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https://www.readbyqxmd.com/read/28214915/evaluation-of-the-gard-assay-in-a-blind-cosmetics-europe-study
#1
Henrik Johansson, Robin Gradin, Andy Forreryd, Maria Agemark, Kathrin Zeller, Angelica Johansson, Olivia Larne, Erwin van Vliet, Carl Borrebaeck, Malin Lindstedt
Chemical hypersensitivity is an immunological response towards foreign substances, commonly referred to as sensitizers, which gives rise primarily to the clinical symptoms known as allergic contact dermatitis. For the purpose of mitigating risks associated with consumer products, chemicals are screened for sensitizing effects. Historically, such predictive screenings have been performed using animal models. However, due to industrial and regulatory demand, animal models for the purpose of sensitization assessment are being replaced by animal-free testing methods, a global trend that is spreading across industries and market segments...
February 17, 2017: ALTEX
https://www.readbyqxmd.com/read/28214585/preparation-and-biocompatibility-of-a-chitin-nanofiber-gelatin-composite-film
#2
Yoko Ogawa, Kazuo Azuma, Hironori Izawa, Minoru Morimoto, Kosuke Ochi, Tomohiro Osaki, Norihiko Ito, Yoshiharu Okamoto, Hiroyuki Saimoto, Shinsuke Ifuku
The development of chitin-based materials with favorable mechanical properties and biocompatibility is an important research goal owing to the wide-ranging practical applications. In this study, a composite film was prepared using chitin nanofibers and gelatin. The CNF/gelatin composite film was highly viscous and had a fine nanofiber structure. The transmittances indicated high transparency, regardless of nanofiber content. The water content of the CNF/gelatin composite film increased linearly as the gelatin content increased...
February 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28213845/topical-formulation-containing-beeswax-based-nanoparticles-improved-in-vivo-skin-barrier-function
#3
Carla Souza, Luis Alexandre Pedro de Freitas, Patrícia Maria Berardo Gonçalves Maia Campos
Lipid nanoparticles have shown many advantages for treatment/prevention of skin disorders with damaged skin barrier function. Beeswax is a favorable candidate for the development of nanosystems in the cosmetic and dermatological fields because of its advantages for the development of products for topical application. In the present study, beeswax-based nanoparticles (BNs) were prepared using the hot melt microemulsion technique and incorporated to a gel-cream formulation. The formulation was subsequently evaluated for its rheological stability and effect on stratum corneum water content (SCWC) and transepidermal water loss (TEWL) using in vivo biophysical techniques...
February 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28213263/determination-of-n-nitrosodiethanolamine-in-cosmetic-products-by-reversed-phase-dispersive-liquid-liquid-microextraction-followed-by-liquid-chromatography
#4
Alberto Chisvert, Juan L Benedé, María Peiró, Isabel Pedrón, Amparo Salvador
A new analytical method for the determination of N-nitrosodiethanolamine (NDELA), a very harmful compound not allowed in cosmetic products, is presented. The method is based on a new approach of dispersive liquid-liquid microextraction (DLLME) useful for extraction of highly polar compounds, called reversed-phase DLLME (RP-DLLME), followed by liquid chromatography-ultraviolet/visible (LC-UV/Vis) determination. The variables involved in the RP-DLLME process were studied to provide the best enrichment factors...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213175/quantitative-analysis-of-mycosporine-like-amino-acids-in-marine-algae-by-capillary-electrophoresis-with-diode-array-detection
#5
Anja Hartmann, Adele Murauer, Markus Ganzera
Marine species have evolved a variety of physical or chemical strategies to diminish damage from elevated environmental ultraviolet radiation. Mycosporine-like amino acids, a group of widely distributed small water soluble compounds, are biologically relevant because of their photo-protective potential. In addition, presumed antioxidant and skin protective strategies raise the interest for possible medicinal and cosmetic applications. In this study the first CE method for the quantification of mycosporine-like amino acids in marine species is presented...
February 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28212686/validity-of-a-simplified-screening-instrument-for-assessing-overweight-children-in-a-dental-setting-a-cross-sectional-study
#6
Amir Azarpazhooh, Anoushe Sekhavat, Michael J Sigal
BACKGROUND: Obesity, with its rising prevalence among Canadians and its estimated cost of $2 billion annually in Canada, is no longer considered a cosmetic issue, but a major health issue that imposes a great burden on the healthcare system and economy. This cross sectional study aims to evaluate the feasibility of identifying the weight status of 6 to 11 year-old children in a university dental clinic using a simplified overweight screening instrument. METHODS: One hundred sixty eight healthy children were enrolled...
February 17, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28212329/enzyme-assisted-discovery-of-antioxidant-peptides-from-edible-marine-invertebrates-a-review
#7
REVIEW
Tsun-Thai Chai, Yew-Chye Law, Fai-Chu Wong, Se-Kwon Kim
Marine invertebrates, such as oysters, mussels, clams, scallop, jellyfishes, squids, prawns, sea cucumbers and sea squirts, are consumed as foods. These edible marine invertebrates are sources of potent bioactive peptides. The last two decades have seen a surge of interest in the discovery of antioxidant peptides from edible marine invertebrates. Enzymatic hydrolysis is an efficient strategy commonly used for releasing antioxidant peptides from food proteins. A growing number of antioxidant peptide sequences have been identified from the enzymatic hydrolysates of edible marine invertebrates...
February 16, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28211877/fresh-frozen-amniotic-membrane-for-conjunctival-reconstruction-after-excision-of-neoplastic-and-presumed-neoplastic-conjunctival-lesions
#8
U Agraval, P Rundle, I G Rennie, S Salvi
PurposeSuspicious neoplastic conjunctival lesions often require wide excision with tumour-free margins, leaving significant conjunctival defects requiring reconstruction. In this study we report the results of using fresh frozen amniotic membrane grafts (AMG) after wide excision of potentially malignant lesions.MethodsRetrospective review of 53 patients; between January 2011 and April 2014. Conjunctival lesions were excised with a non-touch technique (2 mm margin) and sent for histopathological analysis. The surgical margins were treated with cryotherapy and a fresh frozen AMG was used to cover the defect...
February 17, 2017: Eye
https://www.readbyqxmd.com/read/28211326/evaluation-of-in%C3%A2-vivo-and-in%C3%A2-vitro-toxicological-and-genotoxic-potential-of-aluminum-chloride
#9
Letícia Nazareth Fernandes Paz, Laís Mesquita Moura, Danielle Cristinne A Feio, Mirella de Souza Gonçalves Cardoso, Wagner Luiz O Ximenes, Raquel C Montenegro, Ana Paula N Alves, Rommel R Burbano, Patrícia Danielle L Lima
Aluminum and its compounds are common contaminants of water and food, as well as medications and cosmetics. The wide distribution of the element facilitates the demand for detailed studies of its biological and toxicological effects. This work aimed to evaluate the possible genotoxic and toxic activity resulting from in vivo and in vitro exposure to Al. For in vivo analysis, 40 Swiss mice were used, various concentrations of hydrated aluminum chloride were administered orally. They were analyzed for possible genic activity and metal cytotoxicity using a micronucleus test (MN), and for toxicity through histopathological evaluation of the extracted organs...
February 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28210398/injection-adipolysis-mechanisms-agents-and-future-directions
#10
REVIEW
Shahraam Kamalpour, Keith Leblanc
Noninvasive procedures targeting the elimination of unwanted adipose tissues have recently been developed. injection adipolysis is the term for the injection of cytotoxic substances into these tissues, with the intent of cosmetic improvement by volume reduction. initial attempts in the field utilized intravenous preparations of sodium deoxycholate and soy-derived phosphatidylcholine, approved for the intravenous treatment of fat emboli and dyslipidemias in countries outside the United States. it was initially purported that the active ingredient in these injections was phosphatidylcholine...
December 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28210397/nonsurgical-cosmetic-procedures-for-men-trends-and-technique-considerations
#11
REVIEW
Corey S Frucht, Arisa E Ortiz
Once sought nearly exclusively by women, nonsurgical cosmetic procedures are increasingly being sought after by men. Reviewed here are survey data that characterize the spectrum of nonsurgical cosmetic procedures men are preferentially utilizing, the percentage of nonsurgical cosmetic procedures consumers who are men, and how some of these figures are changing with time. while men still comprise a small minority (approximately 10-20%) of those pursuing nonsurgical cosmetic procedures, this sector is growing, in particular for injection of neurotoxins...
December 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28210386/ionic-hydrogel-monotherapy-and-in-combination-with-antiviral-antibiotic-prophylaxis-in-the-post-procedure-management-of-fractional-laser-treated-patients
#12
Francesca Romana Grippaudo
Objective: The pre- and postoperative care for fractionated laser resurfacing is still controversial, especially in regard to the use of antibiotics to prevent bacterial infection and potential consequences. Recently, an ionic hydrogel has shown to be useful in the postoperative treatment of minor burns. The aim of this study is to evaluate the use of this hydrogel after fractional laser treatments targeting photoaging and chronoaging damage to skin. Design: A randomized prospective study. Setting: one plastic surgeon private practice...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28210385/high-dose-rate-electronic-brachytherapy-a-nonsurgical-treatment-alternative-for-nonmelanoma-skin-cancer
#13
REVIEW
Ajay Bhatnagar, Rakesh Patel, William Philip Werschler, Roger I Ceilley, Robert Strimling
The authors summarized data from a group of physicians with experience using high-dose rate electronic brachytherapy for the treatment of nonmelanoma skin cancer. The data have been published or presented in abstract format at national dermatology and radiation oncology meetings. The data included 1,822 treated lesions from 2009 to 2014 in patients ranging in age from 52 to 104 years. Most lesions were basal cell carcinoma (57%) or squamous cell carcinoma (38%) less than 2cm in size (97%). Median follow-up at the various centers ranged from 4 to 16 months, and results yielded an extremely low recurrence rate of less than one percent...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28208954/effect-of-surgical-curve-correction-on-exercise-tolerance-and-physical-capacities-in-patients-of-severe-spinal-deformity
#14
Prateek C Patil, Ashok K Rathod, Mandar Borde, Vishwajeet Singh, Hemant U Singh
INTRODUCTION: Traditionally, surgical intervention for patients with a spinal deformity has been considered for cosmetic benefits, but surgical intervention can alter the lung physiology or volumes and in turn leads to increase in physical capacity and exercise tolerance. Therefore, we conducted this to determine whether a surgical correction would restore the lung physiology, physical capacity and exercise tolerance in patients with kyphoscoliosis. AIM: To evaluate the usage of six-minute walk test scores and modified Borg scores as tools/measures for exercise tolerance in patients with spinal deformity and to study the effects of surgical correction of spinal deformity on exercise tolerance with above parameters as the measures...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208953/open-reduction-and-volar-plate-fixation-of-dorsally-displaced-distal-radius-fractures-a-prospective-study-of-functional-and-radiological-outcomes
#15
Arjun Ballal, Anand Kumar Sadasivan, Anoop Hegde, Ashwin Shetty
INTRODUCTION: The fractures of the distal radius have always posed a unique challenge to the orthopaedic fraternity. The complex ligamentous and bony anatomy offers a wide variety of fractures to be dealt with around this zone. Over the years these injuries have become common especially in the elderly age group as well as the implants and surgical techniques have improved. AIM: To assess the radiological and functional outcome after fixation of intra-articular dorsally displaced distal radius fractures with open reduction and volar Locking Compression Plate fixation (LCP)...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208818/hydroxycinnamic-acids-and-their-derivatives-cosmeceutical-significance-challenges-and-future-perspectives-a-review
#16
Oludemi Taofiq, Ana M González-Paramás, Maria Filomena Barreiro, Isabel C F R Ferreira
Bioactive compounds from natural sources, due to their widely-recognized benefits, have been exploited as cosmeceutical ingredients. Among them, phenolic acids emerge with a very interesting potential. In this context, this review analyzes hydroxycinnamic acids and their derivatives as multifunctional ingredients for topical application, as well as the limitations associated with their use in cosmetic formulations. Hydroxycinnamic acids and their derivatives display antioxidant, anti-collagenase, anti-inflammatory, antimicrobial and anti-tyrosinase activities, as well as ultraviolet (UV) protective effects, suggesting that they can be exploited as anti-aging and anti-inflammatory agents, preservatives and hyperpigmentation-correcting ingredients...
February 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28208728/parabens-accelerate-ovarian-dysfunction-in-a-4-vinylcyclohexene-diepoxide-induced-ovarian-failure-model
#17
Jae-Hwan Lee, Myeongho Lee, Changhwan Ahn, Hee Young Kang, Dinh Nam Tran, Eui-Bae Jeung
Parabens are widely used preservatives in basic necessities such as cosmetic and pharmaceutical products. In previous studies, xenoestrogenic actions of parabens were reported in an immature rat model and a rat pituitary cell line (GH3 cells). The relationship between parabens and ovarian failure has not been described. In the present study, the influence of parabens on ovarian folliculogenesis and steroidogenesis was investigated. A disruptor of ovarian small pre-antral follicles, 4-vinylcyclohexene diepoxide (VCD, 40 mg/kg), was used to induce premature ovarian failure (POF)...
February 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28208242/chemiluminescence-of-lucigenin-allantoin-and-its-application-for-the-detection-of-allantoin
#18
Muhammad Saqib, Baohua Lou, Mohamed Ibrahim Halawa, Shimeles Addisu Kitte, Zhongyuan Liu, Guobao Xu
Allantoin has been reported as a promising biomarker for monitoring of oxidative stress in humans and widely utilized in a variety of topical pharmaceuticals and cosmetics. Currently, the detection of allantoin is achieved by using chromatographic coupled techniques, which needs sample pre-extraction, derivatization, complex matrixes, and expensive instrumentation. Herein we report both the intense chemiluminescence of allantoin with lucigenin and the chemiluminescent detection of allantoin for the first time...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28208179/a-quantitative-approach-to-determining-the-ideal-female-lip-aesthetic-and-its-effect-on-facial-attractiveness
#19
Natalie A Popenko, Prem B Tripathi, Zlatko Devcic, Koohyar Karimi, Kathryn Osann, Brian J F Wong
Importance: Aesthetic proportions of the lips and their effect on facial attractiveness are poorly defined. Established guidelines would aid practitioners in achieving optimal aesthetic outcomes during cosmetic augmentation. Objective: To assess the most attractive lip dimensions of white women based on attractiveness ranking of surface area, ratio of upper to lower lip, and dimensions of the lip surface area relative to the lower third of the face. Design, Setting, and Participants: In phase 1 of this study, synthetic morph frontal digital images of the faces of 20 white women ages 18 to 25 years old were used to generate 5 varied lip surface areas for each face...
February 16, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28207466/the-subunit-principle-in-scar-face-revision
#20
Ahmed Elshahat, Riham Lashin
Facial scaring is considered one of the most difficult cosmetic problems for any plastic surgeon to solve. The condition is more difficult if the direction of the scar is not parallel to relaxed skin tension lines. Attempts to manage this difficult situation included revisions using geometric designs, Z plasties or W plasties to camouflage the straight line visible scaring. The use of long-lasting resorbable sutures was tried too. Recently, the use of botulinum toxin during revision improved the results. Fractional CO2 lasers, microfat grafts, and platelet-rich plasma were added to the armamentarium...
February 15, 2017: Journal of Craniofacial Surgery
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