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https://www.readbyqxmd.com/read/27904045/puerarin-prevents-lps-induced-osteoclast-formation-and-bone-loss-via-inhibition-of-akt-activation
#1
Yun Zhang, Ming Yan, Qing-Feng Yu, Pei-Fan Yang, Hai-Dong Zhang, Yong-Hong Sun, Zhi-Fen Zhang, Yun-Feng Gao
Osteolysis induced by chronic Gram-negative bacterial infection underlies many bone diseases such as osteomyelitis, septic arthritis, and periodontitis. Drugs that inhibit lipopolysaccharide (LPS)-induced osteolysis are critically needed for the prevention of bone destruction in infective bone diseases. In this study, we assessed the effect of puerarin, a natural isoflavone isolated from Pueraria lobata OHWI root, on LPS-induced osteoclastogenesis and bone loss. Our in vitro study showed that puerarin significantly inhibited LPS-induced osteoclast differentiation from osteoclast precursor RAW264...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27886150/improvement-of-transmembrane-transport-mechanism-study-of-imperatorin-on-p-glycoprotein-mediated-drug-transport
#2
Zheng-Gen Liao, Tao Tang, Xue-Jing Guan, Wei Dong, Jing Zhang, Guo-Wei Zhao, Ming Yang, Xin-Li Liang
P-glycoprotein (P-gp) affects the transport of many drugs; including puerarin and vincristine. Our previous study demonstrated that imperatorin increased the intestinal absorption of puerarin and vincristine by inhibiting P-gp-mediated drug efflux. However; the underlying mechanism was not known. The present study investigated the mechanism by which imperatorin promotes P-gp-mediated drug transport. We used molecular docking to predict the binding force between imperatorin and P-gp and the effect of imperatorin on P-gp activity...
November 24, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27844252/effect-of-puerarin-on-transcriptome-of-astrocyte-during-oxygen-glucose-deprivation-reoxygenation-injury
#3
Shuyong Wei, Jie Tong, Qiang Xue, Yang Liu, Xiaoyu Xu
Stroke is a serious disease with complex pathomechanism and limited therapeutic effect in clinic. Our previous research has found obvious therapeutic effect of Puerarin (Pur) on stroke injury of rat. The aim of this study is to investigate the transcriptome changes of oxygen-glucose deprivation/reoxygenation (OGD/R)-injured astrocytes before and after the intervention of Pur. Cells activity and apoptosis detection indicated that the activity of OGD/R-injured astrocytes was improved, and the apoptosis was ameliorated by Pur...
November 14, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27830026/puerarin-inhibits-cardiac-fibrosis-via-monocyte-chemoattractant-protein-mcp-1-and-the-transforming-growth-factor-%C3%AE-1-tgf-%C3%AE-1-pathway-in-myocardial-infarction-mice
#4
Zhiwen Tao, Yingbin Ge, Ningtian Zhou, Yunle Wang, Weili Cheng, Zhijian Yang
Transforming growth factor-β1 (TGF-β1) and inflammation play important roles in the cardiac fibrosis development associated with myocardial infarction (MI). Puerarin is wildly used for treatment of diabetes, cardiovascular disease and cerebrovascular disease in China, and recently some studies have shown its anti-cardiac fibrotic effect on myocardial hypertrophy. The purpose of our study was to determine whether puerarin has an anti-cardiac fibrotic effect after MI and find the potential mechanism. A mouse model of MI was established by standard LAD coronary artery ligation, and cardiac fibrosis was confirmed by Masson's staining and the expression of collagen I, III and α-SMA...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27808353/puerarin-prevents-inflammation-and-apoptosis-in-the-neurocytes-of-a-murine-parkinson-s-disease-model
#5
M Jiang, Q Yun, G Niu, Y Gao, F Shi, S Yu
The aim of this study was to investigate Parkinson's disease (PD) using a murine model of PD. Specifically, we aimed to explore the mechanism by which puerarin prevents inflammation and apoptosis in neurocytes. Eighty healthy male C57/BL6 mice were randomly selected and divided into four groups (N = 20 each): control group; PD group; PD+puerarin group; and puerarin group. At the end of the treatment period, the animals' brains were removed after perfusion and decollation. The protein expression levels of tyrosine hydroxylase (TH) in the murine brains were assessed by immunohistochemistry and the protein expression levels of TH, glial fibrillary acidic protein (GFAP), inducible nitric oxide synthase (iNOS), cleaved Caspase-3, and Bax in the substantia nigra and corpus striatum of the animals were assessed by western blotting...
October 5, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27807543/anticerebral-ischemia-reperfusion-injury-activity-of-synthesized-puerarin-derivatives
#6
Yubin Ji, Pei Jiang, Xinjia Yan
When cerebral ischemia-reperfusion injury happened in patients, multiple pathological processes occur, such as leukocyte infiltration, platelet, and complement activation, which would result in cognitive dysfunction and inflammation. Puerarin has shown protective effect on injury of neural cell. In order to enhance this protective effect of puerarin, puerarin derivatives with different log⁡P values were designed and synthesized. The original phenolic hydroxyl in the puerarin molecules was substituted in order to change the blood-brain barrier permeability and thus enhance the efficacy for preventing cerebral ischemia/reperfusion injury...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27797200/correction-to-protective-effects-of-genistein-and-puerarin-against-chronic-alcohol-induced-liver-injury-in-mice-via-antioxidant-anti-inflammatory-and-anti-apoptotic-mechanisms
#7
Liang Zhao, Yong Wang, Jia Liu, Kai Wang, Xiaoxuan Guo, Baoping Ji, Wei Wu, Feng Zhou
No abstract text is available yet for this article.
October 31, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27796870/gpr30-activation-contributes-to-the-puerarin-mediated-neuroprotection-in-mpp-induced-sh-sy5y-cell-death
#8
Yue-Fa Cheng, Guoqi Zhu, Qing-Wen Wu, Yue-Sheng Xie, Yan Jiang, Lan Guo, Ya-Li Guan, Ying-Shuo Liu, Jun Zhang
The neuroprotective action of puerarin in Parkinson's disease (PD) models has been well investigated. However, the mechanisms involved in protection have not been completely understood. G protein-coupled receptor 30 (GPR30) is a G protein-coupled estrogen receptor and considered a potential target in the neuroprotection against PD. In this study, we investigated whether puerarin prevented against 1-methyl-4-phenylpyridinium (MPP(+))-induced cell death via GPR30. Our results showed that the GPR30 agonist, G1, exhibited puerarin-mediated neuroprotection against MPP(+)-induced cell death of SH-SY5Y cells...
October 30, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27771118/puerarin-ameliorates-heat-stress-induced-oxidative-damage-and-apoptosis-in-bovine-sertoli-cells-by-suppressing-ros-production-and-upregulating-hsp72-expression
#9
Xia Cong, Qian Zhang, Huatao Li, Zhongling Jiang, Rongfeng Cao, Shansong Gao, Wenru Tian
Puerarin, a bioactive isoflavone glucoside extracted from radix Puerariae, has been proven to possess many biological activities. However, the role of puerarin in protecting bovine Sertoli cells (bSCs) under heat stress conditions remains to be clarified. The present study aimed to explore the possible protective mechanism of puerarin for primary cultured bSCs subjected to heat stress. Bovine Sertoli cells were treated with 15 μM of puerarin before they were exposed to 42 °C for 1 hour. The dose of puerarin (15 μM) was determined on the basis of cell viability...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27762461/restoration-of-autophagy-by-puerarin-in-lead-exposed-primary-rat-proximal-tubular-cells-via-regulating-ampk-mtor-signaling
#10
Xiangbin Song, Zifa Li, Fei Liu, Zhenyong Wang, Lin Wang
Previous study has demonstrated that puerarin (PU) exerts nephroprotective effect against Pb-induced cytotoxicity in primary rat proximal tubular (rPT) cells. Autophagy can protect cells from various cytotoxic stimuli, but its role in the process of PU against Pb-induced nephrotoxicity is still unknown. This study aims to investigate whether PU can alleviate Pb-induced renal damage by recovering autophagy. Data showed that Pb inhibited the autophagic flux, as evidenced by the accumulation of LC3-II and p62 as well as the confocal microscopy analysis of GFP-LC3 puncta and punctate spots of monodansylcadaverine staining, whereas coadministration of PU could restore Pb-induced autophagy inhibition...
October 20, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27762288/the-effects-of-puerarin-on-rat-ventricular-myocytes-and-the-potential-mechanism
#11
Hao Xu, Manxi Zhao, Shenghui Liang, Quanshu Huang, Yunchuan Xiao, Liang Ye, Qinyi Wang, Longmei He, Lanxiang Ma, Hua Zhang, Li Zhang, Hui Jiang, Xiao Ke, Yuchun Gu
Puerarin, a known isoflavone, is commonly found as a Chinese herb medicine. It is widely used in China to treat cardiac diseases such as angina, cardiac infarction and arrhythmia. However, its cardioprotective mechanism remains unclear. In this study, puerarin significantly prolonged ventricular action potential duration (APD) with a dosage dependent manner in the micromolar range on isolated rat ventricular myocytes. However, submicromolar puerarin had no effect on resting membrane potential (RMP), action potential amplitude (APA) and maximal velocity of depolarization (Vmax) of action potential...
October 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27717903/an-isoflavonoid-enriched-extract-from-pueraria-lobata-kudzu-root-protects-human-umbilical-vein-endothelial-cells-against-oxidative-stress-induced-apoptosis
#12
Ying Gao, Xu Wang, Chunnian He
ETHNOPHARMACOLOGICAL RELEVANCE: Reactive oxygen species (ROS) mediate vascular cell dysfunction and lead to atherosclerosis and other chronic cardiovascular diseases. The root of Pueraria lobata (Willd.) Ohwi, also known as kudzu or Gegen (Chinese name), is one of the most important herbs in traditional Chinese medicine and has been widely used in the treatment of cardiovascular diseases, diabetes, osteonecrosis and neurodegradation diseases. In this study, an ethanol extract from kudzu root was prepared and the in vitro protective effect of the kudzu root extract (KUD) on human umbilical vein endothelial cells (HUVECs) was investigated...
October 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27717697/puerarin-protects-against-cadmium-induced-proximal-tubular-cell-apoptosis-by-restoring-mitochondrial-function
#13
Xiang-Bin Song, Gang Liu, Zhen-Yong Wang, Lin Wang
Puerarin (PU) is a potent free radical scavenger with a protective effect in nephrotoxin-mediated oxidative damage. Here, we show a novel molecular mechanism by which PU exerts its anti-apoptotic effects in cadmium (Cd)-exposed primary rat proximal tubular (rPT) cells. Morphological assessment and flow cytometric analysis revealed that PU significantly decreased Cd-induced apoptotic cell death of rPT cells. Administration of PU protected cells against Cd-induced depletion of mitochondrial membrane potential (ΔΨm) and lipid peroxidation...
October 4, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27708724/retraction-notice-research-on-the-effect-of-puerarin-on-alleviating-sports-fatigue
#14
Zhang Wei
No abstract text is available yet for this article.
2016: Open Biomedical Engineering Journal
https://www.readbyqxmd.com/read/27698763/observation-on-therapeutic-efficacy-of-rt-pa-intravenous-thrombolysis-combined-with-compound-anisodine-injection-on-central-retinal-artery-occlusion
#15
Xiao-Jun Wu, Feng Gao, Xu Liu, Qing Zhao
The aim of the present study was to observe the clinical efficacy and safety of recombinant tissue plasminogen activator (rt-PA) combined with compound anisodine in treating central retinal artery occlusion (CRAO). Forty-eight patients diagnosed with CRAO were randomly divided into a treatment group (24 cases) and a control group (24 cases). For the control group, nitroglycerin, 654-2, methazolamide, puerarin and compound anisodine were used for the treatment, along with oxygen, massage and other conventional treatments...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27697446/coadministration-of-puerarin-low-dose-and-zinc-attenuates-bone-loss-and-suppresses-bone-marrow-adiposity-in-ovariectomized-rats
#16
Hao Liu, Wei Li, Xiyuan Ge, Shengnan Jia, Binbin Li
AIMS: Puerarin is a phytoestrogen that shows osteogenic effects. Meanwhile, zinc stimulates bone formation and inhibits bone resorption. The study aims to investigate the effects of coadministration of puerarin (low dose) and zinc on bone formation in ovariectomized rats. MATERIALS AND METHODS: Co-administration or use alone of puerarin (low dose) and/or zinc were gavaged in OVX rats. The estrogen-like effects were detected by the uterus weight, the histologic observation and the IGF-1 protein expression...
September 29, 2016: Life Sciences
https://www.readbyqxmd.com/read/27677221/puerarin-exerts-the-protective-effect-against-chemical-induced-dysmetabolism-in-rats
#17
Rong Li, Jianhua Song, Wei Wu, Xinmou Wu, Min Su
In this study, we aim to explore the potential benefits of puerarin on metabolic function of liver fibrosis (LF) rat induced by carbon tetrachloride (CCl4), and to investigate with the underlying molecular mechanism targeted on liver and pancreas tissues. In methodology, The LF rats were prepared through intragastrically giving CCl4 twice each week (2ml/kg, v/w) for 8weeks, and dosed puerarin (20, 40mg/kg) were given three times each week via intraperitoneal injection. After being conducted with oral glucose tolerance test (OGTT), the blood samples of rat were harvested for biochemical tests, as well as the liver and pancreas were isolated for histological examination and biochemical assays...
September 24, 2016: Gene
https://www.readbyqxmd.com/read/27659301/anti-ageing-active-ingredients-from-herbs-and-nutraceuticals-used-in-traditional-chinese-medicine-pharmacological-mechanisms-and-implications-for-drug-discovery
#18
REVIEW
Chun-Yan Shen, Jian-Guo Jiang, Li Yang, Da-Wei Wang, Wei Zhu
Ageing, an unanswered question in the medical field, is a multifactorial process that results in a progressive functional decline in cells, tissues and organisms. Although it is impossible to prevent ageing, slowing down the rate of ageing is entirely possible to achieve. Traditional Chinese medicine (TCM) is characterized by the nourishing of life and its role in anti-ageing is getting more and more attention. This article summarizes the work done on the natural products from TCM that are reported to have anti-ageing effects, in the past two decades...
September 23, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27650591/simultaneous-determination-of-epalrestat-and-puerarin-in-rat-plasma-by-uhplc-ms-ms-application-to-their-pharmacokinetic-interaction-study
#19
Hong Sun, Yunhai Bo, Mingjie Zhang, Xiao Wu, Mingyang Zhou, Longshan Zhao, Zhili Xiong
In the present work, a simple, rapid and reliable ultra high performance liquid chromatography -tandem mass spectrometric (UHPLC-MS/MS) method was developed and validated to simultaneously determine epalrestat (EPA) and puerarin (PUE) in rat plasma for evaluation the pharmacokinetic interaction of this two drugs. Both the analytes and glipizide (IS) were extracted using protein precipitation method. The separation was performed on C18 reversed phase column using acetonitrile and 5 mmol/L ammonium acetate in water as mobile phase with a gradient elution program...
September 21, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27643664/protective-effects-of-puerarin-on-acute-lung-and-cerebrum-injury-induced-by-hypobaric-hypoxia-via-the-regulation-of-aquaporin-aqp-via-nf-%C3%AE%C2%BAb-signaling-pathway
#20
Chi Wang, Muyang Yan, Hui Jiang, Qi Wang, Xu Guan, Jingwen Chen, Chengbin Wang
OBJECTIVE: Hypobaric hypoxia, frequently encountered at high altitude, may lead to lung and cerebrum injury. Our study aimed to investigate whether puerarin could exert ameliorative effects on rats exposed to hypobaric hypoxia via regulation of aquaporin (AQP) and NF-κB signaling pathway in lung and cerebrum. MATERIALS AND METHODS: 40 Sprague Dawley rats were divided into four groups (normal control group, hypobaric hypoxia group, puerarin group and dexamethasone group)...
September 16, 2016: International Immunopharmacology
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