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Waleed Ali Abou Samra, Eman Azmy Awad, Amr Hassan El Kannishy
AIM: To evaluate the visual and topographic outcomes of a two-stage approach treatment for selected cases of progressive keratoconus (KC); corneal collagen cross-linking (CXL) followed by phacoemulsification with toric intraocular lens (IOL) implantation. METHODS: The study included 9 eyes of 6 patients diagnosed with progressive KC, aged from 35 to 47 years (41.6±11.2 years). All studied eyes underwent a two-stage approach treatment: first corneal collagen CXL followed after at least 6 months by phacoemulsification with foldable toric IOL implantation in both eyes of three patients and only one eye of the other three patients...
October 3, 2016: Eye & Contact Lens
Silvia Torices, Antonio Julia, Pedro Muñoz, Ignacio Varela, Alejandro Balsa, Sara Marsal, Antonio Fernández-Nebro, Francisco Blanco, Marcos López-Hoyos, Víctor Martinez-Taboada, Jose L Fernández-Luna
BACKGROUND: Toll-like receptor (TLR) family members are key players in inflammation. TLR10 has been poorly studied in chronic inflammatory disorders, and its clinical relevance in rheumatoid arthritis (RA) is as yet unknown. We aimed at identifying TLR10 variants within all coding regions of the gene in patients with RA as well as studying their functional and clinical significance. METHODS: TLR10 gene variants were studied by performing sequencing of 66 patients with RA and 30 control subjects...
October 4, 2016: Arthritis Research & Therapy
Rick Potvin, Brent A Kramer, David R Hardten, John P Berdahl
PURPOSE: To analyze intraocular lens (IOL) orientation data from an online toric back-calculator ( for determining if differences were apparent by lens type. METHODS: A retrospective review of toric back-calculations that included IOL identification and intended orientation axis. RESULTS: Of 12,812 total validated calculation records, 8,229 included intended orientation and lens identification data. Of the latter, 5,674 calculations (69%) involved lenses oriented 5° or more from their intended position...
2016: Clinical Ophthalmology
Sahil Bhandari, Manas Nath
INTRODUCTION: Toric intraocular lenses (IOLs) are an effective way of compensating preexisting corneal astigmatism during cataract surgery. To achieve success, it is imperative to align the toric IOLs in desired position and preoperative reference marking is one among the three important steps for accurate alignment. To make the marking procedure simpler and effective, we have modified the conventional three-step slit lamp-based technique. MATERIALS AND METHODS: Patient is seated in front of the slit lamp and asked to keep the chin over chin rest...
August 2016: Indian Journal of Ophthalmology
Sherif A Eissa
PURPOSE: To assess the outcomes of sulcus implantation of the Visian(®) implantable collamer lens (ICL) to correct pseudophakic myopic anisometropic amblyopia with myopic shift and/or primary refractive overcorrection. METHODS: Prospective case series enrolled 14 pseudophakic eyes of 14 patients, 5-9 years old, with history of cataract surgery and primary in the bag-intraocular lenses (IOL) implantation, followed by myopic shift and/or refractive overcorrection and anisometropic amblyopia of variable degrees...
September 29, 2016: Acta Ophthalmologica
Min-Jun Gim, Dong Ki Yoon
We dynamically controlled the configuration of layering structures built by smectic A liquid crystal molecules using the combination method of the microchannel confinement and the in-plane electric field to realize the linearly polarized illuminator and bistable structures. Once a mild in-plane electric field (∼30 V) is applied between polymeric walls, the layer configuration was changed from the toric focal conic domains to periodic zigzag patterns of alternatively packed focal conic domains. The transformed zigzag patterns maintained their structures even after turning off the applied electric fields, revealing the ability for use in a bistable memory device...
October 4, 2016: ACS Applied Materials & Interfaces
Hu-Ping Song, Bing-Yu Tian, Jing Peng
AIM: To evaluate the efficacy of toric intraocular lens markers-assisted implantation of the scleral-fixated intraocular lens (SFIOL). METHODS: From October 2010 to December 2013, all patients who had undergone secondary SFIOL implantation were assigned to group 1 and 2, in group 1 SFIOL was performed with the assist of radial keratotomy (RK)-marker, and in group 2 SFIOL was performed with the assisted of toric intraocular lens markers (T-and axis markers). Patients' demographic data and information on baseline preoperative visual acuity, indication for surgery and latest postoperative visual acuity were collected and analyzed...
2016: International Journal of Ophthalmology
Bin Zhang, Jing-Xue Ma, Dan-Yan Liu, Cong-Rong Guo, Ying-Hua Du, Xiu-Jin Guo, Yue-Xian Cui
AIM: To evaluate the effects of posterior corneal surface measurements on the accuracy of total estimated corneal astigmatism. METHODS: Fifty-seven patients with toric intraocular lens (IOL) implantation and posterior corneal astigmatism exceeding 0.5 diopter were enrolled in this retrospective study. The keratometric astigmatism (KA) and total corneal astigmatism (TA) were measured using a Pentacam rotating Scheimpflug camera to assess the outcomes of AcrySof IOL implantation...
2016: International Journal of Ophthalmology
Andreas Frings, Johannes Steinberg, Vasyl Druchkiv, Stephan J Linke, Toam Katz
PURPOSE: This study was initiated to introduce the term non-corneal ocular residual astigmatism (N-CORA) as a new parameter in astigmatic change analysis after implantation of two different types of non-toric, multifocal intraocular lenses (MIOL). METHODS: Seventy-two eyes from 72 consecutive patients after MIOL surgery were studied in terms of a retrospective, cross-sectional data analysis. Two types of spherical MIOL were used. Surgical technique in all patients was a 2...
September 24, 2016: International Ophthalmology
Y P Zhong, D Xu, P Wang, C Song, Q J Guo, W X Liu, K Xu, B X Xia, C-Y Lu, Siyuan Han, Jian-Wei Pan, H Wang
Anyons are exotic quasiparticles obeying fractional statistics, whose behavior can be emulated in artificially designed spin systems. Here we present an experimental emulation of creating anyonic excitations in a superconducting circuit that consists of four qubits, achieved by dynamically generating the ground and excited states of the toric code model, i.e., four-qubit Greenberger-Horne-Zeilinger states. The anyonic braiding is implemented via single-qubit rotations: a phase shift of π related to braiding, the hallmark of Abelian 1/2 anyons, has been observed through a Ramsey-type interference measurement...
September 9, 2016: Physical Review Letters
M Brožková, M Filipec, L Filipová, A Holubová, Z Hlinomazová
AIM: The aim of our study was to evaluate the outcome of cataract surgeries with implantation of intraocular trifocal toric lens, and to study the accuracy of astigmatism correction, lens rotational stability, and safety of the procedures. PATIENTS AND METHODS: Our study comprised 22 eyes of 16 patients who underwent unilateral or bilateral implantation of AT LISA tri toric 939MP, or its implantation in combination with AT LISA tri 839MP. Mean patient age was 58 ± 11 years (39 to 75 years)...
2016: Ceská a Slovenská Oftalmologie
Deborah Jones, Craig Woods, Lyndon Jones, Nathan Efron, Philip Morgan
PURPOSE: To understand long-term contact lens prescribing habits of Canadian optometrists. METHODS: One thousand optometrists were surveyed annually from 2000 to 2015. Information was requested on the first ten patients examined after receiving the survey. RESULTS: Over the 16-year survey period, 1987 optometrists provided information on 19,143 patients. Mean age of the patients was 32.7±14.4years. Ratio of females to males was 2:1, the ratio of new fits to refits was 2:3...
September 16, 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
A Talamillo, L Grande, P Ruiz-Ontañon, C Velasquez, P Mollinedo, S Torices, P Sanchez-Gomez, A Aznar, A Esparis-Ogando, C Lopez-Lopez, C Lafita, M T Berciano, J A Montero, A Vazquez-Barquero, V Segura, N T Villagra, A Pandiella, M Lafarga, J Leon, J A Martinez-Climent, V Sanz-Moreno, J L Fernandez-Luna
Long-term survival remains low for most patients with glioblastoma (GBM), which reveals the need for markers of disease outcome and novel therapeutic targets. We describe that ODZ1 (also known as TENM1), a type II transmembrane protein involved in fetal brain development, plays a crucial role in the invasion of GBM cells. Differentiation of glioblastoma stem-like cells drives the nuclear translocation of an intracellular fragment of ODZ1 through proteolytic cleavage by signal peptide peptidase-like 2a. The intracellular fragment of ODZ1 promotes cytoskeletal remodelling of GBM cells and invasion of the surrounding environment both in vitro and in vivo...
September 19, 2016: Oncogene
Toam Katz, Johannes Steinberg, Vasyl Druchkiv, Stephan J Linke, Andreas Frings
The purpose of this study was to analyze ocular residual astigmatism (ORA) before and after implantation of two different optical types of non-toric multifocal intraocular lenses (MIOL) in pre-cataract patients. This retrospective cohort study analyzed 72 eyes from 72 consecutive patients after MIOL surgery . To investigate magnitude and axis of astigmatic changes, the concepts of true corneal astigmatism and Alpins vector method were applied. There were no statistically significant between-group differences prior to surgery...
September 13, 2016: International Ophthalmology
Qinghe Jing, Yating Tang, Dongjin Qian, Yi Lu, Yongxiang Jiang
PURPOSE: To evaluate the characteristics of the posterior corneal surface in patients with high myopia before cataract surgery. METHODS: We performed a cross-sectional study at the Eye and ENT Hospital of Fudan University, Shanghai, China. Corneal astigmatism and axial length were measured with a rotating Scheimpflug camera (Pentacam) and partial coherence interferometry (IOLMaster) in a high-myopia study group of 167 eyes (axial length ≥ 26 mm) and a control group of 150 eyes (axial length > 20 mm and < 25 mm)...
2016: PloS One
Xiao Zhang, Xiang-Chen Tao, Zhi-Wei Li, Wei-Yan Zhou, Ping Ma, Chun-Xiao Zhang, Yu-Meng Wang, Guo-Ying Mu
The present study reports the use of a phakic toric Implantable Collamer Lens (ICL) that improved the refraction correction of high myopia and astigmatism in a case of keratectasia following corneal cross-linking. A 31-year-old male was diagnosed with keratectasia 12 years after laser-assisted in situ keratomileusis (LASIK). Following LASIK, the manifest refraction was -3.50-2.25×90 [0.1 logarithmic expression (LogMAR) best corrected visual acuity (BVCA)] in the right eye and -8.00-3.50×175 (0.3 LogMAR BCVA) in the left eye, with a LogMAR uncorrected distance visual acuity (UDVA) of 0...
September 2016: Experimental and Therapeutic Medicine
Jeihoon Lee, Hun Lee, David Sung Yong Kang, Jin Young Choi, Eung Kweon Kim, Tae Im Kim
PURPOSE: To compare the effectiveness of toric foldable iris-fixated phakic intraocular lens (pIOL) implantation and non-toric foldable iris-fixated pIOL implantation with limbal relaxing incisions (LRIs) for correcting moderate-to-high astigmatism in myopic eyes. MATERIALS AND METHODS: The medical records of 146 patients (195 eyes) with myopic astigmatism who underwent toric foldable iris-fixated pIOL implantation (toric group; 94 eyes) or non-toric foldable iris-fixated pIOL implantation with concurrent LRIs (LRI group; 101 eyes) were retrospectively reviewed...
November 2016: Yonsei Medical Journal
Jagat Ram, Rishiraj Singh, Rohit Gupta, Garvit Bhutani, Parul Chawla Gupta, Jaspreet Sukhija
PURPOSE: To evaluate the effect of toric intraocular lens (IOL) implantation on the refractive outcomes in children with cataract and preexisting corneal astigmatism. METHODS: We included children between the age group of 8-14 years who were randomized into group I (toric) and group II (non-toric), in which toric and spherical IOLs were implanted, respectively, after phacoaspiration. Primary outcome measure was comparison of preoperative keratometric and postoperative refractive cylinder...
August 30, 2016: Acta Ophthalmologica
Pawan Prasher, Jasdeep Singh Sandhu
The purpose of the study was to assess the prevalence of corneal astigmatism before cataract surgery in Indian population. The setting of this study was at the Sant Sarwan Dass Charitable Eye Hospital, Jalandhar, India. This is a clinic-based retrospective study. Charts of patients who underwent cataract surgery over a two-year period were retrospectively reviewed, and preoperative keratometric measurements were collected and analyzed. The mean age of 2316 patients (2502 eyes) was 59.54 ± 10.96 years. The corneal astigmatism was less than 1...
August 27, 2016: International Ophthalmology
John S M Chang, Vincent K C Chan, Jack C M Ng, Antony K P Law
Background. The vision with diffractive toric multifocal intraocular lenses after cataract surgery in long eyes has not been studied previously. Objectives. To report visual performance after bilateral implantation of a diffractive toric multifocal intraocular lens in high myopes. Methods. Prospective, observational case series to include patients with axial length of ≥26 mm and corneal astigmatism of >1 dioptre who underwent bilateral AT LISA 909M implantation. Postoperative examinations included photopic and mesopic distance, intermediate, and near visual acuity; photopic contrast sensitivity; visual symptoms (0-5); satisfaction (1-5); and spectacle independence rate...
2016: Journal of Ophthalmology
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