandewater, Richard E Boles, Ruth E Zambrana, Jerusha Lev, Jeanne M Tschann
OBJECTIVES: To (1) examine whether the Information, Motivation, and Behavioral Skills Model predicts maternal screen-related parenting practices and (2) evaluate the relationship of American Academy of Pediatrics(AAP)-recommended parenting practices with child television (TV) use behaviors. METHODS: In this cross-sectional study, 312 Spanish- and/or English-speaking female primary caregivers of Mexican descent with a child 3-5 years of age were recruited from safety-net pediatric clinics...
May 16, 2018: Academic Pediatrics
https://www.readbyqxmd.com/read/29776623/nonrestorative-sleep-in-healthy-young-adults-without-insomnia-associations-with-executive-functioning-fatigue-and-pre-sleep-arousal
#9
Ruben Tinajero, Paula G Williams, Matthew R Cribbet, Holly K Rau, Daniel L Bride, Yana Suchy
OBJECTIVES: Previous research suggests that nonrestorative sleep (NRS), even in the absence of insomnia symptoms or other sleep disorders, may be associated with daytime dysfunction. This study examined the association between NRS and daytime dysfunction in healthy adults screened for insomnia and sleep apnea. DESIGN: Multi-day assessment approach. SETTING: Community-based adults and college students. PARTICIPANTS: Healthy young adults without insomnia and sleep apnea (n = 79; 68% female, mean age = 27...
June 2018: Sleep Health
https://www.readbyqxmd.com/read/29776474/correlates-of-physical-activity-and-sedentary-behaviors-among-overweight-hispanic-school-aged-children
#10
Kimberly R Hartson, Bonnie Gance-Cleveland, Claudia R Amura, Sarah Schmiege
PURPOSE: The purpose of this study was to explore potential correlates of physical activity and sedentary screen time behaviors among overweight Hispanic school-aged children, ages 7 to 14years. DESIGN AND METHODS: We conducted an exploratory correlation analysis using baseline data of 40 child-parent dyads from the "Mind Exercise Nutrition Do It!" program conducted in the Western United States. RESULTS: Child self-esteem and parental vegetable intake were moderately associated with physical activity, while parental vegetable intake and child fruit intake were strongly associated with physical activity among males...
May 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29776145/applicability-of-kerker-preconditioning-scheme-to-the-self-consistent-density-functional-theory-calculations-of-inhomogeneous-systems
#11
Yuzhi Zhou, Han Wang, Yu Liu, Xingyu Gao, Haifeng Song
The Kerker preconditioner, based on the dielectric function of homogeneous electron gas, is designed to accelerate the self-consistent field (SCF) iteration in the density functional theory calculations. However, a question still remains regarding its applicability to the inhomogeneous systems. We develop a modified Kerker preconditioning scheme which captures the long-range screening behavior of inhomogeneous systems and thus improves the SCF convergence. The effectiveness and efficiency is shown by the tests on long-z slabs of metals, insulators, and metal-insulator contacts...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29774782/the-neuroprotective-effect-of-ethanol-intoxication-in-tbi-is-associated-with-the-suppression-of-erbb-signaling-in-pv-positive-interneurons
#12
Akila Chandrasekar, Florian Olde Heuvel, Martin Wepler, Rida Rehman, Annette Palmer, Alberto Catanese, Birgit Linkus, Albert Ludolph, Tobias Boeckers, Markus Huber-Lang, Peter Radermacher, Francesco Roselli
Ethanol intoxication (EI) is a frequent comorbidity of TBI, but the impact of EI on TBI pathogenic cascades and prognosis is unclear: although clinical evidence suggests that EI may have neuroprotective effects, experimental support is, to date, inconclusive. We aimed at elucidating the impact of EI on TBI-associated neurological deficits, signaling pathways and pathogenic cascades, in order to identify new modifiers of TBI pathophysiology. We have shown that ethanol administration (5g/Kg) before trauma enhances behavioral recovery in a weight-drop TBI model; neuronal survival in the injured somatosensory cortex was enhanced by EI...
May 18, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29773818/predicting-transmission-blocking-potential-of-anti-malarial-compounds-in-the-mosquito-feeding-assay-using-plasmodium-falciparum-male-gamete-inhibition-assay
#13
Gonzalo Colmenarejo, Sonia Lozano, Carolina González-Cortés, David Calvo, Juliana Sanchez-Garcia, Jesús-Luís Presa Matilla, Didier Leroy, Janneth Rodrigues
Plasmodium falciparum Standard Membrane Feeding Assay (PfSMFA) is the current gold standard mosquito based confirmatory transmission blocking (TrB) assay for human malaria. However, owing to its complexity only selected gametocytocidal molecules are progressed into SMFA. Predictive tools for evaluation of TrB behavior of compounds in SMFA would be extremely beneficial, but lack of substantially large data sets from many mosquito feeds preempts the ability to perform correlations between outcomes from in vitro assays and SMFA...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773357/acute-transverse-myelitis-following-an-opsoclonus-myoclonus-syndrome-an-unusual-presentation
#14
Thomas Simon, Emmanuel Cheuret, Léa Fiedler, Catherine Mengelle, Eloïse Baudou, Kumaran Deiva
Opso-myoclonus syndrome (OMS) is a very rare and severe condition. Ataxia, opsoclonus, myoclonus and/or behavioral and sleeping disturbances define that autoimmune disorder syndrome which is paraneoplastic or triggered by an infection. Here, we report a 3 year-old immunocompetent boy who developed an atypical OMS which was later complicated by an acute transverse myelitis. Screening for neuroblastoma was negative and extensive infectious screening revealed an active HHV-6 infection confirmed by blood and cerebrospinal fluid PCR...
May 8, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29772278/zika-virus-incidence-preventive-and-reproductive-behaviors-correlates-from-new-survey-data
#15
Climent Quintana-Domeque, José Raimundo Carvalho, Victor Hugo de Oliveira
During the outbreak of the Zika virus, Brazilian health authorities recommended that pregnant women take meticulous precaution to avoid mosquito bites and that women in general use contraceptive methods to postpone/delay pregnancies. In this article, we present new estimates on the Zika virus incidence, its correlates and preventive behaviors in the Northeast of Brazil, where the outbreak initiated, using survey data collected between March 30th and June 3rd of 2016. The target population were women aged 15-49 in the capital cities of the nine states of the Northeast region of Brazil...
May 1, 2018: Economics and Human Biology
https://www.readbyqxmd.com/read/29771503/internal-electric-field-modulation-in-molecular-electronic-devices-by-atmosphere-and-mobile-ions
#16
Prakash Chandra Mondal, Ushula M Tefashe, Richard L McCreery
The internal potential profile and electric field are major factors controlling the electronic behavior of molecular electronic junctions consisting of ~1-10 nm thick layers of molecules oriented in parallel between conducting contacts. The potential profile is assumed linear in the simplest cases, but can be affected by internal dipoles, charge polarization, and electronic coupling between the contacts and the molecular layer. Electrochemical processes in solutions or solid state are entirely dependent on modification of the electric field by electrolyte ions, which screen the electrodes and form the ionic double layers which are fundamental to electrode kinetics and widespread applications...
May 17, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29770516/personal-network-characteristics-as-predictors-of-change-in-obesity-risk-behaviors-in-early-adolescence
#17
Jennifer Marks, Kayla de la Haye, Lisa M Barnett, Steven Allender
The potential for peers to influence obesity risk behavior increases in adolescence, yet there are knowledge gaps of how behaviors are modified in response to peers over time. This study examined how personal friendship network characteristics were associated with obesity-related behaviors from late childhood to early adolescence. Two waves of friendship, physical activity, screen time, and dietary recall data were collected from 11- to 13-year-old students (99% retention) in Australia (n = 308) over a five- to eight-month period...
May 17, 2018: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29770340/diabetes-related-distress-assessment-among-type-2-diabetes-patients
#18
Majed O Aljuaid, Abdulmajeed M Almutairi, Mohammed A Assiri, Dhifallah M Almalki, Khaled Alswat
Background and Objectives: Diabetes is one of the most common chronic diseases; it is a debilitating and hard to live with. Diabetes-related distress (DRD) refers to the emotional and behavioral changes caused by diabetes. Our study aims to assess the prevalence of DRD among type 2 diabetes (T2D) patients using Diabetes Distress Scale-17 items (DDS-17) and its relation to complications and treatment modalities. Methods: A cross-sectional study of adult T2D patients with follow-up visits at the Diabetes and Endocrinology Center in Taif, Saudi Arabia, between January and July 2017...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29770246/development-of-the-imb-model-and-an-evidence-based-diabetes-self-management-mobile-application
#19
Eunjoo Jeon, Hyeoun-Ae Park
Objectives: This study developed a diabetes self-management mobile application based on the information-motivation-behavioral skills (IMB) model, evidence extracted from clinical practice guidelines, and requirements identified through focus group interviews (FGIs) with diabetes patients. Methods: We developed a diabetes self-management (DSM) app in accordance with the following four stages of the system development life cycle. The functional and knowledge requirements of the users were extracted through FGIs with 19 diabetes patients...
April 2018: Healthcare Informatics Research
https://www.readbyqxmd.com/read/29769289/metarrestin-a-perinucleolar-compartment-inhibitor-effectively-suppresses-metastasis
#20
Kevin J Frankowski, Chen Wang, Samarjit Patnaik, Frank J Schoenen, Noel Southall, Dandan Li, Yaroslav Teper, Wei Sun, Irawati Kandela, Deqing Hu, Christopher Dextras, Zachary Knotts, Yansong Bian, John Norton, Steve Titus, Marzena A Lewandowska, Yiping Wen, Katherine I Farley, Lesley Mathews Griner, Jamey Sultan, Zhaojing Meng, Ming Zhou, Tomas Vilimas, Astin S Powers, Serguei Kozlov, Kunio Nagashima, Humair S Quadri, Min Fang, Charles Long, Ojus Khanolkar, Warren Chen, Jinsol Kang, Helen Huang, Eric Chow, Esthermanya Goldberg, Coral Feldman, Romi Xi, Hye Rim Kim, Gary Sahagian, Susan J Baserga, Andrew Mazar, Marc Ferrer, Wei Zheng, Ali Shilatifard, Jeffrey Aubé, Udo Rudloff, Juan Jose Marugan, Sui Huang
Metastasis remains a leading cause of cancer mortality due to the lack of specific inhibitors against this complex process. To identify compounds selectively targeting the metastatic state, we used the perinuclear compartment (PNC), a complex nuclear structure associated with metastatic behaviors of cancer cells, as a phenotypic marker for a high-content screen of over 140,000 structurally diverse compounds. Metarrestin, obtained through optimization of a screening hit, disassembles PNCs in multiple cancer cell lines, inhibits invasion in vitro, suppresses metastatic development in three mouse models of human cancer, and extends survival of mice in a metastatic pancreatic cancer xenograft model with no organ toxicity or discernable adverse effects...
May 16, 2018: Science Translational Medicine
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