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https://www.readbyqxmd.com/read/28448778/economic-impact-of-above-label-dosing-with-etanercept-adalimumab-or-ustekinumab-in-patients-with-psoriasis
#1
Steven R Feldman, Yang Zhao, Huanxue Zhou, Vivian Herrera, Haijun Tian, Yunfeng Li
BACKGROUND: Patients with moderate-to-severe psoriasis may be treated with above-label doses of biologics in an attempt to optimize outcomes. Dose escalation will have an effect on the cost of treatment. OBJECTIVE: To examine costs related to above-label use of etanercept, adalimumab, and ustekinumab among patients with moderate-to-severe psoriasis. METHODS: A retrospective study was performed using a large U.S. claims database. Patients were included in the study if they were aged ≥ 18 years with a diagnosis of psoriasis (excluding psoriatic arthritis) and had at least 1 medication fill for etanercept, adalimumab, or ustekinumab between January 1, 2011, and June 30, 2012...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28427553/familial-pulmonary-fibrosis-clinical-and-radiological-characteristics-and-progression-analysis-in-different-high-resolution-ct-patterns
#2
David Bennett, Maria Antonietta Mazzei, Nevada Cioffi Squitieri, Elena Bargagli, Rosa Metella Refini, Antonella Fossi, Luca Volterrani, Paola Rottoli
BACKGROUND: Familial pulmonary fibrosis (FPF) is defined as an idiopathic diffuse parenchymal lung disease affecting two or more members of the same primary biological family. The aim of the present study was to contribute to the clinical, functional and radiological characterisation of FPF with particular regards to disease progression and survival. METHODS: Baseline clinical, functional and radiological data of a FPF population (n = 46 patients) were retrospectively collected and analysed according to the 2011 IPF guidelines HRCT classification...
May 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28419978/dissolved-oxygen-stream-temperature-and-fish-habitat-response-to-environmental-water-purchases
#3
Sarah E Null, Nathaniel R Mouzon, Logan R Elmore
Environmental water purchases are increasingly used for ecological protection. In Nevada's Walker Basin (western USA), environmental water purchases augment streamflow in the Walker River and increase lake elevation of terminal Walker Lake. However, water quality impairments like elevated stream temperatures and low dissolved oxygen concentrations also limit ecosystems and species, including federally-threatened Lahontan cutthroat trout. In this paper, we prioritize water volumes and locations that most enhance water quality for riverine habitat from potential environmental water rights purchases...
April 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28419257/rodent-pika-parasite-spillover-in-western-north-america
#4
Patrick Foley, Tara Roth, Janet Foley, Chris Ray
Competition during the Cenozoic expansion of the Rodentia may have contributed to ecological niche reduction of pikas, which are now increasingly under threat as their habitat degrades under global climate change, while some rodents expand their ranges and overlap with pikas. Range overlap carries the possibility of disease spillover. Contemporary North American pikas are cold-adapted and relegated primarily to alpine environments where they subsist on relatively low-quality herbaceous diet. Yet their evolutionary ancestors were distributed geographically even into the subtropics...
April 15, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28413848/impact-of-data-model-and-point-density-on-aboveground-forest-biomass-estimation-from-airborne-lidar
#5
Mariano Garcia, Sassan Saatchi, Antonio Ferraz, Carlos Alberto Silva, Susan Ustin, Alexander Koltunov, Heiko Balzter
BACKGROUND: Accurate estimation of aboveground forest biomass (AGB) and its dynamics is of paramount importance in understanding the role of forest in the carbon cycle and the effective implementation of climate change mitigation policies. LiDAR is currently the most accurate technology for AGB estimation. LiDAR metrics can be derived from the 3D point cloud (echo-based) or from the canopy height model (CHM). Different sensors and survey configurations can affect the metrics derived from the LiDAR data...
December 2017: Carbon Balance and Management
https://www.readbyqxmd.com/read/28412454/new-insights-into-the-toxicity-of-mineral-fibres-a-combined-in-situ-synchrotron-%C3%AE-xrd-and-hr-tem-study-of-chrysotile-crocidolite-and-erionite-fibres-found-in-the-tissues-of-sprague-dawley-rats
#6
Alessandro F Gualtieri, Nicola Bursi Gandolfi, Simone Pollastri, Manfred Burghammer, Eva Tibaldi, Fiorella Belpoggi, Kilian Pollok, Falko Langenhorst, Ruggero Vigliaturo, Goran Dražić
Along the line of the recent research topic aimed at understanding the in vivo activity of mineral fibres and their mechanisms of toxicity, this work describes the morpho-chemical characteristics of the mineral fibres found in the tissues of Sprague-Dawley rats subjected to intraperitoneal/intrapleural injection of UICC chrysotile, UICC crocidolite and erionite-Na from Nevada (USA). The fibres are studied with in situ synchrotron powder diffraction and high resolution transmission electron microscopy to improve our understanding of the mechanisms of toxicity of these mineral fibres...
April 12, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28405402/absence-of-population-structure-across-elevational-gradients-despite-large-phenotypic-variation-in-mountain-chickadees-poecile-gambeli
#7
Carrie L Branch, Joshua P Jahner, Dovid Y Kozlovsky, Thomas L Parchman, Vladimir V Pravosudov
Montane habitats are characterized by predictably rapid heterogeneity along elevational gradients and are useful for investigating the consequences of environmental heterogeneity for local adaptation and population genetic structure. Food-caching mountain chickadees inhabit a continuous elevation gradient in the Sierra Nevada, and birds living at harsher, high elevations have better spatial memory ability and exhibit differences in male song structure and female mate preference compared to birds inhabiting milder, low elevations...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28395142/tax-avoidance-and-evasion-cigarette-purchases-from-indian-reservations-among-us-adult-smokers-2010-2011
#8
Xu Wang, Xin Xu, Michael A Tynan, Robert B Gerzoff, Ralph S Caraballo, Gabbi R Promoff
Excise taxes are the primary public health strategy used to increase the price of cigarettes in the United States. Rather than quitting or reducing consumption of cigarettes, some price-sensitive smokers may avoid state and local excise taxes by purchasing cigarettes from Indian reservations. The objectives of this study were to (1) provide the most recent state-specific prevalence of purchases made on Indian reservations by non-American Indians/Alaska Natives (non-AI/ANs) and (2) assess the impact of these purchases on state tax revenues...
May 2017: Public Health Reports
https://www.readbyqxmd.com/read/28390305/reactive-transport-in-the-complex-heterogeneous-alluvial-aquifer-of-fortymile-wash-nevada
#9
Mohamad Reza Soltanian, Alexander Sun, Zhenxue Dai
Yucca Mountain, Nevada, had been extensively investigated as a potential deep geologic repository for storing high-level nuclear wastes. Previous field investigations of stratified alluvial aquifer downstream of the site revealed that there is a hierarchy of sedimentary facies types. There is a corresponding log conductivity and reactive surface area subpopulations within each facies at each scale of sedimentary architecture. Here we use a Lagrangian-based transport model in order to analyze radionuclide dispersion in the saturated alluvium of Fortymile Wash, Nevada...
July 2017: Chemosphere
https://www.readbyqxmd.com/read/28380728/underlying-motivations-of-volunteering-across-life-stages
#10
Takashi Yamashita, Jennifer R Keene, Chi-Jung Lu, Dawn C Carr
Volunteering is beneficial not only for individuals' well-being but also for society's well-being; yet only a fraction of U.S. citizens regularly engage in volunteer activities. This study examined how underlying motivations are associated with interest in volunteering for individuals in three major life phases: early, middle, and later adulthood. Data were collected from 1,046 adults who volunteered through nonprofit organizations in Nevada (USA). Exploratory factor analysis revealed that community service, career advancement, and well-being were common underlying motivations for individuals across life stages...
March 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/28376670/in-re-guardianship-of-hailu-the-nevada-supreme-court-casts-doubt-on-the-standard-for-brain-death-diagnosis
#11
Greg Yanke, Mohamed Y Rady, Joseph L Verheijde
In the recent court case of In Re Guardianship of Hailu, the Nevada Supreme Court cast doubt on the acceptability of the American Academy of Neurology's guidelines as a medical standard for determining brain death. The Uniform Determination of Death Act, which has been adopted in every state, requires that brain death diagnoses be made in accordance with accepted medical standards. The Court expressed concern that the guidelines fail to ensure that there is an irreversible cessation of all functions of a person's entire brain, which is a component of the Act's definition of death...
January 1, 2017: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/28370925/evaluating-a-new-method-for-reconstructing-forest-conditions-from-general-land-office-survey-records
#12
Carrie R Levine, Charles V Cogbill, Brandon M Collins, Andrew J Larson, James A Lutz, Malcolm P North, Christina M Restaino, Hugh D Safford, Scott L Stephens, John J Battles
Historical forest conditions are often used to inform contemporary management goals because historical forests are considered to be resilient to ecological disturbances. The General Land Office (GLO) surveys of the late nineteenth and early twentieth centuries provide regionally quasi-contiguous datasets of historical forests across much of the Western United States. Multiple methods exist for estimating tree density from point-based sampling such as the GLO surveys, including distance-based and area-based approaches...
March 28, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28367439/mr-lymphangiography-a-practical-guide-to-perform-it-and-a-brief-review-of-the-literature-from-a-technical-point-of-view
#13
Francesco Giuseppe Mazzei, Francesco Gentili, Susanna Guerrini, Nevada Cioffi Squitieri, Duccio Guerrieri, Paolo Gennaro, Michele Scialpi, Luca Volterrani, Maria Antonietta Mazzei
We propose a practical approach for performing high-resolution MR lymphangiography (MRL). We shall discuss and illustrate the technical approach for the visualization of lymphatic vessels in patients suffering from lymphedema, how to distinguish lymphatic vessels from veins, and MRL role in supermicrosurgery treatment planning. A brief review of literature, from a technical point of view, is also reported.
2017: BioMed Research International
https://www.readbyqxmd.com/read/28364610/groundwater-discharge-in-high-mountain-watersheds-a-valuable-resource-for-downstream-semi-arid-zones-the-case-of-the-b%C3%A3-rchules-river-in-sierra-nevada-southern-spain
#14
Jorge Jódar, José Antonio Cabrera, Sergio Martos-Rosillo, Ana Ruiz-Constán, Antonio González-Ramón, Luis Javier Lambán, Christian Herrera, Emilio Custodio
Aquifers in permeable formations developed in high-mountain watersheds slow down the transfer of snowmelt to rivers, modifying rivers' flow pattern. To gain insight into the processes that control the hydrologic response of such systems the role played by groundwater in an alpine basin located at the southeastern part of the Iberian Peninsula is investigated. As data in these environments is generally scarce and its variability is high, simple lumped parameter hydrological models that consider the groundwater component and snow accumulation and melting are needed...
March 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28359397/health-impact-assessment-as-an-instrument-to-examine-the-health-implications-of-education-policies
#15
J Pharr, M Gakh, C Coughenour, S Clark
OBJECTIVES: Health impact assessment (HIA) is a systematic process that can be used by public health professionals to examine the potential health effects of a policy, plan, program, or project that originates outside of the health sector. This article presents a case study of how an interdisciplinary team utilized an HIA to analyze the potential health impact of full-day kindergarten (FDK) on communities in Nevada. STUDY DESIGN: Case study. METHODS: With stakeholder and community engagement, we conducted a multistage HIA that included qualitative and quantitative data collection and analysis, a review of existing literature, and projections...
April 2017: Public Health
https://www.readbyqxmd.com/read/28348371/dust-outpaces-bedrock-in-nutrient-supply-to-montane-forest-ecosystems
#16
S M Aciego, C S Riebe, S C Hart, M A Blakowski, C J Carey, S M Aarons, N C Dove, J K Botthoff, K W W Sims, E L Aronson
Dust provides ecosystem-sustaining nutrients to landscapes underlain by intensively weathered soils. Here we show that dust may also be crucial in montane forest ecosystems, dominating nutrient budgets despite continuous replacement of depleted soils with fresh bedrock via erosion. Strontium and neodymium isotopes in modern dust show that Asian sources contribute 18-45% of dust deposition across our Sierra Nevada, California study sites. The remaining dust originates regionally from the nearby Central Valley...
March 28, 2017: Nature Communications
https://www.readbyqxmd.com/read/28334396/quantifying-circular-rna-expression-from-rna-seq-data-using-model-based-framework
#17
Musheng Li, Xueying Xie, Jing Zhou, Mengying Sheng, Xiaofeng Yin, Eun-A Ko, Tong Zhou, Wanjun Gu
Motivation: Circular RNAs (circRNAs) are a class of non-coding RNAs that are widely expressed in various cell lines and tissues of many organisms. Although the exact function of many circRNAs is largely unknown, the cell type- and tissue-specific circRNA expression has implicated their crucial functions in many biological processes. Hence, the quantification of circRNA expression from high-throughput RNA-seq data is becoming important to ascertain. Although many model-based methods have been developed to quantify linear RNA expression from RNA-seq data, these methods are not applicable to circRNA quantification...
March 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28316116/water-availability-drives-signatures-of-local-adaptation-in-whitebark-pine-pinus-albicaulis-englm-across-fine-spatial-scales-of-the-lake-tahoe-basin-usa
#18
Brandon M Lind, Christopher J Friedline, Jill L Wegrzyn, Patricia E Maloney, Detlev R Vogler, David B Neale, Andrew J Eckert
Patterns of local adaptation at fine spatial scales are central to understanding how evolution proceeds, and are essential to the effective management of economically and ecologically important forest tree species. Here, we employ single and multilocus analyses of genetic data (n = 116,231 SNPs) to describe signatures of fine-scale adaptation within eight whitebark pine (Pinus albicaulis Engelm.) populations across the local extent of the environmentally heterogeneous Lake Tahoe Basin, USA. We show that despite highly shared genetic variation (FST = 0...
March 17, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28263664/abstracts-of-the-2017-aans-cns-joint-section-on-disorders-of-the-spine-and-peripheral-nerves-las-vegas-nevada-%C3%A2-march-8-11-2017
#19
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28262572/evaluation-of-multiple-tracer-methods-to-estimate-low-groundwater-flow-velocities
#20
Paul W Reimus, Bill W Arnold
Four different tracer methods were used to estimate groundwater flow velocity at a multiple-well site in the saturated alluvium south of Yucca Mountain, Nevada: (1) two single-well tracer tests with different rest or "shut-in" periods, (2) a cross-hole tracer test with an extended flow interruption, (3) a comparison of two tracer decay curves in an injection borehole with and without pumping of a downgradient well, and (4) a natural-gradient tracer test. Such tracer methods are potentially very useful for estimating groundwater velocities when hydraulic gradients are flat (and hence uncertain) and also when water level and hydraulic conductivity data are sparse, both of which were the case at this test location...
February 20, 2017: Journal of Contaminant Hydrology
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