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Pediatric Gastroesophageal reflux

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https://www.readbyqxmd.com/read/27920480/comparison-of-multichannel-intraluminal-impedance-ph-monitoring-and-reflux-scintigraphy-in-pediatric-patients-with-suspected-gastroesophageal-reflux
#1
Nuray Uslu Kızılkan, Murat Fani Bozkurt, Inci Nur Saltık Temizel, Hülya Demir, Aysel Yüce, Biray Caner, Hasan Özen
AIM: To evaluate the agreement of multichannel intraluminal impedance-pH monitoring (MII-pHM) and gastroesophageal reflux scintigraphy (GES) for the diagnosis of gastroesophageal reflux disease. METHODS: Seventy-five consecutive patients with suspected gastroesophageal reflux disease (GERD) underwent 24-h combined MII-pHM recording and one hour radionuclide scintigraphy during the course of the MII-pHM study. Catheters with 6 impedance channels and 1 pH sensor were placed transnasally...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27875488/esomeprazole-fda-approval-in-children-with-gerd-exposure-matching-and-exposure-response
#2
Justin C Earp, Nitin Mehrotra, Kristina E Peters, Robert P Fiorentino, Donna Griebel, Sue Chih Lee, Andrew Mulberg, Kerstin Röhss, Marie Sandström, Amy Taylor, Christoffer W Tornøe, Erica L Wynn, Jan-Stefan Van der Walt, Christine Garnett
OBJECTIVES: FDA approval of proton-pump inhibitors for infantile GERD has been limited by intra-patient variability in the clinical assessment of GERD. For children 1-17 years old, extrapolating efficacy from adults for IV esomeprazole was accepted. The oral formulation was previously approved in children. Exposure-response and exposure matching analyses were sought to identify approvable pediatric doses. METHODS: Intragastric pH biomarker comparisons between children and adults were conducted...
November 19, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27868292/patterns-of-reflux-in-gastroesophageal-reflux-disease-in-pediatric-population-of-new-south-wales
#3
Sarath Kumar Narayanan, Ralph Clinton Cohen, Jonathan Saul Karpelowsky
This study is to determine the association of ambulatory pH monitoring (24hr pH) with symptoms of gastroesophageal reflux and its other investigations. The clinical and epidemiological profiles of subjects referred for reflux disorders are also studied. Symptoms or group of symptoms, profiles and prior investigations of 1259 consecutive pediatric subjects (with 1332 24hr pH studies performed) referred for evaluation of reflux disorders between 1988 and 2012 were retrospectively studied. Chi-square or fisher exact test was used for hypothesis testing, student t-test for the comparison of means and the Wilcoxon rank-sum test for comparing medians of continuous variables...
November 21, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27864715/laparoscopic-antireflux-surgery-increases-health-related-quality-of-life-in-children-with-gerd
#4
Femke A Mauritz, Rebecca K Stellato, L W Ernst van Heurn, Peter D Siersema, Cornelius E J Sloots, Roderick H J Houwen, David C van der Zee, Maud Y A van Herwaarden-Lindeboom
INTRODUCTION: Improving health-related quality of life (HRQoL) is increasingly recognized as an essential part of patient care outcome. Little is known about the effect of laparoscopic antireflux surgery (LARS) on the HRQoL in the pediatric patients. The aims of this study were to evaluate the effect of LARS on HRQoL in children with gastroesophageal reflux disease (GERD) and to identify predictors that influence HRQoL outcome after LARS. METHODS: Between 2011 and 2013, 25 patients with therapy-resistant GERD [median age 6 (2-18) years] were included prospectively...
November 18, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27824638/autism-spectrum-disorder-and-avoidant-restrictive-food-intake-disorder
#5
Jennifer Lucarelli, Demetra Pappas, Leah Welchons, Marilyn Augustyn
Kendra is a 4-year-old girl with autism spectrum disorder (ASD) who presents for follow-up of feeding problems to her pediatric clinician. She is an only child in a family where both parents are scientists. Feeding concerns date to infancy, when she was diagnosed with Gastroesophageal Reflux Disease (GERD) associated with persistent bottle refusal and the acceptance of few pureed foods. At 13 months, milk and peanut allergies were diagnosed. Following a feeding clinic evaluation at 24 months, she was prescribed a soy milk supplement and an H2 blocker...
November 4, 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27823773/surgical-management-of-gastroesophageal-reflux-disease-gerd-in-children-a-systematic-review
#6
Tim Jancelewicz, Monica E Lopez, Cynthia D Downard, Saleem Islam, Robert Baird, Shawn J Rangel, Regan F Williams, Meghan A Arnold, Dave Lal, Elizabeth Renaud, Julia Grabowski, Roshni Dasgupta, Mary Austin, Julia Shelton, Danielle Cameron, Adam B Goldin
OBJECTIVE: The goal of this systematic review by the American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee was to derive recommendations from the medical literature regarding the surgical treatment of pediatric gastroesophageal reflux disease (GERD). METHODS: Five questions were addressed by searching the MEDLINE, Cochrane, Embase, Central, and National Guideline Clearinghouse databases using relevant search terms. Consensus recommendations were derived for each question based on the best available evidence...
October 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27792528/two-stage-thoracoscopic-repair-of-long-gap-esophageal-atresia-using-internal-traction-is-safe-and-feasible
#7
Takahisa Tainaka, Hiroo Uchida, Akihide Tanano, Chiyoe Shirota, Akinari Hinoki, Naruhiko Murase, Kazuki Yokota, Kazuo Oshima, Ryo Shirotsuki, Kosuke Chiba, Hizuru Amano, Hiroshi Kawashima, Yujiro Tanaka
BACKGROUND: The treatment of long-gap esophageal atresia remains an issue for pediatric surgeons. Many techniques for treating long-gap esophageal atresia have been proposed, but the optimal method has not been established. The thoracoscopic esophageal elongation technique has recently been developed. We previously reported a case in which two-stage thoracoscopic repair was performed using internal esophageal traction without esophageal tearing, and we retrospectively reviewed the outcomes of this procedure in this study...
October 28, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27671545/alginate-therapy-is-effective-treatment-for-gastroesophageal-reflux-disease-symptoms-a-systematic-review-and-meta-analysis
#8
D A Leiman, B P Riff, S Morgan, D C Metz, G W Falk, B French, C A Umscheid, J D Lewis
In patients with gastroesophageal reflux disease (GERD) and erosive esophagitis, treatment with proton pump inhibitors (PPIs) is highly effective. However, in some patients, especially those with non-erosive reflux disease or atypical GERD symptoms, acid suppressive therapy with PPIs is not as successful. Alginates are medications that work through an alternative mechanism by displacing the post-prandial gastric acid pocket. We performed a systematic review and meta-analysis to examine the benefit of alginate-containing compounds in the treatment of patients with symptoms of GERD...
September 26, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27642394/pediatric-recurrent-respiratory-tract-infections-when-and-how-to-explore-the-immune-system-about-53-cases
#9
Mohammed El-Azami-El-Idrissi, Mounia Lakhdar-Idrissi, Sanae Chaouki, Samir Atmani, Abdelhak Bouharrou, Moustapha Hida
Recurrent respiratory tract infections are one of the most frequent reasons for pediatric visits and hospitalization. Causes of this pathology are multiple ranging from congenital to acquired and local to general. Immune deficiencies are considered as underlying conditions predisposing to this pathology. Our work is about to determine when and how to explore the immune system when facing recurrent respiratory infections. This was based on the records of 53 children hospitalized at the pediatrics unit of Hassan II University Hospital, Fez Morocco...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27521711/gastroesophageal-reflux-disease-in-children
#10
Douglas C Barnhart
Despite the frequency with which antireflux procedures are performed, decisions about gastroesophageal reflux disease treatment remain challenging. Several factors contribute to the difficulties in managing gastroesophageal reflux. First, the distinction between physiologic and pathologic gastroesophageal reflux (gastroesophageal reflux disease-GERD) is not always clear. Second, measures of the extent of gastroesophageal reflux often poorly correlate to symptoms or other complications attributed to reflux in infants and children...
August 2016: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/27457769/prevalence-of-overlap-syndromes-and-symptoms-in-pediatric-functional-dyspepsia
#11
Craig A Friesen, John M Rosen, Jennifer V Schurman
BACKGROUND: The purpose was to evaluate the overlap frequency of irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and overactive bladder syndrome (OBS), as well as other gastrointestinal and systemic symptoms, in functional dyspepsia (FD). Additionally, we sought to determine whether adult Rome III FD subtypes were uniquely related to overlap syndromes or symptoms. METHODS: The study was a retrospective review of 100 consecutive pediatric patients, age 8-17 years, diagnosed with FD...
2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27438415/combined-24-hours-esophageal-ph-monitoring-and-multichannel-intraluminal-impedance-for-comparison-of-gastroesophageal-reflux-in-children-with-typical-versus-atypical-symptoms-of-gastroesophageal-reflux-disease
#12
Seyed Mohsen Dehghani, Seyed Alireza Taghavi, Hazhir Javaherizadeh, Maryam Nasri
BACKGROUND: - Gastroesophageal reflux disease is the most common esophageal disorder in pediatrics. OBJECTIVE: - The aim of this study was to compare reflux parameters of typical and atypical symptoms of gastroesophageal reflux disease using 24-hour esophageal pH monitoring and multichannel intraluminal impedance in pediatric population. METHODS: - In this prospective study, 43 patients aged less than 18 year with suspected gastroesophageal reflux disease were enrolled...
July 2016: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/27412739/-clinical-analysis-of-enteral-nutrition-in-47-children
#13
R D Zhuang, L J Tang, Y H Fang, K R Peng, J Chen
OBJECTIVE: To explore the efficacy and safety of the application of enteral nutrition (EN) in gastrointestinal disease in children, and to explore the possibility of the implementation of family EN. METHOD: Retrospective analysis of disease spectrum, EN approach, preparation, speed and time as well as adverse reactions and outcomes in 47 pediatric patients with gastrointestinal disease underwent EN therapy during July 2014 to March 2015. The nutrition indicators before and after EN therapy were compared by paired t-test...
July 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27411415/empiric-treatment-of-children-with-gastroesophageal-reflux-like-symptoms-effect-of-proton-pump-inhibitors
#14
Mehmet Gündüz, Pınar Yamaç, Gökhan Baysoy
Gastroesophageal reflux disease is an important cause of morbidity in childhood. Although various diagnostic methods are available, short course of empiric treatment with a proton pump inhibitor is widely used in adults as a diagnostic test. Data about empiric treatment is scarce in children. The aim of this study is to evaluate the effectiveness of empiric treatment of reflux-like symptoms in children. Pediatric gastroenterology outpatient files were searched and patients with a diagnosis of gastroesophageal reflux were found...
September 2015: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27403002/domperidone-associated-qt-interval-prolongation-in-non-oncologic-pediatric-patients-a-review-of-the-literature
#15
REVIEW
Amy D Morris, Jennifer Chen, Elaine Lau, Jennifer Poh
BACKGROUND: Domperidone is a prokinetic agent used to treat pediatric gastroesophageal reflux disease. Health Canada has issued warnings about an increased risk of domperidone-associated ventricular arrhythmias and sudden cardiac death. However, the supporting data referred only to adult patients; therefore, extrapolating the safety risks to pediatric patients is difficult. OBJECTIVE: To summarize and evaluate the evidence for domperidone-associated QT interval prolongation, ventricular arrhythmias, and sudden cardiac death to determine the safety of this drug for pediatric patients...
May 2016: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/27369283/effects-and-efficacy-of-laparoscopic-fundoplication-in-children-with-gerd-a-prospective-multicenter-study
#16
Femke A Mauritz, J M Conchillo, L W E van Heurn, P D Siersema, C E J Sloots, R H J Houwen, D C van der Zee, M Y A van Herwaarden-Lindeboom
INTRODUCTION: Laparoscopic antireflux surgery (LARS) in children primarily aims to decrease reflux events and reduce reflux symptoms in children with therapy-resistant gastroesophageal reflux disease (GERD). The aim was to objectively assess the effect and efficacy of LARS in pediatric GERD patients and to identify parameters associated with failure of LARS. METHODS: Twenty-five children with GERD [12 males, median age 6 (2-18) years] were included prospectively...
July 1, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27368458/helicobacter-pylori-detection-and-clinical-symptomatology-of-gastroesophageal-reflux-disease-in-pediatric-patients-with-otitis-media-with-effusion
#17
Nuria Boronat-Echeverría, Héctor Aguirre-Mariscal, Margarita Carmolinga-Ponce, Yolanda Sevilla-Delgado, Ricardo Miceli-Flores, Aisha Kennedy-Padilla, Juan Manuel Mejía-Aranguré
OBJECTIVES: The study aimed to demonstrate Helicobacter pylori presence in otitis media with effusion (OME) and its association with symptomatology of gastroesophageal reflux disease (GERD). METHODS: In a cohort study, 69 effusions were collected during tympanostomy tube insertion for H. pylori detection using PCR and ELISA. Validated questionnaires were performed according to age for clinical diagnosis of GERD; chi-square ×2 statistical analysis was made. RESULTS: Eight of the 69 ear effusions (5...
August 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27367982/correlation-between-the-different-ph-metry-scores-in-gastroesophageal-reflux-disease-in-children
#18
Vasile Valeriu Lupu, Ancuţa Ignat, Gabriela Paduraru, Anamaria Ciubara, Mihaela Moscalu, Cristina Oana Marginean, Marin Burlea
The 24-hour esophageal pH-metry is the most widely used method to diagnose the gastroesophageal reflux disease (GERD). The study compares the different scores obtained during the 24-hour esophageal pH-metry. A retrospective study over 5 years including 234 children (1 month and 18 years old) admitted in a pediatric gastroenterology regional center in Northeast Romania, with suspicion of GERD. They underwent 24- hour esophageal pH-metry, and the scores obtained (Boix-Ochoa, DeMeester, Johnson-DeMeester) were compared...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27310521/esophageal-replacements-in-children
#19
Olivier Reinberg
Replacement of the esophagus in children can be performed in cases of malformations, injuries, or acquired conditions. The new esophagus should allow normal oral feeding, with little or no gastroesophageal reflux, and be able to work well for the lifetime of the patient. For over a century, many substitutes have been used, such as segments of colon, the entire stomach, gastric tubes, or parts of the small bowel, but none are perfect or function like a normal esophagus. Esophageal replacements are demanding challenges for pediatric surgeons...
June 16, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27279887/efficacy-of-proton-pump-inhibitors-and-h2-blocker-in-the-treatment-of-symptomatic-gastroesophageal-reflux-disease-in-infants
#20
Hamid Reza Azizollahi, Mandana Rafeey
PURPOSE: Gastroesophageal reflux disease (GERD) occurs in pediatric patients when reflux of gastric contents presents with troublesome symptoms. The present study compared the effects of omeprazole and ranitidine for the treatment of symptomatic GERD in infants of 2-12 months. METHODS: This study was a clinical randomized double-blind trial and parallel-group comparison of omeprazole and ranitidine performed at Children Training Hospital in Tabriz, Iran. Patients received a standard treatment for 2 weeks...
May 2016: Korean Journal of Pediatrics
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