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https://www.readbyqxmd.com/read/29156848/nomograms-for-prognostic-factors-of-spinal-giant-cell-tumor-combining-traditional-clinical-characteristics-with-inflammatory-biomarkers-after-gross-total-resection
#1
Jialin Li, Bo Li, Pingting Zhou, Jian Zhao, Zhipeng Wu, Xinghai Yang, Haifeng Wei, Tianrui Chen, Jianru Xiao
Giant cell tumor (GCT) of bone is a common primary bone tumor, which exhibits local aggressiveness and recurrent potential, especially for the spinal lesion. Increasing evidence indicates that inflammation plays a vital role in tumorigenesis and progression. The prognostic value of inflammatory biomarkers in GCT has not been established. A retrospective analysis was conducted in patients with spinal GCT in Changzheng Hospital Orthopedic Oncological Center (CHOOC) between January 2005 and October 2015 and 129 patients were identified eligible...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156829/mdm4-genetic-variants-predict-hpv16-positive-tumors-of-patients-with-squamous-cell-carcinoma-of-the-oropharynx
#2
Zhongming Lu, Hua Zhang, Ye Tao, Xiangping Li, Guojun Li
The increasing incidence of squamous cell carcinoma of the oropharynx (SCCOP) is majorly attributed to the human papillomavirus (HPV) infection. Both HPV and MDM4 play a critical role in inhibition of p53 activity, thus affecting HPV tumor status of SCCOP. Three polymorphisms in MDM4 were genotyped from blood genomic DNA samples and HPV16 status in tumor specimens was examined. Odds ratio (OR) and 95% confidence intervals (CIs) in univariate and multivariable logistic regression models were calculated for the associations between these polymorphisms and HPV16 status...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156782/trends-in-neoadjuvant-chemotherapy-use-and-oncological-outcomes-for-muscle-invasive-bladder-cancer-in-japan-a-multicenter-study
#3
Go Anan, Shingo Hatakeyama, Naoki Fujita, Hiromichi Iwamura, Toshikazu Tanaka, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Makoto Sato, Chikara Ohyama
Objective: Despite benefits of neoadjuvant chemotherapy (NAC), the adoption of guideline recommendations for NAC use in patients with muscle-invasive bladder cancer (MIBC) has been slow. We aimed to evaluate temporal trends in NAC use and oncological outcomes in a representative cohort of patients with MIBC. Methods: We included 532 patients from 4 hospitals who underwent radical cystectomy (RC) for ≥ cT2 MIBC in 1996-2017. We retrospectively evaluated temporal changes in NAC use and progression-free and overall survival...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156780/baicalein-inhibits-progression-of-osteosarcoma-cells-through-inactivation-of-the-wnt-%C3%AE-catenin-signaling-pathway
#4
Guo Dai, Di Zheng, Qianliang Wang, Jian Yang, Gaiwei Liu, Qi Song, Xiangran Sun, Chunjie Tao, Qingzhu Hu, Tian Gao, Ling Yu, Weichun Guo
Osteosarcoma is a very common type of malignant bone tumor in children and young adults and aberrant activation of Wnt/β-catenin signaling pathway has been discovered in osteosarcoma. The traditional Chinese medicine baicalein was proved to have anti-proliferative and anti-metastatic properties in osteosarcoma, but the mechanism remained poorly understood. In the present study, we assessed the effects of baicalein on osteosarcoma and detected the potential molecular mechanism. We found that baicalein significantly suppressed the proliferation of osteosarcoma cells in a concentration- and time-dependent manner...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156773/association-of-acyp2-and-mphosph6-genetic-polymorphisms-with-the-risk-of-hepatocellular-carcinoma-in-chronic-hepatitis-b-virus-carriers
#5
Yingai Zhang, Shunlan Wang, Xiaohong Wen, Shufang Zhang, Yijun Yang
Hepatocellular carcinoma (HCC) is the dominant histologic type of primary liver cancer, and hepatitis B virus (HBV) infection is one of the major causes of HCC in the chronic HBV. Our study was investigated the association between the polymorphisms of ACYP2 and MPHOSPH6 genes and the risk of HCC induced by HBV infection. A total of 490 subjects were divided into two groups: 248 HBV patients with HCC (Case group), and 242 HBV patients without HCC (Control group). Unconditional logistic regression analysis was used to evaluate the association...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156768/clinical-significance-of-pre-surgical-serum-lipid-levels-in-patients-with-glioblastoma
#6
Ruofei Liang, Junhong Li, Mao Li, Yuan Yang, Xiang Wang, Qing Mao, Yanhui Liu
Accumulating evidence demonstrates that pre-surgical serum lipid levels are linked to the clinical outcome of different types of human malignant tumors, but few studies have explored the prognostic value of these easily accessible parameters in glioblastoma. The aim of the current study was to validate the association between pre-surgical serum lipid levels and the clinical outcome of patients with glioblastoma. The pre-surgical serum lipid levels (triglycerides, total cholesterol, high-density lipoprotein [HDL] cholesterol, and low-density lipoprotein [LDL] cholesterol) of 125 patients with glioblastoma, who underwent surgery between January 2015 and May 2016, were retrospectively evaluated...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156759/smoking-and-gender-modify-the-effect-of-twist-on-patient-survival-in-head-and-neck-squamous-carcinoma
#7
Yun Zhu, Wenjuan Zhang, Ping Wang
Purpose: TWIST is a critical factor for predicting prognosis in several human cancers. Here, we study the prognostic significance of TWIST1 and TWIST2 in Head and Neck squamous cell carcinoma (HNSCC) as well as interactions of TWISTs with both gender and smoking in patient survival. Methods: upper quartile normalized RNA-seq V2 RSEM values of TWIST1 and TWIST2 expressions were retrieved from a TCGA HNSCC dataset. Kaplan-Meier survival curves were used to assess the associations of TWIST1 and TWIST2 with patient survival, and multivariate Cox proportional hazards regression models were used to estimate the hazards ratios (HRs) and their 95% confidence intervals (CIs)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156751/identification-of-potential-tissue-specific-cancer-biomarkers-and-development-of-cancer-versus-normal-genomic-classifiers
#8
Akram Mohammed, Greyson Biegert, Jiri Adamec, Tomáš Helikar
Machine learning techniques for cancer prediction and biomarker discovery can hasten cancer detection and significantly improve prognosis. Recent "OMICS" studies which include a variety of cancer and normal tissue samples along with machine learning approaches have the potential to further accelerate such discovery. To demonstrate this potential, 2,175 gene expression samples from nine tissue types were obtained to identify gene sets whose expression is characteristic of each cancer class. Using random forests classification and ten-fold cross-validation, we developed nine single-tissue classifiers, two multi-tissue cancer-versus-normal classifiers, and one multi-tissue normal classifier...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156742/prmda-personalized-recommendation-based-mirna-disease-association-prediction
#9
Zhu-Hong You, Luo-Pin Wang, Xing Chen, Shanwen Zhang, Xiao-Fang Li, Gui-Ying Yan, Zheng-Wei Li
Recently, researchers have been increasingly focusing on microRNAs (miRNAs) with accumulating evidence indicating that miRNAs serve as a vital role in various biological processes and dysfunctions of miRNAs are closely related with human complex diseases. Predicting potential associations between miRNAs and diseases is attached considerable significance in the domains of biology, medicine, and bioinformatics. In this study, we developed a computational model of Personalized Recommendation-based MiRNA-Disease Association prediction (PRMDA) to predict potential related miRNA for all diseases by implementing personalized recommendation-based algorithm based on integrated similarity for diseases and miRNAs...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156714/investigation-of-factors-affecting-the-efficacy-of-3c23k-a-human-monoclonal-antibody-targeting-misiir
#10
Sarah E Gill, Qing Zhang, Gary L Keeney, William A Cliby, S John Weroha
MISIIR is a potential target for ovarian cancer (OC) therapy due to its tissue-specific pattern of expression. 3C23K is a novel therapeutic monoclonal anti-MISIIR antibody designed to recruit effector cells and promote cell death through ADCC (antibody dependent cell-mediated cytotoxicity). Our objective was to determine the tolerability and efficacy of 3C23K in OC patient-derived xenografts (PDX) and to identify factors affecting efficacy. Quantitative RT-PCR, immunohistochemistry (IHC), and flow cytometry were used to categorize MISIIR expression in established PDX models derived from primary OC patients...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156498/first-things-first-risk-model-performance-metrics-should-reflect-the-clinical-application
#11
Kathleen F Kerr, Holly Janes
Developing new measures of risk model performance is an active line of research, often motivated by the conventional wisdom that area under the ROC curve is an 'insensitive' measure of the additional predictive capacity offered by new biomarkers. Without endorsing area under the ROC curve, we argue that this charge is not substantiated. Three articles in this issue discuss alternative metrics of risk model performance: NRI(p) (two-category net reclassification index at the event rate), integrated discrimination index, and R-squared statistics...
December 10, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29156480/-frailty-prevalence-in-the-resident-population-of-germany-70%C3%A2-%C3%A2-79-years-of-age-a-population-based-approach
#12
Judith Fuchs, Markus Busch, Christa Scheidt-Nave
In all countries life expectancy is rising, and many older persons spend a longer period in good health. Nevertheless, frailty is present in older people and can be considered as a risk factor for limitations. The "German Health Interview and Examination Survey for Adults" (DEGS1) 2008 - 2011 comprised interviews, examinations and tests. Data on 1110 community-dwelling people aged 70 to 79 years participating in DEGS1 with full records on frailty were analysed. Physical frailty was defined as exhaustion (SF-36 item), low grip strength, slowness (Timed Up-and-Go test > 15 seconds or unable to perform) and low physical activity (no sports or exertion)...
November 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29156441/modeling-spray-drift-and-runoff-related-inputs-of-pesticides-to-receiving-water
#13
Xuyang Zhang, Yuzhou Luo, Kean S Goh
Pesticides move to surface water via various pathways including surface runoff, spray drift and subsurface flow. Little is known about the relative contributions of surface runoff and spray drift in agricultural watersheds. This study develops a modeling framework to address the contribution of spray drift to the total loadings of pesticides in receiving water bodies. The modeling framework consists of a GIS module for identifying drift potential, the AgDRIFT model for simulating spray drift, and the Soil and Water Assessment Tool (SWAT) for simulating various hydrological and landscape processes including surface runoff and transport of pesticides...
November 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29156429/kinetics-of-biogas-production-and-chemical-oxygen-demand-removal-from-compost-leachate-in-an-anaerobic-migrating-blanket-reactor
#14
Aliasghar Ebrahimi, Hassan Hashemi, Hadi Eslami, Reza Ali Fallahzadeh, Rasoul Khosravi, Roohollah Askari, Esmail Ghahramani
In this study, laboratory anaerobic migrating blanket reactor (AMBR) with four units was used to reduce and remove COD leachate of composting process; it was also used to determine the kinetic coefficients of COD removal and biogas and methane gas production in several different OLRs. The maximum concentration of organic matter entering the reactor was 100,000 mg/L and the reactor was under operation for 319 days. The results showed that the COD removal efficiency of AMBR in all concentrations of substrate entering the reactor was above 80%...
November 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29156412/a-system-level-mathematical-model-of-basal-ganglia-motor-circuit-for-kinematic-planning-of-arm-movements
#15
Armin Salimi-Badr, Mohammad Mehdi Ebadzadeh, Christian Darlot
In this paper, a novel system-level mathematical model of the Basal Ganglia (BG) for kinematic planning, is proposed. An arm composed of several segments presents a geometric redundancy. Thus, selecting one trajectory among an infinite number of possible ones requires overcoming redundancy, according to some kinds of optimization. Solving this optimization is assumed to be the function of BG in planning. In the proposed model, first, a mathematical solution of kinematic planning is proposed for movements of a redundant arm in a plane, based on minimizing energy consumption...
November 10, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29156382/discovery-of-selective-dengue-virus-inhibitors-using-combination-of-molecular-fingerprint-based-virtual-screening-protocols-structure-based-pharmacophore-model-development-molecular-dynamics-simulations-and-in-vitro-studies
#16
Shaher Bano Mirza, Regina Ching Hua Lee, Justin Jang Hann Chu, Ramin Ekhteiari Salmas, Thomas Mavromoustakos, Serdar Durdagi
Dengue virus is a major issue of tropical and sub-tropical regions. The proliferation of virus results in immense number of deaths each year because of unavailability of on-shelf drugs. This issue necessitates the design of novel anti-Dengue drugs. The protease enzyme pathway is the critical target for drug design due to its significance in the replication, survival and other cellular activities of Dengue virus. Keeping in mind the worsening situation regarding Dengue virus, approximately eighteen million drug-like compounds from the ZINC small molecule database have been screened against Nonstructural Protein 3 (NS3) previously by our group...
October 24, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29156295/components-of-schizophrenia-liability-are-not-uniformly-associated-with-stress-sensitivity-resilience-and-coping
#17
Christian Ruzibiza, Rebecca E Grattan, Rebekah Eder, Richard J Linscott
Stress sensitization is a candidate final common pathway for the development of schizophrenia. In other psychopathologies, resilience attenuates the stressor-outcome relationships. Therefore, we sought to determine whether resilience moderates the association between stress sensitivity and schizophrenia liability. Undergraduates (n = 230) self-reported cognitive-perceptual, interpersonal, and disorganisation attributes of schizophrenia liability as well as ratings of sensitivity to stress, resilience, and dispositional coping behaviour...
November 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29156285/modelling-spatial-and-temporal-variations-of-annual-suspended-sediment-yields-from-small-agricultural-catchments
#18
A Rymszewicz, M Bruen, J J O'Sullivan, J N Turner, D M Lawler, J R Harrington, E Conroy, M Kelly-Quinn
Estimates of sediment yield are important for ecological and geomorphological assessment of fluvial systems and for assessment of soil erosion within a catchment. Many regulatory frameworks, such as the Convention for the Protection of the Marine Environment of the North-East Atlantic, derived from the Oslo and Paris Commissions (OSPAR) require reporting of annual sediment fluxes. While they may be measured in large rivers, sediment flux is rarely measured in smaller rivers. Measurements of sediment transport at a national scale can be also challenging and therefore, sediment yield models are often utilised by water resource managers for the predictions of sediment yields in the ungauged catchments...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156267/using-dynamic-flux-chambers-to-estimate-the-natural-attenuation-rates-in-the-subsurface-at-petroleum-contaminated-sites
#19
Iason Verginelli, Roberto Pecoraro, Renato Baciocchi
In this work, we introduce a screening method for the evaluation of the natural attenuation rates in the subsurface at sites contaminated by petroleum hydrocarbons. The method is based on the combination of the data obtained from standard source characterization with dynamic flux chambers measurements. The natural attenuation rates are calculated as difference between the flux of contaminants estimated with a non-reactive diffusive model starting from the concentrations of the contaminants detected in the source (soil and/or groundwater) and the effective emission rate of the contaminants measured using dynamic flux chambers installed at ground level...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29156257/surrounding-land-cover-types-as-predictors-of-palustrine-wetland-vegetation-quality-in-conterminous-usa
#20
Martin A Stapanian, Brian Gara, William Schumacher
The loss of wetland habitats and their often-unique biological communities is a major environmental concern. We examined vegetation data obtained from 380 wetlands sampled in a statistical survey of wetlands in the USA. Our goal was to identify which surrounding land cover types best predict two indices of vegetation quality in wetlands at the regional scale. We considered palustrine wetlands in four regions (Coastal Plains, North Central East, Interior Plains, and West) in which the dominant vegetation was emergent, forested, or scrub-shrub...
November 16, 2017: Science of the Total Environment
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