María Ángeles García-López, Alfonso Mora, Patricia Corrales, Tirso Pons, Ainhoa Sánchez de Diego, Amaia Talavera Gutiérrez, Karel H M van Wely, Gema Medina-Gómez, Guadalupe Sabio, Carlos Martínez-A, Thierry Fischer
The prevalence of overweight and obesity continues to rise in the population worldwide. Because it is an important predisposing factor for cancer, cardiovascular diseases, diabetes mellitus, and COVID-19, obesity reduces life expectancy. Adipose tissue (AT), the main fat storage organ with endocrine capacity, plays fundamental roles in systemic metabolism and obesity-related diseases. Dysfunctional AT can induce excess or reduced body fat (lipodystrophy). Dido1 is a marker gene for stemness; gene-targeting experiments compromised several functions ranging from cell division to embryonic stem cell differentiation, both in vivo and in vitro...
January 16, 2024: Proceedings of the National Academy of Sciences of the United States of America