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https://www.readbyqxmd.com/read/29779405/how-many-patients-in-a-prolonged-disorder-of-consciousness-might-need-a-best-interests-meeting-about-starting-or-continuing-gastrostomy-feeding
#1
Derick T Wade
OBJECTIVE: To estimate the number of people in a prolonged disorder of consciousness (PDOC) who may need a formal best interests decision-making process to consider starting and/or continuing life-sustaining treatment each year in the population of a developed country. METHOD: Identification of studies on people with a PDOC giving information about incidence, and/or prevalence, and/or cause, and/or location of long-term care. Sources included systematic reviews, a new search of MEDLINE (April 2018), and a personal collection of papers...
May 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29779138/cognitive-syndromes-after-the-first-stroke
#2
Denisa Salihović, Dževdet Smajlović, Milija Mijajlović, Emina Zoletić, Omer Ć Ibrahimagić
AIM: The aim of this study is to determine impairments of certain cognitive functions in certain vascular cognitive syndromes and to identify predictors of dementia. PATIENTS AND METHODS: One-year prospective study included 275 patients, who were hospitalized at the Department of Neurology Tuzla and therefore fulfilled certain criteria. Patients were divided into following subgroups of vascular cognitive impairment (VCI): dementia of strategic infarct (DSI), cortical dementia (CD), sub cortical dementia (SCD), hemorrhagic dementia (HD), and patients without dementia...
May 19, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29778641/subregional-volumes-of-the-hippocampus-in-relation-to-cognitive-function-and-risk-of-dementia
#3
Tavia E Evans, Hieab H H Adams, Silvan Licher, Frank J Wolters, Aad van der Lugt, M Kamran Ikram, Michael J O'Sullivan, Meike W Vernooij, M Arfan Ikram
BACKGROUND: Total hippocampal volume has been consistently linked to cognitive function and dementia. Yet, given its complex and parcellated internal structure, the role of subregions of the hippocampus in cognition and risk of dementia remains relatively underexplored. We studied subregions of the hippocampus in a large population-based cohort to further understand their role in cognitive impairment and dementia risk. METHODS: We studied 5035 dementia- and stroke-free persons from the Rotterdam Study, aged over 45 years...
May 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29769252/frequency-of-non-motor-symptoms-in-parkinson-s-disease-presenting-to-tertiary-care-centre-in-pakistan-an-observational-cross-sectional-study
#4
Shahid Mukhtar, Rashid Imran, Mohsin Zaheer, Huma Tariq
OBJECTIVE: To determine the frequency of non-motor symptoms (NMS) in patients of Parkinson's disease (PD) presenting to a movement disorder clinic at a tertiary care centre in Pakistan, and how frequency of NMS is different in male and female patients. STUDY DESIGN: Observational, cross-sectional study. SETTING: Tertiary care centre. PARTICIPANTS: Out of 102 patients, 85 were included. Inclusion criteria were patients with PD diagnosed according to the UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria, age ≥18 years, able to give consent and have no difficulty in answering questions...
May 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29768942/updated-meta-review-of-evidence-on-support-for-carers
#5
Jane Dalton, Sian Thomas, Melissa Harden, Alison Eastwood, Gillian Parker
Objective To update a 2010 meta-review of systematic reviews of effective interventions to support carers of ill, disabled, or older adults. In this article, we report the most promising interventions based on the best available evidence. Methods Rapid meta-review of systematic reviews published from January 2009 to 2016. Results Sixty-one systematic reviews were included (27 high quality, 25 medium quality, and nine low quality). The quality of reviews has improved since the original review, but primary studies remain limited in quality and quantity...
January 1, 2018: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29768278/lower-plasma-klotho-concentrations-are-associated-with-vascular-dementia-but-not-late-onset-alzheimer-s-disease
#6
Gloria Brombo, Francesco Bonetti, Beatrice Ortolani, Mario Luca Morieri, Cristina Bosi, Angelina Passaro, Giovanni B Vigna, Caterina Borgna, Maria Vittoria Arcidicono, Veronica Tisato, Giovanni Zuliani
BACKGROUND: The protein Klotho is involved in biological processes related to longevity, cardiovascular health, and cognition. Serum Klotho levels have been associated with better cognition in animal models; moreover, lower Klotho concentrations in cerebrospinal fluid from subjects with late-onset Alzheimer's disease (LOAD) have been reported. OBJECTIVE: Our study aimed to examine the possible relationship between Klotho plasma concentrations and cognitive status in the elderly...
May 16, 2018: Gerontology
https://www.readbyqxmd.com/read/29764435/use-of-hospital-palliative-care-according-to-the-place-of-death-and-disease-one-year-before-death-in-2013-a-french-national-observational-study
#7
Claire Poulalhon, Laureen Rotelli-Bihet, Sébastien Moine, Anne Fagot-Campagna, Régis Aubry, Philippe Tuppin
BACKGROUND: Only limited data are available concerning the diseases managed before death and hospital palliative care (HPC) use according to place of death in France. We therefore conducted an observational study based on administrative health data in a large population to identify the diseases treated one year before death in 2013, the place of stay with or without hospital palliative care, and the place of death. METHODS: French health insurance general scheme beneficiaries were identified in the National Health data Information System (Snds) with a selection of information...
May 16, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29763917/relevance-of-dementia-in-atrial-fibrillation-patients-within-a-specific-european-health-care-area
#8
Moisés Rodríguez-Mañero, Estrella López-Pardo, Alberto Cordero, Omar Kreidieh, José Novo Platas, Luis Valdés, Adrian Cid-Menendez, Javier García-Seara, María Pereira-Vázquez, Jose-Luis Martínez-Sande, Alberto Ruano, Carlos Peña-Gil, Pilar Mazón, Jose María García-Acuña, José Ramón González-Juanatey
INTRODUCTION: Atrial fibrillation might increase the risk of dementia. We aim to test the hypothesis that dementia could reclassify the actual risk of stroke and death predicted by the CHA2DS2-VASc in patients with atrial fibrillation (AF). METHODS: A prospective study performed in a specific health care area. RESULTS: From our health care area (n = 348,985), throughout 2013, AF was codified in 7,990 (2.08%). Mean age was 76.83 ± 10.5, mean CHA2DS2-VASc = 3...
May 15, 2018: Neuroepidemiology
https://www.readbyqxmd.com/read/29755351/gastrodin-attenuates-bilateral-common-carotid-artery-occlusion-induced-cognitive-deficits-via-regulating-a%C3%AE-related-proteins-and-reducing-autophagy-and-apoptosis-in-rats
#9
Bo Liu, Jian-Mei Gao, Fei Li, Qi-Hai Gong, Jing-Shan Shi
Gastrodin (GAS), an active constituent extracted from Gastrodia elata Blume, is used to treat ischemic stroke, epilepsy, dizziness, and dementia for centuries in China. This study examined its effects on vascular dementia (VD) and the underlying molecular mechanisms. VD was established by ligation of bilateral common carotid artery occlusion (BCCAO). A total of 7 days after BCCAO surgery, GAS (15, 30, and 60 mg/kg) was orally administered for 28 consecutive days to evaluate therapeutic effects. Cognitive function was tested by the Morris water maze...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29752348/genetic-study-of-white-matter-integrity-in-uk-biobank-n-8448-and-the-overlap-with-stroke-depression-and-dementia
#10
Loes C A Rutten-Jacobs, Daniel J Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S Markus, Matthew Traylor
BACKGROUND AND PURPOSE: Structural integrity of the white matter is a marker of cerebral small vessel disease, which is the major cause of vascular dementia and a quarter of all strokes. Genetic studies provide a way to obtain novel insights in the disease mechanism underlying cerebral small vessel disease. The aim was to identify common variants associated with microstructural integrity of the white matter and to elucidate the relationships of white matter structural integrity with stroke, major depressive disorder, and Alzheimer disease...
May 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29748641/xiaoshuan-enteric-coated-capsule-alleviates-cognitive-impairment-by-enhancing-hippocampal-glucose-metabolism-hemodynamics-and-neuroplasticity-of-rat-with-chronic-cerebral-hypoperfusion
#11
Man-Zhong Li, Yi Zhang, Hai-Yan Zou, Ya-Li Wang, Brian-Chi Yan Cheng, Lei Wang, Qiu-Xia Zhang, Jian-Feng Lei, Hui Zhao
Chronic cerebral hypoperfusion (CCH) is identified as a critical risk factor of dementia in patients with cerebrovascular disease. Xiaoshuan enteric-coated capsule (XSECC) is a compound Chinese medicine approved by Chinese State Food and Drug Administration for promoting brain remodeling and plasticity after stroke. The present study aimed to explore the potential of XSECC to improve cognitive function after CCH and further investigate the underlying mechanisms. CCH was induced by bilateral common carotid artery occlusion (BCCAO) in rats...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740562/effects-of-exercise-training-on-stroke-risk-factors-homocysteine-concentration-and-cognitive-function-according-the-apoe-genotype-in-stroke-patients
#12
Jun-Hee Lee, Sang-Min Hong, Yun-A Shin
The apolipoprotein E ( APOE ) gene has been suggested to be associated with stroke and dementia. However, the effects of exercise training on dementia according to the APOE genotype are not consistent to those reported by previous studies. Therefore, we examined the effects of exercise training on stroke risk factors including blood pressure, lipid profiles, homocysteine (Hcy) concentrations, and cognitive function according to the APOE genotype in stroke patients. We examined the stroke risk factors, Hcy, and cognitive function in 28 ischemic stroke patients before and after 6 months of exercise training...
April 2018: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29727395/the-effect-of-an-educational-pamphlet-on-patient-knowledge-of-and-intention-to-discuss-screening-for-obstructive-sleep-apnea-in-the-acute-ischemic-stroke-population
#13
Ryan A Donald, Ruta Arays, John O Elliott, Kim Jordan
BACKGROUND: The relationship between obstructive sleep apnea (OSA) and stroke is well established, thus supporting the importance of secondary prevention via screening and treatment for acute ischemic stroke survivors. Educational pamphlets are commonly used for patient education; however, none currently available on OSA have evaluated. The aim of this study was to evaluate the effect of a brief educational intervention on patient knowledge and interest in OSA screening. METHODS: Adult acute ischemic stroke patients were enrolled into a nonrandomized, single-group, pretest and posttest study...
June 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29726891/understanding-the-role-of-the-perivascular-space-in-cerebral-small-vessel-disease
#14
Rosalind Brown, Helene Benveniste, Sandra E Black, Serge Charpak, Martin Dichgans, Anne Joutel, Maiken Nedergaard, Kenneth J Smith, Berislav V Zlokovic, Joanna M Wardlaw
Small vessel diseases are a group of disorders that result from pathological alteration of the small blood vessels in the brain, including the small arteries, capillaries and veins. Of the 35-36 million people that are estimated to suffer from dementia worldwide, up to 65% have an SVD component. Furthermore, SVD causes 20-25% of strokes, worsens outcome after stroke and is a leading cause of disability, cognitive impairment and poor mobility. Yet the underlying cause(s) of SVD are not fully understood.Magnetic resonance imaging (MRI) has confirmed enlarged perivascular spaces (PVS) as a hallmark feature of SVD...
May 2, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29723680/selective-impairments-in-components-of-affective-prosody-in-neurologically-impaired-individuals
#15
Amy Wright, Sadhvi Saxena, Shannon M Sheppard, Argye E Hillis
The intent and feelings of the speaker are often conveyed less by what they say than by how they say it, in terms of the affective prosody - modulations in pitch, loudness, rate, and rhythm of the speech to convey emotion. Here we propose a cognitive architecture of the perceptual, cognitive, and motor processes underlying recognition and generation of affective prosody. We developed the architecture on the basis of the computational demands of the task, and obtained evidence for various components by identifying neurologically impaired patients with relatively specific deficits in one component...
April 30, 2018: Brain and Cognition
https://www.readbyqxmd.com/read/29716786/systemic-and-ocular-determinants-of-peripapillary-retinal-nerve-fiber-layer-thickness-measurements-in-the-european-eye-epidemiology-e3-population
#16
Matthias M Mauschitz, Pieter W M Bonnemaijer, Kersten Diers, Franziska G Rauscher, Tobias Elze, Christoph Engel, Markus Loeffler, Johanna Maria Colijn, M Arfan Ikram, Johannes R Vingerling, Katie M Williams, Christopher J Hammond, Catherine Creuzot-Garcher, Alain M Bron, Rufino Silva, Sandrina Nunes, Cécile Delcourt, Audrey Cougnard-Grégoire, Frank G Holz, Caroline C W Klaver, Monique M B Breteler, Robert P Finger
PURPOSE: To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. DESIGN: Cross-sectional meta-analysis. PARTICIPANTS: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3-82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. METHODS: We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis...
April 28, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29712883/small-vessels-dementia-and-chronic-diseases-molecular-mechanisms-and-pathophysiology
#17
REVIEW
Karen Horsburgh, Joanna M Wardlaw, Tom van Agtmael, Stuart M Allan, Mike L J Ashford, Philip M Bath, Rosalind Brown, Jason Berwick, M Zameel Cader, Roxana O Carare, John B Davis, Jessica Duncombe, Tracy D Farr, Jill H Fowler, Jozien Goense, Alessandra Granata, Catherine N Hall, Atticus H Hainsworth, Adam Harvey, Cheryl A Hawkes, Anne Joutel, Rajesh N Kalaria, Patrick G Kehoe, Catherine B Lawrence, Andy Lockhart, Seth Love, Malcolm R Macleod, I Mhairi Macrae, Hugh S Markus, Chris McCabe, Barry W McColl, Paul J Meakin, Alyson Miller, Maiken Nedergaard, Michael O'Sullivan, Terry J Quinn, Rikesh Rajani, Lisa M Saksida, Colin Smith, Kenneth J Smith, Rhian M Touyz, Rebecca C Trueman, Tao Wang, Anna Williams, Steven C R Williams, Lorraine M Work
Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation...
April 30, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29706487/acetylcholinesterase-inhibitors-and-risk-of-stroke-and-death-in-people-with-dementia
#18
Edwin C K Tan, Kristina Johnell, Sara Garcia-Ptacek, Miriam L Haaksma, Johan Fastbom, J Simon Bell, Maria Eriksdotter
INTRODUCTION: The aim of this study was to investigate the association between acetylcholinesterase inhibitor (AChEI) use and risk of ischemic stroke and death in people with dementia. METHODS: A cohort study of 44,288 people with dementia registered in the Swedish Dementia Registry from 2007 to 2014. Propensity score-matched competing risk regression models were used to compute hazard ratios and 95% confidence intervals for the association between time-dependent AChEI use and risk of stroke and death...
April 5, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29704209/neurologic-manifestations-of-elderly-patients-with-cancer
#19
Bernardo Cacho-Díaz, Nydia A Lorenzana-Mendoza, Gervith Reyes-Soto, José A Ávila-Funes, Ana P Navarrete-Reyes
BACKGROUND: The incidence of cancer is an age-related phenomenon; therefore, the interest on clinical manifestations, diagnostic approach and treatment strategies for older patients diagnosed with cancer has increased lately. Neurologic symptoms are one of the main reasons for consultation and a common cause of decreased quality of life among cancer patients. AIMS: To identify the neurologic manifestations of patients ≥ 65 years of age diagnosed with cancer and compare them to those presented by a younger population...
April 27, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29703211/factors-influencing-quality-of-life-in-patients-followed-in-the-neurosonology-laboratory-for-carotid-stenosis
#20
Táňa Fadrná, Zdeňka Mikšová, Roman Herzig, Kateřina Langová, Libor Ličman, David Školoudík
BACKGROUND: Quality of life (QoL) is one of the main endpoints in stroke prevention or acute stroke treatment studies. The aim of the current study was to identify risk factors affecting the QoL of patients with carotid stenosis in stroke prevention. METHODS: Self-sufficient patients (50-80 years of age) with ≥20% carotid artery stenosis followed in the neurosonology laboratory, and without any severe illnesses within the last 12 months, dementia, or psychiatric disorders were selected for the study after signing informed consent...
April 27, 2018: Health and Quality of Life Outcomes
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