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https://www.readbyqxmd.com/read/29896427/evaluation-of-hyperbaric-oxygen-treatment-in-acute-traumatic-spinal-cord-injury-in-rats-using-diffusion-tensor-imaging
#1
Wenzhi Sun, Jiewen Tan, Zhuo Li, Shibao Lu, Man Li, Chao Kong, Yong Hai, Chunjin Gao, Xuehua Liu
This study aimed to evaluate the therapeutic effect of hyperbaric oxygen (HBO) on acute spinal cord injury (SCI) by measuring the in vivo diffusion tensor imaging (DTI) parameters apparent diffusion coefficient (ADC) and fractional anisotropy (FA) and observing diffusion tensor tractography (DTT) of fiber bundle morphology. The rats were randomly divided into sham-operated (SH), SCI, and SCI and hyperbaric oxygen treatment (SCI + HBO) groups (n = 6 in each group). The Basso-Bettie-Bresnahan (BBB) score was used to evaluate motor function recovery, and DTI was performed on days 3, 7, 14, and 21 after surgery...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29895816/combined-hyperbaric-oxygen-partial-pressure-at-1-4-bar-with-infrared-radiation-a-useful-tool-to-improve-tissue-hypoxemia
#2
Tobias Dünnwald, Julia Held, Petru Balan, Otto Pecher, Thomas Zeiger, Frank Hartig, Erich Mur, Günter Weiss, Wolfgang Schobersberger
Tissue hypoxia contributes to the pathogenesis of several acute and chronic diseases. Hyperbaric oxygen therapy (HBO) and whole-body warming using low-temperature infrared technology (LIT) are techniques that might improve hypoxemia. Combining HBO and LIT as hyperbaric oxygen therapy combined with low-temperature infrared radiation (HBOIR) might be an approach that results in positive synergistic effects on oxygenation. LIT increases blood flow and could reduce HBO-induced vasoconstriction, and hyperoxia could compensate for the increased metabolic oxygen requirements mediated by LIT...
June 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29891394/comparison-of-intratympanic-dexamethasone-therapy-and-hyperbaric-oxygen-therapy-for-the-salvage-treatment-of-refractory-high-frequency-sudden-sensorineural-hearing-loss
#3
Hongcun Sun, Xiaowen Qiu, Jiandao Hu, Zhaoxin Ma
OBJECTIVE: This study aimed to compare the efficacy of intratympanic dexamethasone (ITD) therapy and hyperbaric oxygen(HBO) therapy for the salvage treatment of patients with high-frequency sudden sensorineural hearing loss (SSNHL) after the failure of conventional therapy. MATERIALS AND METHODS: 104 refractory high-frequency SSNHL patients were enrolled in our study. Among them, 31 received ITD alone (ITD group), 32 received HBO alone (HBO group) and 41 received no salvage therapies (control group)...
June 5, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29877702/synergizing-upconversion-nanophotosensitizers-with-hyperbaric-oxygen-to-remodel-extracellular-matrix-for-enhanced-photodynamic-cancer-therapy
#4
Jingqiu Li, Jinzhao Huang, Yanxiao Ao, Shiyu Li, Yu Miao, Zhongzheng Yu, Lingtao Zhu, Yanhong Zhu, Yan Zhang, Xiangliang Yang
Photodynamic therapy (PDT) holds great promise as a non-invasive and selective cancer therapeutic treatment in preclinic research and clinical practise; however, it has limited efficacy in the ablation of deep-seated tumor due to hypoxia-associated circumstance and poor penetration of photosensitizers to cancer cells away from the blood vessels. To tackle the obstacles, we propose a therapeutic strategy that synergizes upconversion nanophotosensitizers (UNPSs) with hyperbaric oxygen (HBO) to remodel the extracellular matrix for enhanced photodynamic cancer therapy...
June 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29851032/interventions-for-necrotizing-soft-tissue-infections-in-adults
#5
REVIEW
Camille Hua, Romain Bosc, Emilie Sbidian, Nicolas De Prost, Carolyn Hughes, Patricia Jabre, Olivier Chosidow, Laurence Le Cleach
BACKGROUND: Necrotizing soft tissue infections (NSTIs) are severe and rapidly spreading soft tissue infections of the subcutaneous tissue, fascia, or muscle, which are mostly caused by bacteria. Associated rates of mortality and morbidity are high, with the former estimated at around 23%, and disability, sequelae, and limb loss occurring in 15% of patients. Standard management includes intravenous empiric antimicrobial therapy, early surgical debridement of necrotic tissues, intensive care support, and adjuvant therapies such as intravenous immunoglobulin (IVIG)...
May 31, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29808324/randomized-controlled-trial-of-hyperbaric-oxygen-therapy-in-adhesive-postoperative-small-bowel-obstruction
#6
Yasuyuki Fukami, Satoshi Kobayashi, Ei Sekoguchi, Yasuhiro Kurumiya
BACKGROUND: Hyperbaric oxygen (HBO) therapy is a controversial treatment for adhesive postoperative small bowel obstruction (ASBO), with only a few retrospective studies reported. The aim of this study was to assess the clinical impact of HBO therapy in the treatment of ASBO. METHODS: Patients with ASBO were randomly assigned to no-HBO (standard arm) or HBO (intervention arm). Patients of the intervention arm were treated once daily at a pressure of 2.0 atm absolute and received 100% oxygen...
May 28, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29805482/effect-of-hyperbaric-oxygen-combined-with-nimodipine-on-treatment-of-diffuse-brain-injury
#7
Jianping Sun, Jun Zheng, Feng Wang, Gengshen Zhang, Jianliang Wu
The aim of the present study was to was investigate the treatment efficacy of hyperbaric oxygen (HBO) combined with nimodipine on diffuse brain injury. AA total of 80 patients with diffuse brain injury were randomly divided into four groups: Group A, conventional treatment; Group B, conventional treatment + nimodipine; Group C, conventional treatment + HBO therapy and Group D, conventional treatment + nimodipine + HBO therapy. The Glasgow Coma Scale (GCS) score and serum tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels were assessed before treatment and at 8, 24, 48 and 72 h after treatment...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29798984/-assessment-of-the-efficacy-of-mexidol-in-the-combination-with-hyperbaric-oxygen-in-acute-ischemic-stroke
#8
N S Kulai, E Yu Kovalchuk
To study the efficacy of mexidol in the combination with hyperbaric oxygenation (HBO) in comparison with the standard HBO sessions in patients with acute ischemic stroke. One hundred and twelve patients were examined. In the main group, 48 patients underwent HBO and received treatment with mexidol. The control group consisted of 64 people who underwent the standard HBO sessions only. The use of combination therapy (HBO+mexidol) leads to the significantly more rapid normalization of acute phase indices which are correlated with neurological deficit reduction...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29785863/hyperbaric-oxygen-inhibits-production-of-cd3-t-cells-in-the-thymus-and-facilitates-malignant-glioma-cell-growth
#9
Yong-Gang Wang, Jiang Long, Dong-Chuan Shao, Hai Song
Objective Hyperbaric oxygen (HBO) is an emerging complementary alternative medical approach in glioma treatment. However, its mode of action is unknown, so this was investigated in the present study. Methods We constructed an intracranial glioma model of congenic C57BL/6J mice. Glioma growth under HBO stimulation was assessed by bioluminescent imaging and magnetic resonance imaging. Flow cytometry assessed direct effects of HBO on reactive oxygen species (ROS) signaling of transplanted glioma cells and organs, and quantified mature T cells and subgroups in tumors, the brain, and blood...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29768537/the-protection-effect-and-mechanism-of-hyperbaric-oxygen-therapy-in-rat-brain-with-traumatic-injury
#10
Pengcheng Xing, Ke Ma, Lijuan Li, Donglian Wang, Guoyong Hu, Wei Long
PURPOSE: To investigate the effect of hyperbaric oxygen therapy (HBOT) on traumatic brain injury (TBI) outcome. METHODS: The modified Marmarou's weight drop device was used to generate non-lethal moderate TBI rat model, and further developed in vitro astrocytes culturing system. Then, we analyzed the expression changes of interested genes and protein by quantitative PCR and western blot. RESULTS: Multiple HBO treatments significantly reduced the expression of apoptosis promoting genes, such as c-fos, c-jun, Bax and weakened the activation of Caspase-3 in model rats...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29761012/an-overview-of-protective-strategies-against-ischemia-reperfusion-injury-the-role-of-hyperbaric-oxygen-preconditioning
#11
Ciprian Hentia, Alex Rizzato, Enrico Camporesi, Zhongjin Yang, Danina M Muntean, Dorel Săndesc, Gerardo Bosco
Introduction: Ischemia/reperfusion (I/R) injury, such as myocardial infarction, stroke, and peripheral vascular disease, has been recognized as the most frequent causes of devastating disorders and death currently. Protective effect of various preconditioning stimuli, including hyperbaric oxygen (HBO), has been proposed in the management of I/R. Methods: In this study, we searched and reviewed up-to-date published papers to explore the pathophysiology of I/R injury and to understand the mechanisms underlying the protective effect of HBO as conditioning strategy...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29755808/the-role-of-duration-of-hyperbaric-oxygen-therapy-on-lung-injury-an-experimental-study-lung-injury-and-hyperbaric-oxygen-therapy
#12
Menduh Oruç, Bennur Esen, Maşuk Taylan, Yusuf Nergis, Atalay Şahin
OBJECTIVES: We aim to histopathologically analyze the effect of hyperbaric oxygen (HBO) therapy in the lung tissue. MATERIAL AND METHODS: A total of 21 rabbits were divided into three groups, with each containing seven rabbits. Group 1 was the control group. Group 2 underwent HBO of 3 atmosphere absolute (ATA) for 90 min/day for 7 days. In group 3, HBO at 3 ATA was administered 90 min/day for 28 days. Oxygen saturation (SpO2 ) was determined by pulse oximetry before and after administration of HBO...
April 2018: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29749479/effect-of-combined-chondroitinase-abc-and-hyperbaric-oxygen-therapy-in-a-rat-model-of-spinal-cord-injury
#13
Xiaoyang Liu, Jiefeng Wang, Guangkuo Li, Honglin Lv
The present study aimed to investigate the effect of combined hyperbaric oxygen (HBO) and chondroitinase ABC (ChABC) enzyme therapy in a rat model of spinal cord injury (SCI) and to explore the underlying mechanisms. A total of 48 healthy male Wistar rats were randomly divided into six groups: Sham, SCI, vehicle, HBO, ChABC enzyme and HBO + ChABC. Excluding the sham group, SCI was established in rats by a clip compression injury and rats subsequently received HBO treatment for 2 weeks with or without an intraspinal injection of 0...
April 26, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29734574/sensorineural-hearing-loss-after-spine-surgery-treated-with-hyperbaric-oxygen-therapy-two-case-reports
#14
Eric Goodrich, Richard P Goodrich, Charles A Reese
Acute idiopathic sudden sensorineural hearing loss (ISSNHL) following lumbar spinal surgery is an exceedingly rare phenomenon. This paper presents a case of ISSNHL presenting acutely after lumbar spine decompression and fusion treated with transtympanic steroids and hyperbaric oxygen (HBO₂) therapy. It also presents the ironic case of SSNHL secondary to presumed viral pathology sustained by the patient's operative surgeon who was treated with transtympanic steroids and HBO₂ as well. Proposed etiologies of the patient's ISSNHL include: hypotension, prone operative position, malfitted/malpositioned headrest, microemboli from a cell-saver, and nitrous oxide anesthesia...
March 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29734571/spirometry-and-oxidative-stress-after-rebreather-diving-in-warm-water
#15
Gerardo Bosco, Alex Rizzato, Silvia Quartesan, Enrico Camporesi, Simona Mrakic-Sposta, Sarah Moretti, Costantino Balestra, Alessandro Rubini
Introduction: Hyperbaric oxygen (HBO₂) therapy and use of enriched air can result in oxidative injury affecting the brain, lungs and eyes. HBO₂ exposure during diving can lead to a decrease in respiratory parameters. However, the possible effects of acute exposure to oxygen-enriched diving on subsequent spirometric performance and oxidative state in humans have not been recently described recently. We aim to investigate possible effects of acute (i) hyperbaric and (ii) hyperbaric hyperoxic exposure using scuba or closed-circuit rebreather (CCR) on subsequent spirometry and to assess the role of oxidative state after hyperoxic diving...
March 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29734567/random-flap-survival-with-hyperbaric-oxygen-daily-versus-twice-daily-treatments
#16
Rachel Weber, Andrew Silver, Shelley J Williams, Linda Stephenson, Phillip C Usera, Fan Zhang, Honglin Tian, Wei Yang, Wei Z Wang, Xin Hua Fang, William A Zamboni, Richard Baynosa
Purpose: Hyperbaric oxygen (HBO₂) therapy is used to improve the survival of compromised flaps. Compromised flaps are complications encountered postsurgically, or in traumatic degloving or avulsion injuries. Failed flaps lead to persistence of the defect, requirement of another donor site, and psychosocial sequelae. Although evidence of the benefit of HBO₂ therapy is significant, there is no consensus on the optimal treatment regimen. The purpose of this study is to examine whether twice-daily treatments (BID HBO₂) provide additional benefit compared to daily treatments (QD HBO₂) in a rat compromised random flap model...
March 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29734566/hyperbaric-oxygen-for-post-concussive-symptoms-in-united-states-military-service-members-a-randomized-clinical-trial
#17
Lindell K Weaver, Steffanie H Wilson, Anne S Lindblad, Susan Churchill, Kayla Deru, Robert C Price, Chris S Williams, William W Orrison, James M Walker, Anna Meehan, Susan Mirow
Background: In prior military randomized trials, participants with persistent symptoms after mild traumatic brain injury (TBI) reported improvement regardless of receiving hyperbaric oxygen (HBO₂) or sham intervention. This study's objectives were to identify outcomes for future efficacy trials and describe changes by intervention. Methods: This Phase II, randomized, double-blind, sham-controlled trial enrolled military personnel with mild TBI and persistent post-concussive symptoms...
March 2018: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29678841/the-effect-of-hyperbaric-oxygen-therapy-on-myocardial-perfusion-after-the-implantation-of-drug-eluting-stents
#18
Yuan Li, Yafeng Hao, Tao Wang, Lingge Wei, Wei Wang, Yi Liang, Xuan Guo
AIM: The study is to investigate hyperbaric oxygen therapy (HBOT) on myocardial perfusion of patients after the implantation of drug-eluting stents (DES) METHODS: From December 2013 to December 2015, a total of 115 patients with CAD who received DES implantation were included in this retrospective study. They were divided into HBOT group (n=55) and control group (n=60) according to different treatments retrospectively. Gated myocardial perfusion single photon emission computed tomography (SPECT) was conducted in all the patients...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29665051/hyperbaric-oxygen-treatment-sensitizes-gastric-cancer-cells-to-melatonin-induced-apoptosis-through-multiple-pathways
#19
Xiang Wei, Yinliang Qi, Ning Jia, Qing Zhou, Sumei Zhang, Yuan Wang
Although extensive efforts have been made in recent decades to treat advanced gastric cancer with comprehensive therapy based on chemotherapy, effective anti-gastric cancer therapeutics are still lacking in the clinics. Therefore, potent novel anti-gastric cancer ways are greatly needed. Here, we explored hyperbaric oxygen treatment as a novel and effective adjuvant treatment method which has anti-gastric cancer effects when used together with melatonin. When performed together with MLT, HBO effectively inhibited tumorigenicity of gastric cancer through selectively inducing a robust tumor suppressive apoptosis response...
April 17, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29607850/the-neuroprotection-effect-of-oxygen-therapy-a-systematic-review-and-meta-analysis
#20
REVIEW
Z Deng, W Chen, J Jin, J Zhao, H Xu
This study reviews the oxygen therapy (normobaric oxygen [NBO] and hyperbaric oxygen [HBO]) in both stroke and traumatic brain injury (TBI) patients and meta-analyzes the efficacy of two oxygen therapies in different kinds of injuries. In stroke patients, NBO showed significant improvement in reperfusion rate while there is no favorable outcome effect of HBO treatment. In patients with TBI, HBO showed significant improvement of Glasgow outcome scale score and reduction of overall mortality while NBO may play a favorable role in improving brain metabolism...
April 2018: Nigerian Journal of Clinical Practice
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