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https://www.readbyqxmd.com/read/27546538/the-role-of-mir-146a-on-nf-%C3%AE%C2%BAb-expression-level-in-human-umbilical-vein-endothelial-cells-under-hyperglycemic-condition
#1
K Kamali, E Salmani Korjan, E Eftekhar, K Malekzadeh, F Ghadiri Soufi
Emerging studies have been shown that the expression of micrRNA-146a (miR-146a, as a regulator of nuclear factor κB (NF-κB)), is changed in diabetic patients and animals. This study was designed to evaluate the possible role of miR-146a in the pathogenesis of diabetes-related microvascular complications. Concurrent with the creation of cellular hyperglycemia (25 mmol/L for 24 h), human umbilical vein endothelial cells (HUVECs) were transfected with 20 nmol/L of hsa-miR-146a antagomir or scramble using HiPerFect reagent (Qiagen)...
2016: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/24957404/microrna-199a-3p-and-microrna-34a-regulate-apoptosis-in-human-osteosarcoma-cells
#2
Ye Tian, Ying-Ze Zhang, Wei Chen
miRNAs (microRNAs) are small non-coding RNAs [18-25 nt (nucleotides)] that regulate gene expression mainly through affecting post-transcriptional modification. Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. miRNAs play an important role in cancer cell growth and migration; however, the potential roles of miRNAs in osteosarcoma remain largely uncharacterized. In this paper, miR-199a and miR-34a were discussed the mechanisms of apoptosis using miRNA mimics in human osteosarcoma cells...
2014: Bioscience Reports
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