Sylvain Harquel, Andéol Cadic-Melchior, Takuya Morishita, Lisa Fleury, Adrien Witon, Martino Ceroni, Julia Brügger, Nathalie H Meyer, Giorgia G Evangelista, Philip Egger, Elena Beanato, Pauline Menoud, Dimitri Van de Ville, Silvestro Micera, Olaf Blanke, Bertrand Léger, Jan Adolphsen, Caroline Jagella, Christophe Constantin, Vincent Alvarez, Philippes Vuadens, Jean-Luc Turlan, Andreas Mühl, Christophe Bonvin, Philipp J Koch, Maximilian J Wessel, Friedhelm C Hummel
BACKGROUND: Cortical excitation/inhibition dynamics have been suggested as a key mechanism occurring after stroke. Their supportive or maladaptive role in the course of recovery is still not completely understood. Here, we used transcranial magnetic stimulation (TMS)-electroencephalography coupling to study cortical reactivity and intracortical GABAergic inhibition, as well as their relationship to residual motor function and recovery longitudinally in patients with stroke. METHODS: Electroencephalography responses evoked by TMS applied to the ipsilesional motor cortex were acquired in patients with stroke with upper limb motor deficit in the acute (1 week), early (3 weeks), and late subacute (3 months) stages...
April 19, 2024: Stroke; a Journal of Cerebral Circulation