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https://www.readbyqxmd.com/read/28482065/use-of-bacillus-subtilis-pb6-as-a-potential-antibiotic-growth-promoter-replacement-in-improving-performance-of-broiler-birds
#1
Sathishkumar Jayaraman, Partha Pratim Das, Prakash Chandra Saini, Barun Roy, Paresh Nath Chatterjee
The intestinal gut health is one of the primary determinants of broiler growth and performance. Among the various enteric diseases, necrotic enteritis (NE) is an enterotoxemic disease caused by Clostridium perfringens, which can result in severe economic losses in poultry farming. Antibiotics like bacitracin methylene disalicylate (BMD) and avilamycin (AVL) are commonly used antibiotic growth promoters (AGP) in poultry feed to control necrotic enteritis in birds. Bacillus subtilis PB6 was reported to prevent necrotic enteritis and improve performance in birds...
May 6, 2017: Poultry Science
https://www.readbyqxmd.com/read/28452316/predictive-value-of-qt-dispersion-and-isolated-t-wave-inversion-in-lead-avl-for-early-detection-of-left-anterior-descending-coronary-artery-lesions
#2
Ramadan Ghaleb, Hossam Mansour
No abstract text is available yet for this article.
March 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/28436566/atrial-fibrillation-originating-from-superior-vena-cava-with-atrial-flutter-electrocardiogram-pattern
#3
Hung-Kai Huang, Shih-Lin Chang, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Yen-Chang Huang, Chung-Hsing Lin, Chao-Shun Chan, Hung-Yu Chang, Chin-Yu Lin, Yao-Ting Chang, Ching-Hui Huang, Shih-Ann Chen
BACKGROUNDS: Substrate property is related to the genesis and maintenance of atrial fibrillation (AF). The aim of the study was to investigate the impact of substrate property on the electrocardiogram (ECG) in patients with AF originating from the superior vena cava (SVC). METHODS AND RESULTS: Seventy-six patients with AF originating from SVC underwent catheter ablation were included from 2004 to 2013. Of these patients, 16 had a presentation of atrial flutter (AFL)-pattern ECG during AF (group 1), and 60 patients did not (group 2)...
April 24, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28430947/electrocardiographic-left-ventricular-hypertrophy-predicts-cardiovascular-morbidity-and-mortality-in-hypertensive-patients-the-allhat-study
#4
Casper N Bang, Elsayed Z Soliman, Lara M Simpson, Barry R Davis, Richard B Devereux, Peter M Okin
BACKGROUND: Electrocardiographic (ECG) left ventricular hypertrophy (LVH) is a strong predictor of cardiovascular (CV) morbidity and mortality. However, the predictive value of ECG LVH in treated hypertensive patients remains unclear. METHODS: A total of 33,357 patients (aged ≥ 55 years) with hypertension and at least 1 other coronary heart disease (CHD) risk factor were randomized to chlorthalidone, amlodipine, or lisinopril. The outcome of the present study was all-cause mortality; and secondary endpoints were CHD, nonfatal myocardial infarction (MI), stroke, angina, heart failure (HF), and peripheral arterial disease...
April 19, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28423167/what-pre-columbian-mummies-could-teach-us-about-south-american-leishmaniases
#5
REVIEW
Denis Sereno, Mohammad Akhoundi, Franck Dorkeld, Bruno Oury, Hooman Momen, Pascale Perrin
A recent report on the taxonomic profile of the human gut microbiome in pre-Columbian mummies (Santiago-Rodriguez et al. 2016) gives for the first time evidence of the presence of Leishmania DNA (sequences similar to Leishmania donovani according to the authors) that can be reminiscent of visceral leishmaniasis during the pre-Columbian era. It is commonly assumed that Leishmania infantum, the etiological agent of American visceral leishmaniasis (AVL) was introduced into the New World by the Iberian conquest...
April 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28414663/not-another-acs-rule-out
#6
S Preston, R Nelson, M Watts, D Smith, T Dewenter, D Spruill
CASE: A 50 year old African-American woman with diabetes, hypertension, and hyperlipidemia presented with progressively worsening retro-sternal chest pain, exacerbated by activity and relieved by rest. She also endorsed a thirty-pound unintentional weight loss, and dysphagia. She was dysarthric with left-sided Bell's Palsy and a palpable left axillary lymph node. She had been evaluated at several hospitals in the previous months for similar typical chest pain. Her troponin values were normal, and an EKG showed T-wave inversions in leads I and aVL...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28400921/validity-of-electrocardiographic-criteria-for-increased-left-ventricular-mass-in-young-patients-in-the-general-population
#7
Eduard Sklyar, Paul Ginelli, Aaron Barton, Richard Peralta, Jonathan N Bella
AIM: To investigate validity of electrocardiographic (ECG) criteria for left ventricular hypertrophy (LVH) in young adults. METHODS: Retrospectively, echocardiograms showing LVH and concomitant electrocardiograms were collected in patients 18 to 39 years old. A control group of patients without LVH was collected. Using echocardiogram as the gold standard, electrocardiograms were analyzed using common voltage criteria. RESULTS: Study included 100 subjects (52% male, mean age = 28 ± 6...
March 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28344026/the-impact-of-various-scaffold-components-on-vascularized-bone-constructs
#8
Ahmad Eweida, Matthias Schulte, Oliver Frisch, Ulrich Kneser, Leila Harhaus
Bone tissue engineering is gaining more interest in the field of craniofacial surgery where continuous efforts are being made to improve the outcomes via modulation of the scaffold components. In an in vitro three dimensional (3D) culture, the effect of bone morphogenic protein 2 (BMP2, 60 μg/ml) and the effect of different cell seeding densities (0.25, 0.5, and 1 × 104) of rat mesenchymal stem cells seeded on nanocrystalline hydroxyapatite in silica gel matrix (Nanobone(®)) on the cell viability and differentiation were studied...
February 24, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28343785/pericardial-mesothelioma-presenting-as-a-suspected-st-elevation-myocardial-infarction
#9
Ana Sofia Barroso, Sérgio Leite, Fernando Friões, Mariana Vasconcelos, Daniela Azevedo, Helena Baldaia, Mário Jorge Amorim, Paula Dias
Primary cardiac and pericardial tumors are rare entities with an autopsy frequency of 0.001-0.03%. Metastases to the heart and pericardium are much more common than primary tumors. Malignant pericardial mesotheliomas account for up to 50% of primary pericardial tumors. We report the case of a 75-year-old woman with hypertension, dyslipidemia and atrial fibrillation who went to the emergency department due to nonspecific thoracic discomfort of over six hours duration associated with syncope. Physical examination revealed a low-amplitude arrhythmic pulse, no heart murmurs and no signs of pulmonary congestion...
April 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28328081/btk-inhibition-is-a-potent-approach-to-block-ige-mediated-histamine-release-in-human-basophils
#10
D Smiljkovic, K Blatt, G Stefanzl, Y Dorofeeva, C Skrabs, M Focke-Tejkl, W R Sperr, U Jaeger, R Valenta, P Valent
BACKGROUND: Recent data suggest that Bruton's tyrosine kinase (BTK) is an emerging therapeutic target in IgE receptor (IgER)-cross-linked basophils. METHODS: We examined the effects of four BTK inhibitors (ibrutinib, dasatinib, AVL-292, and CNX-774) on IgE-dependent activation and histamine release in blood basophils obtained from allergic patients (n=11) and nonallergic donors (n=5). In addition, we examined the effects of these drugs on the growth of the human basophil cell line KU812 and the human mast cell line HMC-1...
March 22, 2017: Allergy
https://www.readbyqxmd.com/read/28315838/germline-proliferation-is-regulated-by-somatic-endocytic-genes-via-jnk-and-bmp-signaling-in-drosophila
#11
Yaning Tang, Qing Geng, Di Chen, Shaowei Zhao, Xian Liu, Zhaohui Wang
Signals derived from the microenvironment contribute greatly to tumorigenesis . The underlying mechanism requires thorough investigation. Here, we use Drosophila testis as a model system to address this question, taking the advantage of the ease to distinguish germline and somatic cells and to track the cell numbers. In an EMS mutagenesis screen, we identified Rab5, a key factor in endocytosis, for its nonautonomous role in germline proliferation. The disruption of Rab5 in somatic cyst cells, which escort the development of germline lineage, induced the overproliferation of underdifferentiated but genetically wild-type germ cells...
May 2017: Genetics
https://www.readbyqxmd.com/read/28314845/distribution-and-prognostic-significance-of-fragmented-qrs-in-patients-with-brugada-syndrome
#12
Hiroshi Morita, Atsuyuki Watanabe, Yoshimasa Morimoto, Satoshi Kawada, Motomi Tachibana, Koji Nakagawa, Nobuhiro Nishii, Hiroshi Ito
BACKGROUND: Fragmented QRS complexes (fQRS) in the right precordial leads are associated with occurrence of ventricular fibrillation (VF) in Brugada syndrome. Recently, epicardial mapping has revealed abnormal electrograms at the right ventricular (RV) outflow tract and inferior region of the right ventricle. fQRS may reflect the extent of the area of abnormal potentials, but whether the distribution of fQRS has prognostic value is not known. METHODS AND RESULTS: We evaluated the existence of fQRS in 456 patients with Brugada syndrome, including 117 patients with syncope and 23 patients with VF...
March 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28285712/the-value-of-reciprocal-electrocardiographic-leads
#13
Mazen M Kawji, David L Glancy
In a woman with chest pain, <0.1 mV ST-segment elevation in lead III, and virtually no ST elevation in leads II and aVF, striking ST-segment depression in lead aVL, the reciprocal lead to lead III, confirmed the diagnosis of acute inferior myocardial infarction.
May 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28244206/surface-ecg-and-fluoroscopy-are-not-predictive-of-right-ventricular-septal-lead-position-compared-to-cardiac-ct
#14
Matthew Rowe, Peter Moore, Jit Pratap, John Coucher, Paul Gould, Gerald Kaye
BACKGROUND: Controversy exists regarding the optimal lead position for chronic right ventricular (RV) pacing. Placing a lead at the RV septum relies upon fluoroscopy assisted by a surface 12-lead electrocardiogram (ECG). We compared the post-implant lead position determined by ECG-gated Multi-Detector contrast enhanced CT (MDCT) with the position derived from the surface 12 lead ECG. METHODS: Eighteen patients with permanent RV leads were prospectively enrolled...
February 28, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28196430/first-in-human-trial-of-a-type-i-positive-allosteric-modulator-of-alpha7-nicotinic-acetylcholine-receptors-pharmacokinetics-safety-and-evidence-for-neurocognitive-effect-of-avl-3288
#15
Kelvin W Gee, Ann Olincy, Richard Kanner, Lynn Johnson, Derk Hogenkamp, Josette Harris, Minhtam Tran, Stephen A Edmonds, William Sauer, Ryan Yoshimura, Timothy Johnstone, Robert Freedman
Type I positive allosteric modulators (PAMs) of the alpha7-nicotinic receptor enhance its cholinergic activation while preserving the spatiotemporal features of synaptic transmission and the receptor's characteristic rapid desensitization kinetics. Alpha7-nicotinic receptor agonists have shown promise for improving cognition in schizophrenia, but longer-term trials have been disappointing. Therefore, the type I PAM AVL-3288 was evaluated for safety and preliminary evidence of neurocognitive effect in healthy human subjects...
February 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28131622/perinatal-nicotine-treatment-induces-transient-increases-in-nacho-protein-levels-in-the-rat-frontal-cortex
#16
Franziska Wichern, Majbrit M Jensen, Ditte Z Christensen, Jens D Mikkelsen, Marjorie C Gondré-Lewis, Morten S Thomsen
The nicotinic acetylcholine receptor (nAChR) regulator chaperone (NACHO) was recently identified as an important regulator of nAChR maturation and surface expression. Here we show that NACHO levels decrease during early postnatal development in rats. This decrease occurs earlier and to a greater degree in the frontal cortex (FC) compared with the hippocampus (HIP). We further show that rats exposed to nicotine during pre- and postnatal development exhibit significantly higher NACHO levels in the FC at postnatal day (PND) 21, but not at PND60...
March 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/28107074/analysis-of-the-normal-electrocardiogram-in-wild-rooks-corvus-frugilegus
#17
Hossein Hassanpour, Hossein Abbasi Dehkordi, Mehdi Khosravi, Saeid Soltani, Leila Nasiri
To describe the normal electrocardiographic (ECG) patterns and values in unanesthetized rooks ( Corvus frugilegus ), standard bipolar (I, II, and III) and augmented unipolar limb (aVR, aVL, and aVF) lead ECGs were recorded from 10 clinically healthy wild rooks. Wave forms were analyzed in all leads at 50 mm/s and at 10 mm = 1 mV to determine PR, QRS, ST, and QT durations; the net QRS complex; and P and T amplitudes. The polarity of each waveform was tabulated in all leads. The mean electrical axis (MEA) for the frontal plane was counted by using leads II and III...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28050905/detailed-analysis-of-criteria-and-particle-emissions-from-a-very-large-crude-carrier-using-a-novel-eca-fuel
#18
Nicholas R Gysel, William A Welch, Kent Johnson, Wayne Miller, David R Cocker
Ocean going vessels (OGVs) operating within emission control areas (ECA) are required to use fuels with ≤0.1 wt % sulfur. Up to now only distillate fuels could meet the sulfur limits. Recently refiners created a novel low-sulfur heavy-fuel oil (LSHFO) meeting the sulfur limits so questions were posed whether nitric oxide (NOx) and particulate matter (PM) emissions were the same for the two fuels. This project characterized criteria pollutants and undertook a detailed analysis of PM emissions from a very large crude oil carrier (VLCC) using a distillate ECA fuel (MGO) and novel LSHFO...
February 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28041870/the-effect-of-nucleic-acid-extraction-platforms-and-sample-storage-on-the-integrity-of-viral-rna-for-use-in-whole-genome-sequencing
#19
Kuiama Lewandowski, Andrew Bell, Rory Miles, Simon Carne, David Wooldridge, Carmen Manso, Nicola Hennessy, Daniel Bailey, Steven T Pullan, Saheer Gharbia, Richard Vipond
Extraction of viral RNA and the storage of sample material are extremely important factors in the detection and whole genome sequencing (WGS) of viral pathogens. Although PCR-based detection methods focus on small amplicons, viral WGS applications require RNA of high quality and integrity for adequate sequence coverage and depth. This study examined the fitness of one manual and four automated RNA extraction platforms commonly used in diagnostic laboratories for use in metagenomic sequencing, how the practice of storing sample material in Qiagen buffer AVL before extraction affected the integrity of viral RNA and its suitability for use in amplicon-based WGS methods, and how the addition of Triton X-100 to buffer AVL affected the capability of the extraction platforms and the integrity of viral RNA in stored samples...
December 30, 2016: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28041756/trauma-induced-acute-myocardial-infarction-due-to-delayed-dissection-of-the-left-anterior-descending-coronary-artery
#20
Magdalena Wilczynska-Golonka, Pawel Rostoff, Aleksander Siniarski, Agnieszka Skrzypek, Andrzej Gackowski, Ewa Konduracka, Jadwiga Nessler
Acute myocardial infarction is a very rare, life-threatening complication of blunt chest trauma. A 27-year-old man with no previous medical history was admitted to the emergency department due to multiple trauma following a car accident. After 48h following the accident, the patient's condition rapidly deteriorated, with severe dyspnea at rest, tachycardia, and increasing chest pain. A 12-lead ECG showed a sinus tachycardia at 120bpm with significant ST-segment elevation in leads V1 to V5, pathologic Q wave in I, aVL, and QS complex in leads V1 to V4...
December 27, 2016: American Journal of Emergency Medicine
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