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https://www.readbyqxmd.com/read/29223976/zinc-detoxification-a-functional-genomics-and-transcriptomics-analysis-in-drosophila-melanogaster-cultured-cells
#1
Stephanie E Mohr, Kirstin Rudd, Yanhui Hu, Wei R Song, Quentin Gilly, Michael Buckner, Benjamin E Housden, Colleen Kelley, Jonathan Zirin, Rong Tao, Gabriel Amador, Katarzyna Sierzputowska, Aram Comjean, Norbert Perrimon
Cells require some metals, such as zinc and manganese, but excess levels of these metals can be toxic. As a result, cells have evolved complex mechanisms for maintaining metal homeostasis and surviving metal intoxication. Here, we present the results of a large-scale functional genomic screen in Drosophila cultured cells for modifiers of zinc chloride toxicity, together with transcriptomics data for wildtype or genetically zinc-sensitized cells challenged with mild zinc chloride supplementation. Altogether, we identified 47 genes for which knockdown conferred sensitivity or resistance to toxic zinc or manganese chloride treatment, and more than 1800 putative zinc-responsive genes...
December 9, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29223899/nighttime-nox-loss-and-clno2-formation-in-the-residual-layer-of-a-polluted-region-insights-from-field-measurements-and-an-iterative-box-model
#2
Hui Yun, Tao Wang, Weihao Wang, Yee Jun Tham, Qinyi Li, Zhe Wang, Steven C N Poon
The heterogeneous reaction of dinitrogen pentoxide (N2O5) on aerosols is an important sink of nitrogen oxides (NOx) in the polluted boundary layer, and the production of nitryl chloride (ClNO2) can have significant effects on the atmospheric oxidative capacity. However, the heterogeneous loss of N2O5 and the formation of ClNO2 are still not well quantified, especially in China. In a previous study, we measured ClNO2 and N2O5 concentrations in several air masses at a high-elevation site in Hong Kong, and found the highest levels ever reported at one night...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223896/environmental-status-of-livestock-and-poultry-sectors-in-china-under-current-transformation-stage
#3
Yi Qian, Kaihui Song, Tao Hu, Tianyu Ying
Intensive animal husbandry had aroused great environmental concerns in many developed countries. However, some developing countries are still undergoing the environmental pollution from livestock and poultry sectors. Driven by the large demand, China has experienced a remarkable increase in dairy and meat production, especially in the transformation stage from conventional household breeding to large-scale industrial breeding. At the same time, a large amount of manure from the livestock and poultry sector is released into waterbodies and soil, causing eutrophication and soil degradation...
December 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29223793/overexpression-of-g-protein-coupled-receptors-65-in-glioblastoma-predicts-poor-patient-prognosis
#4
Hong-Xiang Wang, Yi-Hong Chen, Jin-Xu Zhou, Xin-Yu Hu, Cong Tan, Yong Yan, Qi-Lin Huang, Jun-Yan Shen, Han-Chong Xu, Feng Li, Zhen-Yu Gong, Tao Xu, Ju-Xiang Chen
OBJECTIVE: G-protein-coupled receptors 65 (GPR65), identified as an acid-sensing receptor, is overexpressed in several malignancies and promote tumor development. Our aim was to investigate the expression and prognostic value of GPR65 in glioblastoma. MATERIALS AND METHODS: We determined the expression of GPR65 protein using immunohistochemistry in tissue microarrays containing 11 Grade I, 107 Grade II, 47 Grade III, and 102 Grade IV gliomas and 16 normal brains...
November 29, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29223647/tat-conjugated-chitosan-cationic-micelle-for-nuclear-targeted-drug-and-gene-co-delivery
#5
Guan-Hai Wang, Yin-Yu Cai, Ji-Kun Du, Li Li, Qin Li, Hui-Kang Yang, Jian-Tao Lin
We developed a high-efficiency nucleus-targeted co-delivery vector that delivers genes and drugs directly into the nucleus of cancer cells. The system is based on grafted poly-(N-3-carbobenzyloxy-lysine) (CPCL) with transactivator of transcription (TAT)- chitosan on the surface. It is designed to perform highly efficient nucleus- targeted gene and drug co-delivery. Confocal laser scanning microscopy (CLSM) revealed that more TAT-CPCL entered the nucleus than does CPCL alone. The TAT-modified vector serves as a gene and drug co-delivery mechanism to achieve high gene transfection efficiency, high apoptosis and low viability in HeLa cells...
December 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29223591/mild-hypothermia-protects-hippocampal-neurons-from-oxygen-glucose-deprivation-injury-through-inhibiting-caspase-3-activation
#6
Tianen Zhou, Hui Lin, Longyuan Jiang, Tao Yu, Chaotao Zeng, Juanhua Liu, Zhengfei Yang
Mild hypothermia (MH) is thought to be one of the most effective therapeutic methods to treat hypoxic-ischemic encephalopathy (HIE) after cardiac arrest (CA). However, its precise mechanisms remain unclear. In this research, hippocampal neurons were cultured and treated with mild hypothermia and Ac-DEVD-CHO after oxygen-glucose deprivation (OGD). The activity of caspase-3 was detected, in order to find the precise concentration of Ac-DEVD-CHO with the same protective role in OGD injury as MH treatment. Western blot and immunofluorescence staining were conducted to analyze the effects of MH and Ac-DEVD-CHO on the expressions of caspase-3, caspase-8, and PARP...
December 6, 2017: Cryobiology
https://www.readbyqxmd.com/read/29223397/-borneol-suppresses-conditioned-fear-recall-and-anxiety-like-behaviors-in-mice
#7
Bo Cao, Huan-Yu Ni, Jun Li, Ying Zhou, Xin-Lan Bian, Yan Tao, Cheng-Yun Cai, Cheng Qin, Hai-Yin Wu, Lei Chang, Chun-Xia Luo, Dong-Ya Zhu
Fear- and anxiety-related psychiatric disorders have been one of the major chronic diseases afflicting patients for decades, and new compounds for treating such disorders remain to be developed. (+)-Borneol, a bicyclic monoterpene found in several species of Artemisia and Dipterocarpaceae, is widely used for anxiety, pain and anesthesia in Chinese medicine. Meanwhile, it can potentiate GABA (γ-aminobutyric acid) activity directly in recombinant GABAA receptors. The present study was to investigate the effects of (+)-Borneol on both contextual and cued fear recall...
December 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29223358/genome-wide-mining-of-perfect-microsatellites-and-tetranucleotide-orthologous-microsatellites-estimates-in-six-primate-species
#8
Yongtao Xu, Wujiao Li, Zongxiu Hu, Tao Zeng, Yongmei Shen, Sanxu Liu, Xiuyue Zhang, Jing Li, Bisong Yue
Advancement in genome sequencing and in silico mining tools have provided new opportunities for comparative primate genomics of microsatellites. The SSRs (simple sequence repeats) numbers were not correlated with the genome size (Pearson, r=0.310, p=0.550), and were positively correlated with the total length of SSRs (Pearson, r=0.992, p=0.00). A total of 224,289 tetranucleotide orthologous microsatellites families and 367 single-copy orthologous SSRs loci were found in six primate species by homologous alignment...
December 6, 2017: Gene
https://www.readbyqxmd.com/read/29223330/expression-of-a-populus-histone-deacetylase-gene-84khda903-in-tobacco-enhances-drought-tolerance
#9
Xujun Ma, Bing Zhang, Chunjuan Liu, Botong Tong, Tao Guan, Dean Xia
Histone deacetylases (HDACs) play a key role in regulating plant growth, development and stress responses. However, functions of HDACs in woody plants are largely unknown. In this study, a novel gene encoding a RPD3/HDA1-type histone deacetylase was cloned from 84K poplar (Populus alba×Populus glandulosa) and designated as 84KHDA903. The 84KHDA903 encodes a protein composed of 500 amino acid residues, which contains a conserved HDAC domain. Transient expression of 84KHDA903 in onion epidermal cells suggested that it was exclusively localized in nucleus...
December 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29223171/caregiver-burden-sleep-quality-depression-and-anxiety-in-dementia-caregivers-a-comparison-of-frontotemporal-lobar-degeneration-dementia-with-lewy-bodies-and-alzheimer-s-disease
#10
Shuai Liu, Jing Liu, Xiao-Dan Wang, Zhihong Shi, Yuying Zhou, Jing Li, Tao Yu, Yong Ji
BACKGROUND: Very few recent studies are available that compare caregiver burden, sleep quality, and stress in caregivers of different types of dementia. We aimed to investigate caregiver burden, sleep quality, and stress in caregivers of patients with frontotemporal lobar degeneration and dementia with Lewy bodies, as compared with caregivers of patients with Alzheimer's disease. METHODS: This study was carried out from March 2011 to January 2014. In total, 492 dyads of patient and caregiver (frontotemporal lobar degeneration, n = 131; dementia with Lewy bodies, n = 36; Alzheimer's disease, n = 325) participated in this study...
December 10, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29223095/high-solid-anaerobic-digestion-of-corn-straw-for-methane-production-and-pretreatment-of-bio-briquette
#11
Yeqing Li, Fang Yan, Tao Li, Ying Zhou, Hao Jiang, Mingyu Qian, Quan Xu
In this study, an integrated process was developed to produce methane and high-quality bio-briquette (BB) using corn straw (CS) through high-solid anaerobic digestion (HS-AD). CS was anaerobic digested by using a leach bed reactor at four leachate recirculation strategies. After digesting for 28 days, highest methane yield of 179.6 mL/g-VS, which was corresponded to energy production of 5.55 MJ/kg-CS, was obtained at a higher initial recirculation rate of 32 L-leachate per day. Compared with bio-briquette manufactured from raw CS and lignite, the compressive, immersion and falling strength properties of bio-briquette made from AD-treated CS (solid digestate) and lignite were significantly improved...
November 28, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29222971/the-divergent-impact-of-catechol-o-methyltransferase-comt-val158met-genetic-polymorphisms-on-executive-function-in-adolescents-with-discrete-patterns-of-childhood-adversity
#12
Huihui Zhang, Jie Li, Bei Yang, Tao Ji, Zhouting Long, Qiquan Xing, Di Shao, Huayu Bai, Jiwei Sun, Fenglin Cao
PURPOSE: Catechol-O-methyltransferase (COMT) Val158Met functional polymorphisms play a crucial role in the development of executive function (EF), but their effect may be moderated by environmental factors such as childhood adversity. The present study aimed at testing the divergent impact of the COMT Val158Met genotype on EF in non-clinical adolescents with discrete patterns of childhood adversity. METHODS: A total of 341 participants completed the Childhood Trauma Questionnaire, the self-reported version of the Behavior Rating Inventory of Executive Function, and self-administered questionnaires on familial function...
November 22, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29222835/effective-network-of-deep-brain-stimulation-of-subthalamic-nucleus-with-bimodal-positron-emission-tomography-functional-magnetic-resonance-imaging-in-parkinson-s-disease
#13
Hui-Min Chen, Zhi-Qiang Sha, Hui-Zi Ma, Yong He, Tao Feng
AIMS: Deep brain stimulation of the subthalamic nucleus (STN-DBS) has become an effective treatment strategy for patients with Parkinson's disease. However, the biological mechanism underlying DBS treatment remains poorly understood. METHOD: In this study, we investigated how STN-DBS modulated the brain network using a bimodal positron emission tomography (PET)/functional magnetic resonance imaging (fMRI) dataset. We first performed an activation likelihood estimation meta-analysis of 13 PET/SPECT studies concerning STN-DBS effects on resting-state brain activity in Parkinson's disease...
December 8, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29222745/mir-26a-functions-as-a-tumor-suppressor-in-ambient-particulate-matter-bound-metal-triggered-lung-cancer-cell-metastasis-by-targeting-lin28b-il6-stat3-axis
#14
Yan-Yang Lu, Yi Lin, Dong-Xiao Ding, Shu Su, Qiao-Qiao Chi, You-Chi Zhang, Jian Sun, Xu Zhang, Hui-Min Zhu, Qian-Sheng Huang, Yu-Lang Chi, Guo-Zhu Ye, Shu Tao, Si-Jun Dong
Exposure to ambient particulate matter (PM) has been linked to the increasing incidence and mortality of lung cancer, but the principal toxic components and molecular mechanism remain to be further elucidated. In this study, human lung adenocarcinoma A549 cells were treated with serial concentrations of water-extracted PM10 (WE-PM10) collected from Beijing, China. Our results showed that exposure to 25 and 50 μg/ml of WE-PM10 for 48 h significantly suppressed miR-26a to upregulate lin-28 homolog B (LIN28B), and in turn activated interleukin 6 (IL6) and signal transducer and activator of transcription 3 (STAT3) in A549 cells, subsequently contributing to enhanced epithelial-mesenchymal transition and accelerated migration and invasion...
December 8, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29222676/intravoxel-incoherent-motion-mr-imaging-of-early-cervical-carcinoma-correlation-between-imaging-parameters-and-tumor-stroma-ratio
#15
Xiangsheng Li, Ping Wang, Dechang Li, Hongxian Zhu, Limin Meng, Yunlong Song, Lizhi Xie, Jianping Zhu, Tao Yu
OBJECTIVES: To investigate if intravoxel incoherent motion (IVIM) MR imaging can predict the tumour-stroma ratio (TSR) in patients with early cervical carcinoma. METHODS: Fifty-four patients with early cervical carcinoma were prospectively enrolled into this study. All patients underwent IVIM imaging and parameters including D, D* and f value were measured. The tumours were classified into stroma-rich and stroma-poor group according to TSR, and comparisons of IVIM parameters between two groups were performed...
December 8, 2017: European Radiology
https://www.readbyqxmd.com/read/29222654/determination-of-total-phthalate-in-cosmetics-using-a-simple-three-phase-sample-preparation-method
#16
Laping Liu, Zhengmeng Wang, Sihan Zhao, Jiahui Duan, Hu Tao, Wenji Wang, Shuhui Liu
A simple sample preparation method requiring minimal organic solvents is proposed for the determination of the total phthalate content in cosmetics by high-performance liquid chromatography-tandem mass spectrometry. The hydrolysis of phthalates and purification of interfering substances were performed in a three-phase system that included an upper n-hexane phase, a middle ethanol phase, and a lower aqueous alkali solution. This three-phase system utilized an incremental purification strategy. The apolar ingredients were extracted with n-hexane, the polar pigments accumulated in the ethanol phase, and the hydrolysis product, phthalic acid, remained in the hydrolysate...
December 9, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29222476/morphophysiological-mechanism-of-rice-yield-increase-in-response-to-optimized-nitrogen-management
#17
Wei Zhou, Tengfei Lv, Zhiping Yang, Tao Wang, Yong Fu, Yong Chen, Binhua Hu, Wanjun Ren
The yield-increasing mechanism of an optimized nitrogen fertilizer application (OFA) in rice was reported in this work through a three-year test. Results showed that the number of branches and spikelets increased, panicle length, the diameter and vascular bundle number of panicle-neck internode improved with OFA. Under the condition of OFA, high effective leaf areas, especially for the flag and the second upper leaf areas, increased, the net photosynthetic rate of the upper three leaves promoted, so the photosynthetic productivity went up by a large margin; moreover, the content of soluble protein and chlorophyll of leaf also increased, and the content of soluble sugar and malondialdehyde (MDA) decreased, as a result in slowing down the senescence speed in leaves, and increasing the photosynthetic time...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222134/workplace-violence-psychological-stress-sleep-quality-and-subjective-health-in-chinese-doctors-a-large-cross-sectional-study
#18
Tao Sun, Lei Gao, Fujun Li, Yu Shi, Fengzhe Xie, Jinghui Wang, Shuo Wang, Shue Zhang, Wenhui Liu, Xiaojian Duan, Xinyan Liu, Zhong Zhang, Li Li, Lihua Fan
BACKGROUND: Workplace violence (WPV) against healthcare workers is known as violence in healthcare settings and referring to the violent acts that are directed towards doctors, nurses or other healthcare staff at work or on duty. Moreover, WPV can cause a large number of adverse outcomes. However, there is not enough evidence to test the link between exposure to WPV against doctors, psychological stress, sleep quality and health status in China. OBJECTIVES: This study had three objectives: (1) to identify the incidence rate of WPV against doctors under a new classification, (2) to examine the association between exposure to WPV, psychological stress, sleep quality and subjective health of Chinese doctors and (3) to verify the partial mediating role of psychological stress...
December 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/29222050/effects-of-the-rna-binding-protein-ksrp-on-innate-immune-response-against-helicobacter-pylori-infection-in-mice
#19
Ningzhe Li, Mei Cao, Sijun Yi, Juan Cheng, Lei Wang, Yuwei Tao, Daoyan Wu, Jingshan Peng, Mao Zhang, Panpan Qi, Jian Zhao
Helicobacter pylori (H. pylori) contributes to various gastric diseases such as chronic gastritis, gastric ulcer, and gastric carcinoma. Host innate immune response against the pathogen plays a significant role in elimination of pathogen infection. Importantly, pathogen elimination is closely related to numerous inflammatory-related genes that participate in complex biological response of cells to harmful stimuli. Here we studied effects of the KH-type splicing regulatory protein (KSRP), a RNA-binding protein, on innate immune response against H...
December 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29222025/preparation-and-comparison-of-tacrolimus-loaded-solid-dispersion-and-self-microemulsifying-drug-delivery-system-by-in-vitro-in-vivo-evaluation
#20
Taotao Huo, Chun Tao, Minxin Zhang, Qinghong Liu, Bing Lin, Zhihong Liu, Jialiang Zhang, Meijing Zhang, Haiyue Yang, Jue Wu, Xinrong Sun, Qian Zhang, Hongtao Song
This study aimed to compare the dissolution and the intestinal absorption of tacrolimus in self-microemulsifying drug delivery system (SMEDDS) and solid dispersion (SD). Poloxamer 188 SD was prepared by the combination of the solvent evaporation method and the freeze drying method. Hydroxypropyl methylcellulose (HPMC) SD was prepared by the solvent evaporation method combined with the vacuum drying method. The formation of SD was confirmed by SEM images which showed new solid phases. The SMEDDS was composed of oil (Labrafil M1944 CS 28%), surfactant (Cremophor EL 48%) and co-surfactant (Transcutol P 24%)...
December 5, 2017: European Journal of Pharmaceutical Sciences
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