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S S Chung, J S Zheng, S R Burket, B W Brooks
Though antibiotic resistance (ABR) represents a major global health threat, contributions of landfill leachate to the life cycle of antibiotics and ABR development are poorly understood in rapidly urbanizing regions of developing countries. We selected one of the largest active landfills in Asia and two landfills that have been closed for 20 years to examine antibiotic occurrences in leachates and associated hazards during wet and dry season sampling events. We focused on some of the most commonly used human antibiotics in Hong Kong, one of the most populous Asian cities and the fourth most densely populated cities in the world...
March 15, 2018: Environment International
Nitin Telang
Mutations in the adenomatous polyposis coli (Apc) tumor suppressor gene represent the primary genetic defect in colon carcinogenesis. Apc+/- mouse models exhibit pre-invasive small intestinal adenomas. Cell culture models exhibiting Apc defects in the colon and quantifiable cancer risk provide a novel clinically relevant approach. The tumor-derived Apc-/- colonic epithelial cell line 1638N COL-Pr1 represented the experimental model. The anti-inflammatory drugs sulindac (SUL) and celecoxib (CLX) represented the test compounds...
January 2018: Oncology Letters
M Matbou Riahi, A Sahebkar, K Sadri, S Nikoofal-Sahlabadi, M R Jaafari
Celecoxib (CLX) is a selective COX-2 inhibitor with anticancer potential in a COX-2 dependent and independent manner. CLX's low water solubility has a dose limiting effect on its utilization in cancer treatment. Here, we developed liposomal drug delivery systems to allow a systemic administration and increase tumor accumulation of CLX based on the enhanced permeability and retention (EPR) mechanism. Nine liposomal formulations has been prepared with different phospholipid compositions; among them three sets of liposomal formulations were selected based on characterization and stability for further studies...
January 22, 2018: International Journal of Pharmaceutics
Anthony J Burand, Lauren Boland, Alex J Brown, James A Ankrum
Objective: Techniques to validate successful delivery of cell products are expensive, time-consuming, and require transport of the animal to imaging facilities, preventing their widespread use as documentation tools. The goal of this study was to determine if a low-cost portable microscope could provide sufficient performance to be used to document delivery of cell products and track retention over time. Approach: A Dino-Lite fluorescence microscope and an Odyssey CLx whole-animal scanner were compared on the basis of resolution, sensitivity, and linearity...
December 1, 2017: Advances in Wound Care
Arpita Varadwaj, Pradeep R Varadwaj, Koichi Yamashita
A relationship between reported experimental band gaps (solid) and DFT-calculated binding energies (gas) is established, for the first time, for each of the four ten-membered lead (or tin) trihalide perovskite solar cell semiconductor series examined in this study, including CH3 NH3 PbY3 , CsPbY3 , CH3 NH3 SnY3 and CsSnY3 (Y=I(3-x) Brx=1-3 , I(3-x) Clx=1-3 , Br(3-x) Clx=1-3 , and IBrCl). The relationship unequivocally provides a new dimension for the fundamental understanding of the optoelectronic features of solid-state solar cell thin films by using the 0 K gas-phase energetics of the corresponding molecular building blocks...
January 23, 2018: ChemSusChem
Yothin Teethaisong, Thippawan Pimchan, Rungrudee Srisawat, Glyn Hobbs, Griangsak Eumkeb
OBJECTIVE: The purpose of this study was to investigate the effect of Boesenbergia rotunda (L.) Mansf. Extract (BRE) and peptidoglycan inhibitor antibiotics, either used alone or in combination against β-lactam resistant Staphylococci. METHODS: Antibacterial and synergistic activities of BRE alone and in combination with ampicillin (AMP), cloxacillin (CLX), cefazolin (CFZ) or vancomycin (VAN) were evaluated against two β-lactam-resistant Staphylococcus aureus (BRSA) and one β-lactam-resistant Staphylococcus epidermidis (BRSE)...
November 1, 2017: Journal of Global Antimicrobial Resistance
Mohammad Amjadi, Roghayeh Jalili
We report on a ratiometric fluorescent sensor based on dual-emission molecularly imprinted mesoporous silica embedded with carbon dots and CdTe quantum dots (mMIP@CDs/QDs) for celecoxib (CLX) as target molecule. The fluorescence of the embedded CDs is insensitive to the analyte while the green emissive QDs are selectively quenched by it. This effect is much stronger for the MIP than for the non-imprinted polymer, which indicates a good recognition ability of the mesoporous MIP. The hybrid sensor also exhibited good selectivity to CLX over other substances...
October 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Koushik Saha, Rongala Ramalakshmi, Rosmita Borthakur, Suman Gomosta, Kriti Pathak, Vincent Dorcet, Thierry Roisnel, Jean-François Halet, Sundargopal Ghosh
In a quest for efficient precursors for the synthesis of boratrane complexes of late transition metals, we have developed a useful synthetic method using [L'M(μ-Cl)Clx ]2 as precursors (L'=η6 -p-cymene, M=Ru, x=1; L'=COD, M=Rh, x=0 and L'=Cp*, M=Ir or Rh, x=1; COD=1,5-cyclooctadiene, Cp*=η5 -C5 Me5 ). For example, treatment of Na[(H3 B)bbza] or Na[(H2 B)mp2 ] (bbza=bis(benzothiazol-2-yl)amine; mp=2-mercaptopyridyl) with [L'M(μ-Cl)Clx ]2 yielded [(η6 -p-cymene)RuBH{(NCSC6 H4 )(NR)}2 ] (2; R=NCSC6 H4 ), [{N(NCSC6 H4 )2 }RhBH{(NCSC6 H4 )(NR)}2 ] (3; R=NCS-C6 H4 ), [(η6 -p-cymene)RuBH(L)2 ] (5; L=C5 H4 NS), and [Cp*MBH(L)2 ] (6 and 7; L=C5 H4 NS, M=Ir or Rh)...
December 22, 2017: Chemistry: a European Journal
Cheng Li, Antonio Guerrero, Yu Zhong, Anna Gräser, Carlos Andres Melo Luna, Jürgen Köhler, Juan Bisquert, Richard Hildner, Sven Huettner
Organic-inorganic metal halide perovskites (e.g., CH3 NH3 PbI3-x Clx ) emerge as a promising optoelectronic material. However, the Shockley-Queisser limit for the power conversion efficiency (PCE) of perovskite-based photovoltaic devices is still not reached. Nonradiative recombination pathways may play a significant role and appear as photoluminescence (PL) inactive (or dark) areas on perovskite films. Although these observations are related to the presence of ions/defects, the underlying fundamental physics and detailed microscopic processes, concerning trap/defect status, ion migration, etc...
September 25, 2017: Small
F B Wiggers, Y Yamada-Takamura, A Y Kovalgin, M P de Jong
Silicene and other two-dimensional materials, such as germanene and stanene, have chemically reactive surfaces and are prone to oxidation in air, and thus require an encapsulation layer for ex situ studies or integration in an electronic device. In this work, we investigated NaCl as an encapsulation material for silicene. NaCl was deposited on the surface of epitaxial silicene on ZrB2(0001) thin films near room temperature and studied using synchrotron-based high-resolution photoelectron spectroscopy. The deposition of NaCl resulted in dissociative chemisorption, where the majority of epitaxial silicene reacted to form Si-Clx species...
August 14, 2017: Journal of Chemical Physics
James E Bishop, David K Mohamad, Michael Wong-Stringer, Alex Smith, David G Lidzey
We utilise spray-coating under ambient conditions to sequentially deposit compact-TiO2, mesoporous-TiO2, CH3NH3PbI(3-x)Clx perovskite and doped spiro-OMeTAD layers, creating a mesoporous standard architecture perovskite solar cell (PSC). The devices created had an average power conversion efficiency (PCE) of 9.2% and a peak PCE of 10.2%; values that compare favourably with control-devices fabricated by spin-casting that had an average efficiency of 11.4%. We show that our process can be used to create devices having an active-area of 1...
August 11, 2017: Scientific Reports
Wenjing Song, Yun Tang, Jing Qiao, Haili Li, Bei Rong, Songlin Yang, Yuan Wu, Xiaoming Yan
PURPOSE: To investigate, after 24 h, the safety of genipin or ultraviolet A (UVA)-riboflavin crosslinking of keratocytes and endothelial cells. METHODS: Fifteen New Zealand white rabbits were selected and divided into a PBS group (five rabbits), a 0.2% genipin crosslinking (GP-CXL) group (five rabbits), and a UVA-riboflavin crosslinking (UVA-CXL) group (five rabbits). In the GP-CXL and PBS groups, 0.2% genipin or PBS was applied to the corneal surface of the right eyes...
2017: Molecular Vision
Jinqiang Zhang, Bing Sun, Yufei Zhao, Katja Kretschmer, Guoxiu Wang
Large over-potentials owing to the sluggish kinetics of battery reactions have always been the drawbacks of Li-O2 batteries, which lead to short cycle life. Although redox mediators have been intensively investigated to overcome this issue, side-reactions are generally induced by the solvated nature of redox mediators. Herein, we report an alternative method to achieve more efficient utilization of tetrathiafulvalene (TTF) in Li-O2 batteries. By coordinating TTF(+) with LiCl during charging, an organic conductor TTF(+) Clx(-) precipitate covers Li2 O2 to provide an additional electron-transfer pathway on the surface, which can significantly reduce the charge over-potential, improve the energy efficiency of Li-O2 batteries, and eliminate side-reactions between the lithium metal anode and TTF(+) ...
May 23, 2017: Angewandte Chemie
Mohamed A Heikal, Tarek Tawfik Soliman, Ayser Fayed, Abdelmonem M Hamed
PURPOSE: To evaluate the efficacy of transepithelial corneal collagen crosslinking (TE-CXL) in patients with progressive keratoconus. PATIENTS AND METHODS: This is a prospective interventional consecutive study carried out on 30 eyes of 18 patients with progressive keratoconus who underwent TE-CLX using both ParaCel™ (riboflavin 0.25%, hydroxy propyl methyl cellulose, NaCl, ethylenediaminetetraacetic acid [EDTA], Tris, and benzalkonium chloride) and vibeX-Xtra (riboflavin 0...
2017: Clinical Ophthalmology
Gordon C C Yang, Pei-Ling Tang, Chia-Heng Yen
In this work the optimal operating conditions for removing selected micropollutants (also known as emerging contaminants, ECs) from actual municipal wastewater by graphene adsorption (GA) and simultaneous electrocoagulation/electrofiltration (EC/EF) process, respectively, were first determined and evaluated. Then, performance and mechanisms for the removal of selected phthalates and pharmaceuticals from municipal wastewater simultaneously by the GA and EC/EF process were further assessed. ECs of concern included di-n-butyl phthalate (DnBP), di-(2-ethylhexyl) phthalate (DEHP), acetaminophen (ACE), caffeine (CAF), cefalexin (CLX) and sulfamethoxazole (SMX)...
April 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Seyed Jalal Hosseinimehr, Mahdieh Fathi, Arash Ghasemi, Seyedeh Nesa Rezaeian Shiadeh, Tayyeb Allahverdi Pourfallah
Ionizing radiation causes DNA damage and chromosome abbreviations on normal cells. The radioprotective effect of celecoxib (CLX) was investigated against genotoxicity induced by ionizing radiation in cultured human blood lymphocytes. Peripheral blood samples were collected from human volunteers and were incubated at different concentrations at 1, 5, 10 and 50 μM of CLX for two hours. At each dose point, the whole blood was exposed in vitro to 150 cGy of X-ray, and then the lymphocytes were cultured with mitogenic stimulation to determine the micronucleus frequency in cytokinesis blocked binucleated lymphocytes...
February 2017: Research in Pharmaceutical Sciences
Harry M Cronin, K D G Imalka Jayawardena, Zlatka Stoeva, Maxim Shkunov, S Ravi P Silva
Mixed halide Perovskite solar cells (PSCs) are commonly produced by depositing PbCl2 and CH3NH3I from a common solvent followed by thermal annealing, which in an up-scaled manufacturing process is likely to take place under ambient conditions. However, it has been reported that, similar to the effects of thermal annealing, ambient humidity also affects the crystallisation behaviour and subsequent growth of the Perovskite films. This implies that both of these factors must be accounted for in solar cell production...
January 25, 2017: Nanotechnology
Amir Blazevic, Alfred A Hummer, Petra Heffeter, Walter Berger, Martin Filipits, Giannantonio Cibin, Bernhard K Keppler, Annette Rompel
Ruthenium complexes are promising candidates for anticancer agents, especially NKP-1339 (sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)]), which is on the edge to clinical applications. The anticancer mechanism seems to be tightly linked to the redox chemistry but despite progress in human clinical trials the in vivo Ru oxidation state and the coordination of Ru remains unclear. The Ru-based anticancer drug NKP-1339 was studied applying XANES (Cl K- and Ru L2,3-edges) in tumor, kidney and liver tissue of a SW480 bearing mouse...
January 23, 2017: Scientific Reports
Valeria Ambrogi, Donatella Pietrella, Morena Nocchetti, Serena Casagrande, Veronica Moretti, Stefania De Marco, Maurizio Ricci
HYPOTHESIS: Chlorhexidine (CLX) is a good antimicrobial agent, but its use in treatment of wounds is limited because of its cytotoxicity towards human fibroblasts. A delivery system, able to release CLX in a localized and prolonged manner, could guarantee antimicrobial activity with reduced cytotoxic. Thus in this work the preparation and characterization of chitosan/montmorillonite composite films containing CLX, able to offer a prolonged CLX release, is described. The antimicrobial and antibiofilm activities and cytotoxicity of films were investigated...
April 1, 2017: Journal of Colloid and Interface Science
Manoela Siqueira Pimenta, Nayana Santiago Guedis Lobo, Virna Castelo Vieira, Ângela Maria Alves da Costa, Flávio Nogueira da Costa, Sérgio Luís da Silva Pereira
The aim of this study was to evaluate the antiplaque effect of Ocimum gratissimum (Og) by in vivo investigation. Fifteen healthy volunteers participated in a crossover, double-blind clinical study, using a 3-day partial-mouth plaque accumulation model. The participants abolished any method of mechanical oral hygiene and they were randomly assigned to initially use just the following mouthrinses: distilled water (DW solution), 0.12% chlorhexidine digluconate (CLX solution) or 10% Og (Og solution). The plaque index (PLI) was recorded in all mandibular teeth at the end of the trial and the Kruskal-Wallis (α=0...
October 2016: Brazilian Dental Journal
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