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https://www.readbyqxmd.com/read/29144164/correlation-between-obesity-and-fat-infiltrated-axillary-lymph-nodes-visualized-on-mammography
#1
Roberta Maria M diFlorio Alexander, Steffen J Haider, Todd MacKenzie, Martha E Goodrich, Julie Weiss, Tracy Onega
OBJECTIVE: Using screening mammography, this study investigated the association between obesity and axillary lymph node (LN) size and morphology. METHODS: We conducted a retrospective review of 188 women who underwent screening mammography at an academic medical center. Length and width of the LN and hilum were measured in the largest, mammographically visible axillary node. The hilo-cortical ratio (HCR) was calculated as the hilar width divided by the cortical width...
November 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29139618/beyond-sarcopenia-characterization-and-integration-of-skeletal-muscle-quantity-and-radiodensity-in-a-curable-breast-cancer-population
#2
Marc S Weinberg, Shlomit S Shachar, Hyman B Muss, Allison M Deal, Karteek Popuri, Hyeon Yu, Kirsten A Nyrop, Shani M Alston, Grant R Williams
Skeletal muscle loss, commonly known as sarcopenia, is highly prevalent and prognostic of adverse outcomes in oncology. However, there is limited information on adults with early breast cancer and examination of other skeletal muscle indices, despite the potential prognostic importance. This study characterizes and examines age-related changes in body composition of adults with early breast cancer and describes the creation of a novel integrated muscle measure. Female patients diagnosed with stage I-III breast cancer with abdominal computerized tomography (CT) scans within 12 weeks from diagnosis were identified from local tumor registry (N = 241)...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29098437/breast-compression-parameters-and-mammographic-density-in-the-norwegian-breast-cancer-screening-programme
#3
Nataliia Moshina, Marta Roman, Gunvor G Waade, Sofie Sebuødegård, Giske Ursin, Solveig Hofvind
OBJECTIVES: To investigate possible associations between breast compression parameters, including compression force, pressure and compressed breast thickness, and mammographic density assessed by an automated software. METHODS: We obtained data on breast compression parameters, breast volume, absolute and percentage dense volume, and body mass index for 14,698 women screened with two-view (craniocaudal, CC, and mediolateral oblique, MLO) digital mammography, in the Norwegian Breast Cancer Screening Programme, 2014-2015...
November 2, 2017: European Radiology
https://www.readbyqxmd.com/read/29074552/occupational-exposures-and-mammographic-density-in-spanish-women
#4
Virginia Lope, Javier García-Pérez, Beatriz Pérez-Gómez, Ana María Pedraza-Flechas, Juan Alguacil, Mª Carmen González-Galarzo, Miguel Angel Alba, Rudolf van der Haar, Rosa Ana Cortés-Barragán, Carmen Pedraz-Pingarrón, Pilar Moreo, Carmen Santamariña, María Ederra, Carmen Vidal, Dolores Salas-Trejo, Carmen Sánchez-Contador, Rafael Llobet, Marina Pollán
OBJECTIVES: The association between occupational exposures and mammographic density (MD), a marker of breast cancer risk, has not been previously explored. Our objective was to investigate the influence of occupational exposure to chemical, physical and microbiological agents on MD in adult women. METHODS: This is a population-based cross-sectional study based on 1476 female workers aged 45-65 years from seven Spanish breast cancer screening programmes. Occupational history was surveyed by trained staff...
October 26, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29063662/breast-density-in-multiethnic-women-presenting-for-screening-mammography
#5
Bridget A Oppong, Chiranjeev Dash, Suzanne O'Neill, Yinan Li, Kepher Makambi, Edward Pien, Erini Makariou, Tesha Coleman, Lucile L Adams-Campbell
Data on ethnic variations in breast density are limited and often not inclusive of underrepresented minorities. As breast density is associated with elevated breast cancer risk, investigating racial and ethnic difference may elucidate the observed differences in breast cancer risk among different populations. We reviewed breast density from initial screening of women from the Capital Breast Care Center and Georgetown University Hospital from 2010 to 2014. Patient demographics including race, age at screening, education, menopausal status, and body mass index were abstracted...
October 24, 2017: Breast Journal
https://www.readbyqxmd.com/read/29040039/breast-cancer-risk-associations-with-digital-mammographic-density-by-pixel-brightness-threshold-and-mammographic-system
#6
Tuong L Nguyen, Yoon-Ho Choi, Ye K Aung, Christopher F Evans, Nhut H Trinh, Shuai Li, Gillian S Dite, Myeong-Seong Kim, Patrick C Brennan, Mark A Jenkins, Joohon Sung, Yun-Mi Song, John L Hopper
Purpose To compare three mammographic density measures defined by different pixel intensity thresholds as predictors of breast cancer risk for two different digital mammographic systems. Materials and Methods The Korean Breast Cancer Study included 398 women with invasive breast cancer and 737 control participants matched for age at mammography (±1 year), examination date, mammographic system, and menopausal status. Mammographic density was measured by using the automated Laboratory for Individualized Breast Radiodensity Assessment (LIBRA) software and the semiautomated Cumulus software at the conventional threshold (Cumulus) and at increasingly higher thresholds (Altocumulus and Cirrocumulus, respectively)...
October 16, 2017: Radiology
https://www.readbyqxmd.com/read/28957821/association-between-mammographic-density-and-tumor-marker-defined-breast-cancer-subtypes-a-case-control-study
#7
Jinyoung Shin, Jeong Eon Lee, Hyeon Young Ko, Tuong Linh Nguyen, Seok Jin Nam, John Llewelyn Hopper, Yun-Mi Song
High mammographic density (MD) is the most important risk factor for breast cancer. This study aimed to clarify the relationship between MD and breast cancer subtypes defined by tumor markers. We enrolled 642 women with breast cancer (69% premenopausal) and 1241 controls matched for age and menopausal status. Absolute mammographic dense area (ADA), percent mammographic dense area (PDA), and nondense area were assessed using a computer-assisted thresholding technique. We classified breast cancer cases into four subtypes using information on tumor marker expression such as estrogen receptor (ER), progesterone receptor (PR), and Cerb2 receptor (HER2); luminal A (ER+ and/or PR+, HER2-), luminal B (ER+ and/or PR+, HER2+), HER2-overexpressing (ER-, PR-, and HER2+), and triple-negative (ER-, PR-, and HER2-)...
September 27, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28952021/mammographic-appearances-in-mongolia-causal-factors-for-varying-densities
#8
D Demchig, C Mello-Thoms, Kh Khulan, A Ramish, P C Brennan
Objective: Mammographic density (MD) is a significant risk factor for breast cancer and an important determinant for establishing efficiency of any screening program. Currently, the distribution and influential factors of MD is unknown among Mongolian women. This work aims to characterize MD of Mongolian women. Methods: The ethical approval was obtained from Research Ethics Board of the University of Sydney (2014/973) and National Ethic Committee from Ministry of Mongolia (2015/04). We recruited 1985 women aged 16-83 from the National Cancer Center in Mongolia for whom MD and age of each woman was known...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28904061/a-randomized-controlled-trial-of-green-tea-extract-supplementation-and-mammographic-density-in-postmenopausal-women-at-increased-risk-of-breast-cancer
#9
Hamed Samavat, Giske Ursin, Tim H Emory, Eunjung Lee, Renwei Wang, Carolyn J Torkelson, Allison M Dostal, Karen Swenson, Chap T Le, Chung S Yang, Mimi C Yu, Douglas Yee, Anna H Wu, Jian-Min Yuan, Mindy S Kurzer
Epidemiological and animal studies suggest a protective role of green tea against breast cancer. However the underlying mechanism is not understood. We conducted a randomized, double-blinded, placebo-controlled phase II clinical trial to investigate whether supplementation with green tea extract (GTE) modifies mammographic density (MD), as a potential mechanism, involving 1,075 healthy postmenopausal women. Women assigned to the treatment arm consumed daily 4 decaffeinated GTE capsules containing 1315 mg total catechins including 843 mg epigallocatechin-3-gallate (EGCG) for 12 months...
September 13, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28843166/occupation-and-mammographic-density-a-population-based-study-ddm-occup
#10
MULTICENTER STUDY
Javier García-Pérez, Marina Pollán, Beatriz Pérez-Gómez, Mario González-Sánchez, Rosa Ana Cortés Barragán, Jerónimo Maqueda Blasco, María Carmen González-Galarzo, Miguel Ángel Alba, Rudolf van der Haar, Silvia Casas, Cándida Vicente, Pilar Medina, María Ederra, Carmen Santamariña, María Pilar Moreno, Francisco Casanova, Carmen Pedraz-Pingarrón, Pilar Moreo, Nieves Ascunce, Montse García, Dolores Salas-Trejo, Carmen Sánchez-Contador, Rafael Llobet, Virginia Lope
INTRODUCTION: High mammographic density is one of the main risk factors for breast cancer. Although several occupations have been associated with breast cancer, there are no previous occupational studies exploring the association with mammographic density. Our objective was to identify occupations associated with high mammographic density in Spanish female workers. METHODS: We conducted a population-based cross-sectional study of occupational determinants of high mammographic density in Spain, based on 1476 women, aged 45-68 years, recruited from seven screening centers within the Spanish Breast Cancer Screening Program network...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28830497/combining-quantitative-and-qualitative-breast-density-measures-to-assess-breast-cancer-risk
#11
Karla Kerlikowske, Lin Ma, Christopher G Scott, Amir P Mahmoudzadeh, Matthew R Jensen, Brian L Sprague, Louise M Henderson, V Shane Pankratz, Steven R Cummings, Diana L Miglioretti, Celine M Vachon, John A Shepherd
BACKGROUND: Accurately identifying women with dense breasts (Breast Imaging Reporting and Data System [BI-RADS] heterogeneously or extremely dense) who are at high breast cancer risk will facilitate discussions of supplemental imaging and primary prevention. We examined the independent contribution of dense breast volume and BI-RADS breast density to predict invasive breast cancer and whether dense breast volume combined with Breast Cancer Surveillance Consortium (BCSC) risk model factors (age, race/ethnicity, family history of breast cancer, history of breast biopsy, and BI-RADS breast density) improves identifying women with dense breasts at high breast cancer risk...
August 22, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28828694/association-between-mammographic-density-and-pregnancies-relative-to-age-and-bmi-a-breast-cancer-case-only-analysis
#12
Carolin C Hack, Julius Emons, Sebastian M Jud, Katharina Heusinger, Werner Adler, Paul Gass, Lothar Haeberle, Felix Heindl, Alexander Hein, Rüdiger Schulz-Wendtland, Michael Uder, Arndt Hartmann, Matthias W Beckmann, Peter A Fasching, Uwe G Pöhls
PURPOSE: Percentage mammographic density (PMD) is a major risk factor for breast cancer (BC). It is strongly associated with body mass index (BMI) and age, which are themselves risk factors for breast cancer. This analysis investigated the association between the number of full-term pregnancies and PMD in different subgroups relative to age and BMI. METHODS: Patients were identified in the breast cancer database of the University Breast Center for Franconia. A total of 2410 patients were identified, for whom information on parity, age, and BMI, and a mammogram from the time of first diagnosis were available for assessing PMD...
August 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28767986/mammographic-density-among-indigenous-women-in-forested-areas-in-the-state-of-amap%C3%A3-brazil-a-cross-sectional-study
#13
José Mauro Secco, Simone Elias, Cristina Valletta de Carvalho, Ismael Dale Cotrim Guerreiro da Silva, Kátia Jung de Campos, Gil Facina, Afonso Celso Pinto Nazário
CONTEXT AND OBJECTIVE: There is no register of breast cancer cases among indigenous populations in Brazil. The objective here was to evaluate the association of clinical and demographic characteristics with mammographic density among indigenous women. DESIGN AND SETTING: Cross-sectional analytical study conducted in indigenous territories in the state of Amapá, Brazil. METHODS: Women were recruited from three indigenous territories and underwent bilateral mammography and blood collection for hormonal analysis...
July 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28746163/the-potential-contribution-of-dietary-factors-to-breast-cancer-prevention
#14
Niva Shapira
Breast cancer (BC), the leading cancer in women, is increasing in prevalence worldwide, concurrent with western metabolic epidemics, that is, obesity, metabolic syndrome, and diabetes, and shares major risk factors with these diseases. The corresponding potential for nutritional contributions toward BC prevention is reviewed and related to critical stages in the life cycle and their implications for carcinogenic and pathometabolic trajectories. BC initiation potentially involves diet-related pro-oxidative, inflammatory, and procarcinogenic processes, that interact through combined lipid/fatty acid peroxidation, estrogen metabolism, and related DNA-adduct/depurination/mutation formation...
September 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28732505/body-size-in-early-life-and-risk-of-breast-cancer
#15
Md Shajedur Rahman Shawon, Mikael Eriksson, Jingmei Li
BACKGROUND: Body size in early life is inversely associated with adult breast cancer (BC) risk, but it is unclear whether the associations differ by tumor characteristics. METHODS: In a pooled analysis of two Swedish population-based studies consisting of 6731 invasive BC cases and 28,705 age-matched cancer-free controls, we examined the associations between body size in early life and BC risk. Self-reported body sizes at ages 7 and 18 years were collected by a validated nine-level pictogram (aggregated into three categories: small, medium and large)...
July 21, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28719794/associations-of-breast-density-with-demographic-reproductive-and-lifestyle-factors-in-a-developing-southeast-asian-population
#16
Phuong Dung Yun Trieu, Claudia Mello-Thoms, Jennifer K Peat, Thuan Doan Do, Patrick C Brennan
The aim of this study was to investigate how breast density interacted with demographic, reproductive, and lifestyle features among Vietnamese women. Mammographic density and established risk factors for breast cancer were collected from 1651 women (345 cancer cases and 1306 normal cases) in Vietnam. The association of breast density categories with potential risk factors was investigated using Spearman's test for continuous variables and χ(2) tests for categorical variables. Independent factors associated with high breast density and breast cancer in specific density groupings were assessed using logistic regression...
July 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28708471/use-of-bisphosphonates-and-risk-of-breast-cancer-in-a-french-cohort-of-postmenopausal-women
#17
Agnès Fournier, Sylvie Mesrine, Amandine Gelot, Guy Fagherazzi, Laura Baglietto, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Nathalie Chabbert-Buffet
Purpose To assess whether bisphosphonate (BP) use is associated with decreased breast cancer incidence in a cohort of postmenopausal women. Methods The study population included 64,438 postmenopausal women participating in the French E3N (Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale) prospective cohort, with data self-reported in biennial questionnaires matched with data from a drug reimbursement database. Exposure to BPs and the use of other osteoporosis treatments during follow-up were determined using reimbursement data...
October 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28702890/adiposity-during-early-adulthood-changes-in-adiposity-during-adulthood-attained-adiposity-and-mammographic-density-among-premenopausal-women
#18
Aliya Alimujiang, Catherine Appleton, Graham A Colditz, Adetunji T Toriola
PURPOSE: We investigated the associations of adolescent adiposity, changes in adiposity during adulthood, and attained adiposity with volumetric mammographic density measures. METHODS: We recruited 383 premenopausal women who had a routine screening mammogram at the Breast Health Center, Washington University in St. Louis, MO from December 2015 to October 2016. Trained research personnel assessed current adiposity measures. Weight at ages 18 and 30 were self-reported...
July 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28701570/adipose-derived-fatty-acid-binding-proteins-plasma-concentrations-are-increased-in-breast-cancer-patients
#19
Sandra Guaita-Esteruelas, Paula Saavedra-García, Alba Bosquet, Joan Borràs, Josefa Girona, Kepa Amiliano, Marta Rodríguez-Balada, Mercedes Heras, Luís Masana, Josep Gumà
BACKGROUND: Adipose tissue is an endocrine organ that could play a role in tumor progression via its secreted adipokines. The role of adipose-derived fatty acid-binding protein (FABP) 4 and FABP5 in breast cancer is presently under study, but their circulating levels in this pathology are poorly known. We analyzed the blood concentrations of FABP4 and FABP5 in breast cancer patients to determine whether there is an association between them and breast cancer. MATERIALS AND METHODS: We studied 294 women in the oncology department with a family history of breast cancer; 198 of the women had breast cancer, and 96 were healthy controls...
November 2017: Oncologist
https://www.readbyqxmd.com/read/28698185/age-at-menarche-and-late-adolescent-adiposity-associated-with-mammographic-density-on-processed-digital-mammograms-in-24-840-women
#20
Stacey E Alexeeff, Nnaemeka U Odo, Jafi A Lipson, Ninah Achacoso, Joseph H Rothstein, Martin J Yaffe, Rhea Y Liang, Luana Acton, Valerie McGuire, Alice S Whittemore, Daniel L Rubin, Weiva Sieh, Laurel A Habel
Background: High mammographic density is strongly associated with increased breast cancer risk. Some, but not all, risk factors for breast cancer are also associated with higher mammographic density.Methods: The study cohort (N = 24,840) was drawn from the Research Program in Genes, Environment and Health of Kaiser Permanente Northern California and included non-Hispanic white females ages 40 to 74 years with a full-field digital mammogram (FFDM). Percent density (PD) and dense area (DA) were measured by a radiological technologist using Cumulus...
September 2017: Cancer Epidemiology, Biomarkers & Prevention
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