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https://www.readbyqxmd.com/read/28340351/bedside-back-to-bench-building-bridges-between-basic-and-clinical-genomic-research
#1
Teri A Manolio, Douglas M Fowler, Lea M Starita, Melissa A Haendel, Daniel G MacArthur, Leslie G Biesecker, Elizabeth Worthey, Rex L Chisholm, Eric D Green, Howard J Jacob, Howard L McLeod, Dan Roden, Laura Lyman Rodriguez, Marc S Williams, Gregory M Cooper, Nancy J Cox, Gail E Herman, Stephen Kingsmore, Cecilia Lo, Cathleen Lutz, Calum A MacRae, Robert L Nussbaum, Jose M Ordovas, Erin M Ramos, Peter N Robinson, Wendy S Rubinstein, Christine Seidman, Barbara E Stranger, Haoyi Wang, Monte Westerfield, Carol Bult
Genome sequencing has revolutionized the diagnosis of genetic diseases. Close collaborations between basic scientists and clinical genomicists are now needed to link genetic variants with disease causation. To facilitate such collaborations, we recommend prioritizing clinically relevant genes for functional studies, developing reference variant-phenotype databases, adopting phenotype description standards, and promoting data sharing.
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28340216/meta-analysis-of-statins-in-chronic-kidney-disease-who-benefits
#2
C M Messow, C Isles
Background: Attempts to reduce the burden of vascular disease in advanced chronic kidney disease (CKD) by control of lipids have not been as successful as predicted. Aim: : To determine the extent to which the effectiveness of statins varies by kidney class. Design: Meta-analysis. Methods: We selected randomized trials of statin vs. placebo that gave outcomes for CKD3 (eGFR 30-59 ml/min), CKD4 (eGFR 15-29 ml/min), CKD5 (eGFR < 15 ml/min)/5D(dialysis) and transplant patients separately...
March 14, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28340189/the-relationship-between-pain-severity-and-alcohol-use-among-school-aged-children-and-adolescents-the-moderating-role-of-drinking-motives
#3
Claudia Horn-Hofmann, Zina Trost, Anne Hublet, Sylvie Mrug, Joris Van Damme, Tine Vervoort
Objective. : Evidence from adult samples suggests a co-occurrence between pain and alcohol abuse. However, studies in adolescents are scarce and results are inconsistent, with some studies observing heightened and others observing reduced alcohol consumption in adolescents suffering from pain. We hypothesized that in adolescents the association between pain and alcohol use will be moderated by drinking motives. Methods. : Data from a large representative sample of Flemish school children and adolescents (N = 10,650, 50...
March 15, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28340092/community-based-effectiveness-trials-as-a-means-to-disseminate-evidence-based-and-culturally-responsive-behavioral-health-interventions
#4
Flavio F Marsiglia, Patricia Dustman, Mary Harthun, Chelsea Coyne Ritland, Adriana Umaña-Taylor
This article adds to the existing knowledge about innovative community-based approaches used to reduce and eliminate behavioral health disparities. Special attention is given to culturally appropriate interventions that increase access to care and that improve the quality of behavioral health services across different geographic regions and communities. Effectiveness trials are presented as appropriate tools to translate existing efficacious interventions into real-world settings. This article describes how to transition from efficacy to effectiveness, including factors essential to consider from the perspectives of university-based research teams and community-based organizations (CBOs)...
March 14, 2017: Health & Social Work
https://www.readbyqxmd.com/read/28340077/idiopathic-non-lupus-full-house-nephropathy-is-associated-with-poor-renal-outcome
#5
Emilie C Rijnink, Y K Onno Teng, Tineke Kraaij, Ron Wolterbeek, Jan A Bruijn, Ingeborg M Bajema
Background.: Full-house immunofluorescence in combination with various histopathologic lesions in the renal biopsies of patients without overt systemic lupus erythematosus (SLE) poses a diagnostic challenge. In this setting, the biopsy findings are sometimes termed non-lupus 'full-house nephropathy' (FHN). It is presently unknown whether idiopathic non-lupus FHN is clinicopathologically and prognostically distinct from lupus FHN. Methods.: We included non-lupus FHN patients and lupus FHN controls (four or more American College of Rheumatology or Systemic Lupus International Collaborating Clinics criteria) who were biopsied between 1968 and 2014 at the Leiden University Medical Centre...
March 13, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339975/the-pain-interprofessional-curriculum-design-model
#6
Judy Watt-Watson, Leila Lax, Robyn Davies, Sylvia Langlois, Jon Oskarsson, Lalitha Raman-Wilms
Objective.:  Although the University of Toronto Centre for the Study of Pain has successfully implemented an Interfaculty Pain Curriculum since 2002, we have never formalized the process in a design model. Therefore, our primary aim was to develop a model that provided an overview of dynamic, interrelated elements that have been important in our experience. A secondary purpose was to use the model to frame an interactive workshop for attendees interested in developing their own pain curricula...
March 3, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339797/the-american-society-for-clinical-pathology-s-2015-wage-survey-of-medical-laboratories-in-the-united-states
#7
Edna Garcia, Patrick B Fisher
Objectives: To inform the pathology and laboratory field of the most recent national wage data from the American Society for Clinical Pathology (ASCP). Historically, the results of this biennial survey have served as a basis for additional research on laboratory recruitment, retention, education, marketing, certification, and advocacy. Methods: The 2015 wage survey was conducted through collaboration between the ASCP's Institute of Science, Technology, & Policy in Washington, DC, and the ASCP Board of Certification in Chicago, Illinois...
February 26, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28339617/searching-for-the-smoker-s-paradox-in-acute-stroke-patients-treated-with-intravenous-thrombolysis
#8
Haitham M Hussein, Nicki Niemann, Emily D Parker, Adnan I Qureshi
Background: Inconsistent evidence supports better outcome in smokers after stroke. Our study examines this association in a large sample of ischemic stroke treated with intravenous thrombolysis. Method: Virtual International Stroke Trials Archive (VISTA) database, composed of individual patient data of multiple clinical trials, was queried. The primary outcome was functional independence at 3 months noted by modified Rankin Scale (mRS; a 7-point scale ranging from 0 [no deficit] to 6 [death]) score≤ 2...
January 28, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28339592/active-collaboration-with-clients-an-underemphasized-but-vital-part-of-evidence-based-practice
#9
James Drisko
Evidence-based practice (EBP) is a widely recognized concept in contemporary social work practice. However, recent studies have shown that social workers do not understand EBP correctly. Standardized administrative approaches to implementing EBP have led to confusion about its core practice decision-making process. This collaborative process is the heart of EBP in direct social work practice. This article explores the EBP process and addresses a vital but often underemphasized step of EBP: active collaboration with the client in decision making...
January 28, 2017: Social Work
https://www.readbyqxmd.com/read/28339563/trauma-informed-social-work-practice
#10
Jill Levenson
Social workers frequently encounter clients with a history of trauma. Trauma-informed care is a way of providing services by which social workers recognize the prevalence of early adversity in the lives of clients, view presenting problems as symptoms of maladaptive coping, and understand how early trauma shapes a client's fundamental beliefs about the world and affects his or her psychosocial functioning across the life span. Trauma-informed social work incorporates core principles of safety, trust, collaboration, choice, and empowerment and delivers services in a manner that avoids inadvertently repeating unhealthy interpersonal dynamics in the helping relationship...
January 23, 2017: Social Work
https://www.readbyqxmd.com/read/28339428/does-conservative-treatment-change-the-brain-in-patients-with-chronic-musculoskeletal-pain-a-systematic-review
#11
Jeroen Kregel, Iris Coppieters, Robby DePauw, Anneleen Malfliet, Lieven Danneels, Jo Nijs, Barbara Cagnie, Mira Meeus
BACKGROUND: Chronic musculoskeletal pain is characterized by maladaptive central neuroplastic changes. Many observational studies have demonstrated that chronic pain states are associated with brain alterations regarding structure and/or function. Rehabilitation of patients with chronic musculoskeletal pain may include cognitive, exercise, or multimodal therapies. OBJECTIVE: The current review aims to provide a constructive overview of the existing literature reporting neural correlates, based on brain magnetic resonance imaging (MRI) techniques, following conservative treatment in chronic musculoskeletal pain patients...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339273/search-for-electronic-recoil-event-rate-modulation-with-4-years-of-xenon100-data
#12
E Aprile, J Aalbers, F Agostini, M Alfonsi, F D Amaro, M Anthony, F Arneodo, P Barrow, L Baudis, B Bauermeister, M L Benabderrahmane, T Berger, P A Breur, A Brown, E Brown, S Bruenner, G Bruno, R Budnik, L Bütikofer, J Calvén, J M R Cardoso, M Cervantes, D Cichon, D Coderre, A P Colijn, J Conrad, J P Cussonneau, M P Decowski, P de Perio, P Di Gangi, A Di Giovanni, S Diglio, G Eurin, J Fei, A D Ferella, A Fieguth, D Franco, W Fulgione, A Gallo Rosso, M Galloway, F Gao, M Garbini, C Geis, L W Goetzke, Z Greene, C Grignon, C Hasterok, E Hogenbirk, R Itay, B Kaminsky, G Kessler, A Kish, H Landsman, R F Lang, D Lellouch, L Levinson, Q Lin, S Lindemann, M Lindner, J A M Lopes, A Manfredini, I Maris, T Marrodán Undagoitia, J Masbou, F V Massoli, D Masson, D Mayani, M Messina, K Micheneau, B Miguez, A Molinario, M Murra, J Naganoma, K Ni, U Oberlack, P Pakarha, B Pelssers, R Persiani, F Piastra, J Pienaar, V Pizzella, M-C Piro, G Plante, N Priel, L Rauch, S Reichard, C Reuter, A Rizzo, S Rosendahl, N Rupp, J M F Dos Santos, G Sartorelli, M Scheibelhut, S Schindler, J Schreiner, M Schumann, L Scotto Lavina, M Selvi, P Shagin, M Silva, H Simgen, M V Sivers, A Stein, D Thers, A Tiseni, G Trinchero, C Tunnell, H Wang, Y Wei, C Weinheimer, J Wulf, J Ye, Y Zhang
We report on a search for electronic recoil event rate modulation signatures in the XENON100 data accumulated over a period of 4 yr, from January 2010 to January 2014. A profile likelihood method, which incorporates the stability of the XENON100 detector and the known electronic recoil background model, is used to quantify the significance of periodicity in the time distribution of events. There is a weak modulation signature at a period of 431_{-14}^{+16} day in the low energy region of (2.0-5.8) keV in the single scatter event sample, with a global significance of 1...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28339270/publisher-s-note-first-experimental-study-of-photon-polarization-in-radiative-b_-s-0-decays-phys-rev-lett-118-021801-2017
#13
R Aaij, Anonymous
This corrects the article DOI: 10.1103/PhysRevLett.118.021801.
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28339238/publisher-s-note-search-for-structure-in-the-b_-s-0-%C3%AF-%C3%A2-invariant-mass-spectrum-phys-rev-lett-117-152003-2016
#14
R Aaij, Anonymous
This corrects the article DOI: 10.1103/PhysRevLett.117.152003.
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28339233/glue-spin-and-helicity-in-the-proton-from-lattice-qcd
#15
Yi-Bo Yang, Raza Sabbir Sufian, Andrei Alexandru, Terrence Draper, Michael J Glatzmaier, Keh-Fei Liu, Yong Zhao
We report the first lattice QCD calculation of the glue spin in the nucleon. The lattice calculation is carried out with valence overlap fermions on 2+1 flavor domain-wall fermion gauge configurations on four lattice spacings and four volumes including an ensemble with physical values for the quark masses. The glue spin S_{G} in the Coulomb gauge in the modified minimal subtraction (MS[over ¯]) scheme is obtained with one-loop perturbative matching. We find the results fairly insensitive to lattice spacing and quark masses...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28339098/quality-of-life-with-cediranib-in-relapsed-ovarian-cancer-the-icon6-phase-3-randomized-clinical-trial
#16
Dan P Stark, Adrian Cook, Julia M Brown, Michael D Brundage, Andrew C Embleton, Richard S Kaplan, Fharat A Raja, Ann Marie W Swart, Galina Velikova, Wendi Qian, Jonathan A Ledermann
BACKGROUND: The ICON6 trial showed that cediranib, an oral inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, improved clinical outcomes for patients with platinum-sensitive relapsed ovarian cancer when it was used with chemotherapy and was continued as maintenance therapy. This study describes health-related quality of life (QOL) during the first year of treatment. METHODS: Four hundred fifty-six women were randomly allocated to receive standard chemotherapy only, chemotherapy with concurrent cediranib, or chemotherapy with cediranib administered concurrently and continued as maintenance...
March 24, 2017: Cancer
https://www.readbyqxmd.com/read/28338866/the-growing-challenge-of-major-trauma-in-older-people-a-role-for-comprehensive-geriatric-assessment
#17
James Michael Fisher, Charlotte Bates, Jay Banerjee
In this commentary article, we describe the impact that an ageing population is having on the nature of major trauma seen in emergency departments. The proportion of major trauma victims who are older people is rapidly increasing and a fall from standing is now the most common mechanism of injury in major trauma. Potential barriers to effective care of this patient group are highlighted, including: a lack of consensus regarding triage criteria; potentially misleading physiological parameters within triage criteria; non-linear patient presentations and diagnostic nihilism...
March 10, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28338485/creation-of-a-regional-human-milk-assembly-a-model-to-influence-practice-and-policy-change-in-the-nicu
#18
Diane L Spatz, Amanda Evans, Elizabeth Froh
BACKGROUND: The 2011 Surgeon General's Call to Action to Support Breastfeeding highlights a need for optimizing lactation-based education for all health professionals; however, few schools of nursing and medicine offer lactation-based curriculum. In an effort to address these gaps in education and care, the director of the lactation program at a large urban children's hospital developed and instituted the annual regional Human Milk Assembly (HMA), a half-day collaborative meeting of the hospital's regional and referral hospitals' neonatal intensive care unit (NICU) nursing staff, to address lactation-based educational and training needs of all participating institutions...
March 23, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28338282/don-t-forget-to-look-down%C3%A2-%C3%A2-collaborative-approaches-to-predator-conservation
#19
Steve M Redpath, John D C Linnell, Marco Festa-Bianchet, Luigi Boitani, Nils Bunnefeld, Amy Dickman, R J Gutiérrez, R J Irvine, Maria Johansson, Aleksandra Majić, Barry J McMahon, Simon Pooley, Camilla Sandström, Annelie Sjölander-Lindqvist, Ketil Skogen, Jon E Swenson, Arie Trouwborst, Juliette Young, E J Milner-Gulland
Finding effective ways of conserving large carnivores is widely recognised as a priority in conservation. However, there is disagreement about the most effective way to do this, with some favouring top-down 'command and control' approaches and others favouring collaboration. Arguments for coercive top-down approaches have been presented elsewhere; here we present arguments for collaboration. In many parts of the developed world, flexibility of approach is built into the legislation, so that conservation objectives are balanced with other legitimate goals...
March 24, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28338153/-experience-and-present-situation-of-western-china-gastric-cancer-collaboration
#20
Jiankun Hu, Weihan Zhang, China Western China Gastric Cancer Collaboration
The Western China Gastric Cancer Collaboration (WCGCC) was founded in Chongqing, China in 2011. At the early stage of the collaboration, there were only about 20 centers. While now, there are 36 centers from western area of China, including Sichuan, Chongqing, Yunnan, Shanxi, Guizhou, Gansu, Qinghai, Xinjiang, Ningxia and Tibet. During the past few years, the WCGCC organized routinely gastric cancer standardized treatment tours, training courses of mini-invasive surgical treatment of gastric cancer and the clinical research methodology for members of the collaboration...
March 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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