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https://www.readbyqxmd.com/read/29916141/arginylated-calreticulin-increases-apoptotic-response-induced-by-bortezomib-in-glioma-cells
#1
Andrea Comba, Laura V Bonnet, Victor E Goitea, Marta E Hallak, Mauricio R Galiano
After retrotranslocation from the endoplasmic reticulum to the cytoplasm, calreticulin is modified by the enzyme arginyltransferase-1 (ATE1). Cellular levels of arginylated calreticulin (R-CRT) are regulated in part by the proteasomal system. Under various stress conditions, R-CRT becomes associated with stress granules (SGs) or reaches the plasma membrane (PM), where it participates in pro-apoptotic signaling. The mechanisms underlying the resistance of tumor cells to apoptosis induced by specific drugs remain unclear...
June 18, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29908767/a-qualitative-cross-sectional-study-of-positive-and-negative-comments-of-residency-programs-across-9-medical-and-surgical-specialties
#2
Brittany O Dulmage, Lisa Akintilo, Leah J Welty, Matthew M Davis, Maria Colavincenzo, Shuai Xu
IMPORTANCE: Residency applicants often use social media to discuss the positive and negative features of prospective training programs. An examination of the content discussed by applicants could provide guidance for how medical education faculty can better engage with prospective trainees and adapt to meet the educational expectations of a new generation of digital-native physicians. OBJECTIVE: To identify unstructured social media data submitted by residency applicants and categorize positive and negative statements to determine key themes DESIGN: Qualitative analysis of a retrospective cohort SETTING: Publically available data sets PARTICIPANTS: Anonymized medical trainees applying to residency training positions in nine specialties: dermatology, general surgery, internal medicine, obstetrics/gynecology, plastic surgery, otolaryngology, physical medicine and rehabilitation, pediatrics, and radiology from 2007 to 2017...
June 14, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29908519/dna-identification-of-human-remains-in-disaster-victim-identification-dvi-an-efficient-sampling-method-for-muscle-bone-bone-marrow-and-teeth
#3
Hans H de Boer, George J R Maat, D Aji Kadarmo, Putut T Widodo, Ate D Kloosterman, Arnoud J Kal
In disaster victim identification (DVI), DNA profiling is considered to be one of the most reliable and efficient means to identify bodies or separated body parts. This requires a post mortem DNA sample, and an ante mortem DNA sample of the presumed victim or their biological relative(s). Usually the collection of an adequate ante mortem sample is technically simple, but the acquisition of a good quality post mortem sample under unfavourable DVI circumstances is complicated due to the variable degree of preservation of the human remains and the high risk of DNA (cross) contamination...
June 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29906413/a-snap-25-cleaving-chimera-of-botulinum-neurotoxin-a-and-e-prevents-tnf%C3%AE-induced-elevation-of-the-activities-of-native-trp-channels-on-early-postnatal-rat-dorsal-root-ganglion-neurons
#4
Marc Nugent, Yamil R Yusef, Jianghui Meng, Jiafu Wang, J Oliver Dolly
Transient receptor potential (TRP) vallinoid 1 (TRPV1) and ankyrin 1 (TRPA1) are two transducing channels expressed on peripheral sensory nerves involved in pain sensation. Upregulation of their expression, stimulated by inflammatory cytokines and growth factors in animal pain models, correlate with the induction of nociceptive hyper-sensitivity. Herein, we firstly demonstrate by immuno-cytochemical labelling that TNFα augments the surface content of these channels on rat cultured dorsal root ganglion (DRG) neurons which, in turn, enhances the electrophysiological and functional responses of the latter to their specific agonists...
June 12, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29902393/administration-and-performance-on-the-spinal-cord-injury-medicine-certification-examination-over-a-10-year-period
#5
Sunil Sabharwal, Anthony E Chiodo, Mikaela M Raddatz
CONTEXT/OBJECTIVE: The examination for Spinal Cord Injury (SCI) Medicine subspecialty certification has been administered since 1998, but published information about exam performance or administration is limited. DESIGN: Retrospective review Setting/Participants: We examined de-identified information from the American Board of Physical Medicine and Rehabilitation (ABPMR) database for characteristics and performance of candidates (n = 566) who completed the SCI Medicine Examination over a 10-year period (2005-2014), during which the exam outline and passing standard remained consistent...
June 14, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29901417/application-of-multivariate-longitudinal-models-in-sirt6-fbs-and-bmi-analysis-of-the-elderly
#6
Neda Gilani, Rouhollah Haghshenas, Mahmoud Esmaeili
OBJECTIVE: SIRT6 is a main regulator of metabolism and lifespan and its importance has been implicated in the prevention against aging-related diseases. The objective of this study was to examine the application of multivariate longitudinal models in SIRT6, FBS, and BMI analysis in the elderly men after eight weeks concurrent training with supplementation of l-arginine (l-Arg). METHODS: Thirty two elderly men with mean age of 63.09 ± 3.71 years were randomly divided into four equal-sized groups (each n = 8); Exercise + supplement (ES) group; exercise + placebo (EP) group; supplement (S) group and control (C) group...
June 14, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29900976/turkish-league-against-rheumatism-consensus-report-recommendations-for-management-of-axial-spondyloarthritis
#7
Hatice Bodur, Fatma Gül Yurdakul, Şebnem Ataman, Yeşim Garip, Kemal Nas, Fikriye Figen Ayhan Fikriye Figen Ayhan, Özgür Akgül, Ayşen Akinci, Zuhal Altay, Murat Birtane, Derya Soy Buğdayci, Erhan Çapkin, Remzi Çevik, Tuncay Duruöz, Gülcan Gürer, Cahit Kaçar, Ayhan Kamanli, Ece Kaptanoğlu, Taciser Kaya, Hilal Kocabaş, Ömer Kuru, Meltem Alkan Melikoğlu, Erhan Özdemirel, Sumru Özel, Aylin Rezvani, İlhan Sezer, İsmihan Sunar, Gürkan Yilmaz
Objectives: This study aims to update 2011 Turkish League Against Rheumatism SpondyloArthritis Recommendations, and to compose a national expert opinion on management of axial spondyloArthritis under guidance of current guidelines, and implantation and dissemination of these international guidelines into our clinical practice. Patients and methods: A scientific committee of 28 experts consisting of 14 rheumatologists and 14 physical medicine and rehabilitation specialists (one of them also has an immunology PhD) was formed...
March 2018: Archives of Rheumatology
https://www.readbyqxmd.com/read/29898590/use-of-the-international-classification-of-functioning-disability-and-health-generic-30-set-for-the-characterization-of-outpatients-italian-society-of-physical-and-rehabilitative-medicine-residents-section-project
#8
Francesca Gimigliano, Alessandro De Sire, Marco Gastaldo, Irene Maghini, Marco Paoletta, Andrea Pasquini, Paolo Boldrini, Melissa Selb, Birgit Prodinger
BACKGROUND: The International Classification of Functioning, Disability and Health (ICF) Generic- 30 Set (previously referred to as Rehabilitation Set) is a minimal set of ICF categories for reporting and assessing functioning and disability in clinical populations with different health conditions along the continuum of care. Recently, the Italian Society of Physical and Rehabilitation Medicine (SIMFER) developed an Italian modification of the simple and intuitive descriptions (SID) of these categories...
June 11, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29898515/a-partial-least-squares-path-modeling-analysis-for-the-understanding-of-biodiversity-loss-in-rural-and-urban-watersheds-in-portugal
#9
L F Sanches Fernandes, A C P Fernandes, A R L Ferreira, R M V Cortes, F A L Pacheco
The main purpose of this study was to use Partial Least Squares - Path Modeling (PLS-PM) to quantify the contributions of natural and human-induced threats to biodiversity loss in rural and urban watersheds. The study area comprised the Sabor and Ave river basins, located in northern Portugal. The Sabor is rural and sparsely populated while the Ave is urbanized, industrialized and densely populated. Within PLS-PM, threats are called exogenous latent variables while the ultimate environmental consequence (biodiversity loss) is termed endogenous latent variable...
June 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29896813/cardiovascular-benefits-of-reducing-personal-exposure-to-traffic-related-noise-and-particulate-air-pollution-a-randomized-crossover-study-in-the-beijing-subway-system
#10
Xuan Yang, Xu Jia, Wei Dong, Shaowei Wu, Mark R Miller, Dayu Hu, Hongyu Li, Lu Pan, Furong Deng, Xinbiao Guo
To assess the cardiovascular benefits of protecting against particulate air pollution and noise, we conducted a randomized crossover study with 40 young healthy college students from March to May 2017 in the underground subway, Beijing. Participants each received four treatments [no intervention phase (NIP), respirator intervention phase (RIP), headphone intervention phase (HIP), respirator plus headphone intervention phase (RHIP)] in a randomized order during four different study periods with two-week washout intervals...
June 13, 2018: Indoor Air
https://www.readbyqxmd.com/read/29896377/triple-bonds-of-niobium-with-silicon-germaniun-and-tin-the-tetrylidyne-complexes-%C3%AE%C2%BA-3-tmps-co-2-nb-0000000000000000000000000000000000-0000000000000000000000000000000000-0000000000000000000000000000000000-0000000000000000000000000000000000-0000000000000000000000000000000000
#11
Alexander C Filippou, David Hoffmann, Gregor Schnakenburg
A systematic, efficient approach to first complexes containing a triple bond between niobium and the elements silicon, germanium or tin is reported. The approach involves a metathetical exchange of the niobium-centered nucleophile (NMe4 )[Nb(CO)4 (κ2 -tmps)] ( 1 ) (tmps = MeSi(CH2 PMe2 )3 ) with a suitable organotetrel(ii)halide. Compound 1 was obtained from (NMe4 )[Nb(CO)6 ] and the triphosphane tmps by photodecarbonylation. Reaction of 1 with the disilene E -Tbb(Br)Si 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 1111111111111111111111111111111111 1111111111111111111111111111111111 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 1111111111111111111111111111111111 1111111111111111111111111111111111 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 Si(Br)Tbb in the presence of 4-dimethylaminopyridine afforded selectively the red-brown silylidyne complex [(κ3 -tmps)(CO)2 Nb 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 1111111111111111111111111111111111 1111111111111111111111111111111111 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 1111111111111111111111111111111111 1111111111111111111111111111111111 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 1111111111111111111111111111111111 1111111111111111111111111111111111 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 Si-Tbb] ( 2-Si , Tbb = 4- tert -butyl-2,6-bis(bis(trimethylsilyl)methyl)phenyl)...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29893387/a-p-h-functionalized-al-p-based-frustrated-lewis-pair-hydrophosphination-of-nitriles-ring-opening-with-cyclopropenones-and-evidence-of-p-double-bond-length-as-m-dash-c-double-bond-formation
#12
Lukas Keweloh, Niklas Aders, Alexander Hepp, Damian Pleschka, Ernst-Ulrich Würthwein, Werner Uhl
Hydroalumination of R-P(H)-C[triple bond, length as m-dash]C-tBu with bulky H-Al[CH(SiMe3)2]2 afforded the new P-H functionalized Al/P-based frustrated Lewis pair R-P(H)-C[[double bond, length as m-dash]C(H)-tBu]-AlR2 [R = CH(SiMe3)2; FLP 7]. A weak adduct of 7 with benzonitrile (8) was detected by NMR spectroscopy, but could not be isolated. tert-Butyl isocyanide afforded a similar, but isolable adduct (9), in which the isocyanide C atom was coordinated to aluminium. The unique reactivity of 7 became evident from its reactions with the heteroatom substituted nitriles PhO-C[triple bond, length as m-dash]N, PhCH2S-C[triple bond, length as m-dash]N and H8C4N-C[triple bond, length as m-dash]N...
June 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29893116/dna-conjugated-amphiphilic-aggregation-induced-emission-probe-for-cancer-tissue-imaging-and-prognosis-analysis
#13
Xudong Wang, Jun Dai, Xuehong Min, Zhihua Yu, Yong Cheng, Kaixun Huang, Juliang Yang, Xiaoqing Yi, Xiaoding Lou, Fan Xia
Detection of ultralow concentration of mRNA is important in prognosis of gene related diseases. In this study, a DNA-conjugated amphiphilic aggregation-induced emission probe (TPE-R-DNA) was synthesized for cancer tissue imaging and prognosis analysis based on exonuclease III-aided target recycling technique. TPE-R-DNA comprise two components: a hydro-phobic component that serves as the "turn-on" long wavelength fluorescence imaging agent (TPE-R-N3); a hydrophilic single DNA strand (Alk-DNA) which acts as specific recognition part for target mRNA...
June 12, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29890456/preliminary-investigation-of-aircraft-mounted-thermal-imaging-to-locate-decomposing-remains-via-the-heat-produced-by-larval-aggregations
#14
Michael J Lee, Sasha C Voss, Daniel Franklin, Ian R Dadour
This study investigated the potential of aircraft mounted thermal imaging (AMTI) to locate surficial decomposing remains (clothed and unclothed) through detection of heat generated by larval aggregations of carrion feeding insects. Two trials were carried out, each utilising four pig cadavers (40-45kg) as human analogues and exposing them to insect activity in autumn and winter on the Swan Coastal Plain, Western Australia. The Western Australia Police Air Wing helicopter, fitted with a forward looking infrared radiometer (FLIR) camera, was utilised to obtain the AMTI footage of carcasses over time...
May 25, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29886681/-pollution-characteristics-and-health-risk-assessment-of-heavy-metals-in-pm-2-5-in-lanzhou
#15
Q Z Wei, S Li, Q Jia, B Luo, L M Su, Q Liu, X R Yuan, Y H Wang, Y Ruan, J P Niu
Objective: To understand the pollution characteristics and assess the pollution health risks of heavy metals in atmospheric PM(2.5) in Lanzhou. Methods: According to the regional characteristics of air pollution and industrial distribution characteristics in Lanzhou, atmospheric PM(2.5) was sampled monthly in Chengguan and Xigu Districts from January, 2015 to December, 2016. Detected the concentration of PM(2.5) and 12 kinds of elements (Sb, Al, As, Be, Cd, Cr, Hg, Pb, Mn, Ni, Se and Tl) by weighing method and inductively coupled plasma mass spectrometry...
June 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29885578/highly-selective-aptamer-based-organic-electrochemical-biosensor-with-pico-level-detection
#16
Nileshi Saraf, Eric R Woods, Madison Peppler, Sudipta Seal
An organic aptamer functionalized electrochemical transistor has been developed to detect the presence of epinephrine molecule which acts as an excitatory neurotransmitter. The abnormalities in the level of epinephrine are the direct symptoms of some diseases such as Takotsubo cardiomyopathy, myocardial infarction, arrhythmias and other heart related diseases. The present approach is based on immobilization of aptamers on the gate electrode which selectively binds to epinephrine with high affinity. The introduction of epinephrine in the system causes screening of negative charge of aptamers as well as the production of Faradaic current due to oxidation of epinephrine...
May 22, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29882792/the-e-coli-global-regulator-dksa-reduces-transcription-during-t4-infection
#17
Jennifer Patterson-West, Tamara D James, Llorenç Fernández-Coll, James R Iben, Kyung Moon, Leslie Knipling, Michael Cashel, Deborah M Hinton
Bacteriophage T4 relies on host RNA polymerase to transcribe three promoter classes: early (Pe, requires no viral factors), middle (Pm, requires early proteins MotA and AsiA), and late (Pl, requires middle proteins gp55, gp33, and gp45). Using primer extension, RNA-seq, RT-qPCR, single bursts, and a semi-automated method to document plaque size, we investigated how deletion of DksA or ppGpp, two E. coli global transcription regulators, affects T4 infection. Both ppGpp⁰ and Δ dksA increase T4 wild type (wt) plaque size...
June 6, 2018: Viruses
https://www.readbyqxmd.com/read/29879690/identifying-the-socioeconomic-determinants-of-population-exposure-to-particulate-matter-pm-2-5-in-china-using-geographically-weighted-regression-modeling
#18
Jing Chen, Chunshan Zhou, Shaojian Wang, Jincan Hu
Air pollution contributes significantly to premature death in China. However, only a limited number of studies have identified the potential determinants of population exposure to PM2.5 from a socioeconomic perspective. This paper analyses the socioeconomic determinants of population exposure at the city level in China. We first estimated population exposure to PM2.5 by integrating high resolution spatial distribution maps of PM2.5 concentrations and population density, using data for 2013. Then, geographically weighted regression (GWR) modeling was undertaken to explore the strength and direction of relationships between the selected socioeconomic factors and population exposure...
June 4, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29873752/risk-of-pressure-ulcers-in-tetraplegic-people-a-french-survey-crossing-regional-experience-with-a-long-term-follow-up
#19
Marc Le Fort, Maude Espagnacq, Thierry Albert, Chloë Lefèvre, Brigitte Perrouin-Verbe, Jean-François Ravaud
Background: Pressure ulcer risk assessment provides an indicator of quality of care in French health establishments. The reliability and validity of assessment tools have been shown to be lower for people with spinal cord injury (SCI). We hypothesized that skin complications would be less frequent in people with traumatic SCI and tetraplegia (TSCIt), who were initially managed in French regions with a high level of specialized SCI rehabilitation experience. Methods: First, we used the most recent French territorial survey about SCI to determine a 'Level of Regional Experience (LRE) in Specialized Physical Medicine and Rehabilitation'...
June 4, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29862587/the-subfornical-organ-a-novel-site-for-prolactin-action
#20
Anusha Kamesh, Emily A E Black, Alastair V Ferguson
Prolactin (PRL) is a peptide hormone which performs over 300 biological functions including those that require binding to prolactin receptor (PRL-R) in neurons within the central nervous system (CNS)1 . To enter the CNS, circulating PRL must overcome the blood-brain barrier. As such, areas of the brain that do not possess a blood-brain barrier, such as the subfornical organ (SFO), are optimally positioned to interact with systemic PRL. The SFO has been classically implicated in energy and fluid homeostasis but has the potential to influence estrous cyclicity and gonadotropin release, which are also functions of PRL2-4 ...
June 4, 2018: Journal of Neuroendocrinology
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