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https://www.readbyqxmd.com/read/28068940/early-life-socioeconomic-environment-and-mammographic-breast-density
#1
Parisa Tehranifar, Barbara A Cohn, Julie D Flom, Angeline Protacio, Piera Cirillo, L H Lumey, Karin B Michels, Mary Beth Terry
BACKGROUND: Early life social environment may influence breast cancer through shaping risk factors operating in early life, adolescence and adulthood, or may be associated with breast cancer risk independent of known risk factors. We investigated the associations between early life socioeconomic status (SES) and mammographic density, a strong risk factor for breast cancer, and the extent to which these associations were independent of risk factors across the lifecourse. METHODS: We used data from an adult follow-up study of two U...
January 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28062399/longitudinal-study-of-mammographic-density-measures-that-predict-breast-cancer-risk
#2
Kavitha Krishnan, Laura Baglietto, Jennifer Stone, Julie A Simpson, Gianluca Severi, Christopher Evans, Robert J MacInnis, Graham G Giles, Carmel Apicella, John L Hopper
BACKGROUND: After adjusting for age and body mass index (BMI), mammographic measures - dense area (DA), percent dense area (PDA) and non-dense area (NDA) - are associated with breast cancer risk. Our aim was to use longitudinal data to estimate the extent to which these risk-predicting measures track over time. METHODS: We collected 4,320 mammograms (age range, 24-83 years) from 970 women in the Melbourne Collaborative Cohort Study and the Australian Breast Cancer Family Registry...
January 6, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28040694/risk-factors-that-increase-risk-of-estrogen-receptor-positive-and-negative-breast-cancer
#3
Karla Kerlikowske, Charlotte C Gard, Jeffrey A Tice, Elad Ziv, Steven R Cummings, Diana L Miglioretti
BACKGROUND: Risk factors may differentially influence development of estrogen receptor (ER)-positive vs -negative breast cancer. We examined associations with strong, prevalent risk factors by ER subtype. METHODS: Of 1 279 443 women age 35 to 74 years participating in the Breast Cancer Surveillance Consortium, 14 969 developed ER-positive and 3617 developed ER-negative invasive breast cancer. We calculated hazard ratios (HRs) using Cox regression and compared ER subtype hazard ratios at representative ages or by menopausal status using Wald tests...
May 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28026901/the-effect-of-exercise-on-body-composition-and-bone-mineral-density-in-breast-cancer-survivors-taking-aromatase-inhibitors
#4
Gwendolyn A Thomas, Brenda Cartmel, Maura Harrigan, Martha Fiellin, Scott Capozza, Yang Zhou, Elizabeth Ercolano, Cary P Gross, Dawn Hershman, Jennifer Ligibel, Kathryn Schmitz, Fang-Yong Li, Tara Sanft, Melinda L Irwin
OBJECTIVE: This study examined the effect of 12 months of aerobic and resistance exercise versus usual care on changes in body composition in postmenopausal breast cancer survivors taking aromatase inhibitors (AIs). METHODS: The Hormones and Physical Exercise study enrolled 121 breast cancer survivors and randomized them to either supervised twice-weekly resistance exercise training and 150 min/wk of aerobic exercise (N = 61) or a usual care (N = 60) group. Dual-energy X-ray absorptiometry scans were conducted at baseline, 6 months, and 12 months to assess changes in body mass index, percent body fat, lean body mass, and bone mineral density...
December 27, 2016: Obesity
https://www.readbyqxmd.com/read/27986574/mammography-before-and-after-bariatric-surgery
#5
Tara E Mokhtari, Ulysses S Rosas, John R Downey, Kanae K Miyake, Debra M Ikeda, John M Morton
BACKGROUND: Morbidly obese women are at increased risk for breast cancer, and the majority of surgical weight-loss patients are older than 40 years old. OBJECTIVE: The purpose of the present study was to determine the technical and interpretive changes in mammography following bariatric surgery. SETTING: Accredited Academic Hospital. METHODS: Two breast-imaging radiologists reviewed screening mammograms performed on 10 morbidly obese women undergoing bariatric surgery both pre- and postoperatively...
October 31, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27940975/maternal-anthropometry-and-mammographic-density-in-adult-daughters
#6
Karin B Michels, Barbara A Cohn, Mandy Goldberg, Julie D Flom, Marcelle Dougan, Mary Beth Terry
OBJECTIVE: We examined the relation between maternal anthropometry and mammographic density in the adult daughter using prospectively collected data. METHODS: Our study included a total of 700 mother-daughter dyads participating in an adult follow-up of women born in 2 US birth cohorts: the Child Health and Development Study and the Boston, Massachusetts, and Providence, Rhode Island sites of the National Collaborative Perinatal Project. RESULTS: We observed an increased percent breast density at a mean age of 43...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27923387/mammographic-texture-and-risk-of-breast-cancer-by-tumor-type-and-estrogen-receptor-status
#7
Serghei Malkov, John A Shepherd, Christopher G Scott, Rulla M Tamimi, Lin Ma, Kimberly A Bertrand, Fergus Couch, Matthew R Jensen, Amir P Mahmoudzadeh, Bo Fan, Aaron Norman, Kathleen R Brandt, V Shane Pankratz, Celine M Vachon, Karla Kerlikowske
BACKGROUND: Several studies have shown that mammographic texture features are associated with breast cancer risk independent of the contribution of breast density. Thus, texture features may provide novel information for risk stratification. We examined the association of a set of established texture features with breast cancer risk by tumor type and estrogen receptor (ER) status, accounting for breast density. METHODS: This study combines five case-control studies including 1171 breast cancer cases and 1659 controls matched for age, date of mammogram, and study...
December 6, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27882030/association-between-25-hydroxy-vitamin-d-and-volumetric-breast-density-via-a-fully-automated-software-volpara%C3%A2-in-the-reproductive-age-group
#8
Bushra Wasim, Khalid Khan, Mohd Abdul Samad
OBJECTIVE: To determine the association between serum 25 hydroxyvitamin D levels and percent breast density among asymptomatic premenopausal women. METHODS: Hundred asymptomatic, pre-menopausal women who visited the General Surgery Breast Clinic, Patel Hospital, Karachi, Pakistan between 3rd March and 10th November, 2015 were included in this study. The serum 25 (OH)D and calcium levels were measured and mammographic density (MD) was assessed using automated volumetric breast density software, Volpara Research (algorithm version 1...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27873046/commercially-available-lifestyle-modification-program-randomized-controlled-trial-addressing-heart-and-bone-health-in-brca1-2-breast-cancer-survivors-after-risk-reducing-salpingo-oophorectomy
#9
Kathleen M Sturgeon, Lorraine T Dean, Mariane Heroux, Jessica Kane, Toni Bauer, Erica Palmer, Jin Long, Shannon Lynch, Linda Jacobs, David B Sarwer, Mary B Leonard, Kathryn Schmitz
PURPOSE: The goal of this RCT was to examine the efficacy and safety of a web-based program to improve cardiovascular and bone health outcomes, among 35 BRCA1/2+ breast cancer survivors who underwent prophylactic oophorectomy and thus experienced premature surgical menopause. METHODS: A 12-month commercially available web-based lifestyle modification program (Precision Nutrition Coaching) was utilized. Cardiovascular fitness, dietary intake, leisure time activity, body composition, bone mineral density, bone structure, and muscle strength were assessed...
November 21, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27864712/associations-between-serum-lipids-and-breast-cancer-incidence-and-survival-in-the-e3n-prospective-cohort-study
#10
Mathilde His, Laureen Dartois, Guy Fagherazzi, Anne Boutten, Thierry Dupré, Sylvie Mesrine, Marie-Christine Boutron-Ruault, Françoise Clavel-Chapelon, Laure Dossus
PURPOSE: Several mechanistic studies support a role of cholesterol or its metabolites in breast cancer etiology, but associations have been inconsistent in epidemiological studies. In observational studies, possible reverse causation must be accounted for using a prospective design. We investigated prospective associations between pre-diagnostic serum lipid concentrations [total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides], and both breast cancer risk and survival in the E3N cohort study...
January 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27864652/differences-in-mammographic-density-between-asian-and-caucasian-populations-a-comparative-analysis
#11
Nadia Rajaram, Shivaani Mariapun, Mikael Eriksson, Jose Tapia, Pui Yoke Kwan, Weang Kee Ho, Faizah Harun, Kartini Rahmat, Kamila Czene, Nur Aishah Mohd Taib, Per Hall, Soo Hwang Teo
PURPOSE: Mammographic density is a measurable and modifiable biomarker that is strongly and independently associated with breast cancer risk. Paradoxically, although Asian women have lower risk of breast cancer, studies of minority Asian women in predominantly Caucasian populations have found that Asian women have higher percent density. In this cross-sectional study, we compared the distribution of mammographic density for a matched cohort of Asian women from Malaysia and Caucasian women from Sweden, and determined if variations in mammographic density could be attributed to population differences in breast cancer risk factors...
November 18, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27832519/automatic-estimation-of-volumetric-breast-density-using-artificial-neural-network-based-calibration-of-full-field-digital-mammography-feasibility-on-japanese-women-with-and-without-breast-cancer
#12
Jeff Wang, Fumi Kato, Hiroko Yamashita, Motoi Baba, Yi Cui, Ruijiang Li, Noriko Oyama-Manabe, Hiroki Shirato
Breast cancer is the most common invasive cancer among women and its incidence is increasing. Risk assessment is valuable and recent methods are incorporating novel biomarkers such as mammographic density. Artificial neural networks (ANN) are adaptive algorithms capable of performing pattern-to-pattern learning and are well suited for medical applications. They are potentially useful for calibrating full-field digital mammography (FFDM) for quantitative analysis. This study uses ANN modeling to estimate volumetric breast density (VBD) from FFDM on Japanese women with and without breast cancer...
November 10, 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/27832382/diabetes-diabetes-treatment-and-mammographic-density-in-danish-diet-cancer-and-health-cohort
#13
Karsten Buschard, Katrin Thomassen, Elsebeth Lynge, Ilse Vejborg, Anne Tjønneland, My von Euler-Chelpin, Zorana Jovanovic Andersen
PURPOSE: We examined whether diabetes and diabetes treatment are associated with MD in a cohort study of Danish women above age of 50 years. METHODS: Study cohort consisted of 5,644 women (4,500 postmenopausal) who participated in the Danish Diet, Cancer, and Health cohort (1993-1997) and subsequently attended mammographic screening in Copenhagen (1993-2001). We used MD assessed at the first screening after the cohort entry, defined as mixed/dense or fatty. Diabetes diagnoses and diabetes treatments (diet, insulin, or oral antidiabetic agents) were self-reported at the time of recruitment (1993-1997)...
January 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27806604/breast-parenchymal-patterns-in-processed-versus-raw-digital-mammograms-a-large-population-study-toward-assessing-differences-in-quantitative-measures-across-image-representations
#14
Aimilia Gastounioti, Andrew Oustimov, Brad M Keller, Lauren Pantalone, Meng-Kang Hsieh, Emily F Conant, Despina Kontos
PURPOSE: With raw digital mammograms (DMs), which retain the relationship with x-ray attenuation of the breast tissue, not being routinely available, processed DMs are often the only viable means to acquire imaging measures. The authors investigate differences in quantitative measures of breast density and parenchymal texture, shown to have value in breast cancer risk assessment, between the two DM representations. METHODS: The authors report data from 8458 pairs of bilateral raw ("FOR PROCESSING") and processed ("FOR PRESENTATION") DMs acquired from 4278 women undergoing routine screening evaluation, collected with DM units from two different vendors...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27799412/the-effect-of-california-s-breast-density-notification-legislation-on-breast-cancer-screening
#15
Stephanie Lynn Chau, Amy Alabaster, Karin Luikart, Leslie Manace Brenman, Laurel A Habel
PURPOSE: Half of US states mandate women be notified if they have dense breasts on their mammogram, yet guidelines and data on supplemental screening modalities are limited. Breast density (BD) refers to the extent that breast tissue appears radiographically dense on mammograms. High BD reduces the sensitivity of screening mammography and increases breast cancer risk. The aim of this study was to determine the potential impact of California's 2013 BD notification legislation on breast cancer screening patterns...
October 31, 2016: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/27793125/living-well-after-breast-cancer-randomized-controlled-trial-protocol-evaluating-a-telephone-delivered-weight-loss-intervention-versus-usual-care-in-women-following-treatment-for-breast-cancer
#16
Marina M Reeves, Caroline O Terranova, Jane M Erickson, Jennifer R Job, Denise S K Brookes, Nicole McCarthy, Ingrid J Hickman, Sheleigh P Lawler, Brianna S Fjeldsoe, Genevieve N Healy, Elisabeth A H Winkler, Monika Janda, J Lennert Veerman, Robert S Ware, Johannes B Prins, Theo Vos, Wendy Demark-Wahnefried, Elizabeth G Eakin
BACKGROUND: Obesity, physical inactivity and poor diet quality have been associated with increased risk of breast cancer-specific and all-cause mortality as well as treatment-related side-effects in breast cancer survivors. Weight loss intervention trials in breast cancer survivors have shown that weight loss is safe and achievable; however, few studies have examined the benefits of such interventions on a broad range of outcomes and few have examined factors important to translation (e...
October 28, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27783370/the-short-term-effect-of-weight-loss-surgery-on-volumetric-breast-density-and-fibroglandular-volume
#17
Nasreen A Vohra, Swapnil D Kachare, Paul Vos, Bruce F Schroeder, Olga Schuth, Dylan Suttle, Timothy L Fitzgerald, Jan H Wong, Kathryn M Verbanac
PURPOSE: Obesity and breast density are both associated with an increased risk of breast cancer and are potentially modifiable. Weight loss surgery (WLS) causes a significant reduction in the amount of body fat and a decrease in breast cancer risk. The effect of WLS on breast density and its components has not been documented. Here, we analyze the impact of WLS on volumetric breast density (VBD) and on each of its components (fibroglandular volume and breast volume) by using three-dimensional methods...
October 26, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27729066/pre-natal-exposures-and-breast-tissue-composition-findings-from-a-british-pre-birth-cohort-of-young-women-and-a-systematic-review
#18
Rachel Denholm, Bianca De Stavola, John H Hipwell, Simon J Doran, Marta C Busana, Amanda Eng, Mona Jeffreys, Martin O Leach, David Hawkes, Isabel Dos Santos Silva
BACKGROUND: Breast density, the amount of fibroglandular tissue in the adult breast for a women's age and body mass index, is a strong biomarker of susceptibility to breast cancer, which may, like breast cancer risk itself, be influenced by events early in life. In the present study, we investigated the association between pre-natal exposures and breast tissue composition. METHODS: A sample of 500 young, nulliparous women (aged approximately 21 years) from a U...
October 12, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27717337/polymorphisms-in-the-estrogen-receptor-alpha-gene-esr1-daily-cycling-estrogen-and-mammographic-density-phenotypes
#19
F N Fjeldheim, H Frydenberg, V G Flote, A McTiernan, A-S Furberg, P T Ellison, E S Barrett, T Wilsgaard, G Jasienska, G Ursin, E A Wist, I Thune
BACKGROUND: Single nucleotide polymorphisms (SNPs) involved in the estrogen pathway and SNPs in the estrogen receptor alpha gene (ESR1 6q25) have been linked to breast cancer development, and mammographic density is an established breast cancer risk factor. Whether there is an association between daily estradiol levels, SNPs in ESR1 and premenopausal mammographic density phenotypes is unknown. METHODS: We assessed estradiol in daily saliva samples throughout an entire menstrual cycle in 202 healthy premenopausal women in the Norwegian Energy Balance and Breast Cancer Aspects I study...
October 7, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27716311/novel-mammographic-image-features-differentiate-between-interval-and-screen-detected-breast-cancer-a-case-case-study
#20
Fredrik Strand, Keith Humphreys, Abbas Cheddad, Sven Törnberg, Edward Azavedo, John Shepherd, Per Hall, Kamila Czene
BACKGROUND: Interval breast cancers are often diagnosed at a more advanced stage than screen-detected cancers. Our aim was to identify features in screening mammograms of the normal breast that would differentiate between future interval cancers and screen-detected cancers, and to understand how each feature affects tumor detectability. METHODS: From a population-based cohort of invasive breast cancer cases in Stockholm-Gotland, Sweden, diagnosed from 2001 to 2008, we analyzed the contralateral mammogram at the preceding negative screening of 394 interval cancer cases and 1009 screen-detected cancers...
October 5, 2016: Breast Cancer Research: BCR
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