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JOURNAL ARTICLE
Bright Huo, Elisa Calabrese, Patricia Sylla, Sunjay Kumar, Romeo C Ignacio, Rodolfo Oviedo, Imran Hassan, Bethany J Slater, Andreas Kaiser, Danielle S Walsh, Wesley Vosburg
BACKGROUND: Large language model (LLM)-linked chatbots may be an efficient source of clinical recommendations for healthcare providers and patients. This study evaluated the performance of LLM-linked chatbots in providing recommendations for the surgical management of gastroesophageal reflux disease (GERD). METHODS: Nine patient cases were created based on key questions addressed by the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) guidelines for the surgical treatment of GERD...
April 17, 2024: Surgical Endoscopy
#2
JOURNAL ARTICLE
Po-Yang Tsou, Ignacio E Tapia
STUDY OBJECTIVES: Congenital central hypoventilation syndrome (CCHS) is a rare disease predisposing children to respiratory failure due to abnormal ventilatory drive. Variability in hypoventilation and respiratory support need have been reported. We aim to identify clinical variables associated with incident tracheostomy and common etiologies of hospitalization among children with CCHS. METHODS: Hospital discharge records were obtained for children (<21 years) with CCHS hospitalized between 2006 and 2019 from the Kid's Inpatient Database...
April 17, 2024: Pediatric Pulmonology
#3
JOURNAL ARTICLE
Mary Peyton French, Jordan Busing, Sari Acra, Heidi Chen, Laura Stafman, Irving Zamora, Michael Holzman, Harold N Lovvorn
Introduction: Achalasia among children often fails endoscopic management (e.g., dilation, botulinum toxin). Laparoscopic esophagocardiomyotomy (L-ECM) is a standard intervention to relieve obstruction but can induce gastroesophageal reflux (GER). Concurrent anterior fundoplication (A-fundo) has been evaluated in randomized trials among adults, demonstrating mixed results on controlling postoperative GER without exacerbating dysphagia. Furthermore, evidence for the best approach among children remains sparse...
April 9, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
#4
REVIEW
Ahmed Elghoudi, Doaa Zourob, Eman Al Atrash, Fatima Alshamsi, Manal Alkatheeri, Hassib Narchi, Rana Bitar
Eosinophilic esophagitis is a newly recognized disease first described about 50 years ago. The definition, diagnosis, and management have evolved with new published consensus guidelines and newly approved treatment available to pediatricians, enabling a better understanding of this disease and more targeted treatment for patients. We describe the definition, presentation, and diagnosis of eosinophilic esophagitis including management, challenges, and future directions in children. The definition, diagnosis, and management of eosinophilic esophagitis have evolved over the last 50 years...
March 9, 2024: World Journal of Clinical Pediatrics
#5
MULTICENTER STUDY
Paola Ilaria Bianchi, Marco Vincenzo Lenti, Clarissa Petrucci, Giulia Gambini, Nicola Aronico, Matteo Varallo, Carlo Maria Rossi, Elena Pozzi, Elena Groppali, Francesca Siccardo, Giulia Franchino, Gian Vincenzo Zuccotti, Grazia Di Leo, Chiara Zanchi, Fernanda Cristofori, Ruggiero Francavilla, Marina Aloi, Giulia Gagliostro, Monica Montuori, Sara Romaggioli, Caterina Strisciuglio, Marco Crocco, Noemi Zampatti, Angela Calvi, Renata Auricchio, Costantino De Giacomo, Silvia Maria Elena Caimmi, Carolina Carraro, Annamaria Staiano, Sabrina Cenni, Mauro Congia, Enrico Schirru, Francesca Ferretti, Carolina Ciacci, Nicoletta Vecchione, Mario Andrea Latorre, Semela Resuli, Giusy Cinzia Moltisanti, Giulia Maria Abruzzese, Andrea Quadrelli, Simone Saglio, Pietro Canu, Damiano Ruggeri, Annalisa De Silvestri, Catherine Klersy, Gian Luigi Marseglia, Gino Roberto Corazza, Antonio Di Sabatino
IMPORTANCE: The extent and factors associated with risk of diagnostic delay in pediatric celiac disease (CD) are poorly understood. OBJECTIVES: To investigate the diagnostic delay of CD in childhood, and to assess factors associated with this delay. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, retrospective, cross-sectional study (2010-2019) of pediatric (aged 0-18 years) patients with CD from 13 pediatric tertiary referral centers in Italy...
April 1, 2024: JAMA Network Open
#6
REVIEW
Maria C Garganese, Milena Pizzoferro
Pediatric gastrointestinal imaging plays a crucial role in evaluating and managing digestive system disorders in children. This comprehensive review dives into the nuances of pediatric gastrointestinal imaging techniques, focusing on three specific modalities: gastric emptying scintigraphy (GES), intestinal transit scintigraphy (ITS), and gastrointestinal bleeding scintigraphy. GES involves real-time monitoring of stomach emptying using radiotracers and gamma camera technology. While challenges exist in standardizing protocols due to age-specific meal compositions, GES remains pivotal in diagnosing motility disorders, gastroesophageal reflux, and abdominal pain in children...
March 2024: Quarterly Journal of Nuclear Medicine and Molecular Imaging
#7
JOURNAL ARTICLE
Kavita Dedhia, Mitch Maltenfort, Lisa Elden, David Horn, Brianna Magnusen, Prasanth Pattisapu, Cedric V Pritchett, Todd Wine, Levon Utidjian, Christopher B Forrest
OBJECTIVES: To determine rates and risk factors of pediatric otitis media (OM) using real-world electronic health record (PEDSnet) data from January 2009 through May 2021. STUDY DESIGN: Retrospective cohort study. SETTING: Seven pediatric academic health systems that participate in PEDSnet. METHODS: Children <6 months-old at time of first outpatient, Emergency Department, or inpatient visit were included and followed longitudinally...
March 21, 2024: International Journal of Pediatric Otorhinolaryngology
#8
Marie-Louis Wronski, Ralf Kuja-Halkola, Elin Hedlund, Miriam I Martini, Paul Lichtenstein, Sebastian Lundström, Henrik Larsson, Mark J Taylor, Nadia Micali, Cynthia M Bulik, Lisa Dinkler
BACKGROUND: Avoidant restrictive food intake disorder (ARFID) is a feeding and eating disorder, characterized by limited variety and/or quantity of food intake impacting physical health and psychosocial functioning. Children with ARFID often present with a range of psychiatric and somatic symptoms, and therefore consult various pediatric subspecialties; large-scale studies mapping comorbidities are however lacking. To characterize health care needs of people with ARFID, we systematically investigated ARFID-related mental and somatic conditions in 616 children with ARFID and >30,000 children without ARFID...
March 15, 2024: medRxiv
#9
REVIEW
Sara María Fernández-González, Ana Moreno-Álvarez, Alfonso Solar-Boga
This systematic review was conducted with the objective of understanding the efficacy and safety of proton pump inhibitors (PPIs) in the pediatric population. We used PubMed to identify randomized controlled trials (RCTs) published between 1 June 2010 and 30 June 2023, performed in patients from birth to 18 years old with gastroesophageal reflux disease (GERD) who received treatment with any PPI. This literature search yielded 76 articles and 13 of these met the inclusion criteria. For infants, PPIs were equal to placebos in reducing GERD symptoms in four articles...
March 1, 2024: Children
#10
JOURNAL ARTICLE
Daiki Kato, Hiroo Uchida, Hizuru Amano, Kazuki Yokota, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Satoshi Makita, Akihiro Yasui, Yousuke Gohda, Takuya Maeda, Akinari Hinoki
PURPOSE: Sandifer syndrome (SS), which combines gastroesophageal reflux (GER) and a neurological or psychiatric disorder, is an uncommon condition that often takes a long time to diagnosis. We aimed to systematically review available papers regarding SS. METHODS: After presenting our two cases of SS, we systematically reviewed articles published in MEDILINE/PubMed, Cochrane Library, and Web of Science. RESULTS: The meta-analysis included 54 reported cases and 2 of our own cases...
March 25, 2024: Pediatric Surgery International
#11
JOURNAL ARTICLE
Ning Zhang, Wenjie Wu, Yujia Zhuang, Weipeng Wang, Weihua Pan, Jun Wang
OBJECTIVE: To summarize the experience with intraluminal esophageal stretching elongation (ILESE) in the successful treatment of long-gap esophageal atresia (LGEA) at a single center. METHODS: Clinical data of 68 neonates who underwent LGEA between February 2015 and January 2022 were retrospectively analyzed. Four patients died of multiple associated severe malformations and did not undergo ILESE. Esophageal anastomosis was successfully performed in 60 cases (93...
2024: Frontiers in Pediatrics
#12
JOURNAL ARTICLE
Özlem Gülpınar Aydın, Hüseyin Burak Baykara, Kardelen Akın, Sinem Kahveci, Gül Şeker, Yunus Güler, Yeşim Öztürk
BACKGROUND: Gastrointestinal system disorders are known to be prevalent among children with autism spectrum disorder (ASD). Some ASD-associated comorbidities are abdominal pain, constipation, diarrhea, gastroesophageal reflux, sleep disturbances, epilepsy, and psychiatric problems. Nonetheless, there is still limited information about the presence of functional GI disorders (FGIDs) among children with ASD, especially in Türkiye. Using the Rome criteria, we aimed to investigate FGIDs in children with ASD...
2024: Turkish Journal of Pediatrics
#13
REVIEW
Allison Keane, Lauren K Leeper, Amelia F Drake
The upper aerodigestive system is closely intertwined from an embryologic and functional perspective. Laryngotracheal anatomic abnormalities, such as laryngomalacia, stenosis, vocal cord paralysis, and laryngeal clefts, affect not only the respiratory function but also the swallow function. Laryngotracheal pathology can interfere with the suck-swallow-breathe mechanism in infants. It can also exacerbate gastroesophageal reflux. Chronic aspiration secondary to laryngotracheal anomalies can result in respiratory and pulmonary complications...
March 18, 2024: Otolaryngologic Clinics of North America
#14
REVIEW
Annalise B Penikis, Anne M Sescleifer, Shaun M Kunisaki
A uniquely challenging subset of infants diagnosed with esophageal atresia (EA) are those born with long-gap EA (LGEA). The common unifying feature in infants with LGEA is that the proximal and distal segments of the esophagus are too far apart to enable primary anastomosis via a single operation in the newborn period. Although any type of EA can technically result in a long gap, the Gross type A variant occurs in 8% of all EA cases and is most commonly associated with LGEA. In this review, we provide an evidence-based approach to the current challenges and management strategies employed in LGEA...
February 29, 2024: Translational Pediatrics
#15
JOURNAL ARTICLE
Débora Bressan Pazinatto, Rebecca Maunsell, Melissa Ameloti Gomes Avelino, Jose Faibes Lubianca Neto, Cláudia Schweiger, Jamil Pedro de Siqueira Caldas, Marcelo Barciela Brandão, Paula Pires de Souza, Fernanda Aparecida de Oliveira Peixoto, Claudia Pires Ricachinevsky, Rita C Silveira, Cinara Andreolio, Carolina Sponchiado Miura, Daniele da Silva Jordan Volpe, Walusa Assad Gonçalves Ferri, Fabiano Bleggi Gavazzoni, Paulo Ramos David João, Silmara Aparecida Possas, Carlos Takahiro Chone
OBJECTIVES: To make recommendations on the diagnosis and treatment of post-extubation laryngitis (PEL) in children with or without other comorbidities. METHODS: A three-iterative modified Delphi method was applied. Specialists were recruited representing pediatric otolaryngologists, pediatric and neonatal intensivists. Questions and statements approached topics encompassing definition, diagnosis, endoscopic airway evaluation, risk factors, comorbidities, management, and follow-up...
February 22, 2024: Brazilian Journal of Otorhinolaryngology
#16
JOURNAL ARTICLE
Oleg Yu Tyrsin, Dmitry Yu Tyrsin, Daniil G Nemenov, Alexey S Ruzov, Vera E Odintsova, Stanislav I Koshechkin, Luciano D Amico
Infantile functional gastrointestinal disorders, such as colic, constipation, diarrhea, and gastroesophageal reflux (regurgitation), often occur in early infancy and, representing one of the causes of significant parental anxiety, lead to a significant strain on the healthcare resources. In this study, we aimed to evaluate the effects of Lactobacillus reuteri drops (L. reuteri NCIMB 30351) on the symptoms of infantile colic, constipation, diarrhea, and gastroesophageal reflux, as well as on the levels of intestinal microbiota in full-term newborns during the first months of life...
March 1, 2024: European Journal of Pediatrics
#17
Camryn Daidone, Sheyenne Carper
We present a case of a three-year-old African American male, born at term, who initially presented with bronchiolitis at six months and has since experienced recurrent episodes of respiratory distress and hospitalizations. The patient also has severe eczema, developmental delays, and recurrent viral illnesses. Despite thorough evaluations from various specialists, such as pulmonology, allergy, and gastroenterology, the underlying cause remained elusive. The differential diagnosis for this case is as follows: severe persistent asthma with a possible link to genetic mutations such as CDHR3, hyper-IgE syndrome, atypical presentation of Wiskott-Aldrich syndrome, and severe gastroesophageal reflux disease (GERD) with aspiration pneumonitis...
January 2024: Curēus
#18
JOURNAL ARTICLE
Warren L Shapiro, Poornima Kunani, Margo A Sidell, Xia Li, Sabina R Anderson, Jeffrey M Slezak, Corinna Koebnick, Jeffrey B Schwimmer
BACKGROUND AND OBJECTIVES: The American Academy of Pediatrics endorses metabolic and bariatric surgery (MBS) as a safe and effective treatment of severe obesity in children with class 3 obesity or with class 2 obesity and qualifying comorbidities. The study objective was to determine eligibility and characteristics of adolescents who qualify for MBS based on American Academy of Pediatrics guidelines. METHODS: This retrospective cohort study analyzed electronic health record data of 603 051 adolescents aged 13 to 17 years between January 1, 2018, and December 31, 2021...
March 1, 2024: Pediatrics
#19
REVIEW
Michele Ghezzi, Nicolò Garancini, Raffaella De Santis, Laura Gianolio, Salvatore Zirpoli, Anna Mandelli, Andrea Farolfi, Enza D'Auria, Gian Vincenzo Zuccotti
Down Syndrome (DS) is the most common chromosomal abnormality compatible with life. The life of patients suffering from DS can be strongly impacted by Recurrent Respiratory tract Infections (RRIs), leading to an increased rate of hospitalisation, a higher need for intensive care and fatality. With a literature review, we summarise here the main etiological factors for RRI in this category of patients, particularly focusing on airway malformations such as tracheomalacia, tracheal bronchus and bronchomalacia, comorbidities associated with the syndrome, like congenital heart diseases, dysphagia, gastroesophageal reflux, musculoskeletal involvement and obesity, and immunologic impairments, involving both innate and adaptive immunity...
February 15, 2024: Children
#20
JOURNAL ARTICLE
Maria Giovanna Puoti, Mark Safe, Nikhil Thapar, Teresa Di Chio, Elena Sofia Pieri, Kornilia Nikaki, Keith Lindley, Anna Rybak, Osvaldo Borrelli
OBJECTIVES: Diagnosis of rumination syndrome (RS) relies on Rome IV criteria. Oesophageal high-resolution impedance manometry (HRIM) can objectively demonstrate the episodes of rumination, but its role in the diagnostic pathway is not yet established. We aimed to demonstrate the clinical contribution of this tool for the timely diagnosis of RS and diagnostic work-up of children with unexplained foregut symptoms deemed to be due to other conditions. METHODS: HRIMs performed between 2012 and 2021 were searched to retrieve all diagnoses of RS...
February 22, 2024: Journal of Pediatric Gastroenterology and Nutrition
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