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https://www.readbyqxmd.com/read/28046730/su-f-j-07-evaluating-the-adequacy-of-biopsy-specimens-for-genetic-signature-assessment-by-measuring-the-metabolic-activity-in-specimens-obtained-under-18f-fdg-pet-ct-guidance
#1
L Fanchon, J Russell, S Dogan, S Carlin, K Pinker-Domenig, E Yorke, C Ross Schmidtlein, S Fujisawa, K Manova-Todorova, P Zanzonico, J O Deasy, J L Humm, S Solomon, A S Kirov
PURPOSE: Genetic profiling of biopsied tissue is the basis for personalized cancer therapy. However biopsied materials may not contain sufficient amounts of DNA needed for analysis. We propose a method to determine the adequacy of specimens for performing genetic profiling by quantifying metabolic activity. METHODS: We measured the response of two radiation detectors to the activity contained in the minimum amount of tumor cells needed for genetic profiling in biopsy specimens obtained under 2-deoxy-2-((18) F)fluoro-D-glucose ((18) F-FDG) PET/CT guidance...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046308/su-d-207b-05-robust-intra-tumor-partitioning-to-identify-high-risk-subregions-for-prognosis-in-lung-cancer
#2
J Wu, M Gensheimer, X Dong, D Rubin, S Napel, M Diehn, B Loo, R Li
PURPOSE: To develop an intra-tumor partitioning framework for identifying high-risk subregions from 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and CT imaging, and to test whether tumor burden associated with the high-risk subregions is prognostic of outcomes in lung cancer. METHODS: In this institutional review board-approved retrospective study, we analyzed the pre-treatment FDG-PET and CT scans of 44 lung cancer patients treated with radiotherapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28029314/on-the-cutoff-of-baseline-total-metabolic-tumor-volume-in-high-tumor-burden-follicular-lymphoma
#3
Eric Laffon, Roger Marthan
No abstract text is available yet for this article.
December 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27993480/bokhman-redux-endometrial-cancer-types-in-the-21st-century
#4
Adrian A Suarez, Ashley S Felix, David E Cohn
In 1983 Jan V. Bokhman, M.D. published a landmark paper entitled "Two Pathogenetic Types of Endometrial Carcinoma" in which an enduring dualistic view of endometrial cancer was first proposed. "Type I" cancers are thought to represent estrogen driven mostly low grade endometrioid tumors strongly associated with obesity and other components of the metabolic syndrome. "Type II" cancers represent higher grade non-endometrioid tumors for which the latter associations are less significant. Basic tenets of this dichotomy including significant prognostic differences have been abundantly confirmed by later literature...
December 16, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27981471/metabolic-tumor-burden-assessed-by-dual-time-point-18-f-fdg-pet-ct-in-locally-advanced-breast-cancer-relation-with-tumor-biology
#5
Ana María Garcia-Vicente, Julián Pérez-Beteta, Víctor Manuel Pérez-García, David Molina, German Andrés Jiménez-Londoño, Angel Soriano-Castrejón, Alicia Martínez-González
PURPOSE: The aim of the study was to investigate the influence of dual time point 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) positron emission tomography/x-ray computed tomography (PET/CT) on the standard uptake value (SUV) and volume-based metabolic variables of breast lesions and their relation with biological characteristics and molecular phenotypes. PROCEDURES: Retrospective analysis including 67 patients with locally advanced breast cancer (LABC). All patients underwent a dual time point [(18)F]FDG PET/CT, 1 h (PET-1) and 3 h (PET-2) after [(18)F]FDG administration...
December 15, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27977537/pretreatment-metabolic-parameters-measured-by-18f-fdg-pet-to-predict-the-outcome-of-first-line-chemotherapy-in-extensive-stage-small-cell-lung-cancer
#6
Xiaozhou Yu, Yanjia Zhu, Jian Wang, Xiuyu Song, Lei Zhu, Xiaoyuan Men, Xiaofeng Li, Dong Dai, Wengui Xu
OBJECTIVE: Patients' pretreatment metabolic burden, as measured by radiotracer fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT), has been shown to predict treatment outcome in various malignancies. However, its predictive role in extensive-stage small cell lung cancer (SCLC) has not been definitively determined. This retrospective study investigated the viability of using common pretreatment metabolic parameters, obtained through F-FDG-PET/CT, to predict outcomes of first-line chemotherapy in extensive-stage SCLC...
December 13, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27863565/molecular-imaging-and-precision-medicine-in-breast-cancer
#7
REVIEW
Amy V Chudgar, David A Mankoff
Precision medicine, basing treatment approaches on patient traits and specific molecular features of disease processes, has an important role in the management of patients with breast cancer as targeted therapies continue to improve. PET imaging offers noninvasive information that is complementary to traditional tissue biomarkers, including information about tumor burden, tumor metabolism, receptor status, and proliferation. Several PET agents that image breast cancer receptors can visually demonstrate the extent and heterogeneity of receptor-positive disease and help predict which tumors are likely to respond to targeted treatments...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27856630/a-prospective-clinical-trial-of-18f-fluciclovine-pet-ct-neoadjuvant-therapy-response-in-invasive-ductal-and-invasive-lobular-breast-cancers
#8
Gary A Ulaner, Debra Goldman, Adriana Corben, Serge Lyashchenko, Mithat Gonen, Jason Lewis, Maura Dickler
: Fluorine-18-labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid ((18)F-Fluciclovine) is a leucine analog radiotracer that depicts amino acid transport into cells. (18)F-Fluciclovine PET/CT visualizes malignancy including prostate cancer, invasive ductal breast cancer (IDC) and invasive lobular breast cancers (ILC). It has not been shown whether changes in (18)F-Fluciclovine avidity reflect changes in tumor burden resulting from treatment. This prospective clinical trial evaluates changes in (18)F-Fluciclovine-avidity compared to breast cancer therapy response, as determined by residual tumor burden on pathology...
November 17, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27852646/metabolic-reprogramming-by-folate-restriction-leads-to-a-less-aggressive-cancer-phenotype
#9
Zahra Ashkavand, Ciara O'Flanagan, Mirko Hennig, Xiuxia Du, Stephen D Hursting, Sergey A Krupenko
: Folate coenzymes are involved in biochemical reactions of one-carbon transfer, and deficiency of this vitamin impairs cellular proliferation, migration and survival in many cell types. Here the effect of folate restriction on mammary cancer was evaluated using three distinct breast cancer subtypes differing in their aggressiveness and metastatic potential: non-invasive basal-like (E-Wnt), invasive but minimally metastatic claudin-low (M-Wnt), and highly metastatic claudin-low (metM-Wntliver) cell lines, each derived from the same pool of MMTV-Wnt-1 transgenic mouse mammary tumors...
November 16, 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27828693/a-register-based-case-control-study-of-prescription-medication-utilization-in-binge-eating-disorder
#10
Hunna J Watson, Andreas Jangmo, Melissa A Munn-Chernoff, Laura M Thornton, Elisabeth Welch, Camilla Wiklund, Yvonne von Hausswolff-Juhlin, Claes Norring, Barry K Herman, Henrik Larsson, Cynthia M Bulik
OBJECTIVE: Individuals with binge-eating disorder (BED) experience psychiatric and somatic comorbidities and obesity, but the nature and magnitude of prescription medication utilization is unclear. We investigated utilization using Swedish registry data and a case-control design. METHODS: Cases were identified from Riksät and Stepwise longitudinal registers and were individuals diagnosed with BED per DSM-IV-TR criteria between July 1, 2006, and December 31, 2009, at eating disorder clinics (n = 238, 96% female, mean age = 22...
July 7, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27821270/bipolar-disorder-moderates-associations-between-linoleic-acid-and-markers-of-inflammation
#11
Ya-Wen Chang, Shervin Assari, Alan R Prossin, Laura Stertz, Melvin G McInnis, Simon J Evans
Dietary polyunsaturated fatty acids (PUFA) and inflammatory proteins associate with immune activation and have been implicated in the pathophysiology of mood disorders. We have previously reported that individuals with bipolar disorder (BPD) have decreased PUFA intake, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA); and decreased PUFA concentration of plasma EPA and linoleic acid (LA). We have also reported an association between plasma LA and its metabolites and burden of disease measures in BPD...
February 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27817236/-incidence-of-hepatocellular-carcinoma-and-consequent-lessons-for-its-management-in-northeastern-hungary
#12
Renáta Papp, Mária Papp, István Tornai, Zsuzsanna Vitális
INTRODUCTION: The increasing incidence and poor prognosis of hepatocellular carcinoma places huge burden on healthcare. AIM: After reviewing literature on epidemiological trends, risk factors, diagnosis and management options for hepatocellular carcinoma, the authors investigated results of treatment and survival data of patients in Northeastern Hungary. METHOD: In a retrospective study, the authors analyzed medical records of 187 patients with hepatocellular carcinoma (etiology, presence of cirrhosis, stage of the tumor, treatment and disease outcome)...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27793774/oncogenic-potential-of-cyp24a1-in-lung-adenocarcinoma
#13
Hiroe Shiratsuchi, Zhuwen Wang, Guoan Chen, Paramita Ray, Jules Lin, Zhuo Zhang, Lili Zhao, David Beer, Dipankar Ray, Nithya Ramnath
INTRODUCTION: We have previously demonstrated that a subset of lung cancer cells express higher CYP24A1 mRNA, a metabolizing enzyme for 1,25-D3, compared to benign tumors or surrounding normal lung and that high CYP24A1 mRNA expression is associated with poor prognosis in resected lung adenocarcinoma (AC). We hypothesized that CYP24A1 has oncogenic potential and increased CYP24A1 expression may contribute to tumor growth, whereas, CYP24A1 targeting may reduce tumor burden. METHODS: Two low CYP24A1 expressing human lung cancer cell lines (SK-LU-1 and Calu-6) were stably transfected either with an empty lentiviral vector or with the CYP24A1 expressing vector...
October 26, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27789962/18f-fludrodeoxyglucose-maximal-standardized-uptake-value-and-metabolic-tumor-burden-are-associated-with-major-chemotherapy-related-tumor-markers-in-nsclc-patients
#14
Lu Bai, Chihua Guo, Jiansheng Wang, Xiang Liu, Yang Li, Miao Li, Youmin Guo, Xiaoyi Duan
OBJECTIVE: Metabolic activity and tumor burden are significant for prognosis and metastasis of non-small cell lung cancer (NSCLC), including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Chemotherapy resistance is a great challenge for treating NSCLC patients and is also closely related with several biomarkers such as epidermal growth factor receptor (EGFR), p53, and excision repair cross-complementing group 1 protein (ERCC1)...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27782997/topical-minocycline-effectively-decontaminates-and-reduces-inflammation-in-infected-porcine-wounds
#15
Lauren Tracy Daly, David M Tsai, Mansher Singh, Kristo Nuutila, Raquel A Minasian, Cameron C Y Lee, Elizabeth Kiwanuka, Florian Hackl, Andrew B Onderdonk, Johan P E Junker, Elof Eriksson, Edward J Caterson
BACKGROUND: Wound infection can impair postoperative healing. Topical antibiotics have potential to treat wound infection and inflammation and minimize the adverse effects associated with systemic antibiotics. METHODS: Full-thickness porcine wounds were infected with Staphylococcus aureus. Using polyurethane wound enclosure devices, wounds were treated with topical 100 μg/ml minocycline, topical 1000 μg/ml minocycline, topical saline control, or 4 mg/kg intravenous minocycline...
November 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27705910/indoleamine-2-3-dioxygenase-regulates-anti-tumor-immunity-in-lung-cancer-by-metabolic-reprogramming-of-immune-cells-in-the-tumor-microenvironment
#16
Cara C Schafer, Yong Wang, Kenneth P Hough, Anandi Sawant, Stefan C Grant, Victor J Thannickal, Jaroslaw Zmijewski, Selvarangan Ponnazhagan, Jessy S Deshane
Indoleamine 2,3-dioxygenase (IDO) has been implicated in immune evasion by tumors. Upregulation of this tryptophan (Trp)-catabolizing enzyme, in tumor cells and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment (TME), leads to Trp depletion that impairs cytotoxic T cell responses and survival; however, exact mechanisms remain incompletely understood. We previously reported that a combination therapy of gemcitabine and a superoxide dismutase mimetic promotes anti-tumor immunity in a mouse model of lung cancer by inhibiting MDSCs, enhancing polyfunctional response of CD8+ memory T cells, and extending survival...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27698001/assessment-of-total-lesion-glycolysis-by-18f-fdg-pet-ct-significantly-improves-prognostic-value-of-gep-and-iss-in-myeloma
#17
James E McDonald, Marcus M Kessler, Michael W Gardner, Amy F Buros, James A Ntambi, Sarah Waheed, Frits van Rhee, Maurizio Zangari, Christoph Heuck, Nathan Petty, Carolina Schinke, Sharmilan Thanendrarajan, Alan Mitchell, Antje Hoering, Bart Barlogie, Gareth Morgan, Faith E Davies
INTRODUCTION: Fluorine-18 fluorodexyglucose positron emission tomography with CT attenuation correction (18F-FDG PET/CT) is useful in the detection and enumeration of focal lesions and in semi-quantitative characterization of metabolic activity (glycolytic phenotype) by calculation of glucose uptake. Total lesion glycolysis (TLG) and metabolic tumor volume (MTV) have the potential to improve the value of this approach and enhance the prognostic value of disease burden measures. This study aims to determine whether TLG and MTV are associated with PFS and OS, and whether they improve risk assessments such as ISS stage and GEP70 risk...
October 3, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27688649/guanylyl-cyclase-c-signaling-axis-and-colon-cancer-prevention
#18
REVIEW
Amanda M Pattison, Dante J Merlino, Erik S Blomain, Scott A Waldman
Colorectal cancer (CRC) is a major cause of cancer-related mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C (GUCY2C), a transmembrane receptor expressed on intestinal epithelial cells, plays an important role in orchestrating intestinal homeostatic mechanisms...
September 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27674502/utility-of-metabolic-tumor-burden-calculated-from-dual-time-point-fdg-positron-emission-tomography-computed-tomography-to-evaluate-prognostic-value-of-oropharyngeal-or-hypopharyngeal-cancer
#19
H Kuwabara, A Toriihara, K Nakagawa, K Toda, U Tateishi, R I Yoshimura
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27638841/restoring-retinoic-acid-attenuates-intestinal-inflammation-and-tumorigenesis-in-apcmin-mice
#20
Hweixian Leong Penny, Tyler R Prestwood, Nupur Bhattacharya, Fionna Sun, Justin A Kenkel, Matthew G Davidson, Lei Shen, Luis A Zuniga, E Scott Seeley, Reetesh Pai, Okmi Choi, Lorna Tolentino, Jinshan Wang, Joseph L Napoli, Edgar G Engleman
Chronic intestinal inflammation accompanies familial adenomatous polyposis (FAP) and is a major risk factor for colorectal cancer in patients with this disease, but the cause of such inflammation is unknown. Because retinoic acid (RA) plays a critical role in maintaining immune homeostasis in the intestine, we hypothesized that altered RA metabolism contributes to inflammation and tumorigenesis in FAP. To assess this hypothesis, we analyzed RA metabolism in the intestines of patients with FAP as well as APC(Min/+) mice, a model that recapitulates FAP in most respects...
September 16, 2016: Cancer Immunology Research
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