keyword
https://read.qxmd.com/read/38001476/development-and-evaluation-of-a-method-to-assess-breast-cancer-risk-using-a-longitudinal-history-of-mammographic-density-a-cohort-study
#21
JOURNAL ARTICLE
Emma C Atakpa, Diana S M Buist, Erin J Aiello Bowles, Jack Cuzick, Adam R Brentnall
BACKGROUND: Women with dense breasts have an increased risk of breast cancer. However, breast density is measured with variability, which may reduce the reliability and accuracy of its association with breast cancer risk. This is particularly relevant when visually assessing breast density due to variation in inter- and intra-reader assessments. To address this issue, we developed a longitudinal breast density measure which uses an individual woman's entire history of mammographic density, and we evaluated its association with breast cancer risk as well as its predictive ability...
November 24, 2023: Breast Cancer Research: BCR
https://read.qxmd.com/read/37987405/lipid-disturbances-in-breast-cancer-patients-during-chemotherapy
#22
JOURNAL ARTICLE
Aikaterini Alimperti, Victoria Alikari, Maria Tsironi, Andrea Paola Rojas Gil, Dimitrios Papageorgiou, Petros Kolovos, Aspasia Panagiotou, George I Panoutsopoulos, Maria Lavdaniti, Sofia Zyga
UNLABELLED: Breast cancer is the most common cancer in women. Cardiovascular diseases are common complications after chemotherapy due to the effect of the drug on lipid levels. This study aimed to explore the changes in lipid profiles in patients with breast cancer under chemotherapy. METHODS: In this prospective study, 50 patients with breast cancer participated. Three biochemical-lipid hematological tests were performed: total cholesterol (TC), triglycerides (TGs), High-Density Lipoprotein (HDL-C), and Low-Density Lipoprotein (LDL-C) before initiation (pre-chemotherapy), at the start (first follow-up), and at the completion (second follow-up) of the first cycle of chemotherapy...
October 25, 2023: Nursing Reports
https://read.qxmd.com/read/37976443/extending-the-breast-cancer-surveillance-consortium-model-of-invasive-breast-cancer
#23
JOURNAL ARTICLE
Charlotte C Gard, Jeffrey A Tice, Diana L Miglioretti, Brian L Sprague, Michael C S Bissell, Louise M Henderson, Karla Kerlikowske
PURPOSE: We extended the Breast Cancer Surveillance Consortium (BCSC) version 2 (v2) model of invasive breast cancer risk to include BMI, extended family history of breast cancer, and age at first live birth (version 3 [v3]) to better inform appropriate breast cancer prevention therapies and risk-based screening. METHODS: We used Cox proportional hazards regression to estimate the age- and race- and ethnicity-specific relative hazards for family history of breast cancer, breast density, history of benign breast biopsy, BMI, and age at first live birth for invasive breast cancer in the BCSC cohort...
November 17, 2023: Journal of Clinical Oncology
https://read.qxmd.com/read/37966690/fatigue-and-quality-of-life-during-neoadjuvant-chemotherapy-of-early-breast-cancer-a-prospective-multicenter-cohort-study
#24
JOURNAL ARTICLE
Florian Pelzer, Wilfried Tröger, Marcus Reif, Susanne Schönberg, David D Martin, Cornelia Müller, Isabell Utz-Billing, Thorsten Kühn, Stephan Baumgartner, Marion Kiechle, Daniela Paepke
BACKGROUND: Few measurements of fatigue and quality of life have been performed during neoadjuvant chemotherapy of early breast cancer. This study evaluates fatigue and quality of life experienced by early breast cancer patients during neoadjuvant chemotherapy and their association with different clinical parameters. METHODS: Fifty-four stage I-III patients' responses to the Multidimensional Fatigue Inventory (MFI) and to the Functional Assessment of Cancer Therapy-Breast (FACT-B) were analyzed by a linear covariance pattern model...
November 15, 2023: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/37933880/association-between-mammographic-breast-density-and-breast-carcinoma
#25
MULTICENTER STUDY
Dilini Nanayakkara, Chathurika Batuwitage, Pubudu Chulasiri, Dilupani Abeywardhana, Subhashini Samaraweera
INTRODUCTION: Breast cancer has a high incidence and is showing a rising trend in Sri Lanka. Mammographic breast density is a radiologically measurable risk factor which has been found to be significantly associated with breast cancer risk in women with minor variations between ethnicities. However, the Asian populations studied in previous international studies were of Japanese, Chinese and Filipino ethnicities and not Sri Lankan or other South Asian ethnicities. Also, a previous Sri Lankan study found no significant association between breast density and breast cancer...
November 30, 2022: Ceylon Medical Journal
https://read.qxmd.com/read/37933633/-a-quantitative-approach-to-assess-the-correlation-of-mammographic-breast-density-with-selected-affecting-factors
#26
JOURNAL ARTICLE
Lakmini Chandrasiri, Badra Hewavithana, Ayesh Jayasinghe, Weerakoon Bimali, Prabhath Gunathilake, Sachith Abeysundara
INTRODUCTION: Breast density plays a significant role in increasing an individual's risk of breast cancer and its mortality rate. OBJECTIVES: We aimed to assess the correlations of mammographic breast density with age, body mass index, weight, height and parity for the first time in Sri Lankan women. METHODS: 52 participants who underwent diagnostic mammographic examinations at a tertiary care hospital in Sri Lanka were selected for the study...
November 30, 2022: Ceylon Medical Journal
https://read.qxmd.com/read/37881237/factors-associated-with-longitudinal-changes-in-mammographic-density-in-a-multiethnic-breast-screening-cohort-of-postmenopausal-women
#27
JOURNAL ARTICLE
Hannah Lui Park, Argyrios Ziogas, Stephen A Feig, Roza Lorin Kirmizi, Christie Jiwon Lee, Andrea Alvarez, Rachel McFarland Lucia, Deborah Goodman, Kathryn M Larsen, Richard Kelly, Hoda Anton-Culver
BACKGROUND: Breast density is an important risk factor for breast cancer and is known to be associated with characteristics such as age, race, and hormone levels; however, it is unclear what factors contribute to changes in breast density in postmenopausal women over time. Understanding factors associated with density changes may enable a better understanding of breast cancer risk and facilitate potential strategies for prevention. METHODS: This study investigated potential associations between personal factors and changes in mammographic density in a cohort of 3,392 postmenopausal women with no personal history of breast cancer between 2011 and 2017...
2023: Breast Journal
https://read.qxmd.com/read/37816192/mammographic-breast-density-and-risk-of-ovarian-cancer-in-korean-women
#28
JOURNAL ARTICLE
Thi Xuan Mai Tran, Soyeoun Kim, Boyoung Park
BACKGROUND: This study aimed to investigate the potential association between mammographic breast density and ovarian cancer risk. METHODS: This retrospective cohort study included women ≥ 40 years of age who underwent a mammography screening from 2009 to 2014. Breast density was assessed using the Breast Imaging-Reporting and Data System (BI-RADS). The primary outcome was ovarian cancer development, and the cases were recorded until 2020. Cox proportional hazards regression was used to assess the association between breast density and ovarian cancer development...
October 10, 2023: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/37814330/lipidome-of-mammographic-breast-density-in-premenopausal-women
#29
JOURNAL ARTICLE
Kayla R Getz, Myung Sik Jeon, Chongliang Luo, Jingqin Luo, Adetunji T Toriola
BACKGROUND: High mammographic breast density (MBD) is a strong risk factor for breast cancer development, but the biological mechanisms underlying MBD are unclear. Lipids play important roles in cell differentiation, and perturbations in lipid metabolism are implicated in cancer development. Nevertheless, no study has applied untargeted lipidomics to profile the lipidome of MBD. Through this study, our goal is to characterize the lipidome of MBD in premenopausal women. METHODS: Premenopausal women were recruited during their annual screening mammogram at the Washington University School of Medicine in St...
October 9, 2023: Breast Cancer Research: BCR
https://read.qxmd.com/read/37814233/breast-cancer-risk-factors-and-mammographic-density-among-12518-average-risk-women-in-rural-china
#30
JOURNAL ARTICLE
Huijiao Yan, Wenhui Ren, Mengmeng Jia, Peng Xue, Zhifang Li, Shaokai Zhang, Lichun He, Youlin Qiao
BACKGROUND: Mammographic density (MD) is a strong risk factor for breast cancer. We aimed to evaluate the association between MD and breast cancer related risk factors among average-risk women in rural China. METHODS: This is a population-based screening study. 12518 women aged 45-64 years with complete MD data from three maternal and childcare hospitals in China were included in the final analysis. ORs and 95%CIs were estimated using generalized logit model by comparing each higher MD (BI-RADS b, c, d) to the lowest group (BI-RADS a)...
October 9, 2023: BMC Cancer
https://read.qxmd.com/read/37770952/predicting-mammographic-density-with-linear-ultrasound-transducers
#31
JOURNAL ARTICLE
Annika Behrens, Peter A Fasching, Eva Schwenke, Paul Gass, Lothar Häberle, Felix Heindl, Katharina Heusinger, Laura Lotz, Hannah Lubrich, Caroline Preuß, Michael O Schneider, Rüdiger Schulz-Wendtland, Florian M Stumpfe, Michael Uder, Marius Wunderle, Anna L Zahn, Carolin C Hack, Matthias W Beckmann, Julius Emons
BACKGROUND: High mammographic density (MD) is a risk factor for the development of breast cancer (BC). Changes in MD are influenced by multiple factors such as age, BMI, number of full-term pregnancies and lactating periods. To learn more about MD, it is important to establish non-radiation-based, alternative examination methods to mammography such as ultrasound assessments. METHODS: We analyzed data from 168 patients who underwent standard-of-care mammography and performed additional ultrasound assessment of the breast using a high-frequency (12 MHz) linear probe of the VOLUSON® 730 Expert system (GE Medical Systems Kretztechnik GmbH & Co OHG, Austria)...
September 28, 2023: European Journal of Medical Research
https://read.qxmd.com/read/37764684/lifestyle-factors-and-energy-intakes-with-risks-of-breast-cancer-among-pre-and-post-menopausal-women-in-taiwan
#32
JOURNAL ARTICLE
Meng-Chuan Huang, Tz-Ting Huang, Hsin-Chun Feng, I-Chun Chen, Chiao-I Chang, Tsu-Nai Wang, Wen-Hung Kuo, Ming-Yang Wang, Li-Wei Tsai, Szu-Yi Li, Chiun-Sheng Huang, Yen-Shen Lu, Ching-Hung Lin
Although the incidence of invasive breast cancer (BC) among women in Asian is generally lower than that in Western countries, the incidence of BC has been on the rise in the past three decades in Asian countries. This hospital-based case-control study aimed to explore the relationship between dietary and metabolic factors and BC risk in pre- and post-menopausal women. We enrolled 285 patients with newly diagnosed BC at the National Taiwan University Hospital and 297 controls from the local community and hospital staff...
September 7, 2023: Nutrients
https://read.qxmd.com/read/37760486/personalized-breast-cancer-screening-a-risk-prediction-model-based-on-women-attending-breastscreen-norway
#33
JOURNAL ARTICLE
Javier Louro, Marta Román, Nataliia Moshina, Camilla F Olstad, Marthe Larsen, Silje Sagstad, Xavier Castells, Solveig Hofvind
BACKGROUND: We aimed to develop and validate a model predicting breast cancer risk for women targeted by breast cancer screening. METHOD: This retrospective cohort study included 57,411 women screened at least once in BreastScreen Norway during the period from 2007 to 2019. The prediction model included information about age, mammographic density, family history of breast cancer, body mass index, age at menarche, alcohol consumption, exercise, pregnancy, hormone replacement therapy, and benign breast disease...
September 12, 2023: Cancers
https://read.qxmd.com/read/37729221/association-of-polycystic-ovary-syndrome-with-mammographic-density-in-turkish-women-a-population-based-case-control-study
#34
JOURNAL ARTICLE
Ayşe Rabia Şenkaya, Sabahattin Anıl Arı, İbrahim Karaca, Eyüp Kebapçı, Eren İsmailoğlu, Deniz Can Öztekin
OBJECTIVE: The objective of this study was to investigate the breast densities and Breast Imaging-Reporting and Data System scores of patients with polycystic ovary syndrome and normoovulatory women and to determine whether these patients constitute a high-risk population for breast cancer. METHODS: This retrospective case-control study was conducted at our institution between January 2022 and December 2022, involving patients diagnosed with polycystic ovary syndrome...
2023: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/37721459/infant-body-composition-a-comprehensive-overview-of-assessment-techniques-nutrition-factors-and-health-outcomes
#35
REVIEW
Maggie L Jerome, Vivian Valcarce, Laura Lach, Elena Itriago, Ariel A Salas
Body composition assessment is a valuable tool for clinical assessment and research that has implications for long-term health. Unlike traditional measurements such as anthropometrics or body mass index, body composition assessments provide more accurate measures of body fatness and lean mass. Moreover, depending on the technique, they can offer insight into regional body composition, bone mineral density, and brown adipose tissue. Various methods of body composition assessment exist, including air displacement plethysmography, dual-energy x-ray absorptiometry, bioelectrical impedance, magnetic resonance imaging, D3 creatine, ultrasound, and skinfold thickness, each with its own strengths and limitations...
October 2023: Nutrition in Clinical Practice
https://read.qxmd.com/read/37700300/exercise-interventions-on-body-composition-and-quality-of-life-of-overweight-obese-breast-cancer-survivors-a-meta-analysis
#36
JOURNAL ARTICLE
Hongchang Yang, Li Liu, Xiaoxia Zhang
BACKGROUND: This meta-analysis aimed to assess the effects of exercise interventions on body composition and quality of life in overweight/obese breast cancer survivors. METHODS: Eligible randomized controlled trials (RCTs) were searched from the Cochrane Library, PubMed, and Embase databases and assessed using the Cochrane Collaboration's assessing risk tool. The effect size was pooled as weighted mean difference (WMD) for body composition variables (i.e., body mass index [BMI], body fat, body weight, fat mass, lean mass, bone mineral density) and quality of life (i...
September 12, 2023: BMC Women's Health
https://read.qxmd.com/read/37673107/impact-of-muscle-measures-on-outcome-in-patients-receiving-endocrine-therapy-for-metastatic-breast-cancer-analysis-of-ecog-acrin-e2112
#37
RANDOMIZED CONTROLLED TRIAL
Tarah J Ballinger, Helga S Marques, Gloria Xue, Richard Hoffman, Constantine Gatsonis, Fengmin Zhao, Kathy D Miller, Joseph Sparano, Roisin M Connolly
BACKGROUND: Observational data investigating the relationship between body habitus and outcomes in breast cancer have been variable and inconsistent, largely centered in the curative setting and focused on weight-based metrics. This study evaluated the impact of muscle measures on outcomes in patients with metastatic breast cancer receiving endocrine-based therapy. METHODS: Baseline CT scans were collected from ECOG-ACRIN E2112, a randomized phase III placebo-controlled study of exemestane with or without entinostat...
September 2023: Journal of the National Comprehensive Cancer Network: JNCCN
https://read.qxmd.com/read/37652957/mendelian-randomization-analysis-revealed-potential-metabolic-causal-factors-for-breast-cancer
#38
JOURNAL ARTICLE
Mengshi Zhou, Mason Henricks, Valerie Loch, Gloria Zhang, Yong Lu, Xiaoyin Li
Observational studies showed that metabolic phenotypes were associated with the risk of developing breast cancer (BC). However, those results are inconsistent regarding the magnitude of the association, particularly by subtypes of breast cancer. Furthermore, the mechanisms of the association remain unclear. We performed two-sample Mendelian randomization (MR) analyses to evaluate the causal effect of metabolic risk factors on breast cancer in the European population. Assessed individually using MR, body mass index (BMI) (odds ratio [OR] 0...
August 31, 2023: Scientific Reports
https://read.qxmd.com/read/37628945/increased-expression-of-mir-223-3p-and-mir-375-3p-and-anti-inflammatory-activity-in-hdl-of-newly-diagnosed-women-in-advanced-stages-of-breast-cancer
#39
JOURNAL ARTICLE
Monique de Fatima Mello Santana, Maria Isabela Bloise Alves Caldas Sawada, Aritania Sousa Santos, Mozania Reis, Jacira Xavier, Maria Lúcia Côrrea-Giannella, Andrea Harumy de Lima Hirata, Luiz Henrique Gebrim, Francisco Garcia Soriano, Cleber Pinto Camacho, Marisa Passarelli
The expression of inflammation-related miRs bound to high-density lipoproteins (HDLs), the anti-inflammatory activity of HDLs isolated from individuals with breast cancer, and controls were determined. Forty newly diagnosed women with breast cancer naïve of treatment and 10 control participants were included. Cholesterol-loaded bone-marrow-derived macrophages were incubated with HDL from both groups and challenged with lipopolysaccharide (LPS). Interleukin 6 (IL6) and tumor necrosis factor (TNF) in the medium were quantified...
August 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37546243/metabolic-profile-and-negatively-association-between-insulin-resistance-and-metastatic-incidence-in-indonesian-primary-invasive-breast-cancer-a-cross-sectional-study
#40
JOURNAL ARTICLE
Andhika Rachman, Zaenal Hakiki Fiantoro, Noorwati Sutandyo, Dimas Priantono, Pradana Zaky Romadhon, Reganedgary Jonlean
INTRODUCTION: Metastatic breast cancer was associated with high morbidity and mortality. Insulin resistance was hypothesized to be related to the incidence of advanced breast cancer. Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and Triglyceride/Glucose Index (TyG Index) are two metrics used to measure the degree of insulin resistance. This study aims to assess the relationship between the incidence of metastatic breast cancer and insulin resistance as reflected by both metrics...
2023: International Journal of General Medicine
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