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https://www.readbyqxmd.com/read/29152988/value-and-innovation-of-direct-acting-antivirals-long-term-health-outcomes-of-the-strategic-plan-for-the-management-of-hepatitis-c-in-spain
#1
Juan Turnes, Raquel Domínguez-Hernández, Miguel Ángel Casado
OBJECTIVE: To assess the long-term healthcare costs and health outcome in association with the access to new direct-acting antivirals (DAAs), during the first year of the National Strategic Plan for Chronic Hepatitis C (SPCHC) in patients with chronic hepatitis C (CHC) in Spain. METHODS: A decision tree and a lifetime Markov model were developed to simulate the natural history, morbidity, and mortality of a cohort of 51,900 patients with CHC before (pre-DAA strategy) and after (post-DAA strategy) access to DAA, following SPCHC approval...
November 20, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29143411/spontaneous-neural-activity-differences-in-posttraumatic-stress-disorder-a-quantitative-resting-state-meta-analysis-and-fmri-validation
#2
Seth G Disner, Craig A Marquardt, Bryon A Mueller, Philip C Burton, Scott R Sponheim
Identifying the pathophysiology of posttraumatic stress disorder (PTSD) is a critical step toward reducing its debilitating impact. Spontaneous neural activity, measured at rest using various neuroimaging techniques (e.g., regional homogeneity [ReHo], amplitude of low frequency fluctuations [ALFF]), can provide insight about baseline neurobiological factors influencing sensory, cognitive, or behavioral processes associated with PTSD. The present study used activation likelihood estimation (ALE) to conduct the largest-to-date quantitative meta-analysis of spontaneous neural activity in PTSD, including 457 PTSD cases, 292 trauma-exposed controls (TECs), and 293 non-traumatized controls (NTCs) across 22 published studies...
November 15, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29141015/nematocytes-discovery-and-characterization-of-a-novel-anculeate-hemocyte-in-drosophila-falleni-and-drosophila-phalerata
#3
Julianna Bozler, Balint Z Kacsoh, Giovanni Bosco
Immune challenges, such as parasitism, can be so pervasive and deleterious that they constitute an existential threat to a species' survival. In response to these ecological pressures, organisms have developed a wide array of novel behavioral, cellular, and molecular adaptations. Research into these immune defenses in model systems has resulted in a revolutionary understanding of evolution and functional biology. As the field has expanded beyond the limited number of model organisms our appreciation of evolutionary innovation and unique biology has widened as well...
2017: PloS One
https://www.readbyqxmd.com/read/29137503/global-lessons-in-frugal-innovation-to-improve-health-care-delivery-in-the-united-states
#4
Yasser Bhatti, Andrea Taylor, Matthew Harris, Hester Wadge, Erin Escobar, Matt Prime, Hannah Patel, Alexander W Carter, Greg Parston, Ara W Darzi, Krishna Udayakumar
In a 2015 global study of low-cost or frugal innovations, we identified five leading innovations that scaled successfully in their original contexts and that may provide insights for scaling such innovations in the United States. We describe common themes among these diverse innovations, critical factors for their translation to the United States to improve the efficiency and quality of health care, and lessons for the implementation and scaling of other innovations. We highlight promising trends in the United States that support adapting these innovations, including growing interest in moving care out of health care facilities and into community and home settings; the growth of alternative payment models and incentives to experiment with new approaches to population health and care delivery; and the increasing use of diverse health professionals, such as community health workers and advanced practice providers...
November 2017: Health Affairs
https://www.readbyqxmd.com/read/29119476/lessons-learned-implementation-of-pilot-universal-postpartum-nurse-home-visiting-program-massachusetts-2013-2016
#5
Katie Stetler, Christine Silva, Susan E Manning, Elizabeth M Harvey, Emma Posner, Becca Walmer, Karin Downs, Milton Kotelchuck
Purpose Home visiting programs for new families in the United States have traditionally served high-risk families. In contrast, universal home visiting models serve all families regardless of income, age, risk or other criteria. They offer an entry point into a system of care for children and families, with the potential to improve population health. This paper describes lessons learned from the first three years of implementing a universal home visiting model. Description Welcome Family is a universal home visiting program in Massachusetts that offers a one-time visit by a nurse to new mothers up to eight weeks postpartum...
November 8, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29118145/access-to-oral-health-care-a-national-crisis-and-call-for-reform
#6
Catherine H Bersell
Purpose: According to the report Healthy People 2020, oral health is integral to overall health and access to dental services is essential to promoting and maintaining good oral health. Yet, those who need dental care the most are often the least likely to receive it. The dental hygiene profession is poised to play a pivotal role in the resolution of oral health disparities. The purpose of this manuscript is to examine the critical issue of access to oral health care in the United States from various perspectives and consider potential implications for dental professionals and the oral health care system...
February 2017: Journal of Dental Hygiene: JDH
https://www.readbyqxmd.com/read/29114898/adapting-the-t0-t4-implementation-science-model-to-occupational-health-and-safety-in-agriculture-forestry-and-fishing-a-scoping-review
#7
REVIEW
Pamela J Tinc, Anne Gadomski, Julie A Sorensen, Lars Weinehall, Paul Jenkins, Kristina Lindvall
BACKGROUND: Despite much research to develop life-saving innovations for the agriculture, forestry, and fishing workforce, these populations continue to face the highest fatal and non-fatal injury rates in the United States, as many of these solutions are not fully adopted. METHODS: A scoping review was conducted to provide an overview of research to practice efforts in this field. The language used to describe these initiatives, the utility of the NIH T0-T4 model, and the progress along the research to practice continuum were examined...
November 8, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29113924/why-are-there-so-many-sedges-sumatroscirpeae-a-missing-piece-in-the-evolutionary-puzzle-of-the-giant-genus-carex-cyperaceae
#8
Étienne Léveillé-Bourret, Julian R Starr, Bruce A Ford
For over a century, the origins and mechanisms underlying the diversification of the enormous temperate genus Carex (>2100 species; Cariceae, Cyperaceae) have remained largely speculative. Characteristics such as its diverse ecology, varied biogeography, and intriguing cytology have made Carex a powerful model for studying plant evolution, but its uncertain sister-group relationships hinder its use in studies that depend on accurate ancestral state estimates and biogeographic inferences. To identify the sister to Carex, we estimated the phylogeny of all genera in the Cariceae-Dulichieae-Scirpeae clade (CDS) using three plastid and two nuclear ribosomal markers...
November 4, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29112683/targeting-de-novo-lipogenesis-as-a-novel-approach-in-anti-cancer-therapy
#9
Katharina Stoiber, Olga Nagło, Carla Pernpeintner, Siwei Zhang, Andreas Koeberle, Melanie Ulrich, Oliver Werz, Rolf Müller, Stefan Zahler, Theobald Lohmüller, Jochen Feldmann, Simone Braig
BACKGROUND: Although altered membrane physiology has been discussed within the context of cancer, targeting membrane characteristics by drugs being an attractive therapeutic strategy has received little attention so far. METHODS: Various acetyl-CoA carboxylase 1 (ACC1), and fatty acid synthase (FASN) inhibitors (like Soraphen A and Cerulenin) as well as genetic knockdown approaches were employed to study the effects of disturbed phospholipid composition on membrane properties and its functional impact on cancer progression...
November 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29102089/managing-multimorbidity-profiles-of-integrated-care-approaches-targeting-people-with-multiple-chronic-conditions-in-europe
#10
Mieke Rijken, Anneli Hujala, Ewout van Ginneken, Maria Gabriella Melchiorre, Peter Groenewegen, Franζois Schellevis
In response to the growing populations of people with multiple chronic diseases, new models of care are currently being developed in European countries to better meet the needs of these people. This paper aims to describe the occurrence and characteristics of various types of integrated care practices in European countries that target people with multimorbidity. Data were analysed from multimorbidity care practices participating in the Innovating care for people with multiple chronic conditions (ICARE4EU) project, covering all 28EU Member States, Iceland, Norway and Switzerland...
October 19, 2017: Health Policy
https://www.readbyqxmd.com/read/29097829/population-stress-a-spatiotemporal-analysis-of-population-change-and-land-development-at-the-county-level-in-the-contiguous-united-states-2001-2011
#11
Guangqing Chi, Hung Chak Ho
The past century has witnessed rapidly increasing population-land conflicts due to exponential population growth and its many consequences. Although the measures of population-land conflicts are many, there lacks a model that appropriately considers both the social and physical contexts of population-land conflicts. In this study we introduce the concept of population stress, which identifies areas with populations growing faster than the lands available for sustainable development. Specifically, population stress areas are identified by comparing population growth and land development as measured by land developability in the contiguous United States from 2001 to 2011...
January 2018: Land Use Policy
https://www.readbyqxmd.com/read/29094102/project-echo-a-telementoring-program-for-cervical-cancer-prevention-and-treatment-in-low-resource-settings
#12
Melissa S Lopez, Ellen S Baker, Andrea M Milbourne, Rose M Gowen, Ana M Rodriguez, Cesaltina Lorenzoni, Catherine Mwaba, Susan Citonje Msadabwe, José Humberto Tavares, Georgia Fontes-Cintra, Gustavo Zucca-Matthes, Donato Callegaro-Filho, Danielle Ramos-Martin, Icaro Thiago de Carvalho, Robson Coelho, Renato Moretti Marques, Thiago Chulam, Mila Pontremoli-Salcedo, Fernanda Nozar, Veronica Fiol, Mauricio Maza, Sanjeev Arora, Ernest T Hawk, Kathleen M Schmeler
Cervical cancer incidence and mortality rates are significantly higher in low- and middle-income countries compared with the United States and other developed countries. This disparity is caused by decreased access to screening, often coupled with low numbers of trained providers offering cancer prevention and treatment services. However, similar disparities are also found in underserved areas of the United States, such as the Texas-Mexico border, where cervical cancer mortality rates are 30% higher than in the rest of Texas...
October 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29084044/evolving-models-and-ongoing-challenges-for-hiv-pre-exposure-prophylaxis-implementation-in-the-united-states
#13
Kenneth H Mayer, Philip A Chan, Rupa Patel, Charlene A Flash, Douglas S Krakower
BACKGROUND: The use of pre-exposure prophylaxis (PrEP) for HIV prevention was approved by the FDA in 2012, but delivery to at risk persons has lagged. This critical review analyzes the current state of PrEP implementation in the US, by reviewing barriers, and innovative solutions, to enhanced PrEP access and uptake. SETTING: Clinical care settings, public health progrlams and community-based organizations (CBOs). METHODS: Critical review of recent peer-reviewed literature...
October 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29082710/-how-to-adapt-to-the-requirements-of-clinical-value-oriented-drug-innovation-for-pharmaceutical-research-in-application-process-of-new-traditional-chinese-medicine
#14
Fang Jin
On August 9, 2015, the State Council promulgated the "Opinions of the State Council on the reform of drug and medical device review and approval system" (Guofa 2015 No. 44), and established the "clinical value-oriented drug innovation" model to encourage the research and development of new drugs. Following that, China Food and Drug Administration (CFDA) promulgated the "Notice on several policies for drug registration review and approval" (2015 No. 230 ) on November 11, 2015, clearly specifying that CFDA would "implement one-time approval for clinical trials application of the new drugs, and no longer take a phased declaration, review and approval system; for the new drugs that apply for clinical trials, mainly review the scientific natureof the clinical protocols and the risk control of the new drugs to guarantee the safety of subjects"...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29061893/nascent-life-cycles-and-the-emergence-of-higher-level-individuality
#15
William C Ratcliff, Matthew Herron, Peter L Conlin, Eric Libby
Evolutionary transitions in individuality (ETIs) occur when formerly autonomous organisms evolve to become parts of a new, 'higher-level' organism. One of the first major hurdles that must be overcome during an ETI is the emergence of Darwinian evolvability in the higher-level entity (e.g. a multicellular group), and the loss of Darwinian autonomy in the lower-level units (e.g. individual cells). Here, we examine how simple higher-level life cycles are a key innovation during an ETI, allowing this transfer of fitness to occur 'for free'...
December 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29061155/building-capacity-for-medical-education-research-in-family-medicine-the-program-for-innovation-in-medical-education-pime
#16
Douglas Archibald, William Hogg, Jacques Lemelin, Simone Dahrouge, Mireille St Jean, François Boucher
BACKGROUND: Despite the apparent benefits to teaching, many faculty members are reluctant to participate in medical education research (MER) for a variety of reasons. In addition to the further demand on their time, physicians often lack the confidence to initiate MER projects and require more support in the form of funding, structure and guidance. These obstacles have contributed to a decline in physician participation in MER as well as to a perceived decay in its quality. As a countermeasure to encourage physicians to undertake research, the Department of Family Medicine at the University of Ottawa implemented a programme in which physicians receive the funding, coaching and support staff necessary to complete a 2-year research project...
October 23, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/29060005/rich-context-information-for-just-in-time-adaptive-intervention-promoting-physical-activity
#17
F Cruciani, C Nugent, I Cleland, P McCullagh
Sedentary lifestyle and inadequate levels of physical activity represent two serious health risk factors. Nevertheless, within developed countries, 60% of people aged over 60 are deemed to be sedentary. Consequently, interest in behavior change to promote physical activity is increasing. In particular, the role of emerging mobile apps to facilitate behavior change has shown promising results. Smart technologies can help in providing rich context information including an objective assessment of the level of physical activity and information on the emotional and physiological state of the person...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29053527/a-paradigm-shift-from-brick-and-mortar-full-time-nursing-faculty-off-campus
#18
Marlene Beck, Holly B Bradley, Linda L Cook, Joslin B Leasca, Tammy Lampley, JoAnne Gatti-Petito
The organizational structure for the Master of Science in Nursing's online program at Sacred Heart University offers a remarkably different innovative faculty model. Full-time, doctorally prepared faculty reside in several different states and teach online but are fully integrated and immersed in all aspects of the college of nursing. This untraditional model, which has proven to be successful over time using best practices for online education, is replicable and offers an innovative option for online learning...
October 20, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29050932/characteristics-of-patients-using-specialty-medications
#19
Taehwan Park, Scott K Griggs, Paul D Chung
BACKGROUND: Specialty medications include innovative drugs and biologic agents requiring special handling and close monitoring. Although specialty medications have been widely used for various chronic conditions, increased use of these medications has contributed a growing share of total health care expenditures. OBJECTIVE: The aim of this study was to examine patient characteristics related to specialty medication use. METHODS: Using Medical Expenditure Panel Survey (MEPS) data from 2000 through 2013, this study identified U...
October 14, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29048452/development-of-the-laboratory-prototype-cavypool-for-assessing-treatments-and-materials-for-swimming-pools
#20
F Valeriani, G Gianfranceschi, M Vitali, C Protano, V Romano Spica
BACKGROUND: Hygiene and surveillance in swimming pools are established by WHO Guidelines and national laws. Progress in water management and pool construction is revolutionizing the field, introducing new materials, systems, disinfection procedures or monitoring markers. Innovation advances challenge the upgrading of safety and quality in pools and the appropriate implementation of guidelines. STUDY DESIGN: In order to provide a device for laboratory test, a prototype was realized and applied to study and compare swimming pool materials and treatments...
November 2017: Annali di Igiene: Medicina Preventiva e di Comunità
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