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Pancreas transplantation

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https://www.readbyqxmd.com/read/27925870/hydrogen-sulfide-enhances-pancreatic-%C3%AE-cell-differentiation-from-human-tooth-under-normal-and-glucotoxic-conditions
#1
Ioan Valentin Matei, Hisataka Ii, Ken Yaegaki
AIM: Glucotoxicity obstructs pancreatic differentiation from adult stem cells. The aim was to develop a novel protocol for differentiation of dental pulp stem cells (DPSCs) into pancreatic β cells and determine the effect of H2S on glucotoxicity. MATERIALS & METHODS: DPSCs were differentiated with media containing 5.5 or 25.0 mM glucose, exposed to 1 ng/ml H2S. Glucotoxicity, expression of β-cell markers, INS, PDX1 and GLUT2, and PI3K/AKT pathway were assessed...
December 7, 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/27900974/disseminated-mycobacteria-chelonae-infection-in-a-kidney-pancreas-transplant-recipient-a-case-report-and-review-of-the-literature
#2
Shafi Malik, Ananda Ghosh, Shahid Husain
A 40-year-old male with a long-standing history of type 1 diabetes with end-stage renal failure underwent combined kidney-pancreas (KP) transplant from a standard criteria donor. Post-operative course was uncomplicated with good primary function of both transplant grafts. Induction was with thymoglobulin and maintenance immunosuppression was with tacrolimus, mycophenolate mofetil and prednisolone. Nine weeks post-transplant, the patient developed dysfunction of both grafts. Panel reactive antibody testing revealed that the patient had developed a de novo donor-specific antibody and considering an antibody-mediated rejection the patient was treated with intravenous pulse methyl prednisone 500 mg ×3 doses, IV immunoglobulin 2 mg/kg in two divided doses, and ATG 7 mg/kg (total dose of 700 mg)...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27895320/clinical-experience-with-pancreas-graft-rescue-from-severe-thrombus-after-simultaneous-pancreas-kidney-transplantation-by-early-detection-with-doppler-ultrasound-a-case-report
#3
Mitsunobu Takeda, Daisaku Yamada, Hidetoshi Eguchi, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Kunihito Goto, Koichi Kawamoto, Yutaka Takeda, Masahiro Tanemura, Toshinori Ito, Masaki Mori, Yuichiro Doki
BACKGROUND Graft thrombosis is the main cause of early graft loss after transplantation. In Japan, pancreases available for transplantation are frequently from marginal donors due to diverse backgrounds in the population. However, marginal tissues increase the risk of early thrombosis in the graft. CASE REPORT Here, we describe a 41-year-old woman with type 1 diabetes mellitus who underwent a simultaneous pancreas-kidney transplantation. The pancreas was retrieved from a 34-year-old man who had experienced severe hemodynamic instability...
November 29, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27888562/parainfluenza-3-infections-early-after-kidney-or-simultaneous-pancreas-kidney-transplantation
#4
Ilkka Helanterä, Veli-Jukka Anttila, Raisa Loginov, Marko Lempinen
Parainfluenza (PIV) can cause serious infections after hematopoietic stem cell or lung transplantation. Limited data exist about PIV infections after kidney transplantation. We describe an outbreak of PIV-3 in a transplant unit. During the outbreak 45 patients were treated on the ward for postoperative care after kidney or simultaneous pancreas-kidney (SPK) transplantation. Altogether 29 patients were tested for respiratory viruses (12 patients with respiratory symptoms, 17 asymptomatic exposed patients) from nasopharyngeal swabs with PCR...
November 26, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27874968/professionalization-of-surgical-abdominal-organ-recovery-leading-to-an-increase-in-pancreatic-allografts-accepted-for-transplantation-in-the-netherlands-a-serial-analysis
#5
H D Lam, A F Schaapherder, W H Kopp, H Putter, A E Braat, A Baranski
Professional abdominal organ recovery with certification has been mandatory in the Netherlands since 2010. This study analyses the effects of certification (January 2010 - September 2015) on pancreas transplantation and compares it to an era before certification (February 2002 - May 2008) for surgical injuries and the number of pancreases transplanted. A total of 264 cases were analysed. Eighty-four recovered pancreases (31.8%) with surgically injuries were encountered. Forty six of those were surgically salvaged for transplantation, resulting in a total of 226 (85...
November 22, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27864893/high-alcohol-intake-in-deceased-donors-has-no-effect-on-pancreas-graft-survival-a-registry-analysis
#6
R Motallebzadeh, M Aly, M El-Khairi, M Drage, J Olsburgh, C J Callaghan
Outcomes of pancreas transplantation from donors with high alcohol consumption are poorly described. The UK Transplant Registry was used to determine if donor alcohol intake influenced pancreas survival in simultaneous pancreas-kidney (SPK) transplants performed between 2006-2012 (n=770). Recipients were stratified by donor alcohol intake: group I (n=122) - high recent alcohol intake (>21 or >14 units of alcohol/week in males or females, respectively) or previous alcohol abuse; group II (n=648) - low/unknown current intake and no previous alcohol abuse...
November 19, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27862883/the-banff-2015-kidney-meeting-report-current-challenges-in-rejection-classification-and-prospects-for-adopting-molecular-pathology
#7
A Loupy, M Haas, K Solez, L Racusen, D Glotz, D Seron, B J Nankivell, R B Colvin, M Afrouzian, E Akalin, N Alachkar, S Bagnasco, J U Becker, L Cornell, C Drachenberg, D Dragun, H De Kort, I W Gibson, E S Kraus, C Lefaucheur, C Legendre, H Liapis, T Muthukumar, V Nickeleit, B Orandi, W Park, M Rabant, P Randhawa, E F Reed, C Roufosse, S V Seshan, B Sis, H K Singh, C Schinstock, A Tambur, A Zeevi, M Mengel
The XIII. Banff meeting, held in conjunction the Canadian Society of Transplantation in Vancouver, Canada, reviewed the clinical impact of updates of C4d-negative antibody-mediated rejection (ABMR) from the 2013 meeting, reports from active Banff Working Groups, the relationships of donor specific antibody tests (anti-HLA and non-HLA) with transplant histopathology, and questions of molecular transplant diagnostics. The use of transcriptome gene sets, their resultant diagnostic classifiers, or common key genes to supplement the diagnosis and classification of rejection, requires further consensus agreement and validation in biopsies...
November 10, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27849440/use-of-cidofovir-for-cytomegalovirus-disease-refractory-to-ganciclovir-in-solid-organ-recipients
#8
Hugo Bonatti, Costi D Sifri, Clara Larcher, Stefan Schneeberger, Camille Kotton, Christian Geltner
BACKGROUND: Solid organ transplantation (SOT) frequently is complicated by cytomegalovirus (CMV) infections. Cidofovir (CDV) is active against CMV, including many ganciclovir (GCV)-resistant mutants, but often is considered to be too nephrotoxic for use after organ transplantation. PATIENTS AND METHODS: Seven males and two females (median age 50.1 years), including two kidney/pancreas, four lung, one small bowel, and two hand recipients, received CDV for refractory CMV disease...
November 16, 2016: Surgical Infections
https://www.readbyqxmd.com/read/27843954/continuous-quadrupole-magnetic-separation-of-islets-during-digestion-improves-purified-porcine-islet-viability
#9
Bradley P Weegman, Venkata Sunil Kumar Sajja, Thomas M Suszynski, Michael D Rizzari, William E Scott Iii, Jennifer P Kitzmann, Kate R Mueller, Thomas R Hanley, David J Kennedy, Paul W Todd, Appakalai N Balamurugan, Bernhard J Hering, Klearchos K Papas
Islet transplantation (ITx) is an emerging and promising therapy for patients with uncontrolled type 1 diabetes. The islet isolation and purification processes require exposure to extended cold ischemia, warm-enzymatic digestion, mechanical agitation, and use of damaging chemicals for density gradient separation (DG), all of which reduce viable islet yield. In this paper, we describe initial proof-of-concept studies exploring quadrupole magnetic separation (QMS) of islets as an alternative to DG to reduce exposure to these harsh conditions...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27842980/establishment-characterization-and-long-term-culture-of-human-endocrine-pancreas-derived-microvascular-endothelial-cells
#10
Valeria Sordi, Anna Ferri, Valentina Ceserani, Emilio Ciusani, Erica Dugnani, Silvia Pellegrini, Rita Nano, Lorenza Pecciarini, Augusto Pessina, Luisa Pascucci, Lorenzo Piemonti, Giulio Alessandri
BACKGROUND: In vitro primary cultures of microvascular endothelial cells from endocrine pancreas are difficult to obtain, but can be a very helpful tool for studies of islet biology, transplantation and regenerative medicine. METHODS: We applied a protocol recently described for the isolation and culture of brain microvascular endothelial cells (EC) on human pancreatic islets. EC obtained were characterized in terms of morphological (light and transmission electron microscopy), phenotypical (by immunofluorescence and flow cytometry) and functional (cord formation assay and protein secretion by multiplex bead-based assay) characteristics...
November 11, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27836003/adult-human-pancreas-derived-cells-expressing-stage-specific-embryonic-antigen-4-differentiate-into-sox9-expressing-and-ngn3-expressing-pancreatic-ducts-in-vivo
#11
Song Lee, Chan Mi Lee, Song Cheol Kim
BACKGROUND: Tissue-specific stem/progenitor cells are found in various adult tissues and may have the capacity for lineage-specific differentiation, facilitating applications in autologous transplantation. Stage-specific embryonic antigen 4 (SSEA-4), an early embryonic glycolipid antigen, is expressed in cells derived from adult human pancreas exocrine tissue. Here, we examined the characteristics and lineage-specific differentiation capacity of SSEA-4(+) cells. METHODS: Human adult partial pancreas tissues were obtained from different donors and cultured in vitro...
November 11, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27833043/efficient-generation-of-pancreatic-%C3%AE-like-cells-from-the-mouse-gallbladder
#12
Yuhan Wang, Feorillo Galivo, Carl Pelz, Annelise Haft, Jonghyeob Lee, Seung K Kim, Markus Grompe
Direct reprogramming is a promising approach for the replacement of β cells in diabetes. Reprogramming of cells originating from the endodermal lineage, such as acinar cells in the pancreas, liver cells and gallbladder cells has been of particular interest because of their developmental proximity to β cells. Our previous work showed that mouse gallbladder epithelium can be partially reprogrammed in vitro to generate islet-like cells (rGBC1). Here, the reprogramming protocol was substantially improved, yielding cells (rGBC2) closer to functional β cells than the 1st generation method with higher conversion efficiency and insulin expression...
October 27, 2016: Stem Cell Research
https://www.readbyqxmd.com/read/27830180/optimizing-porcine-islet-isolation-to-markedly-reduce-enzyme-consumption-without-sacrificing-islet-yield-or-function
#13
Robert W Holdcraft, Michael L Green, Andrew G Breite, Lisa Circle, Eric D Meyer, Hollie Adkins, Steven G Harbeck, Barry H Smith, Lawrence S Gazda
BACKGROUND: Human allogeneic islet transplantation for treatment of type 1 diabetes provides numerous clinical benefits, such as fewer episodes of hypoglycemic unawareness and tighter control of blood glucose levels. Availability of human pancreas for clinical and research use, however, is severely limited. Porcine pancreas offers an abundant source of tissue for optimization of islet isolation methodology and future clinical transplantation, thereby increasing patient access to this potentially lifesaving procedure...
July 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27823612/islet-cell-transplantation-and-alternative-therapies
#14
REVIEW
Betul Hatipoglu
Even though type 2 diabetes rates plateaued, type 1 diabetes continues to increase. Pancreas transplantation is a treatment modality for patients who suffer hypoglycemic unawareness or complications from diabetes. Islet cell transplantation success rates have improved with modification and advances in isolation, transplantation, and new immunosuppression regimens. The new cell sources as well as delivery ways are explored and being tested in human trials.
December 2016: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/27822401/fatal-donor-derived-carbapenem-resistant-klebsiella-pneumoniae-infection-in-a-combined-kidney-pancreas-transplantation
#15
Giovanni Varotti, Ferdinando Dodi, Anna Marchese, Alessia Terulla, Massimo Bertocchi, Iris Fontana
Carbapenem-resistant Klebsiella pneumoniae (CR-KP) infections in solid organ transplant recipients are associated with high morbidity and mortality. We report a case of a fatal donor-derived CR-KP infection in a combined kidney-pancreas transplant. Given the short interval of time between donor hospitalization and organ procurement, information concerning the donor CR-KP positivity arrived only 72 hours after transplant. Based on this experience, we believe that knowledge of the donor's CR-KP status should be mandatory before procurement and, if positive, pancreas donation should be contraindicated...
2016: Case Reports in Transplantation
https://www.readbyqxmd.com/read/27820783/reply-to-comment-on-the-article-dcd-pancreas-transplantation-meta-analysis-ethical-and-technical-considerations
#16
Sara Shahrestani, Paul Robertson, Henry Pleass, Wayne J Hawthorne
No abstract text is available yet for this article.
November 3, 2016: Transplantation
https://www.readbyqxmd.com/read/27820782/dcd-pancreas-transplantation-meta-analysis-ethical-and-technical-considerations
#17
Anand Sivaprakash Rathnasamy Muthusamy, Peter J Friend, Frank Dor, Jeremy Samuel Crane, Vassilios Papalois, Paul Herbert, Sanjay Sinha
No abstract text is available yet for this article.
November 3, 2016: Transplantation
https://www.readbyqxmd.com/read/27804122/calcineurin-inhibitors-pharmacologic-mechanisms-impacting-both-insulin-resistance-and-insulin-secretion-leading-to-glucose-dysregulation-and-diabetes-mellitus
#18
REVIEW
H A Chakkera, Y Kudva, B Kaplan
Calcineurin inhibitors (CNIs), including tacrolimus and cyclosporine, are immune-modulating agents used in autoimmune disorders, glomerulonephritides, and after transplantation. CNIs are implicated as diabetogenic drugs but the mechanism is not clearly elucidated. Calcineurin is a cytosolic-phosphatase critical for T-lymphocyte activation. Calcineurin is widely distributed in different tissues responsible for glucose-regulation including pancreas, liver, skeletal muscle, adipocytes, brain, and gut. We describe the pharmacologic effects of CNIs in different tissues and impact on glucose regulation...
November 2, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27801416/-evaluation-of-markers-for-renal-graft-dysfunction-in-patients-with-type-1-diabetes-mellitus-after-kidney-transplantation-and-simultaneous-pancreas-kidney-transplantation
#19
A M Glazunova, M S Arutyunova, E V Tarasov, L V Nikankina, A V Il'in, M Sh Shamkhalova, M V Shestakova, Ya G Moisyuk
AIM: To study the markers of renal graft dysfunction in patients with type 1 diabetes mellitus (T1DM) after kidney transplantation (KT) and simultaneous pancreas-kidney transplantation (SPKT). SUBJECTS AND METHODS: The investigation enrolled 20 patients after successful SPKT and 41 patients after KT (of them 21 received continuous subcutaneous insulin infusion with an insulin doser; 20 had multiple insulin injections). The periods after KT and SPKT at patient inclusion were 8 (7; 8) and 11 (8; 18) months, respectively...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27798517/incidence-and-indications-for-late-allograft-pancreatectomy-while-on-continued-immunosuppression
#20
Sandesh Parajuli, Jon Odorico, Brad C Astor, Arjang Djamali, Hans Sollinger, Robert Redfield, Dixon Kaufman, Didier A Mandelbrot
BACKGROUND: There are limited data about the incidence and indications for late allograft pancreatectomy while on continued immunosuppression for functional kidney allografts. METHODS: We analyzed recipients of simultaneous pancreas and kidney (SPK) and pancreas after kidney (PAK) transplants between January 1994 and July 2013. Patients with functional kidney but failed pancreas allografts after 90 days were included. RESULTS: Out of 1022 SPK or PAK recipients, 246 satisfied these criteria...
October 28, 2016: Transplantation
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