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https://www.readbyqxmd.com/read/29238865/construct-validity-and-sensitivity-to-change-of-belgrade-ultrasound-enthesitis-score-in-patients-with-spondyloarthritis-a-pilot-study
#1
Sanja Milutinovic, Goran Radunovic, Kristina Veljkovic, Maja Zlatanovic, Nemanja Damjanov
The objective of this study was to determine the construct validity and sensitivity to change of Belgrade Ultrasound Enthesitis Score (BUSES) in spondyloarthritis patients. Seventy-six spondyloarthritis patients with enthesitis were included in this pilot, prospective, double-blinded ultrasound study. Thirty-four patients received biological and forty-two patients received non-biological therapy. BUSES was determined at the beginning, after 1, 3, and 6 months. Spearman's correlation coefficient was calculated between BUSES and baseline characteristics...
December 13, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29237324/systemic-lupus-erythematosus-arthropathy-the-sonographic-perspective
#2
A Di Matteo, R De Angelis, E Cipolletta, E Filippucci, W Grassi
Background Despite being promising, the use of ultrasound (US) in the assessment of musculoskeletal manifestations of systemic lupus erythematosus (SLE) is still limited. Literature on this topic is scarce and the spectrum and clinical relevance of US abnormalities has not yet been outlined. With this paper, we aim to explore the panel of joint and tendon US findings in a group of SLE patients. Methods Twenty-five consecutive SLE patients, with current or medical history of musculoskeletal symptoms, were studied...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29233691/enthesopathy-in-rheumatoid-arthritis-and-spondyloarthritis-an-ultrasound-study
#3
Esther Ebstein, Baptiste Coustet, Vanina Masson-Behar, Marine Forien, Elisabeth Palazzo, Philippe Dieudé, Sébastien Ottaviani
OBJECTIVE: We aimed to compare the prevalence of enthesopathy seen on ultrasonography (US) in spondyloarthritis (SpA) and rheumatoid arthritis (RA) and compared it to healthy controls. METHODS: All included patients with RA (2010 ACR/EULAR criteria) and SpA (ASAS criteria) and healthy controls underwent clinical and US evaluation of enthesis at seven sites (quadriceps, proximal and distal patellar, Achilles and triceps tendons, plantar aponeurosis and lateral epicondyle enthesis)...
December 9, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29227428/asymmetric-oligoarthritis-with-enthesitis-associated-with-acute-mumps-virus-infection
#4
Koji Yokoyama, Akira Yoshida
No abstract text is available yet for this article.
January 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29225916/prediction-and-benefits-of-minimal-disease-activity-in-patients-with-psoriatic-arthritis-and-active-skin-disease-in-the-adept-trial
#5
Philip J Mease, Arthur Kavanaugh, Laura C Coates, Iain B McInnes, Maja Hojnik, Ying Zhang, Jaclyn K Anderson, Alexander P Dorr, Dafna D Gladman
Objectives: To determine the proportion of patients with psoriatic arthritis in the Adalimumab Effectiveness in Psoriatic Arthritis trial achieving minimal disease activity (MDA) and its individual components at 1 or more visits over 144 weeks, identify baseline predictors of MDA achievement, and evaluate the association of MDA status with independent quality of life (QoL)-related patient-reported outcomes (PROs). Methods: Univariate and multivariate analyses were used to identify the baseline characteristics that predicted achievement of MDA at individual time points (weeks 12 through 144) or sustained MDA (achievement of MDA at 2 consecutive time points 12 weeks apart)...
2017: RMD Open
https://www.readbyqxmd.com/read/29217947/coexistence-of-peripheral-spondyloarthritis-and-familial-adenomatous-polyposis-a-rare-case-report-with-treatment-contradictions-and-review-of-the-literature
#6
Berna Urkmez, Muge Kepekci, Sevde Ozer Posul, Aylin Rezvani
Background: The coexistence of familial adenomatous polyposis and spondyloarthritis is rarely defined in literature. The primary aim of this presentation is to report a development of peripheral arthritis in 3 years following colon surgery with the diagnosis of familial adenomatous polyposis (FAP). The secondary aim is to discuss the challenge of in treatment of refractory arthritis, which needs to be treated with biologics. However, it is not yet known well about their safety on patients who have risks for cancer development...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29204760/the-detection-of-arthritis-in-inflammatory-bowel-diseases-detail-questionnaire-development-and-preliminary-testing-of-a-new-tool-to-screen-patients-with-inflammatory-bowel-disease-for-the-presence-of-spondyloarthritis
#7
Marco Di Carlo, Michele Maria Luchetti, Devis Benfaremo, Eleonora Di Donato, Piergiorgio Mosca, Stefania Maltoni, Antonio Benedetti, Armando Gabrielli, Walter Grassi, Fausto Salaffi
To develop and to test in a preliminary way a new self-administered screening tool, called DETection of Arthritis in Inflammatory boweL diseases (DETAIL) questionnaire, in patients suffering from inflammatory bowel disease (IBD) not previously diagnosed as having a spondyloarthritis (SpA). DETAIL questionnaire was realized through the interrogation of 95 experts. They were asked to rate the importance of a list of items, derived from a review of the referral models of SpA, to detect the SpA manifestations in IBD patients...
December 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29202587/focussing-on-the-foot-in-psoriatic-arthritis-pathology-and-management-options
#8
Aimie Patience, Philip S Helliwell, Heidi J Siddle
Psoriatic arthritis (PsA) is a heterogeneous chronic inflammatory arthritis characterised by a range of musculoskeletal conditions including enthesitis, dactylitis and synovitis as well as skin and nail manifestations. The foot is a complex mixture of tissues, all of which can be involved in this disease and is frequently the presenting feature. Areas covered: In this under-researched area, articles were reviewed from the authors' publications as well as from other known authors. This review will discuss how PsA affects the foot and ankle with a particular focus on synovitis, tenosynovitis, enthesitis, dactylitis, bone erosion and psoriatic skin and nail disease...
December 5, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29202535/-the-safety-and-efficacy-of-golimumab-in-treatment-of-25-patients-with-active-ankylosing-spondylitis
#9
H Ma, F Sun, Y M Zhang, H Zhang, J Zhu, X H Deng, J L Zhang, F Huang
Objective: To evaluate the efficacy and safety of golimumab in patients with active ankylosing spondylitis (AS). Methods: This was a randomized, double-blind, placebo-controlled trial. The subjects were randomized to receive either golimumab 50mg subcutaneously or placebo every 4 weeks. Patients in both groups received golimumab 50mg from week 24 to week 48. The primary endpoint was the proportion of at least 20% improvement in the Assessment of Spondyloarthritis International Society (ASAS20) at week 14. The secondary endpoints included at least 40% improvement in the Assessment of Spondyloarthritis International Society (ASAS40), ASAS partial-remission, Bath AS functional index, Bath AS disease activity index, Bath AS metrology index, enthesitis index and Jenkins sleep evaluation questionnaire...
December 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29197921/enthesitis-of-the-hands-in-psoriatic-arthritis-an-ultrasonographic-perspective
#10
Alen Zabotti, Luca Idolazzi, Alberto Batticciotto, Orazio De Lucia, Carlo Alberto Scirè, Ilaria Tinazzi, Annamaria Iagnocco
Psoriatic arthritis is a systemic inflammatory disease in which enthesitis and dactylitis are two of the main hallmarks of the disease. In the last years, ultrasonography is increasingly playing a key role in the diagnosis of psoriatic arthritis and ultrasonography of the entheses, particularly of the lower limbs, is commonly used to assess patients with that disease. New advancements in ultrasound equipment using high frequencies probes allowed us also to identify and characterize the involvementof the entheses of the hand in psoriatic arthritis, confirming the results of the experimental models of the disease and the theory of the sinovial-entheseal complex, even in small joints...
November 29, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/29187009/ixekizumab-an-anti-il-17a-monoclonal-antibody-for-the-treatment-of-psoriatic-arthritis
#11
Eric Toussirot
Psoriatic arthritis (PsA) is an inflammatory rheumatic disease that manifests itself with synovitis, dactylitis, enthesitis and also axial involvement. Interleukin-17A has been identified as a master cytokine in the inflammatory response and pathogenesis of PsA and spondyloarthritis in general. Ixekizumab is a new humanized monoclonal antibody that blocks the biological activity of IL-17A. This biological agent has previously demonstrated a high level of efficacy in psoriasis. Areas covered: This review discusses the basic immunology of the IL-17 cytokine family, the contribution of IL-17A to the immunopathogenesis of PsA, the clinical trials that evaluated ixekizumab in patients with PsA (SPIRIT program) and the safety of this agent...
November 29, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29185959/recommendations-for-the-use-of-biologics-and-other-novel-drugs-in-the-treatment-of-psoriatic-arthritis-2017-update-from-the-italian-society-of-rheumatology
#12
Antonio Marchesoni, Ignazio Olivieri, Carlo Salvarani, Nicolò Pipitone, Salvatore D'Angelo, Alessandro Mathieu, Alberto Cauli, Leonardo Punzi, Roberta Ramonda, Raffaele Scarpa, Mara Maccarone, Ennio Lubrano
OBJECTIVES: To update the 2011 Italian Society of Rheumatology (SIR) recommendations for the use of biologics and other novel agents in the treatment of psoriatic arthritis (PsA). METHODS: To create this new set of recommendations, the SIR "Spondyloartritis and Psoriatic Arthritis study group - A. Spadaro" went through the following steps: literature search, identification of the items of interests for each of the four previously identified clinical domains of PsA and the different treatment phases, achievement of the consensus on all topics, and generation of the recommendations...
November 28, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29185286/lessons-learned-from-imaging-on-enthesitis-in-psoriatic-arthritis
#13
REVIEW
Abdulla Watad, Iris Eshed, Dennis McGonagle
Enthesitis is a term that refers to inflammation at tendon, ligament, or joint capsule insertions. The entheses are increasinlgly considered to be the primary site of joint inflammation in the spondyloarthropathies including psoriatic arthritis (PsA). Great advances have occurred in the understanding of enthesopathy, which has resulted in a better understanding of the etiopathogenesis of PsA. Enthesitis is difficult to assess on both clinical examination and on imaging because of the overlap in features between mechanical, degenerative, and inflammatory pathologies...
November 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29185281/ankylosing-spondylitis-and-neck-pain-mri-evidence-for-joint-and-entheses-inflammation-at-the-craniocervial-junction
#14
Cheri Korb, Abid Awisat, Doron Rimar, Itzhak Rosner, Arsen Schpigelman, Daniela Militianu, Gleb Slobodin
BACKGROUND: Magnetic resonance imaging (MRI), which has recently become the leading imaging modality in the study of ankylosing spondylitis (AS), has not been evaluated in the assessment of disease-specific changes at the craniocervical junction (CCJ) in patients with AS. OBJECTIVES: To describe the spectrum of active inflammatory lesions at the CCJ using MRI in a cohort of patients with AS and neck pain. METHODS: The study included 18 patients with AS presenting with neck pain and a control group of 9 fibromyalgia patients matched for age and levels of neck pain...
November 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29185278/styloid-process-elongation-on-cervical-spine-computed-tomography-is-associated-with-the-enthesopathy-related-diseases-of-ankylosing-spondylitis-and-diffuse-idiopathic-skeletal-hyperostosis
#15
Talia Levy, Salim Bader, Kay-Geert Hermann, Gal Yaniv, Gahl Grinberg, Oshry Mozes, Merav Lidar, Iris Eshed
BACKGROUND: Enthesopathy may lead to calcification of the stylohyoid ligament and can cause elongation of the styloid process (SP). OBJECTIVES: To evaluate whether SP elongation is associated with two common enthesitis-related diseases: ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH). METHODS: Cervical spine computed tomography (CT) examinations of patients with DISH (n=64, Resnick criteria), AS (n=24, New York criteria) and a controls (no radiological signs of DISH or AS, n=54) were retrospectively evaluated...
November 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29173658/prolotherapy-for-the-thoracolumbar-myofascial-system
#16
REVIEW
Bradley D Fullerton
Prolotherapy has focused on entheses as a key source of chronic low back pain, even without clear diagnosis of enthesopathy. Treatment has traditionally been guided by anatomic knowledge and careful palpation. This article integrates ultrasonographic diagnosis of fascial injury with examination findings taught in traditional prolotherapy technique. Thoracolumbar fascial anatomy and biotensegrity theory are used to explain patient presentation and response to treatment at these pathologic findings. Detailed case reports provide proof of concept for the 60-year history of prolotherapy in the treatment of chronic low back pain...
February 2018: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29158573/enthesitis-from-pathophysiology-to-treatment
#17
REVIEW
Georg Schett, Rik J Lories, Maria-Antonietta D'Agostino, Dirk Elewaut, Bruce Kirkham, Enrique R Soriano, Dennis McGonagle
Entheses are the insertion sites of tendons and ligaments to the bone surface and are essential structures for locomotion. Inflammation of the entheses (enthesitis) is a key feature of psoriatic arthritis and spondyloarthritis. To date, our conceptual understanding of enthesitis remains limited. This Review provides an insight into the pathophysiology of enthesitis, addressing the role of biomechanics, prostaglandin E2-mediated vasodilation and the activation of innate immune cells in the initiation phase of enthesitis, as well as the role of entheseal IL-23-responsive cells that augment inflammation by producing pro-inflammatory mediators such as IL-17A, IL-22 and TNF...
November 21, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29151015/diffuse-idiopathic-skeletal-hyperostosis-dish-as-a-cause-of-failure-following-distal-clavicle-excision-a-case-report-and-review-of-the-literature
#18
John Begly, Vineet Tyagi, Eric Strauss
Diffuse idiopathic skeletal hyperostosis (DISH) is common spinal condition characterized by increased calcification and ossification of ligaments and entheses, typically in the anterior aspect of the spine. However, extraspinal manifestations of the disease can occur and depending on the degree and location of involvement, may become symptomatic. We present the case of a 63-year-old male with a history of DISH, who failed initial open distal clavicle excision due to the postoperative development of heterotopic bone bridging across the acromioclavicular joint...
December 2017: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/29142035/the-sex-influence-on-response-to-tumor-necrosis-factor-%C3%AE-inhibitors-and-remission-in-axial-spondyloarthritis
#19
Ennio Lubrano, Fabio Massimo Perrotta, Maria Manara, Salvatore D'Angelo, Olga Addimanda, Roberta Ramonda, Leonardo Punzi, Ignazio Olivieri, Carlo Salvarani, Antonio Marchesoni
OBJECTIVE: The aim of this study was to evaluate the influence of sex on response to treatment and disease remission in patients with axial spondyloarthritis (axSpA). METHODS: In this retrospective multicenter study, patients with axSpA, according to the Assessment of Spondyloarthritis international Society (ASAS) criteria for axSpA, and treated with adalimumab, etanercept, golimumab, or infliximab, were studied. We compared clinical characteristics, patient-reported outcomes, disease activity, function, and response to treatment in male and female patients with this disease...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29142032/minimal-disease-activity-as-a-treatment-target-in-psoriatic-arthritis-a-review-of-the-literature
#20
Laure Gossec, Dennis McGonagle, Tatiana Korotaeva, Ennio Lubrano, Eugenio de Miguel, Mikkel Østergaard, Frank Behrens
As in other inflammatory rheumatic diseases, the objective of psoriatic arthritis (PsA) treatment is the achievement of a defined target. Recent recommendations propose aiming for remission or low disease activity; however, a consensual definition of remission is lacking. A state of minimal disease activity (MDA) has been established and is defined by low activity assessed by tender/swollen joint counts, tender entheseal points, Psoriasis Area and Severity Index or body surface area, patient pain and global activity visual analog scale, and functional evaluation by Health Assessment Questionnaire...
November 15, 2017: Journal of Rheumatology
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