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https://www.readbyqxmd.com/read/29330698/circulating-hormones-and-mammographic-density-in-premenopausal-women
#1
Kimberly A Bertrand, A Heather Eliassen, Susan E Hankinson, Bernard A Rosner, Rulla M Tamimi
Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic density (MD) in premenopausal women. We conducted a cross-sectional study of plasma hormone levels in relation to MD among 634 cancer-free premenopausal women in the Nurses' Health Study II. We measured percent MD from screening mammograms using a computer-assisted method. We assayed estradiol, estrone, and estrone sulfate in blood samples timed in early follicular and mid-luteal phases of the menstrual cycle as well as testosterone, androstenedione, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate, sex hormone-binding globulin (SHBG), and anti-Müllerian hormone in luteal or untimed samples...
January 12, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29258587/association-between-mammographic-breast-density-and-histologic-features-of-benign-breast-disease
#2
Karthik Ghosh, Robert A Vierkant, Ryan D Frank, Stacey Winham, Daniel W Visscher, Vernon S Pankratz, Christopher G Scott, Kathleen Brandt, Mark E Sherman, Derek C Radisky, Marlene H Frost, Lynn C Hartmann, Amy C Degnim, Celine M Vachon
BACKGROUND: Over 40% of women undergoing breast screening have mammographically dense breasts. Elevated mammographic breast density (MBD) is an established breast cancer risk factor and is known to mask tumors within the dense tissue. However, the association of MBD with high risk benign breast disease (BBD) is unknown. METHOD: We analyzed data for 3400 women diagnosed with pathologically confirmed BBD in the Mayo Clinic BBD cohort from 1985-2001, with a clinical MBD measure (either parenchymal pattern (PP) or Breast Imaging Reporting and Data Systems (BI-RADS) density) and expert pathology review...
December 19, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29246131/mammographic-density-and-risk-of-breast-cancer-by-tumor-characteristics-a-case-control-study
#3
Kavitha Krishnan, Laura Baglietto, Jennifer Stone, Catriona McLean, Melissa C Southey, Dallas R English, Graham G Giles, John L Hopper
BACKGROUND: In a previous paper, we had assumed that the risk of screen-detected breast cancer mostly reflects inherent risk, and the risk of whether a breast cancer is interval versus screen-detected mostly reflects risk of masking. We found that inherent risk was predicted by body mass index (BMI) and dense area (DA) or percent dense area (PDA), but not by non-dense area (NDA). Masking, however, was best predicted by PDA but not BMI. In this study, we aimed to investigate if these associations vary by tumor characteristics and mode of detection...
December 16, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29235933/faster-ticking-rate-of-the-epigenetic-clock-is-associated-with-faster-pubertal-development-in-girls
#4
Alexandra M Binder, Camila Corvalan, Verónica Mericq, Ana Pereira, José Luis Santos, Steve Horvath, John Shepherd, Karin B Michels
Epigenetic age is an indicator of biological aging, capturing the impact of environmental and behavioral influences across time on cellular function. Deviance between epigenetic age and chronological age (AgeAccel) is a predictor of health. Pubertal timing has similarly been associated with cancer risk and mortality rate among females. We examined the association between AgeAccel and pubertal timing and adolescent breast composition in the longitudinal Growth and Obesity Cohort Study. AgeAccel was estimated in whole blood using the Horvath method at breast Tanner 2 (B2) and 4 (B4)...
December 13, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29201827/lumbar-scoliosis-in-patients-with-breast-cancer-prevalence-and-relationship-with-breast-cancer-treatment-age-bone-mineral-density-and-body-mass-index
#5
Sangeun Jung, Mee Gang Kim, Jong In Lee
Objective: To identify the prevalence of lumbar scoliosis in breast cancer patients and to investigate the potential risk factors of lumbar scoliosis. Methods: A retrospective chart review was performed in breast cancer patients aged more than 40 years who underwent dual energy X-ray absorptiometry (DEXA) scanning between January 2014 and December 2014. We divided the patients into control and experimental groups in order to investigate the influence of breast cancer treatment...
October 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29190506/mammographic-density-and-breast-cancer-risk-in-breast-screening-assessment-cases-and-women-with-a-family-history-of-breast-cancer
#6
Stephen W Duffy, Oliver W E Morrish, Prue C Allgood, Richard Black, Maureen G C Gillan, Paula Willsher, Julie Cooke, Karen A Duncan, Michael J Michell, Hilary M Dobson, Roberta Maroni, Yit Y Lim, Hema N Purushothaman, Tamara Suaris, Susan M Astley, Kenneth C Young, Lorraine Tucker, Fiona J Gilbert
BACKGROUND: Mammographic density has been shown to be a strong independent predictor of breast cancer and a causative factor in reducing the sensitivity of mammography. There remain questions as to the use of mammographic density information in the context of screening and risk management, and of the association with cancer in populations known to be at increased risk of breast cancer. AIM: To assess the association of breast density with presence of cancer by measuring mammographic density visually as a percentage, and with two automated volumetric methods, Quantra™ and VolparaDensity™...
January 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29170810/correlation-study-between-osteoporosis-and-hematopoiesis-in-the-context-of-adjuvant-chemotherapy-for-breast-cancer
#7
Frédérica Schyrr, Anita Wolfer, Jérôme Pasquier, Anne-Laure Nicoulaz, Olivier Lamy, Olaia Naveiras
This retrospective study attempts to establish if a correlation exists between osteoporosis and hematopoiesis before and after adjuvant chemotherapy in the context of non-metastatic breast cancer. Osteoporosis is interpreted both as a direct marker of osteoblastic decline and as an indirect marker of increased bone marrow adiposity within the hematopoietic microenvironment. Patients from the "Centre du Sein" at CHUV (Centre Hospitalier Universitaire Vaudois) undergoing adjuvant chemotherapy were included in this study...
November 23, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29167285/macrophagic-crown-like-structures-are-associated-with-an-increased-risk-of-breast-cancer-in-benign-breast-disease
#8
Jodi M Carter, Tanya L Hoskin, M Alvaro Pena, Rushin Brahmbhatt, Stacey J Winham, Marlene H Frost, Melody Stallings-Mann, Derek C Radisky, Keith L Knutson, Daniel W Visscher, Amy C Degnim
In breast adipose tissue, macrophages that encircle damaged adipocytes form "crown-like structures of breast" (CLS-B). While CLS-B have been associated with breast cancer, their role in benign breast disease and early carcinogenesis is not understood. We evaluated breast biopsies from three age-matched groups (n = 86 each, mean age 55 y), including normal tissue donors of the Susan G. Komen for the Cure® Tissue Bank (KTB), and subjects in the Mayo Clinic Benign Breast Disease (BBD) Cohort who developed cancer (BBD cases) or did not develop cancer (BBD controls, median follow-up 14 y)...
November 22, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29144164/correlation-between-obesity-and-fat-infiltrated-axillary-lymph-nodes-visualized-on-mammography
#9
Roberta Maria M diFlorio Alexander, Steffen J Haider, Todd MacKenzie, Martha E Goodrich, Julie Weiss, Tracy Onega
OBJECTIVE: Using screening mammography, this study investigated the association between obesity and axillary lymph node (LN) size and morphology. METHODS: We conducted a retrospective review of 188 women who underwent screening mammography at an academic medical center. Length and width of the LN and hilum were measured in the largest, mammographically visible axillary node. The hilo-cortical ratio (HCR) was calculated as the hilar width divided by the cortical width...
November 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29139618/beyond-sarcopenia-characterization-and-integration-of-skeletal-muscle-quantity-and-radiodensity-in-a-curable-breast-cancer-population
#10
Marc S Weinberg, Shlomit S Shachar, Hyman B Muss, Allison M Deal, Karteek Popuri, Hyeon Yu, Kirsten A Nyrop, Shani M Alston, Grant R Williams
Skeletal muscle loss, commonly known as sarcopenia, is highly prevalent and prognostic of adverse outcomes in oncology. However, there is limited information on adults with early breast cancer and examination of other skeletal muscle indices, despite the potential prognostic importance. This study characterizes and examines age-related changes in body composition of adults with early breast cancer and describes the creation of a novel integrated muscle measure. Female patients diagnosed with stage I-III breast cancer with abdominal computerized tomography (CT) scans within 12 weeks from diagnosis were identified from local tumor registry (N = 241)...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29098437/breast-compression-parameters-and-mammographic-density-in-the-norwegian-breast-cancer-screening-programme
#11
Nataliia Moshina, Marta Roman, Gunvor G Waade, Sofie Sebuødegård, Giske Ursin, Solveig Hofvind
OBJECTIVES: To investigate possible associations between breast compression parameters, including compression force, pressure and compressed breast thickness, and mammographic density assessed by an automated software. METHODS: We obtained data on breast compression parameters, breast volume, absolute and percentage dense volume, and body mass index for 14,698 women screened with two-view (craniocaudal, CC, and mediolateral oblique, MLO) digital mammography, in the Norwegian Breast Cancer Screening Programme, 2014-2015...
November 2, 2017: European Radiology
https://www.readbyqxmd.com/read/29074552/occupational-exposures-and-mammographic-density-in-spanish-women
#12
Virginia Lope, Javier García-Pérez, Beatriz Pérez-Gómez, Ana María Pedraza-Flechas, Juan Alguacil, Mª Carmen González-Galarzo, Miguel Angel Alba, Rudolf van der Haar, Rosa Ana Cortés-Barragán, Carmen Pedraz-Pingarrón, Pilar Moreo, Carmen Santamariña, María Ederra, Carmen Vidal, Dolores Salas-Trejo, Carmen Sánchez-Contador, Rafael Llobet, Marina Pollán
OBJECTIVES: The association between occupational exposures and mammographic density (MD), a marker of breast cancer risk, has not been previously explored. Our objective was to investigate the influence of occupational exposure to chemical, physical and microbiological agents on MD in adult women. METHODS: This is a population-based cross-sectional study based on 1476 female workers aged 45-65 years from seven Spanish breast cancer screening programmes. Occupational history was surveyed by trained staff...
October 26, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29063662/breast-density-in-multiethnic-women-presenting-for-screening-mammography
#13
Bridget A Oppong, Chiranjeev Dash, Suzanne O'Neill, Yinan Li, Kepher Makambi, Edward Pien, Erini Makariou, Tesha Coleman, Lucile L Adams-Campbell
Data on ethnic variations in breast density are limited and often not inclusive of underrepresented minorities. As breast density is associated with elevated breast cancer risk, investigating racial and ethnic difference may elucidate the observed differences in breast cancer risk among different populations. We reviewed breast density from initial screening of women from the Capital Breast Care Center and Georgetown University Hospital from 2010 to 2014. Patient demographics including race, age at screening, education, menopausal status, and body mass index were abstracted...
October 24, 2017: Breast Journal
https://www.readbyqxmd.com/read/29040039/breast-cancer-risk-associations-with-digital-mammographic-density-by-pixel-brightness-threshold-and-mammographic-system
#14
Tuong L Nguyen, Yoon-Ho Choi, Ye K Aung, Christopher F Evans, Nhut H Trinh, Shuai Li, Gillian S Dite, Myeong-Seong Kim, Patrick C Brennan, Mark A Jenkins, Joohon Sung, Yun-Mi Song, John L Hopper
Purpose To compare three mammographic density measures defined by different pixel intensity thresholds as predictors of breast cancer risk for two different digital mammographic systems. Materials and Methods The Korean Breast Cancer Study included 398 women with invasive breast cancer and 737 control participants matched for age at mammography (±1 year), examination date, mammographic system, and menopausal status. Mammographic density was measured by using the automated Laboratory for Individualized Breast Radiodensity Assessment (LIBRA) software and the semiautomated Cumulus software at the conventional threshold (Cumulus) and at increasingly higher thresholds (Altocumulus and Cirrocumulus, respectively)...
October 16, 2017: Radiology
https://www.readbyqxmd.com/read/28957821/association-between-mammographic-density-and-tumor-marker-defined-breast-cancer-subtypes-a-case-control-study
#15
Jinyoung Shin, Jeong Eon Lee, Hyeon Young Ko, Tuong Linh Nguyen, Seok Jin Nam, John Llewelyn Hopper, Yun-Mi Song
High mammographic density (MD) is the most important risk factor for breast cancer. This study aimed to clarify the relationship between MD and breast cancer subtypes defined by tumor markers. We enrolled 642 women with breast cancer (69% premenopausal) and 1241 controls matched for age and menopausal status. Absolute mammographic dense area (ADA), percent mammographic dense area (PDA), and nondense area were assessed using a computer-assisted thresholding technique. We classified breast cancer cases into four subtypes using information on tumor marker expression such as estrogen receptor (ER), progesterone receptor (PR), and Cerb2 receptor (HER2); luminal A (ER+ and/or PR+, HER2-), luminal B (ER+ and/or PR+, HER2+), HER2-overexpressing (ER-, PR-, and HER2+), and triple-negative (ER-, PR-, and HER2-)...
September 27, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28952021/mammographic-appearances-in-mongolia-causal-factors-for-varying-densities
#16
D Demchig, C Mello-Thoms, Kh Khulan, A Ramish, P C Brennan
Objective: Mammographic density (MD) is a significant risk factor for breast cancer and an important determinant for establishing efficiency of any screening program. Currently, the distribution and influential factors of MD is unknown among Mongolian women. This work aims to characterize MD of Mongolian women. Methods: The ethical approval was obtained from Research Ethics Board of the University of Sydney (2014/973) and National Ethic Committee from Ministry of Mongolia (2015/04). We recruited 1985 women aged 16-83 from the National Cancer Center in Mongolia for whom MD and age of each woman was known...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28904061/a-randomized-controlled-trial-of-green-tea-extract-supplementation-and-mammographic-density-in-postmenopausal-women-at-increased-risk-of-breast-cancer
#17
Hamed Samavat, Giske Ursin, Tim H Emory, Eunjung Lee, Renwei Wang, Carolyn J Torkelson, Allison M Dostal, Karen Swenson, Chap T Le, Chung S Yang, Mimi C Yu, Douglas Yee, Anna H Wu, Jian-Min Yuan, Mindy S Kurzer
Epidemiological and animal studies suggest a protective role of green tea against breast cancer. However the underlying mechanism is not understood. We conducted a randomized, double-blinded, placebo-controlled phase II clinical trial to investigate whether supplementation with green tea extract (GTE) modifies mammographic density (MD), as a potential mechanism, involving 1,075 healthy postmenopausal women. Women assigned to the treatment arm consumed daily 4 decaffeinated GTE capsules containing 1315 mg total catechins including 843 mg epigallocatechin-3-gallate (EGCG) for 12 months...
September 13, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28843166/occupation-and-mammographic-density-a-population-based-study-ddm-occup
#18
MULTICENTER STUDY
Javier García-Pérez, Marina Pollán, Beatriz Pérez-Gómez, Mario González-Sánchez, Rosa Ana Cortés Barragán, Jerónimo Maqueda Blasco, María Carmen González-Galarzo, Miguel Ángel Alba, Rudolf van der Haar, Silvia Casas, Cándida Vicente, Pilar Medina, María Ederra, Carmen Santamariña, María Pilar Moreno, Francisco Casanova, Carmen Pedraz-Pingarrón, Pilar Moreo, Nieves Ascunce, Montse García, Dolores Salas-Trejo, Carmen Sánchez-Contador, Rafael Llobet, Virginia Lope
INTRODUCTION: High mammographic density is one of the main risk factors for breast cancer. Although several occupations have been associated with breast cancer, there are no previous occupational studies exploring the association with mammographic density. Our objective was to identify occupations associated with high mammographic density in Spanish female workers. METHODS: We conducted a population-based cross-sectional study of occupational determinants of high mammographic density in Spain, based on 1476 women, aged 45-68 years, recruited from seven screening centers within the Spanish Breast Cancer Screening Program network...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28830497/combining-quantitative-and-qualitative-breast-density-measures-to-assess-breast-cancer-risk
#19
Karla Kerlikowske, Lin Ma, Christopher G Scott, Amir P Mahmoudzadeh, Matthew R Jensen, Brian L Sprague, Louise M Henderson, V Shane Pankratz, Steven R Cummings, Diana L Miglioretti, Celine M Vachon, John A Shepherd
BACKGROUND: Accurately identifying women with dense breasts (Breast Imaging Reporting and Data System [BI-RADS] heterogeneously or extremely dense) who are at high breast cancer risk will facilitate discussions of supplemental imaging and primary prevention. We examined the independent contribution of dense breast volume and BI-RADS breast density to predict invasive breast cancer and whether dense breast volume combined with Breast Cancer Surveillance Consortium (BCSC) risk model factors (age, race/ethnicity, family history of breast cancer, history of breast biopsy, and BI-RADS breast density) improves identifying women with dense breasts at high breast cancer risk...
August 22, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28828694/association-between-mammographic-density-and-pregnancies-relative-to-age-and-bmi-a-breast-cancer-case-only-analysis
#20
Carolin C Hack, Julius Emons, Sebastian M Jud, Katharina Heusinger, Werner Adler, Paul Gass, Lothar Haeberle, Felix Heindl, Alexander Hein, Rüdiger Schulz-Wendtland, Michael Uder, Arndt Hartmann, Matthias W Beckmann, Peter A Fasching, Uwe G Pöhls
PURPOSE: Percentage mammographic density (PMD) is a major risk factor for breast cancer (BC). It is strongly associated with body mass index (BMI) and age, which are themselves risk factors for breast cancer. This analysis investigated the association between the number of full-term pregnancies and PMD in different subgroups relative to age and BMI. METHODS: Patients were identified in the breast cancer database of the University Breast Center for Franconia. A total of 2410 patients were identified, for whom information on parity, age, and BMI, and a mammogram from the time of first diagnosis were available for assessing PMD...
August 21, 2017: Breast Cancer Research and Treatment
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