keyword
MENU ▼
Read by QxMD icon Read
search

Cytokine signal transduction

keyword
https://www.readbyqxmd.com/read/28096534/novel-therapeutic-approach-to-improve-hematopoiesis-in-low-risk-mds-by-targeting-mdscs-with-the-fc-engineered-cd33-antibody-bi-836858
#1
E A Eksioglu, X Chen, K-H Heider, B Rueter, K L McGraw, A A Basiorka, M Wei, A Burnette, P Cheng, J Lancet, R Komrokji, J Djeu, A List, S Wei
We recently reported that the accumulation of myeloid-derived suppressor cells (MDSC), defined as CD33(+)HLA-DR(-)Lin(-), plays a direct role in the pathogenesis of myelodysplastic syndrome (MDS). In particular, CD33 is strongly expressed in MDSC isolated from patients with MDS where it plays an important role in MDSC-mediated hematopoietic suppressive function through its activation by S100A9. Therefore, we tested whether blocking this interaction with a fully human, Fc-engineered monoclonal antibody against CD33 (BI 836858) suppresses CD33-mediated signal transduction and improves the bone marrow microenvironment in MDS...
January 18, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28086922/transcriptional-profiles-in-bursal-b-lymphoid-dt40-cells-infected-with-very-virulent-infectious-bursal-disease-virus
#2
Rong Quan, Shanshan Zhu, Li Wei, Jing Wang, Xu Yan, Zixuan Li, Jue Liu
BACKGROUND: Infectious bursal disease virus (IBDV) causes a highly contagious, immunosuppressive disease in chickens. The virus mainly infects immature B lymphocytes in the bursa of Fabricius (BF). Chicken B cell line DT40, an avian leukosis virus-induced B cell line, supports very virulent IBDV (vvIBDV) infection in vitro and thereby serves as a good model for investigating the infection and pathogenesis of this virus. However, a transcriptome-wide understanding of the interaction between vvIBDV and B cells has not yet been achieved...
January 13, 2017: Virology Journal
https://www.readbyqxmd.com/read/28079886/hiv-1-nef-is-released-in-extracellular-vesicles-derived-from-astrocytes-evidence-for-nef-mediated-neurotoxicity
#3
A Sami Saribas, Stephanie Cicalese, Taha Mohseni Ahooyi, Kamel Khalili, Shohreh Amini, Ilker Kudret Sariyer
Human immunodeficiency virus-associated neurological disorders (HANDs) affect the majority of AIDS patients and are a significant problem among HIV-1-infected individuals who live longer because of combined anti-retroviral therapies. HIV-1 utilizes a number of viral proteins and subsequent cytokine inductions to unleash its toxicity on neurons. Among HIV-1 viral proteins, Nef is a small protein expressed abundantly in astrocytes of HIV-1-infected brains and has been suggested to have a role in the pathogenesis of HAND...
January 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28077574/platelet-activating-factor-mediates-endotoxin-tolerance-by-regulating-indoleamine-2-3-dioxygenase-dependent-expression-of-the-suppressor-of-cytokine-signaling-3
#4
Kyung Tae Noh, In Duk Jung, Gil Sun Cha, Myung-Kwan Han, Yeong-Min Park
Indoleamine 2, 3-dioxygenase (IDO) mediates immune tolerance, and suppressor of cytokine signaling 3 (SOCS3) negatively regulates the JAK/STAT signal transduction pathway. We previously determined plateletactivating factor (PAF) protects mice against lipopolysaccharide (LPS)-induced endotoxic shock, but its detailed mechanism of action was unknown. We performed survival experiments in IDO+/+ and IDO-/- mice using an LPSinduced endotoxemia model and rated organ injury (neutrophil infiltration, and liver function)...
January 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28074914/hydroxysafflor-yellow-a-attenuates-the-expression-of-inflammatory-cytokines-in-acute-soft-tissue-injury
#5
Fang Dong, Changjiang Xue, Yu Wang, Yuanyuan Peng, Yadan Zhang, Ming Jin, Baoxia Zang
We examined the effect of hydroxysafflor yellow A (HSYA) on the inflammatory response to strike-induced acute soft tissue injury in rats. Soft tissue injury was induced in rat leg muscles using a strike hammer, followed by intraperitoneal administration of HSYA at 16, 32, or 64 mg/kg. After 24 h, the rats were anaesthetized, blood and muscle samples were taken. Plasma levels of interleukin (IL)-6, IL-1β, and tumour necrosis factor (TNF)-αwere measured by enzyme-linked immunosorbent assay. Total RNA and protein were isolated from muscle tissue to determine the mRNA levels of IL-6, IL-1β, TNF-α, vascular cell adhesion molecule (VCAM)-1, and intercellular adhesion molecule (ICAM)-1, and the protein level of phosphorylated p38 mitogen-activated protein kinase (MAPK)...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28057547/intracellular-signaling-modifications-involved-in-the-anti-inflammatory-effect-of-4-alkoxy-6-9-dichloro-1-2-4-triazolo-4-3-a-quinoxalines-on-macrophages
#6
Antonio J Ruiz-Alcaraz, María Tristán-Manzano, Antonio Guirado, Jesús Gálvez, María Martínez-Esparza, Pilar García-Peñarrubia
Inflammation is part of a complex biological response directed by the immune system to fight pathogens and maintain homeostasis. Dysregulation of the inflammatory process leads to development of chronic inflammatory or autoimmune diseases. Several cell types, such as macrophages, and cytokines such as interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) are involved in the regulation of inflammation. The important role played by these cytokines as mediators of the inflammatory process and the side effects of current therapies have promoted the search of new therapeutic alternatives...
January 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28052368/synthesis-and-activity-of-the-salicylic-acid-ester-of-bakuchiol-in-psoriasis-surrogate-keratinocytes-and-skin-substitutes
#7
S Ma, K Gobis, W R Swindell, R Chaudhuri, R Bojanowski, K Bojanowski
BACKGROUND: Topical retinoids are effective in retarding skin ageing and restoring homeostasis in skin conditions such as psoriasis. However their adverse effects (AEs), which include irritation (retinoid dermatitis), photosensitivity and teratogenicity, limit their use and patient compliance. Development of retinoid analogues with minimal AEs would allow a broader and more compliant use. AIM: To synthesise a novel molecule, bakuchiol salicylate (bakusylan), with a modulatory gene expression profile similar to retinoids, using as reference three prescription retinoids: tretinoin, tazarotene and adapalene...
January 4, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28049142/danger-associated-molecular-patterns-in-alzheimer-s-disease
#8
REVIEW
Carmen Venegas, Michael T Heneka
Pathogen-associated molecular patterns (PAMPs) and endogenous "danger" signals, known as danger-associated molecular patterns (DAMPs), released from cells alert the innate immune system and activate several signal transduction pathways through interactions with the highly conserved pattern recognition receptors (PRRs). Both PAMPs and DAMPs directly induce proinflammatory cascades and trigger the formation of the inflammasome, mediating the release of cytokines. Here, we highlight the role of DAMPs, including amyloid β (Aβ), high-mobility group box 1 (HMGB1), the S100 family proteins, chromogranin A, and nucleic acids, in the innate-immune activation during the course of Alzheimer disease (AD), the most frequent neurodegenerative disorder...
January 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28035384/correlative-analyses-of-the-expression-levels-of-pias3-p-shp2-socs1-and-socs3-with-stat3-activation-in-human-astrocytomas
#9
Li-Hong Liu, Hong Li, Xiao-Xin Cheng, Qing-You Kong, Xiao-Yan Chen, Mo-Li Wu, Yan Li, Jia Liu, Cong Li
The importance of signal transducer and activator of transcription 3 (STAT3) signaling in the growth and survival of glioblastoma cells has been well documented, while the reasons leading to STAT3 activation remains to be elucidated. Suppressors of cytokine signaling (SOCS) 1 and SOCS3, SH2 domain‑containing phosphatase (SHP2) and protein inhibitors of activated STAT3 (PIAS3) are known to inhibit STAT3 signal transduction, while their expression statuses in the four grades of astrocytomas and relevance with STAT3 activation remain to be described...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28027695/inhibitory-mechanism-of-the-outer-membrane-growth-of-chronic-subdural-hematomas
#10
Koji Osuka, Yasuo Watanabe, Nobuteru Usuda, Masahiro Aoyama, Kenichiro Iwami, Mikinobu Takeuchi, Takeya Watabe, Masakazu Takayasu
We previously demonstrated that the inflammatory cytokine interleukin-6 (IL-6) activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway in fibroblasts within the outer membranes of chronic subdural hematomas (CSDHs), and the activation of this pathway may induce CSDH outer membrane growth. The inhibitory system for this signal transduction pathway is unknown. CSDH fluids were obtained from ten patients during trepanation surgery as the case group, and CSF samples were obtained from seven patients suffering from subarachnoid hemorrhage (SAH) on day 1 as the control group...
December 27, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28017802/signal-transduction-analysis-of-the-nlrp3-inflammasome-pathway-after-cellular-damage-and-its-paracrine-regulation
#11
Denise Veltman, Thessa Laeremans, Egle Passante, Heinrich J Huber
Activation of the NLRP3-inflammasome pathway and production of the inflammatory cytokine IL-1B after cellular damage caused by infarct or infection is a key process in several diseases such as acute myocardial infarction and inflammatory bowel disease. However, while the molecular triggers of the NLRP3-pathway after cellular damage are well known, the mechanisms that sustain or confine its activity are currently under investigation. We present here an Ordinary Differential Equation-based model that investigates the mechanisms of inflammasome activation and regulation in monocytes to predict IL-1β activation kinetics upon a two-step activation by Damage-Associate-Molecular-Particles (DAMP) and extracellular ATP...
December 22, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28017736/comparative-and-temporal-transcriptome-analysis-of-peste-des-petits-ruminants-virus-infected-goat-peripheral-blood-mononuclear-cells
#12
Siddappa Manjunath, Bishnu Prasad Mishra, Bina Mishra, Aditya Prasad Sahoo, Ashok K Tiwari, Kaushal Kishore Rajak, D Muthuchelvan, Shikha Saxena, Lakshman Santra, Amit Ranjan Sahu, Sajad Ahmad Wani, R P Singh, Y P Singh, Aruna Pandey, Sonam Kanchan, R K Singh, Gandham Ravi Kumar, Sarath Chandra Janga
Peste des petits ruminanats virus (PPRV), a morbillivirus causes an acute, highly contagious disease - peste des petits ruminants (PPR), affecting goats and sheep. Sungri/96 vaccine strain is widely used for mass vaccination programs in India against PPR and is considered the most potent vaccine providing long-term immunity. However, occurrence of outbreaks due to emerging PPR viruses may be a challenge. In this study, the temporal dynamics of immune response in goat peripheral blood mononuclear cells (PBMCs) infected with Sungri/96 vaccine virus was investigated by transcriptome analysis...
February 2, 2017: Virus Research
https://www.readbyqxmd.com/read/28012283/effect-of-exercise-training-on-signaling-of-interleukin-6-in-skeletal-muscles-of-type-2-diabetic-rats
#13
Pattarawan Pattamaprapanont, Chatchai Muanprasat, Sunhapas Soodvilai, Chutima Srimaroeng, Varanuj Chatsudthipong
OBJECTIVES: Diabetes and exercise training have been shown to involve interleukin 6 (IL-6) signaling in muscle. However, the relationship between the actions of these two stimuli on muscle IL-6 and their downstream components is still unknown. Thus, the effect of endurance training on the key components of muscle IL-6 signaling transduction was investigated in a rat model of type 2 diabetes. METHODS: Diabetes was induced by streptozotocin (STZ) in male Wistar rats fed a high-fat diet, with normal rats acting as controls...
July 2016: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/28008925/biallelic-jak1-mutations-in-immunodeficient-patient-with-mycobacterial-infection
#14
Davide Eletto, Siobhan O Burns, Ivan Angulo, Vincent Plagnol, Kimberly C Gilmour, Frances Henriquez, James Curtis, Miguel Gaspar, Karolin Nowak, Vanessa Daza-Cajigal, Dinakantha Kumararatne, Rainer Doffinger, Adrian J Thrasher, Sergey Nejentsev
Mutations in genes encoding components of the immune system cause primary immunodeficiencies. Here, we study a patient with recurrent atypical mycobacterial infection and early-onset metastatic bladder carcinoma. Exome sequencing identified two homozygous missense germline mutations, P733L and P832S, in the JAK1 protein that mediates signalling from multiple cytokine receptors. Cells from this patient exhibit reduced JAK1 and STAT phosphorylation following cytokine stimulations, reduced induction of expression of interferon-regulated genes and dysregulated cytokine production; which are indicative of signalling defects in multiple immune response pathways including Interferon-γ production...
December 23, 2016: Nature Communications
https://www.readbyqxmd.com/read/28005686/transcriptome-analyses-identify-key-cellular-factors-associated-with-hiv-1-associated-neuropathogenesis-in-infected-men
#15
Narasimhan J Venkatachari, Siddhartha Jain, Leah Walker, Shalmali Bivalkar-Mehla, Ansuman Chattopadhyay, Ziv Bar-Joseph, Charles Rinaldo, Ann Ragin, Eric Seaberg, Andrew Levine, James Becker, Eileen Martin, Ned Sacktor, Velpandi Ayyavoo
OBJECTIVE: HIV-1 viral proteins and host inflammatory factors have a direct role in neuronal toxicity in in vitro, however, the contribution of these factors in vivo in HIV-1 associated neurocognitive disorder (HAND) is not fully understood. We applied novel Systems Biology approaches to identify specific cellular and viral factors and their related pathways that are associated with different stages of HAND. DESIGN: A cross-sectional study of individuals enrolled in the Multicenter AIDS Cohort Study (MACS) including HIV-1 seronegative (N = 36) and HIV-1 seropositive individuals without neurocognitive symptoms (N = 16), or with mild neurocognitive disorder (MND) (N = 8) or HIV-associated dementia (HAD) (N = 16)...
December 21, 2016: AIDS
https://www.readbyqxmd.com/read/28004279/in-vitro-cultured-fetal-fibroblasts-have-myofibroblast-associated-characteristics-and-produce-a-fibrotic-like-environment-upon-stimulation-with-tgf-%C3%AE-1-is-there-a-thin-line-between-fetal-scarless-healing-and-fibrosis
#16
M Walraven, J J Akershoek, R H J Beelen, M M W Ulrich
Transforming growth factor-β (TGF-β) is a cytokine occurring in three isoforms with an important function in development and wound healing. In wound healing, prolonged TGF-β signaling results in myofibroblast differentiation and fibrosis. In contrast, the developing second-trimester fetal skin contains high levels of all three TGF-β isoforms but still has the intrinsic capacity to heal without scarring. Insight into TGF-β signal transduction during fetal wound healing might lead to methods to control the signaling pathway during adult wound healing...
December 21, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27988893/n-acetylglutaminoyl-s-farnesyl-l-cysteine-sig-1191-an-anti-inflammatory-molecule-that-increases-the-expression-of-the-aquaglyceroporin-aquaporin-3-in-human-keratinocytes
#17
José R Fernández, Corey Webb, Karl Rouzard, Michael Voronkov, Kristen L Huber, Jeffry B Stock, Maxwell Stock, Joel S Gordon, Eduardo Perez
Isoprenylcysteine (IPC) small molecules were discovered as signal transduction modulating compounds ~25 years ago. More recently, IPC molecules have demonstrated antioxidant and anti-inflammatory properties in a variety of dermal cells as well as antimicrobial activity, representing a novel class of compounds to ameliorate skin conditions and disease. Here, we demonstrate a new IPC compound, N-acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191), which inhibits UVB-induced inflammation blocking pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) production...
December 17, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27965034/the-ins-and-outs-of-calcium-signalling-in-lactation-and-involution-implications-for-breast-cancer-treatment
#18
Felicity M Davis
The mammary epithelium is highly responsive to hormonal and non-hormonal signalling cues for physiological growth, function and tissue remodelling. Whilst steroid hormones freely diffuse across the cell membrane to bind to intracellular hormone receptors, cell-impermeable ligands, including many peptide hormones, growth factors and cytokines, bind to receptors on the plasma membrane and relay their message via the specific activation of intracellular signal transduction pathways. A signalling pathway that is indispensable for decoding many extracellular signals into cellular responses is calcium (Ca(2+))...
December 10, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27960151/il-35-inhibits-angiogenesis-through-vegf-ang2-tie2-pathway-in-rheumatoid-arthritis
#19
Shenyi Jiang, Yuxuan Li, Tiantian Lin, Lin Yuan, Yunxia Li, Suqin Wu, Liping Xia, Hui Shen, Jing Lu
BACKGROUND/AIMS: The pro-angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietins (Angs) play a prominent role in synovial angiogenesis, an early and critical event in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-35 is an anti-inflammatory cytokine that attenuates collagen-induced arthritis, however, the mechanisms involved are not fully understood. METHODS: The effects of IL-35 on endothelial cell migration, adhesion, and tube formation were examined using human umbilical vein endothelial cells (HUVEC) in vitro...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27956526/tlr10-is-a-b-cell-intrinsic-suppressor-of-adaptive-immune-responses
#20
Nicholas J Hess, Song Jiang, Xinyan Li, Yue Guan, Richard I Tapping
Toll-like receptors play a central role in the initiation of adaptive immune responses with several TLR agonists acting as known B cell mitogens. Despite thousands of publications on TLRs, the function of TLR10 remains unknown. We have found that Ab-mediated engagement of TLR10 on primary human B cells suppresses B cell proliferation, cytokine production, and signal transduction. When challenged with either a T independent or T dependent Ag, TLR10 transgenic mice exhibit diminished Ab responses. Adoptive transfer of splenic B cells into B cell-deficient mice revealed that the suppressive effects on Ag-specific humoral immune responses are entirely B cell intrinsic...
January 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
keyword
keyword
32587
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"