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Supatcha Kubglomsong, Chockchai- Theerakulkait, Ralph L Reed, Liping Yang, Claudia S Maier, Jan F Stevens
Rice bran albumin (RBAlb), which showed higher tyrosinase inhibitory activity than other protein fractions, was hydrolyzed with papain to improve the bioactivity. The obtained RBAlb hydrolysate (RBAlbH) was separated into 11 peptide fractions by RP-HPLC. Tyrosinase inhibition and copper chelation activities decreased with increasing retention time of the peptide fractions. RBAlbH fraction 1, which exhibited the greatest activity, contained 13 peptides whose sequences were determined by using LC-MS/MS. Most of the peptide sequences contained features of previously reported tyrosinase inhibitory and metal chelating peptides, especially peptide SSEYYGGEGSSSEQGYYGEG...
July 17, 2018: Journal of Agricultural and Food Chemistry
Hilary E Baldwin, Linda F Stein Gold, Kenneth B Gordon, Jeremy B Green, Craig L Leonardi, Roberta D Sengelmann
Updates on managing some of the most common dermatologic conditions for which patients seek care illuminated presentations at the Skin Disease Education Foundation's 42nd Annual Hawaii Dermatology Seminar®. This educational supplement summarizes the highlights of clinical sessions presented during this CME/CE conference. Treatment of psoriasis has continued to advance, with three interleukin (IL)-17 antagonists approved by the US Food and Drug Administration (FDA) and a fourth in phase 3 trials. An authority on the use of biologics in psoriasis presents current data on the safety and efficacy of these therapies...
June 2018: Seminars in Cutaneous Medicine and Surgery
Sharda Shah Peshin, Y K Gupta
Extensive use of different chemicals in various fields and their easy availability has led to an increased incidence of accidental and intentional poisoning in developing countries including India. A diverse range of household products commonly used for domestic purposes comprise pesticides, household cleaners, thermometer mercury, antiseptics, kerosene, paint thinners etc. Any of these products, if misused or mishandled can cause poisoning. In India, the National Poisons Centre (NPIC) at the All India Institute of Medical Sciences, New Delhi, provides information on management of poisoning to treating physicians...
July 10, 2018: Journal of Forensic and Legal Medicine
Laure-Alix Clerbaux, Sandra Coecke, Annie Lumen, Tomas Kliment, Andrew P Worth, Alicia Paini
Costs, scientific and ethical concerns related to animal tests for regulatory decision-making have stimulated the development of alternative methods. When applying alternative approaches, kinetics have been identified as a key element to consider. Membrane transporters affect the kinetic processes of absorption, distribution, metabolism and excretion (ADME) of various compounds, such as drugs or environmental chemicals. Therefore, pharmaceutical scientists have intensively studied transporters impacting drug efficacy and safety...
July 13, 2018: Science of the Total Environment
Lan Feng, Nannan Shi, Shasha Cai, Xue Qiao, Peng Chu, Hui Wang, Feida Long, Huaixin Yang, Yongliang Yang, Yipeng Wang, Haining Yu
Cutaneous hyperpigmentation from excess melanogenesis causes serious pigmentary disorders and even melasma. Short peptides (SPs) are garnering attention lately owing to their therapeutic potential in dermatological diseases and low systemic side-effects. Here, we show an octapeptide, Ansin2, de novo designed from antioxidant SPs we previously reported, significantly inhibited the melanogenesis in B16 cells by decreasing the tyrosinase production via regulating MITF pathway. Ansin2 could also inhibit the tyrosinase function by covering its catalytic pocket, simulated by docking and LIGPLOT studies...
July 16, 2018: Journal of Medicinal Chemistry
Asma Beltifa, Afifa Belaid, Vincenzo Lo Turco, Monia Machreki, Hedi Ben Mansour, Giuseppa Di Bella
In this study, 18 plasticizer (phthalates, adipates, sebacates, and others) and BPA residues in some cosmetic samples collected from Tunisian market are evaluated by micro-matrix solid-phase dispersion combined with GC-MS. In parallel, the impact of these molecules and the cosmetics in the human epithelial cell lines is investigated. The cytotoxic activity of cosmetic extracts is evaluated in vitro against B16 and Hep-2 human skin cell lines using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay...
July 16, 2018: International Journal of Environmental Health Research
Rosa A Fernandes, Luís Santiago, Miguel Gouveia, Margarida Gonçalo
BACKGROUND: Panthenol (synonym: dexpanthenol), the alcohol analogue of panthothenic acid, is frequently included in moisturizers, wound-healing agents, and other cosmetics, and has been shown to be responsible for allergic contact dermatitis (ACD). OBJECTIVES: To evaluate the frequency of ACD caused by dexpanthenol, and to characterize reactive patients. METHODS: We retrospectively reviewed the files of patients patch tested between 2009 and 2017 in the Department of Dermatology of the Coimbra's University Hospital and describe patients who reacted to dexpanthenol 5% pet...
July 16, 2018: Contact Dermatitis
Friedel Boucneau, An Goossens, Sara Huygens, Liesbeth Gilissen
No abstract text is available yet for this article.
July 16, 2018: Contact Dermatitis
Sara Silva, Pedro Lage, Francisco Cabral, Rui Alves, Ana Catarino, Ana Félix, Saudade André
Breast fibromatosis is a benign fibroblastic proliferation accounting for less than 0.2% of breast tumors. It presents sporadically or as a manifestation of familial adenomatous polyposis (FAP). Fibromatosis in FAP may develop in patients with adenomatous polyposis coli ( APC ) gene mutations at any location through the gene. Notably, there is an increased risk if mutation is downstream codon 1400. The present case report described a 33-year-old woman with recurrent bilateral breast fibromatosis after breast implants in a context of classic FAP...
August 2018: Oncology Letters
Ashok Keshav Rathod, Rakesh Padmakar Dhake, Mohit Navinchand Muttha, Amit Indrasan Singh, Dattatray Vilas Thakur
Objective/Purpose: The objective of this study is to describe our experience with the use of stay sutures and transverse neck incision for anterior cervical spine surgeries involving multiple levels. Summary of Background Data: Transverse incisions on neck usually heal with minimal fibrosis resulting in cosmetically acceptable scars whereas vertical incision, although provides greater exposure, heals with extensive fibrosis resulting in ugly scars. Transverse incision is thus highly recommended...
April 2018: Journal of Craniovertebral Junction and Spine
Idha Kusumawati, Kresma Oky Kurniawan, Subhan Rullyansyah, Tri Anggono Prijo, Retno Widyowati, Juni Ekowati, Eka Pramyrtha Hestianah, Suprapto Maat, Katsuyoshi Matsunami
ETHNOPHARMACOLOGICAL RELEVANCE: Temu giring, the rhizome of Curcuma heyneana Valeton & Zipj (C. heyneana), is native to tropical regions, especially in Indonesia. It is traditionally used as a skin care, for cosmetic and body freshness, in Javanese and Balinese women, and has many other bioactivities such as antioxidant, anticancer and antiinflammatory. AIM OF THE STUDY: The purpose of this study was to determine the antiaging activity of C. heyneana to prove its traditional use...
July 3, 2018: Journal of Ethnopharmacology
Rajnish Kaur, Deepak Kukkar, Sanjeev K Bhardwaj, Ki-Hyun Kim, Akash Deep
The use of fragrances is often essential to create an elegant, welcoming, or exhilarating environment. Through encapsulation, the release and delivery of fragrances are customized in many consumer products. For such purposes, cost-effective techniques have been developed and employed with the use of various polymers and porous organic materials to efficiently impart fragrances to foods and various other consumer products. After entrapment or uptake/storage of fragrant molecules within a polymeric complex, the properties can be investigated by automated thermal desorption (ATD) analysis...
July 7, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
L X Ngui, I P Tang
OBJECTIVES: To investigate the surgical and audiological outcomes of the Bonebridge transcutaneous bone conduction hearing implant among children with congenital aural atresia. METHODS: Six children were recruited and underwent Bonebridge transcutaneous bone conduction implant surgery. The patients' audiometric thresholds for air conduction, bone conduction and sound-field tests were assessed pre-operatively and at six months post-operatively. Patients' satisfaction was assessed at six months post-operatively with the Hearing Device Satisfaction Scale...
July 16, 2018: Journal of Laryngology and Otology
Djaceli Sampaio de Oliveira Dembogurski, Danielle Silva Trentin, Amanda Galdi Boaretto, Graziela Vargas Rigo, Rodrigo Campos da Silva, Tiana Tasca, Alexandre José Macedo, Carlos Alexandre Carollo, Denise Brentan Silva
Propolis, a resin produced by bees, is widely used in industrial products, including food, cosmetics, supplements, and pharmaceuticals. Extracts (ethanolic and hydroethanolic) and fractions, yielded by accelerated solvent extraction methodology, were obtained from different samples of Brazilian brown propolis (BBP). They were evaluated for antioxidant capacity, antibacterial, antibiofilm, and anti-Trichomonas vaginalis activities. The metabolomics profiling was determined by LC-DAD-MS and an innovative application of statistical analyses (univariate and chemometrics) was applied to correlate chemical compounds with biological activities...
September 2018: Food Research International
Rouffet Alban, Florczak Anne Sophie, Vimont Thibault, Deranque Clément, Boucher Sophie, Rousseau Pascal
OBJECTIVE: The risk of sight-threatening complications related to facial paralysis makes palpebral fissure management a priority. Surgery must take account of and adapt to the clinical signs of paralytic lagophthalmos. This therefore presupposes that a sufficient therapeutic arsenal is available. In this report, we propose a technique for palpebral lengthening (lower and/or upper), reconstructing the posterior lamella using a chondromucosal graft harvested from the nasal septum, combined with anterior lamellar repositioning...
June 5, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
Stephanie E Dreifuss, Danielle Minteer, Beth R Gusenoff, Jeffrey A Gusenoff
Background: Pedal fat grafting is a cosmetic procedure indicated to treat the functional and aesthetic sequelae of pedal fat pad atrophy. Fat grafting has been found to mitigate these symptoms, but the exact mechanism is unknown. Objectives: We hypothesize that pedal fat grafting may improve skin quality, accounting for prolonged symptomatic improvement despite loss of grafted fat. Methods: Patients with pedal atrophy were enrolled in a randomized crossover clinical trial...
July 10, 2018: Aesthetic Surgery Journal
Leandro Chambrone, Giovan Paolo Pini Prato
The demand for cosmetic medical treatments has increased markedly over the past few years. In Periodontology, the treatment of gingival recessions (GR), especially on anterior teeth, is being requested more and more frequently, and patient expectations are very high. This article is protected by copyright. All rights reserved.
July 14, 2018: Journal of Periodontology
Wilai Thanasarnaksorn, Sebastian Cotofana, Christina Rudolph, Patcharahatai Kraisak, Nongsak Chanasumon, Atchima Suwanchinda
Hyaluronic acid (HA) injection is a popular nonsurgical, facial rejuvenating procedure. Due to the rapidly expanding use of HA injections, significant potential complications have also increased in frequency. Among these complications, the rare but most devastating one is arterial occlusion, which can result in skin necrosis or blindness. To describe the mechanisms behind vision loss secondary to hyaluronic acid injection and the efficacy of treatments to restore vision and associated ocular functionality. We reviewed six cases of patients from October 2011 to December 2017 who experienced vision loss after receiving facial HA injections and the subsequent treatments undertaken to attempt to reverse the vision loss and additional eye complications...
July 13, 2018: Journal of Cosmetic Dermatology
Gabriela Meireles, Michiel A Daam, Ana Letícia Madeira Sanches, Maria V B Zanoni, Amadeu M V M Soares, Carlos Gravato, Danielle P de Oliveira
Dyes have been used for more than twenty thousand years in textile, pharmaceutical, food, cosmetic, and photographic industries, among others. Despite their importance in these applications, dyes can be toxic and resistant to many degradation processes used in wastewater treatment plants. Although a large number of dyes have been released in the environments in high amounts, studies into the environmental toxicity of these substances are still scarce. The aim of this study was to evaluate the potential toxic effects of textile dyes Disperse Red 60, Disperse Red 73 and Disperse Red 78 in zebrafish early life stages...
July 10, 2018: Chemico-biological Interactions
Yu Gabe, Akimitsu Miyaji, Masahiro Kohno, Akira Hachiya, Shigeru Moriwaki, Toshihide Baba
BACKGROUND: Rhododendrol (4-(4-hydroxyphenyl)-2-butanol) has been used as a lightening/whitening cosmetic but was recently reported to induce leukoderma. Although rhododendrol has been shown to be transformed by tyrosinase to hydroxyl-rhododendrol, which is cytotoxic to melanocytes, its detailed mechanism of action including the involvement of reactive oxygen species is not clearly understood. OBJECTIVE: To confirm the relationship of hydroxyl radical generation to melanocyte cytotoxicity induced by rhododendrol, this study was performed...
June 27, 2018: Journal of Dermatological Science
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