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https://www.readbyqxmd.com/read/27145381/determination-of-albumin-adducts-of-4-4-methylenediphenyl-diisocyanate-in-workers-of-a-4-4-methylenedianiline-factory
#1
Gabriele Sabbioni, Nagaraju Dongari, Ovnair Sepai, Anoop Kumar
Lung sensitization and asthma are the main health effects of 4,4'-methylenediphenyl diisocyanate (MDI). Albumin adducts (isocyanate specific adducts) of MDI might be involved in the etiology of sensitization reactions. Albumin adducts of MDI have been found in subjects classified as 4,4'-methylenedianiline (MDA) workers. The mean adduct levels in these MDA-workers were 1.5 times higher than in MDI-workers of the same company. MDA-specific hemoglobin adducts, were present ten times more in the MDA-workers than in the MDI-workers...
May 4, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27121198/biomarkers-of-exposure-effect-and-susceptibility-in-workers-exposed-to-chloronitrobenzenes
#2
Gabriele Sabbioni, Hannu Norppa, Ari Hirvonen, Hilkka Järventaus, Christopher R Jones, Huifang Yan, Ovnair Sepai
Biomonitoring methods were applied to workers exposed to high levels of chloronitrobenzenes. The external dose, internal dose, biologically effective dose, and biological effects were determined. Individual susceptibility was assessed by analyzing genetic polymorphisms of glutathione S-transferases M1, P1 and T1, and N-acetyltransferases 1 and 2. When the markers of exposure and susceptibility were compared with the frequency of chromosomal aberrations, clinical blood and urine parameters, and health effects typical of chloronitrobenzenes exposure, only a few of the comparisons were statistically significant...
April 27, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27072255/relevance-of-risk-factors-of-breast-cancer-in-women-an-eastern-indian-scenario
#3
Ranen Kanti Aich, Nirmal Kumar Mondal, Bappaditya Chhatui, Harris Mahammad Sepai, Rajarshi Aich, Amitava Acharyya, Kaji Manir, Jibak Bhattacharaya
AIMS AND OBJECTIVE: Incidence of breast cancer is on the rise in developed as well as in developing countries. In India it has superseded cervical cancer as the commonest malignancy in women in urban areas. A lot of risk factors have been proposed from time to time that play a causative role in the natural course of this disease. However, they are based on data accumulated from studies conducted mostly in developed countries. Aim of this study was to find out whether these known and/or presumptive breast cancer risk factors hold true for women of developing countries like India also...
January 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/26036586/pilot-study-testing-a-european-human-biomonitoring-framework-for-biomarkers-of-chemical-exposure-in-children-and-their-mothers-experiences-in-the-uk
#4
Karen Exley, Dominique Aerts, Pierre Biot, Ludwine Casteleyn, Marike Kolossa-Gehring, Gerda Schwedler, Argelia Castaño, Jürgen Angerer, Holger M Koch, Marta Esteban, Birgit K Schindler, Greet Schoeters, Elly Den Hond, Milena Horvat, Louis Bloemen, Lisbeth E Knudsen, Reinhard Joas, Anke Joas, Ovnair Sepai
Exposure to a number of environmental chemicals in UK mothers and children has been assessed as part of the European biomonitoring pilot study, Demonstration of a Study to Coordinate and Perform Human Biomonitoring on a European Scale (DEMOCOPHES). For the European-funded project, 17 countries tested the biomonitoring guidelines and protocols developed by COPHES. The results from the pilot study in the UK are presented; 21 school children aged 6-11 years old and their mothers provided hair samples to measure mercury and urine samples, to measure cadmium, cotinine and several phthalate metabolites: mono(2-ethyl-5-hydroxyhexyl)phthalate (5OH-MEHP), mono(2-ethyl-5-oxo-hexyl)phthalate (5oxo-MEHP) and mono(2-ethylhexyl)phthalate (MEHP), mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-benzyl phthalate (MBzP) and mono-n-butyl phthalate (MnBP)...
October 2015: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/25746298/a-pilot-study-on-the-feasibility-of-european-harmonized-human-biomonitoring-strategies-towards-a-common-approach-challenges-and-opportunities
#5
L Casteleyn, B Dumez, K Becker, M Kolossa-Gehring, E Den Hond, G Schoeters, A Castaño, H M Koch, J Angerer, M Esteban, K Exley, O Sepai, L Bloemen, M Horvat, L E Knudsen, A Joas, R Joas, P Biot, G Koppen, M-C Dewolf, A Katsonouri, A Hadjipanayis, M Cerná, A Krsková, G Schwedler, U Fiddicke, J K S Nielsen, J F Jensen, P Rudnai, S Közepésy, M Mulcahy, R Mannion, A C Gutleb, M E Fischer, D Ligocka, M Jakubowski, M F Reis, S Namorado, I-R Lupsa, A E Gurzau, K Halzlova, M Jajcaj, D Mazej, J Tratnik Snoj, M Posada, E López, M Berglund, K Larsson, A Lehmann, P Crettaz, D Aerts
In 2004 the European Commission and Member States initiated activities towards a harmonized approach for Human Biomonitoring surveys throughout Europe. The main objective was to sustain environmental health policy by building a coherent and sustainable framework and by increasing the comparability of data across countries. A pilot study to test common guidelines for setting up surveys was considered a key step in this process. Through a bottom-up approach that included all stakeholders, a joint study protocol was elaborated...
August 2015: Environmental Research
https://www.readbyqxmd.com/read/25667172/fish-consumption-patterns-and-hair-mercury-levels-in-children-and-their-mothers-in-17-eu-countries
#6
Argelia Castaño, Francisco Cutanda, Marta Esteban, Peter Pärt, Carmen Navarro, Silvia Gómez, Montserrat Rosado, Ana López, Estrella López, Karen Exley, Birgit K Schindler, Eva Govarts, Ludwine Casteleyn, Marike Kolossa-Gehring, Ulrike Fiddicke, Holger Koch, Jürgen Angerer, Elly Den Hond, Greet Schoeters, Ovnair Sepai, Milena Horvat, Lisbeth E Knudsen, Dominique Aerts, Anke Joas, Pierre Biot, Reinhard Joas, José A Jiménez-Guerrero, Gema Diaz, Catherine Pirard, Andromachi Katsonouri, Milena Cerna, Arno C Gutleb, Danuta Ligocka, Fátima M Reis, Marika Berglund, Ioana-Rodica Lupsa, Katarína Halzlová, Corinne Charlier, Elizabeth Cullen, Adamos Hadjipanayis, Andrea Krsková, Janne F Jensen, Jeanette K Nielsen, Gerda Schwedler, Michael Wilhelm, Peter Rudnai, Szilvia Középesy, Fred Davidson, Mark E Fischer, Beata Janasik, Sónia Namorado, Anca E Gurzau, Michal Jajcaj, Darja Mazej, Janja Snoj Tratnik, Kristin Larsson, Andrea Lehmann, Pierre Crettaz, Giagkos Lavranos, Manuel Posada
The toxicity of methylmercury (MeHg) in humans is well established and the main source of exposure is via the consumption of large marine fish and mammals. Of particular concern are the potential neurodevelopmental effects of early life exposure to low-levels of MeHg. Therefore, it is important that pregnant women, children and women of childbearing age are, as far as possible, protected from MeHg exposure. Within the European project DEMOCOPHES, we have analyzed mercury (Hg) in hair in 1799 mother-child pairs from 17 European countries using a strictly harmonized protocol for mercury analysis...
August 2015: Environmental Research
https://www.readbyqxmd.com/read/25529752/gender-differences-in-cadmium-and-cotinine-levels-in-prepubertal-children
#7
A Fucic, D Plavec, L Casteleyn, D Aerts, P Biot, A Katsonouri, M Cerna, L E Knudsen, A Castano, P Rudnai, A Gutleb, D Ligocka, I-R Lupsa, M Berglund, M Horvat, K Halzlova, G Schoeters, G Koppen, A Hadjipanayis, A Krskova, S Középesy, M Arendt, M E Fischer, B Janasik, A E Gurzau, E S Gurzau, M Grandér, K Larsson, M Jajcaj, M Kolossa-Gehring, O Sepai, K Exley, M Bartolome, F Cutanda, D Mazej, J K S Nielsen, J Snoj-Tratnik, G Schwedler, U Fiddicke, M Seiwert, E Govarts, E Den Hond, H M Koch, A Lopez, A Joas, R Joas
Susceptibility to environmental stressors has been described for fetal and early childhood development. However, the possible susceptibility of the prepubertal period, characterized by the orchestration of the organism towards sexual maturation and adulthood has been poorly investigated and exposure data are scarce. In the current study levels of cadmium (Cd), cotinine and creatinine in urine were analyzed in a subsample 216 children from 12 European countries within the DEMOCOPHES project. The children were divided into six age-sex groups: boys (6-8 years, 9-10 years and 11 years old), and girls (6-7 years, 8-9 years, 10-11 years)...
August 2015: Environmental Research
https://www.readbyqxmd.com/read/25526891/policy-recommendations-and-cost-implications-for-a-more-sustainable-framework-for-european-human-biomonitoring-surveys
#8
Anke Joas, Lisbeth E Knudsen, Marike Kolossa-Gehring, Ovnair Sepai, Ludwine Casteleyn, Greet Schoeters, Jürgen Angerer, Argelia Castaño, Dominique Aerts, Pierre Biot, Milena Horvat, Louis Bloemen, M Fátima Reis, Ioana-Rodica Lupsa, Andromachi Katsonouri, Milena Cerna, Marika Berglund, Pierre Crettaz, Peter Rudnai, Katarina Halzlova, Maurice Mulcahy, Arno C Gutleb, Marc E Fischer, Georg Becher, Nadine Fréry, Genon Jensen, Lisette Van Vliet, Holger M Koch, Elly Den Hond, Ulrike Fiddicke, Marta Esteban, Karen Exley, Gerda Schwedler, Margarete Seiwert, Danuta Ligocka, Philipp Hohenblum, Soterios Kyrtopoulos, Maria Botsivali, Elena DeFelip, Claude Guillou, Fabiano Reniero, Regina Grazuleviciene, Toomas Veidebaum, Thit A Mørck, Jeanette K S Nielsen, Janne F Jensen, Teresa C Rivas, Jinny Sanchez, Gudrun Koppen, Roel Smolders, Szilvia Kozepesy, Adamos Hadjipanayis, Andrea Krskova, Rory Mannion, Marek Jakubowski, J Aleksandra Fucic, Jose Pereira-Miguel, Anca E Gurzau, Michal Jajcaj, Darja Mazej, Janja Snoj Tratnik, Andrea Lehmann, Kristin Larsson, Birgit Dumez, Reinhard Joas
The potential of Human Biomonitoring (HBM) in exposure characterisation and risk assessment is well established in the scientific HBM community and regulatory arena by many publications. The European Environment and Health Strategy as well as the Environment and Health Action Plan 2004-2010 of the European Commission recognised the value of HBM and the relevance and importance of coordination of HBM programmes in Europe. Based on existing and planned HBM projects and programmes of work and capabilities in Europe the Seventh Framework Programme (FP 7) funded COPHES (COnsortium to Perform Human Biomonitoring on a European Scale) to advance and improve comparability of HBM data across Europe...
August 2015: Environmental Research
https://www.readbyqxmd.com/read/25499539/communication-in-a-human-biomonitoring-study-focus-group-work-public-engagement-and-lessons-learnt-in-17-european-countries
#9
Karen Exley, Noemi Cano, Dominique Aerts, Pierre Biot, Ludwine Casteleyn, Marike Kolossa-Gehring, Gerda Schwedler, Argelia Castaño, Jürgen Angerer, Holger M Koch, Marta Esteban, Greet Schoeters, Elly Den Hond, Milena Horvat, Louis Bloemen, Lisbeth E Knudsen, Reinhard Joas, Anke Joas, Marie-Christine Dewolf, Els Van de Mieroop, Andromachi Katsonouri, Adamos Hadjipanayis, Milena Cerna, Andrea Krskova, Kerstin Becker, Ulrike Fiddicke, Margarete Seiwert, Thit A Mørck, Peter Rudnai, Szilvia Kozepesy, Elizabeth Cullen, Anne Kellegher, Arno C Gutleb, Marc E Fischer, Danuta Ligocka, Joanna Kamińska, Sónia Namorado, M Fátima Reis, Ioana-Rodica Lupsa, Anca E Gurzau, Katarina Halzlova, Michal Jajcaj, Darja Mazej, Janja Snoj Tratnik, Olga Huetos, Ana López, Marika Berglund, Kristin Larsson, Ovnair Sepai
A communication strategy was developed by The Consortium to Perform Human Biomonitoring on a European Scale (COPHES), as part of its objectives to develop a framework and protocols to enable the collection of comparable human biomonitoring data throughout Europe. The framework and protocols were tested in the pilot study DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human biomonitoring on a European Scale). The aims of the communication strategy were to raise awareness of human biomonitoring, encourage participation in the study and to communicate the study results and their public health significance...
August 2015: Environmental Research
https://www.readbyqxmd.com/read/25493439/first-steps-toward-harmonized-human-biomonitoring-in-europe-demonstration-project-to-perform-human-biomonitoring-on-a-european-scale
#10
Elly Den Hond, Eva Govarts, Hanny Willems, Roel Smolders, Ludwine Casteleyn, Marike Kolossa-Gehring, Gerda Schwedler, Margarete Seiwert, Ulrike Fiddicke, Argelia Castaño, Marta Esteban, Jürgen Angerer, Holger M Koch, Birgit K Schindler, Ovnair Sepai, Karen Exley, Louis Bloemen, Milena Horvat, Lisbeth E Knudsen, Anke Joas, Reinhard Joas, Pierre Biot, Dominique Aerts, Gudrun Koppen, Andromachi Katsonouri, Adamos Hadjipanayis, Andrea Krskova, Marek Maly, Thit A Mørck, Peter Rudnai, Szilvia Kozepesy, Maurice Mulcahy, Rory Mannion, Arno C Gutleb, Marc E Fischer, Danuta Ligocka, Marek Jakubowski, M Fátima Reis, Sónia Namorado, Anca Elena Gurzau, Ioana-Rodica Lupsa, Katarina Halzlova, Michal Jajcaj, Darja Mazej, Janja Snoj Tratnik, Ana López, Estrella Lopez, Marika Berglund, Kristin Larsson, Andrea Lehmann, Pierre Crettaz, Greet Schoeters
BACKGROUND: For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health. OBJECTIVES: We developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe. METHODS: In 17 European countries, we measured mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of 1,844 children (5-11 years of age) and their mothers...
March 2015: Environmental Health Perspectives
https://www.readbyqxmd.com/read/25483984/mercury-analysis-in-hair-comparability-and-quality-assessment-within-the-transnational-cophes-democophes-project
#11
Marta Esteban, Birgit Karin Schindler, José Antonio Jiménez, Holger Martin Koch, Jürgen Angerer, Montserrat Rosado, Silvia Gómez, Ludwine Casteleyn, Marike Kolossa-Gehring, Kerstin Becker, Louis Bloemen, Greet Schoeters, Elly Den Hond, Ovnair Sepai, Karen Exley, Milena Horvat, Lisbeth E Knudsen, Anke Joas, Reinhard Joas, Dominique Aerts, Pierre Biot, Daniela Borošová, Fred Davidson, Irina Dumitrascu, Marc E Fischer, Margaretha Grander, Beata Janasik, Kate Jones, Lucie Kašparová, Thorjørn Larssen, Miklos Naray, Flemming Nielsen, Philipp Hohenblum, Rui Pinto, Catherine Pirard, Gregory Plateel, Janja Snoj Tratnik, Jürgen Wittsiepe, Argelia Castaño
Human biomonitoring (HBM) is an effective tool for assessing actual exposure to chemicals that takes into account all routes of intake. Although hair analysis is considered to be an optimal biomarker for assessing mercury exposure, the lack of harmonization as regards sampling and analytical procedures has often limited the comparison of data at national and international level. The European-funded projects COPHES and DEMOCOPHES developed and tested a harmonized European approach to Human Biomonitoring in response to the European Environment and Health Action Plan...
August 2015: Environmental Research
https://www.readbyqxmd.com/read/25465922/exposure-determinants-of-cadmium-in-european-mothers-and-their-children
#12
Marika Berglund, Kristin Larsson, Margaretha Grandér, Ludwine Casteleyn, Marike Kolossa-Gehring, Gerda Schwedler, Argelia Castaño, Marta Esteban, Jürgen Angerer, Holger M Koch, Birgit K Schindler, Greet Schoeters, Roel Smolders, Karen Exley, Ovnair Sepai, Luies Blumen, Milena Horvat, Lisbeth E Knudsen, Thit A Mørck, Anke Joas, Reinhard Joas, Pierre Biot, Dominique Aerts, Koen De Cremer, Ilse Van Overmeire, Andromachi Katsonouri, Adamos Hadjipanayis, Milena Cerna, Andrea Krskova, Jeanette K S Nielsen, Janne Fangel Jensen, Peter Rudnai, Szilvia Kozepesy, Chris Griffin, Ian Nesbitt, Arno C Gutleb, Marc E Fischer, Danuta Ligocka, Marek Jakubowski, M Fátima Reis, Sónia Namorado, Ioana-Rodica Lupsa, Anca E Gurzau, Katarina Halzlova, Michal Jajcaj, Darja Mazej, Janja Snoj Tratnik, Ana Lopez, Ana Cañas, Andrea Lehmann, Pierre Crettaz, Elly Den Hond, Eva Govarts
The metal cadmium (Cd) is a widespread environmental pollutant with documented adverse effects on the kidneys and bones from long-term environmental exposure, but with insufficiently elucidated public health consequences such as risk of cardiovascular disease, hormone-related cancer in adults and developmental effects in children. This study is the first pan-European human biomonitoring project that succeeded in performing harmonized measurements of Cd in urine in a comparable way in mother-child couples from 16 European countries...
August 2015: Environmental Research
https://www.readbyqxmd.com/read/25454101/lessons-learnt-on-recruitment-and-fieldwork-from-a-pilot-european-human-biomonitoring-survey
#13
Ulrike Fiddicke, Kerstin Becker, Gerda Schwedler, Margarete Seiwert, Reinhard Joas, Anke Joas, Pierre Biot, Dominique Aerts, Ludwine Casteleyn, Birgit Dumez, Argelia Castaño, Marta Esteban, Jürgen Angerer, Holger M Koch, Greet Schoeters, Elly Den Hond, Ovnair Sepai, Karen Exley, Lisbeth E Knudsen, Milena Horvat, Louis Bloemen, Andromachi Katsonouri, Adamos Hadjipanayis, Milena Cerna, Andrea Krsková, Janne Fangel Jensen, Jeanette K S Nielsen, Peter Rudnai, Szilvia Közepésy, Arno C Gutleb, Marc E Fischer, Danuta Ligocka, Joanna Kamińska, M Fátima Reis, Sónia Namorado, Ioana-Rodica Lupsa, Anca E Gurzau, Katarína Halzlová, Darja Mazej, Janja Snoj Tratnik, Teresa C Rivas, Silvia Gómez, Marika Berglund, Kristin Larsson, Andrea Lehmann, Pierre Crettaz, Marie-Christine Dewolf, Damien Burns, Anne Kellegher, Marike Kolossa-Gehring
Within the European Environment and Health Action Plan an initiative to establish a coherent human biomonitoring approach in Europe was started. The project COPHES (COnsortium to Perform Human biomonitoring on a European Scale ) developed recommendations for a harmonized conduct of a human biomonitoring (HBM) survey which came into action as the pilot study DEMOCOPHES (DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale). Seventeen European countries conducted a survey with harmonized instruments for, inter alia, recruitment, fieldwork and sampling, in autumn/winter 2011/2012...
August 2015: Environmental Research
https://www.readbyqxmd.com/read/25440295/urinary-bpa-measurements-in-children-and-mothers-from-six-european-member-states-overall-results-and-determinants-of-exposure
#14
Adrian Covaci, Elly Den Hond, Tinne Geens, Eva Govarts, Gudrun Koppen, Hanne Frederiksen, Lisbeth E Knudsen, Thit A Mørck, Arno C Gutleb, Cedric Guignard, Emanuelle Cocco, Milena Horvat, Ester Heath, Tina Kosjek, Darja Mazej, Janja Snoj Tratnik, Argelia Castaño, Marta Esteban, Francisco Cutanda, Juan José Ramos, Marika Berglund, Kristin Larsson, Bo A G Jönsson, Pierre Biot, Ludwine Casteleyn, Reinhard Joas, Anke Joas, Louis Bloemen, Ovnair Sepai, Karen Exley, Greet Schoeters, Jürgen Angerer, Marike Kolossa-Gehring, Ulrike Fiddicke, Dominique Aerts, Holger M Koch
For the first time in Europe, both European-wide and country-specific levels of urinary Bisphenol A (BPA) were obtained through a harmonized protocol for participant recruitment, sampling and quality controlled biomarker analysis in the frame of the twin projects COPHES and DEMOCOPHES. 674 child-mother pairs were recruited through schools or population registers from six European member states (Belgium, Denmark, Luxembourg, Slovenia, Spain and Sweden). Children (5-12 y) and mothers donated a urine sample. Information on socio-demographic characteristics, life style, dietary habits, and educational level of the parents was provided by mothers...
August 2015: Environmental Research
https://www.readbyqxmd.com/read/25440294/interpreting-biomarker-data-from-the-cophes-democophes-twin-projects-using-external-exposure-data-to-understand-biomarker-differences-among-countries
#15
R Smolders, E Den Hond, G Koppen, E Govarts, H Willems, L Casteleyn, M Kolossa-Gehring, U Fiddicke, A Castaño, H M Koch, J Angerer, M Esteban, O Sepai, K Exley, L Bloemen, M Horvat, L E Knudsen, A Joas, R Joas, P Biot, D Aerts, A Katsonouri, A Hadjipanayis, M Cerna, A Krskova, G Schwedler, M Seiwert, J K S Nielsen, P Rudnai, S Közepesy, D S Evans, M P Ryan, A C Gutleb, M E Fischer, D Ligocka, M Jakubowski, M F Reis, S Namorado, I-R Lupsa, A E Gurzau, K Halzlova, E Fabianova, D Mazej, J Tratnik Snoj, S Gomez, S González, M Berglund, K Larsson, A Lehmann, P Crettaz, G Schoeters
In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed the first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother-child pairs, individual lifestyle data were collected and cadmium, cotinine and certain phthalate metabolites were measured in urine. Total mercury was determined in hair samples. While the main goal of the COPHES/DEMOCOPHES twin projects was to develop and test harmonized protocols and procedures, the goal of the current paper is to investigate whether the observed differences in biomarker values among the countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality and lifestyle...
August 2015: Environmental Research
https://www.readbyqxmd.com/read/25440293/the-danish-contribution-to-the-european-democophes-project-a-description-of-cadmium-cotinine-and-mercury-levels-in-danish-mother-child-pairs-and-the-perspectives-of-supplementary-sampling-and-measurements
#16
Thit A Mørck, Flemming Nielsen, Jeanette K S Nielsen, Janne F Jensen, Pernille W Hansen, Anne K Hansen, Lea N Christoffersen, Volkert D Siersma, Ida H Larsen, Linette K Hohlmann, Mette T Skaanild, Hanne Frederiksen, Pierre Biot, Ludwine Casteleyn, Marike Kolossa-Gehring, Gerda Schwedler, Argelia Castaño, Jürgen Angerer, Holger M Koch, Marta Esteban, Greet Schoeters, Elly Den Hond, Karen Exley, Ovnair Sepai, Louis Bloemen, Reinhard Joas, Anke Joas, Ulrike Fiddicke, Ana Lopez, Ana Cañas, Dominique Aerts, Lisbeth E Knudsen
Human biomonitoring (HBM) is an important tool, increasingly used for measuring true levels of the body burdens of environmental chemicals in the general population. In Europe, a harmonized HBM program was needed to open the possibility to compare levels across borders. To explore the prospect of a harmonized European HBM project, DEMOCOPHES (DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale) was completed in 17 European countries. The basic measurements performed in all implemented countries of DEMOCOPHES included cadmium, cotinine and phthalate metabolites in urine and mercury in hair...
August 2015: Environmental Research
https://www.readbyqxmd.com/read/25233018/mercury-exposure-in-ireland-results-of-the-democophes-human-biomonitoring-study
#17
Elizabeth Cullen, David S Evans, Fred Davidson, Padraig Burke, Damien Burns, Andrew Flanagan, Chris Griffin, Anne Kellegher, Rory Mannion, Maurice Mulcahy, Michael Ryan, Pierre Biot, Ludwine Casteleyn, Argelia Castaño, Jürgen Angerer, Holger M Koch, Marta Esteban, Birgit K Schindler, Carmen Navarro, Marike Kolossa-Gehring, Ulrike Fiddicke, Greet Schoeters, Elly Den Hond, Ovnair Sepai, Karen Exley, Louis Bloemen, Lisbeth E Knudsen, Reinhard Joas, Anke Joas, Dominique Aerts
BACKGROUND: Monitoring of human exposure to mercury is important due to its adverse health effects. This study aimed to determine the extent of mercury exposure among mothers and their children in Ireland, and to identify factors associated with elevated levels. It formed part of the Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale (DEMOCOPHES) pilot biomonitoring study. METHODS: Hair mercury concentrations were determined from a convenience sample of 120 mother/child pairs...
September 2014: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/24452505/impact-of-long-term-exposure-to-sodium-arsenite-on-cytogenetic-radiation-damage
#18
Otilia Nuta, Jayne Moquet, Simon Bouffler, David Lloyd, Ovnair Sepai, Kai Rothkamm
The aim of this work was to investigate the impact of long-term exposure to low concentrations of sodium arsenite on the cellular response to ionising radiation. Human lymphoblastoid GM1899a cells were cultured in the presence of sodium arsenite for up to six months. Following chemical exposure, acute challenge doses of X-rays were given and chromosome damage (dicentrics, acentric fragments, translocations, micronuclei) as well as cell growth and changes in cell cycle kinetics were determined. Initial short-term chemical exposures determined 8 ng/ml (60 nM) sodium arsenite as a suitable concentration for chronic exposures, which is below the current World Health Organization limit for arsenic in drinking water...
March 2014: Mutagenesis
https://www.readbyqxmd.com/read/24405937/the-european-cophes-democophes-project-towards-transnational-comparability-and-reliability-of-human-biomonitoring-results
#19
Birgit Karin Schindler, Marta Esteban, Holger Martin Koch, Argelia Castano, Stephan Koslitz, Ana Cañas, Ludwine Casteleyn, Marike Kolossa-Gehring, Gerda Schwedler, Greet Schoeters, Elly Den Hond, Ovnair Sepai, Karen Exley, Louis Bloemen, Milena Horvat, Lisbeth E Knudsen, Anke Joas, Reinhard Joas, Pierre Biot, Dominique Aerts, Ana Lopez, Olga Huetos, Andromachi Katsonouri, Katja Maurer-Chronakis, Lucie Kasparova, Karel Vrbík, Peter Rudnai, Miklos Naray, Cedric Guignard, Marc E Fischer, Danuta Ligocka, Beata Janasik, M Fátima Reis, Sónia Namorado, Cristian Pop, Irina Dumitrascu, Katarina Halzlova, Eleonora Fabianova, Darja Mazej, Janja Snoj Tratnik, Marika Berglund, Bo Jönsson, Andrea Lehmann, Pierre Crettaz, Hanne Frederiksen, Flemming Nielsen, Helena McGrath, Ian Nesbitt, Koen De Cremer, Guido Vanermen, Gudrun Koppen, Michael Wilhelm, Kerstin Becker, Jürgen Angerer
COPHES/DEMOCOPHES has its origins in the European Environment and Health Action Plan of 2004 to "develop a coherent approach on human biomonitoring (HBM) in Europe". Within this twin-project it was targeted to collect specimens from 120 mother-child-pairs in each of the 17 participating European countries. These specimens were investigated for six biomarkers (mercury in hair; creatinine, cotinine, cadmium, phthalate metabolites and bisphenol A in urine). The results for mercury in hair are described in a separate paper...
July 2014: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/24333995/hair-mercury-and-urinary-cadmium-levels-in-belgian-children-and-their-mothers-within-the-framework-of-the-cophes-democophes-projects
#20
Catherine Pirard, Gudrun Koppen, Koen De Cremer, Ilse Van Overmeire, Eva Govarts, Marie-Christine Dewolf, Els Van De Mieroop, Dominique Aerts, Pierre Biot, Ludwine Casteleyn, Marike Kolossa-Gehring, Gerda Schwedler, Jürgen Angerer, Holger M Koch, Birgit K Schindler, Argelia Castaño, Marta Esteban, Greet Schoeters, Elly Den Hond, Ovnair Sepai, Karen Exley, Milena Horvat, Louis Bloemen, Lisbeth E Knudsen, Reinhard Joas, Anke Joas, Joris Van Loco, Corinne Charlier
A harmonized human biomonitoring pilot study was set up within the frame of the European projects DEMOCOPHES and COPHES. In 17 European countries, biomarkers of some environmental pollutants, including urinary cadmium and hair mercury, were measured in children and their mothers in order to obtain European-wide comparison values on these chemicals. The Belgian participant population consisted in 129 school children (6-11 years) and their mothers (≤ 45 years) living in urban or rural areas of Belgium. The geometric mean levels for mercury in hair were 0...
February 15, 2014: Science of the Total Environment
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