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https://www.readbyqxmd.com/read/28814908/pulmonary-cryptococcosis-presenting-with-lung-mass-report-of-7-cases-and-review-of-literature
#1
Kanet Kanjanapradit, Zdravko Kosjerina, Wiwatana Tanomkiat, Warangkana Keeratichananont, Siripen Panthuwong
Pulmonary cryptococcosis is commonly found in immunocompromised patients. This microorganism rarely infects immunocompetent individuals, and when it does, it causes mild symptoms. The radiological findings of this disease may involve an intrapulmonary mass that mimics lung tumor. The objective of this study was to review the clinicopathological information, radiological findings, and treatment of patients who presented with intrapulmonary mass due to cryptococcosis. This study collected data from 7 patients who were treated at Songklanagarind Hospital, Songkhla, Thailand, between 2009 and 2014...
2017: Clinical Medicine Insights. Pathology
https://www.readbyqxmd.com/read/28814218/diagnosis-and-management-of-pancreatic-exocrine-insufficiency
#2
Mehrdad Nikfarjam, Jeremy S Wilson, Ross C Smith
In 2015, the Australasian Pancreatic Club (APC) published the Australasian guidelines for the management of pancreatic exocrine insufficiency (http://pancreas.org.au/2016/01/pancreatic-exocrine-insufficiency-guidelines). Pancreatic exocrine insufficiency (PEI) occurs when normal digestion cannot be sustained due to insufficient pancreatic digestive enzyme activity. This may be related to a breakdown, at any point, in the pancreatic digestive chain: pancreatic stimulation; synthesis, release or transportation of pancreatic enzymes; or synchronisation of secretions to mix with ingested food...
August 21, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28811999/quantitative-analysis-of-epicardial-fat-volume-effects-of-scanning-protocol-and-reproducibility-of-measurements-in-non-contrast-cardiac-ct-vs-coronary-ct-angiography
#3
Luigia D'Errico, Francesco Salituri, Marco Ciardetti, Riccardo Favilla, Alessandro Mazzarisi, Giuseppe Coppini, Carlo Bartolozzi, Paoli Marraccini
BACKGROUND: Several studies have focused on the role of epicardial fat in the pathogenesis of cardiovascular disease (CVD). The main purpose of the study was to evaluate a computerized method for the quantitative analysis of epicardial fat volume (EFV) by non-contrast cardiac CT (NCT) for coronary calcium scan and coronary CT angiography (coronary CTA). METHODS: Thirty patients (61±12.5 years, 73% male, body mass index (BMI) =25.9±6.3 kg/m(2)) referred to our Institution for suspected coronary artery disease (CAD) underwent NCT and coronary CTA...
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28811695/pai-1-study-in-thalassemia-major-patients-receiving-multiple-blood-transfusion
#4
Ashwini Kumar, H S Batra, Mithu Banerjee, S Bandyopadhyay, T K Saha, Pratibha Misra, Vivek Ambade
Thalassemia is a congenital hemolytic disease which is treated by repeated blood transfusion. Chronic iron overload is currently considered to be the primary cause of mortality in β-thalassemia, mainly due to the induction of left-sided cardiac failure. Iron overload results from a number of mechanisms associated with the disease itself. In addition to chronic iron overload thalassemic patients are more prone for procoagulant status which in turn lead to clinical thrombotic events. The hypercoagulable state in thalassemia is due to multiple elements, a combination of which is often the drive behind a clinical thromboembolic events...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28808947/the-sydney-heart-bank-improving-translational-research-while-eliminating-or-reducing-the-use-of-animal-models-of-human-heart-disease
#5
REVIEW
C G Dos Remedios, S P Lal, A Li, J McNamara, A Keogh, P S Macdonald, R Cooke, E Ehler, R Knöll, S B Marston, J Stelzer, H Granzier, C Bezzina, S van Dijk, F De Man, G J M Stienen, J Odeberg, F Pontén, W Linke, J van der Velden
The Sydney Heart Bank (SHB) is one of the largest human heart tissue banks in existence. Its mission is to provide high-quality human heart tissue for research into the molecular basis of human heart failure by working collaboratively with experts in this field. We argue that, by comparing tissues from failing human hearts with age-matched non-failing healthy donor hearts, the results will be more relevant than research using animal models, particularly if their physiology is very different from humans. Tissue from heart surgery must generally be used soon after collection or it significantly deteriorates...
August 14, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28808494/severe-fibrosing-mediastinitis-with-atypical-presentation-effective-control-with-novel-therapeutic-approach
#6
Abdulaziz Uthman Joury, Ahmad Amer Al Boukai, Tarek Seifaw Kashour
Fibrosing mediastinitis (FM), also known as sclerosing mediastinitis, is an uncommon but serious disease involving the mediastinal structures. A high index of suspicion is essential to establish the diagnosis of FM and starting the appropriate therapy for patients. Here, we report a case of a young female who presented with chest symptoms and subsequently underwent different laboratory and radiologic investigations and an excisional biopsy. The findings of these investigations were consistent with the diagnosis of idiopathic FM...
July 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28799701/drug-eluting-stents-versus-coronary-artery-bypass-grafting-for-left-main-coronary-artery-disease
#7
Hisato Takagi, Tomo Ando, Takuya Umemoto
OBJECTIVES: To compare follow-up outcomes after percutaneous coronary intervention with drug-eluting stents (DES-PCI) versus coronary artery bypass grafting (CABG) for left-main coronary artery disease (LMCAD), we performed a meta-analysis of randomized controlled trials (RCTs) and observational studies with propensity-score analysis. METHODS: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched through November 2016. Eligible studies were RCTs or observational studies with propensity-score analysis of DES-PCI versus CABG enrolling patients with LMCAD and reporting ≥ 6-month mortality, myocardial infarction (MI), stroke, or repeat revascularization (RRV)...
August 11, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28798024/fabry-disease-in-families-with-hypertrophic-cardiomyopathy-clinical-manifestations-in-the-classic-and-later-onset-phenotypes
#8
Berglind Adalsteinsdottir, Runolfur Palsson, Robert J Desnick, Marianna Gardarsdottir, Polakit Teekakirikul, Martin Maron, Evan Appelbaum, Ulf Neisius, Barry J Maron, Michael A Burke, Brenden Chen, Silvere Pagant, Christoffer V Madsen, Ragnar Danielsen, Reynir Arngrimsson, Ulla Feldt-Rasmussen, Jonathan G Seidman, Christine E Seidman, Gunnar Th Gunnarsson
BACKGROUND: The screening of Icelandic patients clinically diagnosed with hypertrophic cardiomyopathy resulted in identification of 8 individuals from 2 families with X-linked Fabry disease (FD) caused by GLA(α-galactosidase A gene) mutations encoding p.D322E (family A) or p.I232T (family B). METHODS AND RESULTS: Familial screening of at-risk relatives identified mutations in 16 family A members (8 men and 8 heterozygotes) and 25 family B members (10 men and 15 heterozygotes)...
August 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28795902/rhabdomyosarcoma-of-the-breast-report-of-a-rare-malignancy
#9
Yufen Yuan, Junna Hou, Yunbao Pan
Rhabdomyosarcoma (RMS) is an uncommon type of soft-tissue malignancy which mainly influences children. RMS rarely occurs in breast and little of the clinical behavior and treatment strategies were reported. Here, we describe a case of adult female patient with breast RMS. A 34-years-old Chinese woman visited to our hospital complaining palpable mass in her left breast. Seven months ago, the patient was diagnosed as lymphocytic mastitis and received surgical excision in the left breast. Five months later, she noticed a palpable mass again in the left breast...
August 10, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28795296/current-trends-in-selection-of-conduits-for-coronary-artery-bypass-grafting
#10
REVIEW
Thierry Carrel, Bernhard Winkler
The procedure of coronary artery bypass grafting continues to be the "gold standard" for patients with multivessel coronary artery disease and left main stenosis due to favourable long-term and consistent outcomes despite the advent of new generations of stents. But the targeted better long-term outcome of surgical revascularization over percutaneous interventions depends on several variables and aspects; one of them is the choice of conduits used to bypass the stenosed arteries. Coronary artery bypass surgery has been studied and debated for decades and the same applies to the selection of grafts...
August 9, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28790123/prognostic-significance-of-nonobstructive-left-main-coronary-artery-disease-in-women-versus-men-long-term-outcomes-from-the-confirm-coronary-ct-angiography-evaluation-for-clinical-outcomes-an-international-multicenter-registry
#11
Joe X Xie, Parham Eshtehardi, Tina Varghese, Abhinav Goyal, Puja K Mehta, William Kang, Jonathon Leipsic, Bríain Ó Hartaigh, C Noel Bairey Merz, Daniel S Berman, Heidi Gransar, Matthew J Budoff, Stephan Achenbach, Tracy Q Callister, Hugo Marques, Ronen Rubinshtein, Mouaz H Al-Mallah, Daniele Andreini, Gianluca Pontone, Filippo Cademartiri, Erica Maffei, Kavitha Chinnaiyan, Gilbert Raff, Martin Hadamitzky, Joerg Hausleiter, Gudrun Feuchtner, Philipp A Kaufmann, Todd C Villines, Benjamin J W Chow, James K Min, Leslee J Shaw
BACKGROUND: Patients with obstructive (≥50% stenosis) left main (LM) coronary artery disease (CAD) are at high risk for adverse events; prior studies have also documented worse outcomes among women than men with severe multivessel/LM CAD. However, the prognostic significance of nonobstructive (1%-49% stenosis) LM CAD, including sex-specific differences, has not been previously examined. METHODS AND RESULTS: In the long-term CONFIRM (Coronary CT Angiography Evaluation For Clinical Outcomes: An International Multicenter) registry, patients underwent elective coronary computed tomographic angiography for suspected CAD and were followed for 5 years...
August 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28789844/impact-of-coronary-artery-disease-in-patients-undergoing-transfemoral-transcatheter-aortic-valve-implantation
#12
Jasmin Shamekhi, Anja Stundl, Marcel Weber, Fritz Mellert, Armin Welz, Eberhard Grube, Georg Nickenig, Nikos Werner, Jan-Malte Sinning
BACKGROUND: The impact of coronary artery disease (CAD) and revascularization on outcome in patients undergoing transcatheter aortic valve implantation (TAVI) has not been fully elucidated so far. OBJECTIVES: To assess whether the degree of CAD influences the prognosis of patients undergoing TAVI. METHODS: Before TAVI, all patients underwent revascularization of the proximal vessels or the left main stem if indicated (stenosis ≥70% or 50%, respectively)...
July 25, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28780181/white-matter-tract-alterations-in-parkinson-s-disease-patients-with-punding
#13
Elisa Canu, Federica Agosta, Vladana Markovic, Igor Petrovic, Iva Stankovic, Francesca Imperiale, Tanja Stojkovic, Massimiliano Copetti, Vladimir S Kostic, Massimo Filippi
OBJECTIVE: To assess brain white matter tract alterations in patients with Parkinson's disease and punding (PD-punding) compared with controls and PD cases without any impulsive-compulsive behaviour. METHODS: Forty-nine PD patients (21 PD-punding and 28 PD with no impulsive-compulsive behaviours) and 28 controls were consecutively recruited. Clinical, cognitive and psychopathological evaluations were performed. Diffusion tensor MRI metrics of the main white matter tracts were assessed using a tractography approach...
July 27, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28779988/impact-of-polymorphism-rs7041-and-rs4588-of-vitamin-d-binding-protein-on-the-extent-of-coronary-artery-disease
#14
V Daffara, M Verdoia, R Rolla, M Nardin, P Marino, G Bellomo, A Carriero, G De Luca
BACKGROUND AND AIM: 25-hydroxyvitamin D deficiency represents a widespread social problem but also an emerging risk factor for cardiovascular disease. Genetic variants of the Vitamin D Binding Protein (VDBP), the main transporter of vitamin D in the bloodstream, have been shown to account for a significant variability in the levels and systemic effects of vitamin D. We investigated whether the single nucleotide polymorphisms, rs7041 and rs4588, of VDBP are associated to the prevalence and extent of coronary artery disease...
June 24, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28777391/design-and-numerical-evaluation-of-an-axial-partial-assist-blood-pump-for-chinese-and-other-heart-failure-patients
#15
Guang-Mao Liu, Dong-Hai Jin, Jian-Ye Zhou, Xi-Hang Jiang, Han-Song Sun, Yan Zhang, Hai-Bo Chen, Sheng-Shou Hu, Xing-Min Gui
A fully implantable axial left ventricular assist device LAP31 was developed for Chinese or other heart failure patients who need partial support. Based on the 5-Lpm total cardiac blood output of Chinese without heart failure disease, the design point of LAP31 was set to a flow rate of 3 Lpm with 100-mmHg pressure head. To achieve the required pressure head and good hemolytic performance, a structure that includes a spindly rotor hub and a diffuser with splitter and cantilevered main blades was developed. Computational fluid dynamics (CFD) was used to analyze the hydraulic and hemodynamic performance of LAP31...
August 2, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28776539/characteristics-management-and-outcomes-of-acute-heart-failure-in-the-emergency-department-a-multicenter-registry-study-with-1-year-follow-up-in-a-chinese-cohort-in-beijing
#16
Guo-Gan Wang, Si-Jia Wang, Jian Qin, Chun-Sheng Li, Xue-Zhong Yu, Hong Shen, Li-Pei Yang, Yan Fu, Ya-An Zheng, Bin Zhao, Dong-Min Yu, Fu-Jun Qin, De-Gui Zhou, Ying Li, Fu-Jun Liu, Wei Li, Wei Zhao, Xin Gao, Zheng Wang, Ming Jin, Hong Zeng, Yi Li, Guo-Xing Wang, Hong Zhou, Xiao-Lu Sun, Peng-Bo Wang, Kam-Sang Woo
BACKGROUND: The emergency department (ED) has a pivotal influence on the management of acute heart failure (AHF), but data concerning current ED management are scarce. This Beijing AHF Registry Study investigated the characteristics, ED management, and short- and long-term clinical outcomes of AHF. METHODS: This prospective, multicenter, observational study consecutively enrolled 3335 AHF patients who visited 14 EDs in Beijing from January 1, 2011, to September 23, 2012...
August 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28776266/impact-of-left-main-coronary-artery-disease-on-long-term-mortality-in-patients-undergoing-drug-eluting-stent-implantation
#17
Se Hun Kang, Cheol Whan Lee, Seunghee Baek, Pil Hyung Lee, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Seung-Jung Park
BACKGROUND: Limited data are available on long-term mortality according to the extent of coronary artery disease (CAD) in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES). We assessed long-term mortality DES implantation according to the extent of CAD and the impact of left main CAD alone on mortality among patients undergoing PCI with DES. METHODS AND RESULTS: A total of 18,716 patients were pooled from real-world PCI registries...
August 3, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28776069/porcine-arteriogenesis-based-on-vasa-vasorum-in-a-novel-semi-acute-occlusion-model-using-high-resolution-imaging
#18
Jonathan M Harnoss, Florian Krackhardt, Zully Ritter, Susanne Granzow, Dieter Felsenberg, Konrad Neumann, Lilach O Lerman, Fabian Riediger, Philipp Hillmeister, Peter Bramlage, Ivo R Buschmann
Bridging collaterals (BC) develop in several chronic total artery occlusion diseases, and can prevent extensive myocardial necrosis. Yet, their origin, growth process, and histo-morphology are still unclear. Since vasa vasorum (VV) may take part in collateralization, we hypothesized that VV are the basis for BCs. To comprehensively investigate this arteriogenesis process, we used high-resolution imaging, including corrosion casts, post-mortem angiography with stereoscopy, micro-CT, and immunohistology, in combination with a novel semi-acute vessel occlusion model...
August 3, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28772051/protocol-update-and-preliminary-results-of-eacvi-hfa-cardiac-oncology-toxicity-cot-registry-of-the-european-society-of-cardiology
#19
Patrizio Lancellotti, Maurizio Galderisi, Erwan Donal, Thor Edvardsen, Bogdan A Popescu, Dimitrios Farmakis, Gerasimos Filippatos, Gilbert Habib, Chiara Lestuzzi, Ciro Santoro, Marie Moonen, Guy Jerusalem, Maryna Andarala, Stefan D Anker
AIMS: European Association of Cardiovascular Imaging/Heart Failure Association Cardiac Oncology Toxicity Registry was launched in October 2014 as a European Society of Cardiology multicentre registry of breast cancer patients referred to imaging laboratories for routine surveillance, suspected, or confirmed anticancer drug-related cardiotoxicity (ADRC). After a pilot phase (1 year recruitment and 1 year follow-up), some changes have been made to the protocol (version 1.0) and electronic case report form...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28772045/translational-registry-for-cardiomyopathies-torch-rationale-and-first-results
#20
Claudia Seyler, Benjamin Meder, Tanja Weis, Thea Schwaneberg, Kerstin Weitmann, Wolfgang Hoffmann, Hugo A Katus, Andreas Dösch
AIMS: Non-ischemic cardiomyopathies (CMPs) comprise heart muscle disorders of different causes with high variability in disease phenotypes and clinical progression. The lack of national structures for the efficient recruitment, clinical and molecular classification, and follow-up of patients with non-ischemic CMPs limit the thorough analysis of disease mechanisms and the evaluation of novel diagnostic and therapeutic strategies. This paper describes a national, prospective, multicenter registry for patients with non-ischemic CMPs...
August 2017: ESC Heart Failure
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