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https://www.readbyqxmd.com/read/29456775/interethnic-variations-and-clinical-features-of-spondyloarthropathies-in-a-middle-eastern-country
#1
Mohammed Kamil Quraishi, Humeira Badsha, Bhavna Khan, Muhammad Shahzeb, Srilakshmi Hegde, Ayman Mofti, Kong Kok Ooi
Objectives: The study aimed to demonstrate the interethnic differences and clinical features of Spondyloarthropathy(SpA) patients in a diverse Middle Eastern Country. Methods: A retrospective review of medical records to collect the required data was conducted for SpA patients at two study institutions in the United Arab Emirates. Results: Of 141 SpA patients found, 88 AS(Ankylosing Spondylitis) patients and 53 'other SpA' patients were identified...
2018: Open Rheumatology Journal
https://www.readbyqxmd.com/read/29455266/inflammatory-tenosynovitis-and-enthesitis-induced-by-immune-checkpoint-inhibitor-treatment
#2
Jun Inamo, Yuko Kaneko, Tsutomu Takeuchi
Reports about immune-related adverse events (IrAEs) induced by immune checkpoint inhibitors (ICIs) have been increasing. Although the importance of understanding joint involvement and myalgia as an IrAE has grown, little is known about its characteristics. The aim of this study was to investigate the incidence and clinical characteristics of articular IrAEs. We reviewed 133 patients who were treated with ICIs in our institution and referred to our rheumatologic. Among them, 2 (1.5%) developed arthritis during the use of anti-PD-1 inhibitor, and there was one patient with joint pain after anti-PD-L1 inhibitor who was referred to our department from another institution...
February 17, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29452306/boundaries-between-familial-mediterranean-fever-and-juvenile-spondyloarthritis-analysis-of-three-french-retrospective-cohorts
#3
Bilade Cherqaoui, Linda Rossi-Semerano, Sophie Georgin-Lavialle, Perrine Dusser, Caroline Galeotti, Maryam Piram, Véronique Hentgen, Isabelle Touitou, Isabelle Koné-Paut
OBJECTIVES: Children with Familial Mediterranean fever may suffer from musculoskeletal involvement, somewhat difficult to distinguish from juvenile spondyloarthritis. The association of these two diseases has been scarcely reported in children. Objectives of this work were to define the association of familial Mediterranean fever and juvenile spondyloarthritis in France. METHODS: Three cohorts of children with familial Mediterranean fever, juvenile spondyloarthritis, familial Mediterranean fever related juvenile spondyloarthritis, were retrospectively identified in the French reference center of auto-inflammatory diseases...
February 13, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29449506/whole-body-magnetic-resonance-imaging-in-axial-spondyloarthritis-reduction-of-sacroiliac-spinal-and-entheseal-inflammation-in-a-placebo-controlled-trial-of-adalimumab
#4
Simon Krabbe, Mikkel Østergaard, Iris Eshed, Inge J Sørensen, Bente Jensen, Jakob M Møller, Lone Balding, Ole R Madsen, Karsten Asmussen, Grith Eng, Niklas R Jørgensen, Susanne J Pedersen
OBJECTIVE: To investigate whether adalimumab (ADA) reduces whole-body (WB-) magnetic resonance imaging (MRI) indices for inflammation in the entheses, peripheral joints, sacroiliac joints, spine, and the entire body in patients with axial spondyloarthritis (axSpA). METHODS: An investigator-initiated, randomized, placebo-controlled, double-blinded 48-week followup trial included 49 patients with axSpA, who had Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29439292/augmented-th17-differentiation-leads-to-cutaneous-and-synovio-entheseal-inflammation-in-a-novel-model-of-psoriatic-arthritis
#5
Lu Yang, Melania H Fanok, Aranzazu Mediero-Munoz, Laura K Fogli, Carmen Corciulo, Shahla Abdollahi, Bruce N Cronstein, Jose U Scher, Sergei B Koralov
OBJECTIVE: To introduce a novel pre-clinical animal model of psoriatic arthritis, R26STAT3C stopfl/fl CD4Cre mice, and investigate the role of Th17 cytokines in the disease pathogenesis. METHODS: We characterized a novel murine model of Th17-driven cutaneous and synovio-entheseal disease directed by T cell-specific expression of a hyperactive STAT3 allele. By crossing R26STAT3C stopfl/fl CD4Cre mice onto an IL-22 knockout background or treating them with a neutralizing antibody against IL-17, we interrogated how these Th17 cytokines contribute to disease pathogenesis...
February 13, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29432755/pelvic-muscles-mechanical-response-to-strains-in-the-absence-and-presence-of-pregnancy-induced-adaptations-in-a-rat-model
#6
Tatiana Catanzarite, Shannon Bremner, Caitlin L Barlow, Laura Bou-Malham, Shawn O'Connor, Marianna Alperin
BACKGROUND: Maternal birth trauma to the pelvic floor muscles is thought to be consequent to mechanical demands placed on these muscles during fetal delivery that exceed muscle physiological limits. The above is consistent with studies of striated limb muscles that identify hyperelongation of sarcomeres, the functional muscle units, as the primary cause of mechanical muscle injury and resultant muscle dysfunction. However, pelvic floor muscles' mechanical response to strains have not been examined at a tissue level...
February 9, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29429762/enthesitis-a-hallmark-of-psoriatic-arthritis
#7
REVIEW
Gurjit S Kaeley, Lihi Eder, Sibel Z Aydin, Marwin Gutierrez, Catherine Bakewell
OBJECTIVE: To describe the growing importance of enthesitis in patients with psoriatic arthritis (PsA) and discuss the advantages and disadvantages of clinical and imaging methods currently used to assess enthesitis. METHODS: PubMed literature searches were conducted using the terms psoriatic arthritis, entheses, enthesitis, pathology, imaging, ultrasound, magnetic resonance imaging, clinical, and indices. Articles were deemed relevant if they provided insight into the pathology, monitoring, and/or diagnosis of enthesitis in PsA, or if they discussed clinical or imaging indices used to assess enthesitis...
January 6, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29425183/role-of-the-il-23-il-17-axis-in-psoriasis-and-psoriatic-arthritis-the-clinical-importance-of-its-divergence-in-skin-and-joints
#8
REVIEW
Marie-Astrid Boutet, Alessandra Nerviani, Gabriele Gallo Afflitto, Costantino Pitzalis
Psoriasis is a chronic systemic inflammatory disease causing erythematosus and scaly skin plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is characterised by inflammation and progressive damage of the peripheral joints and/or the spine and/or the entheses. The pathogenic mechanisms driving the skin disorder in psoriasis and the joint disease in PsA are sustained by the activation of inflammatory pathways that can be overlapping, but also, at least partially, distinct. Cytokines members of the IL-23/IL-17 family, critical in the development of autoimmunity, are abundantly expressed within the cutaneous lesions but also seem to be involved in chronic inflammation and damage of the synovium though, as it will be here discussed, not in all patients...
February 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29419448/the-sex-influence-on-response-to-tumor-necrosis-factor-%C3%AE-inhibitors-and-remission-in-axial-spondyloarthritis
#9
Ennio Lubrano, Fabio Massimo Perrotta, Maria Manara, Salvatore D'Angelo, Olga Addimanda, Roberta Ramonda, Leonardo Punzi, Ignazio Olivieri, Carlo Salvarani, Antonio Marchesoni
OBJECTIVE: The aim of this study was to evaluate the influence of sex on response to treatment and disease remission in patients with axial spondyloarthritis (axSpA). METHODS: In this retrospective multicenter study, patients with axSpA, according to the Assessment of Spondyloarthritis international Society (ASAS) criteria for axSpA, and treated with adalimumab, etanercept, golimumab, or infliximab, were studied. We compared clinical characteristics, patient-reported outcomes, disease activity, function, and response to treatment in male and female patients with this disease...
February 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29411182/drug-survival-and-effectiveness-of-ustekinumab-in-patients-with-psoriatic-arthritis-real-life-data-from-the-biologic-apulian-registry-biopure
#10
Florenzo Iannone, Leonardo Santo, Romano Bucci, Angelo Semeraro, Giorgio Carlino, Franco Paoletti, Laura Quarta, Pierfrancesco Leucci, Carmelo Zuccaro, Antonio Marsico, Crescenzio Scioscia, Francesca D'Onofrio, Daniela Mazzotta, Maurizio Muratore, Francesco Paolo Cantatore, Giovanni Lapadula
This study aims to evaluate the drug survival and effectiveness of ustekinumab in psoriatic arthritis (PsA) patients naïve to biologics or inadequate responders to tumor necrosis factor (TNF-IR) inhibitors in real life. PsA patients starting ustekinumab were enrolled from 2014 to 2016. Joint involvement, peripheral or axial, Psoriatic Area Severity Index, Disease Activity Psoriatic Arthritis (DAPSA), Lee Enthesitis Index, Health Assessment Questionnaire, body mass index, comorbidities, co-therapies, mechanism of action, and causes of discontinuation of prior TNFi were collected at baseline, and 6 and 12 months...
February 7, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29407043/2017-update-of-french-society-for-rheumatology-sfr-recommendations-about-the-everyday-management-of-patients-with-spondyloarthritis
#11
Daniel Wendling, Cédric Lukas, Clément Prati, Pascal Claudepierre, Laure Gossec, Philippe Goupille, Christophe Hudry, Corinne Miceli-Richard, Anna Molto, Thao Pham, Alain Saraux, Maxime Dougados
OBJECTIVE: To update French Society for Rheumatology recommendations about the management in clinical practice of patients with spondyloarthritis (SpA). SpA is considered across the range of clinical phenotypes (axial, peripheral, and entheseal) and concomitant manifestations. Psoriatic arthritis is included among the SpA phenotypes. METHODS: According to the standard procedure advocated by the EULAR for developing recommendations, we first reviewed the literature published since the previous version of the recommendations issued in June 2013...
January 30, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29400373/diagnostic-value-of-musculoskeletal-ultrasound-in-patients-with-low-back-pain-a-review-of-the-literature
#12
REVIEW
Plamen Todorov Todorov, Rodina Nestorova, Anastas Batalov
Patients with low back pain (LBP) frequently undergo various imaging studies in the pursuit of a more precise diagnosis. Ultrasound (US) has the advantage of being a widely available, multiplanar, fast and radiation-free diagnostic tool. Moreover, compared to most of the other imaging modalities, it is particularly efficient in the visualization and assessment of soft tissues. Consequently, the question about the possible diagnostic application of US in such a common pathology as LBP is very relevant to the clinical practice...
February 4, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29399778/a-repeatable-geometric-morphometric-approach-to-the-analysis-of-hand-entheseal-three-dimensional-form
#13
Fotios Alexandros Karakostis, Gerhard Hotz, Heike Scherf, Joachim Wahl, Katerina Harvati
OBJECTIVES: The purpose of this study was to put forth a precise landmark-based technique for reconstructing the three-dimensional shape of human entheseal surfaces, to investigate whether the shape of human entheses is related to their size. The effects of age-at-death and bone length on entheseal shapes were also assessed. MATERIALS AND METHODS: The sample comprised high-definition three-dimensional models of three right hand entheseal surfaces, which correspond to 45 male adult individuals of known age...
February 5, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29393349/enhancement-of-tendon%C3%A2-bone-healing-following-rotator-cuff-repair-using-hydroxyapatite-with-tgf%C3%AE-1
#14
Xiebo You, Yueqin Shen, Weihan Yu, Yaohua He
The formation of fibrocartilage at the healing site following a rotator cuff tear repair is a major problem in the field of tendon‑bone healing. The present study aimed to enhance the healing of the tendon‑bone interface following rotator‑cuff tear repair by the interposition of hydroxyapatite (HA) encapsulated with transforming growth factor β1 (TGFβ1). Using an acute rotator cuff repair model, rats were divided into three groups: i) Repair only (control); ii) HA group; and iii) HA‑TGFβ1 group...
January 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29382366/age-and-fecal-microbial-strain-specific-differences-in-patients-with-spondyloarthritis
#15
Matthew L Stoll, Pamela F Weiss, Jennifer E Weiss, Peter A Nigrovic, Barbara S Edelheit, S Lou Bridges, Maria I Danila, Charles H Spencer, Marilynn G Punaro, Kenneth Schikler, Andreas Reiff, Ranjit Kumar, Randy Q Cron, Casey D Morrow, Elliot J Lefkowitz
BACKGROUND: Prior studies have demonstrated abnormalities in the composition of the gastrointestinal microbiota in pediatric and adult patients with spondyloarthritis (SpA). In particular, diminished fecal abundance of Faecalibacterium prausnitzii and abnormalities in both directions in the abundance of the Bacteroides genus have been identified. METHODS: We obtained fecal specimens from 30 children with treatment-naïve enthesitis-related arthritis (ERA) and 19 healthy controls, as well as specimens from 11 adult patients with longstanding SpA and 10 adult healthy controls...
January 30, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29364757/a-force-on-the-crown-and-tug-of-war-in-the-periodontal-complex
#16
A T Jang, L Chen, A R Shimotake, W Landis, V Altoe, S Aloni, M Ryder, S P Ho
The load-bearing dentoalveolar fibrous joint is composed of biomechanically active periodontal ligament (PDL), bone, cementum, and the synergistic entheses of PDL-bone and PDL-cementum. Physiologic and pathologic loads on the dentoalveolar fibrous joint prompt natural shifts in strain gradients within mineralized and fibrous tissues and trigger a cascade of biochemical events within the widened and narrowed sites of the periodontal complex. This review highlights data from in situ biomechanical simulations that provide tooth movements relative to the alveolar socket...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29361203/the-association-between-hla-genetic-susceptibility-markers-and-sonographic-enthesitis-in-psoriatic-arthritis
#17
Ari Polachek, Richard Cook, Vinod Chandran, Fatima Abji, Dafna Gladman, Lihi Eder
OBJECTIVE: Enthesitis is an important pathophysiologic component in psoriatic arthritis (PsA). Human Leukocyte Antigen (HLA) genes are implicated in the pathogenesis of PsA. Little is known about the relation between HLA genetic susceptibility markers and enthesitis in PsA patients. Our aim was to examine the association between HLA genetic susceptibility markers and sonographic enthesitis in PsA. METHODS: A cross-sectional analysis was conducted in patients with PsA...
January 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29346195/the-entheseal-signature-of-erosive-arthritis-surface-microscopy-of-achilles-tendon-insertions-into-bone
#18
Bruce M Rothschild
No abstract text is available yet for this article.
January 9, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29343507/early-and-sustained-efficacy-with-apremilast-monotherapy-in-biological-na%C3%A3-ve-patients-with-psoriatic-arthritis-a-phase-iiib-randomised-controlled-trial-active
#19
Peter Nash, Kamal Ohson, Jessica Walsh, Nikolay Delev, Dianne Nguyen, Lichen Teng, Juan J Gómez-Reino, Jacob A Aelion
OBJECTIVE: Evaluate apremilast efficacy across various psoriatic arthritis (PsA) manifestations beginning at week 2 in biological-naïve patients with PsA. METHODS: Patients were randomised (1:1) to apremilast 30 mg twice daily or placebo. At week 16, patients whose swollen and tender joint counts had not improved by ≥10% were eligible for early escape. At week 24, all patients received apremilast through week 52. RESULTS: Among 219 randomised patients (apremilast: n=110; placebo: n=109), a significantly greater American College of Rheumatology 20 response at week 16 (primary outcome) was observed with apremilast versus placebo (38...
January 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29333332/next-generation-tissue-engineering-of-orthopedic-soft-tissue-to-bone-interfaces
#20
Alexander J Boys, Mary Clare McCorry, Scott Rodeo, Lawrence J Bonassar, Lara A Estroff
Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues...
September 2017: MRS Communications
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