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https://www.readbyqxmd.com/read/27904712/hyperbaric-oxygen-protects-mandibular-condylar-chondrocytes-from-interleukin-1%C3%AE-induced-apoptosis-via-the-pi3k-akt-signaling-pathway
#1
Hang Chen, Gaoyi Wu, Qi Sun, Yabing Dong, Huaqiang Zhao
Objectives: Mandibular condylar chondrocyte apoptosis is mainly responsible for the development and progression of temporomandibular joint osteoarthritis (TMJ-OA). Interleukin-1β (IL-1β) generally serves an agent that induces chondrocyte apoptosis. Hyperbaric oxygen (HBO) treatment increases proteoglycan synthesis in vivo. We explore the protective effect of HBO on IL-1β-induced mandibular condylar chondrocyte apoptosis in rats and the potential molecular mechanisms. Methods: Chondrocytes were isolated from the TMJ of 3-4-week old Sprague-Dawley rats...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27882078/debridement-in-chronic-osteomyelitis-with-benign-osteopetrosis-a-case-report
#2
Yu-Ping Liu, Xiang-Hua Lin, Man-Yun Yan, Bao-Quan Lin, Ming-Ying Zhuo
Osteopetrosis is a rare bone disease caused by metabolic imbalances as a result of genetic mutations. For instance, autosomal dominant osteopetrosis is caused by a missense mutation of the C1CN7 gene. This was first reported in 1904 and is thought to be caused by osteoclastic dysfunction and an impaired bone resorption ability. An accumulation of cortical bone mass during the remodeling of the medullary bone may increase the bone density and give rise to a hard marble consistency. Osteopetrosis can be divided into benign and malignant forms; however, no curative treatment exists for benign osteopetrosis...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27873505/hyperbaric-oxygen-pretreatment-improves-cognition-and-reduces-hippocampal-damage-via-p38-mitogen-activated-protein-kinase-in-a-rat-model
#3
Baisong Zhao, Yongying Pan, Zixin Wang, Haiping Xu, Xingrong Song
PURPOSE: To investigate the effects of hyperbaric oxygen (HBO) pretreatment on cognitive decline and neuronal damage in an Alzheimer's disease (AD) rat model. MATERIALS AND METHODS: Rats were divided into three groups: normal saline (NS), AD, and HBO+AD. In the AD group, amyloid β peptide (Aβ)₁₋₄₀ was injected into the hippocampal CA1 region of the brain. NS rats received NS injection. In the HBO+AD group, rats received 5 days of daily HBO therapy following Aβ₁₋₄₀ injection...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27872733/hyperhemolytic-syndrome-complicating-a-delayed-hemolytic-transfusion-reaction-due-to-anti-p1-alloimmunization-in-a-pregnant-woman-with-hbo-arab-%C3%AE-thalassemia
#4
Zoe Bezirgiannidou, Anna Christoforidou, Eftychia Kontekaki, Athanasios G Anastasiadis, Spyros I Papamichos, Helen Menexidou, Dimitrios Margaritis, Georges Martinis, Elpis Mantadakis
BACKGROUND: Hyperhemolytic Syndrome or Hyperhemolytic Transfusion Reaction (HHTR), a life-threatening subset of Delayed Hemolytic Transfusion Reaction (DHTR) is characterized by destruction of both transfused and autologous erythrocytes evidenced by a fall in post transfusion hemoglobin below the pre-transfusion level. CASE REPORT: We describe a case of DHTR due to anti-P1 alloimmunization manifesting with hyperhemolysis in a 30-year-old Greek Pomak woman with thalassemia intermedia (HbO-Arab/β-thalassemia), during the11(th) week of her first gestation...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27867486/effects-of-normobaric-versus-hyperbaric-oxygen-on-cell-injury-induced-by-oxygen-and-glucose-deprivation-in-acute-brain-slices
#5
Laurent Chazalviel, Jean-Eric Blatteau, Nicolas Vallée, Jean-Jacques Risso, Stéphane Besnard, Jacques H Abraini
Normobaric oxygen (NBO) and hyperbaric oxygen (HBO) are emerging as a possible co-treatment of acute ischemic stroke. Both have been shown to reduce infarct volume, to improve neurologic outcome, to promote endogenous tissue plasminogen activator-induced thrombolysis and cerebral blood flow, and to improve tissue oxygenation through oxygen diffusion in the ischemic areas, thereby questioning the interest of HBO compared to NBO. In the present study, in order to investigate and compare the oxygen diffusion effects of NBO and HBO on acute ischemic stroke independently of their effects at the vascular level, we used acute brain slices exposed to oxygen and glucose deprivation, an ex vivo model of brain ischemia that allows investigating the acute effects of NBO (partial pressure of oxygen (pO2) = 1 atmospheres absolute (ATA) = 0...
July 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27867469/hyperbaric-oxygen-increases-tissue-plasminogen-activator-induced-thrombolysis-in-vitro-and-reduces-ischemic-brain-damage-and-edema-in-rats-subjected-to-thromboembolic-brain-ischemia
#6
Laurent Chazalviel, Benoit Haelewyn, Mickael Degoulet, Jean-Eric Blatteau, Nicolas Vallée, Jean-Jacques Risso, Stéphane Besnard, Jacques H Abraini
Recent data have shown that normobaric oxygen (NBO) increases the catalytic and thrombolytic efficiency of recombinant tissue plasminogen activator (rtPA) in vitro, and is as efficient as rtPA at restoring cerebral blood flow in rats subjected to thromboembolic brain ischemia. Therefore, in the present study, we studied the effects of hyperbaric oxygen (HBO) (i) on rtPA-induced thrombolysis in vitro and (ii) in rats subjected to thromboembolic middle cerebral artery occlusion-induced brain ischemia. HBO increases rtPA-induced thrombolysis in vitro to a greater extent than NBO; in addition, HBO treatment of 5-minute duration, but not of 25-minute duration, reduces brain damage and edema in vivo...
April 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27864508/radiotherapy-using-imrt-boosts-after-hyperbaric-oxygen-therapy-with-chemotherapy-for-glioblastoma
#7
Katsuya Yahara, Takayuki Ohguri, Hiroki Udono, Junkoh Yamamoto, Kyosuke Tomura, Toshihiro Onoda, Hajime Imada, Shigeru Nishizawa, Yukunori Korogi
The purpose of this study was to evaluate the feasibility and efficacy of radiotherapy (RT) using intensity-modulated radiotherapy (IMRT) boosts after hyperbaric oxygen (HBO) therapy with chemotherapy in patients with glioblastoma. Twenty-four patients with glioblastoma were treated with the combined therapy, which was RT using IMRT boosts after HBO with chemotherapy, and were retrospectively analyzed. The RT protocol was as follows: first, 3D conformal RT [40 Gy/20 fractions (fr)] was delivered to the gross tumor volume (GTV) and the surrounding edema, including an additional 1...
November 17, 2016: Journal of Radiation Research
https://www.readbyqxmd.com/read/27857747/neuroprotection-of-hyperbaric-oxygen-therapy-in-sub-acute-traumatic-brain-injury-not-by-immediately-improving-cerebral-oxygen-saturation-and-oxygen-partial-pressure
#8
Bao-Chun Zhou, Li-Jun Liu, Bing Liu
Although hyperbaric oxygen (HBO) therapy can promote the recovery of neural function in patients who have suffered traumatic brain injury (TBI), the underlying mechanism is unclear. We hypothesized that hyperbaric oxygen treatment plays a neuroprotective role in TBI by increasing regional transcranial oxygen saturation (rSO2) and oxygen partial pressure (PaO2). To test this idea, we compared two groups: a control group with 20 healthy people and a treatment group with 40 TBI patients. The 40 patients were given 100% oxygen of HBO for 90 minutes...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27849544/imagined-hand-clenching-force-and-speed-modulate-brain-activity-and-are-classified-by-nirs-combined-with-eeg
#9
Yunfa Fu, Xin Xiong, Changhao Jiang, Baolei Xu, Yongcheng Li, Hongyi Li
Simultaneous acquisition of brain activity signals from the sensorimotor area using NIRS combined with EEG, imagined hand clenching force and speed modulation of brain activity, as well as 6-class classification of these imagined motor parameters by NIRS-EEG were explored. Near infrared probes were aligned with C3 and C4, and EEG electrodes were placed midway between the NIRS probes. NIRS and EEG signals were acquired from 6 healthy subjects during 6 imagined hand clenching force and speed tasks involving the right hand...
November 10, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27826422/hyperbaric-oxygen-modalities-are-differentially-effective-in-distinct-brain-ischemia-models
#10
REVIEW
Robert P Ostrowski, Katarzyna Stępień, Emanuela Pucko, Ewa Matyja
The effectiveness and efficacy of hyperbaric oxygen (HBO) preconditioning and post-treatment modalities have been demonstrated in experimental models of ischemic cerebrovascular diseases, including global brain ischemia, transient focal and permanent focal cerebral ischemia, and experimental neonatal hypoxia-ischemia encephalopathy. In general, early and repetitive post-treatment of HBO appears to create enhanced protection against brain ischemia whereas delayed HBO treatment after transient focal ischemia may even aggravate brain injury...
March 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27826420/hyperbaric-oxygen-preconditioning-a-reliable-option-for-neuroprotection
#11
REVIEW
Qin Hu, Anatol Manaenko, Nathanael Matei, Zhenni Guo, Ting Xu, Jiping Tang, John H Zhang
Brain injury is the leading cause of death and disability worldwide and clinically there is no effective therapy for neuroprotection. Hyperbaric oxygen preconditioning (HBO-PC) has been experimentally demonstrated to be neuroprotective in several models and has shown efficiency in patients undergoing on-pump coronary artery bypass graft (CABG) surgery. Compared with other preconditioning stimuli, HBO is benign and has clinically translational potential. In this review, we will summarize the results in experimental brain injury and clinical studies, elaborate the mechanisms of HBO-PC, and discuss regimes and opinions for future interventions in acute brain injury...
March 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27818001/simultaneous-eeg-fnirs-reveals-how-age-and-feedback-affect-motor-imagery-signatures
#12
Catharina Zich, Stefan Debener, Ann-Kathrin Thoene, Ling-Chia Chen, Cornelia Kranczioch
Stroke frequently results in motor impairment. Motor imagery (MI), the mental practice of movements, has been suggested as a promising complement to other therapeutic approaches facilitating motor rehabilitation. Of particular potential is the combination of MI with neurofeedback (NF). However, MI NF protocols have been largely optimized only in younger healthy adults, although strokes occur more frequently in older adults. The present study examined the influence of age on the neural correlates of MI supported by electroencephalogram (EEG)-based NF and on the neural correlates of motor execution...
October 15, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27817884/synergistic-effects-of-hbo-and-prp-improve-bone-regeneration-with-autologous-bone-grafting
#13
Johannes Schneppendahl, Pascal Jungbluth, Martin Sager, Laurentiu Benga, Monika Herten, Armin Scholz, Michael Wild, Mohssen Hakimi, Joachim Windolf, Jan-Peter Grassmann
Bone defects remain a challenge for patients and orthopaedic surgeons. Autologous transfer of cancellous bone grafts remains the standard of care. However, in recent years various osteoinductive substitute materials, such as platelet rich plasma (PRP) and hyperbaric oxygen therapy (HBO) have been shown to improve bone healing. This study evaluates the effects of a combined application of PRP and HBO with autologous bone grafting in an animal model. In 48 New Zealand White rabbits bone defects at the radius were filled with autologous bone harvested at the iliac crest...
December 2016: Injury
https://www.readbyqxmd.com/read/27812334/comparable-cerebral-oxygenation-patterns-in-younger-and-older-adults-during-dual-task-walking-with-increasing-load
#14
Sarah A Fraser, Olivier Dupuy, Philippe Pouliot, Frédéric Lesage, Louis Bherer
The neuroimaging literature on dual-task gait clearly demonstrates increased prefrontal cortex (PFC) involvement when performing a cognitive task while walking. However, findings from direct comparisons of the cerebral oxygenation patterns of younger (YA) and older (OA) adults during dual-task walking are mixed and it is unclear how YA and OA respond to increasing cognitive load (difficulty) while walking. This functional near infra-red (fNIRS) study examined cerebral oxygenation of YA and OA during self-paced dual-task treadmill walking at two different levels of cognitive load (auditory n-back)...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27788178/bundled-optode-method-in-functional-near-infrared-spectroscopy
#15
Hoang-Dung Nguyen, Keum-Shik Hong, Yong-Il Shin
In this paper, a theory for detection of the absolute concentrations of oxy-hemoglobin (HbO) and deoxy-hemoglobin (HbR) from hemodynamic responses using a bundled-optode configuration in functional near-infrared spectroscopy (fNIRS) is proposed. The proposed method is then applied to the identification of two fingers (i.e., little and thumb) during their flexion and extension. This experiment involves a continuous-wave-type dual-wavelength (760 and 830 nm) fNIRS and five healthy male subjects. The active brain locations of two finger movements are identified based on the analysis of the t- and p-values of the averaged HbOs, which are quite distinctive...
2016: PloS One
https://www.readbyqxmd.com/read/27765004/the-effect-of-hyperbaric-oxygen-therapy-on-rhabdomyolysis-induced-myoglobinuric-acute-renal-failure-in-rats
#16
Gamze Cebi, Şenol Yildiz, Gunalp Uzun, Yeşim Oztas, Suna Sabuncuoglu, Ayhan Kutlu, Yasin Ilgaz, Iclal Karatop-Cesur, Eyup Dogan, Emin Oztas
Myoglobinuric acute renal failure (MARF) may develop after severe muscle injury. Heme oxygenase-1 (HO-1), a stress-response protein, has been implicated as a protective agent against MARF. We hypothesized that hyperbaric oxygen therapy (HBOT) may alleviate MARF by inducing renal HO-1 expression. Wistar-Albino rats were randomly assigned into three groups: Control (n = 4), MARF (n = 8), MARF + HBO (n = 8). MARF was induced by intramuscular glycerol (50%, 8 mL/kg) injection. Saline (8 mL/kg) was injected into the hind limb of the animals in the control group...
October 20, 2016: Renal Failure
https://www.readbyqxmd.com/read/27760758/erythropoietin-modulation-is-associated-with-improved-homing-and-engraftment-post-umbilical-cord-blood-transplantation
#17
Omar S Aljitawi, Soumen Paul, Avishek Ganguly, Tara L Lin, Sid Ganguly, George Vielhauer, Maegan L Capitano, Amy Cantelina, Brea Lipe, Jonathan D Mahnken, Amanda Wise, Abigale Berry, Anurag K Singh, Leyla Shune, Christopher Lominska, Sunil Abhyankar, Dennis Allin, Mary Laughlin, Joseph P McGuirk, Hal E Broxmeyer
Umbilical cord blood (UCB) engraftment is in part limited by graft cell dose, generally one log less than that of bone marrow (BM)/peripheral blood (PB) cell grafts. Strategies toward increasing hematopoietic stem/progenitor cell (HSPC) homing to BM have been assessed in order to improve UCB engraftment. Despite recent progress, a complete understanding of how HSPC homing and engraftment are regulated is still elusive. We provide evidence that blocking erythropoietin (EPO)-EPO receptor (R) signaling promotes homing to BM and early engraftment of UCB CD34(+) cells...
October 19, 2016: Blood
https://www.readbyqxmd.com/read/27734611/hyperbaric-oxygen-therapy-sensitizes-nimustine-treatment-for-glioma-in-mice
#18
Zhaohui Lu, Jiawei Ma, Bing Liu, Chungang Dai, Tao Xie, Xiaoyu Ma, Ming Li, Jun Dong, Qing Lan, Qiang Huang
Nimustine (ACNU) has antitumor activities in patients with malignant glioma. Hyperbaric oxygen (HBO) may enhance the efficacy of certain therapies that are hampered by the hypoxic microenvironment. We examined the combined effects of ACNU and HBO in a GFP transgenic nude mice bearing human glioma model. Mice inoculated with human glioma cells SU3 were randomly divided into the four groups: (A) the control group, (B) the HBOT (HBO therapy) group, (C) the ACNU group, and (D) the HBOT+ACNU group. Tumor size was measured at the indicated time intervals with a caliper; mice were sacrificed 28 days after treatment, and immunohistochemistry staining and western blot analysis were carried out...
November 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27728941/the-explore-trial-a-feasibility-study-using-fluorescence-angiography-to-evaluate-perfusion-in-the-oxygen-rich-environment
#19
Jonathan F Arnold, Melissa Roscum
INTRODUCTION: Hyperbaric oxygen therapy (HBOT) is defined as breathing 100% oxygen at a pressure ≥1.4 atmospheres absolute (ATA). Adjunct HBOT is one modality used for treatment of certain complex wounds. The resulting increase in oxygen delivery to wounded tissue has been associated with reduced edema, reduced inflammation, improved infection control, increased collagen deposition, and increased angiogenesis. However, there remains a relative paucity of evidence supporting the use of HBOT in the treatment of certain acute and chronic, non-healing wounds...
October 10, 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27725827/analysis-of-different-classification-techniques-for-two-class-functional-near-infrared-spectroscopy-based-brain-computer-interface
#20
Noman Naseer, Nauman Khalid Qureshi, Farzan Majeed Noori, Keum-Shik Hong
We analyse and compare the classification accuracies of six different classifiers for a two-class mental task (mental arithmetic and rest) using functional near-infrared spectroscopy (fNIRS) signals. The signals of the mental arithmetic and rest tasks from the prefrontal cortex region of the brain for seven healthy subjects were acquired using a multichannel continuous-wave imaging system. After removal of the physiological noises, six features were extracted from the oxygenated hemoglobin (HbO) signals. Two- and three-dimensional combinations of those features were used for classification of mental tasks...
2016: Computational Intelligence and Neuroscience
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