Read by QxMD icon Read


Kave Shams, Gillian Wilson, Mark Singh, Ellen van den Bogaard, Michelle L Le Brocq, Susan Holmes, Joost Schalkwijk, A David Burden, Clive S McKimmie, Gerard J Graham
Elucidating the poorly defined mechanisms by which inflammatory lesions are spatially restricted in vivo, is of critical importance in understanding skin disease. Chemokines are the principal regulators of leukocyte migration and are essential in the initiation and maintenance of inflammation. The membrane-bound psoriasis associated atypical chemokine receptor ACKR2 binds, internalises and degrades most pro-inflammatory CC-chemokines. Here we investigate the role of ACKR2 in limiting the spread of cutaneous psoriasiform inflammation to sites that are remote from the primary lesion...
August 25, 2016: Journal of Investigative Dermatology
Sarita Kalwaniya, Manjaree Morgaonkar, Savera Gupta, Suresh Kumar Jain
Erythromelanosis follicularis faciei et colli (EFFC) is a rare disease characterized by a triad of reddish-brown pigmentation, erythema and follicular papules localized on face and neck and is usually described in males. Erythrosis pigmentosa mediofacialis (also known as Brocq or erythrosis pigmentosa peribuccalis) is a similar disorder of the mediofacial area but with female predominance. We report a case of simultaneous occurrence of erythrosis pigmentosa peribuccalis and EFFC associated with keratosis pilaris in an adolescent female...
July 2016: Indian Journal of Dermatology
Mohsen Pourmorteza, Fady Tawadros, Gilbert Bader, Mohamed Al-Tarawneh, Emilie Cook, Wael Shams, Mark Young
BACKGROUND: Pyoderma gangrenosum is a rare, ulcerative cutaneous condition that was first described by Brocq in 1916. This diagnosis is quite challenging as the histopathological findings are nonspecific. Pyoderma gangrenosum is usually associated with inflammatory bowel disease, leukemia, and hepatitis C. We describe a rare clinical case of a patient with hepatitis C (HCV), mixed cryoglubinemia, and pyoderma gangrenosum, which was successfully treated with prednisone in combination with the new antiviral medication ledipasvir/sofosbuvir...
2016: American Journal of Case Reports
Dorothea Sander, Josef Schröder, Ines Schönbuchner, Julia Schreml, Sigrid Karrer, Mark Berneburg, Stephan Schreml
A 50-year-old man presented with congenital scaling and hyperkeratosis on his palms, the soles of his feet and the extensor areas of his joints. The flexural areas were unaffected. His maternal grandmother, questionably his maternal uncle, his mother, all three brothers, one of his two sisters as well as two nephews and three nieces have or had similar skin changes. A punch biopsy was taken from the left palm. Clinical and histological signs led to the diagnosis of erythrodermia congenitalis ichthyosiformis bullosa of Brocq...
January 2016: Case Reports in Dermatology
Olivier Brocq, Emilie Acquacalda, Frédéric Berthier, Christine Albert, Gilles Bolla, Elodie Millasseau, Claire Destombe, Johanna Azulay, Caroline Asquier, Amélie Florent, Sylvie Le Seaux, Liana Euller-Ziegler
OBJECTIVES: To evaluate influenza and pneumococcal vaccine coverage in patients taking biological therapy for chronic inflammatory joint disease and to identify factors associated with the decision to administer these two vaccines. METHODS: Retrospective cross-sectional questionnaire study of a cohort of 584 patients taking biological therapy for chronic inflammatory joint disease (rheumatoid arthritis or spondyloarthritis). We studied the influenza and pneumococcal vaccine coverage rates, information about these vaccines given to patients by the primary-care physician and rheumatologist, and reasons for not administering the vaccines...
March 2016: Joint, Bone, Spine: Revue du Rhumatisme
Binod Kumar Thakur, Shikha Verma, Vandana Raphael
BACKGROUND: The primary cicatricial alopecias (PCAs) are a rare group of diseases where hair follicle is the primary target of destruction. There are a few studies on histopathological and trichoscopic features of PCA. AIMS: To study the clinical, trichoscopic, and histopathological characteristics of PCAs of the scalp and to find out the concordance between trichoscopic and histopathological diagnosis. MATERIALS AND METHODS: We retrospectively analyzed the clinical, trichoscopic, and histopathological features of 24 PCA patients...
July 2015: International Journal of Trichology
Sharad Mehta, Uma Shankar Agarwal, Nidheesh Agarwal
Ichthyosis hystrix is a rare autosomal dominant genodermatosis, characterized by persistent spiny hyperkeratotic scales which cover a significant part of the skin surface. Based on the pattern of distribution, five clinical variants namely Brocq type, Lambert type, Curth-Macklin type, Rheydt type and Bδfverstedt type have been described. We report the case of an 11-year-old male child with spiny, hyperkeratotic scales all over the body since birth with sparing of scalp and central part of the face. Palmoplantar keratoderma was also present...
September 2015: Indian Journal of Dermatology
R Poyet, E Capilla, A V Tortat, F X Brocq, F Pons, S Kerebel, C Jego, G R Cellarier
Cardiac allograft vasculopathy is the major determinant of long-term survival in patients after heart transplantation. Clinical presentations are congestive heart failure, ventricular arrhythmias and sudden cardiac death. Acute coronary syndrome is a rare presentation of cardiac allograft vasculopathy due to myocardial denervation. We present the case of a 31-year-old patient, who had undergone heart transplantation 6 months earlier and who developed a painless anterior myocardial infarction revealed by syncope...
November 2015: Annales de Cardiologie et D'angéiologie
Dimitrios Rigopoulos, Gregoriou Stamatios, Dimitrios Ioannides
Scarring alopecia or cicatricial alopecia results from follicular damage that is sufficient to cause the destruction and replacement of pilosebaceous structures by scar tissue. Primary scarring alopecias represent a group of disorders that primarily affect the hair follicles, as opposed to secondary scarring alopecias, which affect the dermis and secondarily cause follicular destruction. Inflammation may predominantly involve lymphocytes or neutrophils. Cicatricial alopecias that mainly involve lymphocytic inflammation include discoid lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia, central centrifugal alopecia, and pseudopelade (Brocq)...
2015: Current Problems in Dermatology
E Capilla-Geay, R Poyet, F X Brocq, F Pons, S Kerebel, G Foucault, C Jego, G R Cellarier
INTRODUCTION: Antiphospholipid syndrome is an autoimmune disorder causing venous and arterial thrombosis. Acute coronary complications are rare but potentially dramatic. CASE REPORT: We report a 39-year-old woman who presented with an acute anterior myocardial infarction after intravenous corticosteroids as part of the treatment of lupus arthritis and revealing antiphospholipid syndrome. Emergency coronary angiography was performed with drug-eluting stent angioplasty despite the need for anticoagulation and dual antiplatelet therapy...
May 2016: La Revue de Médecine Interne
Eléonore Capilla, Raphael Poyet, Francois-Xavier Brocq, Frédéric Pons, Sébastien Kerebel, Christophe Jego, Pierre Laurent, Gilles Rolland Cellarier
Thanks to science advances, cancer is no longer synonymous with death. Life expectancy improvement reveals a new problem: cancer treatment toxicity, including cardiovascular complications, responsible for significant morbidity and mortality. Media scandal of drug-induced valvular heart disease did revise the risk-benefit balance of drugs used (often off-label) as anorectics. Today's society uses drugs heavily but does not accept their side effects. Knowledge and information of these complications is essential...
October 2015: La Presse Médicale
Bruno Fautrel, Thao Pham, Toni Alfaiate, Frédérique Gandjbakhch, Violaine Foltz, Jacques Morel, Emmanuelle Dernis, Philippe Gaudin, Olivier Brocq, Elisabeth Solau-Gervais, Jean-Marie Berthelot, Jean-Charles Balblanc, Xavier Mariette, Florence Tubach
UNLABELLED: Tumour necrosis factor (TNF)-blocker tapering has been proposed for patients with rheumatoid arthritis (RA) in remission. OBJECTIVE: The trial aims to compare the effect of progressive spacing of TNF-blocker injections (S-arm) to their maintenance (M-arm) for established patients with RA in remission. METHODS: The study was an 18-month equivalence trial which included patients receiving etanercept or adalimumab at stable dose for ≥1 year, patients in remission on 28-joint Disease Activity Score (DAS28) for ≥6 months and patients with stable joint damage...
January 2016: Annals of the Rheumatic Diseases
R Poyet, E Capilla, S Kerebel, F X Brocq, F Pons, C Jego, G R Cellarier
Coronary artery (CA) dissection following blunt chest trauma is a life-threatening and rare event. Its occurrence in the setting of a contact sport like rugby is even less common. We report on two cases of young adult presenting with segment elevation myocardial infarction related to CA dissection following rugby game. Both were successfully treated with stent implantation. We discuss the mechanism, diagnosis, and optimal management of blunt chest trauma-induced CA dissection.
April 2015: Journal of Emergencies, Trauma, and Shock
Mathilde Laurent-Brocq, Estelle Béjanin, Yannick Champion
A model, which takes into account the indentation size effect, was proposed to relate hardness and its standard deviation to the quality of the sample surface, i.e., the roughness and the tilt. Stainless steel samples were mechanically polished so as to obtain various roughness and tilt. Then the quality of the surface and the hardness were measured respectively by scanning probe microscopy and by nanoindentation. The model was fitted according to those experimental data. It was shown that the standard deviation only depends on the ratio of the arithmetic roughness over the contact depth of the indent while the average hardness also depends on the contact depth and on the tilt...
September 2015: Scanning
Vivek V Nikam, Hita H Mehta
AIMS: The aim was to study the trichoscopy features of selected hair and scalp conditions by two dermoscopic devices with different modes that is, polarized (noncontact) and nonpolarized (contact) mode. MATERIALS AND METHODS: The present study included 11 clinical varieties of cases with total 112 patients, attending Sir Takhtasinh Hospital, Bhavnagar in the last 2 years. The clinical history was recorded for each case, and images were taken in both the Heine and DermLite II pro dermatoscope...
April 2014: International Journal of Trichology
Nilofar Diwan, Sneha Gohil, Pragya A Nair
Pseudopelade of Brocq (PPB) is a rare, idiopathic self-limiting hair disorder resulting in progressive cicatricial alopecia primarily involving the parietal scalp and vertex. The general pathogenesis of scarring alopecias has been focused on theories of stem cell failure and sebaceous gland destruction. Acquired immunity, Borrelia infection and senescence of follicular stem cell reservoir plays suspected role. It classically presents as porcelain white hypopigmented and slightly depressed atrophic plaque. There is no standard treatment for PPB...
January 2014: International Journal of Trichology
Shiling Qi, Ying Zhao, Xiaoting Zhang, Shuifeng Li, Hui Cao, Xingqi Zhang
BACKGROUND: There have been few reports on primary cicatricial alopecias (PCR) especially from Asia (PCA). AIMS: To study the clinical, pathological and dermoscopic characteristics of PCA among Chinese patients. METHODS: A retrospective analysis of the clinical data of 59 patients with PCA was conducted and the dermoscopic, pathological, treatment and prognosis characteristics analyzed. Fisher's Chi-square exact test, Kruskal-Wallis and Spearman rank correlation test were performed...
July 2014: Indian Journal of Dermatology, Venereology and Leprology
Woo-Haing Shim, Seung-Wook Jwa, Margie Song, Hoon-Soo Kim, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim
BACKGROUND: Various kinds of alopecia can show small round or oval hairless patch. Dermoscopy could be a simple, useful tool for making a correct diagnosis. OBJECTIVE: The aim of this study is to investigate clinical usefulness of dermoscopy for diseases with small round or oval hairless patch on the scalp. METHODS: Dermoscopic examination was performed for 148 patients with small round or oval hairless patch using DermLite® II pro. The type and its patient number of alopecia investigated in the study were as below: alopecia areata (n=81), trichotillomania (n=24), tinea captis (n=13), traction alopecia (n=12), lichen planopilaris (n=8), discoid lupus erythematosus (n=7), congenital triangular alopecia (n=2) and pseudopelade of Brocq (n=1)...
April 2014: Annals of Dermatology
Michelle L Le Brocq, Alasdair R Fraser, Graham Cotton, Kerry Woznica, Clare V McCulloch, Kay D Hewit, Clive S McKimmie, Robert J B Nibbs, John D M Campbell, Gerard J Graham
Cell therapy regimens are frequently compromised by low-efficiency cell homing to therapeutic niches. Improvements in this regard would enhance effectiveness of clinically applicable cell therapy. The major regulators of tissue-specific cellular migration are chemokines, and therefore selection of therapeutic cellular populations for appropriate chemokine receptor expression would enhance tissue-homing competence. A number of practical considerations preclude the use of Abs in this context, and alternative approaches are required...
June 15, 2014: Journal of Immunology: Official Journal of the American Association of Immunologists
No abstract text is available yet for this article.
February 1950: British Journal of Dermatology and Syphilis
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"