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electrical injury

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https://www.readbyqxmd.com/read/27914232/resuscitation-attempts-and-duration-in-traumatic-out-of-hospital-cardiac-arrest
#1
Ben Beck, Janet E Bray, Peter Cameron, Lahn Straney, Emily Andrew, Stephen Bernard, Karen Smith
BACKGROUND: This study aimed to understand factors associated with paramedics' decision to attempt resuscitation in traumatic out-of-hospital cardiac arrest (OHCA) and to characterise resuscitation attempts ≤10min in patients who die at the scene. METHODS: The Victorian Ambulance Cardiac Arrest Registry (VACAR) was used to identify all cases of traumatic OHCA between July 2008 and June 2014. We excluded cases <16 years of age or with a mechanism of hanging or drowning...
November 30, 2016: Resuscitation
https://www.readbyqxmd.com/read/27910042/direct-cardiac-reprogramming-as-a-novel-therapeutic-strategy-for-treatment-of-myocardial-infarction
#2
Hong Ma, Li Wang, Jiandong Liu, Li Qian
Direct reprogramming of fibroblasts into induced cardiomyocytes (iCMs) holds great promise as a novel therapy for the treatment of heart failure, a common and morbid disease that is usually caused by irreversible loss of functional cardiomyocytes (CMs). Recently, we and others showed that in a murine model of acute myocardial infarction, delivery of three transcription factors, Gata4, Mef2c, and Tbx5 converted endogenous cardiac fibroblasts into functional iCMs. These iCMs integrated electrically and mechanically with surrounding myocardium, resulting in a reduction in scar size and an improvement in heart function...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27904757/brain-hemorrhage-after-electrical-burn-injury-case-report-and-probable-mechanism
#3
Gutierrez Aceves Guillermo Axayacalt, Ceja Espinosa Alejandro, Rios Alanis Marcos, Ruiz Flores Milton Inocencio, Herrera Gonzalez Jose Alfredo
BACKGROUND: High-voltage electric injury may induce lesion in different organs. In addition to the local tissue damage, electrical injuries may lead to neurological deficits, musculoskeletal damage, and cardiovascular injury. Severe vascular damage may occur making the blood vessels involved prone to thrombosis and spontaneous rupture. CASE DESCRIPTION: Here, we present the case of a 39-year-old male who suffered an electrical burn with high tension wire causing intracranial bleeding...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27904500/electrical-stimulation-promotes-regeneration-of-injured-oculomotor-nerves-in-dogs
#4
Lei Du, Min Yang, Liang Wan, Xu-Hui Wang, Shi-Ting Li
Functional recovery after oculomotor nerve injury is very poor. Electrical stimulation has been shown to promote regeneration of injured nerves. We hypothesized that electrical stimulation would improve the functional recovery of injured oculomotor nerves. Oculomotor nerve injury models were created by crushing the right oculomotor nerves of adult dogs. Stimulating electrodes were positioned in both proximal and distal locations of the lesion, and non-continuous rectangular, biphasic current pulses (0.7 V, 5 Hz) were administered 1 hour daily for 2 consecutive weeks...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27896147/early-debridement-and-delayed-primary-vascularized-cover-in-forearm-electrical-burns-a-prospective-study
#5
Aniruddh Mene, Gautam Biswas, Atul Parashar, Anish Bhattacharya
AIM: To look into the management options of early debridement of the wound, followed by vascularized cover to bring in fresh blood supply to remaining tissue in electrical burns. METHODS: A total of 16 consecutive patients sustaining full thickness forearm burns over a period of one year were included in the study group. Debridement was undertaken within 48 h in 13 patients. Three patients were taken for debridement after 48 h. Debridement was repeated within 2-4 d after daily wound assessment and need for further debridement...
November 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27894559/helicopter-transport-in-regionalized-burn-care-one-program-s-perspective
#6
Benjamin Nicholson, Harinder Dhindsa
BACKGROUND: The decision to use helicopter EMS (HEMS) for the transport of burn patients is a complex decision. This analysis sought to evaluate burn patients flown to burn centers who met predetermined criteria for patients who likely benefit from HEMS care. METHODS: A retrospective transport chart review of all burn transports covering the preceding nine and a half years was conducted to evaluate for HEMS appropriate criteria defined as patients requiring advanced airway management, ventilator support, facial burns, inhalation injury, circumferential burns, electrical or chemical burn, or major burns...
November 2016: Air Medical Journal
https://www.readbyqxmd.com/read/27893476/comparison-of-muscle-involvement-and-posture-between-the-conventional-deadlift-and-a-walk-in-style-deadlift-machine
#7
Benjamin J Snyder, Courtney P Cauthen, Scott R Senger
The deadlift exercise is one of the most effective exercises for developing lower-body strength; however, technique errors can lead to low back injuries. The use of a 'walk-in' deadlift machine removes the weight bar by using a lever system with independent handles on either side of the body. Theoretically, this would allow alignment of the load with the center of gravity, encouraging a more upright torso and decreasing the involvement of the low back extensors. This study compared trunk angle, knee angle and electrical activity of key muscles between the conventional deadlift (CDL) and two foot positions (ball of foot or toe alignment) with pronated grip, (called BallPro and ToePro) of a walk-in deadlift machine among high-skilled and low-skilled lifters...
November 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27891636/effects-of-pulsed-radiofrequency-neuromodulation-on-the-rat-with-overactive-bladder
#8
En Jen, Tsung-Hsun Hsieh, Tsung-Che Lu, Meng-Chao Chen, Fu-Jung Lee, Chih-Ting Lin, Shih-Ching Chen, Pei-Yi Chu, Chih-Wei Peng, Chii-Wann Lin
AIM: To quantify the effects of pulsed radiofrequency (PRF) electrical stimulations of the pudendal and pelvic nerves on the bladder function of rats with detrusor overactivity. METHODS: All rats were pretreated with a continuous transvesical infusion of 0.5% acetic acid (AA) for inducing detrusor overactivity. Intravesical pressure was recorded using cysometrography (CMG) during the continuous transvesical infusion to examine the effects of PRF electrical stimulation of the pudendal and pelvic nerves individually...
November 28, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27891095/differential-rna-expression-profile-of-skeletal-muscle-induced-by-experimental-autoimmune-myasthenia-gravis-in-rats
#9
Henry J Kaminski, Keiichi Himuro, Jumana Alshaikh, Bendi Gong, Georgiana Cheng, Linda L Kusner
The differential susceptibility of skeletal muscle by myasthenia gravis (MG) is not well understood. We utilized RNA expression profiling of extraocular muscle (EOM), diaphragm (DIA), and extensor digitorum (EDL) of rats with experimental autoimmune MG (EAMG) to evaluate the hypothesis that muscles respond differentially to injury produced by EAMG. EAMG was induced in female Lewis rats by immunization with acetylcholine receptor purified from the electric organ of the Torpedo. Six weeks later after rats had developed weakness and serum antibodies directed against the AChR, animals underwent euthanasia and RNA profiling performed on DIA, EDL, and EOM...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27886883/restorative-treatments-for-spinal-cord-injury
#10
REVIEW
Stephanie Chen, Allan D Levi
Spinal cord injury remains an incurable disease with an enormous impact functionally, financially, and emotionally on affected individuals and their families. Current treatment modalities are focused on minimizing secondary injury and maximizing residual function via rehabilitation. In this article, the authors discuss ambitious advancements under investigation aimed at restoring function. These promising experimental treatments focus on neuroprotection with hypothermia and pharmacologic therapies, regeneration via cell transplantation, and rewiring with electrical stimulation...
January 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/27884958/activity-dependent-redistribution-of-kv2-1-ion-channels-on-rat-spinal-motoneurons
#11
Shannon H Romer, Adam S Deardorff, Robert E W Fyffe
Homeostatic plasticity occurs through diverse cellular and synaptic mechanisms, and extensive investigations over the preceding decade have established Kv2.1 ion channels as key homeostatic regulatory elements in several central neuronal systems. As in these cellular systems, Kv2.1 channels in spinal motoneurons (MNs) localize within large somatic membrane clusters. However, their role in regulating motoneuron activity is not fully established in vivo. We have previously demonstrated marked Kv2.1 channel redistribution in MNs following in vitro glutamate application and in vivo peripheral nerve injury (Romer et al...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27883352/-long-term-prognosis-in-patients-with-vasovagal-syncope-after-pacemaker-implantation
#12
REVIEW
Daria Bałczewska, Krzysztof Kaczmarek, Paweł Ptaszyński, Jerzy K Wranicz, Iwona Cygankiewicz
Patients with syncope, without presence of a structural or primary electrical disease, have a very good prognosis. On the other hand, recurring syncope has a negative impact on quality of life and involves a real risk of physical injuries. Vasovagal syncope usually requires no medical therapy and the most commonly recommended instruction include avoidance of fainting triggers, exercise that mainly provoke leg muscles tension, increase salt consumption and drink indicated amount of fluids. In the case cardioinhibitory type of vasovagal syncope the pacemaker implantation can consider...
November 25, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27882326/ventricular-fibrillation-induced-cardiac-arrest-results-in-regional-cardiac-injury-preferentially-in-left-anterior-descending-coronary-artery-territory-in-piglet-model
#13
Giridhar Kaliki Venkata, John R Forder, Dan Clark, Andre Shih, Sharda Udassi, Srinivasarao Badugu, Melissa A Lamb, Stacy L Porvasnik, Renata S Shih, Dalia Colon-Lopez, Arno L Zaritsky, Ikram U Haque, Jai P Udassi
Objective. Decreased cardiac function after resuscitation from cardiac arrest (CA) results from global ischemia of the myocardium. In the evolution of postarrest myocardial dysfunction, preferential involvement of any coronary arterial territory is not known. We hypothesized that there is no preferential involvement of any coronary artery during electrical induced ventricular fibrillation (VF) in piglet model. Design. Prospective, randomized controlled study. Methods. 12 piglets were randomized to baseline and electrical induced VF...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27881405/effectiveness-of-individualised-lung-recruitment-strategies-at-birth-an-experimental-study-in-preterm-lambs
#14
David G Tingay, Anushi E Rajapaksa, Emanuela Zannin, Prue M Pereira-Fantini, Raffaele Dellacà, Elizabeth Perkins, Cornelis Elroy E Zonneveld, Andy Adler, Don Black, Inez Frerichs, Anna Lavizzari, Magdy Sourial, Bartłomiej Grychtol, Fabio Mosca, Peter G Davis
Respiratory transition at birth involves rapidly clearing fetal lung liquid and preventing efflux back into the lung whilst aeration is established. We have developed a sustained inflation (SIOPT) individualized to volume-response and a dynamic tidal positive end-expiratory pressure (open lung volume, OLV) strategy that both enhance this process. We aimed to compare the effect of each with a group managed with PEEP of 8 cmH2O and no recruitment manoeuvre (No-RM), on gas exchange, lung mechanics, spatiotemporal aeration and lung injury in 127±1d preterm lambs...
November 23, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27879672/electric-signals-regulate-the-directional-migration-of-oligodendrocyte-progenitor-cells-opcs-via-%C3%AE-1-integrin
#15
Bangfu Zhu, Matthew Nicholls, Yu Gu, Gaofeng Zhang, Chao Zhao, Robin J M Franklin, Bing Song
The guided migration of neural cells is essential for repair in the central nervous system (CNS). Oligodendrocyte progenitor cells (OPCs) will normally migrate towards an injury site to re-sheath demyelinated axons; however the mechanisms underlying this process are not well understood. Endogenous electric fields (EFs) are known to influence cell migration in vivo, and have been utilised in this study to direct the migration of OPCs isolated from neonatal Sprague-Dawley rats. The OPCs were exposed to physiological levels of electrical stimulation, and displayed a marked electrotactic response that was dependent on β1 integrin, one of the key subunits of integrin receptors...
November 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27875900/effects-of-necrostatin-1-an-inhibitor-of-necroptosis-and-its-inactive-analogue-nec-1i-on-basal-cardiovascular-function
#16
A Szobi, T Rajtik, A Adameova
Inhibition of receptor-interacting serine/threonine-protein kinase 1 (RIP1) by necrostatin-1 (Nec-1) alleviates cardiac injury due to prevention of necroptotic cell death. Its inactive analogue necrostatin-1i (Nec-1i), lacking RIP1 activity, serves as a suitable control. It is unknown if these agents influence the heart function in the absence of damaging stimuli. For this purpose, we measured intraarterial blood pressure (systolic - sBP and diastolic - dBP) and ECG parameters after a bolus administration of Nec-1 and Nec-1i in rats during 30 min...
November 23, 2016: Physiological Research
https://www.readbyqxmd.com/read/27871577/lack-of-electrical-interference-between-spinal-cord-stimulators-and-other-implanted-electrical-pulse-devices
#17
Alaa Abd-Elsayed, Ravi Grandhi, Harsh Sachdeva
Spinal cord stimulators (SCSs) have been used for decades to treat chronic pain. SCSs are often used to treat patients with chronic back pain caused by failed back surgery syndrome, patients with complex regional pain syndrome, or individuals who are not candidates for surgery. SCSs are a relative contraindication in patients with another electrical pulse device. We present 3 patients who received SCS despite having another implant in place. There was no interaction between devices. The first case was a patient with failed back surgery syndrome who had an implantable cardiac defibrillator and an SCS implant...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27864716/single-incision-laparoscopic-surgery-increases-the-risk-of-unintentional-thermal-injury-from-the-monopolar-bovie-instrument-in-comparison-with-traditional-laparoscopy
#18
Nicole T Townsend, Edward L Jones, Doug Overbey, Bruce Dunne, Jennifer McHenry, Thomas N Robinson
BACKGROUND: Single-incision laparoscopic surgery (SILS) places multiple instruments in close, parallel proximity, an orientation that may have implications in the production of stray current from the monopolar "Bovie" instrument. The purpose of this study was to compare the energy transferred during SILS compared to traditional four-port laparoscopic surgery (TRD). METHOD: In a laparoscopic simulator, instruments were inserted via SILS or TRD setup. The monopolar generator delivered energy to a laparoscopic L-hook instrument for 5-s activations on 30-Watts coag mode...
November 18, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27857728/harnessing-neural-activity-to-promote-repair-of-the-damaged-corticospinal-system-after-spinal-cord-injury
#19
REVIEW
John H Martin
As most spinal cord injuries (SCIs) are incomplete, an important target for promoting neural repair and recovery of lost motor function is to promote the connections of spared descending spinal pathways with spinal motor circuits. Among the pathways, the corticospinal tract (CST) is most associated with skilled voluntary functions in humans and many animals. CST loss, whether at its origin in the motor cortex or in the white matter tracts subcortically and in the spinal cord, leads to movement impairments and paralysis...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27857643/clinical-and-demographic-features-of-burn-injuries-in-karachi-a-six-year-experience-at-the-burns-centre-civil-hospital-karachi
#20
S A Ali, S Hamiz-Ul-Fawwad, E Al-Ibran, G Ahmed, A Saleem, D Mustafa, M Hussain
Burn injuries are a leading cause of morbidity and mortality, with 195,000 deaths annually. This study was conducted to identify the demographics of burn victims and the effect of different variables on the outcome of their injuries. 4016 patients admitted to the Burns Centre, Civil Hospital Karachi from January 2006 to December 2011 were retrospectively analyzed. Demographics, burn injury details and their outcome were recorded in a pre-designed questionnaire. Injuries were categorized as: fire, chemical, scald or electrical...
March 31, 2016: Annals of Burns and Fire Disasters
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