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https://www.readbyqxmd.com/read/28426894/characteristics-and-course-of-enthesitis-in-a-juvenile-idiopathic-arthritis-inception-cohort
#1
Dax G Rumsey, Jaime Guzman, Alan M Rosenberg, Adam M Huber, Rosie Scuccimarri, Natalie J Shiff, Alessandra Bruns, Brian M Feldman, Dean T Eurich
Objective To describe the prevalence, associated characteristics, and course of enthesitis in a juvenile idiopathic arthritis (JIA) inception cohort. Methods Canadian children newly diagnosed with JIA between 2005 and 2010 were categorized using ILAR criteria at the 6-month visit and followed in the ReACCh-Out cohort for up to 5 years. The presence of entheseal tenderness on examination at 33 sites shown on a homunculus was recorded at 0, 6, 12, 18, 24, 36, 48 and 60 months after enrolment. Enthesitis was defined as entheseal tenderness at more than one site or on more than one occasion...
April 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28418334/juvenile-idiopathic-arthritis
#2
Kenan Barut, Amra Adrovic, Sezgin Şahin, Özgür Kasapçopur
Juvenile idiopathic arthritis is the most common chronic rheumatic disease of unknown aetiology in childhood and predominantly presents with peripheral arthritis. The disease is divided into several subgroups, according to demographic characteristics, clinical features, treatment modalities and disease prognosis. Systemic juvenile idiopathic arthritis, which is one of the most frequent disease subtypes, is characterized by recurrent fever and rash. Oligoarticular juvenile idiopathic arthritis, common among young female patients, is usually accompanied by anti-nuclear antibodie positivity and anterior uveitis...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28413624/recent-advances-in-understanding-spondyloarthritis
#3
REVIEW
J S H Gaston
This review is concerned with a number of recent publications that contribute to current thinking on the pathogenesis of spondyloarthritis. The areas covered include the lymphocyte population in the enthesis, which is thought to drive enthesitis, and hence clinical manifestations. The debate on how HLA-B27 is implicated in inflammation is also considered, together with recent and contradictory evidence on the effects of the peptide-trimming enzyme ERAP1 on B27 expression and hence susceptibility to spondylitis...
2017: F1000Research
https://www.readbyqxmd.com/read/28413099/second-line-biologic-therapy-optimization-in-rheumatoid-arthritis-psoriatic-arthritis-and-ankylosing-spondylitis
#4
REVIEW
Fabrizio Cantini, Laura Niccoli, Carlotta Nannini, Emanuele Cassarà, Olga Kaloudi, Ennio Giulio Favalli, Andrea Becciolini, Maurizio Benucci, Francesca Li Gobbi, Serena Guiducci, Rosario Foti, Marta Mosca, Delia Goletti
OBJECTIVE: The Italian board for the TAilored BIOlogic therapy (ITABIO) reviewed the most consistent literature to indicate the best strategy for the second-line biologic choice in patients with rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA). METHODS: Systematic review of the literature to identify English-language articles on efficacy of second-line biologic choice in RA, PsA, and ankylosing spondylitis (AS). Data were extracted from available randomized, controlled trials, national biologic registries, national healthcare databases, post-marketing surveys, and open-label observational studies...
March 22, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28412702/case-control-study-on-dactylitis-enthesitis-and-anterior-uveitis-in-spondyloarthritis-associated-with-inflammatory-bowel-diseases-role-of-coexistent-psoriasis
#5
Fabrizio Cantini, Laura Niccoli, Carlotta Nannini, Emanuele Cassarà, Olga Kaloudi, Fernando Rizzello, Paolo Gionchetti
OBJECTIVE: To evaluate the frequency of dactylitis, enthesitis, and anterior uveitis (AU) in spondyloarthritis (SpA) associated with inflammatory bowel disease (IBD-SpA) compared with other SpA, and to assess the role of associated psoriasis in the occurrence of dactylitis and enthesitis. METHODS: In a 12-month case-control study, the frequency of dactylitis and enthesitis in 29 patients with ulcerative colitis (UC) and 59 with Crohn disease (CD) who satisfied the Spondyloarthritis international Society criteria for axial or peripheral SpA was compared with 176 controls, including 97 (55...
April 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28405472/course-of-patients-with-juvenile-spondyloarthritis-during-4%C3%A2-years-of-observation-juvenile-part-of-gespic
#6
Anja Weiß, Kirsten Minden, Joachim Listing, Ivan Foeldvari, Joachim Sieper, Martin Rudwaleit
OBJECTIVE: To describe the course and the 4-year outcome of juvenile spondyloarthritis (jSpA). METHODS: Patients with a diagnosis of jSpA and an age at onset ≤16 years were included in the German Spondyloarthritis Inception cohort (GESPIC) and followed up prospectively for 4 years. RESULTS: 118 patients (73% men, 66% HLA-B27 positive, mean age 13.5 years, mean symptom duration 2.2 years) were enrolled in 2 study centres: 52% of patients with jSpA were captured by the enthesitis-related arthritis subgroup of the International League of Associations for Rheumatology classification criteria...
2017: RMD Open
https://www.readbyqxmd.com/read/28393709/profile-of-patients-with-spondyloarthritis-in-morocco
#7
Jamila Essouiri, Abourazzak Fatima Ezzahra, Kona Irene, Khoussar Ikram, Harzy Taoufik
OBJECTIVES: to describe the characteristics of our population with spondyloarthritis: diagnostic time, clinical manifestations and laboratory investigations, activity, functional impairment, severity and therapeutic management. The authors were also interested to investigate factors associated with severe disease. METHODS: A retrospective observational study, conducted in the rheumatology department at university hospital center Hassan II of Fez, analyzing the records of patients diagnosed as spondylarthritis during the period extending from January 2009 to June 2014...
April 6, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28387854/the-problem-in-differentiation-between-psoriatic-related-polyenthesitis-and-fibromyalgia
#8
Antonio Marchesoni, Gabriele De Marco, Mira Merashli, Frank McKenna, Ilaria Tinazzi, Helena Marzo-Ortega, Dennis G McGonagle
The recognition of the primacy of enthesitis in animal models of spondyloarthritis and the prevalence of clinically occult enthesopathy in psoriatic subjects and of persistent joint pain in PsA subjects who have ostensibly good reduction of joint swelling under biological therapy has highlighted the potential impact of polyenthesitis in psoriatic disease. In daily practice, the formal demonstration of enthesitis is challenging for the following reasons: the relatively avascular nature of enthesis, often leading to the absence of overt clinical inflammatory signs; the frequent lack of elevation of inflammatory markers; and finally, the limitations of current imaging techniques to provide supportive evidence for inflammation in these areas...
April 5, 2017: Rheumatology
https://www.readbyqxmd.com/read/28380667/antibodies-to-citrullinated-peptides-in-patients-with-juvenile-idiopathic-arthritis-and-rheumatoid-arthritis-shared-expression-of-the-inherently-autoreactive-9g4-idiotype
#9
Hannah Peckham, Geraldine Cambridge, Lauren Bourke, Debajit Sen, Anna Radziszewska, Maria Leandro, Yiannis Ioannou
Objective Antibodies to cyclic citrullinated peptides (CCP) in rheumatoid arthritis (RA) can express the inherently autoreactive gene, VH4-34, as detected using the rat monoclonal antibody, 9G4. Patients with the polyarticular sub-type of juvenile idiopathic arthritis (pJIA) share some but not all features of RA in adults. The aim of this study was to profile rheumatoid factor (RF), anti-CCP and 9G4-CCP serology of a large JIA cohort and compare to a cohort of adult RA patients. Methods Serum from 88 pJIA, 29 enthesitis-related arthritis (ERA), 38 extended oligoarthritis (EOA), 31 adolescent controls, 35 RA and 30 adult controls were tested for RF, IgG, IgA and IgM anti-CCP and 9G4+CCP by ELISA...
April 5, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28378489/subclinical-enthesitis-in-nail-psoriasis-patients-a-case-control-study
#10
Karlijn M G Klaassen, Marieke J M Ploegmakers, Peter C M van de Kerkhof, Willemijn M Klein, Marcel C Pasch
BACKGROUND: Patients with nail psoriasis have a higher prevalence of psoriatic arthritis; however, the pathogenetic relationship between these two disorders is as yet unclear. Entheses have been suggested as disease epicenter, which might explain the pathogenesis on an anatomical level. OBJECTIVE: To contribute to the elucidation of the hypothesis as regards the anatomical link between nail psoriasis and psoriatic arthritis, with the extensor enthesis of the distal interphalangeal joint as the epicenter...
April 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28378478/subklinische-enthesitis-bei-nagelpsoriasis-patienten-eine-fall-kontroll-studie
#11
Karlijn M G Klaassen, Marieke J M Ploegmakers, Peter C M van de Kerkhof, Willemijn M Klein, Marcel C Pasch
No abstract text is available yet for this article.
April 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28376239/clinical-characteristics-disease-activity-and-patient-reported-outcomes-in-psoriatic-arthritis-patients-with-dactylitis-or-enthesitis-results-from-the-corrona-psoriatic-arthritis-spondyloarthritis-registry
#12
Philip J Mease, Chitra Karki, Jacqueline B Palmer, Carol J Etzel, Arthur Kavanaugh, Christopher T Ritchlin, Wendi Malley, Vivian Herrera, Melody Tran, Jeffrey D Greenberg
OBJECTIVE: Characterize psoriatic arthritis (PsA) patients with dactylitis or enthesitis and evaluate the associations of these manifestations with disease activity and patient-reported outcomes. METHODS: Using the Corrona PsA/Spondyloarthritis Registry, patient characteristics, disease activity, and patient-reported outcomes at registry enrollment were assessed for PsA patients aged ≥ 18 years with or without dactylitis or enthesitis. Regression models were used to evaluate associations of dactylitis and enthesitis with outcomes including Minimal Disease Activity, Health Assessment Questionnaire scores, patient-reported pain and fatigue, and work productivity (Work Productivity and Activity Impairment questionnaire)...
April 4, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28371859/classification-criteria-for-diffuse-idiopathic-skeletal-hyperostosis-a-lack-of-consensus
#13
Jonneke S Kuperus, Erin E A de Gendt, F Cumhur Oner, Pim A de Jong, Stan C F M Buckens, Alie E van der Merwe, George J R Maat, Elizabeth A Regan, Donald L Resnick, Reuven Mader, Jorrit-Jan Verlaan
Objectives.: DISH is a condition characterized by flowing ossifications of the spine with or without ossifications of entheses elsewhere in the body. Studies on the prevalence and pathogenesis of DISH use a variety of partly overlapping combinations of classification criteria, making meaningful comparisons across the literature difficult. The aim of this study was to systematically summarize the available criteria to support the development of a more uniform set of diagnostic/classification criteria...
March 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/28364275/magnetic-resonance-imaging-in-diffuse-idiopathic-skeletal-hyperostosis-similarities-to-axial-spondyloarthritis
#14
Uri Arad, Ori Elkayam, Iris Eshed
Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory condition that involves calcification and ossification of the spinal ligaments and entheses. While, characteristic magnetic resonance imaging (MRI) lesions of the spine in patients with axial spondyloarthritis, another enthesitis-related disease, have been described and defined, there is a paucity of information regarding the MRI findings in DISH. The aim of this study was to describe the MRI findings of patients with DISH. We collected computed tomography studies with findings characteristic of DISH and that also had corresponding and concurrent MRI studies of the spine...
March 31, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28358891/plantar-fascia-enthesopathy-is-highly-prevalent-in-diabetic-patients-without-peripheral-neuropathy-and-correlates-with-retinopathy-and-impaired-kidney-function
#15
Francesco Ursini, Franco Arturi, Kassandra Nicolosi, Antonio Ammendolia, Salvatore D'Angelo, Emilio Russo, Saverio Naty, Caterina Bruno, Giovambattista De Sarro, Ignazio Olivieri, Rosa Daniela Grembiale
BACKGROUND: Aim of this study was to evaluate the prevalence of plantar fascia (PF) enthesopathy in Type 2 diabetes mellitus (T2DM) patients without distal peripheral neuropathy (DPN). METHODS: We recruited 50 T2DM patients without DPN and 50 healthy controls. DPN was excluded using the Michigan Neuropathy Screening Instrument (MNSI). All patients underwent a bilateral sonographicevaluation of the enthesealportion of the PF. RESULTS: PF thickness was significantly higher in T2DM patients (p<0...
2017: PloS One
https://www.readbyqxmd.com/read/28329487/apremilast-for-the-treatment-of-psoriatic-arthritis
#16
Brent C Martin, Logan W Thomas, Francis J Dann
Psoriatic arthritis (PsA) is a chronic inflammatoryarthropathy that affects joints and entheses andis associated with psoriasis (PsO). There are fiveclinical patterns of PsA: symmetrical polyarthritis,distal interphalangeal arthropathy, asymmetricaloligoarthritis, arthritis mutilans, and spondylitis, withor without sacroiliitis. Concerning PsA, the goals oftherapy are to control inflammation, prevent articulardamage, and reduce discomfort in the affected joints.Although there are many therapeutic options forthe treatment of PsAs, physicians most often beginwith nonsteroidal anti-inflammatory drugs (NSAIDs)for mild disease...
February 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28327634/scleraxis-is-required-for-maturation-of-tissue-domains-for-proper-integration-of-the-musculoskeletal-system
#17
Yuki Yoshimoto, Aki Takimoto, Hitomi Watanabe, Yuji Hiraki, Gen Kondoh, Chisa Shukunami
Scleraxis (Scx) is a basic helix-loop-helix transcription factor that is expressed persistently in tendons/ligaments, but transiently in entheseal cartilage. In this study, we generated a novel Scx(Cre) knock-in (KI) allele, by in-frame replacement of most of Scx exon 1 with Cre recombinase (Cre), to drive Cre expression using Scx promoter and to inactivate the endogenous Scx. Reflecting the intensity and duration of endogenous expression, Cre-mediated excision occurs in tendinous and ligamentous tissues persistently expressing Scx...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28320454/mitigation-of-disease-and-treatment-related-risks-in-patients-with-psoriatic-arthritis
#18
REVIEW
Martin Bergman, Amy Lundholm
Psoriatic arthritis is a part of the family of diseases referred to as spondyloarthropathies, a diverse group of chronic inflammatory disorders with common clinical, radiographic, and genetic features. Peripheral arthritis is the most common symptom of psoriatic arthritis and patients also frequently experience involvement of the entheses, spine, skin, and nails. Due to the diverse clinical spectrum of disease severity, tissues affected, and associated comorbidities, the treatment of psoriatic arthritis can be challenging and it is necessary to mitigate risks associated with both the disease and its treatment...
March 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28303758/beneficial-effect-of-n-3-polyunsaturated-fatty-acids-on-inflammation-and-analgesic-use-in-psoriatic-arthritis-a-randomized-double-blind-placebo-controlled-trial
#19
S Kristensen, E B Schmidt, A Schlemmer, C Rasmussen, M B Johansen, J H Christensen
OBJECTIVE: This study aimed to investigate the effects of marine n-3 polyunsaturated fatty acids (PUFAs) on disease activity, use of analgesics, and inflammatory biomarkers in patients with psoriatic arthritis (PsA). METHOD: Patients with established PsA (n = 145) were investigated in a randomized, double-blind, placebo-controlled study. The participants received a supplement of 3 g n-3 PUFA/day or 3 g olive oil/day (control) for 24 weeks. Outcome measures for disease activity, use of analgesics, and leukotriene formation from activated granulocytes were assessed at baseline and at study end...
March 17, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28298566/ultrasound-evaluation-of-the-entheses-in-daily-clinical-practice-during-tumor-necrosis-factor-%C3%AE-blocking-therapy-in-patients-with-ankylosing-spondylitis
#20
Fréke Wink, George A Bruyn, Fiona Maas, Ed N Griep, Eveline van der Veer, Hendrika Bootsma, Elisabeth Brouwer, Suzanne Arends, Anneke Spoorenberg
OBJECTIVE: To assess structural and inflammatory ultrasound (US) lesions of entheses in ankylosing spondylitis (AS) patients with active disease and to evaluate inflammatory lesions after 6 months of tumor necrosis factor (TNF-α) blocking therapy, in daily clinical practice. METHODS: Consecutive patients with AS were clinically evaluated and underwent US examination of 9 bilateral entheses before and after 6 months of TNF-α blocking therapy. US examination included the following as inflammatory lesions: bone erosions/cortical irregularities, enthesophytes, calcifications as structural lesions; adjacent bursitis, effusion, increased tendon hypoechogenicity or thickness; and positive power Doppler (PD) signal...
March 15, 2017: Journal of Rheumatology
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