Xia Yang, Qiaorui Bai, Weizhong Chen, Jiaer Liang, Fang Wang, Weiqi Gu, Lei Liu, Quanfeng Li, Zishuo Chen, Anni Zhou, Jianting Long, Han Tian, Jueheng Wu, Xiaofan Ding, Ningning Zhou, Mengfeng Li, Yi Yang, Junchao Cai
The importance of mRNA N6-methyladenosine (m6 A) modification during tumor metastasis is controversial as it plays distinct roles in different biological contexts. Moreover, how cancer cell plasticity is shaped by m6 A modification is interesting but remains uncharacterized. Here, this work shows that m6 A reader insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) is remarkably upregulated in metastatic lung adenocarcinoma (LUAD) and indicates worse prognosis of patients. Interestingly, IGF2BP3 induces partial epithelial-mesenchymal-transition (EMT) and confers LUAD cells plasticity to metastasize through m6 A-dependent overactivation of Notch signaling...
May 12, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)