keyword
https://read.qxmd.com/read/38495003/maslinic-acid-alleviates-intervertebral-disc-degeneration-by-inhibiting-the-pi3k-akt-and-nf-%C3%AE%C2%BAb-signaling-pathways
#21
JOURNAL ARTICLE
Yichen Que, Chipiu Wong, Jincheng Qiu, Wenjie Gao, Youxi Lin, Hang Zhou, Bo Gao, Pengfei Li, Zhihuai Deng, Huihong Shi, Wenjun Hu, Song Liu, Yan Peng, Peiqiang Su, Caixia Xu, Anjing Liang, Xianjian Qiu, Dongsheng Huang
Intervertebral disc degeneration (IDD) is the cause of low back pain (LBP), and recent research has suggested that inflammatory cytokines play a significant role in this process. Maslinic acid (MA), a natural compound found in olive plants ( Olea europaea ), has anti-inflammatory properties, but its potential for treating IDD is unclear. The current study aims to investigate the effects of MA on TNFα-induced IDD in vitro and in other in vivo models. Our findings suggest that MA ameliorates the imbalance of the extracellular matrix (ECM) and mitigates senescence by upregulating aggrecan and collagen II levels as well as downregulating MMP and ADAMTS levels in nucleus pulposus cells (NPCs)...
March 18, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38494975/-effect-of-ultrasonic-curettage-combined-with-sodium-hyaluronate-gel-on-chronic-periodontitis-and-its-effect-on-inflammatory-factors-hs-crp-mcp-1-and-mmp-13-in-gingival-crevicular-fluid
#22
JOURNAL ARTICLE
Fan Yang, Xu Lan, You-Hong Jin
PURPOSE: To investigate the effect of ultrasonic curettage combined with sodium hyaluronate gel in the treatment of chronic periodontitis (CP) and the effect on inflammatory factor hypersensitive C-reactive protein (hs-CRP), monocyte chemotactic protein 1 (MCP-1) and matrix metalloproteinase 13 (MMP-13) in gingival crevicular fluid. METHODS: A total of 102 patients with CP from October 2021 to October 2022 were selected, divided into experimental group (n=51) and control group (n=51) by random number table method...
December 2023: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://read.qxmd.com/read/38494897/skin-rejuvenation-through-topical-application-of-indocyanine-green-with-diffractive-optical-element-mode-of-785%C3%A2-nm-picosecond-laser-in-asian-females
#23
JOURNAL ARTICLE
Dayeon Jung, Na Reu Seung, Suk Bae Seo, Eun Joo Park, Kwang Ho Kim
BACKGROUND: Indocyanine green (ICG) exhibits robust absorption near 800 nm. AIMS: To examine the clinical effects of combining ICG with a 785 nm picosecond laser for treating photo-aged skin. PATIENT/METHODS: A 785 nm 600 picosecond laser was used on the facial area of 16 female patients with Fitzpatrick skin type III and IV (mean age: 58.44 ± 5.24 years) after applying 0.0125% ICG cream. A total of 3000 shots were administered in diffractive optical element mode at a pulse energy of 200 mJ and frequency of 10 Hz...
March 18, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38494423/loss-of-the-scavenger-receptor-marco-results-in-uncontrolled-vomocytosis-of-fungi-from-macrophages
#24
JOURNAL ARTICLE
Chinaemerem U Onyishi, Yusun Jeon, Gyorgy Fejer, Subhankar Mukhopadhyay, Siamon Gordon, Robin C May
Vomocytosis, also known as nonlytic exocytosis, is a process whereby fully phagocytosed microbes are expelled from phagocytes without discernible damage to either the phagocyte or microbe. Although this phenomenon was first described in the opportunistic fungal pathogen Cryptococcus neoformans in 2006, to date, mechanistic studies have been hampered by an inability to reliably stimulate or inhibit vomocytosis. Here we present the fortuitous discovery that macrophages lacking the scavenger receptor MAcrophage Receptor with COllagenous domain (MARCO), exhibit near-total vomocytosis of internalised cryptococci within a few hours of infection...
March 17, 2024: European Journal of Immunology
https://read.qxmd.com/read/38494335/actigraphic-sleep-patterns-are-associated-with-bone-turnover-and-bone-mineral-density-among-university-students
#25
JOURNAL ARTICLE
Megan E Petrov, Li Liu, Rekha Mudappathi, Corrie M Whisner
Poorer sleep is associated with poorer bone health among older adults but the role of sleep in bone health during younger adulthood is understudied. In this observational study, the averages and variability in total sleep time (TST), sleep efficiency (SE), and sleep midpoint of university students were examined in relation to levels of bone turnover markers (BTMs) and bone mineral density (BMD) at the lumbar spine and femur. A sample of healthy, university students (N = 59, aged 18-25 years, 51...
March 17, 2024: Journal of Sleep Research
https://read.qxmd.com/read/38494246/role-of-gene-interactions-in-the-pathophysiology-of-skeletal-dysplasias-a-case-report-in-colombia
#26
JOURNAL ARTICLE
Nathalie Yepes Madrid, Lina Johanna Moreno Giraldo
BACKGROUND: Genome association studies have shown that gene-gene interactions or epistasis play a crucial role in identifying the etiology, prognosis, and treatment response of many complex diseases beyond their main effects. Skeletal dysplasias are a heterogeneous group of congenital bone and cartilage disorders with a genetic and gen-gen interaction etiology. The current classification of skeletal dysplasias distinguishes 461 diseases in 42 groups, and the incidence of all skeletal dysplasias is more than 1 in every 5000 newborns...
March 2024: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/38494232/rational-synthesis-of-a-heparan-sulfate-saccharide-that-promotes-the-activity-of-bmp2
#27
JOURNAL ARTICLE
Karl J Shaffer, Raymond A A Smith, Alison M Daines, Xiaoman Luo, Xiaohua Lu, Tuan Chun Tan, Bach Q Le, Ralf Schwörer, Simon F R Hinkley, Peter C Tyler, Victor Nurcombe, Simon M Cool
Heparan sulfate (HS) is a glycosaminoglycan (GAG) found throughout nature and is involved in a wide range of functions including modulation of cell signalling via sequestration of growth factors. Current consensus is that the specificity of HS motifs for protein binding are individual for each protein. Given the structural complexity of HS the synthesis of libraries of these compounds to probe this is not trivial. Herein we present the synthesis of an HS decamer, the design of which was undertaken rationally from previously published data for HS binding to the growth factor BMP-2...
June 1, 2024: Carbohydrate Polymers
https://read.qxmd.com/read/38493932/vascular-study-of-decellularized-porcine-long-bones-characterization-of-a-tissue-engineering-model
#28
JOURNAL ARTICLE
R Evrard, J Manon, C Rafferty, L Fieve, O Cornu, T Kirchgesner, F E Lecouvet, T Schubert, B Lengele
INTRODUCTION: Massive bone allografts enable the reconstruction of critical bone defects in numerous conditions (e.g. tumoral, infection or trauma). Unfortunately, their biological integration remains insufficient and the reconstruction may suffer from several postoperative complications. Perfusion-decellularization emerges as a tissue engineering potential solution to enhance osseointegration. Therefore, an intrinsic vascular study of this novel tissue engineering tool becomes essential to understand its efficacy and applicability...
March 15, 2024: Bone
https://read.qxmd.com/read/38493813/a-novel-complex-coupling-agent-for-enhancing-the-compatibility-between-collagen-fiber-and-natural-rubber-a-utilization-strategy-for-leather-wastes
#29
JOURNAL ARTICLE
Xiaoyu Li, Chao Lei, Junyu Wan, Weixing Xu, Jianfei Zhou, Bi Shi
Leather shavings are generated as solid waste in the leather industry and may cause environmental pollution if not disposed judiciously. These solid wastes, primarily composed of collagen fibers (CFs), can be recycled as biomass composites. However, CFs are incompatible with natural rubber (NR) due to its hydrophilicity. Conventionally, the compatibility has been improved by utilizing silane coupling agents (SCAs) along with a large number of organic solvents, which further contribute to environmental pollution...
March 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38493717/jiagasongtang-improves-chronic-cholestasis-via-enhancing-fxr-mediated-bile-acid-metabolism
#30
JOURNAL ARTICLE
Xiaoliang He, Yingya Zhou, Jingtao Yu, Qinpo Huang, Zhengyuan Chen, Ru Xiao, Changhui Liu, Shuhua Gui, Tianqin Xiong
BACKGROUND: Bile acid (BA) enterohepatic circulation disorders are a main feature of chronic cholestatic diseases. Promoting BA metabolism is thus a potential method of improving enterohepatic circulation disorders, and treat enterohepatic inflammation, oxidative stress and fibrosis due to cholestasis. PURPOSE: To investigate the effect of JiaGaSongTang (JGST) and its blood-absorbed ingredient 6-gingerol on α-naphthylisothiocyanate (ANIT)-induced chronic cholestasis, as well as elucidate the underlying regulatory mechanism...
January 8, 2024: Phytomedicine
https://read.qxmd.com/read/38493697/pharmacological-inhibition-of-the-ace-ang-2-at1-axis-alleviates-mechanical-ventilation-induced-pulmonary-fibrosis
#31
JOURNAL ARTICLE
Jinhua Feng, Xi Huang, Qiaoyi Xu, Ri Tang, Yang Zhou, Shaojie Qin, Shunpeng Xing, Yuan Gao, Shuya Mei, Zhengyu He
Mechanical ventilation (MV) is an essential therapy for acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. However, it can also induce mechanical ventilation-induced pulmonary fibrosis (MVPF) and the underlying mechanism remains unknown. Based on a mouse model of MVPF, the present study aimed to explore the role of the angiotensin-converting enzyme/angiotensin II/angiotensin type 1 receptor (ACE/Ang-2/AT1R) axis in the process of MVPF. In addition, recombinant angiotensin-converting enzyme 2(rACE2), AT1R inhibitor valsartan, AGTR1-directed shRNA and ACE inhibitor perindopril were applied to verify the effect of inhibiting ACE/Ang-2/AT1R axis in the treatment of MVPF...
March 16, 2024: International Immunopharmacology
https://read.qxmd.com/read/38493696/l-arginine-mitigates-bleomycin-induced-pulmonary-fibrosis-in-rats-through-regulation-of-ho-1-ppar-%C3%AE-%C3%AE-catenin-axis
#32
JOURNAL ARTICLE
Nabil A Alhakamy, Abdulmohsin J Alamoudi, Hani Z Asfour, Osama A A Ahmed, Ashraf B Abdel-Naim, Esam M Aboubakr
Pulmonary fibrosis is a chronic and progressively deteriorating lung condition that can be replicated in laboratory animals by administering bleomycin, a chemotherapeutic antibiotic known for its lung fibrosis-inducing side effects. L-arginine, a semi-essential amino acid, is recognized for its diverse biological functions, including its potential to counteract fibrosis. This study aimed to evaluate the antifibrotic properties of L-arginine on bleomycin-induced pulmonary fibrosis in rats. The administration of a single intratracheal dose of bleomycin resulted in visible and microscopic damage to lung tissues, an uptick in oxidative stress markers, and an elevation in inflammatory, apoptotic, and fibrotic indicators...
March 16, 2024: International Immunopharmacology
https://read.qxmd.com/read/38493592/metabolomics-and-network-pharmacology-reveal-the-mechanism-of-antithrombotic-effect-of-asperosaponin-vi
#33
JOURNAL ARTICLE
Jin Huang, Xuewen Liang, Minrui Zhao, Yue Zhang, Ziyang Chen
Dipsaci Radix may possess antithrombotic properties, and one of its primary active ingredients is Asperosaponin VI. However, the antithrombotic effects and pharmacological mechanisms of Asperosaponin VI remain unclear. An in vivo experimental study has demonstrated the antithrombotic activity of Asperosaponin VI. Asperosaponin VI also exhibits anticoagulant properties. Asperosaponin VI significantly hindered collagen adrenergic-induced acute pulmonary thrombosis in mice and enhanced their survival rate. This hinders the formation of acute pulmonary embolisms induced by adenosine diphosphate (ADP) and decreases recovery time...
March 16, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38493137/investigation-of-the-impact-of-bromodomain-inhibition-on-cytoskeleton-stability-and-contraction
#34
JOURNAL ARTICLE
Alexander Bigger-Allen, Ali Hashemi Gheinani, Rosalyn M Adam
BACKGROUND: Injury to contractile organs such as the heart, vasculature, urinary bladder and gut can stimulate a pathological response that results in loss of normal contractility. PDGF and TGFβ are among the most well studied initiators of the injury response and have been shown to induce aberrant contraction in mechanically active cells of hollow organs including smooth muscle cells (SMC) and fibroblasts. However, the mechanisms driving contractile alterations downstream of PDGF and TGFβ in SMC and fibroblasts are incompletely understood, limiting therapeutic interventions...
March 16, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38493069/ptip-safeguards-the-epigenetic-control-of-skeletal-stem-cell-quiescence-and-potency-in-skeletogenesis
#35
JOURNAL ARTICLE
Jianfei Liang, Jing Wang, Bingdong Sui, Yibo Tong, Jihua Chai, Qin Zhou, Chenxi Zheng, Hao Wang, Liang Kong, Haojian Zhang, Yi Bai
Stem cells remain in a quiescent state for long-term maintenance and preservation of potency; this process requires fine-tuning regulatory mechanisms. In this study, we identified the epigenetic landscape along the developmental trajectory of skeletal stem cells (SSCs) in skeletogenesis governed by a key regulator, Ptip (also known as Paxip1, Pax interaction with transcription-activation domain protein-1). Our results showed that Ptip is required for maintaining the quiescence and potency of SSCs, and loss of Ptip in type II collagen (Col2)+ progenitors causes abnormal activation and differentiation of SSCs, impaired growth plate morphogenesis, and long bone dysplasia...
February 29, 2024: Science Bulletin
https://read.qxmd.com/read/38493049/lower-nkg2d-expression-in-hepatic-natural-killer-cells-predicts-poorer-prognosis-for-chronic-hepatitis-b-patients-with-cirrhosis
#36
JOURNAL ARTICLE
Yangqing Ma, Dabing Ping, Kai Huang, Yanyan Tao, Yuan Peng, Xin Sun, Chenghai Liu
OBJECTIVE: Natural killer cells (NK) acts a central player of the immune system in liver cirrhosis. The aim of this study was to examine the expression of activating intra-hepatic NK cell group 2D (NKG2D) in patients with chronic hepatitis B (CHB) and analyzed the correlation between NKG2D expression and prognosis of liver cirrhosis in these patients. METHODS: This was a cross-section study. Subjects with liver biopsy or sponge hemangioma surgery were included. The primary outcome was the NKG2D expression on intra-hepatic NK cells and their subtype cells in patients with CHB-related liver cirrhosis...
March 15, 2024: Human Immunology
https://read.qxmd.com/read/38492985/computer-assisted-image-analysis-of-preexisting-histological-patterns-of-the-cephalic-vein-to-predict-wrist-arteriovenous-fistula-non-maturation
#37
JOURNAL ARTICLE
Jeng-Wei Chen, Mao Ting, Po-Ya Chang, Chiau-Jing Jung, Chin-Hao Chang, Shi-Yu Fang, Li-Wei Liu, Kelvin Jeason Yang, Sz-Han Yu, Yih-Sharng Chen, Nai-Hsin Chi, Ron-Bin Hsu, Chih-Hsien Wang, I-Hui Wu, Hsi-Yu Yu, Chih-Yang Chan
BACKGROUND: We used computer-assisted image analysis to determine whether preexisting histological features of the cephalic vein influence the risk of non-maturation of wrist fistulas. METHODS: This study focused on patients aged 20-80 years who underwent their first wrist fistula creation. A total of 206 patients participated, and vein samples for Masson's trichrome staining were collected from 134 patients. From these, 94 patients provided a complete girth of the venous specimen for automatic image analysis...
March 15, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38492864/dexamethasone-intracanalicular-insert-for-clinically-significant-aqueous-deficient-dry-eye-a-randomized-controlled-trial
#38
JOURNAL ARTICLE
Michael Lin, Lee Guo, Ian J Saldanha, Shanna VanCourt, Julia Zeng, Sezen Karakus, Michelle Hessen, Gavin Li, Esen K Akpek
PURPOSE: To evaluate a commercially available dexamethasone intracanalicular insert to treat dry eye. DESIGN: Single-center, double-masked, randomized controlled trial. PARTICIPANTS: Patients with clinically significant aqueous-deficient dry eye [combined ocular surface staining score ≥3 (0-12), corneal fluorescein staining ≥2 (0-6), and Schirmer's wetting <10 mm at 5 minutes in both eyes] with symptoms (dryness, eye discomfort, or visual fatigue, ≥30 [0-100]) despite treatment with at least one prescription drop and deemed candidate for topical steroid...
March 14, 2024: Ophthalmology
https://read.qxmd.com/read/38492852/comprehensive-functional-characterisation-of-a-novel-ano6-variant-in-a-new-patient-with-scott-syndrome
#39
JOURNAL ARTICLE
Samantha J Montague, Joshua Price, Katherine Pennycott, Natasha J Pavey, Eleyna M Martin, Isaac Thirlwell, Samuel Kemble, Catarina Monteiro, Lily Redmond-Motteram, Natalie Lawson, Katherine Reynolds, Carl Fratter, Patricia Bignell, Anouk Groenheide, Dana Huskens, Bas de Laat, Jeremy A Pike, Natalie S Poulter, Steven G Thomas, Gillian C Lowe, Jonathan Lancashire, Paul Harrison, Neil V Morgan
BACKGROUND: Scott syndrome is a mild platelet-type bleeding disorder, first described in 1979, with only 3 unrelated families identified through defective phosphatidylserine (PS) exposure and confirmed by sequencing. The syndrome is distinguished by impaired surface exposure of procoagulant PS on platelets after stimulation. To date, platelet function and thrombin generation in this condition has not been extensively characterised. OBJECTIVES: Genetic and functional studies were undertaken in a consanguineous family with a history of excessive bleeding of unknown cause...
March 14, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38492705/succinylated-chitosan-derivative-restore-huvec-cells-function-damaged-by-tnf-%C3%AE-and-high-glucose-in-vitro-and-enhanced-wound-healing
#40
JOURNAL ARTICLE
Zhiwan Chen, Mengfei Yuan, Haojing Li, Lihua Li, Binghong Luo, Lu Lu, Qi Xiang, Shan Ding
The inflammation of chronic wounds plays a key hindering role in the wound healing process. Slowing down the inflammatory response is significant for the repair of chronic wounds. Studies have revealed that succinate can inactivate gastrin D (GSDMD) and prevent cell pyroptosis. Chitosan has anti-inflammatory properties and is commonly used as wound healing material. Therefore, we used succinic anhydride to modify chitosan and found that N-succinylated chitosan (NSC) was more effective in inhibiting inflammation...
March 14, 2024: International Journal of Biological Macromolecules
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