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JOURNAL ARTICLE
Thiol functionalized supports for controlled metal nanoparticle formation for improved C-C coupling.
Matthew E Potter, Joshua J M Le Brocq, Alice E Oakley, Evangeline B McShane, Panashe M Mhembere, Marina Carravetta, Bart D Vandegehuchte, Robert Raja
The myriad applications of metal nanoparticle systems have individual demands on their size, shape and electronic states, demanding novel synthetic methods to optimise these properties. Herein we report our method of exploiting strong thiol-Pd binding as a precursor for forming small, uniform Pd nanoparticles on activation. We validate our approach with a range of characterisation techniques and contrast our design strategy with an analogous wetness impregnation method, showing the drastic improvements for catalytic C-C coupling...
September 10, 2021: Chemistry, An Asian Journal
#22
REVIEW
Priyanka Verma, Joshua J M Le Brocq, Robert Raja
Harnessing solar energy and converting it into renewable fuels by chemical processes, such as water splitting and carbon dioxide (CO2 ) reduction, is a highly promising yet challenging strategy to mitigate the effects arising from the global energy crisis and serious environmental concerns. In recent years, covalent organic framework (COF)-based materials have gained substantial research interest because of their diversified architecture, tunable composition, large surface area, and high thermal and chemical stability...
July 9, 2021: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#23
REVIEW
A Chiriac, C Birsan, M Mares, Uwe Wollina
Tinea capitis is seen world-wide among children up to 12 years. The most severe type is Kerion Celsi with painful abscesses and lymphadenopathy. We report on an 11-year-old boy with Kerion Celsi, who was initially treated using antibiotics under the common misdiagnosis of a bacterial infection. Mycological investigations could identify Microsporum canis. The patient was treated orally with griseofulvin, which resulted in complete mycological remission after 8 weeks. Cicatrical alopecia, however, could not be prevented...
October 2021: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
#24
JOURNAL ARTICLE
Nicolas Paleiron, Aurélie Mayet, Vanessa Marbac, Anne Perisse, Hélène Barazzutti, François-Xavier Brocq, Frédéric Janvier, Bertrand Dautzenberg, Olivier Bylicki
INTRODUCTION: Preliminary reports indicated that smokers could be less susceptible to coronavirus SARS-CoV-2, which causes Covid-19. However, once infected an increased risk of severe disease is reported. We investigated the association between smoking and COVID-19 during an outbreak of the disease on a naval vessel. METHODS: We conducted a cross-sectional, observational study on the 1769 sailors of the same navy aircraft carrier at sea exposed at the same time to SARS-CoV2 to investigate the link between tobacco consumption and Covid-19...
August 4, 2021: Nicotine & Tobacco Research
#25
JOURNAL ARTICLE
Marie-Louise Frémond, Alice Hadchouel, Laureline Berteloot, Isabelle Melki, Violaine Bresson, Laura Barnabei, Nadia Jeremiah, Alexandre Belot, Vincent Bondet, Olivier Brocq, Damien Chan, Rawane Dagher, Jean-Christophe Dubus, Darragh Duffy, Séverine Feuillet-Soummer, Mathieu Fusaro, Marco Gattorno, Antonella Insalaco, Eric Jeziorski, Naoki Kitabayashi, Mireia Lopez-Corbeto, Françoise Mazingue, Marie-Anne Morren, Gillian I Rice, Jacques G Rivière, Luis Seabra, Jérôme Sirvente, Pere Soler-Palacin, Nathalie Stremler-Le Bel, Guillaume Thouvenin, Caroline Thumerelle, Eline Van Aerde, Stefano Volpi, Sophie Willcocks, Carine Wouters, Sylvain Breton, Thierry Molina, Brigitte Bader-Meunier, Despina Moshous, Alain Fischer, Stéphane Blanche, Frédéric Rieux-Laucat, Yanick J Crow, Bénédicte Neven
BACKGROUND: Gain-of-function mutations in STING1 underlie a type I interferonopathy termed SAVI (STING-associated vasculopathy with onset in infancy). This severe disease is variably characterized by early-onset systemic inflammation, skin vasculopathy, and interstitial lung disease (ILD). OBJECTIVE: To describe a cohort of patients with SAVI. METHODS: Assessment of clinical, radiological and immunological data from 21 patients (17 families) was carried out...
February 2021: Journal of Allergy and Clinical Immunology in Practice
#26
JOURNAL ARTICLE
Laëtitia Corgie, Nicolas Huiban, Jean-Michel Pontier, François-Xavier Brocq, Jean-François Boulard, Marc Monteil
BACKGROUND: Scuba diving activities expose divers to serious accidents, which can require early hospitalization. Helicopters are used for early evacuation. On the French Mediterranean coast, rescue is made offshore mainly by a French Navy Dauphin or at a landing zone by an emergency unit EC 135 helicopter. METHODS: We retrospectively analyzed diving accidents evacuated by helicopter on the French Mediterranean coast from 1 September 2014 to 31 August 2016. We gathered data at the Center for Hyperbaric Medicine and Diving Expertise (SMHEP) of the Sainte-Anne Military Hospital (Toulon, France), the 35 F squadron at Hyres (France) Naval Air Station, and the SAMU 83 emergency unit (Toulon, France)...
October 1, 2020: Aerospace Medicine and Human Performance
#27
JOURNAL ARTICLE
Signe Hässler, Delphine Bachelet, Julianne Duhaze, Natacha Szely, Aude Gleizes, Salima Hacein-Bey Abina, Orhan Aktas, Michael Auer, Jerôme Avouac, Mary Birchler, Yoram Bouhnik, Olivier Brocq, Dorothea Buck-Martin, Guillaume Cadiot, Franck Carbonnel, Yehuda Chowers, Manuel Comabella, Tobias Derfuss, Niek De Vries, Naoimh Donnellan, Abiba Doukani, Michael Guger, Hans-Peter Hartung, Eva Kubala Havrdova, Bernhard Hemmer, Tom Huizinga, Kathleen Ingenhoven, Poul Erik Hyldgaard-Jensen, Elizabeth C Jury, Michael Khalil, Bernd Kieseier, Anna Laurén, Raija Lindberg, Amy Loercher, Enrico Maggi, Jessica Manson, Claudia Mauri, Badreddine Mohand Oumoussa, Xavier Montalban, Maria Nachury, Petra Nytrova, Christophe Richez, Malin Ryner, Finn Sellebjerg, Claudia Sievers, Dan Sikkema, Martin Soubrier, Sophie Tourdot, Caroline Trang, Alessandra Vultaggio, Clemens Warnke, Sebastian Spindeldreher, Pierre Dönnes, Timothy P Hickling, Agnès Hincelin Mery, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Xavier Mariette, Marc Pallardy, Philippe Broët
BACKGROUND: Biopharmaceutical products (BPs) are widely used to treat autoimmune diseases, but immunogenicity limits their efficacy for an important proportion of patients. Our knowledge of patient-related factors influencing the occurrence of antidrug antibodies (ADAs) is still limited. METHODS AND FINDINGS: The European consortium ABIRISK (Anti-Biopharmaceutical Immunization: prediction and analysis of clinical relevance to minimize the RISK) conducted a clinical and genomic multicohort prospective study of 560 patients with multiple sclerosis (MS, n = 147), rheumatoid arthritis (RA, n = 229), Crohn's disease (n = 148), or ulcerative colitis (n = 36) treated with 8 different biopharmaceuticals (etanercept, n = 84; infliximab, n = 101; adalimumab, n = 153; interferon [IFN]-beta-1a intramuscularly [IM], n = 38; IFN-beta-1a subcutaneously [SC], n = 68; IFN-beta-1b SC, n = 41; rituximab, n = 31; tocilizumab, n = 44) and followed during the first 12 months of therapy for time to ADA development...
October 2020: PLoS Medicine
#28
JOURNAL ARTICLE
Manon Fraulob, Siyuan Pang, Sophie Le Cann, Romain Vayron, Mathilde Laurent-Brocq, Soorya Todatry, Julio A N T Soares, Iwona Jasiuk, Guillaume Haïat
Titanium implants are widely used in dental and orthopedic surgeries. Osseointegration phenomena lead to direct contact between bone tissue and the implant surface. The quality of the bone-implant interface (BII), resulting from the properties of newly formed bone, determines the implant stability. This study investigates the BII properties using a dedicated in vivo implant model consisting of a coin-shaped Ti-6Al-4V implant inserted in a rabbit femur for 10 weeks. A gap created below the implant was filled with newly formed bone tissue after healing...
October 2020: Medical Engineering & Physics
#29
JOURNAL ARTICLE
S Le Brocq, K Clare, M Bryant, K Roberts, A A Tahrani
No abstract text is available yet for this article.
August 2020: Lancet Diabetes & Endocrinology
#30
REVIEW
Charlotte Albury, W David Strain, Sarah Le Brocq, Jennifer Logue, Cathy Lloyd, Abd Tahrani
Obesity is a chronic condition that requires long-term management and is associated with unprecedented stigma in different settings, including during interactions with the health-care system. This stigma has a negative effect on the mental and physical health of people with obesity and can lead to avoidance of health care and disruption of the doctor-patient relationship. Considerable evidence exists to suggest that simply having a conversation about obesity can lead to weight loss, which translates into health benefits...
May 2020: Lancet Diabetes & Endocrinology
#31
JOURNAL ARTICLE
Laëtitia Corgie, Nicolas Huiban, Laetitia Quesnel, François-Xavier Brocq, Jean-François Boulard, Marc Monteil
BACKGROUND: The stroboscopic effect made by helicopter blades passing through rays of sunlight is known as a factor that can induce an epileptic seizure. CASE REPORT: We report a case of inaugural tonic-clonic generalized seizure while refueling an NH 90 helicopter by an aeronautical technician standing under the rotating main rotor on a sunny day at a South of France naval air station. The stroboscopic effect of the helicopter blades was identified as one of the factors involved in the induction of this seizure...
October 1, 2019: Aerospace Medicine and Human Performance
#32
LETTER
Olivier Brocq, Emilie Acquacalda, Amélie Florent, Tristan Lascar
No abstract text is available yet for this article.
September 11, 2019: Joint, Bone, Spine: Revue du Rhumatisme
#33
REVIEW
Chloe Ekelem, Christine Pham, Natasha Atanaskova Mesinkovska
IMPORTANCE: Hair loss, or alopecia, is one of the most commonly presented problems in dermatology. Scarring alopecias are considered particularly damaging due to limited success in slowing permanent disease progression, and current treatment methods, such as intralesional and topical steroids and topical minoxidil, are largely ineffective. OBJECTIVE: Hair transplantation is a debated treatment option for advanced cases of primary scarring alopecia. This study reviews the efficacy of hair transplantation as a treatment option for primary scarring alopecia...
February 2019: Skin Appendage Disorders
#34
JOURNAL ARTICLE
M Olivetto, J Bettoni, S Testelin, S Dakpé, B Devauchelle
Born at the late 19th century, Suzanne Noël achieved, despite prejudices, to become at the same time the first female cosmetic surgeon and an influential feminist activist. Trained as a dermatologist by Professor Brocq, she first became fascinated by rejuvenation surgery during her studies by meeting Sarah Bernardh, who had undergone a facelift in the United States. As a surgeon, she mainly performed procedures under local anaesthesia in her salon, where she maintains worldly relations with her women clients...
February 19, 2019: Annales de Chirurgie Plastique et Esthétique
#35
JOURNAL ARTICLE
Radhika Agarwal, Meeta Singh, Reema Dahiya, Vishal Singh, Dimple Chaudhary, Nita Khurana, Vijay Kumar Garg
OBJECTIVES: To study the direct immunofluorescence (DIF) in cicatricial alopecia (CA) patients. MATERIALS AND METHODS: Approximately, 155 skin biopsies from CA patients examined over 7 years (2009-2015). Special stains and Hematoxylin and Eosin were performed, and final histopathological diagnosis was made. DIF (against anti-IgG, IgM, C3, IgA, and fibrinogen) on all these cases and patterns were noted. The descriptive statistics were applied along with ANOVA test...
January 2019: Indian Journal of Pathology & Microbiology
#36
JOURNAL ARTICLE
Hard rock landforms generate 130 km ice shelf channels through water focusing in basal corrugations.
Hafeez Jeofry, Neil Ross, Anne Le Brocq, Alastair G C Graham, Jilu Li, Prasad Gogineni, Mathieu Morlighem, Thomas Jordan, Martin J Siegert
Satellite imagery reveals flowstripes on Foundation Ice Stream parallel to ice flow, and meandering features on the ice-shelf that cross-cut ice flow and are thought to be formed by water exiting a well-organised subglacial system. Here, ice-penetrating radar data show flow-parallel hard-bed landforms beneath the grounded ice, and channels incised upwards into the ice shelf beneath meandering surface channels. As the ice transitions to flotation, the ice shelf incorporates a corrugation resulting from the landforms...
November 1, 2018: Nature Communications
#37
JOURNAL ARTICLE
R Demoulin, R Poyet, E Capilla, A V Tortat, F Pons, F-X Brocq, A Druelle, C Jego, G Foucault, G-R Cellarier
Doping is the use of a substance that artificially increases an individual's physical ability for competition purpose. Products and methods used in doping are not without risk, especially at cardiovascular level. Here we review the most common doping substances in sport and their cardiovascular consequences.
October 2, 2018: Annales de Cardiologie et D'angéiologie
#38
JOURNAL ARTICLE
Mohamed Elqatni, Hassan Qacif, Mohamed Zyani, Driss Ghafir, Toufiq Amezyane
No abstract text is available yet for this article.
June 2018: La Presse Médicale
#39
JOURNAL ARTICLE
C Julien, J Laroche, F-X Deledalle, F-X Brocq, R Fournier, P Rivière, E Lechevallier, P-H Savoie
INTRODUCTION: Military people are inapt for presence of urinary stones. In this specific population, the treatment of stones is even more aggressive than for the general population without recommendation. The final decision about aptitude is the responsibility of the military doctor. Whereas, ureteroscopy has its place there and must done by any urologist. METHODS: The purpose of this study was to estimate the results of treatments by ureteroscopy in this population...
May 2018: Progrès en Urologie
#40
JOURNAL ARTICLE
Hsing-Jou Su, An-Yu Cheng, Cheng-Han Liu, Chia-Bau Chu, Chaw-Ning Lee, Chao-Kai Hsu, Julia Yu-Yun Lee, Chao-Chun Yang
Primary scarring alopecia (PSA) is caused by irreversible damage to the hair epithelial stem cells that reside in hair follicles. There is limited published work regarding PSA amongst the Asian population. The aim of this study was to evaluate the clinical features and to characterize the subtypes of PSA in southern Taiwan. In this retrospective case series, we reviewed 89 patients with pathology-confirmed PSA. The data was collected from National Cheng Kung University Hospital between 1988 through 2016. The clinical and histological data were reviewed, and the patients were characterized into different subtypes of PSA based on the clinical features and histological findings...
April 2018: Journal of Dermatology
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