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https://www.readbyqxmd.com/read/29225162/can-ultrasound-be-used-to-improve-the-palpation-skills-of-physicians-in-training-a-prospective-study
#1
Ryan Woods, Steve J Wisniewski, Daniel R Lueders, Thomas P Pittelkow, Dirk R Larson, Jonathan T Finnoff
BACKGROUND: Accurate diagnosis of musculoskeletal disorders relies heavily upon the physical examination, including accurate palpation of musculoskeletal structures. The literature has suggested there has been deterioration of physical examination skills among medical students and residents in part due to increased reliance on advanced imaging. It has been shown that knowledge of musculoskeletal anatomy and physical examination skills improve with the use of ultrasound; however, the literature is limited...
December 7, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29223078/impact-on-mortality-of-biomass-combustion-from-wildfires-in-spain-a-regional-analysis
#2
C Linares, R Carmona, P Salvador, J Díaz
Studies that analyse the impact on mortality of particulate matter (PM) produced by biomass combustion from wildfires mostly focus on a single city or on cities in different countries, with very few concentrating on one country as a whole. Accordingly, the aim of this paper was to analyse the impact that PM has on daily mortality in Spain on days with biomass combustion from wildfires. To analyse natural PM advections the Ministry of Agriculture and Fishing, Food & Environment divides Spain into 9 geographical regions...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29219103/climate-change-impacts-on-human-health-over-europe-through-its-effect-on-air-quality
#3
REVIEW
Ruth M Doherty, Mathew R Heal, Fiona M O'Connor
This review examines the current literature on the effects of future emissions and climate change on particulate matter (PM) and O3 air quality and on the consequent health impacts, with a focus on Europe. There is considerable literature on the effects of climate change on O3 but fewer studies on the effects of climate change on PM concentrations. Under the latest Intergovernmental Panel on Climate Change (IPCC) 5th assessment report (AR5) Representative Concentration Pathways (RCPs), background O3 entering Europe is expected to decrease under most scenarios due to higher water vapour concentrations in a warmer climate...
December 5, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29216172/enhancement-of-bulk-second-harmonic-generation-from-silicon-nitride-films-by-material-composition
#4
K Koskinen, R Czaplicki, A Slablab, T Ning, A Hermans, B Kuyken, V Mittal, G S Murugan, T Niemi, R Baets, M Kauranen
We present a comprehensive tensorial characterization of second-harmonic generation from silicon nitride films with varying compositions. The samples were fabricated using plasma-enhanced chemical vapor deposition, and the material composition was varied by the reactive gas mixture in the process. We found a six-fold enhancement between the lowest and highest second-order susceptibility, with the highest value of approximately 5 pm/V from the most silicon-rich sample. Moreover, the optical losses were found to be sufficiently small (below 6 dB/cm) for applications...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29216169/nonlinear-optical-susceptibility-of-two-dimensional-ws2-measured-by-hyper-rayleigh-scattering
#5
Gregory T Forcherio, Jérémy Riporto, Jeremy R Dunklin, Yannick Mugnier, Ronan Le Dantec, Luigi Bonacina, D Keith Roper
Hyper Rayleigh scattering (HRS) was used to measure the second-order nonlinear susceptibility, χ(2), for liquid exfoliated WS2 monolayers. To the best of our knowledge, it is the first reported application of the HRS technique to assess the bulk-like χ(2) of a two-dimensional (2D) material. The concentration-dependent HRS signal indicated a 4.90±0.30×10-25  esu first hyperpolarizability for 42 nm WS2 monolayers under 1064 nm laser irradiation using para-nitroaniline as an external reference. The corresponding value of χxxx(2) was calculated to be 460±28  pm V-1...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29209647/targeting-ras-will-gpr31-deliver-us-a-new-path-forward
#6
Nicole Fehrenbacher, Mark R Philips
Effective anti-rat sarcoma viral oncogene (RAS) therapies have remained the holy grail of cancer treatment. Mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) sustains tumorigenesis when linked to the plasma membrane (PM). The G protein-coupled receptor 31 (GPR31) is now identified to mediate KRAS membrane association and is crucial for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells, suggesting that GPR31 is a druggable target for anti-RAS therapy.
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/29208686/effects-of-growth-hormone-administration-on-luteinizing-hormone-secretion-in-healthy-older-men-and-women
#7
Ranganath Muniyappa, Shannon D Sullivan, Sri Harsha Tella, Brent S Abel, S Mitchell Harman, Marc R Blackman
The known interactions between the somatotropic and hypothalamic-pituitary-gonadal (HPG) axes have not been well delineated in older individuals. Aging-associated decline in insulin like growth factor-1 (IGF-1) levels has been proposed to play a role in reproductive senescence in animals. However, the effects of GH on LH secretion are unknown in older individuals. Our objective was to determine whether GH modulates LH secretion or levels of sex steroids (SS) in healthy older (ages 65-88 years) men (n = 24) and women (n = 24) with low-normal plasma IGF-1 levels...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29206984/rational-urine-drug-monitoring-in-patients-receiving-opioids-for-chronic-pain-consensus-recommendations
#8
Charles E Argoff, Daniel P Alford, Jeffrey Fudin, Jeremy A Adler, Matthew J Bair, Richard C Dart, Roy Gandolfi, Bill H McCarberg, Steven P Stanos, Jeffrey A Gudin, Rosemary C Polomano, Lynn R Webster
Objective: To develop consensus recommendations on urine drug monitoring (UDM) in patients with chronic pain who are prescribed opioids. Methods: An interdisciplinary group of clinicians with expertise in pain, substance use disorders, and primary care conducted virtual meetings to review relevant literature and existing guidelines and share their clinical experience in UDM before reaching consensus recommendations. Results: Definitive (e...
December 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29205433/faculty-feedback-that-begins-with-resident-self-assessment-motivation-is-the-key-to-success
#9
Alex Moroz, Margaret Horlick, Neil Mandalaywala, David T Stern
CONTEXT: The seeking and incorporating of feedback are necessary for continuous performance improvement in medicine. We know that beginning feedback conversations with resident self-assessment may reduce some of the tensions experienced by faculty staff. However, we do not fully understand how residents experience feedback that begins with self-assessment, and whether any existing theoretical frameworks can explain their experiences. METHODS: We conducted a constructivist grounded theory study exploring physical medicine and rehabilitation residents' experiences as they engaged in a structured self-assessment and faculty staff feedback programme...
December 4, 2017: Medical Education
https://www.readbyqxmd.com/read/29194198/latanoprostene-bunod-0-024-in-subjects-with-open-angle-glaucoma-or-ocular-hypertension-pooled-phase-3-study-findings
#10
Robert N Weinreb, Jeffrey M Liebmann, Keith R Martin, Paul L Kaufman, Jason L Vittitow
PURPOSE: To compare the diurnal intraocular pressure (IOP)-lowering effect of latanoprostene bunod (LBN) 0.024% with timolol maleate 0.5% in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT). PATIENTS AND METHODS: Pooled analysis of two phase 3, randomized, multicenter, double-masked, parallel-group, noninferiority trials (APOLLO and LUNAR), each with open-label safety extension phases. Adults with OAG or OHT were randomized 2:1 to double-masked treatment with LBN once daily (qd) or timolol twice daily (bid) for 3 months followed by open-label LBN treatment for 3 (LUNAR) or 9 (APOLLO) months...
November 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29193794/making-stillbirths-visible-a-systematic-review-of-globally-reported-causes-of-stillbirth
#11
REVIEW
H E Reinebrant, S H Leisher, M Coory, S Henry, A M Wojcieszek, G Gardener, R Lourie, D Ellwood, Z Teoh, E Allanson, H Blencowe, E S Draper, J J Erwich, J F Frøen, J Gardosi, K Gold, S Gordijn, A Gordon, Aep Heazell, T Y Khong, F Korteweg, J E Lawn, E M McClure, J Oats, R Pattinson, K Pettersson, D Siassakos, R M Silver, Gcs Smith, Ö Tunçalp, V Flenady
BACKGROUND: Stillbirth is a global health problem. The World Health Organization (WHO) application of the International Classification of Diseases for perinatal mortality (ICD-PM) aims to improve data on stillbirth to enable prevention. OBJECTIVES: To identify globally reported causes of stillbirth, classification systems, and alignment with the ICD-PM. SEARCH STRATEGY: We searched CINAHL, EMBASE, Medline, Global Health, and Pubmed from 2009 to 2016...
November 29, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29192063/mechanism-of-inhibition-of-taurolithocholate-induced-retrieval-of-plasma-membrane-mrp2-by-cyclic-amp-and-tauroursodeoxycholate
#12
Se Won Park, Cynthia R L Webster, Mohammed S Anwer
Taurolithocholate (TLC) produces cholestasis by inhibiting biliary solute secretion in part by retrieving MRP2 from the plasma membrane (PM). Tauroursodeoxycholate (TUDC) and cAMP reverse TLC-induced cholestasis by inhibiting TLC-induced retrieval of MRP2. However, cellular mechanisms for this reversal are incompletely understood. Recently, we reported that TLC decreases PM-MRP2 by activating PKCε followed by phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS). Thus, cAMP and TUDC may reverse TLC-induced cholestasis by inhibiting the TLC/PKCε/MARCKS phosphorylation pathway...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29189304/interventional-pain-procedures-in-physical-medicine-and-rehabilitation-residencies
#13
Sanjeev Agarwal, Caitlin Cicone, Philip Chang
Exposure to interventional pain procedures is now a required component of training in physical medicine and rehabilitation (PM&R) residencies as mandated by the Accreditation Council for Graduate Medical Education (ACGME). Data regarding resident exposure and competency in these procedures remains limited. Objectives were to determine the volume and type of exposure PM&R residents have to interventional pain procedures and to obtain faculty-perceived opinions regarding competency of incoming fellows as it pertains to interventional pain management...
November 20, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29189210/the-emergence-of-the-rehabilitative-strategy-the-driving-forces-in-the-united-states-of-america
#14
Armando Caracheo, Jerome Bickenbach, Gerold Stucki
The aim of this essay is to show the impact that driving forces have had on the emergence of rehabilitation as a health strategy in the USA. Specifically, this essay 1) identifies the driving forces that have addressed the development of rehabilitation, 2) examines how the rehabilitative strategy has been driven by the driving forces through turning points and facilitators, and 3) identifies the barriers of each force against the development of rehabilitation. Critical and scoping review of the literature was conducted from the late 1910s until the end of the century...
November 18, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29179573/the-value-of-rehabilitation-medicine-for-patients-receiving-palliative-care
#15
Sarah A Wittry, Ny-Ying Lam, Thomas McNalley
BACKGROUND: Rehabilitation medicine is a multidisciplinary field aimed at improving patients' quality of life by improving function. Patients receiving palliative care frequently share common symptoms including fatigue, decreased functional independence, mood disorders, pain, and breathlessness. Many rehabilitation interventions can improve these symptoms. OBJECTIVE: To evaluate the scope and effectiveness of rehabilitation interventions and exercise programs in improving quality of life and distressing symptoms in patients receiving palliative care...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29172680/efficacy-and-safety-of-hld200-delayed-release-and-extended-release-methylphenidate-in-children-with-attention-deficit-hyperactivity-disorder
#16
Steven R Pliszka, Timothy E Wilens, Samantha Bostrom, Valerie K Arnold, Andrea Marraffino, Andrew J Cutler, Frank A López, Norberto J DeSousa, Floyd R Sallee, Bev Incledon, Jeffrey H Newcorn
OBJECTIVE: Evening-dosed HLD200 is a delayed-release and extended-release methylphenidate (DR/ER-MPH) formulation consisting of uniform, dual-layered microbeads with an inner drug-loaded core. DR/ER-MPH is designed to delay the initial release of drug by 8-10 hours, and thereafter, provide a controlled, extended drug release to target onset of effect upon awakening that lasts into the evening. This phase 3 study evaluated the safety and efficacy of DR/ER-MPH on symptoms and temporal at-home functional impairment in children with attention-deficit/hyperactivity disorder (ADHD)...
August 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29168054/cardiac-function-in-patients-with-polymyositis-or-dermatomyositis-a-three-dimensional-speckle-tracking-echocardiography-study
#17
Yue Zhong, Wenjuan Bai, Qibing Xie, Jianhong Sun, Hong Tang, Li Rao
Cardiac event is a major cause of death in patients with idiopathic inflammatory myopathies (IIM). The most frequent IIMs are polymyositis (PM) and dermatomyositis (DM). The purpose of this study was to analyze cardiac involvement by three-dimensional speckle-tracking echocardiography (3D STE) in patients with PM or DM, and to identify the relationship of cardiac injury with clinical characteristics and disease-specific parameters. 60 PM/DM patients with preserved left ventricular ejection fraction and 30 matched healthy controls were assessed by conventional echocardiography, 3D STE with biventricular strain analysis and electrocardiogram...
November 22, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29162610/angiography-versus-hemodynamics-to-predict-the-natural-history-of-coronary-stenoses-a-fame-2-substudy
#18
Giovanni Ciccarelli, Emanuele Barbato, Gabor G Toth, Brigitta Gahl, Panagiotis Xaplanteris, Stephane Fournier, Anastasios Milkas, Jozef Bartunek, Marc Vanderheyden, Nico Pijls, Pim Tonino, William F Fearon, Peter Jüni, Bernard De Bruyne
Background -Among patients with documented stable coronary artery disease (CAD) and in whom no revascularization was performed, we compared the respective values of angiographic diameter stenosis (DS) and of fractional flow reserve (FFR) in predicting natural history. Methods -The present analysis included the 607 patients from the Fractional flow reserve versus angiography in multivessel evaluation 2 (FAME 2) trial in whom no revascularization was performed. FFR varied from 0.20 to 1.00 (average 0.74 ± 0...
November 21, 2017: Circulation
https://www.readbyqxmd.com/read/29158292/sphingomyelin-metabolism-is-a-regulator-of-kras-function
#19
Dharini van der Hoeven, Kwang-Jin Cho, Yong Zhou, Xiaoping Ma, Wei Chen, Ali Naji, Dina Montufar-Solis, Yan Zuo, Sarah E Kovar, Kandice R Levental, Jeffrey A Frost, Ransome van der Hoeven, John F Hancock
KRAS must localize to the plasma membrane (PM) for biological activity. We show here that multiple acid sphingomyelinase (ASM) inhibitors, including tricyclic antidepressants, mislocalized phosphatidylserine (PtdSer) and KRASG12V from the PM; resulting in abrogation of KRASG12V signaling and potent, selective growth inhibition of mutant KRAS transformed cancer cells. Concordantly, in nude mice, the ASM inhibitor fendiline decreased the rate of growth of oncogenic KRAS-expressing MiaPaCa-2 tumors, but had no effect on the growth of the wild-type KRAS-expressing BxPC-3 tumors...
November 20, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29157539/physical-medicine-and-rehabilitation-value-in-bundled-payment-for-total-joint-replacement-and-cardiac-surgery-the-rusk-experience
#20
REVIEW
Steven R Flanagan, Jonathan Whiteson, Geoffrey Hall, Christopher J Standaert
No abstract text is available yet for this article.
November 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
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