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REVIEW
Sarah Nutter, Laura A Eggerichs, Taniya S Nagpal, Ximena Ramos Salas, Christine Chin Chea, Shubo Saiful, Johanna Ralston, Olivia Barata-Cavalcanti, Claudia Batz, Louise A Baur, Susie Birney, Sheree Bryant, Kent Buse, Michelle I Cardel, Aastha Chugh, Ada Cuevas, Mychelle Farmer, Allison Ibrahim, Ishu Kataria, Catherine Kotz, Ted Kyle, Sara le Brocq, Vicki Mooney, Clare Mullen, Joe Nadglowski, Margot Neveux, Karin Papapietro, Jaynaide Powis, Rebecca M Puhl, Bernardo Rea Ruanova, Jessica F Saunders, Fatima Cody Stanford, Ogweno Stephen, Kwang Wei Tham, Agbo Urudinachi, Lesly Vejar-Renteria, Danielle Walwyn, John Wilding, Saifullah Yusop
Weight stigma, defined as pervasive misconceptions and stereotypes associated with higher body weight, is both a social determinant of health and a human rights issue. It is imperative to consider how weight stigma may be impeding health promotion efforts on a global scale. The World Obesity Federation (WOF) convened a global working group of practitioners, researchers, policymakers, youth advocates, and individuals with lived experience of obesity to consider the ways that global obesity narratives may contribute to weight stigma...
January 2024: Obesity Reviews
#2
JOURNAL ARTICLE
Steven Kossard
Both parapsoriasis and LyP appear clinically as inflammatory dermatoses with a paradoxical link to cMF. A key element in addressing the relationship of parapsoriasis and MF were the results of the French and Dutch long-term registries tracking the emergence of lymphomas in the setting of LyP. Both cMF and cALCL emerged almost equally in these long-term studies. This ultimately supports that the stem cells in both cMF and cALCL are probably derived from a common stem cell shared by CD4+/CD8+ memory stem cells defining cMF and CD30+ stem cells defining cALCL...
November 1, 2023: American Journal of Dermatopathology
#3
JOURNAL ARTICLE
Samuel Bitoun, Signe Hässler, David Ternant, Natacha Szely, Aude Gleizes, Christophe Richez, Martin Soubrier, Jérome Avouac, Olivier Brocq, Jérémie Sellam, Niek de Vries, Tom W J Huizinga, Elizabeth C Jury, Jessica J Manson, Claudia Mauri, Andrea Matucci, Salima Hacein Bey Abina, Denis Mulleman, Marc Pallardy, Philippe Broët, Xavier Mariette
IMPORTANCE: There are conflicting data on the association of antidrug antibodies with response to biologic disease-modifying antirheumatic drugs (bDMARDs) in rheumatoid arthritis (RA). OBJECTIVE: To analyze the association of antidrug antibodies with response to treatment for RA. DESIGN, SETTING, AND PARTICIPANTS: This cohort study analyzed data from the ABI-RA (Anti-Biopharmaceutical Immunization: Prediction and Analysis of Clinical Relevance to Minimize the Risk of Immunization in Rheumatoid Arthritis Patients) multicentric, open, prospective study of patients with RA from 27 recruiting centers in 4 European countries (France, Italy, the Netherlands, and the UK)...
July 3, 2023: JAMA Network Open
#4
REVIEW
Migena Luli, Giles Yeo, Emma Farrell, Jane Ogden, Helen Parretti, Emma Frew, Stephen Bevan, Adrian Brown, Jennifer Logue, Vinod Menon, Nadya Isack, Michael Lean, Chris McEwan, Paul Gately, Simon Williams, Nerys Astbury, Maria Bryant, Kenneth Clare, Georgios K Dimitriadis, Graham Finlayson, Nicola Heslehurst, Brett Johnson, Sarah Le Brocq, Audrey Roberts, Patrick McGinley, Julia Mueller, Mary O'Kane, Rachel L Batterham, Alexander Dimitri Miras
Unlike various countries and organisations, including the World Health Organisation and the European Parliament, the United Kingdom does not formally recognise obesity as a disease. This report presents the discussion on the potential impact of defining obesity as a disease on the patient, the healthcare system, the economy, and the wider society. A group of speakers from a wide range of disciplines came together to debate the topic bringing their knowledge and expertise from backgrounds in medicine, psychology, economics, and politics as well as the experience of people living with obesity...
April 2023: EClinicalMedicine
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JOURNAL ARTICLE
Swati Bansal, Rajiv Jain, Virendra Budhiraja, Shveta Swami, Rimpi Gupta
Left coronary artery divides into anterior interventricular branch and circumflex branch. As both the arteries run in their corresponding grooves, an arteriovenous trigone is formed between conus arteriosus and left auricle called triangle of Brocq and Mouchet. The triangle base is formed by great cardiac vein. This study aims to describe the frequency of triangle and its type and relationship between various boundaries and content of triangle and to supplement the existing knowledge of clinicians. This observational and descriptive study was conducted on 40 formalin fixed cadaveric hearts in department of anatomy, Kalpana chawla government medical college...
April 13, 2023: Anatomy & Cell Biology
#6
JOURNAL ARTICLE
Shilpa A, Michelle S Fernandes, Ramesh M Bhat, Sukumar Dandakeri, Jyothi Jayaraman
Pyoderma gangrenosum is a rare neutrophilic inflammatory skin disorder commonly seen over lower limbs. Involvement of penile area is rare. We report this rare case of occurrence of ulcerative type of pyoderma gangrenosum over penis with pustular type elsewhere over the body, healing with keloids in an immunocompetent young man with no systemic associations.
October 11, 2022: International Journal of STD & AIDS
#7
JOURNAL ARTICLE
Emine Çölgeçen, Gözde Emel Gökçek, Sevinç Şahin
The purpose of this study was to assess how skin biopsy results from adults, which occupy an important place in dermatological practice, have been affected by the COVID-19 pandemic. Adult patients aged over 18 presenting to the dermatology clinical of a tertiary hospital between March 12, 2019 and March 11, 2020, and between March 12, 2020 and March 11, 2021, from whom skin biopsies had been taken and who had undergone pathological examination were included in the study. Pre-COVID-19 pandemic data were compared with post-pandemic data...
July 2022: Acta Dermatovenerologica Croatica: ADC
#8
JOURNAL ARTICLE
Sarah Le Brocq
No abstract text is available yet for this article.
September 2022: EClinicalMedicine
#9
JOURNAL ARTICLE
Paul Schmitt, Raphael Demoulin, Raphael Poyet, Eléonore Capilla, Gwénolé Rohel, Frédéric Pons, Christophe Jégo, Salimatou Sidibe, Thibaut Prevautel, Arnaud Druelle, François-Xavier Brocq, Gilles R Cellarier
Ibrutinib is a potent Bruton tyrosine kinase inhibitor and is an effective and well-tolerated treatment for a variety of lymphoid diseases. However, its use is associated with an increased incidence of atrial fibrillation ranging from 4% to 16%. New onset atrial fibrillation in cancer patients is associated with a significantly higher risk of heart failure and thromboembolism, even after adjusting for known risk factors. Ibrutinib also inhibits platelet activation and decisions regarding anticoagulation must be carefully weighed against this increased risk of bleeding...
September 14, 2022: Annales de Cardiologie et D'angéiologie
#10
JOURNAL ARTICLE
Atif A Hashmi, Khushbakht Rashid, Rubia Ali, Tanim Ud Dowlah, Abrahim H Ali, Muhammad Asad Diwan, Umair Arshad Malik, Muhammad Irfan, Shamail Zia, Adeel Ahmad
Introduction Alopecia is a common dermatological condition with varied etiologies based on age, gender and geographic location. Non-cicatricial (non-scarring) alopecia is more common but often not biopsied. Alternatively, primary cicatricial (scarring) alopecia is diagnostically more challenging and more commonly biopsied to determine the etiology. In this study, we evaluated the clinicopathological characteristics of alopecia in our population. Methods We conducted a retrospective study at the Department of Histopathology, Liaquat National Hospital and Medical College, Pakistan...
August 2022: Curēus
#11
JOURNAL ARTICLE
Matthew E Potter, J J M Le Brocq, A E Oakley, H Cavaye, Bart D Vandegehuchte, Robert Raja
Molecular interactions of hydrocarbons within the confined pores of heterogeneous catalysts can influence reaction pathways, which play a crucial role in determining the overall efficacy of catalytic transformations. We probe the interactions of n -butane with a solid-acid zeolite, mordenite, combining inelastic neutron scattering with DFT calculations. This reveals that the solid-acid sites within mordenite induce a conformer change, which could be key in designing optimised catalysts, for hydrocarbon transformations...
September 2, 2022: Chemical Communications: Chem Comm
#12
JOURNAL ARTICLE
Guillaume Labat, Meggy Hayotte, Laurent Bailly, Roxane Fabre, Olivier Brocq, Pauline Gerus, Véronique Breuil, Manuella Fournier-Mehouas, Raphaël Zory, Fabienne D'Arripe-Longueville, Christian H Roux
OBJECTIVE: To evaluate the impact of a wearable activity tracker used to encourage physical activity, on disease flares in spondyloarthritis patients. METHODS: This randomized controlled trial involved randomizing 108 spondyloarthritis patients into tracker and non-tracker groups. The participants were then subjected to assessments of disease activity, performance (6-Minute Walk Test), and quality of life (Short-Form-36 Health Survey Questionnaire) at the 12th , 24th , and 36th week...
June 15, 2022: Journal of Rheumatology
#13
JOURNAL ARTICLE
Claire E E de Vries, Caroline B Terwee, May Al Nawas, Bart A van Wagensveld, Ignace M C Janssen, Ronald S L Liem, Simon W Nienhuijs, Ricardo V Cohen, Elisabeth F C van Rossum, Wendy A Brown, Amir A Ghaferi, Johan Ottosson, Karen D Coulman, Tarissa B Z Petry, Stephanie Sogg, Lisa West-Smith, Jason C G Halford, Ximena Ramos Salas, John B Dixon, Salman Al-Sabah, Wei-Jei Lee, John Roger Andersen, Stuart W Flint, Maarten M Hoogbergen, Brooke Backman, Ellen Govers, Nadya Isack, Caroline Clay, Susie Birney, Maureen Gunn, Paul Masterson, Audrey Roberts, Jacky Nesbitt, Riccardo Meloni, Sarah le Brocq, Sandra de Blaeij, Christina Kraaijveld, Floor van der Steen, Bibian Visser, Petra Hamers, Valerie M Monpellier
Quality of life is a key outcome that is not rigorously measured in obesity treatment research due to the lack of standardization of patient-reported outcomes (PROs) and PRO measures (PROMs). The S.Q.O.T. initiative was founded to Standardize Quality of life measurement in Obesity Treatment. A first face-to-face, international, multidisciplinary consensus meeting was conducted to identify the key PROs and preferred PROMs for obesity treatment research. It comprised of 35 people living with obesity (PLWO) and healthcare providers (HCPs)...
August 2022: Obesity Reviews
#14
JOURNAL ARTICLE
Vasudha Kulkarni, Geethanjali Ht, Tejaswi H Lokanathan
Introduction In recent years, rapid developments in procedures like cardiac pacing, targeted drug therapy, and trans coronary venous ablation have necessitated a need for a detailed study of cardiac venous anatomy. Because the number, diameter, and course of the coronary veins vary, extensive information on the patient's specific anatomy is required for the best planning of the treatment. With this background, we planned the current research to analyze the anatomy of the great cardiac vein (GCV) in terms of length and diameter, provide a formula for calculating diameter using linear regression analysis and report the frequency of formation of the triangle of Brocq and Mouchet...
March 2022: Curēus
#15
JOURNAL ARTICLE
Pedro M Machado, Saskia Lawson-Tovey, Anja Strangfeld, Elsa F Mateus, Kimme L Hyrich, Laure Gossec, Loreto Carmona, Ana Rodrigues, Bernd Raffeiner, Catia Duarte, Eric Hachulla, Eric Veillard, Eva Strakova, Gerd R Burmester, Gözde Kübra Yardımcı, Jose A Gomez-Puerta, Julija Zepa, Lianne Kearsley-Fleet, Ludovic Trefond, Maria Cunha, Marta Mosca, Martina Cornalba, Martin Soubrier, Nicolas Roux, Olivier Brocq, Patrick Durez, Richard Conway, Tiphaine Goulenok, Johannes Wj Bijlsma, Iain B McInnes, Xavier Mariette
OBJECTIVES: To describe the safety of vaccines against SARS-CoV-2 in people with inflammatory/autoimmune rheumatic and musculoskeletal disease (I-RMD). METHODS: Physician-reported registry of I-RMD and non-inflammatory RMD (NI-RMDs) patients vaccinated against SARS-CoV-2. From 5 February 2021 to 27 July 2021, we collected data on demographics, vaccination, RMD diagnosis, disease activity, immunomodulatory/immunosuppressive treatments, flares, adverse events (AEs) and SARS-CoV-2 breakthrough infections...
May 2022: Annals of the Rheumatic Diseases
#16
REVIEW
Donna M Cummins, Iskander H Chaudhry, Matthew Harries
Primary cicatricial alopecias (PCA) represent a challenging group of disorders that result in irreversible hair loss from the destruction and fibrosis of hair follicles. Scalp skin biopsies are considered essential in investigating these conditions. Unfortunately, the recognised complexity of histopathologic interpretation is compounded by inadequate sampling and inappropriate laboratory processing. By sharing our successes in developing the communication pathway between the clinician, laboratory and histopathologist, we hope to mitigate some of the difficulties that can arise in managing these conditions...
November 24, 2021: Biomedicines
#17
JOURNAL ARTICLE
Paul Burgoyne, Alan J Hayes, Rachel S Cooper, Michelle L Le Brocq, Christopher Ah Hansell, John Dm Campbell, Gerard J Graham
Dendritic cell therapy has been a promising addition to the current armory of therapeutic options in cancer for more than 20 years but has not yet achieved breakthrough success. To successfully initiate immunity, dendritic cells have to enter the lymph nodes. However, experience to date of therapeutic dendritic cell administration indicates that this is frequently an extremely inefficient process. The major regulator of dendritic cell migration to the lymph nodes is the chemokine receptor CCR7 and in vitro generated dendritic cells typically display heterogeneous expression of this receptor...
November 15, 2021: Journal of Leukocyte Biology
#18
JOURNAL ARTICLE
P Schmitt, R Demoulin, R Poyet, E Capilla, G Rohel, F Pons, C Jégo, S Sidibe, A Druelle, F-X Brocq, F Dutasta, G R Cellarier
INTRODUCTION: The etiology of myocarditis often remains undetermined. A large variety of infectious agents, systemic diseases, drugs, and toxins can cause the disease. We report the case of a 19-year-old man who developed myocarditis three days after Pfizer-BioNTech COVID-19 booster vaccination. CASE REPORT: A 19-year-old man, presenting with troponin-positive acute chest pain, was referred to our department. He had received the Pfizer-BioNTech COVID-19 vaccine three days prior to his admission...
November 2021: La Revue de Médecine Interne
#19
JOURNAL ARTICLE
Emil Babić, Đuro Drobac, Ignacio Alejandro Figueroa, Mathilde Laurent-Brocq, Željko Marohnić, Vesna Mikšić Trontl, Damir Pajić, Loїc Perrière, Petar Pervan, Gyorgy Remenyi, Ramir Ristić, Amra Salčinović Fetić, Damir Starešinić, Krešo Zadro
The study of the transition from high-entropy alloys (HEAs) to conventional alloys (CAs) composed of the same alloying components is apparently important, both for understanding the formation of HEAs and for proper evaluation of their potential with respect to that of the corresponding CAs. However, this transition has thus far been studied in only two types of alloy systems: crystalline alloys of iron group metals (such as the Cantor alloy and its derivatives) and both amorphous (a-) and crystalline alloys, TE-TL, of early (TE = Ti, Zr, Nb, Hf) and late (TL = Co, Ni, Cu) transition metals...
October 5, 2021: Materials
#20
JOURNAL ARTICLE
Laëtitia Corgie, Nicolas Huiban, Frédéric Janvier, Chrystelle Darles, Francois-Xavier Brocq, Fabien Dutasta, Marc Monteil
OBJECTIVES: Sexually transmitted infections (STIs) can cause leukocyturia. We aimed to estimate the prevalence of leukocyturia in asymptomatic aircrews and the proportion of STIs in those presenting leukocyturia. METHODS: The LEUCO survey was a prospective cohort study conducted among aircrews between 14th October 2019 and 13th March 2020 at the Toulon aeromedical centre in France. All participants performed a dipstick urinalysis. Those positive for leukocyturia were offered STI screening by nucleic acid amplification test (NAAT) for Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium and Trichomonas vaginalis...
January 2022: Clinical Microbiology and Infection
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