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https://www.readbyqxmd.com/read/29743035/mammographic-density-changes-in-surgical-weight-loss-an-indication-for-personalized-screening
#1
Natalia Partain, Ali Mokdad, Nancy Puzziferri, Jessica Porembka, Stephen Seiler, Alana Christie, Deborah Farr, Aeisha Rivers, A Marilyn Leitch, Rachel Wooldridge, James Huth, Roshni Rao
BACKGROUND: Obesity and high radiologic breast density independently increase breast cancer risk. We evaluated the effect of surgical weight loss on mammographic density (MD). METHODS: Patients undergoing bariatric surgery and screening mammography (MG) were identified, data regarding demographics, comorbidities, calculated and genetic breast cancer risk was collected. Patients had a MG before and after surgery. Fellowship-trained breast radiologists assigned Breast Imaging Reporting and Data System density categories...
May 9, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29669579/long-term-prognostic-implications-of-risk-factors-associated-with-tumor-size-a-case-study-of-women-regularly-attending-screening
#2
Fredrik Strand, Keith Humphreys, Johanna Holm, Mikael Eriksson, Sven Törnberg, Per Hall, Edward Azavedo, Kamila Czene
BACKGROUND: Breast cancer prognosis is strongly associated with tumor size at diagnosis. We aimed to identify factors associated with diagnosis of large (> 2 cm) compared to small tumors, and to examine implications for long-term prognosis. METHODS: We examined 2012 women with invasive breast cancer, of whom 1466 had screen-detected and 546 interval cancers that were incident between 2001 and 2008 in a population-based screening cohort, and followed them to 31 December 2015...
April 18, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29665850/common-genetic-variation-and-novel-loci-associated-with-volumetric-mammographic-density
#3
Judith S Brand, Keith Humphreys, Jingmei Li, Robert Karlsson, Per Hall, Kamila Czene
BACKGROUND: Mammographic density (MD) is a strong and heritable intermediate phenotype of breast cancer, but much of its genetic variation remains unexplained. METHODS: We conducted a genetic association study of volumetric MD in a Swedish mammography screening cohort (n = 9498) to identify novel MD loci. Associations with volumetric MD phenotypes (percent dense volume, absolute dense volume, and absolute nondense volume) were estimated using linear regression adjusting for age, body mass index, menopausal status, and six principal components...
April 17, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29658110/prenatal-diethylstilbestrol-des-exposure-and-mammographic-density
#4
William C Strohsnitter, Kimberly A Bertrand, Rebecca Troisi, Christopher G Scott, Andrea L Cheville, Robert N Hoover, Julie R Palmer, Celine M Vachon
In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. It is unknown whether it is associated with greater mammographic density, which strongly predicts breast cancer risk. A cohort of DES-exposed and unexposed women was assembled at the Mayo Clinic in 1975, and followed through 2012 as part of the National Cancer Institute's DES Follow-up Study. Mammographic density from 3,637 mammograms for 332 (222 DES-exposed, 110 unexposed) women in this cohort screened at the Mayo Clinic, Rochester between 1996 and 2015 were determined clinically using the Breast Imaging Reporting and Data System (BI-RADS)...
April 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29607854/risk-factors-for-breast-cancer-among-indian-women-a-case-control-study
#5
M P Antony, B Surakutty, T A Vasu, M Chisthi
Background: Breast cancer is the most common malignancy among females all over the world. The incidence of breast cancer is persistently on the rise due to urbanization and lifestyle changes. Although various risk factors have been suggested for estimating the risk of developing breast cancer, most of these have been studied in the Western population. A better understanding of local characteristics of risk factors may help in devising locally effective prevention strategies for breast cancer...
April 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29599399/molecular-breast-imaging-administered-activity-does-not-require-adjustment-based-on-patient-size
#6
Thuy D Tran, Lacey R Ellingson, Tiffinee N Swanson, Courtney M Solberg, Michael K O'Connor, Carrie B Hruska
Objective: At our institution, MBI is performed with 300 MBq Tc-99m sstamibi for all patients. For some nuclear medicine procedures, administered activity or imaging time is increased for patients of larger size in order to obtain adequate counts. Our objective was to assess whether uptake of Tc-99m sestamibi in the breast is influenced by patient size. Methods: Records from patients who underwent a clinical MBI examination between July - November 2016 were reviewed. Those in whom our standard injection and preparation techniques were followed were included in the analysis [3,4]...
March 29, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29554470/the-university-of-wisconsin-breast-cancer-epidemiology-simulation-model-an-update
#7
Oguzhan Alagoz, Mehmet Ali Ergun, Mucahit Cevik, Brian L Sprague, Dennis G Fryback, Ronald E Gangnon, John M Hampton, Natasha K Stout, Amy Trentham-Dietz
The University of Wisconsin Breast Cancer Epidemiology Simulation Model (UWBCS), also referred to as Model W, is a discrete-event microsimulation model that uses a systems engineering approach to replicate breast cancer epidemiology in the US over time. This population-based model simulates the lifetimes of individual women through 4 main model components: breast cancer natural history, detection, treatment, and mortality. A key feature of the UWBCS is that, in addition to specifying a population distribution in tumor growth rates, the model allows for heterogeneity in tumor behavior, with some tumors having limited malignant potential (i...
April 2018: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29524207/mri-background-parenchymal-enhancement-breast-density-and-serum-hormones-in-postmenopausal-women
#8
Jennifer D Brooks, Janice S Sung, Malcolm C Pike, Irene Orlow, Frank Z Stanczyk, Jonine L Bernstein, Elizabeth A Morris
Background parenchymal enhancement (BPE) is the degree to which normal breast tissue enhances on contrast-enhanced magnetic resonance imaging (MRI). MRI-density is a volumetric measure of breast density that is highly correlated with mammographic density, an established breast cancer risk factor. Endogenous estrogen concentrations are positively associated with postmenopausal breast cancer risk and BPE has been shown to be sensitive to hormonal exposures. The objective of our study was to examine the relationship between BPE and MRI-density and serum hormone concentrations in postmenopausal women...
March 9, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29520472/residential-traffic-noise-and-mammographic-breast-density-in-the-diet-cancer-and-health-cohort
#9
Nina Roswall, Zorana Jovanovic Andersen, My von Euler-Chelpin, Ilse Vejborg, Elsebeth Lynge, Steen Solvang Jensen, Ole Raaschou-Nielsen, Anne Tjønneland, Mette Sørensen
OBJECTIVES: Traffic is the most important source of community noise, and it has been proposed to be associated with a range of disease outcomes, including breast cancer. As mammographic breast density (MD) is one of the strongest risk factors for developing breast cancer, the present study investigated whether there is an association between residential exposure to traffic noise and MD in a Danish cohort. METHODS: We included women with reproductive and lifestyle information available from the Diet, Cancer, and Health cohort, who also participated in the Copenhagen Mammography Screening Programme (n = 5,260)...
May 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29516610/optimizing-the-target-detectability-of-cone-beam-ct-performed-in-image-guided-radiation-therapy-for-patients-of-different-body-sizes
#10
Ching-Ching Yang, Pei-Chieh Yu, Jau-Ming Ruan, Yu-Cheng Chen
PURPOSE: The target detectability of cone beam computed tomography (CBCT) performed in image-guided radiation therapy (IGRT) was investigated to achieve sufficient image quality for patient positioning over a course of treatment session while maintaining radiation exposure from CBCT imaging as low as reasonably achievable (ALARA). METHODS: Body CBCT scans operated in half-fan mode were acquired with three different protocols: CBCTlowD , CBCTmidD , and CBCThighD , which resulted in weighted CT dose index (CTDIw ) of 0...
March 8, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29500187/adiposity-at-age-10-and-mammographic-density-among-premenopausal-women
#11
Aliya Alimujiang, Kellie R Imm, Catherine M Appleton, Graham A Colditz, Catherine S Berkey, Adetunji T Toriola
Although childhood adiposity is inversely associated with breast cancer risk, the association of childhood adiposity with mammographic density in premenopausal women has not been adequately studied. We analyzed data from 365 premenopausal women who came in for screening mammography at Washington University (St. Louis, MO) from 2015 to 2016. Body size at age 10 was self-reported using somatotype pictogram. Body mass index (BMI) at age 10 was imputed using data from Growing Up Today Study. Volpara software was used to evaluate volumetric percent density (VPD), dense volume (DV), and nondense volume (NDV)...
May 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29475965/migration-history-language-acculturation-and-mammographic-breast-density
#12
Parisa Tehranifar, Carmen B Rodriguez, Ayana K April-Sanders, Elise Desperito, Karen M Schmitt
Background: Breast cancer incidence is lower in many U.S. ethnic minority and foreign-born population groups. Investigating whether migration and acculturation patterns in risk are reflected in disease biomarkers may help to elucidate the underlying mechanisms. Methods: We compared the distribution of breast cancer risk factors across U.S.-born white, African American and Hispanic women, and foreign-born Hispanic women ( n = 477, ages 40-64 years, 287 born in Caribbean countries). We used linear regression models to examine the associations of migration history and linguistic acculturation with mammographic breast density (MBD), measured using computer-assisted methods as percent and area of dense breast tissue...
May 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29444691/affinity-proteomic-profiling-of-plasma-for-proteins-associated-to-area-based-mammographic-breast-density
#13
Sanna Byström, Martin Eklund, Mun-Gwan Hong, Claudia Fredolini, Mikael Eriksson, Kamila Czene, Per Hall, Jochen M Schwenk, Marike Gabrielson
BACKGROUND: Mammographic breast density is one of the strongest risk factors for breast cancer, but molecular understanding of how breast density relates to cancer risk is less complete. Studies of proteins in blood plasma, possibly associated with mammographic density, are well-suited as these allow large-scale analyses and might shed light on the association between breast cancer and breast density. METHODS: Plasma samples from 1329 women in the Swedish KARMA project, without prior history of breast cancer, were profiled with antibody suspension bead array (SBA) assays...
February 14, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29435563/family-history-and-breast-cancer-risk-among-older-women-in-the-breast-cancer-surveillance-consortium-cohort
#14
Dejana Braithwaite, Diana L Miglioretti, Weiwei Zhu, Joshua Demb, Amy Trentham-Dietz, Brian Sprague, Jeffrey A Tice, Tracy Onega, Louise M Henderson, Diana S M Buist, Elad Ziv, Louise C Walter, Karla Kerlikowske
Importance: First-degree family history is a strong risk factor for breast cancer, but controversy exists about the magnitude of the association among older women. Objective: To determine whether first-degree family history is associated with increased risk of breast cancer among older women, and identify whether the association varies by breast density. Design, Setting, and Participants: Prospective cohort study between 1996 and 2012 from 7 Breast Cancer Surveillance Consortium (BCSC) registries located in New Hampshire, North Carolina, San Francisco Bay area, western Washington state, New Mexico, Colorado, and Vermont...
April 1, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29426615/low-childhood-high-density-lipoprotein-cholesterol-levels-and-subsequent-risk-for-chronic-inflammatory-bowel-disease
#15
Markku Voutilainen, Nina Hutri-Kähönen, Päivi Tossavainen, Taina Sipponen, Niina Pitkänen, Tomi Laitinen, Eero Jokinen, Tapani Rönnemaa, Jorma S A Viikari, Olli T Raitakari, Markus Juonala
BACKGROUND AND AIMS: Several genetic and environmental risk factors have been linked to chronic inflammatory bowel disease (IBD). The incidence of IBD has significantly increased in developed countries during last decades. The aim of the present study was to examine childhood risk factors for subsequent IBD diagnosis in a longitudinal cohort study of children and adolescents. METHODS: A Finnish study population consisting of 3551 children and adolescents originally evaluated as part of the Cardiovascular Risk in Young Finns study in 1980...
April 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29423438/breast-cancer-risk-factors-and-mammographic-density-among-high-risk-women-in-urban-china
#16
Hyuna Sung, Jiansong Ren, Jing Li, Ruth M Pfeiffer, Yong Wang, Jennifer L Guida, Yi Fang, Jufang Shi, Kai Zhang, Ni Li, Shen Wang, Luopei Wei, Nan Hu, Gretchen L Gierach, Min Dai, Xiaohong R Yang, Jie He
Elevated mammographic density (MD) is an established breast cancer risk factor. Studies examining relationships between MD and breast cancer risk factors are limited in China, where established breast cancer risk factors are less prevalent but dense breasts are more prevalent than Western countries. This study included 11,478 women (45-69 years; 36% premenopausal) participating in an ongoing national cancer screening program in 11 urban provinces in China and predicted as having high-risk for breast cancer...
2018: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29402289/a-comparison-of-five-methods-of-measuring-mammographic-density-a-case-control-study
#17
Susan M Astley, Elaine F Harkness, Jamie C Sergeant, Jane Warwick, Paula Stavrinos, Ruth Warren, Mary Wilson, Ursula Beetles, Soujanya Gadde, Yit Lim, Anil Jain, Sara Bundred, Nicola Barr, Valerie Reece, Adam R Brentnall, Jack Cuzick, Tony Howell, D Gareth Evans
BACKGROUND: High mammographic density is associated with both risk of cancers being missed at mammography, and increased risk of developing breast cancer. Stratification of breast cancer prevention and screening requires mammographic density measures predictive of cancer. This study compares five mammographic density measures to determine the association with subsequent diagnosis of breast cancer and the presence of breast cancer at screening. METHODS: Women participating in the "Predicting Risk Of Cancer At Screening" (PROCAS) study, a study of cancer risk, completed questionnaires to provide personal information to enable computation of the Tyrer-Cuzick risk score...
February 5, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29378534/vertebral-fractures-among-breast-cancer-survivors-in-china-a-cross-sectional-study-of-prevalence-and-health-services-gaps
#18
Evelyn Hsieh, Qin Wang, Renzhi Zhang, Xin Niu, Weibo Xia, Liana Fraenkel, Karl L Insogna, Jing Li, Jennifer S Smith, Chunwu Zhou, You-Lin Qiao, Pin Zhang
BACKGROUND: Breast cancer survivors are at high risk for fracture due to cancer treatment-induced bone loss, however, data is scarce regarding the scope of this problem from an epidemiologic and health services perspective among Chinese women with breast cancer. METHODS: We designed a cross-sectional study comparing prevalence of vertebral fractures among age- and BMI-matched women from two cohorts. Women in the Breast Cancer Survivors cohort were enrolled from a large cancer hospital in Beijing...
January 30, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29376548/vitamin-d-levels-in-swiss-breast-cancer-survivors
#19
Michael Baumann, Sergio Ulhoa Dani, Daniel Dietrich, Andreas Hochstrasser, Dirk Klingbiel, Michael Thomas Mark, Walter F Riesen, Thomas Ruhstaller, Arnoud J Templeton, Beat Thürlimann
BACKGROUND: Cholecalciferol (vitamin D3) is widely supplemented in breast cancer survivors because of the role of vitamin D in multiple health outcomes. METHODS: We conducted an observational study in 332 women in Eastern Switzerland with early, i.e., nonmetastatic breast cancer. Tumour-, patient-related and sociodemographic variables were recorded. Cholecalciferol intake and serum 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) levels were measured at the first visit (baseline) and during a follow-up visit in a median of 210 days (range 87-857) after the first visit...
January 29, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29330698/circulating-hormones-and-mammographic-density-in-premenopausal-women
#20
Kimberly A Bertrand, A Heather Eliassen, Susan E Hankinson, Bernard A Rosner, Rulla M Tamimi
Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic density (MD) in premenopausal women. We conducted a cross-sectional study of plasma hormone levels in relation to MD among 634 cancer-free premenopausal women in the Nurses' Health Study II. We measured percent MD from screening mammograms using a computer-assisted method. We assayed estradiol, estrone, and estrone sulfate in blood samples timed in early follicular and mid-luteal phases of the menstrual cycle as well as testosterone, androstenedione, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate, sex hormone-binding globulin (SHBG), and anti-Müllerian hormone in luteal or untimed samples...
April 2018: Hormones & Cancer
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