Daqian Zhou, Yongliang Mei, Chao Song, Kang Cheng, Weiye Cai, Daru Guo, Silong Gao, Jiale Lv, Tao Liu, Yang Zhou, Liquan Wang, Bing Liu, Zongchao Liu
Intervertebral disc degeneration (IVDD) is a common chronic orthopaedic disease in orthopaedics that imposes a heavy economic burden on people and society. Although it is well established that IVDD is associated with genetic susceptibility, ageing and obesity, its pathogenesis remains incompletely understood. Previously, IVDD was thought to occur because of excessive mechanical loading leading to destruction of nucleus pulposus cells (NPCs), but studies have shown that IVDD is a much more complex process associated with inflammation, metabolic factors and NPCs death and can involve all parts of the disc, characterized by causing NPCs death and extracellular matrix (ECM) degradation...
April 17, 2024: European Journal of Clinical Investigation