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https://www.readbyqxmd.com/read/29044495/urban-particulate-matter-stimulation-of-human-dendritic-cells-enhances-priming-of-na%C3%A3-ve-cd8-t-lymphocytes
#1
Paul E Pfeffer, Tzer R Ho, Elizabeth H Mann, Frank J Kelly, Maria Sehlstedt, Jamshid Pourazar, Rosamund E Dove, Thomas Sandstrom, Ian S Mudway, Catherine M Hawrylowicz
Epidemiological studies have consistently shown associations between elevated concentrations of urban particulate matter (UPM) air pollution and exacerbations of asthma and COPD, which are both associated with viral respiratory infections. The effects of urban PM on dendritic cell (DC) stimulated CD4 T lymphocytes have been investigated previously, however little work has focused on CD8 T lymphocyte responses despite their importance in anti-viral immunity. To address this, we examined the effects of UPM on DC-stimulated naïve CD8 T cell responses...
October 16, 2017: Immunology
https://www.readbyqxmd.com/read/29043979/warm-cozy-woodstoves-%C3%A2-%C3%A2-%C3%A2-and-the-pm-they-produce-home-interventions-show-mixed-results-in-protecting-children-with-asthma
#2
Julia R Barrett
No abstract text is available yet for this article.
October 17, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29039736/a-novel-central-nervous-system-penetrating-protease-inhibitor-overcomes-human-immunodeficiency-virus-1-resistance-with-unprecedented-am-to-pm-potency
#3
Manabu Aoki, Hironori Hayashi, Kalapala Venkateswara Rao, Debananda Das, Nobuyo Higashi-Kuwata, Haydar Bulut, Hiromi Aoki-Ogata, Yuki Takamatsu, Ravikiran S Yedidi, David A Davis, Shin-Ichiro Hattori, Noriko Nishida, Kazuya Hasegawa, Nobutoki Takamune, Prasanth R Nyalapatla, Heather L Osswald, Hirofumi Jono, Hideyuki Saito, Robert Yarchoan, Shogo Misumi, Arun K Ghosh, Hiroaki Mitsuya
Antiretroviral therapy for HIV-1 infection/AIDS has significantly extended the life expectancy of HIV-1-infected individuals and reduced HIV-1 transmission at very high rates. However, certain individuals who initially achieve viral suppression to undetectable levels may eventually suffer treatment failure mainly due to adverse effects and the emergence of drug-resistant HIV-1 variants. Here, we report GRL-142, a novel HIV-1 protease inhibitor containing an unprecedented 6-5-5-ring-fused crown-like tetrahydropyranofuran, which has extremely potent activity against all HIV-1 strains examined with IC50 values of attomolar-to-picomolar concentrations, virtually no effects on cellular growth, extremely high genetic barrier against the emergence of drug-resistant variants, and favorable intracellular and central nervous system penetration...
October 17, 2017: ELife
https://www.readbyqxmd.com/read/29038987/development-and-optimization-of-a-starch-based-co-processed-excipient-for-direct-compression-using-mixture-design
#4
Yonni E Apeji, Avosuahi R Oyi, Adamu B Isah, Teryila S Allagh, Sameer R Modi, Arvind K Bansal
The development of novel excipients with enhanced functionality has been explored using particle engineering by co-processing. The aim of this study was to improve the functionality of tapioca starch (TS) for direct compression by co-processing with gelatin (GEL) and colloidal silicon dioxide (CSD) in optimized proportions. Design of Experiment (DoE) was employed to optimize the composition of the co-processed excipient using the desirability function and other supporting studies as a basis for selecting the optimized formulation...
October 16, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29031349/aging-with-grace-dignity-and-courage-a-mission-for-physical-medicine-and-rehabilitation
#5
EDITORIAL
Santos F Martinez
No abstract text is available yet for this article.
November 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29031214/land-use-regression-models-for-the-oxidative-potential-of-fine-particles-pm2-5-in-five-european-areas
#6
John Gulliver, David Morley, Chrissi Dunster, Adrienne McCrea, Erik van Nunen, Ming-Yi Tsai, Nicoltae Probst-Hensch, Marloes Eeftens, Medea Imboden, Regina Ducret-Stich, Alessio Naccarati, Claudia Galassi, Andrea Ranzi, Mark Nieuwenhuijsen, Ariadna Curto, David Donaire-Gonzalez, Marta Cirach, Roel Vermeulen, Paolo Vineis, Gerard Hoek, Frank J Kelly
Oxidative potential (OP) of particulate matter (PM) is proposed as a biologically-relevant exposure metric for studies of air pollution and health. We aimed to evaluate the spatial variability of the OP of measured PM2.5 using ascorbate (AA) and (reduced) glutathione (GSH), and develop land use regression (LUR) models to explain this spatial variability. We estimated annual average values (m(-3)) of OP(AA) and OP(GSH) for five areas (Basel, CH; Catalonia, ES; London-Oxford, UK (no OP(GSH)); the Netherlands; and Turin, IT) using PM2...
October 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/29024755/performance-of-pediatric-rehabilitation-medicine-candidates-on-the-subspecialty-board-certification-examination-from-2003-2015
#7
Sherilyn W Driscoll, Teresa L Massagli, Mary A McMahon, Mikaela M Raddatz, David W Pruitt, Kevin P Murphy
BACKGROUND: Pediatric Rehabilitation Medicine (PRM) physicians enter the field via several pathways. It is unknown if different training pathways impact performance on the American Board of Physical Medicine and Rehabilitation (ABPMR) PRM Examination and Maintenance of Certification (MOC) Examination. OBJECTIVES: To describe the exam performance of candidates on the ABPMR PRM Examination according to their type of training (physiatrists with a clinical PRM focus, accredited or unaccredited fellowship training, separate pediatric and PM&R residencies or combined Peds/PM&R residencies) and to compare candidates' performance on the PRM Examination with their initial ABPMR certification and MOC Examinations...
October 9, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29018639/managing-heart-failure-at-home-with-point-of-care-diagnostics
#8
Paul R Degregory, Jansen Tapia, Tammy Wong, Jo Villa, Ian Richards, Richard M Crooks
The objective of this paper is development of an inexpensive point-of-care sensor for detecting the primary heart failure marker peptide, NT-proBNP. The device technology is based on an antibody sandwich assay, but with three innovative aspects. First, chemical amplification is carried out via oxidation of silver nanoparticles (NPs) attached to signaling antibodies rather than by enzymatic amplification. The electrochemical method is faster and eliminates the need for long-term storage of enzymes. Second, the antibody sandwich is formed on mobile magnetic beads...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29017987/nanomaterials-versus-ambient-ultrafine-particles-an-opportunity-to-exchange-toxicology-knowledge
#9
REVIEW
Vicki Stone, Mark R Miller, Martin J D Clift, Alison Elder, Nicholas L Mills, Peter Møller, Roel P F Schins, Ulla Vogel, Wolfgang G Kreyling, Keld Alstrup Jensen, Thomas A J Kuhlbusch, Per E Schwarze, Peter Hoet, Antonio Pietroiusti, Andrea De Vizcaya-Ruiz, Armelle Baeza-Squiban, João Paulo Teixeira, C Lang Tran, Flemming R Cassee
BACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis...
October 10, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28991813/using-discrete-event-simulation-to-promote-quality-improvement-and-efficiency-in-a-radiation-oncology-treatment-center
#10
Robin M Famiglietti, Emily C Norboge, Valentine Boving, James R Langabeer, Thomas A Buchholz, Osama Mikhail
BACKGROUND: To meet demand for radiation oncology services and ensure patient-centered safe care, management in an academic radiation oncology department initiated quality improvement efforts using discrete-event simulation (DES). Although the long-term goal was testing and deploying solutions, the primary aim at the outset was characterizing and validating a computer simulation model of existing operations to identify targets for improvement. METHODS: The adoption and validation of a DES model of processes and procedures affecting patient flow and satisfaction, employee experience, and efficiency were undertaken in 2012-2013...
October 2017: Quality Management in Health Care
https://www.readbyqxmd.com/read/28988103/opioid-tapering-in-patients-with-prescription-opioid-use-disorder-a-retrospective-study
#11
Kehua Zhou, Peng Jia, Swati Bhargava, Yong Zhang, Taslima Reza, Yuan Bo Peng, Gary G Wang
BACKGROUND AND AIMS: Opioid use disorder (OUD) refers to a maladaptive pattern of opioid use leading to clinically significant impairment or distress. OUD causes, and vice versa, misuses and abuse of opioid medications. Clinicians face daily challenges to treat patients with prescription opioid use disorder. An evidence-based management for people who are already addicted to opioids has been identified as the national priority in the US; however, options are limited in clinical practices...
October 4, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28987902/comparison-of-ultrasonography-and-short-segment-nerve-conduction-study-in-ulnar-neuropathy-at-the-elbow
#12
Rana Terlemez, Figen Yilmaz, Beril Dogu, Banu Kuran
OBJECTIVE: We aimed to assess the correlation between ultrasonographic and electrodiagnostic findings to determine the localization of the ulnar trapping at the elbow. DESIGN AND SETTING: A cross-sectional and non-interventional trial was conducted in patients diagnosed as ulnar nerve entrapment in physical medicine and rehabilitation department of a teaching hospital. PARTICIPANTS: Between January 2017 and April 2017, 14 patients diagnosed as ulnar nerve entrapment (UNE) with short segment nerve conduction study were enrolled...
October 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28984328/nmr-effective-radius-of-hydrogen-in-xiv-group-hydrides-evaluated-by-nmr-spectroscopy
#13
M Benedetti, F De Castro, A Ciccarese, F P Fanizzi
In the [ABrnIm] (A = C, Si, Ge, Sn; n + m = 4) compounds, with the heavier halides bonded to the central IV group elements, the experimental (13)C, (29)Si, (73)Ge and (119)Sn NMR chemical shifts of the central atoms were found to be strictly linearly proportional to the bonded halides ionic radii overall sum ∑(rh). Based on this, calibration lines relating the chemical shifts to ∑(rh) could be built for the considered subgroup of [ABrnIm] compounds. Using such calibration lines we could calculate the equivalent NMR radius, (NMR)rH-A, attributable to each of the bonded hydrogens in [AH4] species, according to the overall NMR shielding produced on the central A atom...
October 6, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28980008/challenges-and-barriers-for-implementation-of-the-world-health-organization-global-disability-action-plan-in-low-and-middle-income-countries
#14
Fary Khan, Mayowa Ojo Owolabi, Bhasker Amatya, Talhatu Kolapo Hamzat, Adesola Ogunniyi, Helen Oshinowo, Alaeldin Elmalik, Mary P Galea
OBJECTIVE: To identify potential barriers and facilitators for implementation of the World Health Organization Global Disability Action Plan (GDAP) in Nigeria and compare these with other low- and middle-income countries. METHODS: A rehabilitation team from the Royal Melbourne Hospital, Parkville, Australia, conducted intensive workshops at medical/academic institutions in Nigeria for healthcare professionals from various local Physical Medicine and Rehabilitation facilities...
October 5, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28978583/management-and-patients-perspective-regarding-a-common-peroneal-nerve-schwannoma-a-rare-cause-of-lower-leg-pain-in-a-young-individual
#15
Aniek Pm van Zantvoort, Paul Cuppen, Marc R Scheltinga
The differential diagnosis of exercise-induced lower leg pain in young individuals is extensive and includes entities such as chronic exertional compartment syndrome, popliteal arterial entrapment syndrome, cystic adventitial disease, medial tibial stress syndrome and tibial stress fractures. Peripheral nerve-related lower leg pain syndromes are unusual. We present a 41-year-old woman who was diagnosed with an ancient schwannoma of the right common peroneal nerve (CPN) as a rare cause of lower leg pain. This case report provides simple diagnostic bedside tools that may be used to diagnose CPN abnormalities...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28974480/plasma-concentrations-of-per-and-polyfluoroalkyl-substances-at-baseline-and-associations-with-glycemic-indicators-and-diabetes-incidence-among-high-risk-adults-in-the-diabetes-prevention-program-trial
#16
RANDOMIZED CONTROLLED TRIAL
Andres Cardenas, Diane R Gold, Russ Hauser, Ken P Kleinman, Marie-France Hivert, Antonia M Calafat, Xiaoyun Ye, Thomas F Webster, Edward S Horton, Emily Oken
BACKGROUND: Several per- and polyfluoroalkyl substances (PFAS) are ubiquitous anthropogenic pollutants almost universally detected in humans. Experimental evidence indicates that PFAS alter glucose metabolism and insulin secretion. However, epidemiological studies have yielded inconsistent results. OBJECTIVE: We sought to examine associations between plasma PFAS concentrations, glycemic indicators, and diabetes incidence among high-risk adults. METHODS: Within the Diabetes Prevention Program (DPP), a trial for the prevention of type 2 diabetes among high-risk individuals, we quantified baseline plasma concentrations of nine PFAS among 957 participants randomized to a lifestyle intervention or placebo...
October 2, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28964447/scale-linking-to-enable-patient-reported-outcome-performance-measures-assessed-with-different-patient-reported-outcome-measures
#17
MULTICENTER STUDY
Irene L Katzan, Youran Fan, Sandra D Griffith, Paul K Crane, Nicolas R Thompson, David Cella
BACKGROUND: Patient-reported outcome performance measures (PRO-PMs) incorporate outcomes from the patient's perspective into performance measures and may have great potential to impact health care. The various patient-reported outcome measures (PROMs) used to assess the same outcome challenge widespread use of PRO-PMs. A potential solution is to statistically link PROMs to provide equivalent PRO-PM conclusions to be drawn regardless of which PROM was used. OBJECTIVES: To determine the level of agreement in the performance of two depression-related PRO-PMs assessed using the nine-item Patient Health Questionnaire (PHQ-9) depression scale and the eight-item Patient-Reported Outcomes Measurement Information System (PROMIS) Depression short form and the PHQ-9 cocalibrated on the PROMIS metric...
September 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28961223/a-light-up-probe-for-detection-of-adenosine-in-urine-samples-by-a-combination-of-an-aie-molecule-and-an-aptamer
#18
Yingying Hu, Jingjing Liu, Xiangyu You, Can Wang, Zhen Li, Weihong Xie
A light-up fluorescent probe for the detection of adenosine was constructed with an AIE (aggregation-induced emission) molecule and a DNA aptamer. The AIE molecule was used as a signal generator, and the DNA aptamer was used as a recognition element for adenosine. The emission of the AIE molecule was due to its intramolecular rotation restriction induced by the aptamer upon binding of adenosine. The optimal component ratio of the probe was AIE molecule / DNA aptamer = 100 (μM/μM). The calibration curve of adenosine detection showed a linear range of 10 pM to 0...
September 29, 2017: Sensors
https://www.readbyqxmd.com/read/28957251/cw-to-pulse-conversion-using-temporal-talbot-array-illuminators
#19
Carlos R Fernández-Pousa, Reza Maram, José Azaña
We report on the linear conversion of continuous-wave (CW) laser light to optical pulses using temporal Talbot array illuminators (TAIs) with fractional orders 1/q(q≤10), implemented by use of multilevel PM and dispersive propagation in a chirped fiber Bragg grating. The generated, sub-nanosecond optical pulse trains have repetition rates in the gigahertz range and show the presence of satellite pulses originated by the finite electrical modulation bandwidth (7.5 GHz). Though this fact impacts the resulting extinction ratio, an experimental comparison with time and Fresnel lenses indicates that temporal TAIs represent compact systems with high light gathering efficiency (>87%) at moderate values of compression (q≤8), which can be tailored in repetition rate, gain, or width, through the fractional Talbot order for its use in pulse compression systems fed by CW light...
July 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28957116/observations-from-direct-uv-written-non-hydrogen-loaded-thermally-regenerated-bragg-gratings-in-double-clad-photosensitive-fiber
#20
Alexander Jantzen, Rex H S Bannerman, Sam A Berry, James C Gates, Paul C Gow, Lewis J Boyd, Peter G R Smith, Christopher Holmes
In this Letter, experimental evidence is provided for an enhanced thermal sensitivity for a double thermal regeneration feature in fiber Bragg gratings fabricated by direct ultraviolet (UV) writing. Here 47 gratings of varying fluence and wavelength were written along a double-clad, germanium-doped core fiber. Subsequently thermal processing without hydrogen loading the fiber was performed and thermal treatment was carried out in a pure oxygen environment. Thermal sensitivity for the double regeneration increased from 13...
October 1, 2017: Optics Letters
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