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Su-Qin Zhang, Cheng Zheng, Yue-Chun Li, Kang-Ting Ji, Ri-Peng Yin, Jia-Feng Lin, Jia Li
OBJECTIVE: To investigate electrocardiographic (ECG) characteristics and radiofrequency catheter ablation (RFCA) efficacy for premature ventricular complexes (PVCs) and idiopathic ventricular tachycardias (IVTs) originating from ventricular septum areas adjacent to atrioventricular annulus (VS-AVA). METHODS: Among 1505 consecutive PVCs/IVTs cases, 106 (7.04%) were confirmed as origin of VS-AVA guided by both fluoroscopy and three-dimensional mapping system during RFCA...
May 21, 2018: Journal of Cardiovascular Electrophysiology
Vessela Krasteva, Irena Jekova, Ramun Schmid
OBJECTIVE: This study aims to validate the 12-lead electrocardiogram (ECG) as a biometric modality based on two straightforward binary QRS template matching characteristics. Different perspectives of the human verification problem are considered, regarding the optimal lead selection and stability over sample size, gender, age, heart rate (HR). METHODS: A clinical 12-lead resting ECG database, including a population of 460 subjects with two-session recordings (>1 year apart) is used...
2018: PloS One
Jason A Thomas, Erick Andres Perez-Alday, Christopher Hamilton, Muammar M Kabir, Eugene A Park, Larisa G Tereshchenko
INTRODUCTION: The subcutaneous implantable cardioverter-defibrillator (S-ICD) is a life-saving device. Recording of a specialized 3-lead electrocardiogram (ECG) is required for S-ICD eligibility assessment. The goals of this study were: (1) evaluate the effect of ECG filtering on S-ICD eligibility, and (2) simplify S-ICD eligibility assessment by development of an S-ICD ineligibility prediction tool, which utilizes the widely available routine 12-lead ECG. METHODS AND RESULTS: Prospective cross-sectional study participants [n = 68; 54% male; 94% white, with wide ranges of age (18-81 y), body mass index (19-53), QRS duration (66-150 ms), and left ventricular ejection fraction (37-77%)] underwent 12-lead supine, 3-lead supine and standing ECG recording...
May 8, 2018: Computers in Biology and Medicine
Bruna de Gois Macêdo, Rephany Fonseca Peixoto, Bruna Leal Lima Maciel, Juliana de Assis Silva Gomes, Fátima de Lourdes Assunção Araújo de Azevedo, Robson Cavalcanti Veras, Isac Almeida de Medeiros, Teresa Cristina Soares de Lima Grisi, Demétrius Antônio Machado de Araújo, Ian Porto Gurgel do Amaral, Tatjana Keesen de Souza Lima
Although the semi-invariant natural killer T cells (iNKT) are a small subpopulation of cells in the peripheral blood, they are presumed to play a role in early stages of infection against various pathogens, including protozoa. This work investigates the activation status and cytokine profile of iNKT cells during human Leishmania infantum and Leishmania braziliensis infection. We studied iNKT cells in symptomatic active visceral patients (AVL) (n=8), symptomatic active cutaneous patients (ACL) (n=13), negative endemic controls (NEC) (n=6) and non-endemic controls (NonEC) (n=6), with and without Total Leishmania antigen stimulus (TLA)...
April 27, 2018: Scandinavian Journal of Immunology
Richard Tee, Wayne Allan Morrison, Rodney J Dilley
BACKGROUND: The survival of engineered cardiac muscle 'grafts' to the epicardium is limited by vascularization post-transplantation in rat models. In this article, we describe the methodology of a novel rat model that allows for the transplantation of an engineered cardiac muscle flap (ECMF) onto the epicardium. MATERIALS AND METHODS: A total of 40 rats were used. Twenty-four neonatal rats were used to harvest cardiomyocytes. At week 1, ECMF were generated by seeding cardiomyocytes into the arteriovenous loop (AVL) tissue engineering chamber implanted into the right groin of adult rats (n = 8)...
April 6, 2018: Microsurgery
Guo-Liang Li, Ardan M Saguner, Deniz Akdis, Guy Hugues Fontaine
BACKGROUND: Depolarization abnormalities are hardly detectable by standard 12-lead ECG in some patients. OBJECTIVE: To evaluate the value of the 16-lead HD-ECG machine to record conduction abnormalities including Epsilon waves in patients with structural heart disease. METHODS: Tracings with 12-lead ECG, 16-lead HD-ECG and SAECG were studied. RESULTS: 1. Case of severe CAD On 16-lead HD-ECG, a tiny intra QRS signal was noted in lead-III, a prolonged P wave in lead-II, and fragmentation on top of lead-aVL and lead-aVF...
March 30, 2018: Pacing and Clinical Electrophysiology: PACE
Kavita Agrawal, Levin Miles, Nirav Agrawal, Asim Khan
We present a case of a 48-year-old male who presented with worsening pleuritic chest pain for 2 h. He also complained of fever, malaise, headache and severe neck pain. Electrocardiogram (ECG) showed ST segment elevation in leads I, II, aVL and V5 with PR elevation and ST depression in aVR. On admission, troponin-I was 14.8 ng/mL. Based on ECG changes, elevated troponin and family history of early coronary artery disease, the patient was emergently taken to cardiac catheterization lab. Angiography showed non-obstructive coronaries, mild hypokinesis of mid inferior and anterolateral wall with ejection fraction (EF) of 40-45%...
February 2018: World Journal of Oncology
Huiqiang Wei, Jiaojiao Tang, Dongli Chen, Qianhuan Zhang, Yuanhong Liang, Lie Liu, Shulin Wu, Chunying Lin, Zhiming Yang, Chanjuan Chai
BACKGROUND: Electrocardiographic (ECG) characteristics of true right ventricular outflow tract (RVOT) septal pacing have not been clearly demonstrated. HYPOTHESIS: We hypothesized that ECG parameters would help operators differentiate true RVOT septum from non-septal septum. METHODS: We analyzed 151 patients who underwent pacemaker implantation with a ventricular lead in the RVOT. Transthoracic echocardiographic (TTE) determination of pacing sites was applied in all patients after implantation...
March 25, 2018: Clinical Cardiology
Ting Wu, Xiangting Li, Tingting Li, Min Cai, Zhonghai Yu, Jingsi Zhang, Zhennian Zhang, Wen Zhang, Jun Xiang, Dingfang Cai
We investigated the effects of Apocynum venetum leaf extract (AVLE) on depressive behaviors and neuronal apoptosis in a chronic unpredictable mild stress (CUMS) rat model of depression. Rats were randomly divided into six groups: control, chronic unpredictable mild stress, fluoxetine, AVLE30, AVLE60, and AVLE120. Except for the control group, all rats were submitted to chronic unpredictable mild stress paradigms for four weeks to induce depressive behavior. Neuronal apoptosis was assessed by the terminal deoxynucleotidyl transferase- (TDT-) mediated dUTP-biotin nick end-labeling (TUNEL) method...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Ioannis L Oikonomidis, Christos Brozos, Evangelos Kiossis, Maria Kritsepi-Konstantinou
BACKGROUND: Clinical pathology investigations are essential to evaluate the health status and practice management of ruminants. Appropriate and accurate RIs are required for the interpretation of laboratory results. Despite substantial phenotypic differences and management-related disparities between male and female sheep, RIs in rams are sparse and limited by small reference populations and outdated methods. OBJECTIVES: The purpose of this study was to establish RIs for hematologic, biochemical, and hormonal analytes in adult rams using controlled preanalytic and analytic procedures, and to investigate whether breed-dependent partitioning of RIs is required...
March 2018: Veterinary Clinical Pathology
Xu Li, Jianwen Jiang
We report a density functional theory (DFT) study to investigate methanol-to-olefin (MTO) conversion in four types of ABC-6 zeolite cavities (cha, avl, aft and h1) by varying their shape and size. Based on a side-chain alkylation mechanism, the reaction energies and barriers of methylations, deprotonations and eliminations for hydrocarbon pool (HP) intermediates are calculated. In the cha cavity, methylations and eliminations are found to possess low barriers as attributed to the strong confinement effect of the elliptical and small cha cavity...
March 12, 2018: Physical Chemistry Chemical Physics: PCCP
Murat Sucu, Berzal Ucaman, Gökhan Altunbas
BACKGROUND: The coronary slow flow phenomenon (CSFP) is well-documented, and the early repolarization pattern (ERP) has recently been shown to be a risk factor for the development of malignant ventricular arrhythmias. METHODS: Those with true CSFP were included as cases and those with normal angiograms were included as controls. We assessed J-point elevation on surface electrocardiograms (ECGs) and defined ERP as notching or slurring of the terminal portion of the QRS takeoff...
February 20, 2018: Scandinavian Cardiovascular Journal: SCJ
Xiangting Li, Ting Wu, Zhonghai Yu, Tingting Li, Jingsi Zhang, Zhennian Zhang, Min Cai, Wen Zhang, Jun Xiang, Dingfang Cai
BACKGROUND: Major depressive disorder (MDD) is a common but serious psychiatric disorder, but current treatments are inadequate for approximately half of the patients with MDD. Thus, better methods of treatment are urgently needed. This study aimed to investigate the antidepressant-like effects and potential mechanism of Apocynum venetum leaf extract (AVLE) in chronic unpredictable mild stress (CUMS) rat model of depression. MATERIALS AND METHODS: The CUMS rat model of depression was used to investigate the antidepressant-like activity and relevant mechanism of AVLE (30, 60, and 125 mg/kg, i...
April 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Frantz Le Devedec, Hilary Boucher, David Dubins, Christine Allen
There is keen interest in the development of biocompatible and biodegradable implantable delivery systems (IDDS) that provide sustained drug release for prolonged periods in humans. These systems have the potential to enhance therapeutic outcomes, reduce systemic toxicity, and improve patient compliance. Herein, we report the preparation and physicochemical characterization of cross-linked polymeric matrices from poly(valerolactone)- co-poly(allyl-δ-valerolactone) (PVL- co-PAVL) copolymers for use in drug delivery...
April 2, 2018: Molecular Pharmaceutics
Edward I Patterson, Kelsey L Warmbrod, Donald H Bouyer, Naomi L Forrester
Working with virological samples requires validated inactivation protocols for safe handling and disposal. Although many techniques exist to inactivate samples containing viruses, not all procedures have been properly validated or are compatible with subsequent assays. To aid in the development of inactivation protocols for Alphaviruses, and specifically Venezuelan equine encephalitis virus (VEEV), a variety of methods were evaluated for their ability to completely inactivate a high titer sample of the vaccine strain VEEV TC-83...
April 2018: Journal of Virological Methods
David F Miranda, Angie S Lobo, Brooks Walsh, Yader Sandoval, Stephen W Smith
The 12-lead electrocardiogram (ECG) remains the most immediately accessible and widely used initial diagnostic tool for guiding management in patients with suspected myocardial infarction (MI). Although the development of high-sensitivity cardiac troponin assays has improved the rule-in and rule-out and risk stratification of acute MI without ST elevation, the immediate management of the subset of acute MI with acute coronary occlusion depends on integrating clinical presentation and ECG findings. Careful interpretation of the ECG might yield subtle features suggestive of ischemia that might facilitate more rapid triage of patients with subtle acute coronary occlusion or, conversely, in identification of ST-elevation MI mimics (pseudo ST-elevation MI patterns)...
February 2018: Canadian Journal of Cardiology
André B de Souza, Renan P S Rodrigues, Gerson T Pessoa, Andrezza Bs da Silva, Laecio S Moura, Francisco Ca Sousa, Elzivânia G da Silva, Anaemilia N Diniz, Maria Aps Barbosa, Jefferson R Araújo, Igor C Santos, Porfirio C Guerra, Jacyara Jrp Alves, Kássio V Macedo, Bruno Lm Diniz, Danielle C Marques, Flávio R Alves
Capuchin monkeys are a species of arboreal primate found in all South American countries. These monkeys have been highlighted for their potential for biomedical research due to their anatomic and physiologic similarities and genetic homology with humans. Here we characterized the electrocardiographic tracings from 12 healthy, young capuchin monkeys that were restrained with ketamine and midazolam. All 12 monkeys had normal sinus rhythms. Neither P-wave duration, PR interval, QT interval, nor P- or R-wave amplitude (in millivolts) differed between males and females...
January 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
Mert İlker Hayıroğlu, Muhammed Keskin, Ahmet Okan Uzun, Ceyhan Türkkan, Ahmet İlker Tekkeşin, Ömer Kozan
BACKGROUND: Electrical phenomenon and remote myocardial ischemia are the main factors of ST segment depression in inferior leads in acute anterior myocardial infarction (AAMI). We investigated the prognostic value of the sum of ST segment depression amplitudes in inferior leads in patients with first AAMI treated with primary percutaneous coronary intervention. (PPCI). METHODS: In this prospective analysis, we evaluated the in-hospital prognostic impact of the sum of ST segment depression in inferior leads on 206 patients with first AAMI...
December 12, 2017: Journal of Electrocardiology
Yuki Komatsu, Akihiko Nogami, Yasutoshi Shinoda, Keita Masuda, Takeshi Machino, Kenji Kuroki, Hiro Yamasaki, Yukio Sekiguchi, Kazutaka Aonuma
BACKGROUND: The communicating vein (CV) between the great cardiac vein and small cardiac venous systems passes between the aortic and pulmonary annulus and is located in close association with the left ventricular summit (summit CV). METHODS AND RESULTS: Thirty-one patients with idiopathic ventricular arrhythmias (VAs) underwent mapping of the left ventricular summit by using a 2F microcatheter introduced into the summit CV with coronary sinus venographic guidance...
January 2018: Circulation. Arrhythmia and Electrophysiology
Qiang Liu, Michael Shehata, David Z Lan, Ashkan Ehdaie, Eugenio Cingolani, Sumeet S Chugh, Guosheng Fu, Chenyang Jiang, Xunzhang Wang
BACKGROUND: There remains some confusion delineating the accurate location and the detailed anatomical relationship between atrioventricular accessory pathways (APs) located in the superoparaseptal region. OBJECTIVE: The purpose of this article was to detail the anatomical relationship and accurate location of APs located in the superoparaseptal region. METHODS: Between May 2009 and November 2016, 11 patients with superoparaseptal APs (SPS-APs) were identified in 129 consecutive patients who underwent catheter ablation for APs in our center...
December 24, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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