Read by QxMD icon Read

breast density bmi

Rachel Denholm, Bianca De Stavola, John H Hipwell, Simon J Doran, Marta C Busana, Amanda Eng, Mona Jeffreys, Martin O Leach, David Hawkes, Isabel Dos Santos Silva
BACKGROUND: Breast density, the amount of fibroglandular tissue in the adult breast for a women's age and body mass index, is a strong biomarker of susceptibility to breast cancer, which may, like breast cancer risk itself, be influenced by events early in life. In the present study, we investigated the association between pre-natal exposures and breast tissue composition. METHODS: A sample of 500 young, nulliparous women (aged approximately 21 years) from a U...
October 12, 2016: Breast Cancer Research: BCR
F N Fjeldheim, H Frydenberg, V G Flote, A McTiernan, A-S Furberg, P T Ellison, E S Barrett, T Wilsgaard, G Jasienska, G Ursin, E A Wist, I Thune
BACKGROUND: Single nucleotide polymorphisms (SNPs) involved in the estrogen pathway and SNPs in the estrogen receptor alpha gene (ESR1 6q25) have been linked to breast cancer development, and mammographic density is an established breast cancer risk factor. Whether there is an association between daily estradiol levels, SNPs in ESR1 and premenopausal mammographic density phenotypes is unknown. METHODS: We assessed estradiol in daily saliva samples throughout an entire menstrual cycle in 202 healthy premenopausal women in the Norwegian Energy Balance and Breast Cancer Aspects I study...
October 7, 2016: BMC Cancer
Fredrik Strand, Keith Humphreys, Abbas Cheddad, Sven Törnberg, Edward Azavedo, John Shepherd, Per Hall, Kamila Czene
BACKGROUND: Interval breast cancers are often diagnosed at a more advanced stage than screen-detected cancers. Our aim was to identify features in screening mammograms of the normal breast that would differentiate between future interval cancers and screen-detected cancers, and to understand how each feature affects tumor detectability. METHODS: From a population-based cohort of invasive breast cancer cases in Stockholm-Gotland, Sweden, diagnosed from 2001 to 2008, we analyzed the contralateral mammogram at the preceding negative screening of 394 interval cancer cases and 1009 screen-detected cancers...
October 5, 2016: Breast Cancer Research: BCR
Mark Sak, Neb Duric, Peter Littrup, Lisa Bey-Knight, Haythem Ali, Patricia Vallieres, Mark E Sherman, Gretchen L Gierach
A population of 165 women with negative mammographic screens also received an ultrasound tomography (UST) examination at the Karmanos Cancer Institute in Detroit, MI. Standard statistical techniques were employed to measure the associations between the various mammographic- and UST-related density measures and various participant characteristics such as age, weight and height. The mammographic percent density (MPD) was found to have similar strength associations with UST mean sound speed (Spearman coefficient, rs = 0...
September 29, 2016: Ultrasound in Medicine & Biology
Elisa Maseroli, Egidia Fanni, Sarah Cipriani, Irene Scavello, Francesca Pampaloni, Cesare Battaglia, Massimiliano Fambrini, Edoardo Mannucci, Emmanuele A Jannini, Mario Maggi, Linda Vignozzi
INTRODUCTION: The relation between sexual and cardiovascular health in women is not well defined. Clitoral color Doppler ultrasound (CDU) with assessment of the pulsatility index (PI), reflecting resistance to blood flow, has been proposed as an objective measurement of sexual functioning. AIM: To investigate associations between clitoral PI and cardiometabolic risk factors, sexual and intrapsychic parameters, and self-perception of body image. METHODS: Seventy-one adult heterosexual women in a stable relationship attending our clinic for sexual dysfunction were consecutively recruited...
September 27, 2016: Journal of Sexual Medicine
Marta Cecilia Busana, Amanda Eng, Rachel Denholm, Mitch Dowsett, Sarah Vinnicombe, Steve Allen, Isabel Dos-Santos-Silva
BACKGROUND: Full-field digital mammography, which is gradually being introduced in most clinical and screening settings, produces two types of images: raw and processed. However, the extent to which mammographic density measurements, and their ability to predict breast cancer risk, vary according to type of image is not fully known. METHODS: We compared the performance of the semi-automated Cumulus method on digital raw, "analogue-like" raw and processed images, and the performance of a recently developed method - Laboratory for Breast Radiodensity Assessment (LIBRA) - on digital raw and processed images, in a case-control study (414 patients (cases) and 684 controls) by evaluating the extent to which their measurements were associated with breast cancer risk factors, and by comparing their ability to predict breast cancer risk...
September 26, 2016: Breast Cancer Research: BCR
Terryl J Hartman, Susan M Gapstur, Mia M Gaudet, Roma Shah, W Dana Flanders, Ying Wang, Marjorie L McCullough
BACKGROUND: Dietary energy density (ED) is a measure of diet quality that estimates the amount of energy per unit of food (kilocalories per gram) consumed. Low-ED diets are generally high in fiber and fruits and vegetables and low in fat. Dietary ED has been positively associated with body mass index (BMI) and other risk factors for postmenopausal breast cancer. OBJECTIVE: We evaluated the associations of total dietary ED and energy-dense (high-ED) foods with postmenopausal breast cancer incidence...
October 2016: Journal of Nutrition
Fredrik Strand, Keith Humphreys, Mikael Eriksson, Jingmei Li, Therese Ml Andersson, Sven Törnberg, Edward Azavedo, John Shepherd, Per Hall, Kamila Czene
Interval breast cancer (IC) has a more aggressive phenotype and higher mortality than screen-detected cancer (SDC). In this case-case study, we investigated whether the size of longitudinal fluctuations in mammographic percent density (PD fluctuation) was associated with the ratio of IC vs. SDC among screened women with breast cancer. The primary study population consisted of 1,414 postmenopausal breast cancer cases, and the validation population of 1,241 cases. We calculated PD fluctuation as the quadratic mean of deviations between actual PD and the long-term trend estimated by a mixed effects model...
September 12, 2016: International Journal of Cancer. Journal International du Cancer
Abra M Jeffers, Weiva Sieh, Jafi A Lipson, Joseph H Rothstein, Valerie McGuire, Alice S Whittemore, Daniel L Rubin
Purpose To compare three metrics of breast density on full-field digital mammographic (FFDM) images as predictors of future breast cancer risk. Materials and Methods This institutional review board-approved study included 125 women with invasive breast cancer and 274 age- and race-matched control subjects who underwent screening FFDM during 2004-2013 and provided informed consent. The percentage of density and dense area were assessed semiautomatically with software (Cumulus 4.0; University of Toronto, Toronto, Canada), and volumetric percentage of density and dense volume were assessed automatically with software (Volpara; Volpara Solutions, Wellington, New Zealand)...
September 5, 2016: Radiology
Cecilia W Huo, Dexing Huang, Grace L Chew, Prue Hill, Ambika Vohora, Wendy V Ingman, Danielle J Glynn, Nathan Godde, Michael A Henderson, Erik W Thompson, Kara L Britt
Women with high mammographic density (MD) are at increased risk of breast cancer (BC) after adjustment for age and body mass index. We have developed a murine biochamber model in which both high MD (HMD) and low MD (LMD) tissue can be propagated. Here, we tested whether cells isolated by collagenase digestion and fluorescence-activated cell sorting (FACS) from normal breast can be reconstituted in our biochamber model, which would allow cell-specific manipulations to be tested. Fresh breast tissue was collected from women (n = 7) undergoing prophylactic mastectomy...
November 2016: Cell Biology International
Jennifer Gillman, Jennifer Chun, Shira Schwartz, Freya Schnabel, Linda Moy
PURPOSE: The purpose was to evaluate the relationship between body mass index (BMI), mammographic breast density, magnetic resonance (MR) background parenchymal enhancement (BPE), and MR fibroglandular tissue (FGT) in women with breast cancer. METHODS: Our institutional database was queried for patients with preoperative mammography and breast MR imaging. RESULTS: There were 573 women eligible for analysis. Elevated BMI was associated with advanced stage of disease (P=...
August 12, 2016: Clinical Imaging
Amina Amadou, Carine Biessy, Sabina Rinaldi, Veronika Fedirko, Nada Assi, Martin Lajous, Eduardo Ortiz-Panozo, Elsa Yunes, Ruy Lopez-Ridaura, Gabriela Torres-Mejia, Isabelle Romieu
Low circulating levels of vitamin D and high mammographic density (MD) have been associated with higher risk of breast cancer. Although some evidence suggested an inverse association between circulating vitamin D and MD, no studies have investigated this association among Mexican women. We examined whether serum 25-hydroxyvitamin D3 [25(OH)D3] levels were associated with MD in a cross-sectional study nested within the large Mexican Teacher's Cohort. This study included 491 premenopausal women with a mean age of 42...
2016: PloS One
Ashley S Felix, Petra Lenz, Ruth M Pfeiffer, Stephen M Hewitt, Jennifer Morris, Deesha A Patel, Berta Geller, Pamela M Vacek, Donald L Weaver, Rachael E Chicoine, John Shepherd, Amir Pasha Mahmoudzadeh, Jeff Wang, Bo Fan, Serghei Malkov, Sally D Herschorn, Jason M Johnson, Renata L Cora, Louise A Brinton, Mark E Sherman, Gretchen L Gierach
BACKGROUND: Women with high levels of mammographic density (MD) have a four- to six-fold increased risk of developing breast cancer; however, most neither have a prevalent tumor nor will they develop one. Magnetic resonance imaging (MRI) studies suggest that background parenchymal enhancement, an indicator of vascularity, is related to increased breast cancer risk. Correlations of microvessel density (MVD) in tissue, MD and biopsy diagnosis have not been defined, and we investigated these relationships among 218 women referred for biopsy...
2016: Breast Cancer Research: BCR
Leslie V Farland, Rulla M Tamimi, A Heather Eliassen, Donna Spiegelman, Kimberly A Bertrand, Stacey A Missmer
PURPOSE: Endometriosis and mammographic density have been hypothesized to be influenced by sex steroid hormonal exposures in adolescence and early adulthood. We investigated the association between endometriosis and mammographic density, a consistent and independent risk factor for breast cancer. METHODS: We conducted a cross-sectional analysis among 1,581 pre- and postmenopausal women not previously diagnosed with breast cancer in the Nurses' Health Study II cohort...
October 2016: Cancer Causes & Control: CCC
Adela Castelló, Nieves Ascunce, Dolores Salas-Trejo, Carmen Vidal, Carmen Sanchez-Contador, Carmen Santamariña, Carmen Pedraz-Pingarrón, Maria Pilar Moreno, Beatriz Pérez-Gómez, Virginia Lope, Nuria Aragonés, Jesús Vioque, Marina Pollán
OBJECTIVE: To examine the association between two dietary patterns (Western and Mediterranean), previously linked to breast cancer risk, and mammographic density. METHODS: This cross-sectional study included 3,584 women attending population-based breast cancer screening programs and recruited between October 7, 2007, and July 14, 2008 (participation rate 74.5%). Collected data included anthropometric measurements; demographic, obstetric, and gynecologic characteristics; family and personal health history; and diet in the preceding year...
September 2016: Obstetrics and Gynecology
Tomi F Akinyemiju, Parisa Tehranifar, Julie D Flom, Yuyan Liao, Ying Wei, Mary Beth Terry
PURPOSE: Rapid infant and childhood growth has been associated with chronic disease later in life, including breast cancer. Early life socioeconomic status (SES) influences childhood growth, but few studies have prospective measures from birth to consider the effects of early life growth and SES on breast cancer risk. METHODS: We used prospectively measured early life SES and growth (percentile weight change in height and weight between each pair of consecutive time points at birth, 4 months, 1 and 7 years)...
August 2016: Annals of Epidemiology
Ji-Hyun So, Jung-Kwon Lee, Jin-Young Shin, Wan Park
BACKGROUND: Cardiovascular disease is an important cause of morbidity and mortality in cancer survivors. The aim of this study was to investigate the modifiable cardiovascular disease risk factors and 10-year probability of the disease based on the Framingham risk score in cancer survivors, compared with the general population. METHODS: A total of 1,225 cancer survivors and 5,196 non-cancer controls who participated in the 2007-2013 Korea National Health and Nutrition Examination Surveys were enrolled...
July 2016: Korean Journal of Family Medicine
Jessica A Martinez, Pavani Chalasani, Cynthia A Thomson, Denise Roe, Maria Altbach, Jean-Philippe Galons, Alison Stopeck, Patricia A Thompson, Diana Evelyn Villa-Guillen, H-H Sherry Chow
BACKGROUND: Two-thirds of U.S. adult women are overweight or obese. High body mass index (BMI) and adult weight gain are risk factors for a number of chronic diseases, including postmenopausal breast cancer. The higher postmenopausal breast cancer risk in women with elevated BMI is likely to be attributable to related metabolic disturbances including altered circulating sex steroid hormones and adipokines, elevated pro-inflammatory cytokines, and insulin resistance. Metformin is a widely used antidiabetic drug that has demonstrated favorable effects on metabolic disturbances and as such may lead to lower breast cancer risk in obese women...
2016: BMC Cancer
Brian L Sprague, Emily F Conant, Tracy Onega, Michael P Garcia, Elisabeth F Beaber, Sally D Herschorn, Constance D Lehman, Anna N A Tosteson, Ronilda Lacson, Mitchell D Schnall, Despina Kontos, Jennifer S Haas, Donald L Weaver, William E Barlow
Background: About half of U.S. states currently have legislation requiring radiology facilities to disclose mammographic breast density information to women, often with language recommending discussion of supplemental screening options for women with dense breasts. Objective: To examine variation in breast density assessment across radiologists in clinical practice. Design: Cross-sectional and longitudinal analyses of prospectively collected observational data...
July 19, 2016: Annals of Internal Medicine
J Christopher Gallagher, Santiago Palacios, Kelly A Ryan, Ching-Ray Yu, Kaijie Pan, David L Kendler, Sebastian Mirkin, Barry S Komm
OBJECTIVE: Conjugated estrogens/bazedoxifene reduces vasomotor symptoms and prevents postmenopausal bone loss without stimulating the breast and endometrium. We analyzed changes in bone mineral density (BMD) and bone markers using pooled data from two phase-3 trials. METHODS: Selective Estrogens, Menopause, and Response to Therapy (SMART)-1 and SMART-5 were randomized, double-blind, placebo- and active-controlled studies conducted in postmenopausal nonhysterectomized women...
October 2016: Menopause: the Journal of the North American Menopause Society
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"