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https://www.readbyqxmd.com/read/29346908/mechanisms-of-self-organized-criticality-in-social-processes-of-knowledge-creation
#1
Bosiljka Tadić, Marija Mitrović Dankulov, Roderick Melnik
In online social dynamics, a robust scale invariance appears as a key feature of collaborative efforts that lead to new social value. The underlying empirical data thus offers a unique opportunity to study the origin of self-organized criticality (SOC) in social systems. In contrast to physical systems in the laboratory, various human attributes of the actors play an essential role in the process along with the contents (cognitive, emotional) of the communicated artifacts. As a prototypical example, we consider the social endeavor of knowledge creation via Questions and Answers (Q&A)...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29325489/creating-effective-biocontainment-facilities-and-maintenance-protocols-for-raising-specific-pathogen-free-severe-combined-immunodeficient-scid-pigs
#2
Ellis J Powell, Sara Charley, Adeline N Boettcher, Lisa Varley, Justin Brown, Martine Schroyen, Malavika K Adur, Susan Dekkers, Dean Isaacson, Mary Sauer, Joan Cunnick, N Matthew Ellinwood, Jason W Ross, Jack Cm Dekkers, Christopher K Tuggle
Severe combined immunodeficiency (SCID) is defined by the lack of an adaptive immune system. Mutations causing SCID are found naturally in humans, mice, horses, dogs, and recently in pigs, with the serendipitous discovery of the Iowa State University SCID pigs. As research models, SCID animals are naturally tolerant of xenotransplantation and offer valuable insight into research areas such as regenerative medicine, cancer therapy, as well as immune cell signaling mechanisms. Large-animal biomedical models, particularly pigs, are increasingly essential to advance the efficacy and safety of novel regenerative therapies on human disease...
January 1, 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29311050/detecting-novel-and-emerging-drug-terms-using-natural-language-processing-a-social-media-corpus-study
#3
Sean S Simpson, Nikki Adams, Claudia M Brugman, Thomas J Conners
BACKGROUND: With the rapid development of new psychoactive substances (NPS) and changes in the use of more traditional drugs, it is increasingly difficult for researchers and public health practitioners to keep up with emerging drugs and drug terms. Substance use surveys and diagnostic tools need to be able to ask about substances using the terms that drug users themselves are likely to be using. Analyses of social media may offer new ways for researchers to uncover and track changes in drug terms in near real time...
January 8, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29290754/effects-of-recent-energy-system-changes-on-co2-projections-for-the-united-states
#4
Carol S Lenox, Daniel H Loughlin
Recent projections of future United States carbon dioxide (CO2) emissions are considerably lower than projections made just a decade ago. A myriad of factors have contributed to lower forecasts, including reductions in end-use energy service demands, improvements in energy efficiency, and technological innovations. Policies that have encouraged these changes include renewable portfolio standards, corporate vehicle efficiency standards, smart growth initiatives, revisions to building codes, and air and climate regulations...
September 21, 2017: Clean Technologies and Environmental Policy
https://www.readbyqxmd.com/read/29289057/a-unifying-view-of-synchronization-for-data-assimilation-in-complex-nonlinear-networks
#5
Henry D I Abarbanel, Sasha Shirman, Daniel Breen, Nirag Kadakia, Daniel Rey, Eve Armstrong, Daniel Margoliash
Networks of nonlinear systems contain unknown parameters and dynamical degrees of freedom that may not be observable with existing instruments. From observable state variables, we want to estimate the connectivity of a model of such a network and determine the full state of the model at the termination of a temporal observation window during which measurements transfer information to a model of the network. The model state at the termination of a measurement window acts as an initial condition for predicting the future behavior of the network...
December 2017: Chaos
https://www.readbyqxmd.com/read/29277724/supersaturated-silica-lipid-hybrids-super-slh-an-improved-solid-state-lipid-based-oral-drug-delivery-system-with-enhanced-drug-loading
#6
Hayley B Schultz, Nicky Thomas, Shasha Rao, Clive A Prestidge
The method of supersaturation for achieving high drug loads in lipid-based formulations is under exploited and relatively unexplored, especially in the case of solid-state lipid-based formulations. Silica-lipid hybrids are solid-state lipid-based formulations designed for improving the oral delivery of poorly water-soluble drugs. However, their application to compounds of low potency and requiring large doses is limited by their low drug loading capacity. Here, an innovative technique to fabricate supersaturated silica-lipid hybrid formulations (super-SLH) has been established and the relationship between drug load and performance investigated...
December 22, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29276307/in-vitro-assessment-of-small-charged-pharmaceutical-aerosols-in-a-model-of-a-ventilated-neonate
#7
Landon Holbrook, Michael Hindle, P Worth Longest
Aerosolized medications may benefit infants receiving mechanical ventilation; however, the lung delivery efficiency of these aerosols is unacceptably low. In vitro experiments were conducted to evaluate aerosol delivery through conventional and modified ventilation systems to the end of a 3mm endotracheal tube (ETT) under steady state and realistic cyclic flow conditions. System modifications were employed to investigate the use of small charged particles and included streamlined components, a reduction in nebulizer liquid flow rate, synchronization with inspiration, and implementation of a previously designed low-flow induction charger (LF-IC), which was further modified in this study...
August 2017: Journal of Aerosol Science
https://www.readbyqxmd.com/read/29273612/interprofessional-care-collaboration-for-patients-with-heart-failure
#8
Amanda Boykin, Danielle Wright, Lydia Stevens, Lauren Gardner
PURPOSE: An innovative collaborative care model to improve transitions of care (TOC) for patients with heart failure (HF) is described. SUMMARY: As part of a broad effort by New Hanover Regional Medical Center (NHRMC) to reduce avoidable 30-day hospital readmissions and decrease associated healthcare costs through a team-centered, value-based approach to patient care, an interprofessional team was formed to help reduce hospital readmissions among discharged patients with HF...
January 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29248525/assessing-the-efficiency-of-wolbachia-driven-aedes-mosquito-suppression-by-delay-differential-equations
#9
Mugen Huang, Jiaowan Luo, Linchao Hu, Bo Zheng, Jianshe Yu
To suppress wild population of Aedes mosquitoes, the primary transmission vector of life-threatening diseases such as dengue, malaria, and Zika, an innovative strategy is to release male mosquitoes carrying the bacterium Wolbachia into natural areas to drive female sterility by cytoplasmic incompatibility. We develop a model of delay differential equations, incorporating the strong density restriction in the larval stage, to assess the delicate impact of life table parameters on suppression efficiency. Through mathematical analysis, we find the sufficient and necessary condition for global stability of the complete suppression state...
December 14, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29241437/the-swiss-mental-health-care-system
#10
Andres R Schneeberger, Bruce J Schwartz
The United States and Switzerland are among the world's wealthiest countries. Both are highly innovative and entrepreneurial, ranking high in global competitiveness and innovation and with similar liberal economies. This column highlights features of the health care system in Switzerland, a country with an exclusively private health insurance system, with federally mandated universal health insurance. Residents can choose from about 58 insurance companies. Switzerland regulates these companies and negotiates reimbursement rates...
December 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29239739/endophenotypes-a-conceptual-link-between-anorexia-nervosa-and-autism-spectrum-disorder
#11
Z C Zhou, D B McAdam, D R Donnelly
The paper, by translating the concept and the two models of endophenotype (EP), strengthens the hypothesis that there exists a linkage between anorexia nervosa (AN) and autism spectrum disorder (ASD). Specifically, the paper synthesizes empirical research that supported the idea that individuals with AN and individuals with ASD share similarities with respect to their neurocognitive EPs and temperament EPs. The paper then introduces an innovative structure to emphasize the subtle difference between neurocognitive EPs and temperament EPs in relation to AN and ASD...
November 24, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29236537/social-work-s-role-in-medicaid-reform-a-qualitative-study
#12
Sara S Bachman, Madeline Wachman, Leticia Manning, Alexander M Cohen, Robert W Seifert, David K Jones, Therese Fitzgerald, Rachel Nuzum, Patricia Riley
OBJECTIVES: To critically analyze social work's role in Medicaid reform. METHODS: We conducted semistructured interviews with 46 stakeholders from 10 US states that use a range of Medicaid reform approaches. We identified participants using snowball and purposive sampling. We gathered data in 2016 and analyzed them using qualitative methods. RESULTS: Multiple themes emerged: (1) social work participates in Medicaid reform through clinical practice, including care coordination and case management; (2) there is a gap between social work's practice-level and systems-level involvement in Medicaid innovations; (3) factors hindering social work's involvement in systems-level practice include lack of visibility, insufficient clarity on social work's role and impact, and too few resources within professional organizations; and (4) social workers need more training in health transformation payment models and policy...
December 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29233529/innovating-patient-care-delivery-dsrip-s-interrupted-time-series-analysis-paradigm
#13
Amrita G Shenoy, Charles E Begley, Lee Revere, Stephen H Linder, Stephen P Daiger
INTRODUCTION: Adoption of Medicaid Section 1115 waiver is one of the many ways of innovating healthcare delivery system. The Delivery System Reform Incentive Payment (DSRIP) pool, one of the two funding pools of the waiver has four categories viz. infrastructure development, program innovation and redesign, quality improvement reporting and lastly, bringing about population health improvement. BACKGROUND: A metric of the fourth category, preventable hospitalization (PH) rate was analyzed in the context of eight conditions for two time periods, pre-reporting years (2010-2012) and post-reporting years (2013-2015) for two hospital cohorts, DSRIP participating and non-participating hospitals...
December 7, 2017: Healthcare
https://www.readbyqxmd.com/read/29229805/nonlinear-water-waves-introduction-and-overview
#14
A Constantin
For more than two centuries progress in the study of water waves proved to be interdependent with innovative and deep developments in theoretical and experimental directions of investigation. In recent years, considerable progress has been achieved towards the understanding of waves of large amplitude. Within this setting one cannot rely on linear theory as nonlinearity becomes an essential feature. Various analytic methods have been developed and adapted to come to terms with the challenges encountered in settings where approximations (such as those provided by linear or weakly nonlinear theory) are ineffective...
January 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29224642/drug-induced-cardiac-abnormalities-in-premature-infants-and-neonates
#15
REVIEW
Luana Pesco-Koplowitz, Gary Gintant, Robert Ward, Dominique Heon, Muriel Saulnier, Jeff Heilbraun
The Cardiac Safety Research Consortium (CSRC) is a transparent, public-private partnership that was established in 2005 as a Critical Path Program and formalized in 2006 under a Memorandum of Understanding between the United States Food and Drug Administration and Duke University. Our continuing goal is to advance paradigms for more efficient regulatory science related to the cardiovascular safety of new therapeutics, both in the United States and globally, particularly where such safety questions add burden to innovative research and development...
January 2018: American Heart Journal
https://www.readbyqxmd.com/read/29218496/testing-the-association-between-traditional-and-novel-indicators-of-county-level-structural-racism-and-birth-outcomes-among-black-and-white-women
#16
Brittany D Chambers, Jennifer Toller Erausquin, Amanda E Tanner, Tracy R Nichols, Shelly Brown-Jeffy
Despite decreases in infants born premature and at low birth weight in the United States (U.S.), racial disparities between Black and White women continue. In response, the purpose of this analysis was to examine associations between both traditional and novel indicators of county-level structural racism and birth outcomes among Black and White women. We merged individual-level data from the California Birth Statistical Master Files 2009-2013 with county-level data from the United States (U.S.) Census American Community Survey...
December 7, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29216255/forecasting-success-via-early-adoptions-analysis-a-data-driven-study
#17
Giulio Rossetti, Letizia Milli, Fosca Giannotti, Dino Pedreschi
Innovations are continuously launched over markets, such as new products over the retail market or new artists over the music scene. Some innovations become a success; others don't. Forecasting which innovations will succeed at the beginning of their lifecycle is hard. In this paper, we provide a data-driven, large-scale account of the existence of a special niche among early adopters, individuals that consistently tend to adopt successful innovations before they reach success: we will call them Hit-Savvy. Hit-Savvy can be discovered in very different markets and retain over time their ability to anticipate the success of innovations...
2017: PloS One
https://www.readbyqxmd.com/read/29203616/validation-and-diagnostic-accuracy-of-predictive-curves-for-age-associated-longitudinal-cognitive-decline-in-older-adults
#18
Patrick J Bernier, Christian Gourdeau, Pierre-Hugues Carmichael, Jean-Pierre Beauchemin, René Verreault, Rémi W Bouchard, Edeltraut Kröger, Robert Laforce
BACKGROUND: The Mini-Mental State Examination continues to be used frequently to screen for cognitive impairment in older adults, but it remains unclear how to interpret changes in its score over time to distinguish age-associated cognitive decline from an early degenerative process. We aimed to generate cognitive charts for use in clinical practice for longitudinal evaluation of age-associated cognitive decline. METHODS: We used data from the Canadian Study of Health and Aging from 7569 participants aged 65 years or older who completed a Mini-Mental State Examination at baseline, and at 5 and 10 years later to develop a linear regression model for the Mini-Mental State Examination score as a function of age and education...
December 4, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29203543/a-novel-mechanism-behind-the-immunopathogenesis-of-vulvovaginal-candidiasis-neutrophil-anergy
#19
Junko Yano, Brian M Peters, Mairi C Noverr, Paul L Fidel
For over three decades, investigators have studied the pathogenesis of vulvovaginal candidiasis (VVC) and recurrent VVC (RVVC) through clinical studies and animal models. While there was considerable consensus that susceptibility was not associated with any apparent deficiencies in adaptive immunity, protective immune mechanisms and the role of innate immunity remained elusive. It was not until an innovative live challenge design was conducted in women that a fuller understanding of the natural history of infection/disease was achieved...
December 4, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29195023/computational-modeling-of-single-cell-mechanics-and-cytoskeletal-mechanobiology
#20
REVIEW
Vijay Rajagopal, William R Holmes, Peter Vee Sin Lee
Cellular cytoskeletal mechanics plays a major role in many aspects of human health from organ development to wound healing, tissue homeostasis and cancer metastasis. We summarize the state-of-the-art techniques for mathematically modeling cellular stiffness and mechanics and the cytoskeletal components and factors that regulate them. We highlight key experiments that have assisted model parameterization and compare the advantages of different models that have been used to recapitulate these experiments. An overview of feed-forward mechanisms from signaling to cytoskeleton remodeling is provided, followed by a discussion of the rapidly growing niche of encapsulating feedback mechanisms from cytoskeletal and cell mechanics to signaling...
November 30, 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
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