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https://www.readbyqxmd.com/read/27911984/home-visitation-programs-an-untapped-opportunity-for-the-delivery-of-early-childhood-obesity-prevention
#1
S-J Salvy, K de la Haye, T Galama, M I Goran
BACKGROUND: Extant obesity efforts have had limited impact among low-income underserved children, in part because of limitations inherent to existing programs: (i) short duration and low intensity; (ii) late timing of implementation, when children are already overweight or obese; (iii) intervention delivery limiting their accessibility and sustainability; and (iv) failure to address barriers such as a lack of culturally competent services, poverty and housing instability, which interfere with healthy lifestyle changes...
December 2, 2016: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27908788/time-to-wake-up-studying-neurovascular-coupling-and-brain-wide-circuit-function-in-the-un-anesthetized-animal
#2
REVIEW
Yu-Rong Gao, Yuncong Ma, Qingguang Zhang, Aaron T Winder, Zhifeng Liang, Lilith Antinori, Patrick J Drew, Nanyin Zhang
Functional magnetic resonance imaging (fMRI) has allowed the noninvasive study of task-based and resting-state brain dynamics in humans by inferring neural activity from blood-oxygenation-level dependent (BOLD) signal changes. An accurate interpretation of the hemodynamic changes that underlie fMRI signals depends on the understanding of the quantitative relationship between changes in neural activity and changes in cerebral blood flow, oxygenation and volume. While there has been extensive study of neurovascular coupling in anesthetized animal models, anesthesia causes large disruptions of brain metabolism, neural responsiveness and cardiovascular function...
November 28, 2016: NeuroImage
https://www.readbyqxmd.com/read/27898829/gapit-version-2-an-enhanced-integrated-tool-for-genomic-association-and-prediction
#3
You Tang, Xiaolei Liu, Jiabo Wang, Meng Li, Qishan Wang, Feng Tian, Zhongbin Su, Yuchun Pan, Di Liu, Alexander E Lipka, Edward S Buckler, Zhiwu Zhang
Most human diseases and agriculturally important traits are complex. Dissecting their genetic architecture requires continued development of innovative and powerful statistical methods. Corresponding advances in computing tools are critical to efficiently use these statistical innovations and to enhance and accelerate biomedical and agricultural research and applications. The genome association and prediction integrated tool (GAPIT) was first released in 2012 and became widely used for genome-wide association studies (GWAS) and genomic prediction...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27895830/development-of-a-subspecialty-cardiology-curriculum-for-paediatric-registrars-in-malawi-implementation-of-a-long-distance-hybrid-model
#4
Laura Newberry, Neil Kennedy, Elizabeth A Greene
BACKGROUND: Malawi has a high burden of paediatric cardiac disease but a limited number of health providers familiar with these chronic diseases. Given the rising number of Malawian postgraduate paediatric trainees at the University of Malawi College of Medicine, we sought to remedy this lack of basic cardiology training with a long-distance, module-based curriculum that could be utilised independently, as needed, with on-site teaching. We also wished to evaluate the initial modules for utility and improvement in knowledge and confidence in each topic...
June 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27894307/regional-health-workforce-monitoring-as-governance-innovation-a-german-model-to-coordinate-sectoral-demand-skill-mix-and-mobility
#5
E Kuhlmann, O Lauxen, C Larsen
BACKGROUND: As health workforce policy is gaining momentum, data sources and monitoring systems have significantly improved in the European Union and internationally. Yet data remain poorly connected to policy-making and implementation and often do not adequately support integrated approaches. This brings the importance of governance and the need for innovation into play. CASE: The present case study introduces a regional health workforce monitor in the German Federal State of Rhineland-Palatinate and seeks to explore the capacity of monitoring to innovate health workforce governance...
November 28, 2016: Human Resources for Health
https://www.readbyqxmd.com/read/27894030/fatigue-in-hospital-nurses-supernurse-culture-is-a-barrier-to-addressing-problems-a-qualitative-interview-study
#6
Linsey M Steege, Jessica G Rainbow
BACKGROUND: Fatigue in hospital nurses is associated with decreased nurse satisfaction, increased turnover and negative patient outcomes. Addressing fatigue in nurses has been identified as a priority by many organizations worldwide in an effort to promote both a culture of patient safety and a healthy nursing workforce. OBJECTIVES: The overall aim of this study was to explore barriers and facilitators within the hospital nurse work system to nurse coping and fatigue...
November 21, 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/27893392/waterloo-exploration-database-new-challenges-for-image-quality-assessment-models
#7
Kede Ma, Zhengfang Duanmu, Qingbo Wu, Zhou Wang, Hongwei Yong, Hongliang Li, Lei Zhang
The great content diversity of real-world digital images poses a grand challenge to image quality assessment (IQA) models, which are traditionally designed and validated on a handful of commonly used IQA databases with very limited content variation. To test the generalization capability and to facilitate the wide usage of IQA techniques in realworld applications, we establish a large-scale database named the Waterloo Exploration Database, which in its current state contains 4; 744 pristine natural images and 94; 880 distorted images created from them...
November 22, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27891291/knowledge-about-hiv-in-a-community-sample-of-urban-african-americans-in-the-south
#8
H Klein, C E Sterk, K W Elifson
PURPOSE: Race and HIV are intertwined in complex ways. African Americans, particularly those residing in the southern United States, are at great risk for contracting and subsequently transmitting HIV. Research on the extent to which members of this population understand the risks associated with engaging in specific behaviors is limited. This paper examines HIV knowledge among at-risk adult African American men and women and the factors associated with levels of HIV knowledge. METHODS: Based on a conceptual model derived from Social Disorganization Theory and Syndemics Theory, interviews were conducted between 2009 and 2011...
October 2016: Journal of AIDS & Clinical Research
https://www.readbyqxmd.com/read/27890449/independent-evolution-of-genomic-characters-during-major-metazoan-transitions
#9
REVIEW
Oleg Simakov, Takeshi Kawashima
Metazoan evolution encompasses a vast evolutionary time scale spanning over 600 million years. Our ability to infer ancestral metazoan characters, both morphological and functional, is limited by our understanding of the nature and evolutionary dynamics of the underlying regulatory networks. Increasing coverage of metazoan genomes enables us to identify the evolutionary changes of the relevant genomic characters such as the loss or gain of coding sequences, gene duplications, micro- and macro-synteny, and non-coding element evolution in different lineages...
November 24, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27889643/multimodality-imaging-identifies-distinct-metabolic-profiles-in-vitro-and-in-vivo
#10
Marie-Aline Neveu, Géraldine De Preter, Valérie Marchand, Anne Bol, Jeffery R Brender, Keita Saito, Shun Kishimoto, Paolo E Porporato, Pierre Sonveaux, Vincent Grégoire, Olivier Feron, Bénédicte F Jordan, Murali C Krishna, Bernard Gallez
The study of alterations of tumor metabolism should allow the identification of new targets for innovative anticancer strategies. Metabolic alterations are generally established in vitro, and conclusions are often extrapolated to the in vivo situation without further tumor metabolic phenotyping. To highlight the key role of microenvironment on tumor metabolism, we studied the response of glycolytic and oxidative tumor models to metabolic modulations in vitro and in vivo. MDA-MB-231 and SiHa tumor models, characterized in vitro as glycolytic and oxidative, respectively, were studied...
November 24, 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27884729/rationale-and-design-of-the-coronary-artery-calcium-consortium-a-multicenter-cohort-study
#11
Michael J Blaha, Seamus P Whelton, Mahmoud Al Rifai, Zeina A Dardari, Leslee J Shaw, Mouaz H Al-Mallah, Kuni Matsushita, John A Rumberger, Daniel S Berman, Matthew J Budoff, Michael D Miedema, Khurram Nasir
BACKGROUND: Although coronary artery calcium (CAC) has been investigated for over two decades, there is very limited data on the association of CAC with cause of death. The CAC Consortium is a large ongoing multi-center observational cohort of individuals who underwent non-contrast cardiac-gated CAC testing and systematic, prospective, long-term follow-up for mortality with ascertainment of cause of death. METHODS: Four participating institutions from three states within the US (California, Minnesota, and Ohio) have contributed individual-level patient data to the CAC Consortium (spanning years 1991-2010)...
November 11, 2016: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/27873477/telemedically-supported-case-management-of-living-donor-renal-transplant-recipients-to-optimize-routine-evidence-based-aftercare-a-single-center-randomized-controlled-trial
#12
A Schmid, S Hils, A Kramer-Zucker, L Bogatyreva, D Hauschke, S De Geest, P Pisarski
Improving mid-term and long-term outcomes after solid organ transplantation is imperative, and requires both state-of-the-art transplant surgery and optimization of routine, evidence-based aftercare. This randomized, controlled trial assessed the effectiveness of standard aftercare versus telemedically-supported case management, an innovative aftercare model, in 46 living-donor renal transplant recipients during the first post-transplant year. The model includes three components: (a) chronic care case management initiated after discharge, (b) case management initiated in emerging acute care situations, and (c) a telemedically-equipped team comprising a transplant nurse case manager and two senior transplant physicians (nephrologist, surgeon)...
November 22, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27858406/molecular-imaging-of-neuroinflammation-in-preclinical-rodent-models-using-positron-emission-tomography
#13
Sara Gargiulo, Anna R Coda, Mariarosaria Panico, Matteo Gramanzini, Rosa M Moresco, Sylvie Chalon, Sabina Pappatà
INTRODUCTION: Neuroinflammation (NI) is an adaptive response to different noxious stimuli, involving microglia, astrocytes and peripheral immune cells. NI is a hallmark of several acute and chronic diseases of central nervous system (CNS) and contributes to both damage and repair of CNS tissue. EVIDENCE ACQUISITION: Interventional or genetically modified rodent models mimicking human neuropathologies may provide valuable insights on basic mechanisms of NI, but also for improving the development of new diagnostic and therapeutic strategies...
November 18, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27856009/redefining-ladd-s-path
#14
REVIEW
Mary E Fallat
Inspiration and innovation go hand in hand. Throughout history tragedies, including those personal and life altering, have inspired susceptible minds to find innovative ways to educate and tackle difficult problems. This address is first about origins. It weaves the story of how incredible individuals and events have shaped similar circumstances into not only our profession of pediatric surgery beginning with William E. Ladd, but also the emergency and trauma care system in this country. The address circles back to look at the past and future of our profession of pediatric surgery...
October 26, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27849456/the-bridging-advanced-developments-for-exceptional-rehabilitation-bader-consortium-reaching-in-partnership-for-optimal-orthopaedic-rehabilitation-outcomes
#15
Steven J Stanhope, Jason M Wilken, Alison L Pruziner, Christopher L Dearth, Marilynn Wyatt, Gregg W Ziemke, Rachel Strickland, Suzanne A Milbourne, Kenton R Kaufman
The Bridging Advanced Developments for Exceptional Rehabilitation (BADER) Consortium began in September 2011 as a cooperative agreement with the Department of Defense (DoD) Congressionally Directed Medical Research Programs Peer Reviewed Orthopaedic Research Program. A partnership was formed with DoD Military Treatment Facilities (MTFs), U.S. Department of Veterans Affairs (VA) Centers, the National Institutes of Health (NIH), academia, and industry to rapidly conduct innovative, high-impact, and sustainable clinically relevant research...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27831873/multi-modal-dictionary-learning-for-image-separation-with-application-in-art-investigation
#16
Nikos Deligiannis, Joao F C Mota, Bruno Cornelis, Miguel R D Rodrigues, Ingrid Daubechies
In support of art investigation, we propose a new source separation method that unmixes a single X-ray scan acquired from double-sided paintings. In this problem, the X-ray signals to be separated have similar morphological characteristics, which brings previous source separation methods to their limits. Our solution is to use photographs taken from the front-and back-side of the panel to drive the separation process. The crux of our approach relies on the coupling of the two imaging modalities (photographs and X-rays) using a novel coupled dictionary learning framework able to capture both common and disparate features across the modalities using parsimonious representations; the common component captures features shared by the multi-modal images, whereas the innovation component captures modality-specific information...
October 31, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27830347/mito-porter-for-mitochondrial-delivery-and-mitochondrial-functional-analysis
#17
Yuma Yamada, Hideyoshi Harashima
Mitochondria are attractive organelles that have the potential to contribute greatly to medical therapy, the maintenance of beauty and health, and the development of the life sciences. Therefore, it would be expected that the further development of mitochondrial drug delivery systems (DDSs) would exert a significant impact on the medical and life sciences. To achieve such an innovative objective, it will be necessary to deliver various cargoes to mitochondria in living cells. However, only a limited number of approaches are available for accomplishing this...
November 10, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27827832/multi-sensor-fusion-with-interaction-multiple-model-and-chi-square-test-tolerant-filter
#18
Chun Yang, Arash Mohammadi, Qing-Wei Chen
Motivated by the key importance of multi-sensor information fusion algorithms in the state-of-the-art integrated navigation systems due to recent advancements in sensor technologies, telecommunication, and navigation systems, the paper proposes an improved and innovative fault-tolerant fusion framework. An integrated navigation system is considered consisting of four sensory sub-systems, i.e., Strap-down Inertial Navigation System (SINS), Global Navigation System (GPS), the Bei-Dou2 (BD2) and Celestial Navigation System (CNS) navigation sensors...
November 2, 2016: Sensors
https://www.readbyqxmd.com/read/27822138/the-zebrafish-as-a-model-for-studying-neuroblastoma
#19
REVIEW
Diana Corallo, Simona Candiani, Michela Ori, Sanja Aveic, Gian Paolo Tonini
Neuroblastoma is a tumor arising in the peripheral sympathetic nervous system and is the most common cancer in childhood. Since most of the cellular and molecular mechanisms underlying neuroblastoma onset and progression remain unknown, the generation of new in vivo models might be appropriate to better dissect the peripheral sympathetic nervous system development in both physiological and disease states. This review is focused on the use of zebrafish as a suitable and innovative model to study neuroblastoma development...
2016: Cancer Cell International
https://www.readbyqxmd.com/read/27799562/networks-of-conforming-or-nonconforming-individuals-tend-to-reach-satisfactory-decisions
#20
Pouria Ramazi, James Riehl, Ming Cao
Binary decisions of agents coupled in networks can often be classified into two types: "coordination," where an agent takes an action if enough neighbors are using that action, as in the spread of social norms, innovations, and viral epidemics, and "anticoordination," where too many neighbors taking a particular action causes an agent to take the opposite action, as in traffic congestion, crowd dispersion, and division of labor. Both of these cases can be modeled using linear-threshold-based dynamics, and a fundamental question is whether the individuals in such networks are likely to reach decisions with which they are satisfied...
October 31, 2016: Proceedings of the National Academy of Sciences of the United States of America
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