keyword
MENU ▼
Read by QxMD icon Read
search

state innovation models

keyword
https://www.readbyqxmd.com/read/28921829/vegetation-demographics-in-earth-system-models-a-review-of-progress-and-priorities
#1
Rosie A Fisher, Charles D Koven, William R L Anderegg, Bradley O Christoffersen, Michael C Dietze, Caroline Farrior, Jennifer A Holm, George Hurtt, Ryan G Knox, Peter J Lawrence, Jeremy W Lichststein, Marcos Longo, Ashley M Matheny, David Medvigy, Helene C Muller-Landau, Thomas L Powell, Shawn P Serbin, Hisashi Sato, Jacquelyn Shuman, Benjamin Smith, Anna T Trugman, Toni Viskari, Hans Verbeeck, Ensheng Weng, Chonggang Xu, Xiangtao Xu, Tao Zhang, Paul Moorcroft
Numerous current efforts seek to improve the representation of ecosystem ecology and vegetation demographic processes within Earth System Models (ESMs). These developments are widely viewed as an important step in developing greater realism in predictions of future ecosystem states and fluxes. Increased realism, however, leads to increased model complexity, with new features raising a suite of ecological questions that require empirical constraints. Here, we review the developments that permit the representation of plant demographics in ESMs, and identify issues raised by these developments that highlight important gaps in ecological understanding...
September 18, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28912960/influence-of-disease-activity-on-ra-treatment-choices-in-countries-with-restricted-access-to-expensive-innovative-drugs-a-discrete-choice-experiment-among-rheumatologists
#2
Monika Hifinger, Mickael Hiligsmann, Sofia Ramiro, Verity Watson, Florian Berghea, Márta Péntek, Andrew Keat, Johan L Severens, Bruno Fautrel, Annelies Boonen
OBJECTIVE: To assess the influence of disease activity of patients with rheumatoid arthritis on treatment choices of rheumatologists in countries with restricted access to expensive, innovative drugs. METHODS: Rheumatologists from Hungary, Romania and UK were invited to complete two consecutive discrete choice experiments with hypothetical drug treatments for two different patient profiles: high and moderate disease activity. Rheumatologists were asked to choose repeatedly between two unlabelled treatment options that differed in five attributes: efficacy (expected improvement and achieved disease activity state), safety (probability of serious adverse events), patient's preference (level of agreement), total medication costs and cost-effectiveness...
2017: RMD Open
https://www.readbyqxmd.com/read/28894833/ethmoidectomy-combined-with-superior-meatus-enlargement-increases-olfactory-airflow
#3
Hironobu Nishijima, Kenji Kondo, Tsutomu Nomura, Tatsuya Yamasoba
OBJECTIVES: The relationship between a particular surgical technique in endoscopic sinus surgery (ESS) and airflow changes in the post-operative olfactory region has not been assessed. The present study aimed to compare olfactory airflow after ESS between conventional ethmoidectomy and ethmoidectomy with superior meatus enlargement, using virtual ESS and computational fluid dynamics (CFD) analysis. STUDY DESIGN: Prospective computational study. MATERIALS AND METHODS: Nasal computed tomography images of four adult subjects were used to generate models of the nasal airway...
August 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28892776/clinical-trial-simulations-in-paediatric-oncology-a%C3%A2-feasibility-study-from-the-innovative-therapies-for-children-with-cancer-consortium
#4
Julie M Janssen, C Michel Zwaan, Jan H M Schellens, Jos H Beijnen, Alwin D R Huitema
INTRODUCTION: Paediatric dose-finding studies are challenging to perform due to ethical reasons, the limited number of available patients and restricted number of blood samples. In certain cases, the adult pharmacokinetic (PK) exposure can be used as target for dose finding in paediatrics. The aim of this study was to investigate the performance of a paediatric phase I dose-finding clinical trial in silico. METHODS: Using an adult pharmacokinetic model, clinical trial simulations were performed to determine the power of a proposed clinical trial design...
September 8, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28890604/monitoring-of-batch-industrial-crystallization-with-growth-nucleation-and-agglomeration-part-2-structure-design-for-state-estimation-with-secondary-measurements
#5
Marcella Porru, Leyla Özkan
This work investigates the design of alternative monitoring tools based on state estimators for industrial crystallization systems with nucleation, growth, and agglomeration kinetics. The estimation problem is regarded as a structure design problem where the estimation model and the set of innovated states have to be chosen; the estimator is driven by the available measurements of secondary variables. On the basis of Robust Exponential estimability arguments, it is found that the concentration is distinguishable with temperature and solid fraction measurements while the crystal size distribution (CSD) is not...
August 30, 2017: Industrial & Engineering Chemistry Research
https://www.readbyqxmd.com/read/28886057/principal-component-based-weighted-indices-and-a-framework-to-evaluate-indices-results-from-the-medical-expenditure-panel-survey-1996-to-2011
#6
Yi-Sheng Chao, Chao-Jung Wu
Producing indices composed of multiple input variables has been embedded in some data processing and analytical methods. We aim to test the feasibility of creating data-driven indices by aggregating input variables according to principal component analysis (PCA) loadings. To validate the significance of both the theory-based and data-driven indices, we propose principles to review innovative indices. We generated weighted indices with the variables obtained in the first years of the two-year panels in the Medical Expenditure Panel Survey initiated between 1996 and 2011...
2017: PloS One
https://www.readbyqxmd.com/read/28878063/mitochondrial-phylogenomics-of-hemiptera-reveals-adaptive-innovations-driving-the-diversification-of-true-bugs
#7
Hu Li, John M Leavengood, Eric G Chapman, Daniel Burkhardt, Fan Song, Pei Jiang, Jinpeng Liu, Xuguo Zhou, Wanzhi Cai
Hemiptera, the largest non-holometabolous order of insects, represents approximately 7% of metazoan diversity. With extraordinary life histories and highly specialized morphological adaptations, hemipterans have exploited diverse habitats and food sources through approximately 300 Myr of evolution. To elucidate the phylogeny and evolutionary history of Hemiptera, we carried out the most comprehensive mitogenomics analysis on the richest taxon sampling to date covering all the suborders and infraorders, including 34 newly sequenced and 94 published mitogenomes...
September 13, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28841550/scalable-joint-models-for-reliable-uncertainty-aware-event-prediction
#8
Hossein Soleimani, James Hensman, Suchi Saria
Missing data and noisy observations pose significant challenges for reliably predicting events from irregularly sampled multivariate time series (longitudinal) data. Imputation methods, which are typically used for completing the data prior to event prediction, lack a principled mechanism to account for the uncertainty due to missingness. Alternatively, state-of-the-art joint modeling techniques can be used for jointly modeling the longitudinal and event data and compute event probabilities conditioned on the longitudinal observations...
August 21, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28835615/logic-programming-reveals-alteration-of-key-transcription-factors-in-multiple-myeloma
#9
Bertrand Miannay, Stéphane Minvielle, Olivier Roux, Pierre Drouin, Hervé Avet-Loiseau, Catherine Guérin-Charbonnel, Wilfried Gouraud, Michel Attal, Thierry Facon, Nikhil C Munshi, Philippe Moreau, Loïc Campion, Florence Magrangeas, Carito Guziolowski
Innovative approaches combining regulatory networks (RN) and genomic data are needed to extract biological information for a better understanding of diseases, such as cancer, by improving the identification of entities and thereby leading to potential new therapeutic avenues. In this study, we confronted an automatically generated RN with gene expression profiles (GEP) from a cohort of multiple myeloma (MM) patients and normal individuals using global reasoning on the RN causality to identify key-nodes. We modeled each patient by his or her GEP, the RN and the possible automatically detected repairs needed to establish a coherent flow of the information that explains the logic of the GEP...
August 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28833854/new-methods-for-modelling-eq-5d-5l-value-sets-an-application-to-english-data
#10
Yan Feng, Nancy J Devlin, Koonal K Shah, Brendan Mulhern, Ben van Hout
Value sets for the EQ-5D-5L are required to facilitate its use in estimating quality-adjusted life years. An international protocol has been developed to guide the collection of stated preference data for this purpose and has been used to generate EQ-5D-5L valuation data for England. The aim of this paper is report the innovative methods used for modelling those data to obtain a value set. Nine hundred and ninety-six members of the English general public completed time trade-off (TTO) and discrete choice experiment (DCE) tasks...
August 18, 2017: Health Economics
https://www.readbyqxmd.com/read/28831111/maskless-x-ray-writing-of-electrical-devices-on-a-superconducting-oxide-with-nanometer-resolution-and-online-process-monitoring
#11
Lorenzo Mino, Valentina Bonino, Angelo Agostino, Carmelo Prestipino, Elisa Borfecchia, Carlo Lamberti, Lorenza Operti, Matteo Fretto, Natascia De Leo, Marco Truccato
X-ray nanofabrication has so far been usually limited to mask methods involving photoresist impression and subsequent etching. Herein we show that an innovative maskless X-ray nanopatterning approach allows writing electrical devices with nanometer feature size. In particular we fabricated a Josephson device on a Bi2Sr2CaCu2O8+δ (Bi-2212) superconducting oxide micro-crystal by drawing two single lines of only 50 nm in width using a 17.4 keV synchrotron nano-beam. A precise control of the fabrication process was achieved by monitoring in situ the variations of the device electrical resistance during X-ray irradiation, thus finely tuning the irradiation time to drive the material into a non-superconducting state only in the irradiated regions, without significantly perturbing the crystal structure...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818857/modeling-inborn-errors-of-hepatic-metabolism-using-induced-pluripotent-stem-cells
#12
REVIEW
Behshad Pournasr, Stephen A Duncan
Inborn errors of hepatic metabolism are because of deficiencies commonly within a single enzyme as a consequence of heritable mutations in the genome. Individually such diseases are rare, but collectively they are common. Advances in genome-wide association studies and DNA sequencing have helped researchers identify the underlying genetic basis of such diseases. Unfortunately, cellular and animal models that accurately recapitulate these inborn errors of hepatic metabolism in the laboratory have been lacking...
August 17, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28813635/standardization-and-scaling-of-a-community-based-palliative-care-model
#13
Janet Bull, Arif H Kamal, Matthew Harker, Donald H Taylor, Lindsay Bonsignore, John Morris, Lisa Massie, Parampal Singh Bhullar, Mary Howell, Mark Hendrix, Deeana Bennett, Amy Abernethy
BACKGROUND: Although limited, the descriptions of Community-Based Palliative Care (CBPC) demonstrates variability in team structures, eligibility, and standardization across care settings. OBJECTIVE: In 2014, Four Seasons Compassion for Life, a nonprofit hospice and palliative care (PC) organization in Western North Carolina (WNC), was awarded a Centers for Medicare and Medicaid Services Health Care Innovation (CMMI) Award to expand upon their existing innovative model to implement, evaluate, and demonstrate CBPC in the United States...
August 16, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28812961/community-managed-services-for-persons-with-intellectual-disability-andhra-pradesh-experience
#14
Jayanthi Narayan, Raja Pratapkumar, Sudhakara P Reddy
In resource poor settings innovative and bottom-up approaches are required to provide services to people with with disabilities. In this context, the present paper explains a community-based model of manpower development and coordination of services for people with intellectual disabilities in unified state of Andhra Pradesh in India. Women with disabilities from the village were identified, and those willing to be trained to work as community resource persons (CRPs) were selected and given hands-on training in a phased manner...
September 2017: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/28806908/changing-the-default-for-tobacco-cessation-treatment-in-an-inpatient-setting-study-protocol-of-a-randomized-controlled-trial
#15
Babalola Faseru, Edward F Ellerbeck, Delwyn Catley, Byron J Gajewski, Taneisha S Scheuermann, Theresa I Shireman, Laura M Mussulman, Niaman Nazir, Terry Bush, Kimber P Richter
BACKGROUND: Most health care providers do not treat tobacco dependence routinely. This may in part be due to the treatment "default." Current treatment guidelines recommend that providers (1) ask patients if they are willing to quit and (2) provide cessation-focused medications and counseling only to smokers who state that they are willing to quit. The default is that patients have to "opt in" to receive cessation assistance: providers ask smokers if they are willing to quit, and only offer medications and cessation support to those who say "yes...
August 14, 2017: Trials
https://www.readbyqxmd.com/read/28803081/building-an-outpatient-kidney-palliative-care-clinical-program
#16
Jennifer S Scherer, Rebecca Wright, Caroline S Blaum, Stephen P Wall
CONTEXT: A diagnosis of advanced chronic kidney disease (CKD), or end stage renal disease (ESRD) represents a significant life change for patients and families. Individuals often experience high symptom burden, decreased quality of life, increased health care utilization, and end-of-life care discordant with their preferences. Early integration of palliative care with standard nephrology practice in the outpatient setting has the potential to improve quality of life through provision of expert symptom management, emotional support, and facilitation of advance care planning that honors the individual's values and goals...
August 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28802377/an-innovative-approach-to-improve-ear-nose-and-throat-surgical-access-for-remote-living-cape-york-indigenous-children
#17
Susan P Jacups, Denise Newman, Deborah Dean, Ann Richards, Kate M McConnon
INTRODUCTION: On a background of high rates of severe otitis media (OM) with associated hearing loss, children from the Torres Strait and Cape York region requiring ear, nose and throat (ENT) surgery, faced waiting times exceeding three years. After numerous clinical safety incidents were raised, indicating a failure of the current system to deliver appropriate care, the governing Hospital and Health service opted to deliver surgical care through an alternate process. ENT surgeries were performed on 16 consented children from two remote locations via the private health care system, funded by a health provider partnership...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28800496/goal-commitment-predicts-treatment-outcome-for-adolescents-with-alcohol-use-disorder
#18
Yifrah Kaminer, Christine McCauley Ohannessian, James R McKay, Rebecca H Burke, Kaitlin Flannery
OBJECTIVE: Commitment to change is an innovative potential mediator and mechanism of behavior change (MOBC) that has not been examined in adolescents with substance use disorders (SUD). The Adolescent Substance Abuse Goal Commitment (ASAGC) questionnaire is a reliable and valid 2-scale measure developed to assess the adolescent's commitment to either abstinence or harm reduction (HR) that includes consumption reduction as a stated treatment goal. The objective of this study was to examine the ASAGC's ability to predict alcohol use treatment outcome...
July 31, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28796134/innovation-in-academic-progression-progress-of-the-new-mexico-nursing-education-consortium-model
#19
Jenny Landen, Diane Evans-Prior, Becky Dakin, Judy Liesveld
AIM: The Institute of Medicine (IOM) challenged nursing education programs to increase the proportion of nurses with a baccalaureate degree in nursing to 80 percent by 2020. BACKGROUND: All 18 state-funded prelicensure nursing programs in New Mexico joined forces to create the New Mexico Nursing Education Consortium (NMNEC). METHOD: NMNEC is a model of collaboration with a statewide common curriculum that provides seamless transferability for students between schools while offering the BSN on community college campuses...
September 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28795174/tissue-chips-innovative-tools-for-drug-development-and-disease-modeling
#20
REVIEW
L A Low, D A Tagle
The high rate of failure during drug development is well-known, however recent advances in tissue engineering and microfabrication have contributed to the development of microphysiological systems (MPS), or 'organs-on-chips' that recapitulate the function of human organs. These 'tissue chips' could be utilized for drug screening and safety testing to potentially transform the early stages of the drug development process. They can also be used to model disease states, providing new tools for the understanding of disease mechanisms and pathologies, and assessing effectiveness of new therapies...
September 12, 2017: Lab on a Chip
keyword
keyword
32666
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"