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https://www.readbyqxmd.com/read/28725789/improving-american-healthcare-through-clinical-lab-2-0-a-project-santa-fe-report
#1
James M Crawford, Khosrow Shotorbani, Gaurav Sharma, Michael Crossey, Tarush Kothari, Thomas S Lorey, Jeffrey W Prichard, Myra Wilkerson, Nancy Fisher
Project Santa Fe was established both to provide thought leadership and to help develop the evidence base for the valuation of clinical laboratory services in the next era of American healthcare. The participants in Project Santa Fe represent major regional health systems that can operationalize laboratory-driven innovations and test their valuation in diverse regional marketplaces in the United States. We provide recommendations from the inaugural March 2016 meeting of Project Santa Fe. Specifically, in the transition from volume-based to value-based health care, clinical laboratories are called upon to provide programmatic leadership in reducing total cost of care through optimization of time-to-diagnosis and time-to-effective therapeutics, optimization of care coordination, and programmatic support of wellness care, screening, and monitoring...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28724152/cost-of-incremental-expansion-of-an-existing-family-medicine-residency-program
#2
Evan A Ashkin, Warren P Newton, Brian Toomey, Ronald Lingley, Cristen P Page
BACKGROUND AND OBJECTIVES: Expanding residency training programs to address shortages in the primary care workforce is challenged by the present graduate medical education (GME) environment. The Medicare funding cap on new GME positions and reductions in the Health Resources and Services Administration (HRSA) Teaching Health Center (THC) GME program require innovative solutions to support primary care residency expansion. Sparse literature exists to assist in predicting the actual cost of incremental expansion of a family medicine residency program without federal or state GME support...
July 2017: Family Medicine
https://www.readbyqxmd.com/read/28720701/de-novo-peptide-sequencing-by-deep-learning
#3
Ngoc Hieu Tran, Xianglilan Zhang, Lei Xin, Baozhen Shan, Ming Li
De novo peptide sequencing from tandem MS data is the key technology in proteomics for the characterization of proteins, especially for new sequences, such as mAbs. In this study, we propose a deep neural network model, DeepNovo, for de novo peptide sequencing. DeepNovo architecture combines recent advances in convolutional neural networks and recurrent neural networks to learn features of tandem mass spectra, fragment ions, and sequence patterns of peptides. The networks are further integrated with local dynamic programming to solve the complex optimization task of de novo sequencing...
July 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28717871/sleeve-gastrectomy-telementoring-a-sages-multi-institutional-quality-improvement-initiative
#4
Ninh T Nguyen, Allan Okrainec, Mehran Anvari, Brian Smith, Oz Meireles, Denise Gee, Erin Moran-Atkin, Evelyn Baram-Clothier, Diego R Camacho
BACKGROUND: Sleeve gastrectomy is a relatively new procedure that developed as a result of rapid innovation in the field of bariatric surgery. As with any newly developed operation, there is a learning curve that potentially can be associated with higher morbidity. Real-time surgical mentoring reduces the learning curve effect but can be time intensive for the mentor. The aim of this initiative was to evaluate the feasibility, effectiveness, and satisfaction of surgical telementoring for laparoscopic sleeve gastrectomy...
July 17, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28713168/creative-destruction-and-subjective-well-being
#5
Philippe Aghion, Ufuk Akcigit, Angus Deaton, Alexandra Roulet
In this paper we analyze the relationship between turnover-driven growth and subjective wellbeing. Our model of innovation-led growth and unemployment predicts that: (i) the effect of creative destruction on expected individual welfare should be unambiguously positive if we control for unemployment, less so if we do not; (ii) job creation has a positive and job destruction has a negative impact on wellbeing; (iii) job destruction has a less negative impact in US Metropolitan Statistical Areas (MSA) within states with more generous unemployment insurance policies; (iv) job creation has a more positive effect on individuals that are more forward-looking...
December 2016: American Economic Review
https://www.readbyqxmd.com/read/28704668/performance-and-implementation-of-low-impact-development-a-review
#6
REVIEW
Kyle Eckart, Zach McPhee, Tirupati Bolisetti
Climate change, urbanization, and ecological concerns are all driving the need for new stormwater management strategies. The effects of urbanization are exaggerated by climate change and thus the development of innovative stormwater management techniques are necessary to mitigate these impacts. One emerging stormwater management philosophy is low impact development (LID). LID utilizes distributed stormwater controls (often green infrastructure) as well as green spaces and natural hydrologic features in order to bring the hydrology of urban catchments closer to pre-development conditions...
July 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28700822/laser-desorption-postionization-mass-spectrometry-imaging-of-folic-acid-molecules-in-tumor-tissue
#7
Qiao Lu, Yongjun Hu, Jiaxin Chen, Shan Jin
Mass spectrometry imaging (MSI) is an innovative and powerful tool in biomedical research. It is well known that folic acid (FA) has a high affinity for folic acid receptor (FR) which is overexpressing in epithelial cancer. Herein, we propose a novel method to diagnose cancer through direct mapping of the label-free FA spatial distribution in tissue sections by state-of-the-art laser desorption postionization mass spectrometry imaging (LDPI-MSI). Compared with other tumor imaging methods, such as fluorescence imaging, photoacoustic imaging (PAI), magnetic resonance imaging (MRI) and micro-SPECT/CT, complicated synthesis and labeling processes are not required...
July 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28699524/biohybrid-membrane-systems-for-testing-molecules-and-stem-cell-therapy-in-neuronal-tissue-engineering
#8
Sabrina Morelli, Antonella Piscioneri, Simona Salerno, Enrico Drioli, Loredana De Bartolo
Current research in neural tissue-engineering is focused on the development of advanced biomaterials for the creation of sophisticated neuro-tissue analogues, showing that mimicking the in vivo tissue disposition and functions is a useful tool for the study of brain-related issues in normal and pathological states. In addition, the most common approach for developing new drug therapies is to carry out in vitro investigation before in vivo test, thus, it is increasingly important to develop valuable models that can predict the results of in vivo studies...
July 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28699357/adoption-of-robotic-assisted-partial-nephrectomies-a-population-based-analysis-of-u-s-surgeons-from-2004-2013
#9
Hoiwan Cheung, Ye Wang, Steven Chang, Yash S Khandwala, Francesco Del Giudice, Benjamin I Chung
INTRODUCTION: Urological surgeries have contributed to the increasing prevalence of minimally invasive robotic procedures. Although factors influencing the adoption of robotic-assisted radical prostatectomy have previously been identified, the explanation for the rapid rise in robotic partial nephrectomies remains unknown. Using a retrospective population-based sample, we attempt to determine hospital and surgeon-specific factors influencing a surgeon's decision to utilize robotic assistance for partial nephrectomies...
July 12, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28692211/integrating-hiv-and-substance-use-services-a-systematic-review
#10
Victoria Haldane, Francisco Cervero-Liceras, Fiona Lh Chuah, Suan Ee Ong, Georgina Murphy, Louise Sigfrid, Nicola Watt, Dina Balabanova, Sue Hogarth, Will Maimaris, Kent Buse, Peter Piot, Martin McKee, Pablo Perel, Helena Legido-Quigley
INTRODUCTION: Substance use is an important risk factor for HIV, with both concentrated in certain vulnerable and marginalized populations. Although their management differs, there may be opportunities to integrate services for substance use and HIV. In this paper we systematically review evidence from studies that sought to integrate care for people living with HIV and substance use problems. METHODS: Studies were included if they evaluated service integration for substance use and HIV...
May 30, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28688545/a-focus-on-the-state-of-the-art-of-food-waste-losses-issue-and-suggestions-for-future-researches
#11
Cinzia Muriana
Today, the role of the supply chain (SC) strategies in Food-Waste/Losses (F-W/L) generation is neglected, because F-W/L are generally considered an unavoidable consequence of accidental events. Therefore, only operating plans are today put into practice, which aim at reducing the impact of product losses along the SC. This involves that structured analyses and strategic SC approaches are not available for the prevention/minimization of F-W/L. The paper aims at changing the perspective, and promoting the hypothesis that generation of F-W/L mainly depends on the SC strategies put into practice that are usually optimized on the basis of the market demand...
July 5, 2017: Waste Management
https://www.readbyqxmd.com/read/28687554/innovative-models-for-providing-clinical-pharmacy-services-to-remote-locations-using-clinical-video-telehealth
#12
Cassie Perdew, Katie Erickson, Jessica Litke
PURPOSE: The use of videoconferencing and other telehealth technologies to expand access to clinical pharmacy services at multiple Veterans Affairs (VA) clinics in rural areas of Alaska and the northwestern United States is described. SUMMARY: Beginning in 2014, clinical pharmacy specialists at a regional VA Telehealth Hub based at Boise VA Medical Center in Idaho have provided telehealth services for 16 clinics. In one telehealth model, a pharmacist and other remotely located primary care team members (a medical provider, a medical support assistant, a social worker, and a psychologist) conduct telehealth visits with veterans located at VA clinics, with support provided by clinic-based nursing staff; this model has been used to improve medication management services for veterans in sparsely populated areas...
July 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28683828/virfinder-a-novel-k-mer-based-tool-for-identifying-viral-sequences-from-assembled-metagenomic-data
#13
Jie Ren, Nathan A Ahlgren, Yang Young Lu, Jed A Fuhrman, Fengzhu Sun
BACKGROUND: Identifying viral sequences in mixed metagenomes containing both viral and host contigs is a critical first step in analyzing the viral component of samples. Current tools for distinguishing prokaryotic virus and host contigs primarily use gene-based similarity approaches. Such approaches can significantly limit results especially for short contigs that have few predicted proteins or lack proteins with similarity to previously known viruses. METHODS: We have developed VirFinder, the first k-mer frequency based, machine learning method for virus contig identification that entirely avoids gene-based similarity searches...
July 6, 2017: Microbiome
https://www.readbyqxmd.com/read/28673313/mdm2-x-inhibitors-under-clinical-evaluation-perspectives-for-the-management-of-hematological-malignancies-and-pediatric-cancer
#14
REVIEW
Veronica Tisato, Rebecca Voltan, Arianna Gonelli, Paola Secchiero, Giorgio Zauli
The two murine double minute (MDM) family members MDM2 and MDMX are at the center of an intense clinical assessment as molecular target for the management of cancer. Indeed, the two proteins act as regulators of P53, a well-known key controller of the cell cycle regulation and cell proliferation that, when altered, plays a direct role on cancer development and progression. Several evidence demonstrated that functional aberrations of P53 in tumors are in most cases the consequence of alterations on the MDM2 and MDMX regulatory proteins, in particular in patients with hematological malignancies where TP53 shows a relatively low frequency of mutation while MDM2 and MDMX are frequently found amplified/overexpressed...
July 3, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28666809/bio-based-industries-joint-undertaking-the-catalyst-for-sustainable-bio-based-economic-growth-in-europe
#15
REVIEW
Philippe Mengal, Marcel Wubbolts, Eleni Zika, Ana Ruiz, Dieter Brigitta, Agata Pieniadz, Sarah Black
This article discusses the preparation, structure and objectives of the Bio-based Industries Joint Undertaking (BBI JU). BBI JU is a public-private partnership (PPP) between the European Commission (EC) and the Bio-based Industries Consortium (BIC), the industry-led private not-for-profit organisation representing the private sectors across the bio-based industries. The model of the public-private partnership has been successful as a new approach to supporting research and innovation and de-risking investment in Europe...
June 27, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28662594/-this-is-what-family-does-the-family-experience-of-caring-for-serious-illness
#16
Eric W Anderson, Katie M White
BACKGROUND: As the demographics of caregiving in United States evolve toward multigenerational, distributed family structures, the ways in which individuals and their families experience serious illness are changing. As part of a project to create an innovative model of supportive care for serious illness, a series of user interviews were conducted, forming the basis for this article. OBJECTIVE: To understand the experience of caregiving for individuals with serious illness from an intergenerational family perspective...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/28662250/surgeons-perspectives-on-premium-implants-in-total-joint-arthroplasty
#17
Amy S Wasterlain, Ricardo J Bello, Jonathan Vigdorchik, Ran Schwarzkopf, William J Long
Declining total joint arthroplasty reimbursement and rising implant prices have led many hospitals to restrict access to newer, more expensive total joint arthroplasty implants. The authors sought to understand arthroplasty surgeons' perspectives on implants regarding innovation, product launch, costs, and cost-containment strategies including surgeon gain-sharing and patient cost-sharing. Members of the International Congress for Joint Reconstruction were surveyed regarding attitudes about implant technology and costs...
June 29, 2017: Orthopedics
https://www.readbyqxmd.com/read/28658018/team-investment-and-longitudinal-relationships-an-innovative-global-health-education-model
#18
Kimberly R Myers, N Benjamin Fredrick
PROBLEM: Increasing student interest in global health has resulted in medical schools offering more global health opportunities. However, concerns have been raised, particularly about one-time, short-term experiences, including lack of follow-through for students and perpetuation of unintentional messages of global health heroism, neocolonialism, and disregard for existing systems and communities of care. Medical schools must develop global health programs that address these issues. APPROACH: The Global Health Scholars Program (GHSP) was created in 2008-2009 at Penn State College of Medicine...
June 27, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28652243/clinical-pathways-recommendations-for-putting-patients-at-the-center-of-value-based-care
#19
Edward Abrahams, Alan Balch, Patricia Goldsmith, Marcia Kean, Amy M Miller, Gilbert Omenn, Ellen Sonet, John Sprandio, Courtney Tyne, Kimberly Westrich
Two major trends that have been affecting the provision of oncology care in the United States are a shift from volume-based to value-based care and a push toward patient-centered healthcare. However, these two trends are not always completely aligned with each other. Value-based payment models, including clinical pathways, are one strategy being implemented by oncology stakeholders to help encourage the uptake of value-based oncology care. If structured with the patient in mind, they can improve quality of care for patients with cancer, decrease inappropriate care while enabling appropriate personalization of care, and constrain rising prices by demanding a stronger link between cost and value...
June 26, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28652166/multilingual-self-management-resources-for-prostate-cancer-survivors-and-their-partners-results-of-a-long-term-academic-state-health-department-partnership-to-promote-survivorship-care
#20
Ted A Skolarus, Jennifer A Ragnoni, Carol Garlinghouse, Ann Schafenacker, Debbie Webster, Polly Hager, Daniela Wittmann, Laurel Northouse
INTRODUCTION: There is increasing need for innovative, sustainable ways to provide evidence-based self-management information and supportive care for prostate cancer survivors and their partners. For these reasons, we describe how an academic-public partnership facilitated the broad dissemination of evidence-based, multilingual survivorship educational materials via a state-managed prostate cancer website. METHODS: We outline the steps of an academic-public partnership leading to dissemination of online, survivorship materials as a resource for prostate cancer survivors and their partners...
June 23, 2017: Urology
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