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https://www.readbyqxmd.com/read/28448780/integration-strategies-of-pharmacists-in-primary-care-based-accountable-care-organizations-a-report-from-the-accountable-care-organization-research-network-services-and-education
#1
Tina Joseph, Genevieve M Hale, Sara M Eltaki, Yesenia Prados, Renee Jones, Matthew J Seamon, Cynthia Moreau, Stephanie A Gernant
BACKGROUND: The accountable care organization (ACO) is an innovative health care delivery model centered on value-based care. ACOs consisting of primary care providers are increasingly becoming commonplace in practice; however, medication management remains suboptimal. PROGRAM DESCRIPTION: As experts in medication management, pharmacists perform direct patient care and assist in the transition from one provider to another, which places them in an ideal position to manage multiple aspects of patient care...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28446329/state-of-the-art-nanofabrication-in-catalysis
#2
Waiz Karim, Simon A Tschupp, Juan Herranz, Thomas J Schmidt, Yasin Ekinci, Jeroen A van Bokhovenac
We present recent developments in top-down nanofabrication that have found application in catalysis research. To unravel the complexity of catalytic systems, the design and use of models with control of size, morphology, shape and inter-particle distances is a necessity. The study of well-defined and ordered nanoparticles on a support contributes to the understanding of complex phenomena that govern reactions in heterogeneous and electro-catalysis. We review the strengths and limitations of different nanolithography methods such as electron beam lithography (EBL), photolithography, extreme ultraviolet (EUV) lithography and colloidal lithography for the creation of such highly tunable catalytic model systems and their applications in catalysis...
April 26, 2017: Chimia
https://www.readbyqxmd.com/read/28443622/the-rudy-study-using-digital-technologies-to-enable-a-research-partnership
#3
Harriet J A Teare, Joanna Hogg, Jane Kaye, Raashid Luqmani, Elaine Rush, Alison Turner, Laura Watts, Melanie Williams, M Kassim Javaid
Patients have extensive experience of their disease that can enhance the design and execution of research leading to significant innovations and efficiencies in the research process. The research community on the whole have been slow to adopt practices that enable patients to become active partners in research. Digital technologies are providing the means to do this more easily and so are increasingly being used to interact with patients and involve them in the design and execution of research. The RUDY (Rare UK Diseases of bone, joints and blood vessels) study's pioneering approach applies a custom-developed electronic platform where patients can contribute information over time about their disease experience, lifestyle and clinical history...
April 26, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28443274/the-guatemala-penn-partners-an-innovative-inter-institutional-model-for-scientific-capacity-building-healthcare-education-and-public-health
#4
Maria Alejandra Paniagua-Avila, Elizabeth Messenger, Caroline A Nelson, Erwin Calgua, Frances K Barg, Kent W Bream, Charlene Compher, Anthony J Dean, Sergio Martinez-Siekavizza, Victor Puac-Polanco, Therese S Richmond, Rudolf R Roth, Charles C Branas
Population health outcomes are directly related to robust public health programs, access to basic health services, and a well-trained health-care workforce. Effective health services need to systematically identify solutions, scientifically test these solutions, and share generated knowledge. The World Health Organization (WHO)'s Global Healthcare Workforce Alliance states that the capacity to perform research is an essential factor for well-functioning public health systems. Low- and middle-income countries have greater health-care worker shortages and lower research capacity than higher-income countries...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28436866/universal-multimode-background-subtraction
#5
Hasan Sajid, Sen-Ching Samson Cheung
In this paper, we present a complete change detection system named Multimode Background Subtraction (MBS). The universal nature of system allows it to robustly handle multitude of challenges associated with video change detection such as illumination changes, dynamic background, camera jitter, moving camera etc. The system comprises of multiple innovative mechanisms in background modeling, model update, pixel classification and the use of multiple color spaces. The system first creates multiple background models of the scene followed by an initial foreground/background probability estimation for each pixel...
April 19, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28431621/two-decades-of-glatiramer-acetate-from-initial-discovery-to-the-current-development-of-generics
#6
REVIEW
Bianca Weinstock-Guttman, Kavita V Nair, Joseph L Glajch, Tanmoy C Ganguly, Daniel Kantor
Multiple sclerosis (MS) is a chronic, incurable, inflammatory disease of the central nervous system (CNS). In the United States, several US Food and Drug Administration (FDA)-approved disease-modifying treatments (DMTs) are available, including glatiramer acetate (GA; Copaxone®), one of the most longstanding treatments. GA was discovered serendipitously in the late 1960s/early 1970s while attempting to produce a synthetic antigen capable of inducing experimental autoimmune encephalomyelitis (EAE), an animal model of autoimmune inflammatory CNS disorders, including MS...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28426520/nursing-practice-research-and-education-in-the-west-the-best-is-yet-to-come
#7
Heather M Young, Susan Bakewell-Sachs, Linda Sarna
PURPOSE: This paper celebrates the 60th anniversary of the Western Institute of Nursing, the nursing organization representing 13 states in the Western United States, and envisions a preferred future for nursing practice, research, and education. BACKGROUND: Three landmark calls to action contribute to transforming nursing and healthcare: the Patient Protection and Affordable Care Act of 2010; the Institute of Medicine report Future of Nursing: Leading Change, Advancing Health; and the report Advancing Healthcare Transformation: A New Era for Academic Nursing...
May 2017: Nursing Research
https://www.readbyqxmd.com/read/28425554/on-the-parallelism-between-the-mechanisms-behind-chromatography-and-drug-delivery-the-role-of-interactions-with-a-stationary-phase
#8
Filippo Rossi, Franca Castiglione, Matteo Salvalaglio, Monica Ferro, Marta Moioli, Emanuele Mauri, Maurizio Masi, Andrea Mele
A huge number of studies and work in the drug delivery literature are focused on understanding and modeling transport phenomena, the pivotal point for a good device design. The rationalization of all phenomena involved is fundamental, but several concerns arise leaving many issues unsolved. In order to change the point of view we decided to focus our attention on the parallelisms between two fields that seem to be very far from each other: chromatography and drug release. Taking advantages of the studies conducted by many researchers using chromatographic columns we decided to explain all the phenomena involved in drug delivery considering sodium ibuprofen (IP) molecules as analytes and hydrogel as a stationary phase...
April 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28424626/a-rat-immobilization-model-based-on-cage-volume-reduction-a-physiological-model-for-bed-rest
#9
Enrica Marmonti, Sílvia Busquets, Míriam Toledo, Marina Ricci, Marc Beltrà, Victòria Gudiño, Francesc Oliva, José M López-Pedrosa, Manuel Manzano, Ricardo Rueda, Francisco J López-Soriano, Josep M Argilés
Bed rest has been an established treatment in the past prescribed for critically illness or convalescing patients, in order to preserve their body metabolic resource, to prevent serious complications and to support their rapid path to recovery. However, it has been reported that prolonged bed rest can have detrimental consequences that may delay or prevent the recovery from clinical illness. In order to study disuse-induced changes in muscle and bone, as observed during prolonged bed rest in humans, an innovative new model of muscle disuse for rodents is presented...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28422674/incorporation-of-efficient-second-order-solvers-into-latent-factor-models-for-accurate-prediction-of-missing-qos-data
#10
Xin Luo, MengChu Zhou, Shuai Li, YunNi Xia, Zhu-Hong You, QingSheng Zhu, Hareton Leung
Generating highly accurate predictions for missing quality-of-service (QoS) data is an important issue. Latent factor (LF)-based QoS-predictors have proven to be effective in dealing with it. However, they are based on first-order solvers that cannot well address their target problem that is inherently bilinear and nonconvex, thereby leaving a significant opportunity for accuracy improvement. This paper proposes to incorporate an efficient second-order solver into them to raise their accuracy. To do so, we adopt the principle of Hessian-free optimization and successfully avoid the direct manipulation of a Hessian matrix, by employing the efficiently obtainable product between its Gauss-Newton approximation and an arbitrary vector...
April 14, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28415149/integrating-teamstepps-%C3%A2-into-ambulatory-reproductive-health-care-early-successes-and-lessons-learned
#11
Maureen E Paul, Laura E Dodge, Evelyn Intondi, Guzey Ozcelik, Ken Plitt, Michele R Hacker
BACKGROUND: Most medical teamwork improvement interventions have occurred in hospitals, and more efforts are needed to integrate them into ambulatory care settings. In 2014, Affiliates Risk Management Services, Inc. (ARMS), the risk management services organization for a large network of reproductive health care organizations in the United States, launched a voluntary 5-year initiative to implement a medical teamwork system in this network using the TeamSTEPPS model. This article describes the ARMS initiative and progress made during the first 2 years, including lessons learned...
April 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/28412898/a-collaborative-process-for-evaluating-infant-mental-health-home-visiting-in-michigan
#12
Jamie M Lawler, Katherine L Rosenblum, Maria Muzik, Mary Ludtke, Deborah J Weatherston, Betty Tableman
This column describes an innovative collaboration in Michigan that could serve as a model for meaningful community-university-state partnerships. Recent legislation in Michigan threatened the infant mental health home visiting program, a service for Medicaid-eligible infants, toddlers, and families affected by mental illness. The University of Michigan is overseeing two major studies in collaboration with the Michigan Department of Health and Human Services, the Michigan Association for Infant Mental Health, the Michigan Infant Toddler Research Exchange faculty network, and community health service providers to determine the evidence base for the program and ensure its future success...
April 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28409699/potential-for-medicaid-savings-a-state-and-national-comparison-of-an-innovative-neonatal-abstinence-syndrome-treatment-model
#13
Lori Dickes, Julie Summey, Rachel Mayo, Jennifer Hudson, Windsor Westbrook Sherrill, Liwei Chen
In recent years, neonatal abstinence syndrome (NAS) rates have increased rapidly across the United States, rising from 1.2 (2000) to 5.8 (2012) per 1000 hospital births annually. Because most NAS infants are treated in an intensive care setting, associated hospital charges are high and continue to escalate, rising on average from $39,400 in 2000 to $66,700 in 2012. An innovative NAS treatment program, which includes early-initiated methadone therapy, rooming-in, and combined inpatient/outpatient weaning in a low-acuity nursery, has been in place since 2003 at a large Southeastern hospital...
April 14, 2017: Population Health Management
https://www.readbyqxmd.com/read/28403832/centering-and-racial-disparities-cradle-study-rationale-and-design-of-a-randomized-controlled-trial-of-centeringpregnancy-and-birth-outcomes
#14
Liwei Chen, Amy H Crockett, Sarah Covington-Kolb, Emily Heberlein, Lu Zhang, Xiaoqian Sun
BACKGROUND: In the United States, preterm birth (PTB) before 37 weeks gestational age occurs at an unacceptably high rate, and large racial disparities persist. To date, medical and public health interventions have achieved limited success in reducing rates of PTB. Innovative changes in healthcare delivery are needed to improve pregnancy outcomes. One such model is CenteringPregnancy group prenatal care (GPNC), in which individual physical assessments are combined with facilitated group education and social support...
April 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28401705/a-3d-virtual-reality-ophthalmoscopy-trainer
#15
Andrew S Wilson, Jake O'Connor, Lewis Taylor, David Carruthers
BACKGROUND: Performing eye examinations is an important clinical skill that medical students often find difficult to become proficient in. This paper describes the development and evaluation of an innovative 3D virtual reality (VR) training application to support learning these skills. METHODS: The VR ophthalmoscope was developed by a clinical team and technologist using the unity game engine, smartphone and virtual reality headset. It has a series of tasks that include performing systematic eye examinations, identifying common eye pathologies and a knowledge quiz...
April 12, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/28395110/murine-models-of-transplantation-tolerance-through-mixed-chimerism-advances-and-roadblocks
#16
REVIEW
Benedikt Mahr, Thomas Wekerle
Organ transplantation is the treatment of choice for patients with end-stage organ failure but chronic immunosuppression is taking its toll in terms of morbidity and poor efficacy in preventing late graft loss. Therefore a drug-free state would be desirable where the recipient permanently accepts a donor organ while remaining otherwise fully immunologically competent. Mouse studies unveiled mixed chimerism as an effective approach to deliberately induce such donor-specific tolerance and laid the foundation for a series of clinical pilot trials...
April 10, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28395011/metabolism-in-cardiomyopathy-every-substrate-matters
#17
Julia Ritterhoff, Rong Tian
Cardiac metabolism is highly adaptive to changes in fuel availability and the energy demand of the heart. This metabolic flexibility is key for the heart to maintain its output during the development and in response to stress. Alterations in substrate preference have been observed in multiple disease states; a clear understanding of their impact on cardiac function in the long term is critical for the development of metabolic therapies. In addition, the contribution of cellular metabolism to growth, survival, and other signalling pathways through the generation of metabolic intermediates has been increasingly noted, adding another layer of complexity to the impact of metabolism on cardiac function...
March 15, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28392263/precision-genome-editing-using-crispr-cas9-and-linear-repair-templates-in-c-elegans
#18
Alexandre Paix, Andrew Folkmann, Geraldine Seydoux
The ability to introduce targeted edits in the genome of model organisms is revolutionizing the field of genetics. State-of-the-art methods for precision genome editing use RNA-guided endonucleases to create double-strand breaks (DSBs) and DNA templates containing the edits to repair the DSBs. Following this strategy, we have developed a protocol to create precise edits in the C. elegans genome. The protocol takes advantage of two innovations to improve editing efficiency: direct injection of CRISPR-Cas9 ribonucleoprotein complexes and use of linear DNAs with short homology arms as repair templates...
April 6, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28386536/the-otago-exercise-program-innovative-delivery-models-to-maximize-sustained-outcomes-for-high-risk-homebound-older-adults
#19
Tiffany E Shubert, Lavinia Spring Goto, Matthew Lee Smith, Luohua Jiang, Holly Rudman, Marcia G Ory
BACKGROUND: It is estimated one in two adults age 80 and over fall each year, resulting in substantial morbidity and mortality rates among this oldest-old population. The Otago Exercise program (OEP) is an evidence-based fall prevention program shown to reduce falls by 35% among high-risk older adults. The OEP was designed to be delivered in the home by physical therapists. This model has encountered multiple implementation challenges in the United States health-care system, which has resulted in the development and testing of innovative models to support a broader reach and dissemination of this program...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28386079/multimodal-regulation-orchestrates-normal-and-complex-disease-states-in-the-retina
#20
A M Olivares, A S Jelcick, J Reinecke, B Leehy, A Haider, M A Morrison, L Cheng, D F Chen, M M DeAngelis, N B Haider
Regulation of biological processes occurs through complex, synergistic mechanisms. In this study, we discovered the synergistic orchestration of multiple mechanisms regulating the normal and diseased state (age related macular degeneration, AMD) in the retina. We uncovered gene networks with overlapping feedback loops that are modulated by nuclear hormone receptors (NHR), miRNAs, and epigenetic factors. We utilized a comprehensive filtering and pathway analysis strategy comparing miRNA and microarray data between three mouse models and human donor eyes (normal and AMD)...
April 6, 2017: Scientific Reports
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