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https://www.readbyqxmd.com/read/29447671/label-free-and-sensitive-microrna-detection-based-on-a-target-recycling-amplification-integrated-superlong-poly-thymine-hosted-copper-nanoparticle-strategy
#1
Fengzhou Xu, Lan Luo, Hui Shi, Xiaoxiao He, Yanli Lei, Jinlu Tang, Dinggeng He, Zhenzhen Qiao, Kemin Wang
Poly(thymine)-hosted copper nanoparticles (poly T-CuNPs) have emerged as a promising label-free fluorophore for bioanalysis, but its application in RNA-related studies is still rarely explored. Herein, by utilizing duplex-specific nuclease (DSN) as a convertor to integrate target recycling mechanism into terminal deoxynucleotidyl transferase (TdT)-mediated superlong poly T-CuNPs platform, a specific and sensitive method for microRNA detection has been developed. In this strategy, a 3'-phosphorylated DNA probe can hybridize with target RNA and then be cut by DSN to produce 3'-hydroxylated fragments, which can be further tailed by TdT with superlong poly T for fluorescent CuNPs synthesis...
June 20, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29446927/gasoline-particulate-filters-as-an-effective-tool-to-reduce-particulate-and-pah-emissions-from-gdi-vehicles-a-case-study-with-two-gdi-vehicles
#2
Jiacheng Yang, Patrick Roth, Thomas D Durbin, Kent C Johnson, David R Cocker, Akua Asa-Awuku, Rasto Brezny, Michael Geller, Georgios Karavalakis
We assessed the gaseous, particulate, and genotoxic pollutants from two current technology gasoline direct injection vehicles when tested in their original configuration and with a catalyzed gasoline particulate filter (GPF). Testing was conducted over the LA92 and US06 Supplemental Federal Test Procedure (US06) driving cycles on typical California E10 fuel. The use of a GPF did not show any fuel economy and carbon dioxide (CO2) emission penalties, while the emissions of total hydrocarbons (THC), carbon monoxide (CO), and nitrogen oxides (NOx) were generally reduced...
February 15, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29443521/the-structure-and-cl-o-dissociation-energy-of-the-cloo-radical-finally-the-right-answers-for-the-right-reason
#3
Adam S Abbott, Henry F Schaefer
The chlorine peroxy radical (ClOO) has historically been a highly problematic system for theoretical studies. In particular, the erratic \textit{ab initio} predictions of the Cl--O bond length reported in the literature thus far exhibit unacceptable errors with respect to the experimental structure. In light of the widespread disagreement observed, we present a careful and systematic investigation of the ClOO geometry towards the basis set and correlation limits of single reference \textit{ab initio} theory, employing the cc-pVXZ (X = D, T, Q, 5, 6) basis sets extrapolated to the complete basis set limit and coupled cluster theory up through single, double, triple, and perturbative quadruple excitations [CCSDT(Q)]...
February 14, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29434835/the-ribosome-inhibiting-protein-riproximin-shows-antineoplastic-activity-in-experimental-pancreatic-cancer-liver-metastasis
#4
Ahmed Murtaja, Ergül Eyol, Jiang Xiaoqi, Martin R Berger, Hassan Adwan
Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognoses of all malignancy types. To improve the survival of patients with PDAC, the development of novel anticancer agents is warranted. Riproximin (Rpx) is a newly identified plant lectin, which was isolated from Ximenia americana. The ribosome inactivating protein of type II exhibits potent anticancer activity as recently demonstrated. The rat PDAC cell line ASML was used for in vitro and in vivo studies. The antiproliferative effect of Rpx was assessed using an MTT assay...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433485/safety-and-efficacy-of-platelet-rich-plasma-in-treatment-of-carpal-tunnel-syndrome-a-randomized-controlled-trial
#5
Seyed Ahmad Raeissadat, Afshin Karimzadeh, Masoud Hashemi, Leila Bagherzadeh
BACKGROUND: Carpal tunnel syndrome is the most common peripheral entrapment neuropathy, for which conservative treatments are the first measures taken. However, these measures are not usually sufficient. Recently major attention has been drawn to platelet-rich plasma for its possible effects on axon regeneration and neurological recovery. Although few studies have evaluated the effects of this treatment in carpal tunnel syndrome, further investigation is required to reach concrete conclusion...
February 13, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29430680/study-on-correlation-of-sperm-quality-parameters-with-antioxidant-and-oxidant-status-of-buffalo-bull-semen-during-various-stages-of-cryopreservation
#6
S A Lone, J K Prasad, S K Ghosh, G K Das, B Balamurugan, M R Verma
This investigation was carried out to study the correlation of sperm quality parameters with antioxidant and oxidant status of buffalo bull semen during various stages of cryopreservation. Semen samples were evaluated for sperm parameters (mass motility [MM], concentration [CON], progressive motility [PM], viability [VIB], acrosomal integrity [AI] and hypo-osmotic swelling [HOS] response), antioxidants (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx] and total antioxidant capacity [TAC]) and oxidants (Lipid peroxidation [LPO] and reactive oxygen species [ROS]) at fresh, pre-freeze and post-thaw stages...
February 11, 2018: Andrologia
https://www.readbyqxmd.com/read/29428706/oxidative-potential-of-ambient-pm2-5-in-the-coastal-cities-of-the-bohai-sea-northern-china-seasonal-variation-and-source-apportionment
#7
WeiJian Liu, YunSong Xu, WenXin Liu, QingYang Liu, ShuangYu Yu, Yang Liu, Xin Wang, Shu Tao
Emissions of air pollutants from primary and secondary sources in China are considerably higher than those in developed countries, and exposure to air pollution is main risk of public health. Identifying specific particulate matter (PM) compositions and sources are essential for policy makers to propose effective control measures for pollutant emissions. Ambient PM2.5 samples covered a whole year were collected from three coastal cities of the Bohai Sea. Oxidative potential (OP) was selected as the indicator to characterize associated PM compositions and sources most responsible for adverse impacts on human health...
February 8, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29426957/mri-of-pectoralis-major-tears-association-between-ancillary-findings-and-tear-severity
#8
Ivan R B Godoy, Edgar L Martinez-Salazar, F Joseph Simeone, Miriam A Bredella, William E Palmer, Martin Torriani
OBJECTIVE: To evaluate the significance of biceps tendon (BT) displacement and peri-bicipital hematoma on MRI in subjects with pectoralis major (PM) tears. We hypothesized that these features might be associated with tear severity at surgery. MATERIALS AND METHODS: We retrospectively identified MRI cases with PM injury and reviewed clinical, imaging, and surgical records. MR images were reviewed independently by two musculoskeletal radiologists to determine anterior displacement of BT (BT-disp, in mm) and the presence of triangular-shaped peri-bicipital hematoma...
February 9, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29423312/epidemiological-profile-of-spinal-cord-injuries-at-a-tertiary-rehabilitation-center-in-kuwait
#9
L Prasad, S Al Kandari, U Ramachandran, D Shehab, S Alghunaim
Study design: Retrospective, descriptive study. Objective: To describe the epidemiological profile of patients with spinal cord injury (SCI) in Kuwait. Setting: Physical Medicine and Rehabilitation Hospital, Kuwait. Methods: Review of medical records of 241 adult patients with SCI admitted during the period 2010-2015. The data collected included gender, age, etiology, neurological and vertebral level of injury and American Spinal Injury Association impairment scale (AIS)...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29420059/airway-management-in-athletes-wearing-lacrosse-equipment
#10
Thomas G Bowman, Richard J Boergers, Monica R Lininger
CONTEXT: Patient ventilation volume and rate have been found to be compromised due to the inability to seal a pocket mask over the chinstrap of football helmets. The effects of supraglottic airway devices such as the King LT and of lacrosse helmets on these measures have not been studied. OBJECTIVE: To assess the effects of different airway management devices and helmet conditions on producing quality ventilations while performing cardiopulmonary resuscitation on simulation manikins...
February 8, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29414364/association-patterns-for-size-fractioned-indoor-particulate-matter-and-black-carbon-and-autonomic-function-differ-between-patients-with-chronic-obstructive-pulmonary-disease-and-their-healthy-spouses
#11
Lu Pan, Wei Dong, Hongyu Li, Mark R Miller, Yahong Chen, Miranda Loh, Shaowei Wu, Junhui Xu, Xuan Yang, Masayuki Shima, Furong Deng, Xinbiao Guo
BACKGROUND: The effect of health status on the relationship between particulate matter (PM) and black carbon (BC) and cardiac autonomic function has not been examined sufficiently directly comparing patients with healthy participants. OBJECTIVES: To evaluate the association patterns between size-fractioned indoor PM and BC and cardiac autonomic function in chronic obstructive pulmonary disease (COPD) patients and their healthy spouses. METHODS: Twenty-four-hour heart rate variability (HRV) and heart rate (HR) was measured in eight pairs of stable COPD patients and their healthy spouses...
January 26, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29414008/analysis-by-lc-ms-ms-of-endogenous-steroids-from-human-serum-plasma-endometrium-and-endometriotic-tissue
#12
Merja R Häkkinen, Taija Heinosalo, Niina Saarinen, Tero Linnanen, Raimo Voutilainen, Timo Lakka, Jarmo Jääskeläinen, Matti Poutanen, Seppo Auriola
An LC-MS/MS method was developed and validated to analyze simultaneously estrogens (estradiol, E2; estrone, E1), androgens (testosterone, T; androstenedione, A4; dehydroepiandrosterone, DHEA), progestagens (17a-hydroxypregnenolone, 17OHP5; 17a-hydroxyprogesterone, 17OHP4; progesterone, P4), glucocorticoids (cortisol, F; cortisone E; corticosterone, B; 11-deoxycortisol, S; 21-hydroxyprogesterone, 21OHP4), and mineralocorticoids (aldosterone, A) from 150 μl of human serum, plasma, or endometrium and endometriotic tissue homogenates...
January 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29413120/pm-r-manuscript-reviewers
#13
(no author information available yet)
No abstract text is available yet for this article.
January 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29413119/academy-news-january-pm-r
#14
(no author information available yet)
No abstract text is available yet for this article.
January 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29407171/stpothr1-a-ndr1-hin1-like-gene-in-solanum-tuberosum-enhances-resistance-against-phytophthora-infestans
#15
Qiansi Chen, Zhendong Tian, Rui Jiang, Xueao Zheng, Conghua Xie, Jun Liu
A family of NDR1/HIN1-like (NHL) genes that shows homology to the nonrace-specific disease resistance (NDR1) and the tobacco (Nicotiana tabacum) harpin-induced (HIN1) genes is reported to be involved in defense. However, little information about NHL genes is available for the potato (Solanum tuberosum). Here, we report that the expression of StPOTHR1, a member of the NHL gene family, is associated with resistance in potato against Phytophthora infestans, and is specifically induced in inoculation sites. Overexpression of StPOTHR1 enhances resistance against P...
January 30, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29406019/community-reintegration-participation-and-employment-issues-in-veterans-and-service-members-with-traumatic-brain-injury
#16
Christina Dillahunt-Aspillaga, Gail Powell-Cope
Traumatic brain injury (TBI) has been called the signature injury of the post-9/11 wars in Iraq, Afghanistan, and neighboring countries. Although similarities exist between veterans and service members with TBI, levels of severity and different constellations of coexisting comorbid conditions affect them differently. These conditions affect physical, cognitive, and emotional function, which in turn can complicate community reintegration (CR), or the ability to return to family, vocational, and community life...
February 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29403619/national-survey-of-availability-of-physical-rehabilitation-services-in-iran-a-mixed-methods-study
#17
Marzieh Shirazikhah, Arash Mirabzadeh, Homeira Sajadi, Mohammad Taghi Joghataei, Akbar Biglarian, Tahmineh Mousavi, Farahnaz Mohammadi Shahboulaghi
Background: The prevalence of disability in Iran has increased due to ageing of the population and the presence of chronic diseases. However, little is known about the availability of rehabilitation services in Iran. Objective: To study the availability of physical rehabilitation services in Iran. Methods: This was a mixed method study. In the first phase, a qualitative design was conducted for designing an instrument with focus groups based on Service Availability and Readiness Assessment (SARA) instrument (developed by World Health Organization)...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29403607/obstacles-facing-evidence-based-medicine-in-physical-medicine-and-rehabilitation-from-opinion-and-knowledge-to-practice
#18
Seyed Ahmad Raeissadat, Mohammad Hasan Bahrami, Seyed Mansoor Rayegani, Hossein Hassanabadi, Marzieh Babaee, Sharif Najafi, Reza Aghabozorgi
Background: Evidence-based medicine (EBM) is a new approach to medicine which can guide clinical services toward effective and beneficial results with the least side effects or errors. Up to now, there have been few available articles about specialists' EBM status, specifically the status of physiatrists in the area of EBM. Objective: To determine the present status of physiatrists' attitudes, knowledge and skill in the area of EBM and the existing obstacles. Methods: The cross-sectional study was performed in 2014 among physiatrists in Iran...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29402121/john-c-carapanayiotis-1909-1999-the-greek-radiologist-and-pioneer-of-physiatry-in-greece
#19
REVIEW
Christos S S Balta, Alexia P Balanika, Olga J Carapanayiotis, Graeme Hesketh, Markos N Sgantzos
John C. Carapanayiotis was specialized in physical medicine and rehabilitation in the USA in 1948, at a time when the medical world in post-war Greece was ignorant of this specific medical specialty, and the political, economic and social backdrop was incapable of accepting and understanding the wealth of scientific knowledge that he was trying to introduce. At this point it should be noted that the specialty of Physical Medicine and Rehabilitation was established in Greece in 1973. John C. Carapanayiotis was a member of the American Congress of Physical Medicine during the 1950's...
December 2017: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/29392786/day-or-overnight-transfusion-in-critically-ill-patients-does-it-matter
#20
C Aubron, R K Kandane-Rathnayake, N Andrianopoulos, A Westbrook, S Engelbrecht, I Ozolins, M Bailey, L Murray, D J Cooper, E M Wood, Z K McQuilten
BACKGROUND AND OBJECTIVES: The timing of blood administration in critically ill patients is first driven by patients' needs. This study aimed to define the epidemiology and significance of overnight transfusion in critically ill patients. MATERIALS AND METHODS: This is a post hoc analysis of a prospective multicentre observational study including 874 critically ill patients receiving red blood cells, platelets, fresh frozen plasma (FFP) or cryoprecipitate. Characteristics of patients receiving blood only during the day (8 am up until 8 pm) were compared to those receiving blood only overnight (8 pm up until 8 am)...
February 2, 2018: Vox Sanguinis
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