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exertional compartment syndrome

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https://www.readbyqxmd.com/read/28428247/induction-of-cell-death-and-gain-of-function-properties-of-connexin26-mutants-predict-severity-of-skin-disorders-and-hearing-loss
#1
Eric R Press, Qing Shao, John J Kelly, Katrina Chin, Anton Alaga, Dale W Laird
Connexin26 (Cx26) is a gap junction protein that oligomerizes in the cell to form hexameric transmembrane channels called connexons. Cell surface connexons dock between adjacent cells to allow for gap junctional intercellular communication. Numerous autosomal dominant mutations in the Cx26 encoding GJB2 gene lead to many skin disorders and sensorineural hearing loss. Although some insights have been gained into the pathogenesis of these diseases, it is not fully understood how distinct GJB2 mutations result in hearing loss alone or in skin pathologies with comorbid hearing loss...
April 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28303472/chronic-exertional-compartment-syndrome-in-the-forearm-of-a-collegiate-softball-pitcher
#2
REVIEW
Austin Cole, John L Hiatt, Christopher Arnold, Terry Sites, Ramon Ylanon
BACKGROUND: Chronic exertional compartment syndrome (CECS) is a recognized condition in the lower limb, with many reports in the literature. However, very few instances include CECS of the upper limb. This article presents the case of a collegiate softball pitcher presenting with CECS in her right forearm. To our knowledge, this is the first case report of a softball player with CECS, with only one similar incident in a major league baseball player. PURPOSE: The rarity of this condition normally places it low on the differential diagnosis...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28236094/-diseases-and-overuse-injuries-of-the-lower-extremities-in-long-distance-runners
#3
REVIEW
M Tschopp, F Brunner
Running is one of the most popular sports worldwide, with running events attracting hundreds of thousands of runners of all age groups. Running is an effective way to improve health but is also associated with a high risk of injuries. Up to 50% of regular runners report having more than one injury each year. Some injuries are caused by an accident but most are caused by overuse. The most frequent diagnoses are patellofemoral pain syndrome, tibial stress syndrome (shin splint), Achilles tendinopathy, iliotibial band friction syndrome (runner's knee), plantar fasciitis and stress fractures of the metatarsals and tibia...
February 24, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28136130/integrin-%C3%AE-8-is-abundant-in-human-rat-and-mouse-trophoblasts
#4
Sebastian Herdl, Hanna Huebner, Gudrun Volkert, Ines Marek, Carlos Menendez-Castro, Stephanie C Noegel, Matthias Ruebner, Wolfgang Rascher, Andrea Hartner, Fabian B Fahlbusch
OBJECTIVE: Integrins exert regulatory functions in placentogenesis. Null mutation of certain integrin α subunits leads to placental defects with subsequent fetal growth restriction or embryonic lethality in mice. So far, the placental role of α8 integrin remains to be determined. METHODS: Localization of α8 integrin and its ligands, fibronectin (FN) and osteopontin (OPN), was studied by immunohistochemistry in human, rat, and mouse placenta. The vascularization of the placental labyrinth layer of α8 integrin-deficient mice was determined by CD31 staining...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28123920/spinning-out-of-control-a-19-year-old-female-with-spinning-related-exertional-thigh-compartment-syndrome
#5
Daniel J Gould, Ido Badash, Sukgu Han, Alex K Wong
Thigh compartment syndrome (TCS) is a rare condition caused by high pressures within the fascial compartments of the thigh, impeding capillary flow and leading to decreased perfusion, tissue hypoxia, and necrosis. TCS is most frequently associated with trauma and anticoagulation but has also rarely been associated with exercise-related injury. We present the case of a 19-year-old female who reported painful swelling in her thighs and darkening of her urine after participating in a spinning class. On physical examination, the patient was found to have tight, painful thigh compartments with extreme tenderness on passive motion...
December 24, 2016: Curēus
https://www.readbyqxmd.com/read/28027611/ultrasound-guided-fasciotomy-for-anterior-chronic-exertional-compartment-syndrome-of-the-leg
#6
Ramon Balius, David A Bong, Jordi Ardèvol, Carles Pedret, David Codina, Antonio Dalmau
Chronic exertional compartment syndrome is characterized by exertional pain and elevated intracompartmental pressures affecting the leg in physically active young people. In patients who have failed conservative measures, fasciotomy is the treatment of choice. This study presents a new method for performing fasciotomy using high-resolution ultrasound (US) guidance and reports on the clinical outcomes in a group of these patients. Over a 3-year period, 7 consecutive patients with a total of 9 involved legs presented clinically with anterior compartment chronic exertional compartment syndrome, which was confirmed by intracompartmental pressure measurements before and after exercise...
April 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27999729/a-non-operative-approach-to-the-management-of-chronic-exertional-compartment-syndrome-in-a-triathlete-a-case-report
#7
Cristiana Kahl Collins, Brad Gilden
BACKGROUND & PURPOSE: Chronic Exertional Compartment Syndrome (CECS) causes significant exercise related pain secondary to increased intra-compartmental pressure (ICP) in the lower extremities. CECS is most often treated with surgery with minimal information available on non-operative approaches to care. This case report presents a case of CECS successfully managed with physical therapy. STUDY DESIGN: Case report. CASE DESCRIPTION: A 34-year-old competitive triathlete experienced bilateral anterior and posterior lower leg pain measured with a numerical pain rating scale of 7/10 at two miles of running...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27999725/modifying-marching-technique-in-military-service-members-with-chronic-exertional-compartment-syndrome-a-case-series
#8
Pieter H Helmhout, Maj Angela Diebal-Lee, Laurens R Poelsma, Chris C Harts, Ltc Wes O Zimmermann
BACKGROUND AND PURPOSE: The long-term effectiveness of both operative and non-operative management approaches for Chronic Exertional Compartment Syndrome of the lower legs (CECS) is moderate at best. Positive outcomes have recently been reported on modifying running technique in individuals with CECS. The purpose of this case series was to evaluate a training program aimed at changing marching technique in individuals with CECS, based on principles that aim to eliminate heel strike and decrease impact during foot strike...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27915161/intestinal-multidrug-resistance-associated-protein-2-is-down-regulated-in-fructose-fed-rats
#9
Ana Sofía Londero, Maite Rocío Arana, Virginia Gabriela Perdomo, Guillermo Nicolás Tocchetti, Felipe Zecchinati, Carolina Inés Ghanem, María Laura Ruiz, Juan Pablo Rigalli, Aldo Domingo Mottino, Fabiana García, Silvina Stella Maris Villanueva
Expression and activity of jejunal multidrug resistance-associated protein 2 (Mrp2) and glutathione-S-transferase (GST) were examined in fructose fed Wistar rats, an experimental model of metabolic syndrome. Animals were fed on (a) control diet or (b) control diet plus 10% w/vol fructose in the drinking water. Mrp2 and the α class of GST proteins as well as their corresponding mRNAs were decreased, suggesting a transcriptional regulation by fructose. Confocal microscopy studies reaffirmed down-regulation of Mrp2...
November 9, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27875493/acute-lumbar-paraspinal-myonecrosis-in-football-players-with-sickle-cell-trait-a-case-series
#10
E Randy Eichner, Brock Schnebel, Scott Anderson, James R Clugston, Matthew Heath Hale, Charlie Michaudet, John M Small
We report six cases of a novel syndrome of acute, exertional low back pain in football players, five in college and one in the National Football League. All six are African Americans with sickle cell trait (SCT). The acute low back pain is severe and can be disabling, and the condition can be confused with muscle strain, discogenic pain, stress fracture, or other problems in athletes. Our evidence shows that this syndrome is caused by lumbar paraspinal myonecrosis (LPSMN), which likely often contributes to the lumbar paraspinal compartment syndrome...
April 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27760845/external-iliac-artery-vasospasm-in-an-elite-female-runner
#11
Kristin L Garlanger, Elena J Jelsing, Jonathan T Finnoff
A 33-year-old elite female runner presented to a tertiary care sports medicine clinic with a 2-year history of progressive anterior thigh and circumferential leg pain with associated foot paresthesias brought on by high-intensity running. She had both external iliac artery vasospasm and chronic exertional compartment syndrome. External iliac artery vasospasm is a rare cause of exertional leg pain, particularly in the running population. This case highlights the unique features of this condition, addresses the multidisciplinary approach that led to the accurate diagnoses, and demonstrates that more than 1 etiology for exertional leg pain can coexist in an athlete...
October 19, 2016: Sports Health
https://www.readbyqxmd.com/read/27672904/poster-137-delayed-diagnosis-of-popliteal-artery-entrapment-mistaken-for-exertional-compartment-syndrome-novel-use-of-msk-us-to-improve-diagnostic-sensitivity-a-case-report
#12
Ilya Igolnikov, Matthew J Santiago, Kathryn T Gollotto
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27670876/single-minimal-incision-fasciotomy-for-the-treatment-of-chronic-exertional-compartment-syndrome-outcomes-and-complications
#13
Michael Drexler, T Frenkel Rutenberg, N Rozen, Y Warschawski, E Rath, O Chechik, G Rachevsky, G Morag
INTRODUCTION: Chronic exertional compartment syndrome (CECS) is a common injury in young athletes, causing pain in the involved leg compartment during strenuous exercise. The gold standard treatment is fasciotomy, but most of the reports on its effectiveness include relatively small cohorts and relatively short follow-up periods. This study reports the long-term results of a large cohort of young athletes who underwent single-incision fasciotomy for CECS. MATERIALS AND METHODS: This a retrospective case-series study...
January 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27639651/ultrasound-guided-fasciotomy-for-chronic-exertional-compartment-syndrome-a-cadaveric-investigation
#14
Daniel R Lueders, Jacob L Sellon, Jay Smith, Jonathan T Finnoff
BACKGROUND: Chronic exertional compartment syndrome (CECS) is a common cause of exertional leg pain. It is commonly treated with a surgical fasciotomy, which has a surgical complication rate of up to 16% and takes approximately 6-12 weeks to return to preprocedure activity levels. Therefore, the development of a less invasive, effective outpatient intervention to treat CECS is desirable. OBJECTIVE: To describe and validate an ultrasound-guided (USG) fasciotomy technique for the anterior and lateral compartments of the lower limb in an unembalmed cadaveric model...
September 14, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27612357/short-term-results-of-a-rehabilitation-program-for-service-members-with-lower-leg-pain-and-the-evaluation-of-patient-characteristics
#15
Mariëtte Z Meulekamp, Wieteke Sauter, Marieke Buitenhuis, Agali Mert, Peter van der Wurff
INTRODUCTION: Lower leg pain (LLP), including medial tibial stress syndrome (MTSS) and chronic exertional compartment syndrome (CECS), remains a major problem for the military. OBJECTIVE: Evaluation of patient characteristics and short-term results of the rehabilitation program for service members used in the Military Rehabilitation Centre Aardenburg. METHODS: This retrospective study includes 161 service members of the Netherlands Armed Forces...
September 2016: Military Medicine
https://www.readbyqxmd.com/read/27510179/selective-expansion-of-regulatory-t-cells-during-lenalidomide-treatment-of-myelodysplastic-syndrome-with-isolated-deletion-5q
#16
MULTICENTER STUDY
Ekaterina Balaian, Claudia Schuster, Claudia Schönefeldt, Ulrich Germing, Detlef Haase, Sebastian Tuve, Rainer Ordemann, Gerhard Ehninger, Martin Bornhäuser, Uta Oelschlaegel, Brigitte Mohr, Malte von Bonin, Uwe Platzbecker, Martin Wermke
Lenalidomide (LEN) leads to erythroid improvement in the majority of patients with myelodysplastic syndrome and isolated deletion of the long arm of chromosome 5 (MDS-del(5q)). This effect is believed to be exerted via its immunomodulatory properties, although the precise nature is still incompletely understood. We prospectively performed immune profiling in the bone marrow and blood of MDS-del(5q) patients undergoing LEN therapy for a median of 6 cycles. Therapy with LEN led to a significant increase in the median absolute lymphocyte count (1...
October 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27466182/shoc2-subcellular-shuttling-requires-the-keke-motif-rich-region-and-n-terminal-leucine-rich-repeat-domain-and-impacts-on-erk-signaling
#17
Marialetizia Motta, Giovanni Chillemi, Valentina Fodale, Serena Cecchetti, Simona Coppola, Silvia Stipo, Viviana Cordeddu, Pompeo Macioce, Bruce D Gelb, Marco Tartaglia
SHOC2 is a scaffold protein composed almost entirely by leucine-rich repeats (LRRs) and having an N-terminal region enriched in alternating lysine and glutamate/aspartate residues (KEKE motifs). SHOC2 acts as positive modulator of the RAS-RAF-MEK-ERK signaling cascade by favoring stable RAF1 interaction with RAS. We previously reported that the p.Ser2Gly substitution in SHOC2 underlies Mazzanti syndrome, a RASopathy clinically overlapping Noonan syndrome, promoting N-myristoylation and constitutive targeting of the mutant to the plasma membrane...
July 27, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27454495/endoscopic-single-approach-forearm-fasciotomy-for-chronic-exertional-compartment-syndrome-long-term-follow-up
#18
L Pegoli, A Pozzi, G Pivato
BACKGROUND: Chronic exertional compartment syndrome of the forearm is an uncommon condition, occurring in some populations such as athletes. The standard surgical treatment for professional athletes who cannot avoid trigger activity is an open forearm fasciotomy, which may require a long recovery time. The aim of this study is to present a new endoscopic single approach forearm fasciotomy technique and outcomes of at least 3 years follow up. METHODS: We performed the endoscopic single approach forearm fasciotomy in 4 forearms in 3 men with the mean age of 25 years...
February 2016: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/27451420/prevention-and-treatment-of-exercise-related-leg-pain-in-young-soldiers-a-review-of-the-literature-and-current-practice-in-the-dutch-armed-forces
#19
REVIEW
Wes O Zimmermann, P H Helmhout, A Beutler
Overuse injuries of the leg are a common problem for young soldiers. This article reviews the literature concerning the prevention and treatment of exercise related leg pain in military settings and presents the latest developments in proposed mechanisms and treatments. Current practice and treatment protocols from the Dutch Armed Forces are reviewed, with an emphasis on the most prevalent conditions of medial tibial stress syndrome and chronic exertional compartment syndrome. The conclusion is that exercise related leg pain in the military is an occupational problem that deserves further study...
July 22, 2016: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/27411805/considerations-for-systemic-treatment-of-psoriasis-in-obese-patients
#20
REVIEW
Paolo Gisondi, Micol Del Giglio, Giampiero Girolomoni
Psoriasis is an immune-mediated inflammatory skin disease frequently associated with metabolic disorders, including diabetes, dyslipidaemia and metabolic syndrome. Moreover, a growing number of studies confirm the association between psoriasis and obesity. It has been found that obesity, as measured by body mass index >30 kg/m(2), can double the risk of incident psoriasis. A positive correlation between different measures of adiposity and the severity of psoriasis has also been reported. Epidemiologic studies have also provided robust evidence confirming the association between obesity and psoriatic arthritis...
December 2016: American Journal of Clinical Dermatology
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