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https://www.readbyqxmd.com/read/29221791/online-effects-of-transcranial-direct-current-stimulation-on-prefrontal-metabolites-in-gambling-disorder
#1
Maya Dickler, Christophe Lenglos, Emmanuelle Renauld, Francine Ferland, Richard A Edden, Jean Leblond, Shirley Fecteau
Gambling disorder is characterized by persistent maladaptive gambling behaviors and is now considered among substance-related and addictive disorders. There is still unmet therapeutic need for these clinical populations, however recent advances indicate that interventions targeting the Glutamatergic/GABAergic system hold promise in reducing symptoms in substance-related and addictive disorders, including gambling disorder. There is some data indicating that transcranial direct current stimulation may hold clinical benefits in substance use disorders and modulate levels of brain metabolites including glutamate and GABA...
December 5, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29220866/neural-correlates-of-fatigue-in-multiple-sclerosis-a-combined-neurophysiological-and-neuroimaging-approach-r1
#2
M Russo, A Calamuneri, A Cacciola, L Bonanno, A Naro, V Dattola, E Sessa, M Buccafusca, D Milardi, P Bramanti, R S Calabrò, A Quartarone
The present study is aimed at further exploring structural and functional correlates of fatigue in Relapsing- Remitting Multiple Sclerosis (RRMS) patients by using a combined approach by means of transcranial magnetic stimulation (TMS) and a Diffusion Tensor Imaging (DTI). The physiopathology of fatigue in MS is still poorly understood, although a variety of pathogenic mechanisms has been proposed. Our working hypothesis is that diffuse microstructural white matter damage may subtend the cortico-subcortical functional disconnection described in patients with MS and fatigue...
September 30, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29215464/difference-in-phase-modulation-of-corticospinal-excitability-during-the-observation-of-the-action-of-walking-with-and-without-motor-imagery
#3
Naotsugu Kaneko, Yohei Masugi, Hikaru Yokoyama, Kimitaka Nakazawa
The aim of the current study was to clarify how corticospinal excitability (CSE) is modulated during the observation of the action of walking, combined with motor imagery (MI). We examined the difference in phase modulation of CSE with and without MI during the observation of the action of walking. We measured motor-evoked potentials in tibialis anterior and soleus muscles using transcranial magnetic stimulation under the following conditions: (1) baseline, (2) action observation (AO), and (3) AO and MI. Our results showed that, compared with AO alone, AO and MI of walking increased motor-evoked potentials...
December 5, 2017: Neuroreport
https://www.readbyqxmd.com/read/29214483/psychotherapyplus-augmentation-of-cognitive-behavioral-therapy-cbt-with-prefrontal-transcranial-direct-current-stimulation-tdcs-in-major-depressive-disorder-study-design-and-methodology-of-a-multicenter-double-blind-randomized-placebo-controlled-trial
#4
Malek Bajbouj, Sabine Aust, Jan Spies, Ana-Lucia Herrera-Melendez, Sarah V Mayer, Maike Peters, Christian Plewnia, Andreas J Fallgatter, Lukas Frase, Claus Normann, Nora Behler, Linda Wulf, Eva-Lotta Brakemeier, Frank Padberg
Major Depressive Disorder (MDD) is one of the most prevalent psychiatric disorders worldwide. About 20-30% of patients do not respond to the standard psychopharmacological and/or psychotherapeutic interventions. Mounting evidence from neuroimaging studies in MDD patients reveal altered activation patterns in lateral prefrontal brain areas. Successful cognitive behavioral therapy (CBT) is associated with a recovery of these neural alterations. Moreover, it has been demonstrated that transcranial direct current stimulation (tDCS) is capable of influencing prefrontal cortex activity and cognitive functions such as working memory and emotion regulation...
December 6, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29214399/preservation-of-motor-maps-with-increased-motor-evoked-potential-amplitude-threshold-in-rmt-determination
#5
Giuseppe Lucente, Steven Lam, Heike Schneider, Thomas Picht
OBJECTIVE: Non-invasive pre-surgical mapping of eloquent brain areas with navigated transcranial magnetic stimulation (nTMS) is a useful technique linked to the improvement of surgical planning and patient outcomes. The stimulator output intensity and subsequent resting motor threshold determination (rMT) are based on the motor-evoked potential (MEP) elicited in the target muscle with an amplitude above a predetermined threshold of 50 μV. However, a subset of patients is unable to achieve complete relaxation in the target muscles, resulting in false positives that jeopardize mapping validity with conventional MEP determination protocols...
December 6, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29213090/evaluation-of-short-interval-cortical-inhibition-and-intracortical-facilitation-from-the-dorsolateral-prefrontal-cortex-in-patients-with-schizophrenia
#6
Yoshihiro Noda, Mera S Barr, Reza Zomorrodi, Robin F H Cash, Faranak Farzan, Tarek K Rajji, Robert Chen, Zafiris J Daskalakis, Daniel M Blumberger
GABAergic and glutamatergic dysfunction in the dorsolateral prefrontal cortex (DLPFC) are thought to be the core pathophysiological mechanisms of schizophrenia. Recently, we have established a method to index these functions from the DLPFC using the paired transcranial magnetic stimulation (TMS) paradigms of short interval intracortical inhibition (SICI) and facilitation (ICF) combined with electroencephalography (EEG). In this study, we aimed to evaluate neurophysiological indicators related to GABAA and glutamate receptor-mediated functions respectively from the DLPFC in patients with schizophrenia using these paradigms, compared to healthy controls...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212923/response-inhibition-activates-distinct-motor-cortical-inhibitory-processes
#7
John Cirillo, Matthew J Cowie, Hayley J MacDonald, Winston D Byblow
We routinely cancel pre-planned movements that are no longer required. If stopping is forewarned, proactive processes are engaged to selectively decrease motor cortex excitability. However, without advance information there is a non-selective reduction in motor cortical excitability. Here we examine modulation of human primary motor cortex inhibitory networks during response inhibition tasks with informative and uninformative cues using paired-pulse transcranial magnetic stimulation. Long- and short-interval intracortical inhibition (LICI and SICI), indicative of GABAB- and GABAA-receptor mediated inhibition respectively, were examined from motor evoked potentials obtained in task-relevant and task-irrelevant hand muscles when response inhibition was preceded by informative and uninformative cues...
December 6, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29211865/the-impact-of-diffusion-tensor-imaging-fiber-tracking-of-the-corticospinal-tract-based-on-navigated-transcranial-magnetic-stimulation-on-surgery-of-motor-eloquent-brain-lesions
#8
Giovanni Raffa, Alfredo Conti, Antonino Scibilia, Salvatore Massimiliano Cardali, Felice Esposito, Filippo Flavio Angileri, Domenico La Torre, Carmela Sindorio, Rosaria Viola Abbritti, Antonino Germanò, Francesco Tomasello
BACKGROUND: Navigated transcranial magnetic stimulation (nTMS) enables preoperative mapping of the motor cortex (M1). The combination of nTMS with diffusion tensor imaging fiber tracking (DTI-FT) of the corticospinal tract (CST) has been described; however, its impact on surgery of motor-eloquent lesions has not been addressed. OBJECTIVE: To analyze the impact of nTMS-based mapping on surgery of motor-eloquent lesions. METHODS: In this retrospective case-control study, we reviewed the data of patients operated for suspected motor-eloquent lesions between 2012 and 2015...
November 29, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29208533/assessing-cerebellar-brain-inhibition-cbi-via-transcranial-magnetic-stimulation-tms-a-systematic-review
#9
REVIEW
Lara Fernandez, Brendan P Major, Wei-Peng Teo, Linda K Byrne, Peter G Enticott
The inhibitory tone that the cerebellum exerts on the primary motor cortex (M1) is known as cerebellar brain inhibition (CBI). Studies show CBI to be relevant to several motor functions, including adaptive motor learning and muscle control. CBI can be assessed noninvasively via transcranial magnetic stimulation (TMS) using a double-coil protocol. Variability in parameter choice and controversy surrounding the protocol's ability to isolate the cerebellothalamocortical pathway casts doubt over its validity in neuroscience research...
December 2, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29198860/comparative-of-transcranial-magnetic-stimulation-and-other-treatments-in-experimental-autoimmune-encephalomyelitis
#10
Francisco J Medina-Fernandez, Begoña M Escribano, Evelio Luque, Javier Caballero-Villarraso, Jose L Gomez-Chaparro, Montserrat Feijoo, Fe I Garcia-Maceira, Alvaro Pacual-Leone, René Drucker-Colin, Isaac Tunez
The effects of transcranial magnetic stimulation (TMS), natalizumab (nata), dimethyl fumarate (DMF) and dexamethasone (DEX) on clinical score and oxidative stress produced by a single dose of myelin oligodendrocyte glycoprotein (MOG) in tail of Dark Agouti rats was studied. TMS (60Hz and 0.7 mT), nata (5mg/kg), DMF (15mg/kg) and DEX (300μg/kg) was applied for 21 after the administration of MOG (150μg). We estimated clinical score, as well as lipid peroxides, carbonylated proteins and reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio content in brain, spinal cord and blood...
December 1, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29196322/a-new-high-efficacy-non-invasive-transcranial-electric-stimulation-tuned-to-local-neurodynamics
#11
Carlo Cottone, Andrea Cancelli, Patrizio Pasqualetti, Camillo Porcaro, Carlo Salustri, Franca Tecchio
In this paper, we pose the following working hypothesis: in humans, transcranial electric stimulation (tES) with a time course that mimics the endogenous activity of its target is capable of altering the target's excitability. In our case, the target was the primary motor cortex (M1). We identified the endogenous neurodynamics of hand M1's subgroups of pyramidal neuronal pools in each of our subjects by applying Functional Source Separation (FSS) to their electroencephalographic (EEG) recordings. We then tested whether the cortico-spinal excitability of the hand representation under the above described stimulation, which we named transcranial Individual neuroDynamics Stimulation (tIDS), was higher than in the absence of stimulation (baseline)...
December 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29195744/discrimination-of-atypical-parkinsonisms-with-transcranial-magnetic-stimulation
#12
Alberto Benussi, Valentina Dell'Era, Valentina Cantoni, Clarissa Ferrari, Salvatore Caratozzolo, Luca Rozzini, Antonella Alberici, Alessandro Padovani, Barbara Borroni
BACKGROUND: Differential diagnosis of atypical parkinsonian disorders, i.e. dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) or corticobasal syndrome (CBS) still remains problematic. Furthermore, DLB may overlap with Alzheimer's disease (AD) in the early stages of disease. OBJECTIVE: To determine whether transcranial magnetic stimulation (TMS) can be used to classify atypical parkinsonian disorders and AD. METHODS: A paired-pulse TMS multi-paradigm approach assessing multiple intracortical circuits, as short interval intracortical inhibition-facilitation and short latency afferent inhibition, was used to model a decision tree analysis and determine diagnostic accuracy in classifying different neurodegenerative disorders...
November 22, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29195158/corticospinal-excitability-during-motor-imagery-is-reduced-in-young-adults-with-developmental-coordination-disorder
#13
C Hyde, I Fuelscher, J Williams, J A G Lum, J He, P Barhoun, P G Enticott
While a compelling body of behavioral research suggests that individuals with developmental coordination disorder (DCD) experience difficulties engaging motor imagery (MI), very little is known about the neural correlates of this deficit. Since corticospinal excitability is a predictor of MI proficiency in healthy adults, we reasoned that decreased MI efficiency in DCD may be paralleled by atypical primary motor cortex (PMC) activity. Participants were 29 young adults aged 18- 36 years: 8 with DCD (DCD) and 21 controls...
November 28, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29191478/repetitive-transcranial-magnetic-stimulation-over-dorsolateral-prefrontal-cortex-modulates-value-based-learning-during-sequential-decision-making
#14
Lennart Wittkuhn, Ben Eppinger, Lea M Bartsch, Franka Thurm, Franziska M Korb, Shu-Chen Li
Adaptive behavior in daily life often requires the ability to acquire and represent sequential contingencies between actions and the associated outcomes. Although accumulating evidence implicates the role of dorsolateral prefrontal cortex (dlPFC) in complex value-based learning and decision-making, direct evidence for involvements of this region in integrating information across sequential decision states is still scarce. Using a 3-stage deterministic Markov decision task, here we applied offline, inhibitory low-frequency 1-Hz repetitive transcranial magnetic stimulation (rTMS) over the left dlPFC in young male adults (n = 31, mean age = 23...
November 27, 2017: NeuroImage
https://www.readbyqxmd.com/read/29191439/effects-of-cerebellar-neuromodulation-in-movement-disorders-a%C3%A2-systematic-review
#15
REVIEW
Carina França, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Ricardo Galhardoni, Valquiria Silva, Egberto Reis Barbosa, Rubens Gisbert Cury
BACKGROUND: The cerebellum is involved in the pathophysiology of many movement disorders and its importance in the field of neuromodulation is growing. OBJECTIVES: To review the current evidence for cerebellar modulation in movement disorders and its safety profile. METHODS: Eligible studies were identified after a systematic literature review of the effects of cerebellar modulation in cerebellar ataxia, Parkinson's disease (PD), essential tremor (ET), dystonia and progressive supranuclear palsy (PSP)...
November 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29191438/real-time-eeg-defined-excitability-states-determine-efficacy-of-tms-induced-plasticity-in-human-motor-cortex
#16
Christoph Zrenner, Debora Desideri, Paolo Belardinelli, Ulf Ziemann
BACKGROUND: Rapidly changing excitability states in an oscillating neuronal network can explain response variability to external stimulation, but if repetitive stimulation of always the same high- or low-excitability state results in long-term plasticity of opposite direction has never been explored in vivo. OBJECTIVE/HYPOTHESIS: Different phases of the endogenous sensorimotor μ-rhythm represent different states of corticospinal excitability, and repetitive transcranial magnetic stimulation (rTMS) of always the same high- vs...
November 24, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29190225/varied-antidepressant-response-and-subjective-experience-across-3-different-repetitive-transcranial-magnetic-stimulation-devices-a-case-report
#17
Carter Paul, Alvaro Pascual-Leone, Adam P Stern
No abstract text is available yet for this article.
December 2017: Journal of ECT
https://www.readbyqxmd.com/read/29189190/role-of-repetitive-transcranial-magnetic-stimulation-rtms-in-treatment-of-addiction-and-related-disorders-a-systematic-review
#18
Ramkrishna Makani, Basant Pradhan, Umang Shah, Tapan Parikh
BACKGROUND: Addiction and related disorders are devastating with their tremendous social, psychological, and physical consequences for which development of optimally effective treatments are long overdue. Repetitive transcranial magnetic stimulation (rTMS) is relatively safe and is becoming an emerging therapeutic tool for these conditions. METHODS: This systematic review was conducted using PubMed, PsycINFO, PsychiatryOnline and Cochrane Library ranging from year 2001 to 2017...
November 29, 2017: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/29187320/progressive-practice-promotes-motor-learning-and-repeated-transient-increases-in-corticospinal-excitability-across-multiple-days
#19
L Christiansen, M J Madsen, E Bojsen-Møller, R Thomas, J B Nielsen, J Lundbye-Jensen
BACKGROUND: A session of motor skill learning is accompanied by transient increases in corticospinal excitability(CSE), which are thought to reflect acute changes in neuronal connectivity associated with improvements in sensorimotor performance. Factors influencing changes in excitability and motor skill with continued practice remain however to be elucidated. OBJECTIVE/HYPOTHESIS: Here we investigate the hypothesis that progressive motor practice during consecutive days can induce repeated transient increases in corticospinal excitability and promote motor skill learning...
November 13, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29186189/modulation-of-corticospinal-output-in-agonist-and-antagonist-proximal-arm-muscles-during-motor-preparation
#20
Cécilia Neige, Hugo Massé-Alarie, Martin Gagné, Laurent J Bouyer, Catherine Mercier
Previous studies have shown modulation of corticospinal output of the agonist muscle when a known-movement is prepared but withheld until a response signal appearance, reflecting motor preparation processes. However, modulation in the antagonist muscles has not been described, despite the fact that reaching movements require precise coordination between the activation of agonist and antagonist muscles. In this study, participants performed an instructed-delay reaction time (RT) task, with randomized elbow flexion and extension movements...
2017: PloS One
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