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https://www.readbyqxmd.com/read/28319992/organizational-and-community-factors-associated-with-magnet-status-of-u-s-hospitals
#1
Teresa Wai Chi Tai, Sherry I Bame
The Magnet Recognition Program for healthcare organizations promotes excellence in nursing services and professional practices. However, organizational and community characteristics that contribute to the adoption of Magnet status remain unexplained. Investigating organizational and community factors will help determine systematic structural and contextual dimensions of Magnet hospitals previously shown to be more cost-effective in comparison with non-Magnet hospitals. Using the baseline 2005 database of all Magnet hospitals in the United States, the authors selected a matched sample to determine key organizational and community characteristics associated with Magnet adoption while controlling for regional and local factors...
January 2017: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/28314501/legal-and-regulatory-barriers-to-reverse-innovation
#2
Virginia Rowthorn, Alexander J Plum, John Zervos
BACKGROUND: Reverse innovation, or the importation of new, affordable, and efficacious models to high-income countries from the developing world, has emerged as a way to improve the health care system in the United States. Reverse innovation has been identified as a key emerging trend in global health systems in part because low-resourced settings are particularly good laboratories for low-cost/high-impact innovations that are developed out of necessity. A difficult question receiving scant attention is that of legal and regulatory barriers...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28303465/pharmacotherapy-in-generalized-anxiety-disorder-novel-experimental-medicine-models-and-emerging-drug-targets
#3
REVIEW
David S Baldwin, Ruihua Hou, Robert Gordon, Nathan T M Huneke, Matthew Garner
Many pharmacological and psychological approaches have been found efficacious in patients with generalized anxiety disorder (GAD), but many treatment-seeking patients will not respond and others will relapse despite continuing with interventions that initially had beneficial effects. Other patients will respond but then stop treatment early because of untoward effects such as sexual dysfunction, drowsiness, and weight gain. There is much scope for the development of novel approaches that could have greater overall effectiveness or acceptability than currently available interventions or that have particular effectiveness in specific clinical subgroups...
March 16, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28292531/stress-overeating-and-obesity-insights-from-human-studies-and-preclinical-models
#4
REVIEW
Maria Razzoli, Carolyn Pearson, Scott Crow, Alessandro Bartolomucci
Eating disorders and obesity have become predominant in human society. Their association to modern lifestyle, encompassing calorie-rich diets, psychological stress, and comorbidity with major diseases are well documented. Unfortunately the biological basis remains elusive and the pharmacological treatment inadequate, in part due to the limited availability of valid animal models. Human research on binge eating disorder (BED) proves a strong link between stress exposure and bingeing: state-levels of stress and negative affect are linked to binge eating in individuals with BED both in laboratory settings and the natural environment...
March 11, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28291598/identifying-radiology-s-place-in-the-expanding-landscape-of-episode-payment%C3%A2-models
#5
Andrew B Rosenkrantz, Joshua A Hirsch, Bibb Allen, H Benjamin Harvey, Gregory N Nicola
The current fee-for-service system for health care reimbursement in the United Stated is argued to encourage fragmented care delivery and a lack of accountability that predisposes to insufficient focus on quality as well as unnecessary or duplicative resource utilization. Episode payment models (EPMs) seek to improve coordination by linking payments for all services related to a patient's condition or procedure, thereby improving quality and efficiency of care. The CMS Innovation Center has implemented a broadening array of EPMs...
March 10, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28290239/an-innovative-design-for-cardiopulmonary-resuscitation-manikins-based-on-a-human-like-thorax-and-embedded-flow-sensors
#6
Mark Thielen, Rohan Joshi, Frank Delbressine, Sidarto Bambang Oetomo, Loe Feijs
Cardiopulmonary resuscitation manikins are used for training personnel in performing cardiopulmonary resuscitation. State-of-the-art cardiopulmonary resuscitation manikins are still anatomically and physiologically low-fidelity designs. The aim of this research was to design a manikin that offers high anatomical and physiological fidelity and has a cardiac and respiratory system along with integrated flow sensors to monitor cardiac output and air displacement in response to cardiopulmonary resuscitation. This manikin was designed in accordance with anatomical dimensions using a polyoxymethylene rib cage connected to a vertebral column from an anatomical female model...
March 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28289699/a-database-for-reproducible-manipulation-research-capridb-capture-print-innovate
#7
Florian T Pokorny, Yasemin Bekiroglu, Karl Pauwels, Judith Butepage, Clara Scherer, Danica Kragic
We present a novel approach and database which combines the inexpensive generation of 3D object models via monocular or RGB-D camera images with 3D printing and a state of the art object tracking algorithm. Unlike recent efforts towards the creation of 3D object databases for robotics, our approach does not require expensive and controlled 3D scanning setups and aims to enable anyone with a camera to scan, print and track complex objects for manipulation research. The proposed approach results in detailed textured mesh models whose 3D printed replicas provide close approximations of the originals...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28289223/biological-regulation-of-atmospheric-chemistry-en-route-to-planetary-oxygenation
#8
Gareth Izon, Aubrey L Zerkle, Kenneth H Williford, James Farquhar, Simon W Poulton, Mark W Claire
Emerging evidence suggests that atmospheric oxygen may have varied before rising irreversibly ∼2.4 billion years ago, during the Great Oxidation Event (GOE). Significantly, however, pre-GOE atmospheric aberrations toward more reducing conditions-featuring a methane-derived organic-haze-have recently been suggested, yet their occurrence, causes, and significance remain underexplored. To examine the role of haze formation in Earth's history, we targeted an episode of inferred haze development. Our redox-controlled (Fe-speciation) carbon- and sulfur-isotope record reveals sustained systematic stratigraphic covariance, precluding nonatmospheric explanations...
March 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28277097/towards-functional-antibody-based-vaccines-to-prevent-pre-erythrocytic-malaria-infection
#9
Brandon Sack, Stefan H I Kappe, D Noah Sather
An effective malaria vaccine would be considered a milestone of modern medicine, yet has so far eluded research and development efforts. This can be attributed to the extreme complexity of the malaria parasites, presenting with a multi-stage life cycle, high genome complexity and the parasite's sophisticated immune evasion measures, particularly antigenic variation during pathogenic blood stage infection. However, the pre-erythrocytic (PE) early infection forms of the parasite exhibit relatively invariant proteomes, and are attractive vaccine targets as they offer multiple points of immune system attack...
March 1, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28274741/a-systemic-evaluation-of-drug-in-acrylic-pressure-sensitive-adhesive-patch-in-vitro-and-in-vivo-the-roles-of-intermolecular-interaction-and-adhesive-mobility-variation-in-drug-controlled-release
#10
Chao Liu, Peng Quan, Shanshan Li, Yongshan Zhao, Liang Fang
Though acrylic pressure sensitive adhesives (PSAs) are widely used in transdermal drug delivery system, molecular details of drug-PSA interactions, PSA molecular mobility variations and their influences on drug skin permeation are unclear. In this study, three classes of acrylic PSAs containing hydroxyl (AAOH), carboxyl (AACOOH) and non-functional group (AAnone) were synthesized. Their abilities of controlling drug release were evaluated using propranolol (PRO) and zaltoprofen (ZAL) in vitro and in vivo. Interaction details were identified by FT-IR, solid-state NMR and molecular modeling...
March 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28269537/an-innovative-therapy-for-peri-implantitis-based-on-radio-frequency-electric-current-numerical-simulation-results-and-clinical-evidence
#11
G Cosoli, L Scalise, G Tricarico, E P Tomasini, G Cerri
Peri-implantitis is a severe inflammatory pathology that affects soit and hard tissues surrounding dental implants. Nowadays, only prevention is effective to contrast peri-implantitis, but, in recent years, there is the clinical evidence of the efficiency of a therapy based on the application of radio frequency electric current, reporting that 81% of the cases (66 implants, 46 patients) were successfully treated. The aim of this paper is to present the therapy mechanism, exploring the distribution of the electric currents in normal and pathologic tissues...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28259721/neuroendocrinology-and-brain-imaging-of-reward-in-eating-disorders-a-possible-key-to-the-treatment-of-anorexia-nervosa-and-bulimia-nervosa
#12
REVIEW
Alessio Maria Monteleone, Giovanni Castellini, Umberto Volpe, Valdo Ricca, Lorenzo Lelli, Palmiero Monteleone, Mario Maj
Anorexia nervosa and bulimia nervosa are severe eating disorders whose etiopathogenesis is still unknown. Clinical features suggest that eating disorders may develop as reward-dependent syndromes, since eating less food is perceived as rewarding in anorexia nervosa while consumption of large amounts of food during binge episodes in bulimia nervosa aims at reducing the patient's negative emotional states. Therefore, brain reward mechanisms have been a major focus of research in the attempt to contribute to the comprehension of the pathophysiology of these disorders...
March 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28257480/site-specific-gene-expression-profiling-as-a-novel-strategy-for-unravelling-keloid-disease-pathobiology
#13
N Jumper, T Hodgkinson, R Paus, A Bayat
Keloid disease (KD) is a fibroproliferative cutaneous tumour characterised by heterogeneity, excess collagen deposition and aggressive local invasion. Lack of a validated animal model and resistance to a multitude of current therapies has resulted in unsatisfactory clinical outcomes of KD management. In order to address KD from a new perspective, we applied for the first time a site-specific in situ microdissection and gene expression profiling approach, through combined laser capture microdissection and transcriptomic array...
2017: PloS One
https://www.readbyqxmd.com/read/28255682/variation-in-day-of-week-and-seasonal-concentrations-of-atmospheric-pm2-5-bound-metals-and-associated-health-risks-in-bangkok-thailand
#14
Siwatt Pongpiachan, Suixin Liu, Rujin Huang, Zhuzi Zhao, Jittree Palakun, Charnwit Kositanont, Junji Cao
While effective analytical techniques to promote the long-term intensive monitoring campaign of particulate heavy metals have been well established, efforts to interpret these toxic chemical contents into policy are lagging behind. In order to ameliorate the interpretation of evidence into policies, environmental scientists and public health practitioners need innovative methods to emphasize messages concerning adverse health effects to state and local policymakers. In this study, three different types of health risk assessment models categorized by exposure pathways...
March 2, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28237052/retention-in-buprenorphine-treatment-is-associated-with-improved-hcv-care-outcomes
#15
B L Norton, A Beitin, M Glenn, J DeLuca, A H Litwin, C O Cunningham
Persons who inject drugs, most of whom are opioid dependent, comprise the majority of the HCV infected in the United States. As the national opioid epidemic unfolds, increasing numbers of people are entering the medical system to access treatment for opioid use disorder, specifically with buprenorphine. Yet little is known about HCV care in patients accessing buprenorphine-based opioid treatment. We sought to determine the HCV prevalence, cascade of care, and the association between patient characteristics and completion of HCV cascade of care milestones for patients initiating buprenorphine treatment...
April 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28228576/ten-year-temporal-trends-in-medical-complications-after-acute-intracerebral-hemorrhage-in-the-united-states
#16
Fadar Oliver Otite, Priyank Khandelwal, Amer M Malik, Seemant Chaturvedi, Ralph L Sacco, Jose G Romano
BACKGROUND AND PURPOSE: Data on medical complications after intracerebral hemorrhage (ICH) are sparse. We assessed trends in the prevalence of urinary tract infection, pneumonia, sepsis, deep venous thrombosis (DVT), pulmonary embolism, acute renal failure (ARF), and acute myocardial infarction after ICH in the United States. METHODS: A total of 575 211 adult ICH cases were identified from the 2004 to 2013 Nationwide Inpatient Sample. Weighted complication risks were computed by sex and mechanical ventilation status...
February 22, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28227792/an-innovative-therapy-for-peri-implantitis-based-on-radio-frequency-electric-current-numerical-simulation-results-and-clinical-evidence
#17
G Cosoli, L Scalise, G Tricarico, E P Tomasini, G Cerri, G Cosoli, L Scalise, G Tricarico, E P Tomasini, G Cerri, G Cosoli, E P Tomasini, G Cerri, G Tricarico, L Scalise
Peri-implantitis is a severe inflammatory pathology that affects soit and hard tissues surrounding dental implants. Nowadays, only prevention is effective to contrast peri-implantitis, but, in recent years, there is the clinical evidence of the efficiency of a therapy based on the application of radio frequency electric current, reporting that 81% of the cases (66 implants, 46 patients) were successfully treated. The aim of this paper is to present the therapy mechanism, exploring the distribution of the electric currents in normal and pathologic tissues...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224500/automated-estimation-of-mouse-social-behaviors-based-on-a-hidden-markov-model
#18
Toshiya Arakawa, Akira Tanave, Aki Takahashi, Satoshi Kakihara, Tsuyoshi Koide, Takashi Tsuchiya
Recent innovations in sensing and Information and Communication Technology (ICT) have enabled researchers in animal behavior to collect an enormous amount of data. Consequently, the development of an automated system to substitute for some of the observations and analyses that are performed currently by expert researchers is becoming a crucial issue so that the vast amount of accumulated data can be processed efficiently. For this purpose, we introduce a process for the automated classification of the social interactive status of two mice in a square field on the basis of a Hidden Markov model (HMM)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28222770/what-do-patients-with-diabetes-and-providers-think-of-an-innovative-australian-model-of-remote-diabetic-retinopathy-screening-a-qualitative-study
#19
Nicola M Glasson, Sarah L Larkins, Lisa J Crossland
BACKGROUND: Diabetic retinopathy (DR) is the commonest cause of preventable blindness in working age populations, but up to 98% of visual loss secondary to DR can be prevented with early detection and treatment. In 2012, an innovative outreach DR screening model was implemented in remote communities in a state of Australia. The aim of this study was to explore the acceptability of this unique DR screening model to patients, health professionals and other key stakeholders. METHODS: This descriptive qualitative study used semi-structured interviews with patients opportunistically recruited whilst attending DR screening, and purposefully selected health care professionals either working within or impacted by the programme...
February 22, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28220752/putting-3d-modelling-and-3d-printing-into-practice-virtual-surgery-and-preoperative-planning-to-reconstruct-complex-post-traumatic-skeletal-deformities-and-defects
#20
Kevin Tetsworth, Steve Block, Vaida Glatt
3D printing technology has revolutionized and gradually transformed manufacturing across a broad spectrum of industries, including healthcare. Nowhere is this more apparent than in orthopaedics with many surgeons already incorporating aspects of 3D modelling and virtual procedures into their routine clinical practice. As a more extreme application, patient-specific 3D printed titanium truss cages represent a novel approach for managing the challenge of segmental bone defects. This review illustrates the potential indications of this innovative technique using 3D printed titanium truss cages in conjunction with the Masquelet technique...
2017: SICOT-J
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