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exertional compartment syndrome

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https://www.readbyqxmd.com/read/29712732/sirtuins-in-renal-health-and-disease
#1
REVIEW
Marina Morigi, Luca Perico, Ariela Benigni
Sirtuins belong to an evolutionarily conserved family of NAD+ -dependent deacetylases that share multiple cellular functions related to proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammalians express seven sirtuins (SIRT1-7) that are localized in different subcellular compartments. Changes in sirtuin expression are critical in several diseases, including metabolic syndrome, diabetes, cancer, and aging. In the kidney, the most widely studied sirtuin is SIRT1, which exerts cytoprotective effects by inhibiting cell apoptosis, inflammation, and fibrosis together with SIRT3, a crucial metabolic sensor that regulates ATP generation and mitochondrial adaptive response to stress...
April 30, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29702369/barefoot-plantar-pressure-measurement-in-chronic-exertional-compartment-syndrome
#2
D Roscoe, A J Roberts, D Hulse, A Shaheen, M P Hughes, A Bennett
BACKGROUND: Patients with Chronic Exertional Compartment Syndrome (CECS) have exercise-limiting pain that subsides at rest. Diagnosis is confirmed by intramuscular compartment pressure (IMCP) measurement. Accompanying CECS, subjective changes to gait (foot slap) are frequently reported by patients. This has not previously been investigated. The aim of this study was to investigate differences in barefoot plantar pressure (BFPP) between CECS cases and asymptomatic controls prior to the onset of painful symptoms...
April 9, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29691307/effects-of-anterior-compartment-fasciotomy-on-intramuscular-compartment-pressure-in-patients-with-chronic-exertional-compartment-syndrome
#3
David Roscoe, A J Roberts, D Hulse, A F Shaheen, M P Hughes, A N Bennet
BACKGROUND: Patients with chronic exertional compartment syndrome (CECS) have pain during exercise that usually subsides at rest. Diagnosis is usually confirmed by measurement of intramuscular compartment pressure (IMCP) following exclusion of other possible causes. Management usually requires fasciotomy but reported outcomes vary widely. There is little evidence of the effectiveness of fasciotomy on IMCP. Testing is rarely repeated postoperatively and reported follow-up is poor. Improved diagnostic criteria based on preselection and IMCP levels during dynamic exercise testing have recently been reported...
April 24, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29621017/exertional-medial-compartment-syndrome-of-the-foot-referred-pain-and-sequelae-of-delayed-diagnosis-a-case-report
#4
Young Hwan Park, Jeong Hwan Ahn, Gi Won Choi, Hak Jun Kim
In a 31-year-old man, the diagnosis of medial compartment syndrome of foot was delayed for 8 days. In contrast to previously reported cases, the patient presented with mainly bilateral lateral thigh-referred pain rather than foot pain. Although delayed decompression of the medial compartment provided dramatic relief of the referred pain, the patient complained of sensory deficit at the medial side of the foot and flexion deformity of the great toe at the final follow-up visit. Medial compartment syndrome of the foot can cause referred pain, and delayed or missed diagnosis can cause irreversible damage...
April 4, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29581144/chronic-exertional-compartment-syndrome-of-the-deep-posterior-lower-leg
#5
Michiel B Winkes, Marc R Scheltinga
No abstract text is available yet for this article.
March 26, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29560004/avoiding-the-trap-of-misdiagnosis-valuable-teaching-points-derived-from-a-case-of-longstanding-popliteal-artery-entrapment-syndrome
#6
Heitham Wady, Zain Badar, Zerwa Farooq, Palma Shaw, Katsuhiro Kobayashi
Popliteal artery entrapment syndrome (PAES), a condition predominantly affecting young individuals, is a rare clinical entity that can result in significant morbidity. The presence of lower limb pain and claudication in young, physically active individuals should prompt consideration for PAES. Early diagnosis and management is crucial to prevent long-term complications; however, diagnosis is fraught with challenges due to the rarity of the disease and its similar clinical presentation with more common conditions...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29531960/lower-leg-chronic-exertional-compartment-syndrome-in-patients-50-years-of-age-and-older
#7
Johan A de Bruijn, Aniek P M van Zantvoort, Michiel B Winkes, Marike van der Cruijsen-Raaijmakers, Adwin R Hoogeveen, Joep A W Teijink, Marc R M Scheltinga
Background: Lower leg chronic exertional compartment syndrome (CECS) is usually diagnosed in young and athletic individuals. The presence of CECS in older patients has received little attention in the literature, and patient characteristics are unknown. Purpose: To determine the prevalence of CECS in older patients (≥50 years) and to assess whether older patients with CECS differ clinically from younger patients with CECS. Study Design: Cohort study; Level of evidence, 3...
March 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29502519/identifying-prognostic-factors-for-conservative-treatment-outcomes-in-servicemen-with-chronic-exertional-compartment-syndrome-treated-at-a-rehabilitation-center
#8
Mariëtte Z Meulekamp, Peter van der Wurff, Alfred van der Meer, Cees Lucas
BACKGROUND: Chronic exertional compartment syndrome (CECS) is a condition of pain induced by exercise, and it is characterized by muscle swelling and impaired muscle function in the lower leg. Given the diversity in the diagnosis and treatment of CECS, it is desirable to determine variables pertaining to prognosis and recovery. The purpose of this study is to identify prognostic factors for conservative treatment outcomes in servicemen with CECS who were treated at a Military Rehabilitation Center...
November 28, 2017: Military Medical Research
https://www.readbyqxmd.com/read/29449772/differential-examination-diagnosis-and-management-for-tingling-in-toes-fellow-s-case-problem
#9
Cody J Mansfield, Jake Bleacher, Paul Tadak, Matthew S Briggs
Background: The diagnosis of chronic exertional compartment syndrome can be challenging as other pathologies involving bone, muscle, nerve and vascular structures can mimic the syndrome. The purpose of this Fellow's Case Problem is to describe the clinical decision-making and physical therapy differential diagnosis regarding a 25-year-old patient with un-resolved neurovascular complaints following chronic exertional compartment syndrome surgical release. Diagnosis: After surgery, the patient's previous complaint of numbness and tingling in the plantar surfaces of her first and second toes of right foot was still present...
December 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29415981/acute-exertional-compartment-syndrome-with-rhabdomyolysis-case-report-and-review-of-literature
#10
Brandon McKinney, Christopher Gaunder, Ross Schumer
BACKGROUND Acute exertional compartment syndrome (AECS) is a rare cause of leg pain often associated with a delay in diagnosis and potentially leading to irreversible muscle and nerve damage. CASE REPORT We present the case of a previously healthy, high-level athlete who presented with the acute onset of unilateral anterior leg pain and foot drop the day after a strenuous workout. He was diagnosed with compartment syndrome and rhabdomyolysis. His management included emergent fluid resuscitation, fasciotomies, debridement of necrotic muscle from his anterior compartment, and delayed primary closure...
February 8, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29388081/loss-of-angelman-syndrome-protein-e6ap-disrupts-a-novel-antagonistic-estrogen-retinoic-acid-transcriptional-crosstalk-in-neurons
#11
Jimmy El Hokayem, Edwin Weeber, Zafar Nawaz
Angelman syndrome (AS) is a complex genetic disorder that affects the nervous system. AS affects an estimated 1 in 12,000 to 20,000 individuals. Characteristic features of AS includes developmental delay or intellectual disability, severe speech impairment, seizures, small head size (microcephaly), and problems with movement and balance (ataxia). AS individuals usually have microdeletion of the maternal copy of 15q11.2-15q13 region of chromosome 15. The E6-associated protein (E6AP, an E3 ubiquitin protein ligase enzyme) is encoded by the gene UBE3A, which is located in this region, and it has been shown that deregulation of E6AP gives rise to AS and neuropathology of autism spectrum disorders (ASDs) (e...
January 31, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29349018/open-4-compartment-fasciotomy-for-chronic-exertional-compartment-syndrome-of-the-leg
#12
Amos Z Dai, Michael Zacchilli, Neha Jejurikar, Hien Pham, Laith Jazrawi
Chronic exertional compartment syndrome (CECS) is a significant source of lower extremity pain and morbidity in the athletic population. Although endoscopic techniques have been introduced, open fasciotomy remains the mainstay of surgical treatment because of the paucity of evidence in support of an endoscopic approach. The literature on surgical management of CECS is mixed, and overall success rates are modest at best. Optimizing surgical technique, including prevention of neurovascular injury and wound complications, can make a significant impact on the clinical outcome...
December 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29315124/diagnosis-and-treatment-of-chronic-exertional-compartment-syndrome-of-the-forearm-in-motocross-riders
#13
Joseph Humpherys, Zachary Lum, Jondy Cohen
No abstract text is available yet for this article.
January 2018: JBJS Reviews
https://www.readbyqxmd.com/read/29169304/determination-of-the-predictive-clinical-parameters-to-diagnose-chronic-exertional-compartment-syndrome
#14
Alban Fouasson-Chailloux, Pierre Menu, Jérémie Allorent, Marc Dauty
Chronic exertional compartment syndrome (CECS) is characterized by pain occurring during physical activity. As clinical examination is not sufficient to diagnose it, intracompartmental pressure (ICP) measure is used for CECS confirmation. Numerous clinical signs are reported but their diagnosis predictive ability has never been studied. We aimed to determine if the 12 classically reported clinical signs are predictive of CECS. We performed a single-centre retrospective cohort study on patients referred for CECS suspicion...
March 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29164162/functional-outcomes-after-the-surgical-management-of-isolated-anterolateral-leg-chronic-exertional-compartment-syndrome
#15
Grace Gatenby, Samuel Haysom, Bruce Twaddle, Stewart Walsh
Background: Failure rates of up to 20% have been reported after fasciotomy for chronic exertional compartment syndrome (CECS). There is some evidence that postoperative failure and complication rates are higher in the posterior compartments of the lower leg than the anterolateral compartments. Isolated compartment surgery may put patients at risk of requiring revision surgery because of the risk of developing posterior compartment disease. Hypothesis: Isolated anterolateral fasciotomy for CECS, in the absence of posterior compartment symptoms, produces satisfactory functional outcomes...
November 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29126337/factors-predicting-lower-leg-chronic-exertional-compartment-syndrome-in-a-large-population
#16
Johan A de Bruijn, Aniek P M van Zantvoort, David van Klaveren, Michiel B Winkes, Marike van der Cruijsen-Raaijmakers, Adwin R Hoogeveen, Joep A W Teijink, Marc R Scheltinga
Knowledge about lower leg chronic exertional compartment syndrome (CECS) is largely obtained from highly selected populations. Patient characteristics may therefore not be appropriate for the general population. Our purpose was to describe a heterogeneous population of individuals suspected of lower leg CECS and to identify predictors of CECS. Charts of individuals who were analyzed for exercise-induced lower leg pain in a referral center between 2001 and 2013 were retrospectively studied. Patients were included if history and physical examination were suggestive of CECS and if they had undergone a dynamic intracompartmental pressure measurement...
January 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29101975/chronic-exertional-compartment-syndrome-in-athletes
#17
REVIEW
Betty Liu, Gustavo Barrazueta, David E Ruchelsman
Chronic exertional compartment syndrome (CECS) refers to exercise-induced, reversible increases in pressure within well-defined inelastic fascial compartments leading to compromised tissue perfusion followed by functional loss, ischemic pain, and neurologic symptoms. Symptoms typically resolve when the activity ceases and there are usually no permanent sequelae. In the upper extremity, this condition most commonly affects athletes during sports requiring repetitive and vigorous gripping, such as rowers. In addition to clinical history and examination, a number of methods aid diagnosis, including compartment pressure measurements, magnetic resonance imaging, and near infrared spectroscopy...
November 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29059243/muscle-oxygenation-in-type-1-diabetic-and-non-diabetic-patients-with-and-without-chronic-compartment-syndrome
#18
Patrik Gustafsson, Albert G Crenshaw, David Edmundsson, Göran Toolanen, Sead Crnalic
BACKGROUND: Type 1 diabetic patients and non-diabetic patients were referred for evaluation for chronic exertional compartment syndrome (CECS) based on clinical examination and complaints of activity-related leg pain in the region of the tibialis anterior muscle. Previous studies using near-infrared spectroscopy (NIRS) showed greater deoxygenation during exercise for CECS patients versus healthy controls; however, this comparison has not been done for diabetic CECS patients. METHODS: We used NIRS to test for differences in oxygenation kinetics for Type 1 diabetic patients diagnosed with (CECS-diabetics, n = 9) versus diabetic patients without (CON-diabetics, n = 10) leg anterior chronic exertional compartment syndrome...
2017: PloS One
https://www.readbyqxmd.com/read/29035986/long-term-outcome-of-mini-open-surgical-decompression-for-chronic-exertional-compartment-syndrome-of-the-forearm-in-professional-motorcycling-riders
#19
Giorgio Gondolini, Paolo Schiavi, Francesco Pogliacomi, Francesco Ceccarelli, Tommaso Antonetti, Michele Zasa
OBJECTIVE: To evaluate results of mini-open fasciotomy (MOF) in high-level motorcycling or motocross riders with chronic exertional compartment syndrome (CECS) at long-term follow-up (minimum 5 years). DESIGN: Case series. LEVEL OF EVIDENCE: IV. SETTING: University Hospital/Private Practice. PATIENTS: Fifty-four professional motorcycling riders treated with MOF for a CECS of the forearm from January 2006 to June 2011...
October 10, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28985488/plantar-pressure-differences-between-cases-with-symptoms-of-clinically-diagnosed-chronic-exertional-compartment-syndrome-and-asymptomatic-controls
#20
Andrew Roberts, David Hulse, Alexander N Bennett, Sharon Dixon
BACKGROUND: Anterior chronic exertional compartment syndrome of the leg has been hypothesised to develop due to excessive muscle activity and foot pronation. Plantar pressure variables related to lower limb muscle activity and foot type may therefore provide insight into this condition. METHODS: 70 male cases and 70 asymptomatic controls participated. A clinical diagnosis was established from typical symptoms, with clinical examination excluding other pathologies...
December 2017: Clinical Biomechanics
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