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https://www.readbyqxmd.com/read/28821636/twenty-four-hour-rhythmicity-of-circulating-metabolites-effect-of-body-mass-and-type-2-diabetes
#1
Cheryl M Isherwood, Daan R Van der Veen, Jonathan D Johnston, Debra J Skene
Metabolic profiling of individuals with type 2 diabetes mellitus (T2DM) has previously been limited to single-time-point samples, ignoring time-of-day variation. Here, we tested our hypothesis that body mass and T2DM affect daily rhythmicity and concentrations of circulating metabolites across a 24-h day in 3 age-matched, male groups-lean, overweight/obese (OW/OB), and OW/OB with T2DM-in controlled laboratory conditions, which were not confounded by large meals. By using targeted liquid chromatography/mass spectrometry metabolomics, we quantified 130 plasma metabolites every 2 h over 24 h, and we show that average metabolite concentrations were significantly altered by increased body mass (90 of 130) and T2DM (56 of 130)...
August 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28818820/opportunities-of-mhealth-in-preconception-care-preferences-and-experiences-of-patients-and-health-care-providers-and-other-involved-professionals
#2
Matthijs R Van Dijk, Maria Ph Koster, Ageeth N Rosman, Regine Pm Steegers-Theunissen
BACKGROUND: The importance of the preconception period and preconception care (PCC) are broadly acknowledged and the potential benefits regarding health promotion have been studied extensively. PCC provides the opportunity to identify, prevent, and treat modifiable and nonmodifiable risk factors to optimize the health of couples trying to become pregnant. The prevalence of modifiable and nonmodifiable risk factors in these couples is high, but the uptake of PCC remains low. OBJECTIVE: The aim of this study is to identify the preferences and experiences of women and men (patients) trying to become pregnant and of health care providers and other involved professionals regarding mobile health (mHealth), in particular the coaching platform Smarter Pregnancy, and its potential role in PCC...
August 17, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28818562/conduction-recovery-and-avoidance-of-permanent-pacing-after-transcatheter-aortic-valve-implantation
#3
Corinne Marzahn, Cornel Koban, Martin Seifert, Akihiro Isotani, Michael Neuß, Frank Hölschermann, Christian Butter
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is an established treatment option for patients with severe aortic stenosis and high surgical risk. Currently, various prosthesis types are available. Atrioventricular block (AVB) requiring pacemaker (PM) implantation is a typical complication after TAVI. This study investigated the recovery of AV node conduction and mid-term outcome of patients with or without PM implantation after TAVI according to prosthesis type. METHODS: From July 2008 to May 2015, 856 transcatheter heart valves were implanted at our center (age: 80...
August 14, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28810687/the-characterization-of-polycyclic-aromatic-hydrocarbons-in-northeastern-us-trucking-terminals
#4
Erica D Walker, Jaime E Hart, Eric Garshick, Jennifer M Cavallari, Mary E Davis, Thomas J Smith, Francine Laden
In recent years, significant attention has been given to polycyclic aromatic hydrocarbons (PAHs) exposures given their mutagenic and carcinogenic properties. However, levels of exposure and the key determinants of exposure are not well defined for the trucking industry. We measured ultrafine particle characteristics at 10 trucking terminals of varying operating size and location in the Northeast region of the United States using particle concentration counter and a surface area analyzer. Multivariate mixed-effects linear regression models were used to assess determinants of the concentration of total bound PAHs (tPAH), the total aerosol active surface area (AS), and the ratio tPAH/AS overall and individually within docks, trucking cabs, and administrative offices...
August 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28800689/evaluation-of-edar-vehicle-emissions-remote-sensing-technology
#5
Karl Ropkins, Timothy H DeFries, Francis Pope, David C Green, Jim Kemper, Sandeep Kishan, Gary W Fuller, Hu Li, Jim Sidebottom, Leigh R Crilley, Louisa Kramer, William J Bloss, J Stewart Hager
Despite much work in recent years, vehicle emissions remain a significant contributor in many areas where air quality standards are under threat. Policy-makers are actively exploring options for next generation vehicle emission control and local fleet management policies, and new monitoring technologies to aid these activities. Therefore, we report here on findings from two separate but complementary blind evaluation studies of one new-to-market real-world monitoring option, HEAT LLC's Emission Detection And Reporting system or EDAR, an above-road open path instrument that uses Differential Absorption LIDAR to provide a highly sensitive and selective measure of passing vehicle emissions...
August 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28796505/toolbox-of-nonmetallocene-lanthanides-multifunctional-catalysts-in-group-transfer-polymerization
#6
Friederike Adams, Martin R Machat, Peter T Altenbuchner, Johannes Ehrmaier, Alexander Pöthig, Tolga N V Karsili, Bernhard Rieger
Herein, we present a fundamental study of isostructural 2-methoxyethylamino-bis(phenolate)-lanthanide complexes [(ONOO)(R)M(X)(THF)] (M = Lu, Y; R = (t)Bu, CMe2Ph, X = CH2TMS, collidine; THF = tetrahydrofuran; TMS = trimethylsilyl) for rare-earth metal-mediated group-transfer polymerization (GTP). This analysis includes the differentiation of electron-donating and nondonating vinyl monomers and two metal centers with regard to the ionic radius (yttrium and lutetium). In addition, highly nucleophilic alkyl initiators are compared with electron-donating heteroaromatic initiators...
August 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28795562/axially-bound-ruthenium-phthalocyanine-monolayers-on-indium-tin-oxide-structure-energetics-and-charge-transfer-properties
#7
Ramanan Ehamparam, Luis E Oquendo, Michael W Liao, Ambjorn Karl Brynnel, Kai-Lin Ou, Neal R Armstrong, Dominic V McGrath, S Scott Saavedra
The efficiency of charge collection at the organic/transparent conducting oxide (TCO) interface in organic photovoltaic (OPV) devices affects overall device efficiency. Modifying the TCO with an electrochemically active molecule may enhance OPV efficiency by providing a charge-transfer pathway between the electrode and the organic active layer, and may also mitigate surface recombination. The synthesis and characterization of phosphonic acid-ruthenium phthalocyanine (RuPcPA) monolayer films on indium tin oxide (ITO), designed to facilitate charge harvesting at ITO electrodes, is presented in this work...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28793987/testing-the-direction-of-effects-between-child-body-composition-and-restrictive-feeding-practices-results-from-a-population-based-cohort
#8
Ivonne Pm Derks, Henning Tiemeier, Eric Jg Sijbrands, Jan M Nicholson, Trudy Voortman, Frank C Verhulst, Vincent Wv Jaddoe, Pauline W Jansen
Background: Parental restrictive feeding (i.e., limiting food intake of children) has been linked to childhood overweight. However, the directionality of the causal pathway remains unknown.Objective: The objectives of this study were to examine the bidirectional association of maternal restrictive feeding with children's weight and body composition across childhood and to explore a possible mediating role of maternal concern about child weight.Design: Data were available for 4689 mother-child dyads participating in Generation R, a prospective birth cohort in the Netherlands...
August 9, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28790540/the-effect-of-adolescent-idiopathic-scoliosis-on-the-occurrence-of-varicose-veins-on-lower-extremities
#9
Goran Talic, Luka Talic, Djurdjica Stevanovic-Papica, Tatjana Nozica-Radulovic, Snjezana Novakovic-Bursac
INTRODUCTION: Scoliosis is a complex three-dimensional spine deformity with the frontal plane deflexion (side-shift) of the series of vertebra from the midline and with torque deformity of vertebra, ribs, and the entire trunk towards the apex of curve. Chronic venous diseases present a group of pathological conditions caused by the increased venous pressure. The venous pressure may be increased due to genetics, ligament laxity, general obesity, injuries, and changes in biomechanics of spine and lower extremities, etc...
April 2017: Medical Archives
https://www.readbyqxmd.com/read/28783065/assessing-the-utility-of-low-cost-particulate-matter-sensors-over-a-12-week-period-in-the-cuyama-valley-of-california
#10
Anondo Mukherjee, Levi G Stanton, Ashley R Graham, Paul T Roberts
The use of low-cost air quality sensors has proliferated among non-profits and citizen scientists, due to their portability, affordability, and ease of use. Researchers are examining the sensors for their potential use in a wide range of applications, including the examination of the spatial and temporal variability of particulate matter (PM). However, few studies have quantified the performance (e.g., accuracy, precision, and reliability) of the sensors under real-world conditions. This study examined the performance of two models of PM sensors, the AirBeam and the Alphasense Optical Particle Counter (OPC-N2), over a 12-week period in the Cuyama Valley of California, where PM concentrations are impacted by wind-blown dust events and regional transport...
August 5, 2017: Sensors
https://www.readbyqxmd.com/read/28782539/leveraging-the-medical-context-to-increase-upper-extremity-reconstruction-among-patients-with-tetraplegia-a-qualitative-analysis
#11
Chelsea A Harris, John-Michael Muller, Melissa J Shauver, Kevin C Chung
OBJECTIVES: (1) To characterize patients' medical experiences from initial injury until they become candidates for Upper Extremity Reconstruction (UER). (2) To identify points in this medical context that may be most amenable to interventions designed to increase UER utilization. DESIGN: A qualitative cross-sectional study using grounded theory methodology and constant comparative analysis of data collected through semi-structured individual interviews. SETTING: Community PARTICIPANTS: A sample of individuals with C4-C8 cervical spinal injuries (N=19) who sustained injuries at least one year prior to interview...
August 3, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28782457/prospective-memory-in-youth-with-perinatally-acquired-hiv-infection
#12
Lynnette L Harris, Miriam C Chernoff, Sharon L Nichols, Paige L Williams, Patricia A Garvie, Cenk Yildirim, Stephen R McCauley, Steven Paul Woods
Youth with perinatal HIV infection (PHIV) are at increased risk for neurocognitive impairment (NCI). Prospective memory (PM) is a complex neurocognitive function that has been shown to be impaired in adults with HIV disease and independently associated with poorer daily living skills, including medication nonadherence. The current study sought to determine the presence and extent of PM deficits in youth with PHIV. Participants included 173 youth with PHIV and 85 youth perinatally HIV-exposed but uninfected (PHEU), mean age 14...
August 7, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28780160/macrocyclic-factor-xia-inhibitors
#13
Cailan Wang, James R Corte, Karen A Rossi, Jeffrey M Bozarth, Yiming Wu, Steven Sheriff, Joseph E Myers, Joseph M Luettgen, Dietmar A Seiffert, Ruth R Wexler, Mimi L Quan
A series of macrocyclic factor XIa (FXIa) inhibitors was designed based on an analysis of the crystal structures of the acyclic phenylimidazole compounds. Further optimization using structure-based design led to inhibitors with pM affinity for FXIa, excellent selectivity against a panel of relevant serine proteases, and good potency in the activated partial thromboplastin time (aPTT) clotting assay.
July 25, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28777977/relationship-between-reactive-oxygen-species-and-water-soluble-organic-compounds-time-resolved-benzene-carboxylic-acids-measurement-in-the-coastal-area-during-the-korus-aq-campaign
#14
Min-Suk Bae, James J Schauer, Taehyoung Lee, Ju-Hee Jeong, Yoo-Keun Kim, Chul-Un Ro, Sang-Keun Song, Zang-Ho Shon
This study investigated the relationship between water-soluble organic compounds of ambient particulate matter (PM) and cellular redox activity collected from May 28 to June 20 of 2016 at the west coastal site in the Republic of Korea during the KORea-US Air Quality (KORUS-AQ) campaign. Automatic four-hour integrated samples operated at a flow rate of 92 L per minute for the analysis of organic carbon (OC), water-soluble organic carbon (WSOC), elemental carbon (EC), water-soluble ions (WSIs), and benzene carboxylic acids (BCAs) were collected on a 47 mm quartz fiber filter...
August 1, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28774027/suitability-of-secondary-peek-telescopic-crowns-on-zirconia-primary-crowns-the-influence-of-fabrication-method-and-taper
#15
Susanne Merk, Christina Wagner, Veronika Stock, Marlis Eichberger, Patrick R Schmidlin, Malgorzata Roos, Bogna Stawarczyk
This study investigates the retention load (RL) between ZrO₂ primary crowns and secondary polyetheretherketone (PEEK) crowns made by different fabrication methods with three different tapers. Standardized primary ZrO₂ crowns were fabricated with three different tapers: 0°, 1°, and 2° (n = 10/group). Ten secondary crowns were fabricated (i) milled from breCam BioHPP blanks (PM); (ii) pressed from industrially fabricated PEEK pellets (PP) (BioHPP Pellet); or (iii) pressed from granular PEEK (PG) (BioHPP Granulat)...
November 8, 2016: Materials
https://www.readbyqxmd.com/read/28770473/vegf-and-vegfr1-levels-in-different-regions-of-the-normal-and-preeclampsia-placentae
#16
Akriti S Sahay, Anjali T Jadhav, Deepali P Sundrani, Girija N Wagh, Savita S Mehendale, Preeti Chavan-Gautam, Sadhana R Joshi
Altered placental angiogenesis is implicated in the pathophysiology of preeclampsia. We have earlier reported placental regional differences in oxidative stress markers and neurotrophins. Oxidative stress and neurotrophins are reported to regulate angiogenesis. This study aims to examine protein and mRNA levels of vascular endothelial growth factor (VEGF) and VEGF receptor 1 (VEGFR1) in four regions [central maternal (CM), central fetal (CF), peripheral maternal (PM), and peripheral fetal (PF)] of the placenta in normotensive control (NC) women (n = 51) and women with preeclampsia (PE) (n = 43) [18 delivered at term (T-PE) and 25 delivered preterm (PT-PE)]...
August 2, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28765077/resolution-of-vascular-injury-specialized-lipid-mediators-and-their-evolving-therapeutic-implications
#17
REVIEW
Bian Wu, Giorgio Mottola, Melinda Schaller, Gilbert R Upchurch, Michael S Conte
Acute vascular injury occurs in a number of important clinical contexts, including spontaneous disease-related events (e.g. plaque rupture, thrombosis) and therapeutic interventions such as angioplasty, stenting, or bypass surgery. Endothelial cell (EC) disruption exposes the underlying matrix, leading to a rapid deposition of platelets, coagulation proteins, and leukocytes. A thrombo-inflammatory response ensues characterized by leukocyte recruitment, vascular smooth muscle cell (VSMC) activation, and the elaboration of cytokines, reactive oxygen species and growth factors within the vessel wall...
August 3, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28763614/development-of-novel-peptide-based-michael-acceptors-targeting-rhodesain-and-falcipain-2-for-the-treatment-of-neglected-tropical-diseases-ntds
#18
Santo Preveti, Roberta Ettari, Sandro Cosconati, Giorgio Amendola, Khawla Chouchene, Annika Wagner, Ute A Hellmich, Kathrin Ulrich, R Luise Krauth-Siegel, Peter R Wich, Ira Schmid, Tanja Schirmeister, Jiri Gut, Philip J Rosenthal, Silvana Grasso, Maria Zappalà
This paper describes the development of a class of peptide-based inhibitors as novel antitrypanosomal and antimalarial agents. The inhibitors are based on a characteristic peptide-sequence for the inhibition of the cysteine proteases rhodesain of T. b. rhodesiense and falcipain-2 of P. falciparum. We exploited the reactivity of novel unsaturated electrophilic functions such as vinyl-sulfones, -ketones, -esters and -nitriles. The Michael acceptors inhibited both rhodesain and falcipain-2, at nanomolar and micromolar level, respectively...
August 1, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28762370/impact-of-cyp2d6-polymorphisms-on-endoxifen-concentrations-and-breast-cancer-outcomes
#19
REVIEW
G S Hwang, R Bhat, R D Crutchley, M V Trivedi
We investigated the impact of germline CYP2D6 genotyping done using the non-tumor specimen on endoxifen concentrations and/or clinical outcomes in breast cancer (BC) patients treated with tamoxifen in published studies. We evaluated published data from 13 001 patients in 29 studies. Mean±s.d. endoxifen concentrations were significantly lower in poor metabolizers (PM) versus extensive metabolizers (EM) (8.8±7.2 versus 22.3±11.8 ng ml(-1); P<0.05). The PM status did not influence clinical outcomes in majority of the studies...
August 1, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28759831/pulsed-uv-laser-induced-modifications-in-optical-and-structural-characteristics-of-alpha-irradiated-pm-355-ssntd
#20
S S Alghamdi, W A Farooq, M R Baig, M S Algarawi, Talal Mohammed Alrashidi, Syed Mansoor Ali, K Alfaramawi
Pre- and postalpha-exposed PM-355 detectors were irradiated using UV laser with different number of pulses (100, 150, 200, 300, and 400). UV laser beam energy of 20mJ per pulse with a pulse width of 9ns was incident on an area of 19.6mm(2) of the samples. XRD spectra indicated that for both reference and UV-irradiated samples, the structure is amorphous, but the crystallite size increases upon UV irradiation. The same results were obtained from SEM analysis. Optical properties of PM-355 polymeric solid-state nuclear track detectors were also investigated...
July 8, 2017: Applied Radiation and Isotopes
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