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https://www.readbyqxmd.com/read/28531653/characteristics-needs-and-experiences-of-u-s-veterans-on-a-specialized-prison-unit
#1
Jack Tsai, Elizabeth Goggin
The Veterans Service Unit (VSU) in Connecticut is one of several all-veterans prison units that are being created throughout the United States. This study examined the characteristics, needs, and experiences of veterans on the Connecticut VSU. This study utilized data from a quality improvement survey that was completed by 87 of the 110 veterans on the Connecticut VSU (79% response rate). The majority of veterans on the VSU were white, aged 41-56, never married, and had an honorable or general military discharge making them potentially eligible for Veterans Affairs (VA) healthcare upon release...
May 17, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28529704/towards-a-systems-approach-for-chronic-diseases-based-on-health-state-modeling
#2
Michael Rebhan
Rising pressure from chronic diseases means that we need to learn how to deal with challenges at a different level, including the use of systems approaches that better connect across fragments, such as disciplines, stakeholders, institutions, and technologies. By learning from progress in leading areas of health innovation (including oncology and AIDS), as well as complementary indications (Alzheimer's disease), I try to extract the most enabling innovation paradigms, and discuss their extension to additional areas of application within a systems approach...
2017: F1000Research
https://www.readbyqxmd.com/read/28526869/blocking-of-carnitine-palmitoyl-transferase-1-potently-reduces-stress-induced-depression-in-rat-highlighting-a-pivotal-role-of-lipid-metabolism
#3
Anne Skøttrup Mørkholt, Ove Wiborg, Jette G K Nieland, Søren Nielsen, John Dirk Nieland
Major depressive disorder is a complex and common mental disease, for which the pathology has not been elucidated. The purpose of this study is to provide knowledge about the importance of mitochondrial dysfunction, dysregulated lipid metabolism and inflammation. Mitochondrial carnitine palmitoyl transferase 1a (CPT1a) is a key molecule involved in lipid metabolism and mutations in CPT1a causing reduced function is hypothesized to have a protective role in the development of depression. Moreover, CPT1a is found to be upregulated in suicide patients with history of depression...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521785/expect-with-me-development-and-evaluation-design-for-an-innovative-model-of-group-prenatal-care-to-improve-perinatal-outcomes
#4
Shayna D Cunningham, Jessica B Lewis, Jordan L Thomas, Stephanie A Grilo, Jeannette R Ickovics
BACKGROUND: Despite biomedical advances and intervention efforts, rates of preterm birth and other adverse outcomes in the United States have remained relatively intransigent. Evidence suggests that group prenatal care can reduce these risks, with implications for maternal and child health as well as substantial cost savings. However, widespread dissemination presents challenges, in part because training and health systems have not been designed to deliver care in a group setting. This manuscript describes the design and evaluation of Expect With Me, an innovative model of group prenatal care with a strong integrated information technology (IT) platform designed to be scalable nationally...
May 18, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28516800/undertriage-of-pediatric-major-trauma-patients-in-the-united-states
#5
Jin Peng, Krista Wheeler, Jonathan I Groner, Kathryn J Haley, Henry Xiang
Although trauma undertriage has been widely discussed in the literature, undertriage in the pediatric trauma population remains understudied. Using the 2009-2013 Nationwide Emergency Department Sample, we assessed the national undertriage rate in pediatric major trauma patients (age ≤16 years and injury severity score [ISS] >15), and identified factors associated with pediatric trauma undertriage. Nationally, 21.7% of pediatric major trauma patients were undertriaged. Children living in rural areas were more likely to be undertriaged ( P = ...
May 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28489262/mechanochemical-friedel-crafts-alkylation-a-sustainable-pathway-towards-porous-organic-polymers
#6
Erik Troschke, Sven Grätz, Tilo Lübken, Lars Borchardt
This study elucidates an innovative mechanochemical approach applying Friedel-Crafts alkylation to synthesize porous covalent triazine frameworks (CTFs). Herein, we pursue a counterintuitive approach by utilizing a rather destructive method to synthesize well-defined materials with intrinsic porosity. Investigating a model system including carbazole as monomer and cyanuric chloride as triazine node, ball milling is shown to successfully yield porous polymers almost quantitatively. We verified the successful structure formation by an in-depth investigation applying XPS, solid-state NMR and FT-IR spectroscopy...
May 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28479879/nutritional-status-feeding-practices-and-state-of-other-related-indicators-at-onset-of-a-multi-model-community-nutrition-intervention-program-in-mpigi-district-uganda
#7
Nazarius Mbona Tumwesigye, Florence Basiimwa Tushemerirwe, Richard Kajjura, Victoria Nabunya, Ronald Andrew Naitala, Cissie Namanda
INTRODUCTION: In Uganda, malnutrition level has persistently remained high among the under-fives and this has led NGOs like World Vision, Uganda into finding innovative ways for intervention. This paper presents an assessment of nutrition status and values of related indicators at onset of a community intervention program in four sub-counties of Mpigi district in Central Uganda. METHODS: This was a cross-sectional study to provide baseline information for a nutrition intervention...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28476699/analysis-and-detection-of-microporosities-in-aging-bones-in-context-to-pharmaceutical-treatment-a-study-in-line-of-osteoporosis
#8
Nadeem Baig, Muhammad Zaheer Khan
The objective of the current study was to evaluate the effects of nandrolone decanoate in terms of morphological changes in the diaphyseal region of appendicular skeleton long bone (femur) of aging female Albino rats with the help of innovatively designed histomorphometric tool of study being introduced first time mapped out micro porosities (lacunae) which tend to intensify as part of advanced aging denoting deterioration in osseous tissue. In fact our research trial has been in the line of involutional osteoporosis especially common in post-menopausal aged women, as to find out appropriate drug usefulness in the care and cure of this diseased state as per recommendation of FDA...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28475258/viii-the-past-present-and-future-of-developmental-methodology
#9
Todd D Little, Eugene W Wang, Britt K Gorrall
This chapter selectively reviews the evolution of quantitative practices in the field of developmental methodology. The chapter begins with an overview of the past in developmental methodology, discussing the implementation and dissemination of latent variable modeling and, in particular, longitudinal structural equation modeling. It then turns to the present state of developmental methodology, highlighting current methodological advances in the field. Additionally, this section summarizes ample quantitative resources, ranging from key quantitative methods journal articles to the various quantitative methods training programs and institutes...
June 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28472928/using-the-multiphase-optimization-strategy-most-to-optimize-an-hiv-care-continuum-intervention-for-vulnerable-populations-a-study-protocol
#10
Marya Viorst Gwadz, Linda M Collins, Charles M Cleland, Noelle R Leonard, Leo Wilton, Monica Gandhi, R Scott Braithwaite, David C Perlman, Alexandra Kutnick, Amanda S Ritchie
BACKGROUND: More than half of persons living with HIV (PLWH) in the United States are insufficiently engaged in HIV primary care and not taking antiretroviral therapy (ART), mainly African Americans/Blacks and Hispanics. In the proposed project, a potent and innovative research methodology, the multiphase optimization strategy (MOST), will be employed to develop a highly efficacious, efficient, scalable, and cost-effective intervention to increase engagement along the HIV care continuum...
May 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28468920/greater-than-the-sum-of-its-parts-modelling-population-contact-and-interaction-of-cultural-repertoires
#11
Nicole Creanza, Oren Kolodny, Marcus W Feldman
Evidence for interactions between populations plays a prominent role in the reconstruction of historical and prehistoric human dynamics; these interactions are usually interpreted to reflect cultural practices or demographic processes. The sharp increase in long-distance transportation of lithic material between the Middle and Upper Palaeolithic, for example, is seen as a manifestation of the cultural revolution that defined the transition between these epochs. Here, we propose that population interaction is not only a reflection of cultural change but also a potential driver of it...
May 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28467554/an-innovative-academic-progression-in-nursing-model-in-new-york-state
#12
Marianne Markowitz, Susan B Bastable
BACKGROUND: The Dual Degree Partnership in Nursing (DDPN) is a unique articulation model created in 2005 between two nursing programs that provides a seamless pathway for students to earn both an associate's degree and a bachelor's degree in nursing while benefiting from the strengths of each program. METHOD: Archival data has been systematically collected for a decade on admission, progression, retention, satisfaction, graduation, and NCLEX-RN pass rates to measure the reliability, validity, and integrity of this DDPN model for nursing education...
May 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28462501/innovative-pharmaceutical-approaches-for-the-management-of-inner-ear-disorders
#13
REVIEW
Umberto M Musazzi, Silvia Franzé, Francesco Cilurzo
The sense of hearing is essential for permitting human beings to interact with the environment, and its dysfunctions can strongly impact on the quality of life. In this context, the cochlea plays a fundamental role in the transformation of the airborne sound waves into electrical signals, which can be processed by the brain. However, several diseases and external stimuli (e.g., noise, drugs) can damage the sensorineural structures of cochlea, inducing progressive hearing dysfunctions until deafness. In clinical practice, the current pharmacological approaches to treat cochlear diseases are based on the almost exclusive use of systemic steroids...
May 1, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28459848/least-mean-square-fourth-based-microgrid-state-estimation-algorithm-using-the-internet-of-things-technology
#14
Md Masud Rana
This paper proposes an innovative internet of things (IoT) based communication framework for monitoring microgrid under the condition of packet dropouts in measurements. First of all, the microgrid incorporating the renewable distributed energy resources is represented by a state-space model. The IoT embedded wireless sensor network is adopted to sense the system states. Afterwards, the information is transmitted to the energy management system using the communication network. Finally, the least mean square fourth algorithm is explored for estimating the system states...
2017: PloS One
https://www.readbyqxmd.com/read/28456730/usefulness-of-pbpk-modeling-in-incorporation-of-clinical-conditions-in-personalized-medicine
#15
REVIEW
Niloufar Marsousi, Jules A Desmeules, Serge Rudaz, Youssef Daali
Personalized medicine aims to determine the most adequate treatment and dose regimen to obtain the maximum efficacy and minimum side effect by taking into account patients' characteristics. For numerous reasons one being ethical and methodological hurdles in including specific populations in clinical trials, innovative methods for optimization of drugs safety and efficacy in such patients have received increasing interest recently. Physiologically-Based PharmacoKinetic (PBPK) modeling has emerged as a promising approach in designing adequate clinical trials and quantifying anticipated changes in unknown clinical situations...
April 26, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28454025/review-and-analysis-of-strengths-and-weaknesses-of-agro-ecosystem-models-for-simulating-c-and-n-fluxes
#16
REVIEW
Lorenzo Brilli, Luca Bechini, Marco Bindi, Marco Carozzi, Daniele Cavalli, Richard Conant, Cristopher D Dorich, Luca Doro, Fiona Ehrhardt, Roberta Farina, Roberto Ferrise, Nuala Fitton, Rosa Francaviglia, Peter Grace, Ileana Iocola, Katja Klumpp, Joël Léonard, Raphaël Martin, Raia Silvia Massad, Sylvie Recous, Giovanna Seddaiu, Joanna Sharp, Pete Smith, Ward N Smith, Jean-Francois Soussana, Gianni Bellocchi
Biogeochemical simulation models are important tools for describing and quantifying the contribution of agricultural systems to C sequestration and GHG source/sink status. The abundance of simulation tools developed over recent decades, however, creates a difficulty because predictions from different models show large variability. Discrepancies between the conclusions of different modelling studies are often ascribed to differences in the physical and biogeochemical processes incorporated in equations of C and N cycles and their interactions...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28453640/pioneering-topological-methods-for-network-based-drug-target-prediction-by-exploiting-a-brain-network-self-organization-theory
#17
Claudio Durán, Simone Daminelli, Josephine M Thomas, V Joachim Haupt, Michael Schroeder, Carlo Vittorio Cannistraci
The bipartite network representation of the drug-target interactions (DTIs) in a biosystem enhances understanding of the drugs' multifaceted action modes, suggests therapeutic switching for approved drugs and unveils possible side effects. As experimental testing of DTIs is costly and time-consuming, computational predictors are of great aid. Here, for the first time, state-of-the-art DTI supervised predictors custom-made in network biology were compared-using standard and innovative validation frameworks-with unsupervised pure topological-based models designed for general-purpose link prediction in bipartite networks...
April 26, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28448780/integration-strategies-of-pharmacists-in-primary-care-based-accountable-care-organizations-a-report-from-the-accountable-care-organization-research-network-services-and-education
#18
Tina Joseph, Genevieve M Hale, Sara M Eltaki, Yesenia Prados, Renee Jones, Matthew J Seamon, Cynthia Moreau, Stephanie A Gernant
BACKGROUND: The accountable care organization (ACO) is an innovative health care delivery model centered on value-based care. ACOs consisting of primary care providers are increasingly becoming commonplace in practice; however, medication management remains suboptimal. PROGRAM DESCRIPTION: As experts in medication management, pharmacists perform direct patient care and assist in the transition from one provider to another, which places them in an ideal position to manage multiple aspects of patient care...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28446329/state-of-the-art-nanofabrication-in-catalysis
#19
Waiz Karim, Simon A Tschupp, Juan Herranz, Thomas J Schmidt, Yasin Ekinci, Jeroen A van Bokhovenac
We present recent developments in top-down nanofabrication that have found application in catalysis research. To unravel the complexity of catalytic systems, the design and use of models with control of size, morphology, shape and inter-particle distances is a necessity. The study of well-defined and ordered nanoparticles on a support contributes to the understanding of complex phenomena that govern reactions in heterogeneous and electro-catalysis. We review the strengths and limitations of different nanolithography methods such as electron beam lithography (EBL), photolithography, extreme ultraviolet (EUV) lithography and colloidal lithography for the creation of such highly tunable catalytic model systems and their applications in catalysis...
April 26, 2017: Chimia
https://www.readbyqxmd.com/read/28443622/the-rudy-study-using-digital-technologies-to-enable-a-research-partnership
#20
Harriet J A Teare, Joanna Hogg, Jane Kaye, Raashid Luqmani, Elaine Rush, Alison Turner, Laura Watts, Melanie Williams, M Kassim Javaid
Patients have extensive experience of their disease that can enhance the design and execution of research leading to significant innovations and efficiencies in the research process. The research community on the whole have been slow to adopt practices that enable patients to become active partners in research. Digital technologies are providing the means to do this more easily and so are increasingly being used to interact with patients and involve them in the design and execution of research. The RUDY (Rare UK Diseases of bone, joints and blood vessels) study's pioneering approach applies a custom-developed electronic platform where patients can contribute information over time about their disease experience, lifestyle and clinical history...
April 26, 2017: European Journal of Human Genetics: EJHG
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