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https://www.readbyqxmd.com/read/28140549/treatment-options-for-pyoderma-gangrenosum
#1
REVIEW
Sven R Quist, Luise Kraas
Pyoderma gangrenosum (PG) is an orphan disease. While research on such disorders is based on only few randomized multicenter as well as retrospective studies, most of the data comes from case series of small patient groups. Apart from topical and intralesional therapeutic options for early stages and mild disease courses, treatment predominantly involves systemic therapeutic agents. Besides systemic corticosteroids and cyclosporine A (CsA), options also include intravenous immunoglobulins (IVIG) and biologics such as the TNFα inhibitors infliximab, adalimumab, and etanercept; the interleukin (IL) 12/23 antibody ustekinumab; the IL-1 receptor antagonist anakinra; and the IL-1β antibody canakinumab...
January 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28140542/therapieoptionen-beim-pyoderma-gangraenosum
#2
REVIEW
Sven R Quist, Luise Kraas
Das Pyoderma gangraenosum (PG) gehört zu den orphan diseases, deren Erforschung sich lediglich auf einzelne, randomisierte, multizentrische sowie retrospektive Studien stützen kann und überwiegend auf Fallserien an kleinen Patientenkollektiven beruht. Die Therapie basiert neben topischen und lokal intraläsionalen Therapieoptionen, bei initialem und leichtem Krankheitsverlauf, insbesondere auf der Gabe von Systemtherapeutika. Diese beinhaltet neben den systemischen Glukokortikosteroiden und Ciclosporin A (CsA) auch Biologika wie intravenöses Immunglobulin G (IVIG), die TNFα-Inhibitoren Infliximab, Adalimumab und Etanercept, den IL-12/23-Antikörper Ustekinumab, den Interleukin-1-Rezeptorantagonist Anakinra und den Interleukin-1β-Antikörper Canakinumab...
January 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28093099/-infective-endocarditis-clinical-features-and-prognosis-between-2004%C3%A2-and-2014%C3%A2-in-a-non-teaching-hospital
#3
E Capilla, R Poyet, A-V Tortat, J Marchi, F-X Brocq, F Pons, S Kerebel, C Jego, A Mayet, G R Cellarier
AIMS: Despite diagnostic and therapeutic advances, infective endocarditis (IE) remains a severe disease. The aim of the study was to describe clinical features and prognosis of patients with IE in a non-teaching hospital and compare them with current data and a similar study conducted 10 years earlier in the same center. METHODS: We performed a single institution retrospective study including all patients with Duke-Li definite IE between 2004 and 2014. RESULTS: Ninety-four patients were included...
January 13, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28056915/predictors-of-response-to-viscosupplementation-in-patients-with-hip-osteoarthritis-results-of-a-prospective-observational-multicentre-open-label-pilot-study
#4
Florent Eymard, Bernard Maillet, Henri Lellouche, Sylvie Mellac-Ducamp, Olivier Brocq, Damien Loeuille, Xavier Chevalier, Thierry Conrozier
BACKGROUND: To identify predictive factors of response to viscosupplementation (VS) in patients with hip osteoarthritis (HOA). METHODS: Prospective, multicentre, open-label trial, achieved in daily practice conditions. Patients with HOA were treated with a single intra-articular injection of a cross-linked hyaluronic acid combined with mannitol (HAnox-M-XL), using imaging guidance. WOMAC pain and function scores and patient global assessment (PGA) were assessed at baseline and day 90...
January 6, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27846945/primary-cicatricial-alopecia-other-lymphocytic-primary-cicatricial-alopecias-and-neutrophilic-and-mixed-primary-cicatricial-alopecias
#5
REVIEW
Chantal Bolduc, Leonard C Sperling, Jerry Shapiro
Primary cicatricial alopecias can be frustrating for both patients and physicians. Proper diagnosis guides more successful management of these challenging conditions. Part II will cover the remaining lymphocytic primary cicatricial alopecias, which include pseudopelade of Brocq, central centrifugal cicatricial alopecia, alopecia mucinosa, and keratosis follicularis spinulosa decalvans. It will also discuss the neutrophilic and mixed primary cicatricial alopecias, namely folliculitis decalvans, dissecting cellulitis, folliculitis keloidalis, folliculitis (acne) necrotica, and erosive pustular dermatosis...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27568525/spread-of-psoriasiform-inflammation-to-remote-tissues-is-restricted-by-the-atypical-chemokine-receptor-ackr2
#6
Kave Shams, Gillian J Wilson, Mark Singh, Ellen H van den Bogaard, Michelle L Le Brocq, Susan Holmes, Joost Schalkwijk, A David Burden, Clive S McKimmie, Gerard J Graham
Elucidating the poorly defined mechanisms by which inflammatory lesions are spatially restricted in vivo is of critical importance in understanding skin disease. Chemokines are the principal regulators of leukocyte migration and are essential in the initiation and maintenance of inflammation. The membrane-bound psoriasis-associated atypical chemokine receptor 2 (ACKR2) binds, internalizes and degrades most proinflammatory CC-chemokines. Here we investigate the role of ACKR2 in limiting the spread of cutaneous psoriasiform inflammation to sites that are remote from the primary lesion...
January 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27512206/co-occurrence-of-erythrosis-pigmentosa-mediofacialis-and-erythromelanosis-follicularis-faciei-et-colli-associated-with-keratosis-pilaris-in-an-adolescent-female
#7
Sarita Kalwaniya, Manjaree Morgaonkar, Savera Gupta, Suresh Kumar Jain
Erythromelanosis follicularis faciei et colli (EFFC) is a rare disease characterized by a triad of reddish-brown pigmentation, erythema and follicular papules localized on face and neck and is usually described in males. Erythrosis pigmentosa mediofacialis (also known as Brocq or erythrosis pigmentosa peribuccalis) is a similar disorder of the mediofacial area but with female predominance. We report a case of simultaneous occurrence of erythrosis pigmentosa peribuccalis and EFFC associated with keratosis pilaris in an adolescent female...
July 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27345376/successful-treatment-of-pyoderma-gangrenosum-with-cryoglobulinemia-and-hepatitis-c
#8
Mohsen Pourmorteza, Fady Tawadros, Gilbert Bader, Mohamed Al-Tarawneh, Emilie Cook, Wael Shams, Mark Young
BACKGROUND: Pyoderma gangrenosum is a rare, ulcerative cutaneous condition that was first described by Brocq in 1916. This diagnosis is quite challenging as the histopathological findings are nonspecific. Pyoderma gangrenosum is usually associated with inflammatory bowel disease, leukemia, and hepatitis C. We describe a rare clinical case of a patient with hepatitis C (HCV), mixed cryoglubinemia, and pyoderma gangrenosum, which was successfully treated with prednisone in combination with the new antiviral medication ledipasvir/sofosbuvir...
June 27, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/26933410/erythrodermia-congenitalis-ichthyosiformis-bullosa-of-brocq
#9
Dorothea Sander, Josef Schröder, Ines Schönbuchner, Julia Schreml, Sigrid Karrer, Mark Berneburg, Stephan Schreml
A 50-year-old man presented with congenital scaling and hyperkeratosis on his palms, the soles of his feet and the extensor areas of his joints. The flexural areas were unaffected. His maternal grandmother, questionably his maternal uncle, his mother, all three brothers, one of his two sisters as well as two nephews and three nieces have or had similar skin changes. A punch biopsy was taken from the left palm. Clinical and histological signs led to the diagnosis of erythrodermia congenitalis ichthyosiformis bullosa of Brocq...
January 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/26725745/influenza-and-pneumococcal-vaccine-coverage-in-584-patients-taking-biological-therapy-for-chronic-inflammatory-joint-a-retrospective-study
#10
Olivier Brocq, Emilie Acquacalda, Frédéric Berthier, Christine Albert, Gilles Bolla, Elodie Millasseau, Claire Destombe, Johanna Azulay, Caroline Asquier, Amélie Florent, Sylvie Le Seaux, Liana Euller-Ziegler
OBJECTIVES: To evaluate influenza and pneumococcal vaccine coverage in patients taking biological therapy for chronic inflammatory joint disease and to identify factors associated with the decision to administer these two vaccines. METHODS: Retrospective cross-sectional questionnaire study of a cohort of 584 patients taking biological therapy for chronic inflammatory joint disease (rheumatoid arthritis or spondyloarthritis). We studied the influenza and pneumococcal vaccine coverage rates, information about these vaccines given to patients by the primary-care physician and rheumatologist, and reasons for not administering the vaccines...
March 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/26622153/clinical-trichoscopic-and-histopathological-features-of-primary-cicatricial-alopecias-a-retrospective-observational-study-at-a-tertiary-care-centre-of-north-east-india
#11
Binod Kumar Thakur, Shikha Verma, Vandana Raphael
BACKGROUND: The primary cicatricial alopecias (PCAs) are a rare group of diseases where hair follicle is the primary target of destruction. There are a few studies on histopathological and trichoscopic features of PCA. AIMS: To study the clinical, trichoscopic, and histopathological characteristics of PCAs of the scalp and to find out the concordance between trichoscopic and histopathological diagnosis. MATERIALS AND METHODS: We retrospectively analyzed the clinical, trichoscopic, and histopathological features of 24 PCA patients...
July 2015: International Journal of Trichology
https://www.readbyqxmd.com/read/26538731/a-sporadic-case-of-ichthyosis-curth-macklin-rare-presentation-of-a-rare-disease
#12
Sharad Mehta, Uma Shankar Agarwal, Nidheesh Agarwal
Ichthyosis hystrix is a rare autosomal dominant genodermatosis, characterized by persistent spiny hyperkeratotic scales which cover a significant part of the skin surface. Based on the pattern of distribution, five clinical variants namely Brocq type, Lambert type, Curth-Macklin type, Rheydt type and Bδfverstedt type have been described. We report the case of an 11-year-old male child with spiny, hyperkeratotic scales all over the body since birth with sparing of scalp and central part of the face. Palmoplantar keratoderma was also present...
September 2015: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/26472502/-painless-anterior-acute-myocardial-infarction-in-a-transplanted-heart
#13
R Poyet, E Capilla, A V Tortat, F X Brocq, F Pons, S Kerebel, C Jego, G R Cellarier
Cardiac allograft vasculopathy is the major determinant of long-term survival in patients after heart transplantation. Clinical presentations are congestive heart failure, ventricular arrhythmias and sudden cardiac death. Acute coronary syndrome is a rare presentation of cardiac allograft vasculopathy due to myocardial denervation. We present the case of a 31-year-old patient, who had undergone heart transplantation 6 months earlier and who developed a painless anterior myocardial infarction revealed by syncope...
November 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26370646/primary-scarring-alopecias
#14
REVIEW
Dimitrios Rigopoulos, Gregoriou Stamatios, Dimitrios Ioannides
Scarring alopecia or cicatricial alopecia results from follicular damage that is sufficient to cause the destruction and replacement of pilosebaceous structures by scar tissue. Primary scarring alopecias represent a group of disorders that primarily affect the hair follicles, as opposed to secondary scarring alopecias, which affect the dermis and secondarily cause follicular destruction. Inflammation may predominantly involve lymphocytes or neutrophils. Cicatricial alopecias that mainly involve lymphocytic inflammation include discoid lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia, central centrifugal alopecia, and pseudopelade (Brocq)...
2015: Current Problems in Dermatology
https://www.readbyqxmd.com/read/26363818/-acute-anterior-myocardial-infarction-as-presenting-feature-of-antiphospholipid-syndrome-related-lupus-arthritis
#15
E Capilla-Geay, R Poyet, F X Brocq, F Pons, S Kerebel, G Foucault, C Jego, G R Cellarier
INTRODUCTION: Antiphospholipid syndrome is an autoimmune disorder causing venous and arterial thrombosis. Acute coronary complications are rare but potentially dramatic. CASE REPORT: We report a 39-year-old woman who presented with an acute anterior myocardial infarction after intravenous corticosteroids as part of the treatment of lupus arthritis and revealing antiphospholipid syndrome. Emergency coronary angiography was performed with drug-eluting stent angioplasty despite the need for anticoagulation and dual antiplatelet therapy...
May 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/26153088/-drugs-cardiotoxicity
#16
REVIEW
Eléonore Capilla, Raphael Poyet, Francois-Xavier Brocq, Frédéric Pons, Sébastien Kerebel, Christophe Jego, Pierre Laurent, Gilles Rolland Cellarier
Thanks to science advances, cancer is no longer synonymous with death. Life expectancy improvement reveals a new problem: cancer treatment toxicity, including cardiovascular complications, responsible for significant morbidity and mortality. Media scandal of drug-induced valvular heart disease did revise the risk-benefit balance of drugs used (often off-label) as anorectics. Today's society uses drugs heavily but does not accept their side effects. Knowledge and information of these complications is essential...
October 2015: La Presse Médicale
https://www.readbyqxmd.com/read/26103979/step-down-strategy-of-spacing-tnf-blocker-injections-for-established-rheumatoid-arthritis-in-remission-results-of-the-multicentre-non-inferiority-randomised-open-label-controlled-trial-strass-spacing-of-tnf-blocker-injections-in-rheumatoid-arthritis-study
#17
RANDOMIZED CONTROLLED TRIAL
Bruno Fautrel, Thao Pham, Toni Alfaiate, Frédérique Gandjbakhch, Violaine Foltz, Jacques Morel, Emmanuelle Dernis, Philippe Gaudin, Olivier Brocq, Elisabeth Solau-Gervais, Jean-Marie Berthelot, Jean-Charles Balblanc, Xavier Mariette, Florence Tubach
UNLABELLED: Tumour necrosis factor (TNF)-blocker tapering has been proposed for patients with rheumatoid arthritis (RA) in remission. OBJECTIVE: The trial aims to compare the effect of progressive spacing of TNF-blocker injections (S-arm) to their maintenance (M-arm) for established patients with RA in remission. METHODS: The study was an 18-month equivalence trial which included patients receiving etanercept or adalimumab at stable dose for ≥1 year, patients in remission on 28-joint Disease Activity Score (DAS28) for ≥6 months and patients with stable joint damage...
January 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/25949042/acute-myocardial-infarction-and-coronary-artery-dissection-following-rugby-related-blunt-chest-trauma-in-france
#18
R Poyet, E Capilla, S Kerebel, F X Brocq, F Pons, C Jego, G R Cellarier
Coronary artery (CA) dissection following blunt chest trauma is a life-threatening and rare event. Its occurrence in the setting of a contact sport like rugby is even less common. We report on two cases of young adult presenting with segment elevation myocardial infarction related to CA dissection following rugby game. Both were successfully treated with stent implantation. We discuss the mechanism, diagnosis, and optimal management of blunt chest trauma-induced CA dissection.
April 2015: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/25931233/influence-of-roughness-and-tilt-on-nanoindentation-measurements-a-quantitative-model
#19
Mathilde Laurent-Brocq, Estelle Béjanin, Yannick Champion
A model, which takes into account the indentation size effect, was proposed to relate hardness and its standard deviation to the quality of the sample surface, i.e., the roughness and the tilt. Stainless steel samples were mechanically polished so as to obtain various roughness and tilt. Then the quality of the surface and the hardness were measured respectively by scanning probe microscopy and by nanoindentation. The model was fitted according to those experimental data. It was shown that the standard deviation only depends on the ratio of the arithmetic roughness over the contact depth of the indent while the average hardness also depends on the contact depth and on the tilt...
September 2015: Scanning
https://www.readbyqxmd.com/read/25191038/a-nonrandomized-study-of-trichoscopy-patterns-using-nonpolarized-contact-and-polarized-noncontact-dermatoscopy-in-hair-and-shaft-disorders
#20
Vivek V Nikam, Hita H Mehta
AIMS: The aim was to study the trichoscopy features of selected hair and scalp conditions by two dermoscopic devices with different modes that is, polarized (noncontact) and nonpolarized (contact) mode. MATERIALS AND METHODS: The present study included 11 clinical varieties of cases with total 112 patients, attending Sir Takhtasinh Hospital, Bhavnagar in the last 2 years. The clinical history was recorded for each case, and images were taken in both the Heine and DermLite II pro dermatoscope...
April 2014: International Journal of Trichology
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