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Jinqiang Zhang, Bing Sun, Yufei Zhao, Katja Kretschmer, Guoxiu Wang
Large over-potentials owing to the sluggish kinetics of battery reactions have always been the drawbacks of Li-O2 batteries, which lead to short cycle life. Although redox mediators have been intensively investigated to overcome this issue, side-reactions are generally induced by the solvated nature of redox mediators. Herein, we report an alternative method to achieve more efficient utilization of tetrathiafulvalene (TTF) in Li-O2 batteries. By coordinating TTF(+) with LiCl during charging, an organic conductor TTF(+) Clx(-) precipitate covers Li2 O2 to provide an additional electron-transfer pathway on the surface, which can significantly reduce the charge over-potential, improve the energy efficiency of Li-O2 batteries, and eliminate side-reactions between the lithium metal anode and TTF(+) ...
May 23, 2017: Angewandte Chemie
Mohamed A Heikal, Tarek Tawfik Soliman, Ayser Fayed, Abdelmonem M Hamed
PURPOSE: To evaluate the efficacy of transepithelial corneal collagen crosslinking (TE-CXL) in patients with progressive keratoconus. PATIENTS AND METHODS: This is a prospective interventional consecutive study carried out on 30 eyes of 18 patients with progressive keratoconus who underwent TE-CLX using both ParaCel™ (riboflavin 0.25%, hydroxy propyl methyl cellulose, NaCl, ethylenediaminetetraacetic acid [EDTA], Tris, and benzalkonium chloride) and vibeX-Xtra (riboflavin 0...
2017: Clinical Ophthalmology
Gordon C C Yang, Pei-Ling Tang, Chia-Heng Yen
In this work the optimal operating conditions for removing selected micropollutants (also known as emerging contaminants, ECs) from actual municipal wastewater by graphene adsorption (GA) and simultaneous electrocoagulation/electrofiltration (EC/EF) process, respectively, were first determined and evaluated. Then, performance and mechanisms for the removal of selected phthalates and pharmaceuticals from municipal wastewater simultaneously by the GA and EC/EF process were further assessed. ECs of concern included di-n-butyl phthalate (DnBP), di-(2-ethylhexyl) phthalate (DEHP), acetaminophen (ACE), caffeine (CAF), cefalexin (CLX) and sulfamethoxazole (SMX)...
April 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Seyed Jalal Hosseinimehr, Mahdieh Fathi, Arash Ghasemi, Seyedeh Nesa Rezaeian Shiadeh, Tayyeb Allahverdi Pourfallah
Ionizing radiation causes DNA damage and chromosome abbreviations on normal cells. The radioprotective effect of celecoxib (CLX) was investigated against genotoxicity induced by ionizing radiation in cultured human blood lymphocytes. Peripheral blood samples were collected from human volunteers and were incubated at different concentrations at 1, 5, 10 and 50 μM of CLX for two hours. At each dose point, the whole blood was exposed in vitro to 150 cGy of X-ray, and then the lymphocytes were cultured with mitogenic stimulation to determine the micronucleus frequency in cytokinesis blocked binucleated lymphocytes...
February 2017: Research in Pharmaceutical Sciences
Harry M Cronin, K D G Imalka Jayawardena, Zlatka Stoeva, Maxim Shkunov, S Ravi P Silva
Mixed halide Perovskite solar cells (PSCs) are commonly produced by depositing PbCl2 and CH3NH3I from a common solvent followed by thermal annealing, which in an up-scaled manufacturing process is likely to take place under ambient conditions. However, it has been reported that, similar to the effects of thermal annealing, ambient humidity also affects the crystallisation behaviour and subsequent growth of the Perovskite films. This implies that both of these factors must be accounted for in solar cell production...
January 25, 2017: Nanotechnology
Amir Blazevic, Alfred A Hummer, Petra Heffeter, Walter Berger, Martin Filipits, Giannantonio Cibin, Bernhard K Keppler, Annette Rompel
Ruthenium complexes are promising candidates for anticancer agents, especially NKP-1339 (sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)]), which is on the edge to clinical applications. The anticancer mechanism seems to be tightly linked to the redox chemistry but despite progress in human clinical trials the in vivo Ru oxidation state and the coordination of Ru remains unclear. The Ru-based anticancer drug NKP-1339 was studied applying XANES (Cl K- and Ru L2,3-edges) in tumor, kidney and liver tissue of a SW480 bearing mouse...
January 23, 2017: Scientific Reports
Valeria Ambrogi, Donatella Pietrella, Morena Nocchetti, Serena Casagrande, Veronica Moretti, Stefania De Marco, Maurizio Ricci
HYPOTHESIS: Chlorhexidine (CLX) is a good antimicrobial agent, but its use in treatment of wounds is limited because of its cytotoxicity towards human fibroblasts. A delivery system, able to release CLX in a localized and prolonged manner, could guarantee antimicrobial activity with reduced cytotoxic. Thus in this work the preparation and characterization of chitosan/montmorillonite composite films containing CLX, able to offer a prolonged CLX release, is described. The antimicrobial and antibiofilm activities and cytotoxicity of films were investigated...
April 1, 2017: Journal of Colloid and Interface Science
Manoela Siqueira Pimenta, Nayana Santiago Guedis Lobo, Virna Castelo Vieira, Ângela Maria Alves da Costa, Flávio Nogueira da Costa, Sérgio Luís da Silva Pereira
The aim of this study was to evaluate the antiplaque effect of Ocimum gratissimum (Og) by in vivo investigation. Fifteen healthy volunteers participated in a crossover, double-blind clinical study, using a 3-day partial-mouth plaque accumulation model. The participants abolished any method of mechanical oral hygiene and they were randomly assigned to initially use just the following mouthrinses: distilled water (DW solution), 0.12% chlorhexidine digluconate (CLX solution) or 10% Og (Og solution). The plaque index (PLI) was recorded in all mandibular teeth at the end of the trial and the Kruskal-Wallis (α=0...
October 2016: Brazilian Dental Journal
Wen J Liu, Li Fu, Mei Huang, Jing P Zhang, Yang Wu, Ying S Zhou, Jing Zeng, Guang X Wang
The aim of this study is to determine the frequency of quaternary ammonium compound-resistant genes, including qacA/B, qacC/D, qacE, qacΔE1, qacG, qacJ, and β-lactamase genes, including blaCTX-M, blaTEM, blaSHV, blaOXA-23, blaVIM, blaIMP, blaNDM and blaGIM in 51 isolates of carbapenem-resistant Acinetobacter baumannii collected over a period of 2 years and to determine the MIC of chlorhexidine and quaternary ammonium compound-based disinfectant benzalkonium chloride. The qac and bla genes were detected by the PCR method...
January 2017: Journal of Medical Microbiology
Maryam Sarbishegi, Ozra Khajavi, Mohammad Reza Arab
BACKGROUND: Phytotherapy is a popular treatment option in cases of benign prostatic hyperplasia (BPH), with many different herbal products being used for the treatment of this condition. Withania coagulans (WC) is an herbal medicine that has shown anti-tumoral, anti-inflammatory, and antioxidant effects. OBJECTIVES: This study examined the effect of Withania coagulans extract (WCE) on prostatic cell apoptosis and cyclooxygenase-2 (COX-2) expression in cases of benign prostatic hyperplasia (BPH) in rats...
September 2016: Nephro-urology Monthly
Carlos Eduardo Bezerra Gomes, Dhiogo Gonçalves Cavalcante, José Eduardo Girão Filho, Flávio Nogueira da Costa, Sérgio Luís da Silva Pereira
BACKGROUND: Plaque-associated gingivitis is a prevalent disease and research in its treatment using herbal agents must be encouraged to verify which would be a useful addition to the current range or chemotherapeutic treatment options. AIMS: The aim of this study was to evaluate the clinical effect of a mouth rinse containing 10% Anacardium occidentale (AO) Linn., a typical plant commonly found in the Northeast Region of Brazil, on the reduction of plaque and gingivitis in comparison to a gold-standard chemotherapeutic agent...
July 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
Mahesh Kandula, K B Sunil Kumar, Sivanesan Palanichamy, Ashok Rampal
Mesalamine (5-ASA) is one of the drugs indicated as first line therapy in ulcerative colitis for induction and maintenance of remission. Sulfasalazine and formulations of 5-ASA (pH-dependent and controlled release formulations) were developed to minimize the systemic absorption and maximize the delivery of the mesalamine to colon. Although, its efficacy and safety is well documented there are approximately 30% nonresponders to 5-ASA therapy. This necessitates the need for novel therapeutic options to improve the efficacy and safety of the currently available 5-ASA therapy...
November 2016: International Immunopharmacology
Mengzhen Li, Yue Li, Shin-Ichi Sasaki, Jiaxing Song, Chen Wang, Hitoshi Tamiaki, Wenjing Tian, Gang Chen, Tsutomu Miyasaka, Xiao-Feng Wang
Chlorophylls (Chls) are abundant, naturally occurring pigments that play key roles in light-harvesting and electron/energy transfer in natural photosynthetic apparatus. To demonstrate the idea that Chls are suitable hole transporters, we employed two Chl derivatives, Chl-1 and Chl-2, which self-assembled readily into π-stacking aggregates through a simple spincasting process, in perovskite solar cells (PSCs). The Chl aggregate films exhibit an ultra-smooth film surface, high hole mobility, appropriate energy levels, and efficient hole injection efficiencies that are all key characteristics for efficient hole transporters in PSCs...
October 6, 2016: ChemSusChem
Giovanni Ghibaudo, Davide Santospirito, Andrea Sala, Sara Flisi, Simone Taddei, Sandro Cavirani, Clotilde Silvia Cabassi
BACKGROUND: Pseudomonas aeruginosa (PA) may cause suppurative otitis externa with severe inflammation and ulceration in dogs. Multidrug resistance is commonly reported for this organism, creating a difficult therapeutic challenge. OBJECTIVE: The aim of this study was to evaluate the in vitro antimicrobial activity of a gel containing 0.5 μg/mL of antimicrobial peptide AMP2041, 0.07% chlorhexidine digluconate (CLX), 0.4% Tris and 0.1% EDTA on 30 clinical isolates of PA from canine otitis externa...
October 2016: Veterinary Dermatology
Delia Mandracchia, Giuseppe Tripodo, Adriana Trapani, Simona Ruggieri, Tiziana Annese, Theodora Chlapanidas, Giuseppe Trapani, Domenico Ribatti
Curcumin (CUR) and celecoxib (CLX) are two highly hydrophobic drugs which show bioavailability problems due to their poor aqueous solubility. The aim of this study was to encapsulate each of these drugs in micelles based on biodegradable and amphiphilic polymers to investigate their anti-angiogenesis activity. Here we use an amphiphilic polymer, based on two natural substances from renewable resources (Inulin and Vitamin E, INVITE), as a self-assembling system for the drug delivery of CUR and CLX. By the in vivo assay of chick embryo chorioallantoic membrane (CAM) it was assessed that both INVITE-CUR and INVITE-CLX micelles possess remarkable anti-angiogenic activity, while the INVITE micelles alone resulted intrinsically pro-angiogenic...
October 10, 2016: European Journal of Pharmaceutical Sciences
Haihua Zhang, Qing Liao, Xuedong Wang, Ke Hu, Jiannian Yao, Hongbing Fu
On page 3780, Q. Liao, H. Fu, and co-workers report a facile one-step solution self-assembly method for synthesizing single-crystalline nanofibers of MAPbI3-x Clx , in which substitution of Cl for I takes place at Iflank positions of the halide-octahedra in ab plane of perovskite tetragonal-lattice with Cl concentration from 0 to 25%. All single NF-based devices exhibit excellent photoresponse characteristics under the white-light illumination.
July 2016: Small
Ibon Alkorta, Jose Elguero, Janet E Del Bene
MP2/aug'-cc-pVTZ calculations have been carried out to investigate boron as an electron-pair donor in halogen-bonded complexes H(CO)2B:ClX and H(N2)2B:ClX, for X = F, Cl, OH, NC, CN, CCH, CH3, and H.Equilibrium halogen-bonded complexes with boron the electron-pair donor have been found on all of the potential surfaces except for H(CO)2B:ClCH3 and H(N2)2B:ClF.The majority of these complexes are stabilized by traditional halogen bonds, except for H(CO)2B:ClF, H(CO)2B:ClCl, H(N2)2B:ClCl, and H(N2)2B:ClOH which are stabilized by chlorine-shared halogen bonds...
July 14, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
İlker Doğan, Ryan Gresback, Tomohiro Nozaki, Mauritius C M van de Sanden
Temporal evolution of surface chemistry during oxidation of silicon quantum dot (Si-QD) surfaces were probed using surface-enhanced Raman scattering (SERS). A monolayer of hydrogen and chlorine terminated plasma-synthesized Si-QDs were spin-coated on silver oxide thin films. A clearly enhanced signal of surface modes, including Si-Clx and Si-Hx modes were observed from as-synthesized Si-QDs as a result of the plasmonic enhancement of the Raman signal at Si-QD/silver oxide interface. Upon oxidation, a gradual decrease of Si-Clx and Si-Hx modes, and an emergence of Si-Ox and Si-O-Hx modes have been observed...
2016: Scientific Reports
Carolina Carvalho, Fernando Pelegrim Fernandes, Valeria da Penha Freitas, Fabiana Mantovani Gomes França, Roberta Tarkany Basting, Cecilia Pedroso Turssi, Flávia Lucisano Botelho Amaral
OBJECTIVE: Green tea extract has been advocated as a matrix metalloproteinase (MMP) inhibitor; however, its effect on bond durability to caries-affected dentin has never been reported. Thus, the aim of this in vitro study was to evaluate the effect of two MMP inhibitors (2% chlorhexidine and 2% green tea extract), applied after acid etching, on bond durability of an etch-and-rinse adhesive system to caries-affected dentin. MATERIAL AND METHODS: Occlusal enamel was removed from third molars to expose the dentin surface, and the molars were submitted to a caries induction protocol for 15 days...
May 2016: Journal of Applied Oral Science: Revista FOB
Renée Onnainty, Barbara Onida, Paulina Páez, Marcela Longhi, Antonello Barresi, Gladys Granero
The purpose of this study was to develop sustained release systems based on chitosan (CS) and montmorillonite (MMT) for chlorhexidine (CLX). Nanocomposites were prepared by ion-exchange. CLX systems were characterized by X-ray powder diffraction (XRD), thermal analysis (TGA), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray fluorescence analysis (XRF). The mucoadhesion properties of CLX nanocomposites were evaluated by SEM. The release behavior of these systems was also studied by the dialysis technique...
July 25, 2016: International Journal of Pharmaceutics
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