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https://www.readbyqxmd.com/read/28089501/effectiveness-of-conventional-disease-modifying-antirheumatic-drugs-in-psoriatic-arthritis-a-systematic-review
#1
Jesús Maese, Petra Díaz Del Campo, Daniel Seoane-Mato, Mercedes Guerra, Juan D Cañete
BACKGROUND: Due to the clinical heterogeneity of psoriatic arthritis (PsA), recommendations have been developed by international groups to guide therapeutic decisions of the rheumatologist. The objective of the current systematic review (RS) was to evaluate the evidence of efficacy of disease-modifying antirheumatic drugs (DMARDs) in PsA. METHODS: Literature search in Medline, EMBASE, Cochrane Library, from 2008 to 2014. We included RS, randomized clinical trials and observational studies, in patients with PsA and an evaluation of efficiency of conventional DMARDs (methotrexate, sulfasalazine, leflunomide), according to the following outcomes: peripheral and axial symptoms; peripheral radiological damage; enthesitis according to power Doppler ultrasound or magnetic resonance imaging (enthesitis count before and after therapy); dactylitis; uveitis...
January 12, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28088669/micro-mechanical-properties-of-the-tendon-to-bone-attachment
#2
Alix C Deymier, Yiran An, John J Boyle, Andrea G Schwartz, Victor Birman, Guy M Genin, Stavros Thomopoulos, Asa H Barber
: The tendon-to-bone attachment (enthesis) is a complex hierarchical tissue that connects stiff bone to compliant tendon. The attachment site at the micrometer scale exhibits gradients in mineral content and collagen orientation, which likely act to minimize stress concentrations. The physiological micromechanics of the attachment thus define resultant performance, but difficulties in sample preparation and mechanical testing at this scale have restricted understanding of structure-mechanical function...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28070627/-tendinopathy-in-rheumatic-diseases
#3
M Henniger, S Rehart
Involvement of tendons and tendon sheaths is frequently found in the most common inflammatory systemic diseases, rheumatoid arthritis and spondyloarthritis. In rheumatoid arthritis tendon manifestations occur as tenosynovitis, with swelling and pain of the tendons mainly on the hands and feet. In spondyloarthritis the involvement of tendons presents as enthesitis with pain and swelling directly at the attachment points of tendons to the bony structures and more commonly in the lower extremities. Pathological alterations of tendons can be normally visualized by sonography and only sometimes with magnetic resonance imaging (MRI) or scintigraphy...
January 9, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28056736/investigation-of-associations-between-autoimmunity-associated-variants-in-pdcd1-and-juvenile-idiopathic-arthritis
#4
Christina I Tejeda, K Alaine Broadaway, Milton R Brown, Lori A Ponder, Michael J Ombrello, Mina Rohani Pichavant, Gabriel Wang, Sheila T Angeles-Han, Aimee O Hersh, John F Bohnsack, Karen N Conneely, Michael P Epstein, Sampath Prahalad
PURPOSE: Variants in the gene encoding Programmed Cell Death-1 (PDCD1) have been associated with susceptibility to Systemic Lupus Erythematosus and other autoimmune diseases. Given that clinically distinct autoimmune phenotypes share common genetic susceptibility factors, variants in PDCD-1 were tested for a possible association with Juvenile Idiopathic Arthritis (JIA). METHODS: Four single nucleotide polymorphisms (SNPS) in the PDCD1 gene were genotyped and analyzed: rs10204525, rs7568402, rs7421861 and rs11568821 in 834 cases and 855 self-identified Caucasian controls...
January 4, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28002334/gender-differences-among-patients-with-primary-ankylosing-spondylitis-and-spondylitis-associated-with-psoriasis-and-inflammatory-bowel-disease-in-an-iberoamerican-spondyloarthritis-cohort
#5
Margarita Landi, Hernán Maldonado-Ficco, Rodolfo Perez-Alamino, José A Maldonado-Cocco, Gustavo Citera, Pablo Arturi, Percival D Sampaio-Barros, Diana E Flores Alvarado, Rubén Burgos-Vargas, Elena Santos, Daniel Palleiro, Miguel A Gutiérrez, Elsa Vieyra-Sousa, Fernando Pimentel-Santos, Sergio O Paira, Alberto Berman, Claudia Vera Barrezueta, Janitzia Vazquez-Mellado, Eduardo Collantes-Estevez
The aim of the study was to compare clinical manifestations, disease activity, functional capacity, spinal mobility, and radiological findings between men and women from a multicenter, multiethnic Ibero-American cohort of patients with Spondyloarthritis (SpA).This observational cross-section study included 1264 consecutive SpA patients who fulfilled the modified New York criteria for ankylosing spondylitis (AS). Demographic, clinical, and radiologic data were evaluated. Categorical data were compared by X or Fisher's exact tests and continuous variables by ANOVA with post-hoc tests...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27998042/ultrasound-features-of-the-posterior-tibialis-tendon-and-peroneus-brevis-tendon-entheses-a-comparison-study-between-healthy-adults-and-inflammatory-arthritis
#6
Ian M Ward, Eugene Kissin, Gurjit Kaeley, Joshua N Scott, Michelle Newkirk, Bernard A Hildebrand, Josh Lospinoso, Minna J Kohler, Jay B Higgs
OBJECTIVES: Limited literature exists on the sonographic appearance of the posterior tibialis (PTT) and the peroneus brevis (PBT) tendon entheses. We determined the anatomic features and best imaging techniques of normal PTT and PBT using musculoskeletal ultrasound and compared these findings to subjects with inflammatory arthritis. METHODS: Adult subjects were enrolled as: healthy controls (HC), rheumatoid arthritis (RA), and spondyloarthropathy (SpA). Bilateral PTT and PBT entheses were imaged longitudinally, comparing two angles of insonation: perpendicular to the skin surface and 45˚ cephalad...
December 20, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27998023/clinical-enthesitis-in-a-prospective-longitudinal-psoriatic-arthritis-cohort-incidence-prevalence-characteristics-and-outcome
#7
Ari Polachek, Suzanne Li, Vinod Chandran, Dafna Gladman
OBJECTIVES: The aim of our study was to evaluate the incidence, prevalence, characteristics, disease associations, risk factors and outcome of clinical enthesitis in patients with PsA. METHODS: The study included patients with PsA followed prospectively. Enthesitis was defined as the presence of at least one tender enthesis at one of the 18 entheseal sites of the Spondyloarthritis Research Consortium of Canada enthesitis index. RESULTS: Between 2008 and 2014, 281 of 803 patients had enthesitis providing a prevalence of 35%...
December 20, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27994624/regulatory-mechanisms-of-the-ihh-pthrp-signaling-pathway-in-fibrochondrocytes-in-entheses-of-pig-achilles-tendon
#8
Xuesong Han, Yanfeng Zhuang, Zhihong Zhang, Lin Guo, Wanming Wang
This study is aimed at exploring the effect of stress stimulation on the proliferation and differentiation of fibrochondrocytes in entheses mediated via the Indian hedgehog (Ihh)/parathyroid hormone-related protein (PTHrP) signaling pathway. Differential stress stimulation on fibrochondrocytes in entheses was imposed. Gene expression and protein levels of signaling molecules including collagen type I (Col I), Col II, Col X, Ihh, and PTHrP in the cytoplasm of fibrochondrocytes were detected. Ihh signal blocking group was set up using Ihh signaling pathway-specific blocking agent cyclopamine...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27994095/diffusion-weighted-imaging-is-a-sensitive-biomarker-of-response-to-biologic-therapy-in-enthesitis-related-arthritis
#9
Timothy J P Bray, Kanimozhi Vendhan, Nicola Ambrose, David Atkinson, Shonit Punwani, Corinne Fisher, Debajit Sen, Yiannis Ioannou, Margaret A Hall-Craggs
OBJECTIVE: The aim was to evaluate diffusion-weighted imaging (DWI) as a tool for measuring treatment response in adolescents with enthesitis-related arthropathy (ERA). METHODS: Twenty-two adolescents with ERA underwent routine MRI and DWI before and after TNF inhibitor therapy. Each patient's images were visually scored by two radiologists using the Spondyloarthritis Research Consortium of Canada system, and sacroiliac joint apparent diffusion coefficient (ADC) and normalized ADC (nADC) were measured for each patient...
December 19, 2016: Rheumatology
https://www.readbyqxmd.com/read/27981814/evidence-based-algorithm-for-diagnosis-and-assessment-in-psoriatic-arthritis-results-by-italian-delphi-in-psoriatic-arthritis-idea
#10
G Lapadula, A Marchesoni, F Salaffi, R Ramonda, C Salvarani, L Punzi, L Costa, F Caso, D Simone, G Baiocchi, C Scioscia, M Di Carlo, R Scarpa, G Ferraccioli
Psoriatic arthritis (PsA) is a chronic inflammatory disease involving skin, peripheral joints, entheses, and axial skeleton. The disease is frequently associated with extrarticular manifestations (EAMs) and comorbidities. In order to create a protocol for PsA diagnosis and global assessment of patients with an algorithm based on anamnestic, clinical, laboratory and imaging procedures, we established a DElphi study on a national scale, named Italian DElphi in psoriatic Arthritis (IDEA). After a literature search, a Delphi poll, involving 52 rheumatologists, was performed...
December 16, 2016: Reumatismo
https://www.readbyqxmd.com/read/27932277/detection-of-subclinical-ultrasound-enthesopathy-and-nail-disease-in-patients-at-risk-of-psoriatic-arthritis
#11
Marie Acquitter, Laurent Misery, Alain Saraux, Luc Bressollette, Sandrine Jousse-Joulin
OBJECTIVES: To detect subclinical entheses and nail abnormalities using gray-scale (GS) and power Doppler ultrasonography (PDUS) between patients with nail psoriasis and those with inverse and scalp psoriasis. METHODS: In this prospective monocentric study, patients with nail, inverse and scalp psoriasis, without psoriatic arthritis or systemic treatment, were included. Clinical evaluation and ultrasonographic assessment of 14 entheses and 12 nails were done by a dermatologist (clinical assessment) and a rheumatologist (ultrasonographic assessment)...
December 5, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27931958/imaging-in-the-diagnosis-and-management-of-peripheral-psoriatic-arthritis-the-clinical-utility-of-magnetic-resonance-imaging-and-ultrasonography
#12
REVIEW
Mikkel Østergaard, Lihi Eder, Sara Nysom Christiansen, Gurjit S Kaeley
Psoriatic arthritis (PsA) is an inflammatory joint disease characterised by the presence of arthritis and often enthesitis and/or spondylitis in patients with psoriasis. However, it presents a wide range of disease manifestations in various patterns. Imaging is an important part of management of PsA, and is used for multiple reasons including establishing/confirming a diagnosis of inflammatory joint disease, determining the extent of disease, monitoring activity and damage, assessing therapeutic efficacy, and identifying complications of disease or treatment, in the setting of clinical practice or clinical studies...
August 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27925474/fiber-development-and-matrix-production-in-tissue-engineered-menisci-using-bovine-mesenchymal-stem-cells-and-fibrochondrocytes
#13
Mary Clare McCorry, Lawrence J Bonassar
Mesenchymal stem cells (MSCs) have been investigated with promising results for meniscus healing and tissue engineering. While MSCs are known to contribute to ECM production, less is known about how MSCs produce and align large organized fibers for application to tissue engineering the meniscus. The goal of this study was to investigate the capability of MSCs to produce and organize extracellular matrix molecules compared to meniscal fibrochondrocytes (FCCs). Bovine FCCs and MSCs were encapsulated in an anatomically accurate collagen meniscus using mono-culture and co-culture of each cell type...
December 7, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27900348/implementation-of-musculoskeletal-ultrasonography-in-detection-of-early-juvenile-idiopathic-arthritis
#14
Ayman F Darwish, Faten M Ismael, Abdou Ell-Laban, Ahmed Hamed, Moustafa Abdel Kader, Ashraf Osman
AIM: To determine whether early clinical, laboratory and musculoskeletal ultrasound (MSUS) characteristics can be used as early detectors of juvenile idiopathic arthritis. PATIENTS AND METHODS: Forty (40) patients with juvenile idiopathic arthritis (JIA) diagnosed according to the ILAR criteria [1] and 20 healthy control children. All patients were subjected to the following assessment at base line and at follow up after 6 months: Clinical evaluation, MSUS examination and laboratory evaluation...
2016: European Journal of Radiology Open
https://www.readbyqxmd.com/read/27900299/assessment-of-enthesitis-in-patients-with-psoriatic-arthritis-using-clinical-examination-and-ultrasound
#15
Salome Kristensen, Jeppe Hagstrup Christensen, Erik Berg Schmidt, Jens Lykkegaard Olesen, Martin Berg Johansen, Kristian Bakke Arvesen, Annette Schlemmer
BACKGROUND: Enthesitis is a major feature of psoriatic arthritis. However, clinical assessment of enthesitis is known to lack accuracy and have poor interobserver reliability. OBJECTIVE: To determine effect of training on clinical assessment of enthesitis and to compare ultrasonography with clinical examination for the detection of entheseal abnormalities. METHODS: 20 rheumatologists performed repeated assessment of enthesitis in patients with established psoriatic arthritis before and after a 2-hour training session in standardised enthesitis count according to Leeds Enthesitis Index (LEI) and Spondyloarthritis Research Consortium of Canada Enthesitis Index (SPARCC)...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27882408/-evidence-based-recommendations-on-diagnostics-and-therapy-of-axial-spondyloarthritis-s3-guidelines-of-the-german-society-of-rheumatology-dgrh-in-cooperation-with-the-association-of-the-scientific-medical-societies-in-germany-awmf
#16
REVIEW
U Kiltz, M Rudwaleit, J Sieper, J Braun
The clinical course of axial spondyloarthritis (SpA) is variable and characterized by chronic back pain and extraspinal manifestations, such as asymmetrical arthritis, dactylitis and enthesitis. Extra-articular manifestations in the eyes (anterior uveitis), skin (psoriasis) and intestines (chronic inflammatory bowel disease) are also frequent manifestations in patients with SpA. Due to the heterogeneity of disease manifestations and the partial concentration on structural alterations in the sacroiliac joints visible in X‑ray images, the diagnosis is often delayed for many years...
November 23, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27861762/gut-microbiome-in-children-with-enthesitis-related-arthritis-in-a-developing-country-and-the-effect-of-probiotic-administration
#17
A Aggarwal, A N Sarangi, P Gaur, A Shukla, Rakesh Aggarwal
In Asia, enthesitis-related arthritis (ERA) is the most frequent category of juvenile idiopathic arthritis. ERA has a strong association with human leucocyte antigen (HLA)-B27 and subclinical gut inflammation. In an HLA-B27 transgenic rat model, the presence of Bacteroides bacteria in the gut appears to cause spondyloarthropathy (SpA). Thus, we studied gut microbiota in children with ERA. Stool specimens from 33 patients with ERA and 14 age-matched healthy controls were studied; none had any gastrointestinal symptom, or had received a drug known to affect gut motility or microbiota in the preceding 6 weeks...
November 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27860304/nail-involvement-can-predict-enthesopathy-in-patients-with-psoriasis
#18
Maria Castellanos-González, Beatriz Esther Joven, Julio Sánchez, Eva María Andrés-Esteban, Francisco Vanaclocha-Sebastián, Pablo Ortiz Romero, Raquel Rivera Díaz
BACKGROUND: Although subclinical enthesopathy is a well-established diagnostic criterion for psoriatic arthritis (PsA), it is frequently overlooked, as many patients are asymptomatic. The possibility of finding a clinical clue predicting enthesopathy would help clinicians establish an early diagnosis of PsA. MATERIAL AND METHODS: A prospective single-center study of a total of 90 patients with psoriasis was conducted to assess the presence of entheseal abnormalities as detected by ultrasound, and to determine any correlation with nail involvement...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27856661/differential-mechanisms-of-de-regulated-bone-formation-in-rheumatoid-arthritis-and-spondyloarthritis
#19
REVIEW
Steven R Goldring
The inflammatory arthropathies share in common their tendency to produce marked alterations in skeletal remodelling and architecture. This review will focus on RA and the seronegative spondyloarthopathies (SpA), which share common features with respect to their tendency to produce localized bone destruction at sites of articular and peri-articular inflammation. However, there are significant differences in the skeletal pathology in these conditions, which include the unique involvement of the axial skeleton and the presence of inflammation in the extra-articular entheses in SpA...
December 2016: Rheumatology
https://www.readbyqxmd.com/read/27856658/new-targets-in-psoriatic-arthritis
#20
REVIEW
Juergen Braun
PsA is an immune-mediated chronic inflammatory disease that affects both skin and joints; it is a heterogeneous disease characterized by synovitis, enthesitis, dactylitis and spondylitis. The impact on patients and the burden of disease are substantial. For assessment of the disease, patient-reported outcomes are increasingly important. Conventional therapy consists of NSAIDs, local and systemic CSs, and synthetic and biological DMARDs. While MTX, LEF, SSZ and CYC are the synthetic drugs mainly used, TNF-α blocking agents have represented the majority of biologics used in the last decade (infliximab, etanercept, adalimumab, certolizumab and golimumab)...
December 2016: Rheumatology
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